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https://www.readbyqxmd.com/read/28102295/bioactive-compounds-and-antioxidant-activity-of-wolfberry-infusion
#1
Yujing Sun, Japaer Rukeya, Wenyang Tao, Peilong Sun, Xingqian Ye
An infusion of the wolfberry (Lycium barbarum L.) is a traditional Asian herbal tea. This is the most commonly consumed form of dried wolfberry worldwide, yet little scientific information on wolfberry infusions is available. We investigated the effects of making infusions with hot water on the color, the content of bioactive compounds (polysaccharides, polyphenols, flavonoids and carotenoids) and the antioxidant ability of wolfberry infusions. The contents of bioactive compounds and the antioxidant activity of a wolfberry infusion increased with increased infusion temperature and time...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28096925/penile-metastasis-from-primary-transitional-cell-carcinoma-of-the-bladder-sparing-the-urethra
#2
Justin D Oake, Douglas N Drover
Metastatic involvement of the penis is relatively infrequent. Metastasis of transitional cell carcinoma (TCC) is extremely rare. We report a case of bladder TCC with metastases to the penis that spares the urethra - a finding that, to the best of our knowledge, has not been previously reported. Of the documented mechanisms of metastatic transmission to the penis, we suspect the cause was retrograde lymphatic spread. In our case, a 59-year-old male presented to our clinic initially with phimosis and later developed gross hematuria...
November 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28081510/gestational-and-lactational-exposure-to-di-isobutyl-phthalate-via-diet-in-maternal-mice-decreases-testosterone-levels-in-male-offspring
#3
Xiaoyang Wang, Nan Sheng, Ruina Cui, Hongxia Zhang, Jianshe Wang, Jiayin Dai
Phthalates are a large family of ubiquitous environmental chemicals suspected of being endocrine disruptors, with exposure to these chemicals during prenatal and postnatal development possibly resulting in reproductive disorders. Di-isobutyl phthalate (DiBP) is widely used in consumer and industrial products, and although its exposure in the general population has increased in recent years, the mechanisms behind DiBP-induced reproductive disorders in male offspring remain unclear. Here, pregnant mice were exposed to 0 or 450 mg/kg bw/day DiBP via diet from gestation day (GD) 0 to GD21...
January 3, 2017: Chemosphere
https://www.readbyqxmd.com/read/28078501/the-tissue-culture-laboratory-of-dr-george-otto-gey-60%C3%A2-yrs-ago-as-recalled-by-a-former-student
#4
Charles T Ambrose
George Otto Gey was a pioneer in tissue culture, having introduced the roller drum, the HeLa cell line, and the use of human fetal cord serum and beef embryo extract. During his career (1920s-1960s), the field of tissue culture was in its infancy and not yet dependent upon commercial biological supply houses. While the early techniques of cell culture have been greatly improved upon, of historical interest may be personal observations of the Gey Tissue Culture Laboratory, Johns Hopkins Medical School, as recalled by a medical student working there in the 1950s...
January 11, 2017: In Vitro Cellular & Developmental Biology. Animal
https://www.readbyqxmd.com/read/28071967/tobacco-cessation-counseling-within-physical-therapist-practice-results-of-a-statewide-survey-of-florida-physical-therapists
#5
Rose M Pignataro
INTRODUCTION: Tobacco use is the leading preventable risk factor for chronic disease, disability, and premature mortality. People with disabilities experience higher tobacco use and reduced access to services when compared with the general population. The negative impact on treatment outcomes across all practice settings provides a strong incentive for physical therapists (PTs) to engage in tobacco cessation counseling (TCC). METHODS: Prevalence of TCC and barriers toward implementation was explored using an anonymous cross-sectional survey of Florida-licensed PTs...
January 10, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28070317/prevention-of-microbial-hazard-on-fresh-cut-lettuce-through%C3%A2-adoption-of-food-safety-and-hygienic-practices-by%C3%A2-lettuce-farmers
#6
Lateefah A Oyinlola, Adewale O Obadina, Adebukunola M Omemu, Olusola B Oyewole
Lettuce is consumed raw in salads and is susceptible to microbial contamination through environment, agricultural practices, and its morphology, thus, a potential vehicle for food-borne illness. This study investigated the effect of adoption of food safety and hygienic practices by lettuce farmers on the microbial safety of field sourced lettuce in Lagos State, Nigeria. Ten structured questionnaires were administered randomly to 10 lettuce farmers to assess food safety and hygienic practices (FSH). Two farmers who practice FSH and two farmers who do not practice NFSH were finally used for this study...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28067347/fc-microparticles-can-modulate-the-physical-extent-and-magnitude-of-complement-activity
#7
Brandon Alexander Holt, Michael C Bellavia, Daniel Potter, David White, Sean R Stowell, Todd Sulchek
The complement system is an integral component of the humoral immune system, and describes a cascade of interacting proteins responsible for the opsonization and lysis of foreign pathogens, in addition to the recruitment of immune cells. However, complement activation is also implicated in the progression and complication of immune dysfunctions such as sepsis. Microparticle (MP) biomaterials capable of tuning the local magnitude of serum complement activation could improve complement-mediated cytotoxicity to serum-resistant bacteria or calm an overactive immune response during sepsis...
January 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28062459/biofilm-composition-and-threshold-concentration-for-growth-of-legionella-pneumophila-on-surfaces-exposed-to-flowing-warm-tap-water-without-disinfectant
#8
Dick van der Kooij, Geo L Bakker, Ronald Italiaander, Harm R Veenendaal, Bart A Wullings
: Legionella pneumophila in potable-water installations poses a potential health risk, but quantitative information about its replication in biofilms in relation to water quality is scarce. Therefore, biofilm formation on surfaces of glass and chlorinated polyvinyl chloride (CPVC) in contact with tap water at 34-39°C was investigated under controlled hydraulic conditions in a model system inoculated with biofilm-grown L. pneumophila The biofilm on glass (average steady-state concentration: 23 ± 9 pg ATP cm(-2)) exposed to treated aerobic groundwater [0...
January 6, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28056447/influence-of-thermal-hydrolysis-anaerobic-digestion-treatment-of-wastewater-solids-on-concentrations-of-triclosan-triclocarban-and-their-transformation-products-in-biosolids
#9
Dana L Armstrong, Clifford P Rice, Mark Ramirez, Alba Torrents
The growing concern worldwide regarding the presence of emerging contaminants in biosolids calls for a better understanding of how different treatment technologies at water resource recovery facilities (WRRFs) can influence concentrations prior to biosolids land application. This study focuses on the influence of solids treatment via the Cambi Thermal Hydrolysis Process™ in conjunction with anaerobic digestion (TH-AD) on concentrations of triclosan (TCS), triclocarban (TCC), and their transformation products in biosolids and sludges...
December 26, 2016: Chemosphere
https://www.readbyqxmd.com/read/28047891/th-ab-202-04-auto-adaptive-margin-generation-for-mlc-tracked-radiotherapy
#10
M Glitzner, M Fast, B Denis de Senneville, S Nill, U Oelfke, J Lagendijk, B Raaymakers, S Crijns
PURPOSE: To develop an auto-adaptive margin generator for MLC tracking. The generator is able to estimate errors arising in image guided radiotherapy, particularly on an MR-Linac, which depend on the latencies of machine and image processing, as well as on patient motion characteristics. From the estimated error distribution, a segment margin is generated, able to compensate errors up to a user-defined confidence. METHOD: In every tracking control cycle (TCC, 40ms), the desired aperture D(t) is compared to the actual aperture A(t), a delayed and imperfect representation of D(t)...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28039579/discordance-of-somatic-mutations-between-asian-and-caucasian-patient-populations-with-gastric-cancer
#11
Feifei Jia, Jamie K Teer, Todd C Knepper, Jae K Lee, Hong-Hao Zhou, Yi-Jing He, Howard L McLeod
BACKGROUND: Differences in response to cancer treatments have been observed among racially and ethnically diverse gastric cancer (GC) patient populations. In the era of targeted therapy, mutation profiling of cancer is a crucial aspect of making therapeutic decisions. Mapping driver gene mutations for the GC patient population as a whole has significant potential to advance precision therapy. METHODS: GC patients with sequencing data (N = 473) were obtained from The Cancer Genome Atlas (TCGA; n = 295), Moffitt Cancer Center Total Cancer Care™ (TCC; n = 33), and three published studies (n = 145)...
December 30, 2016: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/28036156/interleukin-4-cytokine-single-nucleotide-polymorphisms-in-kawasaki-disease-a-case-control-study-and-a-review-of-knowledge
#12
Raheleh Assari, Yahya Aghighi, Vahid Ziaee, Maryam Sadr, Arezou Rezaei, Farzaneh Rahmani, Zeinab Sadr, Seyed Reza Raeeskarami, Mohammad Hassan Moradinejad, Nima Rezaei
AIM: Kawasaki disease (KD) is a systemic vasculitis of medium-sized arteries. High levels of interleukin 4 (IL-4) and the dominance of Th2 cytokines seem to be a key feature in the acute phase of KD. In this study, the role of IL-4 and IL-4R gene polymorphisms were investigated in Iranian children with KD. METHODS: Fifty-five patients with KD and 140 healthy subjects as a control group were enrolled in this study. Single nucleotide polymorphisms (SNPs) of IL-4 gene at positions -1098 (rs2243248), -590 (rs2243250) and -33 (rs2070874), as well as IL-4RA gene at position +1902 (rs180275) were assessed in patients and the control group...
December 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28031042/transitional-cell-carcinoma-with-extension-of-the-renal-vein-and-ivc-tumor-thrombus-report-of-three-cases-and-literature-review
#13
Mingyang Li, An Shi, Wen Kong, Jin Zhang, Yonghui Chen, Jiwei Huang, Yiran Huang
BACKGROUND: Transitional cell carcinoma (TCC) originating from the renal pelvis with a venous tumor thrombus is a rare entity. However, clinicians should be aware of it because of its high malignancy and poor prognosis. CASE PRESENTATION: Here, we report three cases of pathologically confirmed TCC originating from the renal pelvis with extension into the renal vein or inferior vena cava (IVC). Of these patients, two are males and one is female (58~73 years old)...
December 28, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28027984/high-carotenoids-content-can-enhance-resistance-of-selected-pinctada-fucata-families-to-high-temperature-stress
#14
Zihao Meng, Bo Zhang, Baosuo Liu, Haimei Li, Sigang Fan, Dahui Yu
Carotenoids are a class of natural antioxidants widely found in aquatic, and they have significant effects on the growth, survival, and immunity of these organisms. To investigate the mechanisms of carotenoids in high temperature resistance, we observed the immune response of selected pearl oyster Pinctada fucata (Akoya pearl oyster) families with different carotenoids contents to high temperature stress. The results indicated that the survival rate (SR) of P. fucata decreased significantly with increase in temperature from 26 °C to 34 °C and with the decrease of total carotenoids content (TCC); when the TCC was higher, the SR tended to be higher...
December 24, 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28025031/triclosan-triclocarban-levels-in-maternal-and-umbilical-blood-samples-and-their-association-with-fetal-malformation
#15
Ling Wei, Pengyun Qiao, Ying Shi, Yan Ruan, Jie Yin, Qingqing Wu, Bing Shao
Triclosan (TCS) and triclocarban (TCC) are widely used as antimicrobial compounds in consumer products. TCS and TCC are frequently found in waste water and sewage. In this study, we investigate the potential impact of exposure to triclosan (TCS) and triclocarban (TCC) on fetal abnormalities. We measured TCS and TCC levels in maternal and umbilical cord blood samples from 39 pregnant women diagnosed with fetal or post-birth abnormalities at Beijing Obstetrics and Gynecology Hospital. 52 pregnant women who gave birth to healthy neonates during the same period of time were included as controls...
December 23, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27993569/a-genome-based-model-for-adjusting-radiotherapy-dose-gard-a-retrospective-cohort-based-study
#16
Jacob G Scott, Anders Berglund, Michael J Schell, Ivaylo Mihaylov, William J Fulp, Binglin Yue, Eric Welsh, Jimmy J Caudell, Kamran Ahmed, Tobin S Strom, Eric Mellon, Puja Venkat, Peter Johnstone, John Foekens, Jae Lee, Eduardo Moros, William S Dalton, Steven A Eschrich, Howard McLeod, Louis B Harrison, Javier F Torres-Roca
BACKGROUND: Despite its common use in cancer treatment, radiotherapy has not yet entered the era of precision medicine, and there have been no approaches to adjust dose based on biological differences between or within tumours. We aimed to assess whether a patient-specific molecular signature of radiation sensitivity could be used to identify the optimum radiotherapy dose. METHODS: We used the gene-expression-based radiation-sensitivity index and the linear quadratic model to derive the genomic-adjusted radiation dose (GARD)...
December 18, 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27993073/occurrence-of-triclocarban-and-triclosan-in-an-agro-ecosystem-following-application-of-biosolids
#17
Jessica J Sherburne, Amanda M Anaya, Kim J Fernie, Jennifer S Forbey, Edward T Furlong, Dana W Kolpin, Alfred M Dufty, Chad A Kinney
Triclocarban (TCC) and triclosan (TCS), two of the most commonly used antimicrobial compounds, can be introduced into ecosystems by applying wastewater treatment plant biosolids to agricultural fields. Concentrations of TCC and TCS were measured in different trophic levels within a terrestrial food web encompassing land-applied biosolids, soil, earthworms (Lumbricus), deer mice (Peromyscus maniculatus), and eggs of European starlings (Sturnus vulgaris) and American kestrels (Falco sparverius) at an experimental site amended with biosolids for the previous 7 years...
December 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27989288/the-social-determinants-of-health-core-taking-a-place-based-approach
#18
Richard A Scribner, Neal R Simonsen, Claudia Leonardi
INTRODUCTION: There is growing recognition that health disparities research needs to incorporate social determinants in the local environment into explanatory models. In the transdisciplinary setting of the Mid-South Transdisciplinary Collaborative Center (TCC), the Social Determinants of Health (SDH) Core developed an approach to incorporating SDH across a variety of studies. This place-based approach, which is geographically based, transdisciplinary, and inherently multilevel, is discussed...
January 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27966913/functional-characterization-of-a-novel-amidase-involved-in-biotransformation-of-triclocarban-and-its-dehalogenated-congeners-in-ochrobactrum-sp-tcc-2
#19
Hui Yun, Bin Liang, Jiguo Qiu, Long Zhang, Youkang Zhao, Jiandong Jiang, Aijie Wang
Haloaromatic antimicrobial triclocarban (3,4,4'-trichlorocarbanilide, TCC) is a refractory contaminant which is frequently detected in various aquatic and sediment environments globally. However, few TCC-degrading communities or pure cultures have been documented, and functional enzymes involved in TCC biodegradation hitherto have not yet been characterized. In this study, a bacterial strain, Ochrobactrum sp. TCC-2, capable of degrading TCC under both aerobic and anaerobic conditions was isolated from a sediment sample...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/27942889/off-loading-strategies-in-diabetic-foot-syndrome-evaluation-of-different-devices
#20
Jürgen Götz, Mario Lange, Silvia Dullien, Joachim Grifka, Gernot Hertel, Clemens Baier, Franz Koeck
INTRODUCTION: Diabetic foot syndrome is one of the most dreaded complications in diabetes mellitus. The purpose of this study was to assess the value of different offloading devices compared to walking in barefoot condition and in normal shoes both in healthy subjects and in patients with diabetes and neuropathy. METHODS: Twenty patients with diabetes and polyneuropathy and ten healthy probands were included. Pedobarographic examination was performed in barefoot condition, with sneakers, postoperative shoes, Aircast® Diabetic Pneumatic Walker™ and VACO®diaped...
December 9, 2016: International Orthopaedics
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