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Prostate brachytherapy

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https://www.readbyqxmd.com/read/28222069/patients-perceptions-of-the-negative-effects-following-different-prostate-cancer-treatments-and-the-impact-on-psychological-well-being-a-nationwide-survey
#1
Ulla-Sisko Lehto, Heli Tenhola, Kimmo Taari, Arpo Aromaa
BACKGROUND: Although the prognosis of localised prostate cancer is good, the negative effects of prostate cancer treatment often impair patient quality of life. A growing number of men experience these negative effects over a longer time because of the increased incidence of and prolonged survival in prostate cancer, and the ageing of the population. Only a few studies have investigated the adverse effects of different prostate cancer treatments using large population-based samples. METHODS: We conducted a nationwide survey (n=1239) to collect detailed information regarding the negative effects (i...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28209912/detection-efficacy-of-hybrid-68-ga-psma-ligand-pet-ct-in-prostate-cancer-patients-with-biochemical-recurrence-after-primary-radiation-therapy-defined-by-phoenix-criteria
#2
Ingo Einspieler, Isabel Rauscher, Charlotte Düwel, Markus Krönke, Christoph Rischpler, Gregor Habl, Sabrina Dewes, Armin Ott, Hans-Jürgen Wester, Markus Schwaiger, Tobias Maurer, Matthias Eiber
The aim of this retrospective study was to evaluate the detection rate of Glu-NH-CO-NH-Lys-(Ahx)-[(68)Ga(HBED-CC)] ((68)Ga-PSMA ligand) positron emission tomography/computed tomography (PET/CT) in patients with biochemical recurrent prostate cancer (PC) defined by Phoenix criteria after external beam radiotherapy (EBRT) or brachytherapy as primary treatment. Methods: 118 patients were finally eligible for this retrospective analysis with a median prostate-specific antigen (PSA) of 6.4 ng/mL (range: 2.2-158...
February 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28192614/cone-beam-ct-based-adaptive-planning-improves-permanent-prostate-brachytherapy-dosimetry-an-analysis-of-1266-patients
#3
Hendrik Westendorp, Carel J Hoekstra, Jos J Immerzeel, Sandrine M G van de Pol, Charles G H J Niël, Robert A J Kattevilder, Tonnis T Nuver, André W Minken, Marinus A Moerland
PURPOSE: To evaluate adaptive planning for permanent prostate brachytherapy and to identify the prostate regions that needed adaptation. METHODS AND MATERIALS: After the implantation of stranded seeds, using real-time intraoperative planning, a transrectal ultrasound (TRUS)-scan was obtained and contoured. The positions of seeds were determined on a C-arm cone-beam Computed Tomography (CBCT)-scan. The CBCT-scan was registered to the TRUS-scan using fiducial gold markers...
February 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/28190784/intraoperative-factors-associated-with-stranded-source-placement-accuracy-in-low-dose-rate-prostate-brachytherapy
#4
M F Jamaluddin, S Ghosh, M P Waine, M Tavakoli, J Amanie, A D Murtha, D Yee, N Usmani
PURPOSE: The quality of a low-dose rate prostate brachytherapy implant depends on the accurate placement of sources in their planned locations. This study investigates intraoperative factors that potentially contribute to stranded source placement inaccuracy in prostate brachytherapy. METHODS AND MATERIALS: Intraoperative video images of the brachytherapist's hand motions and needle insertions during the implant procedure were acquired for analysis. Using video analysis software, maximum and average needle insertion velocities were determined...
February 10, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28190638/long-term-toxicity-and-health-related-quality-of-life-after-single-fraction-high-dose-rate-brachytherapy-boost-and-hypofractionated-external-beam-radiotherapy-for-intermediate-risk-prostate-cancer
#5
N Shahid, A Loblaw, H T Chung, P Cheung, E Szumacher, C Danjoux, R Sankreacha, L Zhang, A Deabreu, A Mamedov, G Morton
AIMS: To report health-related quality of life (HRQOL) and toxicity in prostate cancer patients treated with single-fraction high dose rate (HDR) brachytherapy boost and external beam radiotherapy (EBRT). MATERIALS AND METHODS: Patients with intermediate-risk prostate cancer were accrued to a phase II clinical trial of 15 Gy HDR boost and EBRT to a dose of 37.5 Gy in 15 fractions. HRQOL (Expanded Prostate Cancer Index Composite [EPIC]), urinary symptoms (International Prostate Symptom Score [IPSS]), erectile function (International Index of Erectile Function [IIEF]) and toxicity (Common Terminology Criteria for Adverse Events [CTCAE], version 3...
February 9, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28187996/pattern-of-solid-and-hematopoietic-second-malignancy-after-local-therapy-for-prostate-cancer
#6
Chenyang Wang, Christopher R King, Mitchell Kamrava, Keisuke S Iwamoto, Allen M Chen, Daniel Low, Patrick A Kupelian, Michael L Steinberg
BACKGROUND AND PURPOSE: Second malignancies (SM) after external beam radiotherapy (EBRT) or brachytherapy (BT) for prostate cancer (PCa) are rare but serious sequelae. MATERIALS AND METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to identify men diagnosed with cT1-2N0M0 PCa between 1999 and 2005, who underwent EBRT, BT or radical prostatectomy (RP). Patients with time interval to second malignancy or follow-up shorter than five and two years were excluded for solid and hematopoietic SM analyses respectively...
February 7, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28187994/defining-the-value-of-magnetic-resonance-imaging-in-prostate-brachytherapy-using-time-driven-activity-based-costing
#7
Nikhil G Thaker, Peter F Orio, Louis Potters
Magnetic resonance imaging (MRI) simulation and planning for prostate brachytherapy (PBT) may deliver potential clinical benefits but at an unknown cost to the provider and healthcare system. Time-driven activity-based costing (TDABC) is an innovative bottom-up costing tool in healthcare that can be used to measure the actual consumption of resources required over the full cycle of care. TDABC analysis was conducted to compare patient-level costs for an MRI-based versus traditional PBT workflow. TDABC cost was only 1% higher for the MRI-based workflow, and utilization of MRI allowed for cost shifting from other imaging modalities, such as CT and ultrasound, to MRI during the PBT process...
February 7, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28187887/collapsed-cone-dose-calculations-for-heterogeneous-tissues-in-brachytherapy-using-primary-and-scatter-separation-source-data
#8
Anders Ahnesjö, Bob van Veelen, Åsa Carlsson Tedgren
BACKGROUND AND OBJECTIVE: Brachytherapy is a form of radiation therapy using sealed radiation sources inserted within or in the vicinity of the tumor of, e.g., gynecological, prostate or head- and neck cancers. Accurate dose calculation is a crucial part of the treatment planning. Several reviews have called for clinical software with model-based algorithms that better take into account the effects of patient individual distribution of tissues, source-channel and shielding attenuation than the commonly employed TG-43 formalism which simply map homogeneous water dose distributions onto the patient...
February 2017: Computer Methods and Programs in Biomedicine
https://www.readbyqxmd.com/read/28185419/accumulation-of-rectum-dose-volume-metrics-for-prostate-external-beam-radiotherapy-combined-with-brachytherapy-evaluating-deformably-registered-dose-distribution-addition-using-parameter-based-addition
#9
Calyn R Moulton, Michael J House, Victoria Lye, Colin I Tang, Michele Krawiec, David J Joseph, James W Denham, Martin A Ebert
INTRODUCTION: To investigate the accuracy of deriving dose-volume histogram (DVH) parameters from deformably registered data by comparing values with the simple addition of DVHs from each phase of a combined external beam radiotherapy (EBRT)/high-dose-rate (HDR-BT) brachytherapy prostate treatment. METHODS: Eighty-two patients received EBRT in 23 fractions of 2 Gy and HDR-BT TG43 in three fractions of 6.5 Gy. The HDR-BT CT was deformably registered to the EBRT CT...
February 9, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28168138/racial-disparity-in-prostate-cancer-specific-mortality-for-high-risk-prostate-cancer-a-population-based-study
#10
Chenyang Wang, Mitchell Kamrava, Chris King, Michael L Steinberg
INTRODUCTION: Race may be a significant factor that influences prostate cancer (PCa) survival, with the Asian (AsA) race being associated with better outcomes compared to African American (AA) and Non-Hispanic Whites (NHW). This study evaluates race-dependent variation in PCa-specific mortality (PCSM) associated with radiation dose-escalation exemplified by external beam radiotherapy (EBRT) with a brachytherapy (BT) boost in Gleason score 8-10 PCa. METHODS: 28,956 men diagnosed with clinically localized PCa and Gleason score 8-10 from 2004-2013 who received EBRT, EBRT with a BT boost, or radical prostatectomy (RP) were identified using the Surveillance, Epidemiology, and End Results (SEER) database...
January 6, 2017: Curēus
https://www.readbyqxmd.com/read/28161433/quantifying-125-i-placement-accuracy-in-prostate-brachytherapy-using-postimplant-transrectal-ultrasound-images
#11
Muhammad F Jamaluddin, Sunita Ghosh, Michael P Waine, Ronald S Sloboda, Mahdi Tavakoli, John Amanie, Albert D Murtha, Don Yee, Nawaid Usmani
PURPOSE: The quality of a prostate brachytherapy implant depends on the accurate placement of sources. This study quantifies the misplacement of (125)I sources from the intended location using intraoperative ultrasound images. METHODS AND MATERIALS: (125)I sources were manually identified in the postimplant ultrasound images and compared to the preoperative plan. Due to the subjective nature of the identifying sources, only sources identified with high confidence were included in the analysis...
February 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28161432/mri-in-prostate-brachytherapy-evidence-clinical-end-points-to-data-and-direction-forward
#12
Thomas J Pugh, Sajal S Pokharel
The integration of multiparametric MRI into prostate brachytherapy has become a subject of interest over the past 2 decades. MRI directed high-dose-rate and low-dose-rate prostate brachytherapy offers the potential to improve treatment accuracy and standardize postprocedure quality. This article reviews the evidence to date on MRI utilization in prostate brachytherapy and postulates future pathways for MRI integration.
February 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28160517/simultaneous-automatic-segmentation-of-multiple-needles-using-3d-ultrasound-for-high-dose-rate-prostate-brachytherapy
#13
William Thomas Hrinivich, Douglas A Hoover, Kathleen Surry, Chandima Edirisinghe, Jacques Montreuil, David D'Souza, Aaron Fenster, Eugene Wong
PURPOSE: Sagittally-reconstructed 3D (SR3D) ultrasound imaging shows promise for improved needle localization for high-dose-rate prostate brachytherapy (HDR-BT); however, needles must be manually segmented intra-operatively while the patient is anesthetized to create a treatment plan. The purpose of this article is to describe and validate an automatic needle segmentation algorithm designed for HDR-BT, specifically capable of simultaneously segmenting all needles in an HDR-BT implant using a single SR3D image with ~5 mm inter-needle spacing...
February 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28159553/brachytherapy-boost-for-prostate-cancer-trends-in-care-and-survival-outcomes
#14
S M Glaser, M J Dohopolski, G K Balasubramani, R M Benoit, R P Smith, S Beriwal
PURPOSE: Androgen suppression combined with elective nodal and dose-escalated radiation therapy recently demonstrated an improved biochemical failure-free survival in men who received external beam radiation therapy (EBRT) plus a brachytherapy boost (BB) compared with dose-escalated external beam radiotherapy (DE-EBRT). We sought to analyze the factors predictive for use of EBRT + BB as compared with DE-EBRT and report resulting survival outcomes on a national level using a hospital-based registry...
February 1, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28156003/population-based-validation-of-the-2014-isup-gleason-grade-groups-in-patients-treated-with-radical-prostatectomy-brachytherapy-external-beam-radiation-or-no-local-treatment
#15
Raisa S Pompe, Helen Davis-Bondarenko, Emanuele Zaffuto, Zhe Tian, Shahrokh F Shariat, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To test discriminant ability of the 2014 ISUP Gleason grade groups (GGG) for prediction of prostate cancer specific mortality (PCSM) after radical prostatectomy (RP), brachytherapy (BT), external beam radiation (EBRT) or no local treatment (NLT) relative to traditional Gleason grading (TGG). METHODS: In the Surveillance, Epidemiology, and End Results (SEER)-database (2004-2009), 2,42,531 non-metastatic prostate cancer (PCa) patients were identified, who underwent local treatment (RP, BT, EBRT only) or NLT...
February 3, 2017: Prostate
https://www.readbyqxmd.com/read/28153700/clinical-use-of-magnetic-resonance-imaging-across-the-prostate-brachytherapy-workflow
#16
P Blanchard, C Ménard, S J Frank
MRI produces better soft tissue contrast than does ultrasonography or computed tomography for visualizing male pelvic anatomy and prostate cancer. Better visualization of the tumor and organs at risk could allow better conformation of the dose to the target volumes while at the same time minimizing the dose to critical structures and the associated toxicity. Although the use of MRI for prostate brachytherapy would theoretically result in an improved therapeutic ratio, its implementation been slow, mostly because of technical challenges...
January 30, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28143764/prostate-specific-antigen-density-is-predictive-of-outcome-in-suboptimal-prostate-seed-brachytherapy
#17
David Benzaquen, Guila Delouya, Cynthia Ménard, Maroie Barkati, Daniel Taussky
PURPOSE: In prostate seed brachytherapy, a D90 of <130 Gy is an accepted predictive factor for biochemical failure (BF). We studied whether there is a subpopulation that does not need additional treatment after a suboptimal permanent seed brachytherapy implantation. METHODS AND MATERIALS: A total of 486 patients who had either BF or a minimum followup of 48 months without BF were identified. BF was defined according to the Phoenix definition (nadir prostate-specific antigen + 2)...
January 28, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28140369/modeling-the-impact-of-prostate-edema-on-ldr-brachytherapy-a-monte-carlo-dosimetry-study-based-on-a-3d-biphasic-finite-element-biomechanical-model
#18
K A Mountris, J Bert, J Noailly, A Rodriguez Aguilera, A Valeri, O Pradier, U Schick, E Promayon, M A Gonzalez Ballester, J Troccaz, D Visvikis
Prostate volume changes due to edema occurrence during transperineal permanent brachytherapy should be taken under consideration to ensure optimal dose delivery. Available edema models, based on prostate volume observations, face several limitations. Therefore, patient-specific models need to be developed to accurately account for the impact of edema. In this study we present a biomechanical model developed to reproduce edema resolution patterns documented in the literature. Using the biphasic mixture theory and finite element analysis, the proposed model takes into consideration the mechanical properties of the pubic area tissues in the evolution of prostate edema...
January 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28140338/a-monte-carlo-study-of-i-125-prostate-brachytherapy-with-gold-nanoparticles-dose-enhancement-with-simultaneous-rectal-dose-sparing-via-radiation-shielding
#19
D Brivio, P L Nguyen, E Sajo, W Ngwa, P Zygmanski
We investigate via Monte Carlo simulations a new (125)I brachytherapy treatment technique for high-risk prostate cancer patients via injection of Au nanoparticle (AuNP) directly into the prostate. The purpose of using the nanoparticles is to increase the therapeutic index via two synergistic effects: enhanced energy deposition within the prostate and simultaneous shielding of organs at risk from radiation escaping from the prostate. Both uniform and non-uniform concentrations of AuNP are studied. The latter are modeled considering the possibility of AuNP diffusion after the injection using brachy needles...
March 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28139422/salvage-of-locally-recurrent-prostate-cancer-after-external-beam-radiation-using-reduced-dose-brachytherapy-with-neoadjuvant-plus-adjuvant-androgen-deprivation
#20
Brian C Baumann, John C Baumann, John P Christodouleas, Edward Soffen
PURPOSE: Local recurrence (LR) of prostate cancer after external beam radiotherapy (EBRT) is a serious problem. Our purpose was to determine if reduced-dose salvage brachytherapy could achieve high rates of biochemical control with acceptable toxicity if combined with androgen deprivation therapy (ADT). METHODS AND MATERIALS: Thirty-three consecutive patients with LR after EBRT were treated with salvage brachytherapy plus ADT from 1998 to 2013. All had pathologically confirmed LR, disease-free interval ≥18 months after EBRT, no distant/nodal metastasis, and International Prostate Symptom Score ≤15...
January 27, 2017: Brachytherapy
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