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Prostate brachytherapy

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https://www.readbyqxmd.com/read/29339806/tumor-characteristics-treatments-and-oncological-outcomes-of-prostate-cancer-in-men-aged-%C3%A2-50-years-a-population-based-study
#1
Raisa S Pompe, Ariane Smith, Marco Bandini, Michele Marchioni, Tristan Martel, Felix Preisser, Sami-Ramzi Leyh-Bannurah, Jonas Schiffmann, Fred Saad, Hartwig Huland, Markus Graefen, Shahrokh F Shariat, Derya Tilki, Pierre I Karakiewicz
BACKGROUND: To examine clinical characteristics, treatment modalities and oncological outcomes of prostate cancer (PCa) according to young (≤50) vs. old age. METHODS: Of 407,599 men with primary adenocarcinoma of the prostate within the Surveillance, Epidemiology and End Results (SEER)-database (2004 to 2013), 18,387 were aged ≤50 years (4.5%). Time trends, cumulative incidence, and competing risks regression (CRR) analyses tested for differences between young and old patients...
January 16, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29339046/stereotactic-body-radiation-therapy-sbrt-for-high-risk-prostate-cancer-where-are-we-now
#2
REVIEW
Alejandro Gonzalez-Motta, Mack Roach
PURPOSE: Stereotactic body radiation therapy (SBRT) is increasingly being used for the management of localized prostate cancer. This trend combined with declining use of brachytherapy (BT) has pushed issues and questions regarding the use of SBRT to the forefront. A systematic literature review was conducted to review the current evidence of biochemical disease-free survival (bDFS) and toxicity of SBRT in high-risk (HR) prostate cancer. METHODS AND MATERIALS: A search was carried out on the PubMed and Embase databases...
December 2, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29333958/focal-mri-guided-salvage-high-dose-rate-brachytherapy-in-patients-with-radiorecurrent-prostate-cancer
#3
Metha Maenhout, Max Peters, Marco van Vulpen, Marinus A Moerland, Richard P Meijer, Maurice A A J van den Bosch, Paul L Nguyen, Steven J Frank, Jochem R N van der Voort van Zyp
INTRODUCTION: Whole-gland salvage treatment of radiorecurrent prostate cancer has a high rate of severe toxicity. The standard of care in case of a biochemical recurrence is androgen deprivation treatment, which is associated with morbidity and negative effects on quality of life. A salvage treatment with acceptable toxicity might postpone the start of androgen deprivation treatment, might have a positive influence on the patients' quality of life, and might even be curative. Here, toxicity and biochemical outcome are described after magnetic resonance imaging-guided focal salvage high-dose-rate brachytherapy in patients with radiorecurrent prostate cancer...
December 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/29331575/validation-of-mri-to-trus-registration-for-high-dose-rate-prostate-brachytherapy
#4
Eric Poulin, Karim Boudam, Csaba Pinter, Samuel Kadoury, Andras Lasso, Gabor Fichtinger, Cynthia Ménard
PURPOSE: The objective of this study was to develop and validate an open-source module for MRI to transrectal ultrasound (TRUS) registration to support tumor-targeted prostate brachytherapy. METHODS AND MATERIALS: In this study, 15 patients with prostate cancer lesions visible on multiparametric MRI were selected for the validation. T2-weighted images with 1-mm isotropic voxel size and diffusion weighted images were acquired on a 1.5T Siemens imager. Three-dimensional (3D) TRUS images with 0...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29319928/low-dose-rate-brachytherapy-for-prostate-cancer-outcomes-beyond-10-years-of-follow-up
#5
S Lazarev, M R Thompson, N N Stone, R G Stock
OBJECTIVES: To examine biochemical control, survival, and late morbidity with definitive low-dose-rate brachytherapy (LDR-BT) for prostate cancer patients surviving ≥10 years post-treatment. MATERIALS AND METHODS: We identified 757 men with localized prostate cancer who underwent definitive LDR-BT in the period 1990-2006 and were followed for ≥10 years at our institution. Biochemical failure-free survival (BFFS), distant metastases-free survival (DMFS), disease-specific survival (DSS), and overall survival (OS) were selected as study endpoints...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29319919/outcomes-and-toxicities-in-intermediate-risk-prostate-cancer-patients-treated-with-brachytherapy-alone-or-brachytherapy-and-supplemental-external-beam-radiation-therapy
#6
Emily Schlussel Markovic, Michael Buckstein, Nelson N Stone, Richard G Stock
OBJECTIVE: To evaluate the cancer control outcomes and long-term treatment-related morbidity of brachytherapy as well as combination brachytherapy and EBRT in patients with intermediate-risk prostate cancer. MATERIALS AND METHODS: A retrospective review was conducted in a prospectively collected database of patients with intermediate-risk prostate cancer who were treated either with brachytherapy or brachytherapy and EBRT, with or without ADT, from 1990-2014. Urinary and erectile dysfunction symptoms are measured using the International Prostate Symptom Score (IPSS) and the Mount Sinai erectile function scale, and the Sexual Health Inventory for Men (SHIM), respectively...
January 10, 2018: BJU International
https://www.readbyqxmd.com/read/29317377/multiparametric-mri-for-the-detection-of-local-recurrence-of-prostate-cancer-in-the-setting-of-biochemical-recurrence-after-low-dose-rate-brachytherapy
#7
Luca F Valle, Matthew D Greer, Joanna H Shih, Tristan Barrett, Yan Mee Law, Andrew B Rosenkrantz, Haytham Shebel, Akhil Muthigi, Daniel Su, Maria J Merino, Bradford J Wood, Peter A Pinto, Andra V Krauze, Aradhana Kaushal, Peter L Choyke, Barış Türkbey, Deborah E Citrin
PURPOSE: Prostate multiparametric magnetic resonance imaging (mpMRI) has utility in detecting post-radiotherapy local recurrence. We conducted a multireader study to evaluate the diagnostic performance of mpMRI for local recurrence after low dose rate (LDR) brachytherapy. METHODS: A total of 19 patients with biochemical recurrence after LDR brachytherapy underwent 3T endorectal coil mpMRI with T2-weighted imaging, dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI) with pathologic confirmation...
January 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29314535/low-dose-rate-prostate-brachytherapy-in-younger-men
#8
EDITORIAL
Nelson Stone
No abstract text is available yet for this article.
January 2018: BJU International
https://www.readbyqxmd.com/read/29306674/a-comparison-of-early-prostate-specific-antigen-decline-between-prostate-brachytherapy-and-different-fractionation-of-external-beam-radiation-impact-on-biochemical-failure
#9
Daniel Taussky, Stéphane Bedwani, Nissan Meissner, Jean-Paul Bahary, Carole Lambert, Maroie Barkati, Marie-Claude Beauchemin, Cynthia Ménard, Guila Delouya
PURPOSE: The aim of this study was to compare early prostate-specific antigen (PSA) decline patterns and PSA nadirs between low-dose-rate seed prostate brachytherapy (LDR-PB) and different fractionations of external beam radiotherapy (EBRT) and their predictive importance for biochemical failure (bF). METHODS AND MATERIALS: Patients with D'Amico low- or intermediate-risk prostate cancer who underwent a single-modality treatment without androgen deprivation were included in this study...
January 3, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29296018/prostate-cancer-radiation-and-urethral-strictures-a-systematic-review-and-meta-analysis
#10
Mohannad A Awad, Thomas W Gaither, E Charles Osterberg, Gregory P Murphy, Nima Baradaran, Benjamin N Breyer
BACKGROUND: We performed a systematic review and meta-analysis to determine the prevalence and predictors of urethral stricture development post radiation therapy (RT) for prostate cancer (PCa). METHODS: Published articles in PubMed/Medline, Cochrane, and Embase databases from January 2000 to April 2016 were queried. Inclusion criteria were any study that reported the prevalence of urethral strictures following external beam radiation therapy (EBRT), brachytherapy (BT), or both as a primary treatment for PCa...
January 2, 2018: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/29287618/re-brachytherapy-for-patients-with-prostate-cancer-american-society-of-clinical-oncology-cancer-care-ontario-joint-guideline-update
#11
Alberto Bossi
No abstract text is available yet for this article.
December 26, 2017: European Urology
https://www.readbyqxmd.com/read/29281088/prediction-of-acute-gastrointestinal-and-genitourinary-radiation-toxicity-in-prostate-cancer-patients-using-lymphocyte-microrna
#12
Masanori Someya, Masakazu Hori, Toshio Gocho, Kensei Nakata, Takaaki Tsuchiya, Mio Kitagawa, Tomokazu Hasegawa, Yuuki Fukushima, Koh-Ichi Sakata
Background: To search for novel biomarkers that can predict acute radiation toxicity, we conducted microRNA expression analysis of peripheral blood lymphocytes (PBLs). Methods: The discovery cohort was 69 patients with localized adenocarcinoma of the prostate who received intensity-modulated radiation therapy between October 2007 and October 2010. The validation cohort was 72 patients treated with low-dose-rate brachytherapy between May 2008 and March 2014. After13 microRNAs were selected by TaqMan® Array analysis in a preliminary experiment, expression of these microRNAs in all samples was analyzed by RT-PCR...
December 21, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29276060/brachytherapy-monotherapy-may-be-sufficient-for-a-subset-of-patients-with-unfavorable-intermediate-risk-prostate-cancer
#13
Martin T King, Ming-Hui Chen, Brian J Moran, Michelle H Braccioforte, Ivan Buzurovic, Vinayak Muralidhar, David D Yang, Kent W Mouw, Phillip M Devlin, Anthony V D'Amico, Paul L Nguyen, Peter F Orio
PURPOSE/OBJECTIVE(S): Brachytherapy (BT) monotherapy is a well-established treatment modality for favorable intermediate risk (FIR) prostate cancer. However, patients with unfavorable intermediate risk (UIR) disease are often recommended trimodality therapy involving BT, androgen deprivation therapy (ADT), and external beam radiation therapy (EBRT). We sought to investigate the relative benefit of supplemental therapies (ADT and/or EBRT) for FIR and UIR prostate cancer in a large dataset...
December 21, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29275307/challenges-in-the-analysis-of-outcomes-for-surgical-compared-to-radiotherapy-treatment-of-prostate-cancer
#14
Scott M Glaser, Ronny Kalash, Dante R Bongiorni, Mark S Roberts, Goundappa K Balasubramani, Bruce L Jacobs, Sushil Beriwal, Dwight E Heron, Joel S Greenberger
BACKGROUND/AIM: Prostate cancer can be treated with radical prostatectomy (RP), external-beam radiotherapy (EBRT), or brachytherapy (BT). These modalities have similar cancer-related outcomes. We used an innovative method to analyze the cost of such treatment. MATERIALS AND METHODS: We queried our Institution's Insurance Division [University of Pittsburgh Medical Center (UPMC) Health Plan] beneficiaries from 2003-2008, who were diagnosed with prostate cancer and also queried the UPMC tumor registry for all patients with prostate cancer treated at our Institution...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29275049/the-multiple-slit-technique-must-for-penile-length-and-girth-restoration
#15
Paulo H Egydio, Franklin E Kuehhas
BACKGROUND: Patients with severe erectile dysfunction (ED) and penile size issues, especially seen in Peyronie's disease (PD), are candidates for more invasive penile prosthesis insertion techniques that aim for penile length and girth reconstruction. AIM: To present the feasibility and safety of penile length and girth restoration based on the so-called multiple-slit technique (MUST) for patients with severe ED and significant penile shortening with or without PD...
December 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29273727/radiosensitization-of-prostate-cancers-in-vitro-and-in-vivo-to-erbium-filtered-orthovoltage-x-rays-using-actively-targeted-gold-nanoparticles
#16
Allison M Khoo, Sang Hyun Cho, Francisco J Reynoso, Maureen Aliru, Kathryn Aziz, Monica Bodd, Xi Yang, Md F Ahmed, Selcuk Yasar, Nivedh Manohar, Jongmin Cho, Ramesh Tailor, Howard D Thames, Sunil Krishnan
Theoretical investigations suggest that gold nanoparticle (GNP)-mediated radiation dose enhancement and radiosensitization can be maximized when photons interact with gold, predominantly via photoelectric absorption. This makes ytterbium (Yb)-169, which emits photons with an average energy of 93 keV (just above the K-edge of gold), an ideal radioisotope for such purposes. This investigation tests the feasibility of tumor-specific prostate brachytherapy achievable with Yb-169 and actively targeted GNPs, using an external beam surrogate of Yb-169 created from an exotic filter material - erbium (Er) and a standard copper-filtered 250 kVp beam...
December 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29260727/dosimetric-impact-of-dual-energy-ct-tissue-segmentation-for-low-energy-prostate-brachytherapy-a-monte-carlo-study
#17
Charlotte Remy, Arthur Lalonde, Dominic Béliveau-Nadeau, Jean-Francois Carrier, Hugo Bouchard
{\color{red}The purpose of this study is} to evaluate the impact of a novel tissue characterization method using dual-energy over single-energy computed tomography (DECT and SECT) on Monte Carlo (MC) dose calculations for low-dose rate (LDR) prostate brachytherapy performed in a patient like geometry. A virtual patient geometry is created using contours from a real patient pelvis CT scan, where known elemental compositions and varying densities are overwritten in each voxel. A second phantom is made with additional calcifications...
December 20, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29251165/prostate-cancer-high-dose-rate-brachytherapy-review-of-evidence-and-current-perspectives
#18
Sunil W Dutta, Clayton E Alonso, Bruce Libby, Timothy N Showalter
Patients with intermediate to high risk disease (prostate specific antigen (PSA) ≥ 10, Gleason score ≥ 7, or clinical stage ≥ T2b) suffer from poorer long-term biochemical control (freedom from an increasing prostate specific antigen level) when treated with external beam radiation (EBRT) alone. In order to improve biochemical control while limiting long-term complications, brachytherapy has been incorporated into radiotherapy treatment, either alone or in combination with EBRT. Areas covered: Current literature regarding the use of high dose-rate (HDR) brachytherapy for localized prostate cancer, including as a boost and monotherapy...
December 22, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29249526/curative-radiation-therapy-at-time-of-progression-under-active-surveillance-compared-with-up-front-radical-radiation-therapy-for-prostate-cancer
#19
Alejandro Berlin, Ardalan E Ahmad, Melvin L K Chua, Fabio Y Moraes, Haiyan Jiang, Maria Komisarenko, Narhari Trimilshina, Hamid Raziee, Ali Hosni, Jure Murgic, Peter Chung, Robert G Bristow, Antonio Finelli
PURPOSE: To describe and compare outcomes in men with initially presumed indolent prostate cancer receiving definitive radiation therapy after active surveillance (AS) versus those in a risk-matched cohort undergoing up-front radiation therapy. METHODS AND MATERIALS: Men prospectively enrolled in an AS program between 1992 and 2014 and subsequently undergoing curative radiation therapy (ie, image guided radiation therapy [IGRT] or low-dose-rate brachytherapy [LDR-BT]) were identified...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29241706/placement-of-an-absorbable-rectal-hydrogel-spacer-in-patients-undergoing-low-dose-rate-brachytherapy-with-palladium-103
#20
Amandeep S Taggar, Tomer Charas, Gil'ad N Cohen, Keeratikarn Boonyawan, Marisa Kollmeier, Sean McBride, Nitin Mathur, Antonio L Damato, Michael J Zelefsky
PURPOSE: Rates of rectal toxicity after low-dose-rate (LDR) brachytherapy for prostate cancer are dependent on rectal dose, which is associated with rectal distance from prostate and implanted seeds. Placement of a hydrogel spacer between the prostate and rectum has proven to reduce the volume of the rectum exposed to higher radiation dose levels in the setting of external beam radiotherapy. We present our findings with placing a rectal hydrogel spacer in patients following LDR brachytherapy, and we further assess the impact of this placement on dosimetry and acute rectal toxicity...
December 11, 2017: Brachytherapy
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