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https://www.readbyqxmd.com/read/28344384/ferroelectric-switching-and-electrochemistry-of-pyrrole-substituted-trialkylbenzene-1-3-5-tricarboxamides
#1
Xiao Meng, Andrey V Gorbunov, W S Christian Roelofs, Stefan C J Meskers, René A J Janssen, Martijn Kemerink, Rint P Sijbesma
We explore a new approach to organic ferroelectric diodes using a benzene-tricarboxamide (BTA) core connected with C10 alkyl chains to pyrrole groups, which can be polymerized to provide a semiconducting ferroelectric material. The compound possesses a columnar hexagonal liquid crystalline (LC) phase and exhibits ferroelectric switching. At low switching frequencies, an additional process occurs, which leads to a high hysteretic charge density of up to ∼1000 mC/m(2). Based on its slow rate, the formation of gas bubbles, and the emergence of characteristic polypyrrole absorption bands in the UV-Vis-NIR, the additional process is identified as the oxidative polymerization of pyrrole groups, enabled by the presence of amide groups...
April 1, 2017: Journal of Polymer Science. Part B, Polymer Physics
https://www.readbyqxmd.com/read/28335717/genomic-regions-underlying-susceptibility-to-bovine-tuberculosis-in-holstein-friesian-cattle
#2
Kethusegile Raphaka, Oswald Matika, Enrique Sánchez-Molano, Raphael Mrode, Mike Peter Coffey, Valentina Riggio, Elizabeth Janet Glass, John Arthur Woolliams, Stephen Christopher Bishop, Georgios Banos
BACKGROUND: The significant social and economic loss as a result of bovine tuberculosis (bTB) presents a continuous challenge to cattle industries in the UK and worldwide. However, host genetic variation in cattle susceptibility to bTB provides an opportunity to select for resistant animals and further understand the genetic mechanisms underlying disease dynamics. METHODS: The present study identified genomic regions associated with susceptibility to bTB using genome-wide association (GWA), regional heritability mapping (RHM) and chromosome association approaches...
March 23, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28315737/botulinum-toxin-as-an-adjunct-to-monocular-recession-resect%C3%A4-on-surgery-for-large-angle-sensory-strabismus
#3
Betül Tuğcu, Eda Sönmezay, Fadime Nuhoğlu, Hakan Özdemir, Seyhan Bahar Özkan
PURPOSE: To evaluate the result of using intraoperative botulinum toxin A (BTA) as an adjunct to monocular recession-resection surgery in the management of large-angle sensory strabismus. METHODS: The medical records of patients diagnosed with sensory strabismus with constant large-angle strabismus were reviewed retrospectively to identify those who underwent monocular recession-resection surgery combined with 5 units of BTA injection into the recessed muscle of the nonfixating eye...
March 15, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28301142/manganese-complex-of-ethylenediaminetetraacetic-acid-edta-benzothiazole-aniline-bta-conjugate-as-a-potential-liver-targeting-mri-contrast-agent
#4
Md Kamrul Islam, Soyeon Kim, Hee-Kyung Kim, Subin Park, Gang-Ho Lee, Hyo Jeung Kang, Jae-Chang Jung, Joon-Suk Park, Tae-Jeong Kim, Yongmin Chang
A novel manganese(II) complex based on an ethylenediaminetetraacetic acid (EDTA) coordination cage bearing a benzothiazole aniline (BTA) moiety (Mn-EDTA-BTA) was designed and synthesized for use as a liver-specific MRI contrast agent with high chelation stability. In addition to forming a hydrophilic, stable complex with Mn(2+), this new Mn chelate was rapidly taken up by liver hepatocytes and excreted by the kidneys and biliary system. The kinetic inertness and R1 relaxivity of the complex were much higher than those of mangafodipir trisodium (MnDPDP), a clinically approved liver-specific MRI contrast agent...
March 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28298201/the-patterns-of-genomic-variances-and-covariances-across-genome-for-milk-production-traits-between-chinese-and-nordic-holstein-populations
#5
Xiujin Li, Mogens Sandø Lund, Luc Janss, Chonglong Wang, Xiangdong Ding, Qin Zhang, Guosheng Su
BACKGROUND: With the development of SNP chips, SNP information provides an efficient approach to further disentangle different patterns of genomic variances and covariances across the genome for traits of interest. Due to the interaction between genotype and environment as well as possible differences in genetic background, it is reasonable to treat the performances of a biological trait in different populations as different but genetic correlated traits. In the present study, we performed an investigation on the patterns of region-specific genomic variances, covariances and correlations between Chinese and Nordic Holstein populations for three milk production traits...
March 15, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28294375/identification-of-the-interaction-between-bta-mir-370-and-olr1-gene-in-bovine-adipocyte
#6
H F Li, S H Wang, Y Guo, H B Zhao, X Y Li, X Wang
It has been shown that the oxidized low density lipoprotein receptor 1 (OLR1) gene plays an important role in the degradation of oxidized low density lipoprotein. Previous studies found a SNP in the 3'-untranslated region (3'-UTR) of the OLR1 gene associated with milk production traits in different dairy cattle populations and with loin eye area and marbling depth in beef cattle. MicroRNAs can regulate gene expression by binding the 3'-UTR of target genes to degrade or to repress the translation of target genes...
March 10, 2017: Animal Genetics
https://www.readbyqxmd.com/read/28288540/brainstem-vermis-and-brainstem-tentorium-angles-3d-ultrasound-study-of-the-intra-and-inter-observer-agreement
#7
Tamara Illescas, Pilar Martínez-Ten, Carmina Bermejo, María Estévez, Begoña Adiego
OBJECTIVE: The brainstem-vermis angle (BVA) and the brainstem-tentorium angle (BTA) have been proposed to quantify vermian and tentorial alterations associated to fetal posterior fossa malformations. Our objective is to evaluate the intra- and inter-observer agreement for the measurement of these angles during the prenatal ultrasound scan. METHODS: Fifteen 3D sets from fetuses with posterior fossa pathology were processed by multiplanar navigation. Four experts in prenatal ultrasound measured the BVA and the BTA on a mid-sagittal view of the fetal brain, following the criteria described by Volpe(1)...
March 13, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28272430/identification-and-characterization-of-differentially-expressed-mirnas-in-subcutaneous-adipose-between-wagyu-and-holstein-cattle
#8
Yuntao Guo, Xiuxiu Zhang, Wanlong Huang, Xiangyang Miao
MicroRNAs (miRNAs) are important post-transcriptional regulators involved in animal adipogenesis, however, their roles in bovine fat deposition remain poorly understood. In the present study, we conducted a comparative RNA sequencing to identify the key miRNAs involved in beef lipid accumulation by comparing the backfat small RNA samples between Wagyu (high intramuscular fat) and Holstein (moderate intramuscular fat) cattle. Fifteen miRNAs such as bta-miR-142-3p, bta-miR-379, bta-miR-196a, bta-miR-196b, bta-miR-30f and bta-miR-2887 were identified to have a higher expression level in Wagyu cattle compared with Holstein, whereas bta-miR-320a, bta-miR-874 and bta-miR-1247-3p had a lower expression level in Wagyu...
March 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28271231/quantitative-assessment-of-muscle-stiffness-with-acoustic-radiation-force-impulse-elastography-after-botulinum-toxin-a-injection-in-children-with-cerebral-palsy
#9
Meltem Ceyhan Bilgici, Tumay Bekci, Yasemin Ulus, Ayhan Bilgici, Leman Tomak, Mustafa Bekir Selcuk
PURPOSE: Our objective in this study was to assess the changes in medial gastrocnemius muscle (GCM) stiffness after botulinum toxin A (BTA) injection in children with cerebral palsy (CP) by using acoustic radiation force impulse (ARFI) elastography and to research the usability of this technique in clinical practice. MATERIALS AND METHODS: Twenty-four spastic lower extremities of 12 children with CP were assessed. BTA injection treatment was applied to the medial GCM...
March 7, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28270253/genomic-differentiation-between-asturiana-de-los-valles-avile%C3%A3-a-negra-ib%C3%A3-rica-bruna-dels-pirineus-morucha-pirenaica-retinta-and-rubia-gallega-cattle-breeds
#10
A González-Rodríguez, S Munilla, E F Mouresan, J J Cañas-Álvarez, J A Baro, A Molina, C Díaz, J Altarriba, J Piedrafita, L Varona
The Spanish local beef cattle breeds have most likely common origin followed by a process of differentiation. This particular historical evolution has most probably left detectable signatures in the genome. The objective of this study was to identify genomic regions associated with differentiation processes in seven Spanish autochthonous populations (Asturiana de los Valles (AV), Avileña-Negra Ibérica (ANI), Bruna dels Pirineus (BP), Morucha (Mo), Pirenaica (Pi), Retinta (Re) and Rubia Gallega (RG)). The BovineHD 777K BeadChip was used on 342 individuals (AV, n=50; ANI, n=48; BP, n=50; Mo, n=50; Pi, n=48; Re, n=48; RG, n=48) chosen to be as unrelated as possible...
March 8, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28255176/bta-mir-23a-involves-in-adipogenesis-of-progenitor-cells-derived-from-fetal-bovine-skeletal-muscle
#11
Long Guan, Xin Hu, Li Liu, Yishen Xing, Zhengkui Zhou, Xingwei Liang, Qiyuan Yang, Shengyun Jin, Jinshan Bao, Huijiang Gao, Min Du, Junya Li, Lupei Zhang
Intramuscular fat deposition or marbling is essential for high quality beef. The molecular mechanism of adipogenesis in skeletal muscle remains largely unknown. In this study, we isolated Platelet-derived growth factor receptor α (PDGFRα) positive progenitor cells from fetal bovine skeletal muscle and induced into adipocytes. Using miRNAome sequencing, we revealed that bta-miR-23a was an adipogenic miRNA mediating bovine adipogenesis in skeletal muscle. The expression of bta-miR-23a was down-regulated during differentiation of PDGFRα(+) progenitor cells...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28252359/an-across-breed-genome-wide-association-analysis-of-susceptibility-to-paratuberculosis-in-dairy-cattle
#12
Ahmed M Sallam, Yalda Zare, Fazli Alpay, George E Shook, Michael T Collins, Samir Alsheikh, Mahmoud Sharaby, Brian W Kirkpatrick
Paratuberculosis is a chronic disease of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). It occurs worldwide and causes a significant loss in the animal production industry. There is no cure for MAP infection and vaccination is problematic. Identification of genetics of susceptibility could be a useful adjunct for programs that focus on management, testing and culling of diseased animals. A case-control, genome-wide association study (GWAS) was conducted using Holstein and Jersey cattle in a combined analysis in order to identify markers and chromosomal regions associated with susceptibility to MAP infection across-breed...
February 2017: Journal of Dairy Research
https://www.readbyqxmd.com/read/28238365/the-well-sorted-fine-sand-community-from-the-western-mediterranean-sea-a-resistant-and-resilient-marine-habitat-under-diverse-human-pressures
#13
Jean-Claude Dauvin, Ali Bakalem, Alexandrine Baffreau, Claire Delecrin, Gérard Bellan, Claudio Lardicci, Elena Balestri, Rafael Sardá, Samir Grimes
The Biocoenosis of Well Sorted Fine Sands (WSFS) (SFBC, Sables Fins Bien Calibrés in French) is a Mediterranean community very well delimited by bathymetry (2-25 m) and sedimentology (>90% of fine sand) occurring in zones with relatively strong hydrodynamics. In this study focused on sites located along the Algerian, French, Italian and Spanish coasts of the Western Basin of the Mediterranean Sea (WBMS) we aim to compare the structure, ecological status and diversity of the macrofauna of the WSFS and examine the effects of recent human pressures on the state of this shallow macrobenthic community...
February 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28219476/genetic-parameters-and-genome-wide-associations-of-twinning-rate-in-a-local-breed-the-maremmana-cattle
#14
B Moioli, R Steri, C Marchitelli, G Catillo, L Buttazzoni
This study seeks to verify the feasibility of increasing twinning in a herd of the Italian autochtonous Maremmana breed. The data set included 1260 individuals born from 1963 to 2014, 527 males and 733 females, 402 of them calving at least once from 1983 through 2015. Breeding values for twinning were estimated by a single-trait linear animal model. However, since twinning is a dichotomous trait and the frequency of twins is far smaller than the frequency of single births, breeding values were also estimated by a single-trait animal threshold model...
February 21, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28212040/synthesis-and-speciation-dependent-properties-of-a-multimetallic-model-complex-of-nisod-that-exhibits-unique-hydrogen-bonding
#15
Ramsey A Steiner, Stephen P Dzul, Timothy L Stemmler, Todd C Harrop
The complex Na3[{Ni(II)(nmp)}3S3BTA(alk))] (1) (nmp(2-) = deprotonated form of N-(2-mercaptoethyl)picolinamide; H3S3BTA(alk) = N(1),N(3),N(5)-tris(2-mercaptoethyl)benzene-1,3,5-tricarboxamide, where H = dissociable protons), supported by the thiolate-benzenetricarboxamide scaffold (S3BTA(alk)), has been synthesized as a trimetallic model of nickel-containing superoxide dismutase (NiSOD). X-ray absorption spectroscopy (XAS) and (1)H NMR measurements on 1 indicate that the Ni(II) centers are square-planar with N2S2 coordination, and Ni-N and Ni-S distances of 1...
February 17, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28193175/genome-wide-association-mapping-for-milk-fat-composition-and-fine-mapping-of-a-qtl-for-de-novo-synthesis-of-milk-fatty-acids-on-bovine-chromosome-13
#16
Hanne Gro Olsen, Tim Martin Knutsen, Achim Kohler, Morten Svendsen, Lars Gidskehaug, Harald Grove, Torfinn Nome, Marte Sodeland, Kristil Kindem Sundsaasen, Matthew Peter Kent, Harald Martens, Sigbjørn Lien
BACKGROUND: Bovine milk is widely regarded as a nutritious food source for humans, although the effects of individual fatty acids on human health is a subject of debate. Based on the assumption that genomic selection offers potential to improve milk fat composition, there is strong interest to understand more about the genetic factors that influence the biosynthesis of bovine milk and the molecular mechanisms that regulate milk fat synthesis and secretion. For this reason, the work reported here aimed at identifying genetic variants that affect milk fatty acid composition in Norwegian Red cattle...
February 13, 2017: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/28164187/three-new-energetic-complexes-with-n-n-bis-1h-tetrazole-5-yl-amine-as-high-energy-density-materials-syntheses-structures-characterization-and-effects-on-the-thermal-decomposition-of-rdx
#17
Qi Yang, Xiaxia Song, Wendou Zhang, Lei Hou, Qibing Gong, Gang Xie, Qing Wei, Sanping Chen, Shengli Gao
Three new energetic complexes, [Pb(bta)(H2O)]n (1), [PbCu(bta)2(H2O)5]·2H2O (2) and PbCu(bta)2 (3) (H2bta = N,N-bis(1H-tetrazole-5-yl)-amine), have been synthesized and characterised. In particular, 3 was readily synthesized by dehydration of 2 at 190 °C. Single crystal X-ray diffraction revealed that 1 has a 3D framework structure and 2 presents a 3D supermolecular architecture. Thermoanalyses demonstrated that the main frames of 1 and 2 have good thermostabilities up to 314 °C for 1 and 231 °C for 2. Non-isothermal kinetic and thermodynamic parameters of exothermic decomposition processes of 1 and 2 were obtained by Kissinger's and Ozawa's methods...
February 6, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28155208/comparison-between-botulinum-toxin-a-injection-and-lacrimal-punctal-plugs-for-the-control-of-post-lasik-dry-eye-manifestations-a-prospective-study
#18
Sameh M Fouda, Hala K Mattout
INTRODUCTION: Laser in situ keratomelieusis (LASIK) is one of the commonest refractive procedures performed nowadays. The dry eye problem is nearly universal in all patients after LASIK and it can be so annoying that the post-operative patient satisfaction is sometimes precluded. Conventional treatment includes the use of artificial tears. Alternative methods such as punctal plugs and botulinum toxin injection can be used for the management of post-LASIK dry eye. The aim of this study is to compare botulinum toxin injection in the orbicularis muscle to lacrimal punctal plugs for the control of post-LASIK dry eye manifestations...
February 2, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28120114/longitudinal-patterns-of-bone-targeted-agent-use-among-patients-with-solid-tumors-and-bone-metastases-in-the-united-states
#19
Yi Qian, Debajyoti Bhowmik, Nandita Kachru, Rohini K Hernandez
PURPOSE: This study examined real-world long-term use of guideline-recommended bone targeted agents (BTA) among patients with metastatic solid tumors. METHODS: Adults with a solid tumor diagnosis followed by a bone metastasis diagnosis in 2012-2014 were identified from electronic medical records in the Oncology Services Comprehensive Electronic Records (OSCER) database. Patients initiated zoledronic acid (ZA) or denosumab on or after the bone metastasis diagnosis and were followed through last clinic visit by 30 June 2015...
January 24, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28115053/-patient-with-a-giant-umbilical-hernia-treated-preoperatively-with-botulinum-toxin-type-a
#20
Kristian Kiim Jensen, Margaret Hensler, Regnar Bøge Arnesen, Kenneth Jensen, Lars Nannestad Jørgensen
Surgical closure of giant abdominal wall hernia defects remains challenging. We report our initial experience with administration of botulinum toxin type A (BTA) for this approach in a 51-year-old female with a giant primary umbilical hernia and abdominal loss of domain. Four weeks prior to surgery, BTA was injected into the transverse abdominal and oblique muscles. During surgery the linea alba was reconstructed without lateral release procedures. At one-month follow-up, muscle relaxation had diminished and no surgical site occurrences were experienced...
January 23, 2017: Ugeskrift for Laeger
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