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https://www.readbyqxmd.com/read/28930765/encouraging-reflexivity-in-a-residency-leadership-development-program-expanding-outside-the-competency-approach
#1
Justin T Clapp, Emily K B Gordon, Dimitry J Baranov, Beulah Trey, Felice Y Tilin, Lee A Fleisher
PROBLEM: While leadership development is increasingly a goal of academic medicine, it is typically framed as competency acquisition, which can limit its focus to a circumscribed set of social behaviors. This orientation may also reinforce the cultural characteristics of academic medicine that can make effective leadership difficult, rather than training leaders capable of examining and changing this culture. Expanding leadership development so it promotes social reflexivity presents a way to bolster some of the weaknesses of the competency paradigm...
September 14, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28930437/c-and-n-metalated-nitriles-the-relationship-between-structure-and-selectivity
#2
Xun Yang, Fraser F Fleming
Metalated nitriles are exceptional nucleophiles capable of forging highly hindered stereocenters in cases where enolates are unreactive. The excellent nucleophilicity emanates from the powerful inductive stabilization of adjacent negative charge by the nitrile, which has a miniscule steric demand. Inductive stabilization is the key to understanding the reactivity of metalated nitriles because this permits a continuum of structures that range from N-metalated ketenimines to nitrile anions. Solution and solid-state analyses reveal two different metal coordination sites, the formally anionic carbon and the nitrile nitrogen, with the site of metalation depending intimately on the solvent, counterion, temperature, and ligands...
September 20, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28930279/comparative-evaluation-of-oxidative-stress-modulating-and-dna-protective-activities-of-aqueous-and-methanolic-extracts-of-acacia-catechu
#3
Ashwini Patil, Manisha Modak
Background: Plant-derived bioactive compounds are becoming immensely important as potential drugs. Different solvents are being used for extraction of these phytochemicals. Evaluation of biological activities of aqueous plant extracts is important as water soluble compounds would be more beneficial with respect to certification, safety and commercial issues. Oxidative stress is involved in development of many diseases; therefore, antioxidants are now being looked upon as convincing therapeutics against such diseases...
September 5, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930267/%C3%AE-selinene-rich-essential-oils-from-the-parts-of-callicarpa-macrophylla-and-their-antioxidant-and-pharmacological-activities
#4
Mahesh Chandra, Om Prakash, Ravendra Kumar, Rakesh Kumar Bachheti, Brij Bhushan, Mahesh Kumar, Anil Kumar Pant
Background:Callicarpa macrophylla (Varbenaceae) is a medicinal shrub and is traditionally used in India, China, and South Asia. Methods: The plant material was collected from lower Himalayan region of Uttarakhand in India. The essential oils from three different aerial parts were analyzed by GC-MS. Antioxidant activity, phenolic assay, and various pharmacological activities were determined by using existing methods which are generally practiced widely. Results: Over 51, 53, and 40 compounds were identified in C...
July 10, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930246/medicinal-plants-used-for-neuropsychiatric-disorders-treatment-in-the-hauts-bassins-region-of-burkina-faso
#5
Prosper T Kinda, Patrice Zerbo, Samson Guenné, Moussa Compaoré, Alin Ciobica, Martin Kiendrebeogo
Background: In Burkina Faso, phytotherapy is the main medical alternative used by populations to manage various diseases that affect the nervous system. The aim of the present study was to report medicinal plants with psychoactive properties used to treat neuropsychiatric disorders in the Hauts Bassins region, in the western zone of Burkina Faso. Methods: Through an ethnobotanical survey using structured questionnaire, 53 traditional healers (TH) were interviewed about neuropsychiatric disorders, medicinal plants and medical practices used to treat them...
May 19, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930228/interaction-of-plant-extracts-with-central-nervous-system-receptors
#6
REVIEW
Kenneth Lundstrom, Huyen Thanh Pham, Long Doan Dinh
Background: Plant extracts have been used in traditional medicine for the treatment of various maladies including neurological diseases. Several central nervous system receptors have been demonstrated to interact with plant extracts and components affecting the pharmacology and thereby potentially playing a role in human disease and treatment. For instance, extracts from Hypericum perforatum (St. John's wort) targeted several CNS receptors. Similarly, extracts from Piper nigrum, Stephania cambodica, and Styphnolobium japonicum exerted inhibition of agonist-induced activity of the human neurokinin-1 receptor...
February 23, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930222/add-on-complementary-medicine-in-cancer-care-evidence-in-literature-and-experiences-of-integration
#7
REVIEW
Elio Rossi, Mariella Di Stefano, Fabio Firenzuoli, Maria Valeria Monechi, Sonia Baccetti
Background: According to the literature an increasing number of cancer patients demand for complementary therapies during their disease. Research has demonstrated that some of these therapies are effective and safe as adjunctive treatments in specific symptoms of these patients. Methods: The aims of the paper are to review the main and recent papers of international literature on the effectiveness of complementary medicine (CM) therapies on side effects of anti-cancer protocols and improvement in the quality of life of oncological patients, and to describe the integration of evidence-based acupuncture, herbal medicine and homeopathy treatments in Public Cancer Network of the region of Tuscany...
January 24, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28930168/a-review-of-the-composition-of-the-essential-oils-and-biological-activities-of-angelica-species
#8
REVIEW
Kandasamy Sowndhararajan, Ponnuvel Deepa, Minju Kim, Se Jin Park, Songmun Kim
A number of Angelica species have been used in traditional systems of medicine to treat many ailments. Especially, essential oils (EOs) from the Angelica species have been used for the treatment of various health problems, including malaria, gynecological diseases, fever, anemia, and arthritis. EOs are complex mixtures of low molecular weight compounds, especially terpenoids and their oxygenated compounds. These components deliver specific fragrance and biological properties to essential oils. In this review, we summarized the chemical composition and biological activities of EOs from different species of Angelica...
September 20, 2017: Scientia Pharmaceutica
https://www.readbyqxmd.com/read/28929869/pharmacare-are-we-getting-the-right-medicines
#9
Gail Attara
Canada is the only country in the world with a national healthcare plan that does not include drug coverage. Coverage of necessary medications is a patchwork of inconsistent programs that does not always serve the very individuals it was created to help-those patients who need prescribed medicines. Our system needs radical, intuitive changes.
July 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929867/innovation-productivity-and-pricing-capturing-value-from-precision-medicine-technology-in-canada
#10
J C Herbert Emery, Jennifer D Zwicker
For new technology and innovation such as precision medicine to become part of the solution for the fiscal sustainability of Canadian Medicare, decision-makers need to change how services are priced rather than trying to restrain emerging technologies like precision medicine for short-term cost savings. If provincial public payers shift their thinking to be public purchasers, value considerations would direct reform of the reimbursement system to have prices that adjust with technologically driven productivity gains...
July 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28929865/false-positive-screens-and-lung-cancer-risk-in-the-national-lung-screening-trial-implications-for-shared-decision-making
#11
Paul F Pinsky, Christina R Bellinger, David P Miller
Objectives Low-dose computed tomography lung cancer screening has been shown to reduce lung cancer mortality but has a high false-positive rate. The precision medicine approach to low-dose computed tomography screening assesses subjects' benefits versus harms based on their personal lung cancer risk, where harms include false-positive screens and resultant invasive procedures. We assess the relationship between lung cancer risk and the rate of false-positive LDCT screens. Methods The National Lung Screening Trial randomized high-risk subjects to three annual screens with low-dose computed tomography or chest radiographs...
January 1, 2017: Journal of Medical Screening
https://www.readbyqxmd.com/read/28929696/-clinical-analysis-of-cervus-and-cucumis-polypeptide-injection-based-on-real-world-hospital-information-system
#12
Shuai-Ling Sun, Yan-Ming Xie, Yuan-Yuan Li, Yin Zhang, Dan-Hui Yi, Yan Zhuang
To analyze the clinical application of Cervus and Cucumis Polypeptide injection in the real world, in order to define the characteristics of clinical drug use and correlation, and provide reference for risk management and further study for Cervus and Cucumis Polypeptide injection. Descriptive analysis and association rules analysis were performed on 37 721 cases using Cervus and Cucumis Polypeptide injection in 26 hospitals nationwide. Cervus and Cucumis Polypeptide injection were mostly adopted by patients aged between 45 and 64(39...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929658/-study-on-uplc-fingerprint-of-red-ginseng-based-on-good-separation-and-good-purity-of-chromatographic-peaks
#13
Wei-Hong Feng, Chun Li, Li-Na Ji, Li-Xin Yang, Li-Xin Rong, Liang-Mian Chen, Hong Yi, Zhi-Min Wang
This study is to establish the UPLC fingerprint of red ginseng. The separation was performed on a Waters Acquity BEH C₁₈ column (2.1 mm × 50 mm,1.7 μm), with the mobile phase consisting of acetonitrile and water for gradient elution. The detection wavelength was set at 203 nm. The UPLC fingerprint of red ginseng was established by using sample chromatography of 22 different purchase areas and 26 common peaks were found. Compared with the reference substances, 11 of the common peaks were identified as ginsenosides Rg₁, ginsenoside Re, ginsenoside Rf, ginsenoside Rh₁, ginsenoside Rg₂, ginsenoside Rb₁, 20(S)-ginsenoside F₁, ginsenoside Rb₂, ginsenoside Rb3, 20(S)-ginsenoside Rg₃ and 20(R)-ginsenoside Rg₃, respectively...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929651/-evaluation-and-cumulative-characteristics-of-heavy-metals-in-soil-uncaria-rhynchophylla-system-of-different-functional-areas
#14
Jia-Chun Zhang, Xian-Ping Zeng, Zhen-Ming Zhang, Shao-Xia Lin, Qing-Hai Zhang, Chang-Hu Lin
Soil and Uncaria rhynchophylla in different functional areas were selected for the study,the content of heavy metals such as As, Cd, Cu, Cr, Pb, and Hg in soil and U. rhynchophylla was discussed, the characteristics of their accumulation in the U.rhynchophylla was analyzed, the contamination levels of heavy metals in soil in different functional areas was evaluated. The results showed that content of Cu, As, Pb and Cr in soil was being cropland>woodland>wasteland, content of Cd was being woodland>cropland>wasteland, content of Hg was being cropland>woodland>wasteland...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929644/-current-status-and-prospects-of-traditional-chinese-medicine-resource-ex-situ-conservation
#15
REVIEW
Ling Que, Guang Yang, Jian-Hua Miao, Hai-Yang Wang, Min Chen, Chun-Xin Zang
Protection of traditional Chinese medicine (TCM) resources is the foundation of sustainable development of TCM industry, which includes the in-situ and ex-situ conservation. The development of TCM resource ex-situ conservation was reviewed, and hotpots in the conservation and its development practices were analyzed. Therefore national TCM resource ex-situ conservation systems were proposed, including the establishment of TCM resources introduction gardens, TCM resource in vitro conservation library and TCM resource bio-information sharing platform, rational distribution of TCM resources ex-situ conservation agencies, along with the advancement of TCM varieties breeding, and the perfection of Chinese herbal medicines seed and seedlings market, which are of significant importance on the guidance of TCM resource ex-situ conservation development...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929445/physicians-questions-concerning-drug-use-among-older-patients-experience-from-norwegian-drug-information-centres-relis-in-the-period-2010-2015
#16
Jan Schjøtt
Questions from physicians to regional medicines information and pharmacovigilance centres in Norway (RELIS) concerning older patients were described. Question-answer pairs (QAPs) from the RELIS database indexed with the category "older", and concerning individual patients from the period 01 Jan 2010 to 31 Dec 2015, were analysed. Two-hundred and eight QAPs categorized with "older" were retrieved from a total of 16 710 in the study period, and 122 of 208 QAPs fulfilled the inclusion criteria. The most common categories of drugs in question (n = 228) according to the ATC system were N: Nervous system (30...
September 19, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28929408/yokukansan-reduces-cuprizone-induced-demyelination-in-the-corpus-callosum-through-anti-inflammatory-effects-on-microglia
#17
Taichi Nomura, Yoshio Bando, Hua You, Tatsuhide Tanaka, Shigetaka Yoshida
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS). The release of inflammatory cytokines and pro-oxidant molecules from microglia has been shown to play a key role in the pathology of MS. Thus, suppression of microglial cell activation is an attractive therapeutic option. Yokukansan, a traditional Japanese herbal medicine, has been shown to suppress microglial activity in the CNS. However, whether or not yokukansan reduces demyelination observed in the CNS during MS remains unknown...
September 19, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28929406/pharmacopollution-and-household-waste-medicine-hwm-how-reverse-logistics-is-environmentally-important-to-brazil
#18
André Luiz Pereira, Raphael Tobias de Vasconcelos Barros, Sandra Rosa Pereira
Pharmacopollution is a public health and environmental outcome of some active pharmaceutical ingredients (API) and endocrine-disrupting compounds (EDC) dispersed through water and/or soil. Its most important sources are the pharmaceutical industry, healthcare facilities (e.g., hospitals), livestock, aquaculture, and households (patients' excretion and littering). The last source is the focus of this article. Research questions are "What is the Household Waste Medicine (HWM) phenomenon?", "How HWM and pharmacopollution are related?", and "Why is a reverse logistic system necessary for HWM in Brazil?" This article followed the seven steps proposed by Rother (2007) for a systematic review based on the Cochrane Handbook and the National Health Service (NHS) Center for Reviews Dissemination (CDR) Report...
September 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28929207/-securpharm-e-%C3%A2-v-a%C3%A2-protective-shield-against-falsified-medicines
#19
REVIEW
Martin Bergen, Reinhard Hoferichter
It is the declared objective of the Falsified Medicines Directive 2011/62/EU to further improve the protection of patients from falsified pharmaceuticals. Therefore, it stipulates measures based on which falsified medicines in the supply chain can be more easily identified. This is the European legislature's reaction to an increase in falsified medicines. The EU Falsified Medicines Directive aims to create a uniform, standardized solution for protection from falsified drugs. From 9 February 2019 onward (according to the EU Regulation No...
September 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28929177/-falsified-pharmaceutical-products-legislative-measures-in-the-european-union-and-in-germany
#20
REVIEW
Burkhard Sträter
Falsified pharmaceutical products are multi-faceted and driven by great criminal power. The health risks for patients who are frequently very seriously ill are high. The problem in Europe has been recognised. The European Union has created statutory requirements that considerably improve and tighten the system of manufacturing, distribution and documentation, and of pharmaceutical product authorisations. The traceability of each package via safety features is strengthened and made binding by detailed delegated legislation...
September 19, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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