keyword
MENU ▼
Read by QxMD icon Read
search

1HNMR

keyword
https://www.readbyqxmd.com/read/27831926/biodegradation-of-micropollutant-naproxen-with-a-selected-fungal-strain-and-identification-of-metabolites
#1
Y Doruk Aracagök, Hakan Göker, Nilüfer Cihangir
Pharmaceuticals are widely used for treating human and animal diseases. Naproxen [(S) 6-methoxy-α-methyl-2-naphthalene acetic acid] and its sodium salt are members of the α-arylpropionic acid group of nonsteroidal anti-inflammatory drugs. Due to excessive usage of naproxen, this drug has been determined even in drinking water. In this study, four fungal strains Phanerochaete chrysosporium, Funalia trogii, Aspergillus niger, and Yarrowia lipolytica were investigated in terms of naproxen removal abilities. According to LC/MS data, A...
November 10, 2016: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/27731819/synthesis-antibacterial-and-antifungal-possession-of-amino-acids-containing-sulfonamide-moieties
#2
Muhammad Abdul Qadir, Mahmood Ahmed, Anum Khaleeq
Sulfonamides were developed by the simple reaction of amino acid with p-toluenesulfonyl chloride and structures of the new products (2a, 2b and 2c) were confirmed by elemental and spectral analysis (FT-IR, 1HNMR and13CNMR). In vitro, developed compounds were screened for their antibacterial and antifungal activities against two sensitive bacteria belonging to both gram positive and gram-negative types and two fungi. The synthesized sulfonamides (2a, 2b, 2c) exhibited excellent antifungal activities against the tested fungi...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27602433/hyphenating-centrifugal-partition-chromatography-with-nuclear-magnetic-resonance-through-automated-solid-phase-extraction
#3
Jonathan Bisson, Marion Brunel, Alain Badoc, Grégory Da Costa, Tristan Richard, Jean-Michel Mérillon, Pierre Waffo-Téguo
Centrifugal partition chromatography (CPC) and all countercurrent separation apparatus provide chemists with efficient ways to work with complex matrixes, especially in the domain of natural products. However, despite the great advances provided by these techniques, more efficient ways of analyzing the output flow would bring further enhancement. This study describe a hyphenated approach made by coupling NMR with CPC through a hybrid-indirect coupling made possible by using a solid phase extraction (SPE) apparatus intended for high-pressure liquid chromatography (HPLC)-NMR hyphenation...
October 18, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27585831/docking-molecular-dynamics-simulation-and-synthesis-of-new-fenobam-analogues-as-mglu5-receptor-antagonists
#4
Abdollah Javidan, Mohammadjavad Taghizadeh, Ayub Hosseini, Maryam Iman, Rahim Jafari
Fenobam is a non-competitive mGluR5 antagonist as an anxiolytic agent. In this research a new series of fenobam analogues containing thiazole moiety instead of imidazole ring were designed and synthesized. The ureido-substituted products were synthesized from reaction of amino thiazole derivatives and isocyanate derivatives in dichloromethane solvent under microwave and ultrasonic irradiation condition. The synthesized compounds structures were established by means of IR, 1HNMR, 13CNMR spectroscopic data. Then, docking calculations were performed on the active site of mGLuR5 and compared to Fenobam as a reference drug by using AutoDock program...
August 31, 2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27455771/novel-long-circulating-liposomes-consisting-of-peg-modified-%C3%AE-sitosterol-for-gambogic-acid-delivery
#5
Fan Yu, Xinhui Tang
Long-circulating liposome is an effective formulation in field of cancer treatment. However, high expenditure of formulation and high dose of cholesterol severely restrict its application. In this paper, we developed a method by grafting polyethylene glycol 2000 on β-sitosterol succinic anhydride ester to obtain relatively cheap polyethylene glycol-β-sitosterol conjugates, which were used to prepare long-circulating liposome without cholesterol. Gambogic acid which is an effective antitumor ingredient with very short half-life, was used as a model drug to prepare long-circulating liposome in this research...
March 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27399233/1hnmr-based-discriminatory-analysis-of-eurycoma-longifolia-from-different-locations-and-establishing-a-profile-for-primary-metabolites-identification-and-quassinoids-quantification
#6
Forough Ebrahimi, Baharudin Ibrahim, Chin Hoe Teh, Vikneswaran Murugaiyah, Chan Kit Lam
Quassinoids, the major secondary metabolites of Eurycoma longifolia roots, improve male fertility. Hence, it is crucial to investigate their quantitative level in E. longifolia extracts. A profile was established to identify the primary metabolites and major quassinoids, and quantify quassinoids using external calibration curves. Furthermore, the metabolic discrimination of E. longifolia roots from different regions was investigated. The (1)H-NMR spectra of the quassinoids, eurycomanone, eurycomanol, 13,21-dihydroeurycomanone, and eurycomanol-2-O-β-D-glycopyranoside were obtained...
July 11, 2016: Planta Medica
https://www.readbyqxmd.com/read/27398560/antimicrobial-efficacy-of-synthesized-quaternary-ammonium-polyamidoamine-dendrimers-and-dendritic-polymer-network
#7
C K V Zainul Abid, Richa Jackeray, Swati Jain, Sruti Chattopadhyay, S Asif, Harpal Singh
Water treatment to mitigate microbial contaminants is a major challenge across globe paving the way to develop novel antimicrobial compounds. We aim at architecting antibacterial moiety eventually catering to vast water treatment industry. In this research study, quaternary ammonium functionalized polyamidoamine (PAMAM) dendrimer and PAMAM-ethyleneglycol dimethacrylate (EGDMA) dendritic polymer network were synthesized. These materials were characterized by various analytical techniques like ATR-FTIR, 1HNMR, DSC etc...
January 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27333559/experimental-and-computational-study-of-the-thermodynamic-properties-of-trivalent-cobalt-schiff-base-complexes-with-cyclic-amines
#8
Sheida Esmaielzadeh, Leila Azimian, Zohreh Zar
Some cobalt(III) complexes with a potentially tetradentate unsymmetrical NNOS Schiff base ligand have been synthesized and characterized using IR, 1HNMR, UV-Vis spectroscopy and elemental analysis. The equilibrium constants were measured spectrophotometrically for 1:1 adduct formation of the cobalt(III) complexes with some cyclic amines in acetonitrile as solvent at constant ionic strength (I = 0.1 M NaClO4), and at various temperatures. In addition, the ground state geometries of the complexes were optimized using density functional theory (DFT) at B3LYP/6-311G** level...
2016: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/27169287/-comparison-between-astragalus-membranaceus-var-mongholicus-and-hedysarum-polybotrys-based-on-its-sequences-and-metabolomics
#9
COMPARATIVE STUDY
Mei-li Jiao, Zhen-yu Li, Fu-sheng Zhang, Xue-mei Qin
Astragalus membranaceus var. mongholicus and Hedysarum polybotrys belong to different genera, but have similar drug efficacy in traditional Chinese medicine theory, and H. polybotrys was used as the legal A. membranaceus var. mongholicus previously. In this study, similarities and differences between them were analyzed via their ITS/ITS2 fragments information. The ITS (internal transcribed spacer) regions were amplified using polymerase chain reaction and then sequenced in two-way. The alignment lengths of ITS regions were 616 bp, in which 508 loci were consistent, and 103 loci were different, accounting for 82...
December 2015: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
https://www.readbyqxmd.com/read/27107423/nmr-based-fecal-metabolomics-fingerprinting-as-predictors-of-earlier-diagnosis-in-patients-with-colorectal-cancer
#10
Yan Lin, Changchun Ma, Chengkang Liu, Zhening Wang, Jurong Yang, Xinmu Liu, Zhiwei Shen, Renhua Wu
Colorectal cancer (CRC) is a growing cause of mortality in developing countries, warranting investigation into its earlier detection for optimal disease management. A metabolomics based approach provides potential for noninvasive identification of biomarkers of colorectal carcinogenesis, as well as dissection of molecular pathways of pathophysiological conditions. Here, proton nuclear magnetic resonance spectroscopy (1HNMR) -based metabolomic approach was used to profile fecal metabolites of 68 CRC patients (stage I/II=20; stage III=25 and stage IV=23) and 32 healthy controls (HC)...
May 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/26970795/synthesis-characterization-and-biological-studies-of-new-linear-thermally-stable-schiff-base-polymers-with-flexible-spacers
#11
Farah Qureshi, Muhammad Yar Khuhawar, Taj Muhammad Jahangir, Abdul Hamid Channar
Five new linear Schiff base polymers having azomethine structures, ether linkages and extended aliphatic chain lengths with flexible spacers were synthesized by polycondensation of dialdehyde (monomer) with aliphatic and aromatic diamines. The formation yields of monomer and polymers were obtained within 75-92%. The polymers with flexible spacers of n-hexane were somewhat soluble in acetone, chloroform, THF, DMF and DMSO on heating. The monomer and polymers were characterized by melting point, elemental microanalysis, FT-IR, (1)HNMR, UV-Vis spectroscopy, thermogravimetry (TG), differential thermal analysis (DTA), fluorescence emission, scanning electron microscopy (SEM) and viscosities and thermodynamic parameters measurements of their dilute solutions...
2016: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/26902600/new-substituted-derivatives-of-dicarboximides-and-their-cytotoxic-properties
#12
Bożena Kuran, Mariola Napiórkowska, Jerzy Kossakowski, Marcin Cieślak, Julia Kaźmierczak-Barańska, Karolina Królewska, Barbara Nawrot
A large group of aminoalkyl and aminoalkanol derivatives of selected dicarboximides were synthesized and characterized by 1HNMR, 13CNMR and ESI MS spectra analysis. The thirty nine new compounds were tested for their cytotoxic properties in human chronic (K562), acute leukemia (HL-60), and cervical cancer cells (HeLa) as well as in normal endothelial cells (HUVEC). The most promising compounds are 4-[2-(dimethylamino)ethyl]-, (diethylamino) ethyl]-, 4-[2-(piperidin-1-yl)ethyl]-, 4-[3-(dimethylamino)propyl]- and 4-[2-hydroxy-3-(propan- 2-ylamino)propyl]- derivatives of 1,7-diethyl-8,9-diphenyl-4-azatricyclo[5...
2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/26404296/electrochemical-interrogation-of-g3-poly-propylene-thiophenoimine-dendritic-star-polymer-in-phenanthrene-sensing
#13
Hlamulo R Makelane, Oluwakemi Tovide, Christopher E Sunday, Tesfaye Waryo, Emmanuel I Iwuoha
A novel dendritic star-copolymer, generation 3 poly(propylene thiophenoimine) (G3PPT)-co-poly(3-hexylthiophene) (P3HT) star co-polymer on gold electrode (i.e., Au|G3PPT-co-P3HT) was used as a sensor system for the determination of phenanthrene (PHE). The G3PPT-co-P3HT star co-polymer was synthesized via in situ electrochemical co-polymerization of generation 3 poly (propylene thiophenoimine) and poly (3-hexylthiophene) on gold electrode. 1HNMR spectroscopy was used to determine the regioregularity of the polymer composites, whereas Fourier transform infrared spectroscopy and scanning electron microscopy were used to study their structural and morphological properties...
2015: Sensors
https://www.readbyqxmd.com/read/26369096/synthesis-and-characterization-of-hollow-tio2-particles-coated-with-polyimide-brushes-by-click-chemistry
#14
Na Sun, Xiang Zhao, Zhenggang Xiao
In order to improve the compatibility between nanoparticles and polymer matrix, a feasible processing way for grafting polyimides (PI) on the surface of hollow TiO2 particles was developed. Hollow TiO2 spheres were prepared by using polystyrene-methyl acrylic acid latex as a template starting from tetrabutyl titanate. Surface graft of azide-decorated hollow TiO2 spheres with well-defined alkyne-terminated PI were achieved by "click" chemistry in three steps: (1) choloromethylation and azidization of hollow TiO2, (2) preparation of alkyne-terminated PI by polycondensation, (3) click coupling between the azidized hollow TiO2 and the alkyne-terminated PI under the catalysis of CuSO4/sodium ascorbate...
June 2015: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/26142521/synthesis-antimicrobial-and-antifungal-possessions-of-tramadol-esters-in-vitro-studies
#15
Muhammad Abdul Qadir, Mahmood Ahmed, Rabia Ikram
Tramadol esters were prepared by refluxing equimolar concentration of tramadol with leucine and asparagine separately with methanol, sulphuric acid and phthalic anhydride for 10 hours and temperature was maintained at 75°C. After refluxing, the colour of sample solutions were changed from colorless to yellow, blank solution was prepared in the same way as the sample solution except the Tramadol. Both the products and blank were neutralized with sodium carbonate and excess of sodium bicarbonate was precipitated as sodium sulphate, which was washed with acetone...
July 2015: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/26048200/metabolomic-profiles-illuminate-the-efficacy-of-chinese-herbal-da-cheng-qi-decoction-on-acute-pancreatitis-in-rats
#16
Juan Li, Shi-Feng Zhu, Xian-Lin Zhao, Yi-Xia Liu, Mei-Hua Wan, Hui Guo, Yi-Ling Liu, Han-Lin Gong, Guang-Yuan Chen, Wen-Fu Tang
BACKGROUND AND OBJECTIVES: Chinese herbal drug Da-Cheng-Qi decoction (DCQD) has been widely used for decades to treat acute pancreatitis (AP). Previous trials are mostly designed to state the potential mechanisms of the therapeutic effects rather than to detect its whole effect on metabolism. This study aimed to investigate the efficacy of DCQD on metabolism in AP. METHODS: Twenty-two male adult Sprague-Dawley rats were randomized into three groups. AP was induced by retrograde ductal infusion of 3...
July 2015: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/26040296/visual-recognition-of-aliphatic-and-aromatic-amines-using-a-fluorescent-gel-application-of-a-sonication-triggered-organogel
#17
Xuelei Pang, Xudong Yu, Haichuang Lan, Xiaoting Ge, Yajuan Li, Xiaoli Zhen, Tao Yi
A naphthalimide-based fluorescent gelator (N1) containing an alkenyl group has been designed and characterized. This material is able to gelate alcohols via a precipitate-to-gel transformation when triggered with ultrasound for less than 2 min (S-gel). The gelation process in n-propanol was studied by means of absorption, fluorescence, and IR spectra, scanning electron microscopy (SEM) images, and X-ray diffraction patterns. The fluorescence intensity of N1 decreased during the gelation process in a linear relationship with the sonication time...
June 24, 2015: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/25849323/1h-nmr-based-metabolomics-investigation-of-copper-laden-rat-a-model-of-wilson-s-disease
#18
COMPARATIVE STUDY
Jingjing Xu, Huaizhou Jiang, Jinquan Li, Kian-Kai Cheng, Jiyang Dong, Zhong Chen
BACKGROUND AND PURPOSE: Wilson's disease (WD), also known as hepatoleticular degeneration (HLD), is a rare autosomal recessive genetic disorder of copper metabolism, which causes copper to accumulate in body tissues. In this study, rats fed with copper-laden diet are used to render the clinical manifestations of WD, and their copper toxicity-induced organ lesions are studied. To investigate metabolic behaviors of 'decoppering' process, penicillamine (PA) was used for treating copper-laden rats as this chelating agent could eliminate excess copper through the urine...
2015: PloS One
https://www.readbyqxmd.com/read/25830958/theoretical-and-experimental-study-of-organic-nano-material-for-acetate-anion-based-on-1-10-phenanthroline
#19
Xuefang Shang, Yuan Zhao, Xiaofang Wei, Yaqian Feng, Xin Li, Shuyan Gao, Xiufang Xu
New phenanthroline derivatives (1, 2, 3, 4) containing phenol groups have been synthesized and optimized. The nano-material of compound 2 was also developed. Their binding properties were evaluated for various biological anions (F(-), Cl(-), Br(-), I(-), AcO(-) and H(2)PO(4)(-)) by theoretical investigation, UV-vis, fluorescence, (1)HNMR titration experiments and these compounds all showed strong binding ability for AcO(-) without the interference of other anions tested. The anion binding ability could be regularized by electron push-pull properties of the ortho- or para- substituent on benzene...
2015: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/25767315/novel-3-4-methylenedioxybenzene-scaffold-incorporated-1-3-5-trisubstituted-2-pyrazolines-synthesis-characterization-and-evaluation-for-chemotherapeutic-activity
#20
S R Deshpande, S N Nagrale, M V Patil, P S Chavan
A series of novel 3, 4-methylenedioxybenzene scaffold incorporated 1,3,5-trisubstituted-2-pyrazoline derivatives was synthesised as potent antitubercular agents via chalcone intermediates by reaction with hydrazines. The structures of the compounds were confirmed by IR, 1HNMR, 13CNMR and mass spectral data. The novel pyrazolines were screened for in vitro antitubercular activity by almar blue dye method against M. tuberculosis H37Rv. All the compounds exhibited excellent activity that could be due to the presence of 3,4-methylenedioxybenzene frame work in the molecules...
January 2015: Indian Journal of Pharmaceutical Sciences
keyword
keyword
8338
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"