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https://www.readbyqxmd.com/read/27901138/understanding-the-self-assembly-of-amino-ester-based-benzene-1-3-5-tricarboxamides-using-molecular-dynamics-simulations
#1
Karteek K Bejagam, Richard C Remsing, Michael L Klein, Sundaram Balasubramanian
Amino ester-based benzene-1,3,5-tricarboxamides (BTAs) are widely studied experimentally for their facile self-assembly, which leads to strong three-fold hydrogen bonded supramolecular polymers. Understanding the supramolecular assembly of these BTAs is complicated by the presence of two types of dimers, based on the nature of the intermolecular hydrogen bonding pattern: amide-amide (AA) and amide-carboxylate (AC). AA dimers form three hydrogen bonds between the two molecules, are typical of BTA stacks, and act as a basic building block of assembly...
November 30, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27898967/genomewide-association-analysis-of-growth-traits-in-charolais-beef-cattle
#2
F J Jahuey-Martínez, G M Parra-Bracamonte, A M Sifuentes-Rincón, J C Martínez-González, C Gondro, C A García-Pérez, L A López-Bustamante
The objective of this study was to perform a genomewide association study (GWAS) for growth traits in Charolais beef cattle and to identify SNP markers and genes associated with these traits. Our study included 855 animals genotyped using 76,883 SNP from the GeneSeek Genomic Profiler Bovine HD panel. The examined phenotypic data included birth, weaning, and yearling weights as well as pre- and postweaning ADG. After quality control, 68,337 SNP and 823 animals were retained in the analysis. The association analysis was performed using the principal components method via the egscore function of the GenABEL version 1...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27889122/genome-wide-association-study-for-cheese-yield-and-curd-nutrient-recovery-in-dairy-cows
#3
C Dadousis, S Biffani, C Cipolat-Gotet, E L Nicolazzi, G J M Rosa, D Gianola, A Rossoni, E Santus, G Bittante, A Cecchinato
Cheese production and consumption are increasing in many countries worldwide. As a result, interest has increased in strategies for genetic selection of individuals for technological traits of milk related to cheese yield (CY) in dairy cattle breeding. However, little is known about the genetic background of a cow's ability to produce cheese. Recently, a relatively large panel (1,264 cows) of different measures of individual cow CY and milk nutrient and energy recoveries in the cheese (REC) became available...
November 23, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27884065/the-efficacy-of-2-formulations-of-botulinum-toxin-type-a-for-masseter-reduction-a-split-face-comparison-study
#4
Rungsima Wanitphakdeedecha, Chanida Ungaksornpairote, Arisa Kaewkes, Angkana Sathaworawong, Nittaya Lektrakul, Woraphong Manuskiatti
BACKGROUND: Botulinum toxin type A (BTA) is now extensively used to address cosmetic concerns. OnabotulinumtoxinA (ONA, Botox; Allergan Inc., Irvine, CA) received FDA approval for upper face rejuvenation, including glabella frown lines and crow's-feet lines. The other off-label uses for lower face conditions have been utilized for contouring purposes, especially masseter hypertrophy. Recently, a new Daewoong BTA, (Nabota, NBT, Daewoong Pharmaceutical, Seoul, Korea), was recently introduced...
November 25, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27873169/evaluation-for-the-efficacy-and-safety-of-the-crosser-catheter-as-a-cto-crossing-device-and-a-flossing-device
#5
Michinao Tan, Kazushi Urasawa, Ryoji Koshida, Takuya Haraguchi, Shunsuke Kitani, Yuya Nakagawa, Yasumi Igarashi, Katsuhiko Sato
The Crosser catheter is a unique device that facilitates antegrade intraluminal recanalization by high-frequency vibration energy and cavitation. We used this device not only as a chronic total occlusion (CTO) crossing device, but also as a flossing device in stenotic lesions and we also evaluated the efficacy of this device when used with both the "Crosser preceding" and the "Guidewire preceding" in CTOs. Complications related to this device were investigated, too. We retrospectively analyzed a total of 90 consecutive patients with peripheral artery disease in the femoropopliteal artery and below-the-knee artery (BTA)...
November 21, 2016: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/27808386/identification-of-snps-located-on-bta-6-and-bta-20-significantly-associated-with-bovine-respiratory-disease-in-crossbred-cattle
#6
S L Miller, S Mizell, R Walker, T Page, M D Garcia
The objective of the present study was to evaluate single nucleotide polymorphisms (SNPs) located in two quantitative trait locus (QTL) regions (BTA 6 and BTA 20) that are associated with bovine respiratory disease (BRD). A population of 323 crossbred steers sired by five purebred sire breeds during 2010-2013 (Angus, Braford, Braunvieh, Charolais, and Simmental) were evaluated for BRD susceptibility during the finishing process at a commercial feedlot. A total of 21 animals representing all sire breeds were affected with BRD at some time during the finishing process over the 4-year period...
October 6, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27785504/tuning-the-structure-of-1-3-5-benzene-tricarboxamide-self-assemblies-through-stereochemistry
#7
Xavier Caumes, Arianna Baldi, Geoffrey Gontard, Patrick Brocorens, Roberto Lazzaroni, Nicolas Vanthuyne, Claire Troufflard, Matthieu Raynal, Laurent Bouteiller
A heterochiral 1,3,5-benzene tricarboxamide (BTA) monomer, derived from valine dodecyl ester, forms long rods in cyclohexane whilst its homochiral analogue assembles into dimers only at the same concentration. This highly original assembly behaviour is related to the destabilization of the dimeric structure containing the two heterochiral monomers as corroborated by a combined experimental and computational study.
October 27, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27782297/botulinum-toxin-type-a-versus-botulinum-toxin-type-b-for-cervical-dystonia
#8
REVIEW
Gonçalo S Duarte, Mafalda Castelão, Filipe B Rodrigues, Raquel E Marques, Joaquim Ferreira, Cristina Sampaio, Austen P Moore, João Costa
BACKGROUND: This is an update of a Cochrane review first published in 2003. Cervical dystonia is the most common form of focal dystonia and is a disabling disorder characterised by painful involuntary head posturing. There are two available formulations of botulinum toxin, with botulinum toxin type A (BtA) usually considered the first line therapy for this condition. Botulinum toxin type B (BtB) is an alternative option, with no compelling theoretical reason why it might not be as- or even more effective - than BtA...
October 26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27776857/adsorption-of-benzotriazole-and-benzimidazole-from-water-over-a-co-based-metal-azolate-framework-maf-5-co
#9
Mithun Sarker, Biswa Nath Bhadra, Pill Won Seo, Sung Hwa Jhung
Benzotriazole (BTA) and benzimidazole (BZI) are regarded as water pollutants because of their extensive uses in industry and appreciable water solubility. The adsorption of both BTA and BZI from water over a newly synthesized metal-organic framework, MAF-5(Co), was investigated and compared with zeolitic imidazole frameworks (ZIFs), such as ZIF-8(Zn) and ZIF-67(Co), as well as commercial activated carbon. MAF-5(Co) had the highest adsorption capacities for both BTA and BZI. The maximum adsorption capacities of MAF-5(Co) for BTA and BZI were 389 and 175mgg(-1), respectively...
October 19, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27766427/roles-of-bta-mir-29b-promoter-regions-dna-methylation-in-regulating-mir-29b-expression-and-bovine-viral-diarrhea-virus-nadl-replication-in-mdbk-cells
#10
Qiang Fu, Huijun Shi, Chuangfu Chen
MicroRNAs (miRNAs) are an important class of small, non-coding RNAs that control target genes expression by degradation of target mRNAs or by inhibiting protein translation in many biological processes and cellular pathways. In a previous study, we found that miR-29b interfered with bovine viral diarrhea virus (BVDV) replication. However, the mechanisms of regulation of miR-29b expression are not well known. DNA methylation is an important epigenetic mechanism for silencing gene transcription, and plays an important role in promoter choice, protein expression, and regulation of miRNAs expression...
October 20, 2016: Archives of Virology
https://www.readbyqxmd.com/read/27722677/tuning-the-nature-and-stability-of-self-assemblies-formed-by-ester-benzene-1-3-5-tricarboxamides-the-crucial-role-played-by-the-substituents
#11
Alaric Desmarchelier, Bruno Giordano Alvarenga, Xavier Caumes, Ludovic Dubreucq, Claire Troufflard, Martine Tessier, Nicolas Vanthuyne, Julien Idé, Thomas Maistriaux, David Beljonne, Patrick Brocorens, Roberto Lazzaroni, Matthieu Raynal, Laurent Bouteiller
As the benzene 1,3,5-tricarboxamide (BTA) moiety is commonly used as the central assembling unit for the construction of functionalized supramolecular architectures, strategies to tailor the nature and stability of BTA assemblies are needed. The assembly properties of a library of structurally simple BTAs derived from amino dodecyl esters (ester BTAs, 13 members) have been studied, either in the bulk or in cyclohexane solutions, by means of a series of analytical methods (NMR, DSC, POM, FT-IR, UV-Vis, CD, ITC, high-sensitivity DSC, SANS)...
September 20, 2016: Soft Matter
https://www.readbyqxmd.com/read/27722553/distinction-of-trans-cis-photoisomers-with-comparable-optical-properties-in-multiple-state-photochromic-systems-examining-a-molecule-with-three-azobenzenes-via-in-situ-irradiation-nmr-spectroscopy
#12
Jonas Kind, Lukas Kaltschnee, Martin Leyendecker, Christina M Thiele
Photochromic compounds like azobenzenes are widely used for the production of stimuli responsive materials. To analyse cascaded azobenzene switching inside a benzene-tricarboxamide (BTA) with three azobenzene moieties in a site-specific fashion, we used in situ irradiation NMR spectroscopy. Four photoisomers can be distinguished by their chemical shifts. Analysis of (1)H, (13)C and (15)N shifts reveals that the configuration of one sidechain has an influence on the chemical shifts of both the other sidechains...
October 13, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27714814/genetic-identification-of-communist-crimes-victims-1944-1956-based-on-the-analysis-of-one-of-many-mass-graves-discovered-on-the-powazki-military-cemetery-in-warsaw-poland
#13
Andrzej Ossowski, Marta Diepenbroek, Tomasz Kupiec, Milena Bykowska-Witowska, Grażyna Zielińska, Teresa Dembińska, Andrzej Ciechanowicz
As the result of the communist terror in Poland, during years 1944-1956 more than 50,000 people died. Their bodies were buried secretly, and most places are still unknown. The research presents the results of identification of people buried in one of many mass graves, which were found at the cemetery Powązki Military in Warsaw, Poland. Exhumation revealed the remains of eight people, among which seven were identified genetically. Well-preserved molars were used for the study. Reference material was collected from the closest living relatives...
November 2016: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/27708120/commercial-dairy-cow-milk-micrornas-resist-digestion-under-simulated-gastrointestinal-tract-conditions
#14
Abderrahim Benmoussa, Chan Ho C Lee, Benoit Laffont, Patricia Savard, Jonathan Laugier, Eric Boilard, Caroline Gilbert, Ismail Fliss, Patrick Provost
BACKGROUND: MicroRNAs are small, gene-regulatory noncoding RNA species present in large amounts in milk, where they seem to be protected against degradative conditions, presumably because of their association with exosomes. OBJECTIVE: We monitored the relative stability of commercial dairy cow milk microRNAs during digestion and examined their associations with extracellular vesicles (EVs). METHODS: We used a computer-controlled, in vitro, gastrointestinal model TNO intestinal model-1 (TIM-1) and analyzed, by quantitative polymerase chain reaction, the concentration of 2 microRNAs within gastrointestinal tract compartments at different points in time...
November 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27696932/improving-diagnostic-molecular-tests-to-monitor-urothelial-carcinoma-recurrence
#15
Laura-Maria Krabbe, Solomon L Woldu, Shahrokh F Shariat, Yair Lotan
The high recurrence rates associated with non-muscle invasive bladder cancer require close surveillance with cystoscopy, an invasive and expensive procedure with risk of missing cancer. Finding an accurate urinary biomarker that can detect recurrent disease would represent a significant advancement in management. Areas covered: This review summarizes the commercially-available urinary biomarkers including cytology, UroVysion, BTA, NMP22, uCyt+, and Cxbladder assays. Additionally, we review recent investigational urinary biomarkers that hold promise in bladder cancer surveillance...
November 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27696835/effect-of-h-bonding-on-order-amplification-in-the-growth-of-a-supramolecular-polymer-in-water
#16
Matteo Garzoni, Matthew B Baker, Christianus M A Leenders, Ilja K Voets, Lorenzo Albertazzi, Anja R A Palmans, Egbert Willem Meijer, Giovanni M Pavan
While a great deal of knowledge on the roles of hydrogen bonding and hydrophobicity in proteins have resulted in the creation of rationally designed and functional peptidic structures, the roles of these forces on purely synthetic supramolecular architectures in water have proven difficult to ascertain. Focusing on a 1,3,5-benzenetricarboxamide (BTA) based supramolecular polymer, we have designed a molecular modeling strategy to dissect the energetic contributions involved in the self-assembly (electrostatic, hydrophobic, etc...
October 4, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27693181/amyloid-tracers-binding-sites-in-autosomal-dominant-and-sporadic-alzheimer-s-disease
#17
Ruiqing Ni, Per-Göran Gillberg, Nenad Bogdanovic, Matti Viitanen, Liisa Myllykangas, Inger Nennesmo, Bengt Långström, Agneta Nordberg
INTRODUCTION: Amyloid imaging has been integrated into diagnostic criteria for Alzheimer's disease (AD). How amyloid tracers binding differ for different tracer structure and amyloid-β aggregate in autosomal dominant AD (ADAD) and sporadic AD is unclear. METHODS: Binding properties of different amyloid tracers were examined in brain homogenates from six ADAD with APPswe, PS1 M146V, and PS1 EΔ9 mutations, 13 sporadic AD, and 14 control cases. RESULTS: (3)H-PIB, (3)H-florbetaben, (3)H-AZD2184, and BTA-1 shared a high- and a varying low-affinity binding site in the frontal cortex of sporadic AD...
September 28, 2016: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/27669152/functional-snps-of-incenp-affect-semen-quality-by-alternative-splicing-mode-and-binding-affinity-with-the-target-bta-mir-378-in-chinese-holstein-bulls
#18
Juan Liu, Yan Sun, Chunhong Yang, Yan Zhang, Qiang Jiang, Jinming Huang, Zhihua Ju, Xiuge Wang, Jifeng Zhong, Changfa Wang
Inner centromere protein (INCENP) plays an important role in mitosis and meiosis as the main member of chromosomal passenger protein complex (CPC). To investigate the functional markers of the INCENP gene associated with semen quality, the single nucleotide polymorphisms (SNPs) g.19970 A>G and g.34078 T>G were identified and analyzed. The new splice variant INCENP-TV is characterized by the deletion of exon 12. The g.19970 A>G in the exonic splicing enhancer (ESE) motif region results in an aberrant splice variant by constructing two minigene expression vectors using the pSPL3 exon capturing vector and transfecting vectors into MLTC-1 cells...
2016: PloS One
https://www.readbyqxmd.com/read/27647769/the-comparison-between-intradermal-injection-of-abobotulinumtoxina-and-normal-saline-for-face-lifting-a-split-face-randomized-controlled-trial
#19
Rungsima Wanitphakdeedecha, Chanida Ungaksornpairote, Arisa Kaewkes, Viboon Rojanavanich, Weeranut Phothong, Woraphong Manuskiatti
BACKGROUND: Botulinum toxin type A (BTA) has been approved for the treatment of strabismus, blepharospasm, muscle spasm, cervical dystonia, pain syndrome, glabella wrinkles, and severe primary axillary hyperhidrosis. Intradermal injection of BTA has been used off-label by many clinicians for the purpose of face-lifting effect. Few studies on onabotulinumtoxinA (ONA) demonstrated no clinical efficacy on face-lifting effect when comparing to normal saline solution (NSS). So far, there is no split-face comparison study on face-lifting effect of abobotulinumtoxinA (ABO)...
September 19, 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27635608/-the-efficacy-of-botulinum-toxin-therapy-in-patients-with-upper-limb-spasticity-due-to-traumatic-brain-injury
#20
M A Akulov, S E Khat'kova, O A Mokienko, O R Orlova, D Yu Usachev, V O Zakharov, A S Orlova, A A Tomsky
Spasticity is a type of muscle hyperactivity that occurs in patients after focal lesions of the Central nervous system due to various diseases: stroke, traumatic brain injury or spinal cord injury, neurosurgical intervention, as well as multiple sclerosis and other diseases of the Central nervous system and is the most disability manifestation of the syndrome of upper motor neuron (UMNS). Focal spasticity of the upper limb requires a complex treatment. Botulinum toxin therapy is an effective treatment for focal/multifocal spasticity in reducing muscle tone and improving function with the highest level of evidence according to the latest American and European guidelines for treatment of spasticity...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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