Valentin Maisons, Anna Duval, Laurent Mesnard, Marie Frimat, Fadi Fakhouri, Steven Grangé, Aude Servais, Claire Cartery, Laurent Fauchier, Paul Coppo, Dimitri Titeca-Beauport, Nicolas Fage, Yahsou Delmas, Anne-Hélène Quérard, Guillaume Seret, Mickaël Bobot, Moglie Le Quintrec, Simon Ville, Florent von Tokarski, Sophie Chauvet, Alain Wynckel, Manon Martins, Juliet Schurder, Christelle Barbet, Bénédicte Sautenet, Philippe Gatault, Sophie Caillard, Vincent Vuiblet, Jean-Michel Halimi
Thrombotic microangiopathies (TMA) are usually associated with hematological features (RH-TMA). The epidemiology of TMA limited to kidneys (RL-TMA) is unclear Therefore, patients with TMA and native kidney biopsies were identified during 2009-2022 in 20 French hospitals and results evaluated. RL-TMA was present in 341/757 (45%) patients and associated with lower creatinine levels (median 184 vs 346 μmol/L) than RH-TMA. RL-TMA resulted from virtually all identified causes, more frequently from anti-VEGF treatment and hematological malignancies, but less frequently from shigatoxin-associated hemolytic uremic syndrome (HUS), systemic sclerosis, gemcitabine and bacterial infection, and even less frequently when three or more causes/triggers were combined (RL-TMA: 5%; RH-TMA: 12%)...
February 29, 2024: Kidney International