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https://www.readbyqxmd.com/read/28548557/further-examination-of-embedded-performance-validity-indicators-for-the-conners-continuous-performance-test-and-brief-test-of-attention-in-a-large-outpatient-clinical-sample
#1
Michael J Sharland, Stephen C Waring, Brian P Johnson, Allise M Taran, Travis A Rusin, Andrew M Pattock, Jeanette A Palcher
OBJECTIVE: Assessing test performance validity is a standard clinical practice and although studies have examined the utility of cognitive/memory measures, few have examined attention measures as indicators of performance validity beyond the Reliable Digit Span. The current study further investigates the classification probability of embedded Performance Validity Tests (PVTs) within the Brief Test of Attention (BTA) and the Conners' Continuous Performance Test (CPT-II), in a large clinical sample...
May 26, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28514309/a-randomized-controlled-trial-of-botulinum-toxin-a-for-treating-neuropathic-pain-in-patients-with-spinal-cord-injury
#2
Gang Li, Chang-An Lv, Li Tian, Lian-Jin Jin, Ping Sun, Wei Zhao
BACKGROUND: To assess the effect of botulinum toxin A (BTA) for treating neuropathic pain in patients with spinal cord injury (SCI). METHODS: A total of 44 patients with SCI with neuropathic pain were randomly divided into the intervention group and the placebo group, each group 21 patients. The subjects in the intervention group received BTA (200 U subcutaneous injection, once daily) at the painful area, whereas those in the placebo group were administered a saline placebo...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28504253/dynamic-diversity-of-synthetic-supramolecular-polymers-in-water-as-revealed-by-hydrogen-deuterium-exchange
#3
Xianwen Lou, René P M Lafleur, Christianus M A Leenders, Sandra M C Schoenmakers, Nicholas M Matsumoto, Matthew B Baker, Joost L J van Dongen, Anja R A Palmans, E W Meijer
Numerous self-assembling molecules have been synthesized aiming at mimicking both the structural and dynamic properties found in living systems. Here we show the application of hydrogen/deuterium exchange (HDX) mass spectrometry (MS) to unravel the nanoscale organization and the structural dynamics of synthetic supramolecular polymers in water. We select benzene-1,3,5-tricarboxamide (BTA) derivatives that self-assemble in H2O to illustrate the strength of this technique for supramolecular polymers. The BTA structure has six exchangeable hydrogen atoms and we follow their exchange as a function of time after diluting the H2O solution with a 100-fold excess of D2O...
May 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28497442/-myths-and-evidence-on-the-use-of-botulinum-toxin-spasticity-in-adults-and-in-children-with-cerebral-palsy
#4
J C Martinez-Castrillo, J L Pena-Segura, P Sanz-Cartagena, X Alonso-Curco, J M Arbelo-Gonzalez, G Arriola-Pereda, M D Coll-Bosch, J A Conejero-Casares, A Garcia-Ribes, S Jauma-Classen, J Pagonabarraga, J Vidal-Valls, P J Garcia-Ruiz
INTRODUCTION: Spasticity is a medical problem with a high incidence that significantly impact on the quality of life of patients and their families. AIM: To analyze and to answer different questions about the use of botulinum toxin type A (BTA) in our clinical practice. DEVELOPMENT: A group of experts in neurology develop a list of topics related with the use of BTA. Two big groups were considered: spasticity in adults and in children with cerebral palsy...
May 16, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28494404/treatment-and-pattern-of-bone-metastases-in-1094-patients-with-advanced-breast-cancer-results-from-the-prospective-german-tumour-registry-breast-cancer-cohort-study
#5
Jan Schröder, Thomas Fietz, Andreas Köhler, Volker Petersen, Hans Tesch, Lisa Spring, Annette Fleitz, Martina Jänicke, Norbert Marschner
A high proportion of patients with breast cancer develop bone metastases, yet data on routine treatment with bone-targeted agents (BTA) are rare. We report real-life outcome data of patients with breast cancer metastasised to the bone treated by office-based oncologists in Germany. The ongoing, prospective, multicentre, population-based cohort study Tumour Registry Breast Cancer (TMK) was started in 2007 in 140 centres across Germany. This interim analysis of 1094 patients with bone metastases revealed differences among the tumour subtypes: at start of first-line therapy, 36% of the patients with hormone receptor (HR)-positive and only 20% of the patients with HR-negative tumours presented with bone-only metastasis...
May 8, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28485145/supramolecular-copolymers-structure-and-composition-revealed-by-theoretical-modeling
#6
Anindita Das, Ghislaine Vantomme, Albert J Markvoort, Huub M M Ten Eikelder, Miguel Garcia-Iglesias, Anja R A Palmans, E W Meijer
Supramolecular copolymers, non-covalent analogues of synthetic copolymers, constitute a new and promising class of polymers. In contrast to their covalent counterparts, the details of their mechanism of formation, as well as the factors determining their composition and length, are still poorly understood. Here, the supramolecular copolymerization between two slightly structurally different benzene-1,3,5-tricarboxamide (BTA) monomers functionalized with either oligodimethylsiloxane (oDMSi) or alkyl side chains is unraveled by combining experimental and theoretical approaches...
May 16, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28467969/analysis-of-bos-taurus-and-sus-scrofa-x-and-y-chromosome-transcriptome-highlights-reproductive-driver-genes
#7
Faheem Ahmed Khan, Hui Liu, Hao Zhou, Kai Wang, Muhammad Tahir Ul Qamar, Nuruliarizki Shinta Pandupuspitasari, Zhang Shujun
The biology of sperm, its capability of fertilizing an egg and its role in sex ratio are the major biological questions in reproductive biology. To answer these question we integrated X and Y chromosome transcriptome across different species: Bos taurus and Sus scrofa and identified reproductive driver genes based on Weighted Gene Co-Expression Network Analysis (WGCNA) algorithm. Our strategy resulted in 11007 and 10445 unique genes consisting of 9 and 11 reproductive modules in Bos taurus and Sus scrofa, respectively...
April 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28467708/novel-benzothiazole-derivatives-as-fluorescent-probes-for-detection-of-%C3%AE-amyloid-and-%C3%AE-synuclein-aggregates
#8
Hiroyuki Watanabe, Masahiro Ono, Taisuke Ariyoshi, Rikako Katayanagi, Hideo Saji
Deposits of β-amyloid (Aβ) and α-synuclein (α-syn) are the hallmark of Alzheimer's disease (AD) and Parkinson's disease (PD), respectively. The detection of these protein aggregates with fluorescent probes is particularly of interest for preclinical studies using fluorescence microscopy on human brain tissue. In this study, we newly designed and synthesized three push-pull benzothiazole (PP-BTA) derivatives as fluorescent probes for detection of Aβ and α-syn aggregates. Fluorescence intensity of all PP-BTA derivatives significantly increased upon binding to Aβ(1-42) and α-syn aggregates in solution...
May 3, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28464792/detection-and-comparison-of-micrornas-in-the-caprine-mammary-gland-tissues-of-colostrum-and-common-milk-stages
#9
Jinxing Hou, Xiaopeng An, Yuxuan Song, Binyun Cao, Heping Yang, Zhou Zhang, Wenzheng Shen, Yunpu Li
BACKGROUND: MicroRNAs (miRNAs) have a great influence on various physiological functions. A lot of high-throughput sequencing (HTS) research on miRNAs has been executed in the caprine mammary gland at different lactation periods (common milk lactation and dry period), but little is known about differentially expressed miRNAs in the caprine mammary gland of colostrum and peak lactation periods. RESULT: This study identified 131 differentially expressed miRNAs (P < 0...
May 2, 2017: BMC Genetics
https://www.readbyqxmd.com/read/28464084/genomic-prediction-and-genome-wide-association-analysis-of-female-longevity-in-a-composite-beef-cattle-breed
#10
E Hamidi Hay, A Roberts
Longevity is a highly important trait to the efficiency of beef cattle production. The objective of this study was to evaluate the genomic prediction of longevity and identify genomic regions associated with this trait. The data used in this study consisted of 547 Composite Gene Combination cows (1/2 Red Angus, 1/4 Charolais, 1/4 Tarentaise) born from 2002 to 2011 genotyped with Illumina BovineSNP50 BeadChip. Three models were used to assess genomic prediction: Bayes A, Bayes B and GBLUP using a genomic relationship matrix...
April 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28460047/impact-of-the-ability-to-divide-attention-on-reading-performance-in-glaucoma
#11
Bonnielin K Swenor, Varshini Varadaraj, Paulomi Dave, Sheila K West, Gary S Rubin, Pradeep Y Ramulu
Purpose: To determine if the ability to divide attention affects the relationship between glaucoma-related vision loss and reading speed. Methods: Better eye mean deviation (MD), contrast sensitivity (CS), and better-eye distance visual acuity (VA) were measured in 28 participants with glaucoma and 21 controls. Reading speeds were assessed using MNRead, IRest, and sustained silent reading tests (words per minute, wpm). The ability to divide attention was measured using the Brief Test of Attention (BTA; scored 0-10)...
May 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28440381/lyotropic-meso-phase-behavior-of-supra-molecular-nanotubes-with-helical-charge-distribution
#12
Shenghui Wei, Weiheng Huang, Fengmei Su, Xiaoliang Tang, Ningdong Huang, Liangbin Li
We report diverse meso-phase arrangements of supra-molecular nanotubes assembled by ionic benzene-1,3,5-tricarboxamide (BTA) molecules in water; their transition pathway and equilibrium structure are controlled by the helical structure. Besides, the different sensitivity to the condition of initial solutions is revealed for the final rectangular phase and the intermediate phase.
April 25, 2017: Soft Matter
https://www.readbyqxmd.com/read/28434389/evaluation-of-the-protective-effect-of-botulinum-toxin-type-a-injection-on-otitis-media-with-effusion
#13
Ömer Faruk Çalım, Yavuz Selim Yıldırım, Remzi Doğan, Selhattin Tuğrul, Özge Gedik, Orhan Özturan
OBJECTIVE: This study makes an analysis of the effect of Botulinum toxin type A on otitis media with effusion in rats. METHOD: As part of the study, 24 male Wistar Albino rats were divided into three groups: Group 1: Botulinum toxin Type A and Histamıne (intratympanic 0.2 ml = 20 unit BTA); Group 2: Saline and Histamine (intratympanic 0.2 ml 0.9%); Group 3: Histamine (intratympanic 0.2 ml). Histamine (intratympanic 0.2 ml) was administered into the right ear for all groups...
April 22, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28431196/switch-to-abobotulinum-toxin-a-may-be-useful-in-the-treatment-of-neurogenic-detrusor-overactivity-when-intradetrusor-injections-of-onabotulinum-toxin-a-failed
#14
Florie Bottet, Benoit Peyronnet, Romain Boissier, Bénédicte Reiss, Jean G Previnaire, Andrea Manunta, Jacques Kerdraon, Alain Ruffion, Loïc Lenormand, Brigitte Perrouin Verbe, Sarah Gaillet, Xavier Gamé, Gilles Karsenty
AIMS: To assess the outcomes of switching to a different brand of botulinum toxin A (BTA, from Botox® to Dysport®) in case of failure of intradetrusor injections (IDI) of Botox® in the treatment of neurogenic detrusor overactivity (NDO). METHODS: The charts of all patients who underwent a switch to IDI of Dysport® after failure of an IDI of Botox® at six departments of neurourology were retrospectively reviewed. The main outcomes of interest were the bladder diary data and four urodynamic parameters: maximum cystometric capacity (MCC), maximum detrusor pressure (PDET max), and volume at first uninhibited detrusor contraction (UDC)...
April 21, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28396943/sonographic-differences-between-conventional-and-follicular-variant-papillary-thyroid-carcinoma
#15
Nicola M Hughes, Andreea Nae, Josephine Barry, Brendan Fitzgerald, Linda Feeley, Patrick Sheahan
Follicular variant papillary thyroid carcinoma (FVPTC) may pose a diagnostic challenge due to higher likelihood of lower risk cytology compared to conventional papillary thyroid carcinoma (CPTC). Recent guidelines have recommended the use of sonographic features to guide decisions to biopsy thyroid nodules. The purpose of this study was to evaluate the sonographic features of CPTC and FVPTC. This is a retrospective study design done in an Academic teaching hospital setting. Preoperative ultrasounds of 79 patients with conventional CPTC (48) and FVPTC (31) were reviewed by a radiologist blinded to histological diagnosis...
April 10, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28388926/proof-of-concept-study-profile-of-circulating-micrornas-in-bovine-serum-harvested-during-acute-and-persistent-fmdv-infection
#16
Carolina Stenfeldt, Jonathan Arzt, George Smoliga, Michael LaRocco, Joseph Gutkoska, Paul Lawrence
BACKGROUND: Changes in the levels of circulating microRNAs (miRNAs) in the serum of humans and animals have been detected as a result of infection with a variety of viruses. However, to date, such a miRNA profiling study has not been conducted for foot-and-mouth disease virus (FMDV) infection. METHODS: The relative abundance of 169 miRNAs was measured in bovine serum collected at three different phases of FMDV infection in a proof-of-concept study using miRNA PCR array plates...
April 7, 2017: Virology Journal
https://www.readbyqxmd.com/read/28380033/antagonistic-genetic-correlations-for-milking-traits-within-the-genome-of-dairy-cattle
#17
Olivier Gervais, Ricardo Pong-Wong, Pau Navarro, Chris S Haley, Yoshitaka Nagamine
Genome-wide association studies can be applied to identify useful SNPs associated with complex traits. Furthermore, regional genomic mapping can be used to estimate regional variance and clarify the genomic relationships within and outside regions but has not previously been applied to milk traits in cattle. We applied both single SNP analysis and regional genomic mapping to investigate SNPs or regions associated with milk yield traits in dairy cattle. The de-regressed breeding values of three traits, total yield (kg) of milk (MLK), fat (FAT), and protein (PRT) in 305 days, from 2,590 Holstein sires in Japan were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28364265/molecular-characterization-and-snp-identification-in-hspb6-gene-in-karan-fries-bos-taurus-x-bos-indicus-cattle
#18
Rakesh Kumar, I D Gupta, Archana Verma, Ragini Kumari, Nishant Verma
Heat shock proteins (HSPs) act as molecular chaperones which are preferentially transcribed in response to severe perturbations of the cellular homeostasis such as heat stress. The present study was undertaken for molecular characterization and detection of genetic polymorphisms of HSPB6 gene in 100 Karan Fries Cattle. HSPB6 gene was mapped on Bos taurus autosome 18 (BTA 18), comprising three exons and two introns. Four sets of primers for HSPB6 gene were designed using Primer3 software (version 0.4.0). For detecting single nucleotide polymorphisms (SNPs), sequence data was analyzed using BioEdit software (version 7...
March 31, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28344384/ferroelectric-switching-and-electrochemistry-of-pyrrole-substituted-trialkylbenzene-1-3-5-tricarboxamides
#19
Xiao Meng, Andrey V Gorbunov, W S Christian Roelofs, Stefan C J Meskers, René A J Janssen, Martijn Kemerink, Rint P Sijbesma
We explore a new approach to organic ferroelectric diodes using a benzene-tricarboxamide (BTA) core connected with C10 alkyl chains to pyrrole groups, which can be polymerized to provide a semiconducting ferroelectric material. The compound possesses a columnar hexagonal liquid crystalline (LC) phase and exhibits ferroelectric switching. At low switching frequencies, an additional process occurs, which leads to a high hysteretic charge density of up to ∼1000 mC/m(2). Based on its slow rate, the formation of gas bubbles, and the emergence of characteristic polypyrrole absorption bands in the UV-Vis-NIR, the additional process is identified as the oxidative polymerization of pyrrole groups, enabled by the presence of amide groups...
April 1, 2017: Journal of Polymer Science. Part B, Polymer Physics
https://www.readbyqxmd.com/read/28335717/genomic-regions-underlying-susceptibility-to-bovine-tuberculosis-in-holstein-friesian-cattle
#20
Kethusegile Raphaka, Oswald Matika, Enrique Sánchez-Molano, Raphael Mrode, Mike Peter Coffey, Valentina Riggio, Elizabeth Janet Glass, John Arthur Woolliams, Stephen Christopher Bishop, Georgios Banos
BACKGROUND: The significant social and economic loss as a result of bovine tuberculosis (bTB) presents a continuous challenge to cattle industries in the UK and worldwide. However, host genetic variation in cattle susceptibility to bTB provides an opportunity to select for resistant animals and further understand the genetic mechanisms underlying disease dynamics. METHODS: The present study identified genomic regions associated with susceptibility to bTB using genome-wide association (GWA), regional heritability mapping (RHM) and chromosome association approaches...
March 23, 2017: BMC Genetics
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