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Prostate brachytherapy

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https://www.readbyqxmd.com/read/28436359/robotic-prostatectomy-versus-brachytherapy-for-the-treatment-of-low-risk-prostate-cancer
#1
Claudio Giberti, Fabrizio Gallo, Maurizio Schenone, Emilio Gastaldi, Pierluigi Cortese, Gaetano Ninotta, Davide Becco
INTRODUCTION: To compare oncological and functional results of robot-assisted radical prostatectomy (RARP) and brachytherapy (BT) with a single-center prospective randomized study. MATERIALS AND METHODS: From January 2012 to January 2014, 165 patients with low risk prostate cancer, prostate volume ≤ 50 g, normal urinary (IPSS ≤ 7 and mean flow rate ≥ 15 mL/sec) and erectile functions (IIEF-5 > 17) were enrolled and randomly assigned to the RARP or BT group...
April 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28433432/ascende-rt-an-analysis-of-treatment-related-morbidity-for-a-randomized-trial-comparing-a-low-dose-rate-brachytherapy-boost-with-a-dose-escalated-external-beam-boost-for-high-and-intermediate-risk-prostate-cancer
#2
Sree Rodda, Scott Tyldesley, W James Morris, Mira Keyes, Ross Halperin, Howard Pai, Michael McKenzie, Graeme Duncan, Gerard Morton, Jeremy Hamm, Nevin Murray
PURPOSE: To report the genitourinary (GU) and gastrointestinal (GI) morbidity and erectile dysfunction in a randomized trial comparing 2 methods of dose escalation for high- and intermediate-risk prostate cancer. METHODS AND MATERIALS: ASCENDE-RT (Androgen Suppression Combined with Elective Nodal and Dose Escalated Radiation Therapy) enrolled 398 men, median age 68 years, who were then randomized to either a standard arm that included 12 months of androgen deprivation therapy and pelvic irradiation to 46 Gy followed by a dose-escalated external beam radiation therapy (DE-EBRT) boost to 78 Gy, or an experimental arm that substituted a low-dose-rate prostate brachytherapy (LDR-PB) boost...
January 6, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28425193/health-related-quality-of-life-outcomes-from-a-contemporary-prostate-cancer-registry-in-a-large-diverse-population
#3
Gary W Chien, Jeff M Slezak, Teresa N Harrison, Howard Jung, Joy S Gelfond, Chengyi Zhang, Edward Wu, Richard Contreras, Ronald K Loo, Steven J Jacobsen
OBJECTIVE: To assess the health-related quality of life (HRQoL) of patients with prostate cancer up to 24 months after treatment in a contemporary large diverse population. PATIENTS AND METHODS: Patients with newly diagnosed prostate cancer from March 2011 to January 2014 in our healthcare system were included. The Expanded Prostate Cancer Index Composite (EPIC-26) questionnaire was administered before treatment, and at 1, 3, 6, 12, 18, and 24 months after treatment up to November 2014 for all methods of treatment...
April 19, 2017: BJU International
https://www.readbyqxmd.com/read/28408533/brachytherapy-with-intratumoral-injections-of-radiometal-labeled-polymers-that-thermo-responsively-self-aggregate-in-tumor-tissues
#4
Kohei Sano, Yuko Kanada, Kengo Kanazaki, Ning Ding, Masahiro Ono, Hideo Saji
Brachytherapy is a type of radiotherapy wherein titanium capsules containing therapeutic radioisotopes are implanted within tumor tissues, enabling high-dose radio-irradiation to tumor tissues around the seeds. Although marked therapeutic effects have been demonstrated, brachytherapy needs complicated implantation technique under general anesthesia and the seeds could migrate to other organs. The aim of this study is to establish a novel brachytherapy using biocompatible, injectable thermo-responsive polymers (polyoxazoline; POZ) labeled with yttrium-90 ((90)Y), which can self-aggregate above a specific transition temperature, resulting in long-term intratumoral retention of radioactivity and therapeutic effect...
April 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28408078/adoption-of-radiation-technology-among-privately-insured-nonelderly-patients-with-cancer-in-the-united-states-2008-to-2014-a-claims-based-analysis
#5
Hubert Y Pan, Jing Jiang, Ya-Chen Tina Shih, Benjamin D Smith
Despite enthusiasm for advanced radiation technologies, understanding of their adoption in recent years is limited. The aim of this study was to elucidate utilization trends of conventional radiation, intensity-modulated radiotherapy (IMRT), brachytherapy, proton radiotherapy, stereotactic body radiotherapy (SBRT), and stereotactic radiosurgery (SRS) using a large convenience sample of irradiated patients with cancer identified from private insurance claims in the United States. The unit of analysis was a claim corresponding to a fraction of delivered radiotherapy from 2008 to 2014...
April 10, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28398296/trends-in-the-use-of-radiation-therapy-for-stage-iia-prostate-cancer-from-2004-to-2013-a-retrospective-analysis-using-the-national-cancer-database
#6
T Malouff, N W Mathy, S Marsh, R W Walters, P T Silberstein
BACKGROUND: Recent studies have shown a decrease in the overall use of radiation therapy in the treatment of prostate cancer over the past several decades, as well as a more conservative overall treatment approach. We aim to determine whether this trend continued from 2004 to 2013, and to determine whether there were changes in utilization for various types of radiation. METHODS: We conducted this retrospective study using the National Cancer Database. We identified 706 877 patients with sufficient treatment information diagnosed with stage IIA prostate cancer between 2004 and 2013...
April 11, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28396223/oncological-and-functional-results-of-robotic-salvage-radical-prostatectomy-after-permanent-brachytherapy-implants
#7
M Orré, T Piéchaud, P Sargos, P Richaud, G Roubaud, L Thomas
PURPOSE: To evaluate the feasibility of robotic salvage prostatectomy for local recurrence after permanent brachytherapy implants for prostate cancer. PATIENTS AND METHODS: Seven patients were operated by robotic salvage prostatectomy with or without pelvic lymph node dissection between October 2007 and March 2012, for a local recurrence after iodine 125 permanent brachytherapy implants. Local recurrence was proved by prostate biopsies, once biochemical relapse was diagnosed and imaging assessment performed...
April 7, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28396178/magnetic-resonance-imaging-basics-for-the-prostate-brachytherapist
#8
REVIEW
Jihong Wang, Kari Tanderup, Adam Cunha, Antonio L Damato, Gil'ad N Cohen, Rajat J Kudchadker, Firas Mourtada
Magnetic resonance imaging (MRI) is increasingly being used in radiation therapy, and integration of MRI into brachytherapy in particular is becoming more common. We present here a systematic review of the basic physics and technical aspects of incorporating MRI into prostate brachytherapy. Terminology and MRI system components are reviewed along with typical work flows in prostate high-dose-rate and low-dose-rate brachytherapy. In general, the brachytherapy workflow consists of five key components: diagnosis, implantation, treatment planning (scan + plan), implant verification, and delivery...
April 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28394521/-low-dose-rate-contact-radiation-therapy-brachytherapy-for-prostate-cancer-using-domestic-i-125-seeds-as-a-monotherapy-and-combined-with-pelvic-lymphadenectomy
#9
A D Kaprin, V N Galkin, S A Ivanov, O B Karyakin, V A Biryukov, A A Obukhov, V A Polyakov, A V Cher-Nichenko, A V Koryakin, N B Bryshev, O G Lepilina, A A Goverdovskiy
INTRODUCTION: In 2014, the incidence of prostate cancer in the Russian Federation was 116.4 per 100,000 population. It is noteworthy that from 2004 to 2014, the proportion of patients with stage I-II prostate cancer increased from 35.5% to 52.5%, while that of patients with stages III and IV disease decreased from 38.4% to 29% and from 22.7% to 16.5%, respectively. All of this allows an increasing number of prostate cancer patients to be treated with radical treatment - low dose-rate brachytherapy...
April 2017: Urologii︠a︡
https://www.readbyqxmd.com/read/28391989/towards-clinical-application-of-raystretch-for-heterogeneity-corrections-in-ldr-permanent-125-i-prostate-brachytherapy
#10
Fernando Hueso-González, Facundo Ballester, Jose Perez-Calatayud, Frank-André Siebert, Javier Vijande
PURPOSE: RayStretch is a simple algorithm proposed for heterogeneity corrections in low-dose-rate brachytherapy. It is built on top of TG-43 consensus data, and it has been validated with Monte Carlo (MC) simulations. In this study, we take a real clinical prostate implant with 71 (125)I seeds as reference and we apply RayStretch to analyze its performance in worst-case scenarios. METHODS AND MATERIALS: To do so, we design two cases where large calcifications are located in the prostate lobules...
April 5, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28381267/transperineal-template-guided-saturation-biopsy-aimed-at-sampling-one-core-for-each-milliliter-of-prostate-volume-103-cases-requiring-repeat-prostate-biopsy
#11
Yasushi Nakai, Nobumichi Tanaka, Satoshi Anai, Makito Miyake, Shunta Hori, Yoshihiro Tatsumi, Yosuke Morizawa, Tomomi Fujii, Noboru Konishi, Kiyohide Fujimoto
BACKGROUND: We evaluated the cancer detection rate of prostate cancer using transperineal template-guided saturation biopsy aimed at sampling one core for each milliliter of prostate volume for patients requiring repeated prostate biopsies. METHODS: In total, 103 consecutive patients with repeated prostate biopsies were enrolled in this retrospective study. The number of biopsy cores was defined by prostate volume. In principle, one biopsy core covered 1 mL of prostate volume...
April 5, 2017: BMC Urology
https://www.readbyqxmd.com/read/28377139/real-time-intraoperative-evaluation-of-implant-quality-and-dose-correction-during-prostate-brachytherapy-consistently-improves-target-coverage-using-a-novel-image-fusion-and-optimization-program
#12
Michael J Zelefsky, Gilad N Cohen, Amandeep S Taggar, Marisa Kollmeier, Sean McBride, Gig Mageras, Marco Zaider
PURPOSE: Our purpose was to describe the process and outcome of performing postimplantation dosimetric assessment and intraoperative dose correction during prostate brachytherapy using a novel image fusion-based treatment-planning program. METHODS AND MATERIALS: Twenty-six consecutive patients underwent intraoperative real-time corrections of their dose distributions at the end of their permanent seed interstitial procedures. After intraoperatively planned seeds were implanted and while the patient remained in the lithotomy position, a cone beam computed tomography scan was obtained to assess adequacy of the prescription dose coverage...
January 20, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28366276/high-dose-rate-brachytherapy-boost-for-prostate-cancer-analysis-of-dose-volume-histogram-parameters-for-predicting-late-rectal-toxicity
#13
Rodolfo Chicas-Sett, Dolores Farga, Maria J Perez-Calatayud, Francisco Celada, Susana Roldan, Victoria Fornes-Ferrer, Blanca Ibanez-Rosello, Alejandro Tormo, Jose M Benlloch, Jose Perez-Calatayud
PURPOSE: To determine the significance of dose-volume histogram parameters for predicting late rectal toxicity (LRT) after single-fraction high-dose-rate brachytherapy (HDRBT) boost and external beam radiotherapy (EBRT) in prostate cancer. MATERIALS AND METHODS: Three hundred patients with intermediate- or high-risk prostate cancer were included between August 2010 and March 2015. Treatment comprised a single-fraction HDRBT boost of 15.0 Gy plus EBRT (46.0 Gy delivered in 23 fractions) or an HDRBT boost of 9...
March 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28355119/high-intensity-focused-ultrasound-for-the-treatment-of-prostate-cancer-a-review
#14
Christian G Chaussy, Stefan Thüroff
Over the past 25 years, the average life expectancy for men has increased almost 4 years, and the age of prostate cancer detection has decreased an average of 10 years with diagnosis increasingly made at early-stage disease where curative therapy is possible. These changing trends in the age and extent of malignancy at diagnosis have revealed limitations in conventional curative therapies for prostate cancer, including a significant risk of aggressive cancer recurrence, and the risk of long-term genitourinary morbidity and its detrimental impact on patient's quality of life (QOL)...
April 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28350514/brachytherapy-for-patients-with-prostate-cancer-american-society-of-clinical-oncology-cancer-care-ontario-joint-guideline-update-summary
#15
Joseph Chin, R Bryan Rumble, D Andrew Loblaw
No abstract text is available yet for this article.
March 28, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28346805/brachytherapy-for-patients-with-prostate-cancer-american-society-of-clinical-oncology-cancer-care-ontario-joint-guideline-update
#16
Joseph Chin, R Bryan Rumble, Marisa Kollmeier, Elisabeth Heath, Jason Efstathiou, Tanya Dorff, Barry Berman, Andrew Feifer, Arthur Jacques, D Andrew Loblaw
Purpose To jointly update the Cancer Care Ontario guideline on brachytherapy for patients with prostate cancer to account for new evidence. Methods An Update Panel conducted a targeted systematic literature review and identified more recent randomized controlled trials comparing dose-escalated external beam radiation therapy (EBRT) with brachytherapy in men with prostate cancer. Results Five randomized controlled trials provided the evidence for this update. Recommendations For patients with low-risk prostate cancer who require or choose active treatment, low-dose rate brachytherapy (LDR) alone, EBRT alone, and/or radical prostatectomy (RP) should be offered to eligible patients...
March 27, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28344597/high-biologically-effective-dose-radiation-therapy-using-brachytherapy-in-combination-with-external-beam-radiotherapy-for-high-risk-prostate-cancer
#17
Keisei Okamoto, Akinori Wada, Naoaki Kohno
PURPOSE: To evaluate the outcomes of high-risk prostate cancer patients treated with biologically effective dose (BED) ≥ 220 Gy of high-dose radiotherapy, using low-dose-rate (LDR) brachytherapy in combination with external beam radiotherapy (EBRT) and short-term androgen deprivation therapy (ADT). MATERIAL AND METHODS: From 2005 to 2013, a total of 143 patients with high-risk prostate cancer were treated by radiotherapy of BED ≥ 220 Gy with a combination of LDR brachytherapy, EBRT, and androgen deprivation therapy (ADT)...
February 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28343795/use-of-mri-in-low-dose-rate-and-high-dose-rate-prostate-brachytherapy-from-diagnosis-to-treatment-assessment-defining-the-knowledge-gaps-technical-challenges-and-barriers-to-implementation
#18
S J Frank, F Mourtada, J Crook, C Ménard
MRI is rapidly evolving as an imaging tool in both low-dose-rate and high-dose-rate brachytherapy for prostate cancer. The ability of MRI to identify intraprostatic tumors and reduce uncertainties in the workflow process should enable a more accurate and precise radiation delivery approach while simultaneously improving the quality assurance process. The ability to identify functional anatomic structures adjacent to the prostate cancer could reduce or eliminate some of the more common side effects of the treatment...
March 23, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28341494/how-do-patients-choose-between-active-surveillance-radical-prostatectomy-and-radiotherapy-the-effect-of-a-preference-sensitive-decision-aid-on-treatment-decision-making-for-localized-prostate-cancer
#19
Romy E D Lamers, Maarten Cuypers, Marieke de Vries, Lonneke V van de Poll-Franse, J L H Ruud Bosch, Paul J M Kil
PURPOSE: To determine the effect of a decision aid (DA) on treatment preferences and to investigate which patient preferences are important for final treatment preferences. We also determined if the patient׳s treatment decision was influenced by the urologist׳s treatment preference. PATIENTS AND METHODS: Between August 2014 and July 2015, newly diagnosed patients with low-/intermediate-risk prostate cancer were offered to use a web-based DA after diagnosis. Treatment preferences and patient׳s values were extracted from the DA...
February 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28341241/high-dose-rate-brachytherapy-as-monotherapy-for-localised-prostate-cancer-review-of-the-current-status
#20
N Tselis, P Hoskin, D Baltas, V Strnad, N Zamboglou, C Rödel, G Chatzikonstantinou
The aim of this article is to review and present the published data on high dose rate (HDR) brachytherapy as monotherapy in the treatment of localised prostate cancer. A search and review of the literature was carried out on PubMed and MedLine using the medical subject headings 'high-dose-rate, brachytherapy, prostate cancer, monotherapy' as search terms. The search yielded more than 100 articles and abstracts published between 2000 and 2016. Only original clinical data on HDR monotherapy reporting oncological outcomes were included...
March 22, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
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