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https://www.readbyqxmd.com/read/29145233/prospective-evaluation-of-the-feasibility-safety-and-efficacy-of-cocoon-duct-occluder-for-transcatheter-closure-of-large-patent-ductus-arteriosus-a-single-center-study-with-short-and-medium-term-follow-up-results
#1
Santosh Kumar Sinha, Mahmadula Razi, Rama Niwas Pandey, Prakash Kumar, Vinay Krishna, Mukesh Jitendra Jha, Vikas Mishra, Mohammad Asif, Nasar Abdali, Pradyot Tewari, Ramesh Thakur, Umeshwar Pandey, Chandra Mohan Varma
OBJECTIVE: To evaluate the feasibility, safety, and efficacy of a novel Cocoon Duct Occluder device for the transcatheter closure (TCC) of large patent ductus arteriosus (PDA). METHODS: In this prospective, non-randomized study, consecutive patients with large PDA (narrowest diameter: ≥3.5/4.0 mm in symptomatic/asymptomatic patients, respectively), who underwent TCC with Cocoon Duct Occluder at our institute between November, 2012 and June, 2016 were examined...
November 2017: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29142358/transitional-cell-carcinoma-of-urinary-bladder-manifesting-as-extensive-retroperitoneal-and-axillary-lymph-node-metastasis-an-extremely-rare-case-scenario-detected-by-18-f-fluorodeoxyglucose-positron-emission-tomography-scan
#2
Abhishek Purkayastha, Neelam Sharma, Rekha Vashisth, Braj Kishore
Transitional cell carcinoma (TCC) urinary bladder is known to metastasize to regional lymph nodes (LNs), liver, lung, bone, adrenal glands, and intestine. However, an asymptomatic TCC bladder manifesting as metastatic axillary LN mass and extensive retroperitoneal lymphadenopathy is rarely heard of. A 46-year-old male, smoker, presented with 8 cm × 6 cm right axillary swelling of 1-month duration. Aspiration cytology revealed metastatic deposits of poorly differentiated carcinoma favoring TCC. Metastatic evaluation with (18)F-fluorodeoxyglucose positron emission tomography ((18)FDG-PET) scan showed mass lesion urinary bladder, conglomerate right axillary mass and extensive retroperitoneal LNs with significant metabolic activity, biopsy from which revealed deposits of TCC...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29141625/microrna-profiling-of-dogs-with-transitional-cell-carcinoma-of-the-bladder-using-blood-and-urine-samples
#3
Michael S Kent, Allison Zwingenberger, Jodi L Westropp, Laura E Barrett, Blythe P Durbin-Johnson, Paramita Ghosh, Ruth L Vinall
BACKGROUND: Early signs of canine transitional cell carcinoma (TCC) are frequently assumed to be caused by other lower urinary tract diseases (LUTD) such as urinary tract infections, resulting in late diagnosis of TCC which could be fatal. The development of a non-invasive clinical test for TCC could dramatically reduce mortality. To determine whether microRNAs (miRNAs) can be used as non-invasive diagnostic biomarkers, we assessed miRNA expression in blood and/or urine from dogs with clinically normal bladders (n = 28), LUTD (n = 25), and TCC (n = 17)...
November 15, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29137705/novel-approach-to-high-throughput-determination-of-endocrine-disruptors-using-recycled-diatomaceous-earth-as-a-green-sorbent-phase-for-thin-film-solid-phase-microextraction-combined-with-96-well-plate-system
#4
Nicolas Kirschner, Adriana Neves Dias, Dilma Budziak, Cristian Berto da Silveira, Josias Merib, Eduardo Carasek
A sustainable approach to TF-SPME is presented using recycled diatomaceous earth, obtained from a beer purification process, as a green sorbent phase for the determination of bisphenol A (BPA), benzophenone (BzP), triclocarban (TCC), 4-methylbenzylidene camphor (4-MBC) and 2-ethylhexyl-p-methoxycinnamate (EHMC) in environmental water samples. TF-SPME was combined with a 96-well plate system allowing for high-throughput analysis due to the simultaneous extraction/desorption up to 96 samples. The proposed sorbent phase exhibited good stability in organic solvents, as well as satisfactory analytical performance...
December 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29136572/multiple-bioanalytical-method-to-reveal-developmental-biological-responses-in-zebrafish-embryos-exposed-to-triclocarban
#5
Xing Dong, Hai Xu, Xiangyang Wu, Liuqing Yang
Triclocarban (TCC) is a well-known antibacterial agent that is frequently detected in environmental, wildlife and human samples. The potential toxicological effects and action mechanism of TCC on vertebrate development has remained unclear. In the present study, we analyzed phenotypic alterations, thyroid hormone levels, thyroid hormone responsive genes, and proteomic profiles of zebrafish embryos after exposure to a series of concentrations of TCC from 6 h post-fertilization (hpf) to 120 hpf. The most nonlethal concentration (MNLC), lethal concentration 10% (LC10) and lethal concentration 50% (LC50) of TCC for exposures of 96 h were 133...
November 8, 2017: Chemosphere
https://www.readbyqxmd.com/read/29124639/the-variation-of-cloud-amount-and-light-rainy-days-under-heavy-pollution-over-south-china-during-1960-2009
#6
Chuanbo Fu, Li Dan
The ground observation data was used to analyze the variation of cloud amount and light precipitation over South China during 1960-2009. The total cloud cover (TCC) decreases in this period, whereas the low cloud cover (LCC) shows the obvious opposite change with increasing trends. LCP defined as low cloud cover/total cloud cover has increased, and small rainy days (< 10 mm day(-1)) decreased significantly (passing 0.001 significance level) during the past 50 years, which is attributed to the enhanced levels of air pollution in the form of anthropogenic aerosols...
November 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29119559/preoperative-methylprednisolone-increases-plasma-pentraxin-3-early-after-total-knee-arthroplasty-a-randomized-double-blind-placebo-controlled-trial
#7
V Lindberg-Larsen, H Kehlet, K Pilely, J Bagger, M L Rovsing, P Garred
Preoperative glucocorticoid administration reduces the systemic inflammatory response. Pentraxin 3 (PTX3) is a novel inflammatory marker belonging to the humoral arm of innate immunity exerting a potentially protective host response. This study evaluated PTX3 and other complement marker changes after preoperative methylprednisolone (MP) early after total knee arthroplasty (TKA). Seventy patients were randomized (1 : 1) to preoperative intravenous (i.v.) MP 125 mg (group MP) or isotonic saline i.v. (group C)...
October 14, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29113179/blocking-integrin-%C3%AE-1-decreases-adhesion-in-chemoresistant-urothelial-cancer-cell-lines
#8
Stefan Vallo, Jochen Rutz, Miriam Kautsch, Ria Winkelmann, Martin Michaelis, Felix Wezel, Georg Bartsch, Axel Haferkamp, Florian Rothweiler, Roman A Blaheta, Jindrich Cinatl Jr
Treatment failure in metastatic bladder cancer is commonly caused by acquisition of resistance to chemotherapy in association with tumor progression. Since alterations of integrins can influence the adhesive and invasive behaviors of urothelial bladder cancer cell lines, the present study aimed to evaluate the role of integrins in bladder cancer cells with acquired resistance to standard first-line chemotherapy with gemcitabine, and cisplatin. Therefore, four gemcitabine- and four cisplatin-resistant sublines out of a panel of four parental urothelial bladder cancer cell lines (TCC-SUP, HT1376, T24, and 5637) were used...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29110694/effects-of-freezer-storage-time-on-levels-of-complement-biomarkers
#9
Angharad R Morgan, Caroline O'Hagan, Samuel Touchard, Simon Lovestone, B Paul Morgan
BACKGROUND: There is uncertainty regarding how stable complement analytes are during long-term storage at - 80 °C. As part of our work program we have measured 17 complement biomarkers (C1q, C1 inhibitor, C3, C3a, iC3b, C4, C5, C9, FB, FD, FH, FI, TCC, Bb, sCR1, sCR2, Clusterin) and the benchmark inflammatory marker C-reactive protein (CRP) in a large set of plasma samples (n = 720) that had been collected, processed and subsequently stored at - 80 °C over a period of 6.6-10.6 years, prior to laboratory analysis...
November 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29102628/dietary-supplementation-of-biofloc-influences-growth-performance-physiological-stress-antioxidant-status-and-immune-response-of-juvenile-sea-cucumber-apostichopus-japonicus-selenka
#10
Jinghua Chen, Yichao Ren, Guodong Wang, Bin Xia, Yuquan Li
Bioflocs are rich in various probiotics and bioactive compounds, which play an important role in improving growth and health status of aquatic organisms. A 60-day experiment was conducted to investigate the effects of dietary supplementation of biofloc on growth performance, digestive enzyme activity, physiological stress, antioxidant status, expression of immune-related genes and disease resistance of sea cucumber Apostichopus japonicus. Juvenile sea cucumbers were fed five experimental diets containing graded levels of biofloc from 0% to 20% (referred as B0, B5, B10, B15 and B20, respectively)...
November 4, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29101759/association-between-human-papillomavirus-and-transitional-cell-carcinoma-of-the-bladder
#11
Pourya Abdollahzadeh, Seyed Hamid Madani, Sedigheh Khazaei, Soraya Sajadimajd, Babak Izadi, Farid Najafi
PURPOSE: Bladder carcinoma is one of the most common malignancies in worldwide. Among several risk factors, Human Papilloma Virus (HPV) have been presumed to play a causative role in the etiology of bladder cell carcinoma. The aim of this study was to evaluate the involvement of HPV infection in biopsy specimens of patients with transitional cell carcinoma at the west of Iran. MATERIALS AND METHODS: In this study, 97 biopsy specimens including 67 patients with transitional cell carcinoma (TCC) of bladder and 30 cases of control group with the mean age of 63 years were studied using immunohistochemistry to identify HPV...
November 4, 2017: Urology Journal
https://www.readbyqxmd.com/read/29096316/degradation-of-triclosan-and-triclocarban-and-formation-of-transformation-products-in-activated-sludge-using-benchtop-bioreactors
#12
Dana L Armstrong, Nuria Lozano, Clifford P Rice, Mark Ramirez, Alba Torrents
Benchtop bioreactors were run aerobically with activated sludge samples collected from a large municipal wastewater treatment plant (WWTP) to understand how increased hydraulic retention time (HRT), sludge retention time (SRT), and varying treatment temperatures (21°C and 30°C) impact concentrations of the endocrine disrupting antimicrobials triclosan (TCS), triclocarban (TCC), and their transformation products. Samples from the reactors were collected periodically over a 122-196h period and the solid and liquid fraction were separately quantitated for TCS, TCC, and methyltriclosan (MeTCS) and scanned qualitatively for six other transformation products...
October 30, 2017: Environmental Research
https://www.readbyqxmd.com/read/29090027/evaluation-of-multidetector-computed-tomography-in-haematuria
#13
Ranjan Kumar, Raj Kumar Airon, Amit Mittal, Rikki Singal, Kamal Sharma, Samita Singal
AIMS AND OBJECTIVES: (1) To study the role of multidetector computed tomography in patients with haematuria. (2) To correlate multidetector computed tomography findings with clinical outcome/laboratory findings/FNAC and/or operative findings (wherever performed). MATERIAL AND METHODS: The present study was carried out in the Department of Radiodiagnosis, M.M. Institute of Medical Sciences and Research, Mullana, Ambala, from April 2014 to 2016. Fifty patients with complaint of haematuria, referred from various wards and outpatient departments of this institution, were included...
June 2017: Mædica
https://www.readbyqxmd.com/read/29058301/cancer-testis-antigens-as-new-candidate-diagnostic-biomarkers-for-transitional-cell-carcinoma-of-bladder
#14
Mandana Afsharpad, Mohammad Reza Nowroozi, Maryam Beigom Mobasheri, Mohsen Ayati, Leila Nekoohesh, Mojtaba Saffari, Kazem Zendehdel, Mohammad Hossein Modarressi
To evaluate the diagnostic potential of 23 candidate genes, belonging to a category of tumor-specific antigens known as cancer-testis antigens (CTAs), in transitional cell carcinoma (TCC) patients. The expression of 16 known candidate CTAs and seven testis restricted/selective genes, predominantly expressed in the testis, was evaluated by reverse transcriptase-polymerase chain reaction (RT-PCR). Urinary exfoliated cells (UECs) and cancerous tissues of 73 TCC patients were used as cases, while 25 tumor-free adjacent bladder tissue specimens along with bladder tissue specimens and UECs of five non-TCC individuals were analyzed as controls...
October 20, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/29057609/the-efficacy-of-removable-devices-to-offload-and-heal-neuropathic-plantar-forefoot-ulcers-in-people-with-diabetes-a-single-blinded-multicentre-randomised-controlled-trial
#15
Sicco A Bus, Jaap J van Netten, Anke Ir Kottink, Erik A Manning, Maximilian Spraul, Arend-Jan Woittiez, Jeff G van Baal
Non-removable offloading is the 'gold standard' treatment for neuropathic diabetic plantar forefoot ulcers. However, removable offloading is the common 'standard of care'. We compared three removable offloading devices for ulcer healing efficacy. In this multicentre, randomised controlled trial, 60 persons with neuropathic diabetic plantar forefoot ulcers were randomly assigned to wear a custom-made knee-high cast [BTCC (bivalved TCC)], custom-made ankle-high cast shoe or a prefabricated ankle-high forefoot-offloading shoe (FOS)...
October 23, 2017: International Wound Journal
https://www.readbyqxmd.com/read/29050406/microbiological-quality-assessment-and-validation-of-antimicrobials-against-unstressed-or-cold-stress-adapted-salmonella-and-surrogate-enterococcus-faecium-on-broiler-carcasses-and-wings
#16
Lacey Lemonakis, KaWang Li, Jeremy M Adler, Cangliang Shen
This study aims to evaluate the microbiological quality and efficacy of antimicrobials to inactivate unstressed or cold-stress adapted Salmonella and Enterococcus on broiler carcasses and wings processed at a small USDA-inspected slaughter facility in West Virginia. The first part of the study included 42 carcasses that were pre- and secondarily-enriched in bacterial media followed by streak-plating onto XLT-4 and HardyCHROM™-agar Salmonella and confirmation using an API20E-kit. The aerobic plate counts (APC), Escherichia coli (ECC), total coliforms (TCC), and yeast/molds were analyzed on petri-films...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29045805/triclocarban-enhances-short-chain-fatty-acids-production-from-anaerobic-fermentation-of-waste-activated-sludge
#17
Yali Wang, Dongbo Wang, Yiwen Liu, Qilin Wang, Fei Chen, Qi Yang, Xiaoming Li, Guangming Zeng, Hailong Li
Triclocarban (TCC), one typical antibacterial agent being widely used in various applications, was found to be present in waste activated sludge at significant levels. To date, however, its effect on anaerobic fermentation of sludge has not been investigated. This work therefore aims to fill this knowledge gap. Experimental results showed that when TCC content in sludge increased from 26.7 ± 5.3 to 520.5 ± 12.6 mg per kilogram total suspended solids, the maximum concentration of short-chain fatty acids (SCFA) increased from 32...
October 6, 2017: Water Research
https://www.readbyqxmd.com/read/29027081/fate-of-triclocarban-in-agricultural-soils-after-biosolid-applications
#18
Nuria Lozano, Clifford P Rice, Mark Ramirez, Alba Torrents
Triclocarban [N-(4-chlorophenyl)-N-(3,4-dichlorophenyl) urea] (TCC) is an antimicrobial agent utilized in a variety of consumer products. It is commonly released into domestic wastewaters and upon treatment, it is known to accumulate in biosolids. This study examines the occurrence of TCC in biosolids and its long-term fate in biosolid-treated soils. TCC levels in the biosolids from a large waste water treatment plant (WWTP) over 2 years showed little variability at 18,800 ± 700 ng g(-1) dry wt. (mean ± SEM)...
October 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29019431/synthesis-and-spectroscopic-characterization-study-of-new-palladium-complexes-containing-bioactive-o-o-chelated-ligands-evaluation-of-the-dna-protein-bsa-interaction-in-vitro-antitumoral-activity-and-molecular-docking
#19
Kazem Karami, Zohreh Mehri Lighvan, Hossein Farrokhpour, Maryam Dehdashti Jahromi, Amir Abbas Momtazi-Borojeni
[Pd{(C,N)-C6H4CH2NH(Et) (Qu)] (2) and [Pd{(C,N)-C6H4CH2NH(Et) (Nar)] (3) (Qu=Quercetin, Nar=Naringin) mononuclear palladium (II) complexes have been synthesized and characterized using elemental analysis, IR and electronic spectroscopy. The interaction of the prepared complexes with calf thymus DNA (CT DNA) and bovine serum albumin (BSA), monitored by UV-visible and fluorescence titrations, respectively, have been carried out to better understand the mode of their action under biological conditions. Intercalative binding mode between the complexes and DNA is suggested by the binding constant (Kb) values of 2...
October 11, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28971891/embryo-cell-allocation-patterns-are-not-altered-by-biopsy-but-can-be-linked-with-further-development
#20
Lessly Pilar Sepulveda-Rincon, Nadia Islam, Peter Marsters, Bruce K Campbell, Nathalie Beaujean, Walid E Maalouf
It has been suggested that first embryo cleavage can be related with the embryonic-abembryonic axis at blastocyst stage in mice. Thus, cells of the 2 cell embryo might be already biased to form the inner cell mass or trophectoderm. This study was conducted to observe the possible effects of embryo biopsy on cell allocation patterns during embryo pre-implantation in two different mouse strains and the effects of these patterns on further development. First, one blastomere of the 2-cell embryo was injected with a lipophilic tracer and cell allocation patterns were observed at blastocyst stage...
September 29, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
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