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Prostate brachytherapy

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https://www.readbyqxmd.com/read/28816169/long-term-results-of-a-randomized-trial-comparing-iridium-implant-plus-external-beam-radiation-therapy-with-external-beam-radiation-therapy-alone-in-node-negative-locally-advanced-cancer-of-the-prostate
#1
Ian S Dayes, Sameer Parpia, Jaclyn Gilbert, Jim A Julian, Ian R Davis, Mark N Levine, Jinka Sathya
PURPOSE: To determine the impact on long-term survival from the addition of brachytherapy to external beam radiation therapy (EBRT) in patients with prostate cancer. METHODS AND MATERIALS: Between 1992 and 1997, 104 men with cT2-3, surgically staged node-negative prostate cancer were randomized to receive either EBRT (40 Gy/20 fractions) with iridium implant (35 Gy/48 hours) or EBRT alone (66 Gy/33 fractions) to the prostate. According to T stage, Gleason score, and prostate-specific antigen level, 60% of patients had high-risk disease...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28807747/pretreatment-3t-multiparametric-mri-staging-predicts-for-biochemical-failure-in-high-risk-prostate-cancer-treated-with-combination-high-dose-rate-brachytherapy-and-external-beam-radiotherapy
#2
John V Hegde, D Jeffrey Demanes, Darlene Veruttipong, Jagdeep Raince, Sang-June Park, Steven S Raman, Nicholas G Nickols, Christopher R King, Amar U Kishan, Michael L Steinberg, Mitchell Kamrava
PURPOSE: To determine whether pretreatment 3T multiparametric MRI (mpMRI) staging impacts biochemical recurrence-free survival (BRFS) or distant metastasis-free survival (DMFS) for men with high-risk prostate cancer treated with combination high-dose-rate (HDR) brachytherapy and external beam radiation therapy (EBRT). MATERIALS AND METHODS: This institutional review board-approved retrospective study included a cohort of 37 men with high-risk prostate cancer treated with HDR brachytherapy and EBRT after 3T mpMRI...
August 11, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28807532/multicenter-evaluation-of-biochemical-relapse-free-survival-outcomes-for-intraoperatively-planned-prostate-brachytherapy-using-an-automated-delivery-system
#3
Kevin Martell, Siraj Husain, Daniel Taussky, Steve Angyalfi, Guila Delouya, Philippe Després, Luc Beaulieu, Andre-Guy Martin, Eric Vigneault
PURPOSE: To report biochemical recurrence in prostate cancer treated with intraoperatively planned low-dose-rate prostate brachytherapy using an automated delivery system (IO-LDRB). METHODS AND MATERIALS: Between 2003 and 2013, 2608 patients from 3 centers were treated with IO-LDRB as single-modality treatment for low or low-tier intermediate-risk prostate cancer. Databases from the 3 centers have been analyzed. These independent databases were collected prospectively...
June 6, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28806948/assessment-of-lower-urinary-symptom-flare-with-overactive-bladder-symptom-score-and-international-prostate-symptom-score-in-patients-treated-with-iodine-125-implant-brachytherapy-long-term-follow-up-experience-at-a-single-institute
#4
Makito Miyake, Nobumichi Tanaka, Isao Asakawa, Shunta Hori, Yosuke Morizawa, Yoshihiro Tatsumi, Yasushi Nakai, Takeshi Inoue, Satoshi Anai, Kazumasa Torimoto, Katsuya Aoki, Masatoshi Hasegawa, Tomomi Fujii, Noboru Konishi, Kiyohide Fujimoto
BACKGROUND: The aim of this study was to evaluate the combined use of the overactive bladder symptom score (OABSS) and International Prostate Symptom Score (IPSS) as an assessment tool for urinary symptom flare after iodine-125 ((125)I) implant brachytherapy. The association between urinary symptom flare and prostate-specific antigen (PSA) bounce was investigated. METHODS: Changes in the IPSS and OABSS were prospectively recorded in 355 patients who underwent seed implantation...
August 14, 2017: BMC Urology
https://www.readbyqxmd.com/read/28802187/radiotherapy-access-in-belgium-how-far-are-we-from-evidence-based-utilisation
#5
Y Lievens, H De Schutter, K Stellamans, M Rosskamp, L Van Eycken
INTRODUCTION: Underutilisation of radiotherapy has been observed worldwide. To evaluate the current situation in Belgium, optimal utilisation proportions (OUPs) adopted from the European SocieTy for Radiotherapy and Oncology - Health Economics in Radiation Oncology (ESTRO-HERO) project were compared to actual utilisation proportions (AUPs) and with radiotherapy advised during the multidisciplinary cancer team (MDT) meetings. In addition, the impact of independent variables was analysed...
August 9, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28777451/challenges-in-mr-only-seed-localization-for-postimplant-dosimetry-in-permanent-prostate-brachytherapy
#6
Frank Zijlstra, Marinus A Moerland, Jochem R N van der Voort van Zyp, Juus L Noteboom, Max A Viergever, Peter R Seevinck
PURPOSE: An MR-only postimplant dosimetry workflow for low dose rate (LDR) brachytherapy could reduce patient burden, improve accuracy, and improve cost efficiency. However, localization of brachytherapy seeds on MRI scans remains a major challenge for this type of workflow. In this study, we propose and validate an MR-only seed localization method, and identify remaining challenges. METHODS AND MATERIALS: The localization method was based on template matching of simulations of complex-valued imaging artifacts around metal brachytherapy seeds...
August 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28764882/accuracy-and-variability-of-high-dose-rate-prostate-brachytherapy-needle-tip-localization-using-live-two-dimensional-and-sagittally-reconstructed-three-dimensional-ultrasound
#7
William Thomas Hrinivich, Douglas A Hoover, Kathleen Surry, Chandima Edirisinghe, Vikram Velker, Glenn Bauman, David D'Souza, Aaron Fenster, Eugene Wong
PURPOSE: To measure the accuracy and variability of manual high-dose-rate (HDR) prostate brachytherapy (BT) needle tip localization using sagittally reconstructed three-dimensional (3D) transrectal ultrasound (TRUS) augmented with live two-dimensional (2D) sagittal TRUS. METHODS AND MATERIALS: Ten prostate cancer patients underwent HDR-BT during which the sagittally assisted sagittally reconstructed (SASR) segmentation technique was completed in parallel with commercially available sagittally assisted axially reconstructed (SAAR) TRUS for comparison...
July 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28764881/dosimetric-impact-of-intrafraction-changes-in-mr-guided-high-dose-rate-hdr-brachytherapy-for-prostate-cancer
#8
Alexandra Rink, Jette Borg, Anna Simeonov, Gerald O'Leary, Joelle Helou, Cynthia Ménard, Peter Chung, David A Jaffray, Alejandro Berlin
PURPOSE: To assess changes in implant and treatment volumes through the course of a prostate high-dose-rate brachytherapy procedure and their impact on plan quality metrics. METHODS AND MATERIALS: Sixteen MRI-guided high-dose-rate procedures included a post-treatment MR (ptMR) immediately after treatment delivery (135 min between MR scans). Target and organs at risk (OARs) were contoured, and catheters were reconstructed. The delivered treatment plan was applied to the ptMR image set...
July 29, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28763873/-long-term-oncologic-outcomes-of-localized-high-risk-prostate-cancer-undergoing-brachytherapy-combined-with-external-beam-radiation-therapy-and-maximal-androgen-blockade
#9
Y Luo, M C Li, H Z Qi, J H Zhao, Y L Han, Y H Lin, Z Hou, Y G Jiang
Objective: To investigate the oncologic outcome and PSA kinetics of localized high-risk prostate cancer (PCa) patients treated with combination strategy of radiation therapy (RT) and maximal androgen blockade (MAB). Methods: We retrospectively reviewed the clinical data of 320 localized PCa patients undergoing RT+ MAB from 2001 to 2015. And radiation treatment protocol consisted of permanent prostate brachytherapy (PPB) at 110 Gy and EBRT at 45 Gy/23 fractions. Results: The median follow-up time was 90 (range: 12-186) months...
July 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28760484/pulsed-dose-rate-brachytherapy-for-pediatric-bladder-prostate-rhabdomyosarcoma-compliance-and-early-clinical-results
#10
Cyrus Chargari, Hélène Martelli, Florent Guérin, Warren Bacorro, Guénolée de Lambert, Alexandre Escande, Véronique Minard-Colin, Isabelle Dumas, Eric Deutsch, Christine Haie-Meder
OBJECTIVE: No data are available on the feasibility of pulsed dose rate (PDR) brachytherapy in very young children. Our experience of PDR brachytherapy for bladder prostate (BP) rhabdomyosarcoma (RMS) is reported, with focus on compliance and dosimetric parameters. MATERIALS AND METHODS: Treatment parameters and outcome of consecutive BP RMS patients treated in our center were examined. Treatment was carried out as part of a multimodal conservative radio-surgical treatment...
July 28, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28757403/performance-of-a-palladium-103-line-source-for-prostate-brachytherapy-implants-a-phase-i-trial
#11
Richard Stock, David Beyer, Jed Kaminetsky, William Ge
PURPOSE: To evaluate the use of a polymer-encapsulated palladium-103 ((103) Pd) source with a unique linear radioactive distribution in prostate brachytherapy. This feasibility study assessed dosimetry, ease and efficiency of use, and side effects. The number of needles required for adequate coverage was the primary end point. METHODS AND MATERIALS: CivaString (103) Pd Model CS10 implants were preplanned for 25 patients. CivaStrings were custom manufactured according to plan...
July 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28757402/brachytherapy-patient-safety-events-in-an-academic-radiation-medicine%C3%A2-program
#12
Shira Felder, Lyndon Morley, Elizabeth Ng, Kitty Chan, Heather Ballantyne, Anne Di Tomasso, Jette Borg, Jean-Pierre Bissonnette, Stephen Breen, John Waldron, Alexandra Rink, Michael Milosevic
PURPOSE: To describe the incidence and type of brachytherapy patient safety events over 10 years in an academic brachytherapy program. METHODS AND MATERIALS: Brachytherapy patient safety events reported between January 2007 and August 2016 were retrieved from the incident reporting system and reclassified using the recently developed National System for Incident Reporting in Radiation Treatment taxonomy. A multi-incident analysis was conducted to identify common themes and key learning points...
July 27, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28757301/quality-of-life-outcomes-after-primary-treatment-for-clinically-localised-prostate-cancer-a-systematic-review
#13
REVIEW
Michael Lardas, Matthew Liew, Roderick C van den Bergh, Maria De Santis, Joaquim Bellmunt, Thomas Van den Broeck, Philip Cornford, Marcus G Cumberbatch, Nicola Fossati, Tobias Gross, Ann M Henry, Michel Bolla, Erik Briers, Steven Joniau, Thomas B Lam, Malcolm D Mason, Nicolas Mottet, Henk G van der Poel, Olivier Rouvière, Ivo G Schoots, Thomas Wiegel, Peter-Paul M Willemse, Cathy Yuhong Yuan, Liam Bourke
CONTEXT: Current evidence-based management for clinically localised prostate cancer includes active surveillance, surgery, external beam radiotherapy (EBRT) and brachytherapy. The impact of these treatment modalities on quality of life (QoL) is uncertain. OBJECTIVE: To systematically review comparative studies investigating disease-specific QoL outcomes as assessed by validated cancer-specific patient-reported outcome measures with at least 1 yr of follow-up after primary treatment for clinically localised prostate cancer...
July 27, 2017: European Urology
https://www.readbyqxmd.com/read/28755922/brachytherapy-improves-outcomes-in-young-men-%C3%A2-60-years-with-prostate-cancer-a-seer-analysis
#14
Hani Ashamalla, Adel Guirguis, Kyle McCool, Shauna McVorran, Malcolm Mattes, Daniel Metzger, Clara Oromendia, Karla V Ballman, Bahaa Mokhtar, Mounzer Tchelebi, Evangelia Katsoulakis, Sameer Rafla
No abstract text is available yet for this article.
July 2017: Brachytherapy
https://www.readbyqxmd.com/read/28754301/high-dose-rate-brachytherapy-boost-for-prostate-cancer-comparison-of-three-different-fractionation-schemes
#15
Alexander T Falk, Sylvain Demontoy, Emmanuel Chamorey, Marie-Eve Chand, Mathieu Gautier, David Azria, Sara Zaki, Daniel Chevallier, Daniel Lam Cham Kee, Jean-Michel Hannoun-Lévi
PURPOSE: Dose escalation for prostate cancer can be achieved with a combination of external beam radiotherapy (EBRT) and brachytherapy (BT) boost to increase local control. For high-dose-rate (HDR)-BT, optimal fractionation remains under debate. The objective was to assess the clinical outcome of three schemes of HDR-BT boost. METHODS AND MATERIALS: Retrospective single institution data collection was performed. Patients received 46 Gy EBRT then an HDR-BT boost: 3 × 6 Gy, 2 × 9 Gy, or 1 × 14 Gy...
July 25, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28749017/large-institutional-variations-in-androgen-deprivation-therapy-utilization-with-definitive-radiotherapy-in-a-population-based-cohort-of-men-with-intermediate-and-high-risk-prostate-cancer
#16
Wee Loon Ong, Farshad Foroudi, Sue Evans, Jeremy Millar
OBJECTIVE: To evaluate the pattern of androgen deprivation therapy (ADT) utilization with definitive radiotherapy (RT) in men with prostate cancer (CaP) in a population-based study in Australia PATIENTS AND METHODS: This is a prospective cohort of men with intermediate and high-risk CaP captured in the population-based Prostate Cancer Outcome Registry Victoria (PCOR-Vic) treated with definitive prostate RT between January 2010 and December 2015. The primary outcome of interest is ADT utilization...
July 27, 2017: BJU International
https://www.readbyqxmd.com/read/28743617/can-the-day-0-ct-scan-predict-the-post-implant-scanning-results-from-136-prostate-cancer-patients
#17
Federica Cattani, Andrea Vavassori, Stefania Comi, Federica Gherardi, Stefania Russo, Roberto Orecchia, Barbara A Jereczek-Fossa
PURPOSE: Post-implant CT-scanning is an essential part of permanent prostate brachytherapy. However, the evaluation of post-implant CT dosimetry is not straightforward due to the edema that can modify the dose to the prostate and to the organs at risk. The aim of this study is to evaluate the impact of the timing of the post-implant CT-scan on the dosimetric results and to verify if the Day 0 scan findings can predict Day 50 scanning. METHODS: 136 consecutive patients who received monotherapy with I-125 implants were selected for this study...
July 22, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28740903/hypofractionated-image-guided-radiation-therapy-followed-by-prostate-seed-implant-boost-for-men-with-newly-diagnosed-intermediate-and-high-risk-adenocarcinoma-of-the-prostate-preliminary-results-of-a-phase-2-prospective-study
#18
Steven Gresswell, Rodney E Wegner, Day Werts, Ralph Miller, Russell Fuhrer
PURPOSE: A phase 2 protocol was designed and implemented to assess the toxicity and efficacy of hypofractionated image guided intensity modulated radiation therapy (IG-IMRT) combined with low-dose rate (103)Pd prostate seed implant for treatment of localized intermediate- and high-risk adenocarcinoma of the prostate. METHODS AND MATERIALS: This is a report of an interim analysis on 24 patients enrolled on an institutional review board-approved phase 2 single-institution study of patients with intermediate- and high-risk adenocarcinoma of the prostate...
October 2016: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28730606/technical-note-empirical-altitude-correction-factors-for-well-chamber-measurements-of-permanent-prostate-and-breast-seed-implant-sources
#19
Elizabeth Watt, David P Spencer, Tyler Meyer
PURPOSE: Previous studies in the literature have measured an altitude effect for low-energy brachytherapy seeds; a correction factor applied in addition to PTP to account for the breakdown of Bragg-Gray cavity theory at low energies in well-type ionization chambers. In clinical practice, many centres use altitude correction factors that are not seed-model-specific. The purpose of this work is to present altitude correction factors for several seed models without documented factors in the literature...
July 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28725242/focal-application-of-low-dose-rate-brachytherapy-for-prostate-cancer-a-pilot-study
#20
S Sara Mahdavi, Ingrid T Spadinger, Septimiu E Salcudean, Piotr Kozlowski, Silvia D Chang, Tony Ng, Julio Lobo, Guy Nir, Hamid Moradi, Michael Peacock, W James Morris
PURPOSE: To evaluate the feasibility and to report the early outcomes of focal treatment of prostate cancer using low-dose-rate brachytherapy (LDR-PB). MATERIAL AND METHODS: Seventeen patients were screened with multi-parametric magnetic resonance imaging (mpMRI), 14 of whom proceeded to receive trans-perineal template mapping biopsy (TTMB). Focal LDR-PB was performed on five eligible patients using dual air kerma strength treatment plans based on planning target volumes derived from cancer locations and determined by TTMB...
June 2017: Journal of Contemporary Brachytherapy
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