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isoflurane donor

Chris Nevitt, Grant McKenzie, Katelyn Christian, Jeff Austin, Sarah Hencke, James Hoying, Amanda LeBlanc
Aging and cardiovascular disease are associated with the loss of nitric oxide (NO) signaling and a decline in the ability to increase coronary blood flow reserve (CFR). Thrombospondin-1 (Thbs-1), through binding of CD47, has been shown to limit NO-dependent vasodilation in peripheral vascular beds via formation of superoxide (O2 (-)). The present study tests the hypothesis that, similar to the peripheral vasculature, blocking CD47 will improve NO-mediated vasoreactivity in coronary arterioles from aged individuals, resulting in improved CFR...
June 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Krzysztof Szyfter, Ireneusz Stachecki, Magdalena Kostrzewska-Poczekaj, Marcin Szaumkessel, Joanna Szyfter-Harris, Paweł Sobczyński
Volatile anaesthetics such as halothane, isoflurane and others were expected to produce a health challenge for operation room personnel because of prolonged occupational exposure to anaesthetic gases. To estimate a molecular background of adverse health effects, a cohort of 100 exposed individuals was studied by the single-cell gene electrophoresis (comet assay) test. DNA lesions in lymphocytes of the exposed group did not differ significantly compared with non-exposed blood donors. Then, the exposed group was further divided according to job position...
August 2016: Journal of Applied Genetics
C Li, F Qi, T Liu, H Wang, P-Z Wang
BACKGROUND: The small animal model of cardiac transplantation is the most common model in organ transplantation studies. The cervical heterotopic transplantation is widely performed because this allows for direct observation of the graft heartbeat and contributes to early prediction of graft rejection. OBJECTIVE: A mouse-rat cervical heterotopic cardiac xenotransplantation model was modified with respect to the anesthesia method, cardiac graft harvesting method, and perioperative treatment...
July 2015: Transplantation Proceedings
M Ucar, U Ozgül, A Polat, H I Toprak, M A Erdogan, M S Aydogan, M Durmus, M O Ersoy
BACKGROUND: The safety of healthy volunteer donors is one of the most important issues in living-donor liver transplantation. Use of the Pringle maneuver during donor hepatectomy can result in liver ischemia-reperfusion (IR) injury. The objective of this study was to examine the effects of isoflurane and propofol on IR injury caused by the Pringle maneuver during donor hepatectomy. METHODS: A total of 70 American Society of Anesthesiology I-II donors aged 18-65 years who underwent hepatectomy were included in the study...
March 2015: Transplantation Proceedings
Tatjana I Kichko, Florian Niedermirtl, Andreas Leffler, Peter W Reeh
BACKGROUND: Irritating effects of volatile general anesthetics on tracheal nerve endings and resulting spastic reflexes in the airways are not completely understood with respect to molecular mechanisms. Neuropeptide release and neurogenic inflammation play an established role. METHODS: The basal and stimulated calcitonin gene-related peptide (CGRP) release from the isolated superfused mouse trachea was analyzed as an index of sensory neuron activation, applying irritant (desflurane and isoflurane) and nonirritant (sevoflurane) volatile anesthetics as stimuli...
February 2015: Anesthesia and Analgesia
Siluê Z F Dal Molin, Cleber R P Kruel, Raquel S de Fraga, Carolina Alboim, Jarbas R de Oliveira, Mario R Alvares-da-Silva
BACKGROUND: The mechanisms involved in organ protection by volatile anaesthetics are not completely understood. In the liver transplant setting, there is a lack of information in the literature about whether sevoflurane anaesthesia has a superior hepatoprotective effect when compared with isoflurane. OBJECTIVE: To compare the antioxidant and protective effects of isoflurane and sevoflurane. DESIGN: A randomised, comparative, experimental study...
December 2014: European Journal of Anaesthesiology
Dipankar Sutradhar, Therese Zeegers-Huyskens, Asit K Chandra
The conformation and the interaction of CHF₂OCF₂CHF₂ (desflurane II) with one water molecule is investigated theoretically using the ab initio MP2/aug-cc-pvdz and DFT-based M062X/6-311++G(d,p) methods. The calculations include the optimized geometries, the harmonic frequencies of relevant vibrational modes along with a natural bond orbital (NBO) analysis including the NBO charges, the hybridization of the C atom and the intra- and intermolecular hyperconjugation energies. In the two most stable conformers, the CH bond of the F2HCO- group occupies the gauche position...
November 2013: Journal of Molecular Modeling
W H Kim, H S Joo, J S Ko, M S Gwak, S K Lee, G S Kim
INTRODUCTION: The requirements of nondepolarizing neuromuscular blocking agent during liver transplantation show conflicting results. We sought to evaluate the requirements according to the operative phase and find extrahepatic factors that influence neuromuscular blocking agent requirements. METHODS: We enrolled 35 patients undergoing living donor liver transplantation. Continuous infusion of vecuronium was adjusted every 15 minutes for consistent neuromuscular blockade aimed at T1/Tc of 0...
June 2013: Transplantation Proceedings
U Ozgul, M Ucar, M A Erdogan, M S Aydogan, H I Toprak, C Colak, M Durmus, M O Ersoy
We compared postoperative hepatic and renal functions and coagulation profiles in living donors undergoing right hepatectomy under isoflurane (n = 40) versus propofol (n = 40) anesthesia. After induction, anesthesia was maintained with isoflurane/air-O2 (group I) or propofol/air-O2 (group P) in addition to remifentanil and atracurium infusion in both groups. Aspartate aminotransferase, alanine aminotransferase, international normalized ratio (INR), activated partial thromboplastin time (aPTT), albumin, total bilirubin, blood urea nitrogen, creatinine, estimated glomerular filtration rate (GFR), platelet count, and hemoglobin levels were measured in the preoperative period, after end of the operation, and on the first, third, fifth and seventh postoperative days (PODs)...
April 2013: Transplantation Proceedings
J H Lee, D J Joo, J M Kim, J H Park, Y S Kim, B N Koo
BACKGROUND: In living donor kidney transplantation (LDKT), we evaluated if there was any difference in grafted kidney function according to the type of anesthetic used in the donor because some laboratory studies have demonstrated that volatile anesthetics at clinically relevant concentrations protect the kidneys against renal ischemia-reperfusion injury. METHODS: In part I of the study, we retrospectively compared grafted kidney function [serum creatinine levels (Cr) and estimated glomerular filtration rates (eGFR) in recipients of LDKT] according to the type of donors' volatile anesthetic (sevoflurane [group Sevo, 166 patients], isoflurane [group Iso, 55] or desflurane [group Des, 61])...
May 2013: Minerva Anestesiologica
Hsin-I Tsai, An-Hsun Chou, Ming-Wen Yang
OBJECTIVE: Transfusion-related acute lung injury (TRALI) is the leading morbidity and mortality in hemotherapy in the United States. Although it is a serious complication of blood transfusion, it is still underestimated and under-reported because of under-recognition and misdiagnosis. In this report, we present 15 surgical patients who developed pulmonary complications secondary to blood transfusion during the perioperative period. METHODS: A 3-year retrospective analysis of 14,441 patients who received blood transfusion intraoperatively in our Taoyuan center was carried out...
September 2012: Acta Anaesthesiologica Taiwanica: Official Journal of the Taiwan Society of Anesthesiologists
H I Toprak, T Şahin, S Aslan, K Karahan, M Şanli, M Ö Ersoy
We compared the effect of two inhalation anesthetics desflurane and isoflurane on postoperative hepatic and renal functions as well as coagulation profiles in living donors undergoing right hepatectomy. This study was performed on 80 patients who were randomly allocated to group D (desflurane, n = 40) or group I (isoflurane, n = 40) after Faculty Ethics Committee approval. After induction, isoflurane or desflurane was used with air/oxygen for anesthetic maintenance. The isoflurane or desflurane concentration was set at one minimum alveolar concentration (MAC)...
July 2012: Transplantation Proceedings
Scott G Canfield, Ana Sepac, Filip Sedlic, Maria Y Muravyeva, Xiaowen Bai, Zeljko J Bosnjak
INTRODUCTION: Anesthetic preconditioning protects cardiomyocytes from oxidative stress-induced injury, but it is ineffective in patients with diabetes mellitus. To address the role of hyperglycemia in the inability of diabetic individuals to be preconditioned, we used human cardiomyocytes differentiated from induced pluripotent stem cells generated from patients with or without type 2 diabetes mellitus (DM-iPSC- and N-iPSC-CMs, respectively) to investigate the efficacy of preconditioning in varying glucose conditions (5, 11, and 25 mM)...
October 2012: Anesthesiology
Bernhard Floerchinger, Xiaodong Yuan, Anke Jurisch, Marc-Olivier Timsit, Xupeng Ge, Ying-Lung Lee, Christof Schmid, Stefan G Tullius
BACKGROUND: Brain death impairs donor organ quality and accelerates immune responses after transplantation. Detailed aspects of immune activation following brain death remain unclear. We have established a mouse model and investigated the immediate consequences of brain death and anesthesia on immune responses. METHODS: C57JBl/6 mice (n=6/group) were anesthetized with isoflurane (ISF) or ketamine/xylazine (KX); subsequently, animals underwent brain death induction and were followed for 3h under continuous ventilation...
August 2012: Transplant Immunology
J S Ko, G Kim, Y H Shin, M S Gwak, G S Kim, C H D Kwon, J W Joh
PURPOSE: Considering the severe nature of living donor right hepatectomy (removal of two thirds of the original liver), identification of an anesthetic agent having a minimal impact on postoperative organ function seems important. We compared postoperative hepatic and renal functions between 2 inhalational anesthetics, desflurane (Des) and isoflurane (Iso) among living donors undergoing right hepatectomy. METHOD: Sixty-four adult donors included in this retrospective study were divided into a Des group (n=32) and an Iso group (n=32)...
March 2012: Transplantation Proceedings
Wengang Ding, Zhitao Li, Xiaoxu Shen, Jackie Martin, S Bruce King, Vidhya Sivakumaran, Nazareno Paolocci, Wei Dong Gao
Isoflurane (ISO) is known to depress cardiac contraction. Here, we hypothesized that decreasing myofilament Ca(2+) responsiveness is central to ISO-induced reduction in cardiac force development. Moreover, we also tested whether the nitroxyl (HNO) donor 1-nitrosocyclohexyl acetate (NCA), acting as a myofilament Ca(2+) sensitizer, restores force in the presence of ISO. Trabeculae from the right ventricles of LBN/F1 rats were superfused with Krebs-Henseleit solution at room temperature, and force and intracellular Ca(2+) ([Ca(2+)](i)) were measured...
December 2011: Journal of Pharmacology and Experimental Therapeutics
Alberto Lesarri, Alicia Vega-Toribio, Richard D Suenram, Dale J Brugh, Davood Nori-Shargh, James E Boggs, Jens-Uwe Grabow
The conformational and structural properties of the inhalational anesthetic isoflurane (1-chloro-2,2,2-trifluoroethyl difluoromethyl ether) have been probed in a supersonic jet expansion using Fourier-transform microwave (FT-MW) spectroscopy. Two conformers of the isolated molecule were identified from the rotational spectrum of the parent and several (37)Cl and (13)C isotopologues detected in natural abundance. The two most stable structures of isoflurane are characterized by an anti carbon skeleton (τ(C(1)-C(2)-O-C(3)) = 137...
April 14, 2011: Physical Chemistry Chemical Physics: PCCP
A Ruzza, R Vespignani, L S Czer, M De Robertis, G N Wu, A Trento
OBJECTIVE: An updated anesthetic and surgical technique in a rat model of heterotopic heart transplantation is described. MATERIALS AND METHODS: A microsurgical technique via a suprarenal approach was performed, and is described in stepwise fashion, and several technical improvements are compared with previous descriptions. Lewis rats were used as donors and recipients (syngeneic model). RESULTS: Factors that affected early surgical outcome included type of anesthetic used; surgeon skill, experience in handling blood vessels, and knowledge of small-animal anatomy; gentle manipulation during the operation; and duration of surgery (<1 hour)...
November 2010: Transplantation Proceedings
Anne Dieterle, Michael J M Fischer, Andrea S Link, Winfried L Neuhuber, Karl Messlinger
BACKGROUND: Nitrovasodilators, such as glyceroltrinitrate (GTN), which produce nitric oxide (NO) in the organism, are known to cause delayed headaches in migraineurs, accompanied by increased plasma levels of calcitonin gene-related peptide (CGRP) in the cranial venous outflow. Increases in plasma CGRP and NO metabolites have also been found in spontaneous migraine attacks. In a rat model of meningeal nociception, infusion of NO donors induced activity of neurons in the spinal trigeminal nucleus...
January 2011: Cephalalgia: An International Journal of Headache
Y K Kim, W J Shin, J G Song, I G Jun, H Y Kim, S H Seong, B H Sang, G S Hwang
BACKGROUND: Hepatic resection may be associated with postoperative coagulopathy. However, there is limited information about the predictors affecting coagulopathy after donor hepatectomy. We evaluated the contributors of maximal changes in prothrombin time (PT), activated thromboplastin time (aPTT), and platelet count in the development of postoperative coagulopathy. METHODS: We retrospectively analyzed 864 living donors, all of whom received general anesthesia using desflurane, isoflurane, or sevoflurane...
September 2010: Transplantation Proceedings
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