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Susana Barros, Rosa Montes, José Benito Quintana, Rosario Rodil, Jorge M A Oliveira, Miguel M Santos, Teresa Neuparth
Triclocarban (TCC), a common antimicrobial agent widely used in many household and personal care products, has been widely detected in aquatic ecosystems worldwide. Due to its high lipophilicity and persistence in the aquatic ecosystems, TCC is of emerging environmental concern. Despite the frequently reported detection of TCC in the environment and significant uncertainties about its long term effects on aquatic ecosystems, few studies have addressed the chronic effects of TCC in aquatic organisms at ecologically relevant concentrations...
October 14, 2016: Ecotoxicology and Environmental Safety
Tatjana Harting, Mandy Stubbendorff, Saskia Willenbrock, Siegfried Wagner, Patrik Schadzek, Anaclet Ngezahayo, Hugo Murua Escobar, Ingo Nolte
The Warburg effect describes the ability of cancer cells to produce energy via aerobic glycolysis instead of oxidative phosphorylation of pyruvate. This deviation in mitochondrial metabolism inhibits apoptosis, allowing increased proliferation under conditions of reduced oxygen levels. Dichloroacetate (DCA) was successfully used in several human cancer cell lines to reactivate oxidative phosphorylation in mitochondria. The aim of this study was the characterization and response of canine cancer cell lines after DCA exposure...
October 5, 2016: International Journal of Oncology
Dineke Westra, Elena B Volokhina, Renate G van der Molen, Thea J A M van der Velden, Annelies Jeronimus-Klaasen, Joop Goertz, Valentina Gracchi, Eiske M Dorresteijn, Antonia H M Bouts, Mandy G Keijzer-Veen, Joanna A E van Wijk, Jaap A Bakker, Anja Roos, Lambert P van den Heuvel, Nicole C A J van de Kar
BACKGROUND: The role of complement in the atypical form of hemolytic uremic syndrome (aHUS) has been investigated extensively in recent years. As the HUS-associated bacteria Shiga-toxin-producing Escherichia coli (STEC) can evade the complement system, we hypothesized that complement dysregulation is also important in infection-induced HUS. METHODS: Serological profiles (C3, FH, FI, AP activity, C3d, C3bBbP, C3b/c, TCC, αFH) and genetic profiles (CFH, CFI, CD46, CFB, C3) of the alternative complement pathway were prospectively determined in the acute and convalescent phase of disease in children newly diagnosed with STEC-HUS or aHUS...
October 7, 2016: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Neha S Shah, S Y Grace Lin, Pennan M Barry, Yi-Ning Cheng, Gisela Schecter, Ed Desmond
Background.  Data from international settings suggest that isolates of Mycobacterium tuberculosis with rpoB mutations testing phenotypically susceptible to rifampin (RIF) may have clinical significance. We analyzed treatment outcomes of California patients with discordant molecular-phenotypic RIF results. Methods.  We included tuberculosis (TB) patients, during 2003-2013, whose specimens tested RIF susceptible phenotypically but had a rpoB mutation determined by pyrosequencing. Demographic data were abstracted from the California TB registry...
September 2016: Open Forum Infectious Diseases
Sue-Jie Koo, Imran Chowdhury, Bartosz Szczesny, Xianxiu Wan, Nisha J Garg
BACKGROUND: Trypanosoma cruzi is the causative agent of chronic chagasic cardiomyopathy. Why macrophages (mϕs), the early responders to infection, fail to achieve parasite clearance is not known. METHODS: Mouse (RAW 264.7) and human (THP-1 and primary) mϕs were infected with T. cruzi TcI isolates, SylvioX10/4 (SYL, virulent) and TCC (non-pathogenic), for 3 h and 18 h that represent mϕ stimulation and infection states, respectively. Mϕs incubated with LPS/IFN-γ and IL-4 were used as controls...
October 3, 2016: Infection and Immunity
Silvio Aprile, Rossana Canavesi, Michele Bianchi, Giorgio Grosa, Erika Del Grosso
A stability indicating high performance liquid chromatography method has been developed for the determination of thiocolchicoside (TCC) and its main degradation products thiocolchicoside S-oxide (D1SO) and 3-O-demethylthiocolchicine (D3) in liquid and solid formulations. The method was developed based on a previous forced degradation study showing that TCC underwent chemical degradation by acid/base catalyzed hydrolysis and oxidation being the main degradation products D3 and D1SO respectively. The analytes separation and quantification were achieved on a Synergi™ 4μm Polar-RP 80Å, column 150×4...
September 26, 2016: Journal of Pharmaceutical and Biomedical Analysis
Rebekah C Kennedy, Russell R Fling, Michael S Robeson, Arnold M Saxton, Robert L Donnell, John L Darcy, David A Bemis, Jiang Liu, Ling Zhao, Jiangang Chen
Alteration of gut microbial colonization process may influence susceptibility of the newborn/infant to infectious and chronic disease. Infectious disease risk leads to widespread use of non-prescription antimicrobials in household products such as Triclocarban (TCC), an antimicrobial compound in personal care products. TCC concentrates in and is transferred through the milk to suckling offspring. TCC exposure during gestation and lactation significantly reduced phylogenetic diversity (PD) among exposed dams and neonates...
2016: Scientific Reports
Ibrahim El-Battrawy, Martin Borggrefe, Ibrahim Akin
Takotsubo cardiomyopathy (TTC), initially defined as a benign disease, is associated with several complications. One of them is a thromboembolism, which is clinically presented by events such as stroke, ventricular thrombi, and peripheral embolization, and can be present at index event of TCC as well as at any time in disease course. Patients with elevated C-reactive protein levels, markedly elevated D-dimers and severely impaired left ventricular function seem to be at higher risk of developing thrombemboli...
October 2016: Heart Failure Clinics
David A Goldfarb
No abstract text is available yet for this article.
October 2016: Journal of Urology
A J Phipps, D S Beggs, A J Murray, P D Mansell, M A Stevenson, M F Pyman
One of the major challenges for dairy producers is to produce, harvest, and store high-quality colostrum and feed it to their replacement heifer calves. Limited published data are available in Australia regarding the relationship between colostrum management, hygiene, and quality. The objectives of this study were to investigate (1) the colostrum storage and handling practices carried out on farm; (2) the immunoglobulin concentration and bacterial composition of colostrum being fed to replacement dairy heifer calves; (3) the percentage of colostrum being fed to replacement dairy heifer calves that meet industry recommendations; and (4) risk factors for bacterial contamination of colostrum...
September 7, 2016: Journal of Dairy Science
Svetlana Hakobyan, Sebastian Luppe, David Rs Evans, Katharine Harding, Samantha Loveless, Neil P Robertson, B Paul Morgan
BACKGROUND: Multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) are autoimmune inflammatory demyelinating diseases of the central nervous system. Although distinguished by clinicoradiological and demographic features, early manifestations can be similar complicating management. Antibodies against aquaporin-4 support the diagnosis of NMOSD but are negative in some patients. Therefore, there is unmet need for biomarkers that enable early diagnosis and disease-specific intervention...
September 9, 2016: Multiple Sclerosis: Clinical and Laboratory Research
Marie Merheb, Elie Gharios, Alaa Younes, Mohamad Al Cheikh, Toufic Chaaban
The aim of this study was to evaluate the effectiveness of total contact casting (TCC) in treating non-healing diabetic foot ulcers in Lebanese diabetic patients. Twenty-three diabetic patients were treated with TCC, and relevant data were collected retrospectively. Sixteen patients were analysed; the average duration of casting was 6 weeks, and 75% of the patients achieved complete ulcer closure without recurrence during one year of follow-up and without any complications. TCC appears to be an effective treatment of diabetic foot ulcers...
September 9, 2016: International Wound Journal
Pingping Wang, Zhongkun Du, Shixiang Gao, Xiaowei Zhang, J P Giesy
Effects of chemical mixtures at environmentally relevant concentrations on endocrine systems of aquatic organisms are of concern. Triclocarban (TCC) and inorganic mercury (Hg(2+)) are ubiquitous in aquatic environments, and are known to interfere with endocrine pathways via different mechanisms of toxic action. However, effects of mixtures of the two pollutants on aquatic organisms and associated molecular mechanisms were unknown. This study examined effects of binary mixtures of TCC and Hg(2+) on histopathological and biochemical alteration of reproductive organs in zebrafish (Danio rerio) after 21 d exposure...
September 6, 2016: Ecotoxicology and Environmental Safety
Maggie W Waung, Simon Akerman, Mark Wakefield, Charlotte Keywood, Peter J Goadsby
INTRODUCTION: Many patients suffering from migraine gain little relief from existing treatments partly because many existing acute and preventive therapies used in migraine have been adopted from other neurologic conditions such as depression or epilepsy. Here, we present data supporting a new migraine-specific target, the mGlu5 receptor. METHODS: We studied the effect of mGlu5 blockade using ADX10059, on neuronal firing in the trigeminocervical complex (TCC) and durovascular effects of nociceptive trigeminovascular activation in the anesthetized rat...
August 2016: Annals of Clinical and Translational Neurology
Fouad Aoun, Hampig Raphael Kourie, Elie El Rassy, Roland van Velthoven
The involvement of the female genital tract in transitional cell carcinoma (TCC) has not been fully elucidated in women, although involvement is usually associated with a poor prognosis. The vagina, in particular, is considered to be the most commonly affected gynecological organ, with an incidence of 4% of total TCC cases. The pathogenesis of vaginal TCC is challenging to determine, although it is essential for the adequate management of the tumor and to determine the appropriate treatment. The present study reports a case of bladder TCC and metachronous vaginal TCC...
September 2016: Oncology Letters
Christoph E Albers, Andrea Schwarz, Markus S Hanke, Karl-Philipp Kienle, Stefan Werlen, Klaus A Siebenrock
BACKGROUND: Although the etiology of primary femoroacetabular impingement (FAI) is considered developmental, the underlying pathogenic mechanisms remain poorly understood. In particular, research identifying etiologic factors associated with pincer FAI is limited. Knowledge of the physiologic growth patterns of the acetabulum during skeletal maturation might allow conclusions on deviations from normal development that could contribute to pincer-related pathomorphologies. QUESTIONS/PURPOSES: In a population of healthy children, we asked if there were any differences related to skeletal maturation with regard to (1) acetabular version; (2) acetabular depth/width ratio; and (3) femoral head coverage in the same children as assessed by MRIs obtained 1 year apart...
September 1, 2016: Clinical Orthopaedics and related Research
Hiromitsu Kitayama, Taro Yokota, Tomohiro Kondo, Junko Sugiyama, Michiaki Hirayama, Yumiko Oyamada, Yasushi Tsuji
Clinicians generally suspect pulmonary tumor embolism (PTE) with uncontrolled carcinomas which often spread to lungs. We, however, experienced an autopsy case of diffuse microscopic PTE despite controlled liver metastases of transitional cell carcinoma (TCC). A 66-year-old man with progressing respiratory symptoms showed almost normal chest findings on computed tomography. Although liver metastases were successfully shrunk by chemotherapy, the patient died from aggressive respiratory failure. An autopsy revealed small pulmonary vessels showing diffuse tumor emboli...
2016: Internal Medicine
Michael E Rezaee, Zubin Shetty, David Pridmore, Chirag N Dave, Sugandh D Shetty
BACKGROUND: Nephroureterectomy is the standard of care for transitional cell carcinoma (TCC) involving the upper urinary tract. However, few published case reports exist describing the surgical treatment of ectopic kidneys with TCC. Surgical removal of a pelvic kidney can be complicated by aberrant vasculature supply, a tortuous ureter and abutting anatomical structures. Thus, it is necessary to determine the most appropriate surgical technique for treatment of pelvic kidneys with suspected malignancy...
2016: J Endourol Case Rep
Wen-Bo Wu, Wei Wang, Yi-Heng Du, Hao Li, Shu-Jie Xia, Hai-Tao Liu
Transitional cell carcinoma (TCC) is the most common type of bladder cancer but its carcinogenesis remains not completely elucidated. Dysregulation of microRNAs (miRNAs) is well known to be involved in the development of various cancers, including TCC, whereas a role of miR-3713 in the pathogenesis of TCC has not been appreciated. Here, we reported that significantly higher levels of matrix metallopeptidase 9 (MMP9), and significantly lower levels of miR-3713 were detected in TCC tissue, compared to the adjacent non-tumor tissue, and were inversely correlated...
2016: Scientific Reports
Ana Beatriz De Abajo Larriba, Ángel Díaz Rodríguez, Javier González-Gallego, Enrique Méndez Rodríguez, María Jesús Álvarez Álvarez, Jessica Capón Álvarez, Beatriz Peleteiro Cobo, Omar Mahmoud Atoui, Serafín De Abajo Olea, Juan Martínez de Mandojana Hernández
Introducción: estimar la prevalencia del tabaquismo y analizar cómo se diagnostican y se trata a los fumadores diagnosticados de EPOC.Métodos: estudio epidemiológico, transversal, multicéntrico (30 centros salud de la provincia de León). Incluyó pacientes mayores de 35 años diagnosticados y tratados de EPOC. Variables analizadas: edad, sexo, hábitat, datos antropométricos, tabaquismo, número de paquetes/año, cooximetría, dependencia (escala analógico-visual), motivación (test de Fagerström), autoeficacia, estado anímico, intentos previos, terapia cognitivo-conductual, tratamiento farmacológico (TSN, bupropión, vareniclina) y recaídas...
2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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