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K U Minchitha, H N Hareesh, N Nagaraju, N Kathyayini
Sulphate modified multiwalled carbon nanotubes (S-MWCNT) and Mesoporous carbon (S-MC) catalysts were prepared by wet impregnation method. These materials were characterized by different analytical techniques such as Powder-XRD, BET surface area analysis, SEM-EDS and TEM analysis to evaluate their bulk and surface properties. Surface acidity of the catalyst was measured by TPD-NH3 technique, as well as n-butyl amine titration. The estimated surface acidity of S-MWCNT and S-MC using n-butyl amine titration was found to be 0...
January 1, 2018: Journal of Nanoscience and Nanotechnology
Michael Cannon, Deepa Khambe, Malgorzata Klukowska, David L Ramsey, Melanie Miner, Tom Huggins, Donald J White
OBJECTIVES: The clinical effects of stannous fluoride (SnF2) dentifrice in reducing symptoms of gingivitis and reducing the virulence of subgingival plaque through suppression of activation of gene expression in toll receptor based reporter cells were previously reported. This study expanded analysis of the clinical study to include evaluation of dentifrice effects on salivary metabolites using 1H Nuclear Magnetic Resonance (1H NMR) systems biology-based metabonomics. METHODS: The clinical design was reported previously (J Clin Dent2017;28:16-26)...
March 2018: Journal of Clinical Dentistry
R Siva Kumar, K V Sravan Kumar, L Kondareddy, K R Yogeshwara, Gangrade Manish, Jayachandran Jeenet, Kanyawar Nitesh
A new sensitive and stability indicating reverse phase high-performance liquid chromatography method has been developed for the quantitative determination of potential impurities of Ledipasvir, active pharmaceutical ingredient. Efficient chromatographic separation was achieved on waters × select column contains C18 stationary phase in gradient mode, quantitation at wavelength of 325 nm and mobile phase A is 50 mM ammonium formate pH 3.5 and mobile phase B is acetonitrile with flow rate 1.2 mL. The method was validated according to International Council for Hormonisation guideline, linearity studies has shown correlation coefficient value greater than 0...
February 21, 2018: Journal of Chromatographic Science
Manideepa Indupalli, Vijayalakshmi Muvva, Ushakiranmayi Mangamuri, Rajesh Kumar Munaganti, Krishna Naragani
A rare actinobacterium was isolated from Nizampatnam mangrove ecosystem of Andhra Pradesh, India, and was screened for its ability to produce bioactive compounds. The potential strain was identified as Saccharomonospora oceani VJDS-3 by polyphasic taxonomy. Purification of the biologically active compounds by column chromatography led to the isolation of three compounds, namely methoxy ethyl cinnamate (ethyl(E)-3-(4-methoxyphenyl)acrylate) ( R1 ), 4-hydroxy methyl cinnamate (methyl(E)-3-(4-hydroxyphenyl)acrylate) ( R2 ) and 4-methylbenzoic acid ( R3 )...
February 2018: 3 Biotech
Ashok Kumar, Deepak, Swati Sharma, Shere Afgan, Rajesh Kumar, Anand Kumar Keshari, Ragini Srivastava
The present paper reports graft copolymerization of N-vinylcaprolactam (NVCL) onto carboxymethylcellulose (CMC) using tert-butyl hydroperoxide (TBHP) initiator in N2 atmosphere. The grafting was found to be highest when concentrations of CMC, NVCL and TBHP were 6.25×10-2 gdm-3 , 10×10-3 moldm-3 and 20×10-5 moldm-3 respectively. The graft copolymer (CMC-g-PNVCL-1) was characterized by FTIR, 1 HNMR, SEM, AFM, XRD and TGA analysis. The antioxidant activity of the graft copolymer was found to be higher (3.81%) than CMC and slightly less (5...
June 2018: International Journal of Biological Macromolecules
Waseem Khalid, Amir Badshah, Arif-Ullah Khan, Humaira Nadeem, Sagheer Ahmed
In the present study, a series of new hydrazone and sulfonamide derivatives of 1,2,4-triazole were synthesized. Initially three 4-substituted-5-(2-pyridyl)-1,2,4-triazole-3-thiones ZE-1(a-c) were treated with ethyl chloroacetate to get the corresponding thioesters ZE-2(a-c), which were reacted with hydrazine hydrate to the respective hydrazides ZE-3(a-c). The synthesized hydrazides were condensed with different aldehydes and p-toluene sulfonylchloride to furnish the target hydrazone derivatives ZE-4(a-c) and sulfonamide derivatives ZE-5(a-c) respectively...
February 7, 2018: Chemistry Central Journal
Kaili Wang, Mengjiao Qi, Chunjing Guo, Yueming Yu, Bingjie Wang, Lei Fang, Mengna Liu, Zhen Wang, Xinxin Fan, Daquan Chen
In this work, novel mitochondrial and CD44 receptor dual-targeting redox-sensitive multifunctional nanoparticles (micelles) based on oligomeric hyaluronic acid (oHA) were proposed. The amphiphilic nanocarrier was prepared by (5-carboxypentyl)triphenylphosphonium bromide (TPP), oligomeric hyaluronic acid (oHA), disulfide bond, and curcumin (Cur), named as TPP-oHA-S-S-Cur. The TPP targeted the mitochondria, the antitumor drug Cur served as a hydrophobic core, the CD44 receptor targeting oHA worked as a hydrophilic shell, and the disulfide bond acted as a connecting arm...
February 2, 2018: Nanoscale Research Letters
Vijayakumar K, Sountharrajan S, Suganya E
Anticancer approaches may employ change of molecular structure to enhance preventive influence of chemical agents. The present examination concerned the potential anticancer impact of modified heterocyclic compounds. A strategy was developed to combine tetrazole moieties from different diamines with 2-aminobenzoic and substituted benzoyl chloride compounds with attention to synthesis, characterization and assessment of cancer preventive activity, applying IR, 1HNMR, 13CNMR and Mass spectra.
January 27, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mansour S Alturki, Ngolui Rene Fuanta, Madison A Jarrard, Judith V Hobrath, Douglas C Goodwin, Thankhoe A Rants'o, Angela I Calderón
Single dose high-throughput screening (HTS) followed by dose-response evaluations is a common strategy for the identification of initial hits for further development. Early identification and exclusion of false positives is a cost-saving and essential step in early drug discovery. One of the mechanisms of false positive compounds is the formation of aggregates in assays. This study evaluates the mechanism(s) of inhibition of a set of 14 compounds identified previously as actives in Mycobacterium tuberculosis (Mt) cell culture screening and in vitro actives in Mt shikimate kinase (MtSK) assay...
February 15, 2018: Bioorganic & Medicinal Chemistry Letters
Shipeng Chen, Baohao Zhang, Nanxiang Zhang, Fengsheng Ge, Bao Zhang, Xiaoji Wang, Jian Song
Formation of supramolecular ionic liquid (IL) gels (ionogels) induced by low-molecular-mass gelators (LMMGs) is an efficient strategy to confine ILs, and the negligible influence of LMMGs on the electrochemical properties of ILs makes ionogels ideal quasisolid electrochemical materials. Furthermore, the stimuli-responsive and self-healing characters of the supramolecular gel can be utilized for the potential development of smart electrochemical materials. However, the poor mechanical properties of supramolecular ionogels reported so far limit their practical applications...
February 14, 2018: ACS Applied Materials & Interfaces
Kashif Mahmood, Khalid Mahmood Zia, Waseem Aftab, Mohammad Zuber, Shazia Tabasum, Aqdas Noreen, Fatima Zia
In this work, chitin-curcumin based polyurethane elastomers (PUEs) were prepared by step growth polymerization technique using hydroxy terminated polybutadiene (HTPB), hexamethylene diisocyanate (HDI), chitin and curcumin. The molecular characterization was done by using FTIR and SS 1 HNMR techniques. The surface morphology and thermal stability was studied by scanning electron microscopy (SEM) and thermal gravimetric analysis (TGA), respectively. Degree of absorption and swelling characters were also determined in water as well as in DMSO...
July 1, 2018: International Journal of Biological Macromolecules
Maali Saad Mokhtar, FakhrEldin O Suliman, Abdalla A Elbashir
The inclusion complexes of imazapyr (IMA) with cucurbit[n]uril, CB[n] (n=6-8), have been investigated. Fluorescence spectroscopy, MALDI-TOF, and 1 HNMR were used to investigate and characterize the inclusion complexation of IMA and CB[n] in solutions. Whereas the solid state complexes have been characterized by Fourier transform infrared spectroscopy (FTIR), and powder X-ray diffraction (PXRD). IMA was found to form 1:1 complexes with CB[n] with association constants ranging from 5.80×102 -2.65×103 . The guest molecule IMA was found to encapsulate into the larger cavities of CB[7] and CB[8], whereas with CB[6] the molecule remains outside the cavity...
April 5, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Zhaozheng Yang, Yan Chen, Gang Li, Zhangmin Tian, Liang Zhao, Xi Wu, Qi Ma, Mingzhe Liu, Peng Yang
DNA three-way junctions (TWJ-DNA) are intermediate structures in DNA replication and/or recombination. They play very important roles in biological processes, but more subtle functions are still unknown due partially to the lack of a fluorescent ligand. In this study, a cationic calix[3]carbazole (2) has been synthesized and its properties of interacting with TWJ-DNA have been evaluated by UV/Vis and fluorescence spectroscopy, circular dichroism (CD), gel electrophoresis, and 1 H NMR studies. The results show that 2 binds to the central hydrophobic cavity of TWJ-DNA...
April 20, 2018: Chemistry: a European Journal
Vijay Beniwal, Anil Kumar
To carry out a chemical reaction between the reactants with largely different polarities, it becomes important to have a reaction medium that possesses both the polar and nonpolar solvation environments. In an attempt to explore the reaction media with such unique polarity properties, the present study provides a thorough understanding of the bipolar solvent media using the aqueous mixtures of amino acid anion-based ionic liquids. The highly polar behavior of the binary mixtures used in the study has been ascribed to the pure ionic liquid state...
December 21, 2017: Journal of Physical Chemistry. B
Leila Hosseinzadeh, Hoda Monaghash, Farahnaz Ahmadi, Nastaran Ghiasvand, Yalda Shokoohinia
Objective: Parkinson's disease, a slowly progressive neurological disease, is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine. The main aspects of researches are the protection of normal neurons against degeneration. Fatty acids (FAs), the key structural elements of dietary lipids, are carboxylic straight chains and notable parameters in nutritional and industrial usefulness of a plant. Materials and Methods: Black cumin, a popular anti-inflammatory and antioxidant food seasoning, contains nonpolar constituents such as FAs which were extracted using hexane...
October 2017: Pharmacognosy Magazine
Fan Yu, Fuguang Jiang, Xinhui Tang, Bochu Wang
OBJECTIVE: The deeper research of N-octyl-N-arginine chitosan (OACS) as intravenous delivery was characterized, cell uptake study, pharmacokinetics, and biodistribution of OACS micelles (GA-OACS) were investigated. SIGNIFICANCE: Gambogic acid (GA) can inhibit the growth of various cancer cells. However, the short elimination half-life time and treatment without targeting limits its application. OACS was synthesized as delivery carrier for GA by us, but the deeper characterization of OACS, such as molecular modeling, pharmacokinetics, and biodistribution were not investigated...
April 2018: Drug Development and Industrial Pharmacy
Raana Farajzadeh, Nosratollah Zarghami, Hamed Serati-Nouri, Zahra Momeni-Javid, Taher Farajzadeh, Sepideh Jalilzadeh-Tabrizi, Shima Sadeghi-Soureh, Neda Naseri, Younes Pilehvar-Soltanahmadi
The aim of this study was to evaluate the efficiency of using a natural substance, curcumin, encapsulated in CD44-targeting hyaluronate-polylactide (HA-PLA) nanoparticles (NPs) for the modulation of macrophage polarity from the pro-inflammatory M1 to anti-inflammatory M2 phenotype. For this purpose, the characterization of the NPs was monitored using1 HNMR, FTIR, DLS and FE-SEM. The effects of curcumin-encapsulated HA-PLA NPs on the viability of LPS/IFN-γ stimulated peritoneal macrophages were determined using MTT assay...
November 28, 2017: Artificial Cells, Nanomedicine, and Biotechnology
Yong Hu, XiaoYong Wu, Xu JinRui
The supramolecular hydrogel based on inclusion complexation between PLA/CS diblock copolymer and β-CD has been demonstrated. The PLA/CS diblock copolymer confirmed by FIIR and 1HNMR were synthesized by in situ polymerization. The supramolecular hydrogel formed due to the complexation of PLA/CS with β-cyclodextrin was demonstrated by XRD and FIIR analysis. These results indicate that the carbonyl groups of PLA can form hydrogen bonds with the hydroxyl groups of β-CD and CS in the complexes. The supramolecular hydrogel presented a porous network structure observed by positive fluorescence microscopy (PFM) was found to be thixotropic and reversibl...
March 2018: International Journal of Biological Macromolecules
Samir Dou, Nathalie Villa-Vialaneix, Laurence Liaubet, Yvon Billon, Mario Giorgi, Hélène Gilbert, Jean-Luc Gourdine, Juliette Riquet, David Renaudeau
The negative impact of heat stress (HS) on the production performances in pig faming is of particular concern. Novel diagnostic methods are needed to predict the robustness of pigs to HS. Our study aimed to assess the reliability of blood metabolome to predict the sensitivity to chronic HS of 10 F1 (Large White × Creole) sire families (SF) reared in temperate (TEMP) and in tropical (TROP) regions (n = 56±5 offsprings/region/SF). Live body weight (BW) and rectal temperature (RT) were recorded at 23 weeks of age...
2017: PloS One
James Kinross, Reza Mirnezami, James Alexander, Richard Brown, Alasdair Scott, Dieter Galea, Kirill Veselkov, Rob Goldin, Ara Darzi, Jeremy Nicholson, Julian R Marchesi
Colon cancer induces a state of mucosal dysbiosis with associated niche specific changes in the gut microbiota. However, the key metabolic functions of these bacteria remain unclear. We performed a prospective observational study in patients undergoing elective surgery for colon cancer without mechanical bowel preparation (n = 18). Using 16 S rRNA gene sequencing we demonstrated that microbiota ecology appears to be cancer stage-specific and strongly associated with histological features of poor prognosis...
August 21, 2017: Scientific Reports
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