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https://www.readbyqxmd.com/read/29214336/the-efficacy-and-safety-of-early-postoperative-botulinum-toxin-a-injection-for-facial-scars
#1
Seo H Lee, Hyung J Min, Yang W Kim, Young W Cheon
BACKGROUND: Scars widen when the underlying musculature pulls apart suture lines, and scars oriented against relaxed skin tension lines are especially susceptible to these distraction forces. Because botulinum toxin A (BTA) induces complete muscle paralysis, the purpose of the current study was to evaluate the effects of BTA using both observer-dependent qualitative assessments and quantitative measurements to verify its beneficial effects on facial scarring. METHODS: Patients with vertical forehead lacerations, treated by primary closure, were randomly assigned to two groups: one (n = 15) received BTA injections within 5 days of primary closure and the other (n = 15) received no further treatment...
December 6, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/29185756/supramolecular-polymerization-of-n-n-n-n-tetra-tetradecyl-1-3-6-8-pyrenetetracarboxamide-a-computational-study
#2
Divya Bharathi Korlepara, Karteek K Bejagam, Sundaram Balasubramanian
The role of molecular dipole orientations and intermolecular interactions in a derivative of pyrene on its supramolecular self assembly in solution has been investigated using quantum chemical and force field based computational approaches. Five possible dipole configurations of the molecule have been examined, among which the one in which adjacent dipole vectors are antiparallel to each other is determined to be the ground state, on electrostatic grounds. Self-assembly of this molecule under realistic conditions has been studied using MD simu- lations...
November 29, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29171499/-treatment-of-spasticity-after-traumatic-brain-injury-in-children-the-role-of-botulinum-toxin-therapy
#3
O A Klochkova, A L Kurenkov, N A Mamontova
Traumatic brain injury (TBI) is one of the main reasons of death and disability in children and adolescents in Russia and abroad. Spasticity is a frequent outcome of the TBI that influences on the rehabilitation prognosis, degree of movement disorders and quality of life after trauma. Early spasticity correction and complex rehabilitation lead to the optimal recovery and prevent secondary complications. This review presents the current data about the prognostic role of the spasticity in children after TBI, methods of its correction and their scientific evidence...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29151619/improving-the-folding-of-supramolecular-copolymers-by-controlling-the-assembly-pathway-complexity
#4
Gijs M Ter Huurne, Lafayette N J de Windt, Yiliu Liu, E W Meijer, Ilja K Voets, Anja R A Palmans
A family of amphiphilic, heterograft copolymers containing hydrophilic, hydrophobic, and supramolecular units based on Jeffamine M-1000, dodecylamine, and benzene-1,3,5-tricarboxamide (BTA) motifs, respectively, was prepared via a postfunctionalization approach. The folding of the copolymers in water into nanometer-sized particles was analyzed by a combination of dynamic and static light scattering, circular dichroism spectroscopy, and small-angle neutron scattering. The sample preparation protocol was crucial for obtaining reproducible and consistent results, showing that only full control over the structure and pathway complexity will afford the desired folded structure, a phenomenon similar to protein folding...
November 14, 2017: Macromolecules
https://www.readbyqxmd.com/read/29143708/genome-wide-association-study-for-growth-traits-in-nelore-cattle
#5
A P N Terakado, R B Costa, G M F de Camargo, N Irano, T Bresolin, L Takada, C V D Carvalho, H N Oliveira, R Carvalheiro, F Baldi, L G de Albuquerque
The objective of this study was to investigate the association of single nucleotide polymorphisms (SNPs) with birth weight, weight gain from birth to weaning and from weaning to yearling, yearling height and cow weight in Nelore cattle. Data from 5064 animals participating in the DeltaGen and PAINT breeding programs were used. The animals were genotyped with a panel of 777 962 SNPs (Illumina BovineHD BeadChip) and 412 993 SNPs remained after quality control analysis of the genomic data. A genome-wide association study was performed using a single-step methodology...
November 16, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29128211/genome-wide-association-studies-to-identify-quantitative-trait-loci-affecting-milk-production-traits-in-water-buffalo
#6
J J Liu, A X Liang, G Campanile, G Plastow, C Zhang, Z Wang, A Salzano, B Gasparrini, M Cassandro, L G Yang
Water buffalo is the second largest resource of milk supply around the world, and it is well known for its distinctive milk quality in terms of fat, protein, lactose, vitamin, and mineral contents. Understanding the genetic architecture of milk production traits is important for future improvement by the buffalo breeding industry. The advance of genome-wide association studies (GWAS) provides an opportunity to identify potential genetic variants affecting important economical traits. In the present study, GWAS was performed for 489 buffaloes with 1,424 lactation records using the 90K Affymetrix Buffalo SNP Array (Affymetrix/Thermo Fisher Scientific, Santa Clara, CA)...
November 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29106766/antioxidant-responses-and-deregulation-of-epigenetic-writers-and-erasers-link-oxidative-stress-and-dna-methylation-in-bovine-blastocysts
#7
Monalisa M Bomfim, Gabriella M Andrade, Maite Del Collado, Juliano R Sangalli, Patrícia K Fontes, Marcelo F G Nogueira, Flávio V Meirelles, Juliano C da Silveira, Felipe Perecin
Early mammalian embryos derived from in vitro fertilization are exposed to conditions distinct from the native oviduct-uterine environment, including atmospheric oxygen that promotes cellular oxidative stress and alters gene expression. High oxygen partial pressure during embryo development is associated with low pregnancy rates and increased embryonic apoptosis. We investigated how bovine embryos responded to high (20% O2 ) or low (5% O2 ) oxygen partial pressure during in vitro culture, evaluating levels of reactive oxygen species (ROS) as well as changes in the expression of oxidative stress- and epigenetic-related transcripts and miRNAs in blastocysts...
November 6, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29105880/cooperative-folding-of-linear-poly-dimethyl-siloxane-s-via-supramolecular-interactions
#8
Marcin L Ślęczkowski, Egbert W Meijer, Anja R A Palmans
The synthesis and characterization of graft copolymers are reported based on linear poly(dimethyl siloxane) (PDMS) and chiral, pendant benzene-1,3,5-tricarboxamides (BTAs). The copolymers differ in degree of polymerization (DP) and BTA graft density. Characterization of the bulk materials at room temperature reveals that the BTAs aggregate in a helical fashion via threefold hydrogen-bond formation within the PDMS matrix. A significant degree of hydrogen bonding persists up to 180 °C, regardless of DP and BTA content...
November 6, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29102833/touch-dna-sampling-with-scenesafe-fast%C3%A2-minitapes
#9
Britta Stoop, Priscille Merciani Defaux, Silvia Utz, Martin Zieger
To achieve optimal results in the forensic analysis of trace DNA, choosing the right collection technique is crucial. Three common approaches are currently well-established for DNA retrieval from items of clothing, notably cutting, swabbing and tape-lifting. The latter two are non-destructive and therefore preferable on items of value. Even though the most recently established technique of DNA retrieval by adhesive tapes is widely used since quite some years now, little information has been published so far on how well it performs compared to other methods...
October 27, 2017: Legal Medicine
https://www.readbyqxmd.com/read/29073274/transcriptome-analysis-of-mrna-and-micrornas-in-intramuscular-fat-tissues-of-castrated-and-intact-male-chinese-qinchuan-cattle
#10
Ying-Ying Zhang, Hong-Bao Wang, Ya-Ning Wang, Hong-Cheng Wang, Song Zhang, Jie-Yun Hong, Hong-Fang Guo, Dai Chen, Yang Yang, Lin-Sen Zan
Intramuscular fat (IMF) is known to enhance beef palatability and can be markedly increased by castration. However, there is little understanding of the molecular mechanism underlying the IMF deposition after castration of beef cattle. We hypothesize that genetic regulators function differently in IMF from bulls and steers. Therefore, after detecting serum testosterone and lipid parameter, as well as the contents of IMF at 6, 12, 18 and 24 months, we have investigated differentially expressed (DE) microRNAs (miRNAs) and mRNAs in IMF of bulls and steers at 24 months of age in Qinchuan cattle using next-generation sequencing, and then explored the possible biopathways regulating IMF deposition...
2017: PloS One
https://www.readbyqxmd.com/read/29063388/utilization-of-agents-to-prevent-skeletal-related-events-among-patients-with-multiple-myeloma-analysis-of-real-world-data
#11
Yi Qian, Debajyoti Bhowmik, Nandita Kachru, Rohini K Hernandez, Paul Cheng, Alexander Liede
PURPOSE: This study examined real-world utilization patterns of bone-targeted agents (BTA) in patients with multiple myeloma (MM). METHODS: In this retrospective cohort study, adults with an MM diagnosis recorded in 2012-2014 were identified from electronic health records in the Oncology Services Comprehensive Electronic Records (OSCER) database. Patients received zoledronic acid (ZA) or pamidronate (PA) on/after first MM diagnosis recorded in the study period, had no BTA use in prior 6 months, and were followed through earliest of May 31, 2015 or last clinic visit...
October 23, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29053134/-conversion-ratio-between-different-botulinum-neuroprotein-product-in-neurological-practice
#12
O R Orlova, S L Timerbaeva, S E Khatkova, E V Kostenko, D A Krasavina, D V Zakharov
Despite nearly 30 years of experience in the application of botulinum toxin type A (BTA) in clinical practice, many fundamental questions of therapy remain valid. There are 5 botulinum toxin type A used for neurological indications in the Russian Federation in 2017. They contain different number of active neuroprotein (150 kDa) in a therapeutic dose of the drug that may have a potential impact on the efficacy and duration of action. The current SmPC of each BTA stated that the unit of activity is unique and can not be compared with any other BTA...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29017490/germline-mutation-within-col2a1-associated-with-lethal-chondrodysplasia-in-a-polled-holstein-family
#13
Sina Reinartz, Hartmut Mohwinkel, Christian Sürie, Maren Hellige, Karsten Feige, Deborah Eikelberg, Andreas Beineke, Julia Metzger, Ottmar Distl
BACKGROUND: The bulldog calf syndrome is a lethal form of the inherited congenital chondrodysplasias. Among the progeny of the polled Holstein bull Energy P cases of lethal chondrodysplasia were observed. Pedigrees of the cases and the frequency of 3/8 cases among the offspring of Energy P at our teaching and experimental farm Ruthe (LuFG Ruthe) supported the assumption of a germline mutation with a mosaic of normal and defective sperm. RESULTS: All three malformed calves were examined using necropsy, histopathology and computed tomography scanning...
October 10, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28979232/beliefs-about-obedience-levels-in-studies-conducted-within-the-milgram-paradigm-better-than-average-effect-and-comparisons-of-typical-behaviors-by-residents-of-various-nations
#14
Tomasz Grzyb, Dariusz Dolinski
The article presents studies examining whether the better than average (BTA) effect appears in opinions regarding obedience of individuals participating in an experiment conducted in the Milgram paradigm. Participants are presented with a detailed description of the experiment, asked to declare at what moment an average participant would cease their participation in the study, and then asked to declare at what moment they themselves would quit the experiment. It turned out that the participants demonstrated a strong BTA effect...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28974708/embryological-evidence-substantiates-the-subcoxal-theory-on-the-origin-of-pleuron-in-insects
#15
Yuta Mashimo, Ryuichiro Machida
The lateral body plate pleuron is a significant structure in insects that contributes to the development and elaboration of wings and limbs (appendages). Although the pleuron is thought to originate from the proximal-most appendicular segment, the subcoxa, details remain unclear, and the morphological boundary between the dorsal body plate tergum and appendage (BTA) has not been clearly specified. Employing low-vacuum scanning electron microscopy (SEM) and the nano-suit method for SEM, we followed, in detail, the development of the thoracic segments of the two-spotted cricket Gryllus bimaculatus and succeeded in clearly defining the BTA...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28966069/biotimer-assay-a-reliable-and-rapid-method-for-the-evaluation-of-central-venous-catheter-microbial-colonization
#16
Luigi Rosa, Antimo Cutone, Monica Coletti, Maria Stefania Lepanto, Mellani Scotti, Piera Valenti, Giammarco Raponi, Maria Cristina Ghezzi, Francesca Berlutti
Adherent bacteria and biofilm frequently colonize central venous catheters (CVCs). CVC colonization is correlated to infections and particularly to bloodstream ones. The classical microbiological methods to determine of CVC colonization are not fully reliable and are time-consuming. BioTimer Assay (BTA) is a biological method already used to count bacteria adherent to abiotic surfaces and biofilm without sample manipulation. BTA employs specific reagents whose color changed according to bacterial metabolism...
September 29, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28957330/application-of-single-step-genomic-blup-under-different-uncertain-paternity-scenarios-using-simulated-data
#17
Rafael Lara Tonussi, Rafael Medeiros de Oliveira Silva, Ana Fabrícia Braga Magalhães, Rafael Espigolan, Elisa Peripolli, Bianca Ferreira Olivieri, Fabieli Loise Braga Feitosa, Marcos Vinicíus Antunes Lemos, Mariana Piatto Berton, Hermenegildo Lucas Justino Chiaia, Angelica Simone Cravo Pereira, Raysildo Barbosa Lôbo, Luiz Antônio Framartino Bezerra, Cláudio de Ulhoa Magnabosco, Daniela Andressa Lino Lourenço, Ignácio Aguilar, Fernando Baldi
The objective of this study was to investigate the application of BLUP and single step genomic BLUP (ssGBLUP) models in different scenarios of paternity uncertainty with different strategies of scaling the G matrix to match the A22 matrix, using simulated data for beef cattle. Genotypes, pedigree, and phenotypes for age at first calving (AFC) and weight at 550 days (W550) were simulated using heritabilities based on real data (0.12 for AFC and 0.34 for W550). Paternity uncertainty scenarios using 0, 25, 50, 75, and 100% of multiple sires (MS) were studied...
2017: PloS One
https://www.readbyqxmd.com/read/28922408/the-role-of-the-pi3k-akt-signaling-pathway-in-the-developmental-competence-of-bovine-oocytes
#18
Gabriella Mamede Andrade, Juliano Coelho da Silveira, Claudia Perrini, Maite Del Collado, Samuel Gebremedhn, Dawit Tesfaye, Flávio Vieira Meirelles, Felipe Perecin
The ovarian follicle encloses oocytes in a microenvironment throughout their growth and acquisition of competence. Evidence suggests a dynamic interplay among follicular cells and oocytes, since they are constantly exchanging "messages". We dissected bovine ovarian follicles and recovered follicular cells (FCs-granulosa and cumulus cells) and cumulus-oocyte complexes (COCs) to investigate whether the PI3K-Akt signaling pathway impacted oocyte quality. Following follicle rupture, COCs were individually selected for in vitro cultures to track the follicular cells based on oocyte competence to reach the blastocyst stage after parthenogenetic activation...
2017: PloS One
https://www.readbyqxmd.com/read/28903352/analysis-of-bos-taurus-and-sus-scrofa-x-and-y-chromosome-transcriptome-highlights-reproductive-driver-genes
#19
Faheem Ahmed Khan, Hui Liu, Hao Zhou, Kai Wang, Muhammad Tahir Ul Qamar, Nuruliarizki Shinta Pandupuspitasari, Zhang Shujun
The biology of sperm, its capability of fertilizing an egg and its role in sex ratio are the major biological questions in reproductive biology. To answer these question we integrated X and Y chromosome transcriptome across different species: Bos taurus and Sus scrofa and identified reproductive driver genes based on Weighted Gene Co-Expression Network Analysis (WGCNA) algorithm. Our strategy resulted in 11007 and 10445 unique genes consisting of 9 and 11 reproductive modules in Bos taurus and Sus scrofa, respectively...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28902440/real-time-control-of-the-enantioselectivity-of-a-supramolecular-catalyst-allows-selecting-the-configuration-of-consecutively-formed-stereogenic-centers
#20
Jeremy M Zimbron, Xavier Caumes, Yan Li, Christophe M Thomas, Matthieu Raynal, Laurent Bouteiller
The enantiomeric state of a supramolecular copper catalyst can be switched in situ in ca. five seconds. The dynamic property of the catalyst is provided by the non-covalent nature of the helical assemblies supporting the copper centers. These assemblies are formed by mixing an achiral benzene-1,3,5-tricarboxamide (BTA) phosphine ligand (for copper coordination) and both enantiomers of a chiral phosphine-free BTA co-monomer (for chirality amplification). The enantioselectivity of the hydrosilylation reaction is fixed by the BTA enantiomer in excess, which can be altered by simple BTA addition...
September 13, 2017: Angewandte Chemie
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