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https://www.readbyqxmd.com/read/29341922/sustained-release-timolol-maleate-loaded-ocusert-based-on-biopolymer-composite
#1
Revathy V Nair, Shefrin S, Akhil Suresh, Anoop K R, Sreeja C Nair
In the present investigation, the effect of timolol maleate loaded ocuserts was studied as an alternative for conventional anti-glaucoma formulation. Ocuserts were prepared using natural polymer sodium alginate and ethyl cellulose. Physico-chemical properties along with drug entrapment efficiency (94-98%), content uniformity (93.1% ± 0.264-98.00% ± 0.321), in vitro drug release (83.42% ± 0.35 at end of 12 hours), ex vivo permeation all showed satisfactory results, which was found to follow zero order kinetics...
January 13, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29336690/advanced-glaucoma-at-presentation-is-associated-with-poor-follow-up-among-glaucoma-patients-attending-a-tertiary-eye-facility-in-southern-nigeria
#2
Rita Omoso Momoh, Catey Bunce, Gregrey Agbonvihele Oko-Oboh, Clare E Gilbert
PURPOSE: Globally, particularly in Africa, poor compliance with medication is a major problem in glaucoma management but little is known about follow-up rates among African glaucoma patients. The aim of this study was to determine rates of follow-up among glaucoma patients attending a tertiary hospital in southern Nigeria and investigate predictors of poor follow-up. METHODS: Data were extracted from medical records of new glaucoma patients who attended the hospital between June 2011 and May 2013...
January 16, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29288733/ophthalmic-gels-past-present-and-future
#3
Ali A Al-Kinani, Ghada Zidan, Naba Elsaid, Ali Seyfoddin, Adam W G Alani, Raid G Alany
Aqueous gels formulated using hydrophilic polymers (hydrogels) along with those based on stimuli responsive polymers (in situ gelling or gel forming systems) continue to attract increasing interest for various eye health-related applications. They allow the incorporation of a variety of ophthalmic pharmaceuticals to achieve sustained and therapeutic levels of drugs and bioactives at target ocular sites. The integration of sophisticated drug delivery technologies such as nanotechnology-based, intelligent and environment responsive systems can extend current treatment duration to provide more clinically relevant time courses (weeks and months instead of hours and days) which will inevitably reduce dose frequency, increase patient compliance and improve clinical outcomes...
December 27, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29197157/application-of-the-isnt-rules-on-retinal-nerve-fibre-layer-thickness-and-neuroretinal-rim-area-in-healthy-myopic-eyes
#4
Kunliang Qiu, Geng Wang, Xuehui Lu, Riping Zhang, Lixia Sun, Mingzhi Zhang
PURPOSE: We determined the applicability of inferior > superior > nasal > temporal (ISNT) rules on retinal nerve fibre layer (RNFL) thickness and rim area and evaluated the impact of various ocular factors on the performance of the ISNT rules in healthy myopic eyes. METHODS: A total of 138 eyes from 138 healthy myopic subjects were included in this cross-sectional observational study. The peripapillary RNFL and optic disc in each eye were imaged with Cirrus HD optical coherence tomography (OCT) and Heidelberg Retina Tomograph II (HRT2), respectively...
December 2, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29127001/long-term-intraocular-pressure-reduction-with-intracameral-polycaprolactone-glaucoma-devices-that-deliver-a-novel-anti-glaucoma-agent
#5
Jean Kim, Max Kudisch, Nina Rosa Konichi da Silva, Hiroyuki Asada, Eri Aya-Shibuya, Michele M Bloomer, Sri Mudumba, Robert B Bhisitkul, Tejal A Desai
Long-term treatment of glaucoma, a major leading cause of blindness, is challenging due to poor patient compliance. Therefore, a drug delivery device that can achieve drug release over several months can be highly beneficial for glaucoma management. Here, we evaluate the long-term pharmacokinetics and therapeutic efficacy of polycaprolactone intracameral drug delivery devices in rabbit eyes. Our study showed that a single drug delivery device loaded with a proprietary hypotensive agent, DE-117, reduced intraocular pressure in normotensive rabbits significantly for 23weeks...
November 7, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29022951/safety-of-fixed-drug-combination-in-post-operative-cataract-patients-at-tertiary-care-centre-in-south-india
#6
M Vidyadevi, A Anuradha, G Rashmi, R Shilpa, S Nishath
INTRODUCTION: Cataract is any opacification in lens or its capsule, which accounts for about 50% of treatable blindness worldwide. The prevalence of cataract in India is about 62.6%. The incidence of post operative endophthalmitis ranges from 0.05% - 0.14% and so the use of post-operative antibiotics and steroids is necessary to control infection and prevent inflammation. Fixed drug combinations not only cut the cost but also the dosage and improve the compliance of patients in the immediate post operative period...
January 2017: Nepalese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28928631/glaucoma-biological-trabecular-and-neuroretinal-pathology-with-perspectives-of-therapy-innovation-and-preventive-diagnosis
#7
REVIEW
Raffaele Nuzzi, Federico Tridico
Glaucoma is a common degenerative disease affecting retinal ganglion cells (RGC) and optic nerve axons, with progressive and chronic course. It is one of the most important reasons of social blindness in industrialized countries. Glaucoma can lead to the development of irreversible visual field loss, if not treated. Diagnosis may be difficult due to lack of symptoms in early stages of disease. In many cases, when patients arrive at clinical evaluation, a severe neuronal damage may have already occurred. In recent years, newer perspective in glaucoma treatment have emerged...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28782783/poly-%C3%AE%C2%B5-caprolactone-nanocapsule-carriers-with-sustained-drug-release-single-dose-for-long-term-glaucoma-treatment
#8
Chih-Hung Lee, Yu-Jia Li, Chih-Ching Huang, Jui-Yang Lai
Glaucoma is an eye-related disease accompanied by highly elevated intraocular pressure (IOP), which causes damage to the optic nerve and results in vision loss and even blindness. Although the treatment of glaucoma with eye drops may reduce the IOP, eye drops have some limitations, such as poor patient compliance and short duration. To develop drug carriers that facilitate the sustained and long-term release of drugs for glaucoma therapy, we synthesized poly(ε-caprolactone) nanoparticles (PCL NPs) capable of loading pilocarpine, a widely used drug for the treatment of dry eye and glaucoma...
August 17, 2017: Nanoscale
https://www.readbyqxmd.com/read/28764889/can-home-monitoring-allow-earlier-detection-of-rapid-visual-field-progression-in-glaucoma
#9
Andrew J Anderson, Phillip A Bedggood, Yu Xiang George Kong, Keith R Martin, Algis J Vingrys
PURPOSE: Recent developments in electronic technology are making it possible to home monitor the sensitivity of the central visual field using portable devices. We used simulations to investigate whether the higher test frequency afforded by home monitoring improves the early detection of rapid visual field loss in glaucoma and how any benefits might be affected by imperfect compliance or increased variability in the home-monitoring test. DESIGN: Computer simulation, with parameter selection confirmed with a cohort study...
July 29, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28617721/analysis-of-a-physician-led-team-based-care-model-for-the-treatment-of-glaucoma
#10
Nelson S Winkler, Gena M Damento, Sunil S Khanna, David O Hodge, Cheryl L Khanna
PURPOSE: To determine the effect of a protocol for a new physician-led, team-based glaucoma care model implemented in 2008 at Mayo Clinic's campus in Rochester, Minnesota (MCR), to increase conformance with the American Academy of Ophthalmology (AAO) Preferred Practice Pattern guidelines for treatment of primary open-angle glaucoma. METHODS: Records of 591 patients with newly diagnosed glaucoma were assessed retrospectively for the completion of 9 AAO Preferred Practice Pattern recommended metrics including measured corneal thickness, intraocular pressure (IOP), cup to disk ratio, visual acuity, recorded IOP target, gonioscopy, fundus photos, ocular coherence tomography, and visual field in the 3 years before and 3 years after protocol implementation...
August 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28584204/decision-making-impairments-in-primary-angle-closure-glaucoma-patients
#11
Hui Pu, Yong Wang, Qiang Wei, Hui-Juan Ma, Pan-Pan Hu, Shou-Ling Li, Hong-Bo Pang, Yang-Hua Tian, Kai Wang
BACKGROUND: Primary angle-closure glaucoma (PACG) is a common eye disease and a common cause of blindness. Inappropriate medical decisions severely affect the prognosis. This study investigated decision-making under risk in PACG patients. METHODS: Thirty patients with first acute attack of PACG before surgery and thirty healthy controls were included in the study. Decision-making under risk was evaluated with the game of dice task (GDT). The results of Eysenck Personality Questionnaire (EPQ) and GDT between PACG patients and healthy controls were compared...
June 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28571839/-perception-of-glaucoma-and-therapeutic-adherence-a-multicenter-observational-study
#12
A Chiche, G Martin, E Brasnu de Cenival, A Rousseau, A Giocanti, A Fel, S Kallel, M Lombardi, P Hamard, C Baudouin, A Labbe
INTRODUCTION: The purpose of this study was to evaluate medication adherence of glaucoma patients through the "Glaucoma treatment compliance assessment tool (GTCAT)" questionnaire and to correlate the results with clinical parameters. PATIENTS AND METHODS: This multicenter prospective observational study was performed in the Département hospitalo-universitaire (DHU) Sight Restore, Paris, France. All patients had been followed for chronic open angle glaucoma (COAG) for at least 3 years...
May 29, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28525561/decade-long-profile-of-imaging-biomarker-use-in-ophthalmic-clinical-trials
#13
REVIEW
Edoardo Villani, Domenico Massaro, Matteo Scaramuzzi, Pedram Hamrah, Felipe A Medeiros, Paolo Nucci
Purpose: The purpose of this study was to investigate the use of imaging biomarkers in published clinical trials (CTs) in ophthalmology and its eventual changes during the past 10 years. Methods: We sampled from published CTs in the fields of cornea, retina, and glaucoma between 2005-2006 and 2015-2016. Data collected included year of publication, phase, subspecialty, location, compliance with Consolidated Standards for Reporting Trials, impact factor, presence and use of imaging biomarkers (diagnostic, prognostic and predictive; primary and secondary surrogate endpoints), and use of centralized reading centers...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28404532/cost-effectiveness-and-cost-utility-of-community-screening-for-glaucoma-in-urban-india
#14
Denny John, Rajul Parikh
OBJECTIVES: Population-based screening for glaucoma has been demonstrated to be cost-effective if targeted at high-risk groups such as older adults and those with a family history of glaucoma, and through use of a technician for conducting initial assessment rather than a medical specialist. This study attempts to investigate the cost-effectiveness of a hypothetical community screening and subsequent treatment programme for glaucoma in comparison with current practice (i.e. with no screening programme but with some opportunistic case finding) in the urban areas of India...
July 2017: Public Health
https://www.readbyqxmd.com/read/28356898/novel-pharmacologic-candidates-for-treatment-of-primary-open-angle-glaucoma
#15
REVIEW
Louise J Lu, James C Tsai, Ji Liu
Primary open-angle glaucoma (OAG) affects approximately 45 million people worldwide and more than 2.5 million people aged 40 years or older in the United States. Pharmacologic treatment for glaucoma is directed towards lowering intraocular pressure (IOP) to slow disease progression and delay visual field loss. Current medical treatment options for the lowering of IOP include the following classes of topical medications: beta-adrenergic antagonists, alpha-adrenergic agonists, cholinergic agonists, carbonic anhydrase inhibitors, and prostaglandin analogs...
March 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28302155/a-prospective-randomised-placebo-controlled-double-masked-three-armed-multicentre-phase-ii-iii-trial-for-the-study-of-a-topical-treatment-of-ischaemic-central-retinal-vein-occlusion-to-prevent-neovascular-glaucoma-the-strong-study-study-protocol-for-a-randomised
#16
Katrin Lorenz, Yvonne Scheller, Katharina Bell, Franz Grus, Katharina A Ponto, Felix Bock, Claus Cursiefen, Jens Flach, Marta Gehring, Tunde Peto, Rufino Silva, Yossi Tal, Norbert Pfeiffer
BACKGROUND: Neovascular glaucoma (NVG) is rare, comprising only 3.9% of all glaucoma cases. The most common cause of NVG is ischaemic central retinal vein occlusion (iCRVO). NVG frequently results in blindness and painful end-stage glaucomatous damage leading to the need for enucleation. Currently, there is no preventive therapy for NVG following iCRVO. Rescue treatments have severe drawbacks. Accordingly, there is a great need for preventing the often visually devastating outcomes of NVG...
March 16, 2017: Trials
https://www.readbyqxmd.com/read/28260356/-focus-on-popular-science-education-of-glaucoma-and-reduce-glaucomatous-low-vision-and-blindness
#17
X H Sun
The prevention of blindness caused by glaucoma is a difficult task. In order to accomplish the task better, we need the participation of whole society and popularize relevant medical knowledge. Popular science and related knowledge of glaucoma are needed to the people especially for high risk population. If people know glaucoma better and actively join the screening of glaucoma, we can find and diagnose glaucoma earlier, avoid late treatment and reduce the glaucomatous visual function impairment. For patients who had been diagnosed with glaucoma, they should aware and accept new medical concept and technique through systemic popular science education...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251091/a-cross-sectional-study-on-compliance-with-topical-glaucoma-medication-and-its-associated-socioeconomic-burden-for-a-chinese-population
#18
Man-Hin Lui, Jason Chun Ho Lam, Yi Lee Kwong, Tak Siu Wong, Pak Long Cheung, Sherri Shun Yan Lai, Pak Lun Yuen, Wai Yiu Lam, Ho Yan Chan, Yiu Fai Wong, Jimmy Shiu Ming Lai, Kendrick Co Shih
AIM: To estimate the overall drug compliance for local Chinese glaucoma patients on long-term topical treatment. METHODS: This was a retrospective cross-sectional study. Fifty-seven primary glaucoma patients from the subspecialty clinic of a publicly-funded tertiary care hospital in Hong Kong completed a questionnaire on compliance with topical glaucoma medication, attitude towards glaucoma and therapy and vision related quality of life. Noncompliance was defined as reporting missing more than or equal to 10% of the prescribed topical glaucoma medication during the 2wk immediately prior to the consultation...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28181960/barriers-to-glaucoma-medication-compliance-among-veterans-dry-eye-symptoms-and-anxiety-disorders
#19
Jack Stringham, Noy Ashkenazy, Anat Galor, Sarah R Wellik
OBJECTIVE: To identify barriers to compliance of medical treatment for glaucoma among veterans. METHODS: Patients with glaucoma from the Miami Veterans Affairs Eye Clinic (n=74) filled out a 63-question survey regarding dry eye symptoms, concurrent systemic disease, and medications. The association between glaucoma medical compliance was defined as self-reported adherence to drop regimens greater than 75% of the time. RESULTS: Eighty percent of veterans (n=59) reported compliance with glaucoma therapy...
January 6, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/27994392/bottle-characteristics-of-topical-international-glaucoma-medications-versus-local-brands-in-saudi-arabia
#20
COMPARATIVE STUDY
Nasser Al-Jumaian, Rizwan Malik, Rajiv Khandekar, Abdullah Al-Humaidan, Rana Al-Madany, Reham Al-Qahtani, Ahmed Altowairqi, Abdulwahab Al-Theeb, Babar Zaman, Leyla Al-Djasim, E Randy Craven, Deepak P Edward
WHAT IS KNOWN AND OBJECTIVE: Physical bottle characteristics differ of brand name topical glaucoma medications and local generic equivalents. This study compares the bottle characteristics of international topical glaucoma brands versus local brands from the Kingdom of Saudi Arabia. METHODS: Data were collected on bottle drum volume, drop volume, bottle squeezability, bottle tip diameter, labels and instructions, cap color coding, and clarity of the drug label. Density-based calculations of drops in bottle volume were assessed using an analytic balance...
October 2016: Middle East African Journal of Ophthalmology
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