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https://www.readbyqxmd.com/read/28718285/strong-blue-emissive-supramolecular-self-assembly-system-based-on-naphthalimide-derivatives-and-its-ability-of-detection-and-removal-of-2-4-6-trinitrophenol
#1
Xinhua Cao, Na Zhao, Haiting Lv, Qianqian Ding, Aiping Gao, Qiangshan Jing, Tao Yi
Two simple and novel gelators (G-P with pyridine and G-B with benzene) with different C-4 substitution groups on naphthalimide derivative have been designed and characterized. Two gelators could form organogels in some solvents or mixed solvents. The self-assembly processes of G-P in mixed solvent of acetonitrile / H2O (1/1, v/v) and G-B in acetonitrile were studied by means of electron microscopy and spectroscopy. The organogel of G-P in mixed solvent of acetonitrile / H2O (1/1, v/v) formed intertwined fiber network, and its emission spectrum had obvious blue shift comparing with that of solution...
July 18, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28623862/stimuli-responsive-mof-with-chemo-switchable-properties-for-colorimetric-detection-of-chcl3
#2
Sayed Ali Akbar Razavi, Mohammad Yaser Masoomi, Ali Morsali
The ligands (3,6-di(pyridin-4-yl)-1,4-dihydro-1,2,4,5-tetrazine), H2DPT, as a pillar spacer and (4,4'-oxybis(benzoic acid)), H2OBA, as a dicarboxylate linker were used to develop a dihydro-tetrazine functionalized pillared-MOF, [Zn(OBA)(H2DPT)0.5].DMF (TMU-34) as functionally convertible stimuli responsive MOF-based Sensor. Sonochemically synthesized powder of TMU-34 was employed in sensing of volatile organic compounds (VOCs). The results show that TMU-34 can act as a solid state naked-eye visual chemosensor for detection of chloroform in liquid and gas phases...
June 17, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28571542/folic-acid-targeted-polymeric-micelles-based-on-tocopherol-succinate-pulluan-as-an-effective-carrier-for-epirubicin-preparation-characterization-and-in-vitro-cytotoxicity-assessment
#3
Farshid Hassanzadeh, Mozhdeh Mehdifar, Jaleh Varshosaz, Ghadam Ali Khodarahmi, Mahboubeh Rostami
BACKGROUND: Chemotherapy still encounters a serious drawback, the lack of selectivity of anticancer drugs toward neoplastic cells, thus, the normal cells are affected by the cytotoxic action of the drugs. This causes a narrow therapeutic index in most anticancer drugs. OBJECTIVE: We describe here the preparation of pullulan-tocopherol succinate-folic acid (Pu-TS-FA) micelles for the first time to targeted delivery of epirubicin (EPI) to Hela and MCF-7 cell lines...
June 1, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28542395/carvacrol-derivatives-as-mushroom-tyrosinase-inhibitors-synthesis-kinetics-mechanism-and-molecular-docking-studies
#4
Zaman Ashraf, Muhammad Rafiq, Humaira Nadeem, Mubashir Hassan, Samina Afzal, Muhammad Waseem, Khurram Afzal, Jalifah Latip
The present work describesthe development of highly potent mushroom tyrosinase inhibitor better than the standard kojic acid. Carvacrol derivatives 4a-f and 6a-d having substituted benzoic acid and cinnamic acidresidues were synthesized with the aim to possess potent tyrosinase inhibitory activity.The structures of the synthesized compounds were ascertained by their spectroscopic data (FTIR, 1HNMR, 13CNMR and Mass Spectroscopy).Mushroom tyrosinase inhibitory activity of synthesized compounds was determined and it was found that one of the derivative 6c possess higher activity (IC50 0...
2017: PloS One
https://www.readbyqxmd.com/read/28479737/flavonoids-from-whole-plant-of-euphorbia-hirta-and-their-evaluation-against-experimentally-induced-gastroesophageal-reflux-disease-in-rats
#5
Shyam Sundar Gupta, Lubna Azmi, P K Mohapatra, Ch V Rao
BACKGROUND: Euphorbia hirta possesses antibacterial, anti-inflammatory, galactogenic, antidiarrheal, antioxidant, hypoglycemic, antiasthmatic, antiamebic, antifungal, and antimalarial activities. OBJECTIVE: The overall objective of the current study was the investigation of the whole plant extract of E. hirta and flavonoids from E. hirta on gastroesophageal reflux disease (GERD) in rats. MATERIALS AND METHODS: The whole plant extract of E...
January 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28420233/novel-hydrogen-bonding-cross-linking-aggregation-induced-emission-water-as-a-fluorescent-ribbon-detected-in-a-wide-range
#6
Ani Wang, Ruiqing Fan, Yuwei Dong, Yang Song, Yuze Zhou, Jianzong Zheng, Xi Du, Kai Xing, Yulin Yang
The development of efficient sensors for detection of the water content in a wide detection range is highly desirable for balance in many industrial processes and products. Presented herein are six novel different substituted Schiff base Zn(II) complexes, which exhibit the remarkable capability to detect traces of water in a wide linear range (most can reach 0-94%, v/v), low detection limit of 0.2% (v/v), and rapid response time of 8 s in various organic solvents by virtue of an unusual water-activated hydrogen-bonding cross-linking AIE (WHCAIE) mechanism...
April 26, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28417902/a-nir-fluorescent-probe-for-the-rapid-detection-of-hg-2-in-living-cells-and-in-vivo-mice-imaging
#7
Jiaoliang Wang, Liping Long, Li Xia, Fang Fang
A near-infrared fluorescent probe NIR-Hg, for the detection of Hg(2+) ion, has been synthesized directly by condensing Changsha dye with 4-Phenyl-3-thiosemicarbazide and the structure has fully characterized by (1)HNMR, (13)CNMR, and ESI-MS. The probe has been designed on the basis of the reaction that Hg(2+) ion promotes thiosemicarbazide to oxazole in aqueous media and had been induced to produce turn-on fluorescence via an irreversible spirolactam ring-opening process. The probe NIR-Hg has exhibited fast response (1 min), high sensitivity with 44-fold fluorescence intensity enhancement under six equivalent amounts of Hg(2+) added, high selectivity over other related metal ions and a low detection limit of 5...
May 11, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28390956/the-structure-of-the-amorphous-matrix-of-keratins
#8
Murat Kadir, Xinwei Wang, Bowen Zhu, Jing Liu, Duane Harland, Crisan Popescu
Various keratin fibers, particularly human hairs, were investigated by transmission electron microscopy, TEM, solid-state (1)H NMR and Transient Electro-Thermal Technique, TET. The results converge to suggest that the matrix of keratin fiber cortex, far from being amorphous, has a well-defined nano-scale grainy structure, the size of these grains being around 2-4nm. The size of the grains appears to strongly depend on the chemical treatment of the fiber, on the temperature and on the relative humidity of the environment, as well as on the physiological factors at the level of fiber production in follicle...
April 5, 2017: Journal of Structural Biology
https://www.readbyqxmd.com/read/28325152/synthesis-computational-and-pharmacological-evaluation-of-n-2-benzoyl-4-chlorophenyl-2-4-substituted-phenyl-piperazin-1-yl-acetamides-as-cns-agents
#9
Shweta Verma, Surendra Kumar, Sushil Kumar
A series of new N-(2-benzoyl-4-chlorophenyl)-2-(4-(substituted phenyl) piperazin-1-yl) acetamides (3a-j) have been synthesized by the chloroacetylation of 2-amino-5-chlorbenzophenone which was further reacted with substituted phenylpiperazine. The chemical structures of the compounds were confirmed on the basis of their TLC, IR, 1HNMR, 13CNMR and by elemental analysis. The physicochemical similarity of the target compounds with respect to standard drug diazepam was assessed by calculating from a set of physicochemical properties using software programs...
March 21, 2017: Central Nervous System Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28259893/evaluation-of-6-chloro-n-3-4-disubstituted-1-3-thiazol-2-3h-ylidene-1-3-benzothiazol-2-amine-using-drug-design-concept-for-their-targeted-activity-against-colon-cancer-cell-lines-hct-116-hct15-and-ht29
#10
Ming-Li Zhu, Cui-Yue Wang, Cheng-Mian Xu, Wei-Ping Bi, Xiu-Ying ZHou
BACKGROUND Colorectal adenocarcinoma is the second leading cause of cancer-related death in the world. The stage of the disease is related to the survival of the patient, and in early phases surgery is the main modality of treatment. The main aim of modern medicinal chemistry is to synthesize small molecules via drug designing, especially by targeting tumor cells. MATERIAL AND METHODS A new series of 19 compounds containing benzothiazole and thiazole were designed. Molecular docking studies were performed on the designed series of molecules...
March 5, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28000563/metabolomics-as-a-functional-tool-in-screening-gastro-intestinal-diseases-where-are-we-in-high-throughput-screening
#11
Rohit Gundamaraju, Ravichandra Vemuri, Rajaraman Eri, Hamilton M Ishiki, Ericsson Coy-Barrera, Nagendra Sastry Yarla, Sócrates Golzio Dos Santos, Mateus Feitosa Alves, José Maria Barbosa Filho, Margareth F F M Diniz, Marcus T Scotti, Luciana Scotti
Identifying novel bio markers in gastro intestinal disease is a promising method where a comprehensive analysis of the metabolome is performed. Metabolomics has evolved enormously in the past decade, paving a path in gastro intestinal disease research, especially diseases which lead to high morbidity and mortality. Metabolomics involves identifying metabolites such as anti-oxidants, and amino acids etc., which are screened in the urine, feces and tissue samples. Certain cases employ advanced tools like GC-MS, 1HNMR and GC-MS/SPME which reveal valuable information concerning disease severity and differentiation...
2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27831926/biodegradation-of-micropollutant-naproxen-with-a-selected-fungal-strain-and-identification-of-metabolites
#12
Y Doruk Aracagök, Hakan Göker, Nilüfer Cihangir
Pharmaceuticals are widely used for treating human and animal diseases. Naproxen [(S) 6-methoxy-α-methyl-2-naphthalene acetic acid] and its sodium salt are members of the α-arylpropionic acid group of nonsteroidal anti-inflammatory drugs. Due to excessive usage of naproxen, this drug has been determined even in drinking water. In this study, four fungal strains Phanerochaete chrysosporium, Funalia trogii, Aspergillus niger, and Yarrowia lipolytica were investigated in terms of naproxen removal abilities. According to LC/MS data, A...
May 1, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/27731819/synthesis-antibacterial-and-antifungal-possession-of-amino-acids-containing-sulfonamide-moieties
#13
Muhammad Abdul Qadir, Mahmood Ahmed, Anum Khaleeq
Sulfonamides were developed by the simple reaction of amino acid with p-toluenesulfonyl chloride and structures of the new products (2a, 2b and 2c) were confirmed by elemental and spectral analysis (FT-IR, 1HNMR and13CNMR). In vitro, developed compounds were screened for their antibacterial and antifungal activities against two sensitive bacteria belonging to both gram positive and gram-negative types and two fungi. The synthesized sulfonamides (2a, 2b, 2c) exhibited excellent antifungal activities against the tested fungi...
September 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27602433/hyphenating-centrifugal-partition-chromatography-with-nuclear-magnetic-resonance-through-automated-solid-phase-extraction
#14
Jonathan Bisson, Marion Brunel, Alain Badoc, Grégory Da Costa, Tristan Richard, Jean-Michel Mérillon, Pierre Waffo-Téguo
Centrifugal partition chromatography (CPC) and all countercurrent separation apparatus provide chemists with efficient ways to work with complex matrixes, especially in the domain of natural products. However, despite the great advances provided by these techniques, more efficient ways of analyzing the output flow would bring further enhancement. This study describe a hyphenated approach made by coupling NMR with CPC through a hybrid-indirect coupling made possible by using a solid phase extraction (SPE) apparatus intended for high-pressure liquid chromatography (HPLC)-NMR hyphenation...
October 18, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/27585831/docking-molecular-dynamics-simulation-and-synthesis-of-new-fenobam-analogues-as-mglu5-receptor-antagonists
#15
Abdollah Javidan, Mohammad Javad Taghizadeh, Seyed Ayoub Hosseini, Maryam Iman, Rahim Jafari
BACKGROUND: Fenobam is a non-competitive mGluR5 antagonist as an anxiolytic agent. OBJECTIVE: In this research a new series of fenobam analogues containing thiazole moiety instead of imidazole ring were designed and synthesized. METHODS: The ureido-substituted products were synthesized from reaction of amino thiazole derivatives and isocyanate derivatives in dichloromethane solvent under microwave and ultrasonic irradiation condition. The synthesized compounds structures were established by means of IR, 1HNMR, 13CNMR spectroscopic data...
2016: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/27455771/novel-long-circulating-liposomes-consisting-of-peg-modified-%C3%AE-sitosterol-for-gambogic-acid-delivery
#16
Fan Yu, Xinhui Tang
Long-circulating liposome is an effective formulation in field of cancer treatment. However, high expenditure of formulation and high dose of cholesterol severely restrict its application. In this paper, we developed a method by grafting polyethylene glycol 2000 on β-sitosterol succinic anhydride ester to obtain relatively cheap polyethylene glycol-β-sitosterol conjugates, which were used to prepare long-circulating liposome without cholesterol. Gambogic acid which is an effective antitumor ingredient with very short half-life, was used as a model drug to prepare long-circulating liposome in this research...
March 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27399233/1hnmr-based-discriminatory-analysis-of-eurycoma-longifolia-from-different-locations-and-establishing-a-profile-for-primary-metabolites-identification-and-quassinoids-quantification
#17
Forough Ebrahimi, Baharudin Ibrahim, Chin Hoe Teh, Vikneswaran Murugaiyah, Chan Kit Lam
Quassinoids, the major secondary metabolites of Eurycoma longifolia roots, improve male fertility. Hence, it is crucial to investigate their quantitative level in E. longifolia extracts. A profile was established to identify the primary metabolites and major quassinoids, and quantify quassinoids using external calibration curves. Furthermore, the metabolic discrimination of E. longifolia roots from different regions was investigated. The (1)H-NMR spectra of the quassinoids, eurycomanone, eurycomanol, 13,21-dihydroeurycomanone, and eurycomanol-2-O-β-D-glycopyranoside were obtained...
January 2017: Planta Medica
https://www.readbyqxmd.com/read/27398560/antimicrobial-efficacy-of-synthesized-quaternary-ammonium-polyamidoamine-dendrimers-and-dendritic-polymer-network
#18
C K V Zainul Abid, Richa Jackeray, Swati Jain, Sruti Chattopadhyay, S Asif, Harpal Singh
Water treatment to mitigate microbial contaminants is a major challenge across globe paving the way to develop novel antimicrobial compounds. We aim at architecting antibacterial moiety eventually catering to vast water treatment industry. In this research study, quaternary ammonium functionalized polyamidoamine (PAMAM) dendrimer and PAMAM-ethyleneglycol dimethacrylate (EGDMA) dendritic polymer network were synthesized. These materials were characterized by various analytical techniques like ATR-FTIR, 1HNMR, DSC etc...
January 2016: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/27333559/experimental-and-computational-study-of-the-thermodynamic-properties-of-trivalent-cobalt-schiff-base-complexes-with-cyclic-amines
#19
Sheida Esmaielzadeh, Leila Azimian, Zohreh Zar
Some cobalt(III) complexes with a potentially tetradentate unsymmetrical NNOS Schiff base ligand have been synthesized and characterized using IR, 1HNMR, UV-Vis spectroscopy and elemental analysis. The equilibrium constants were measured spectrophotometrically for 1:1 adduct formation of the cobalt(III) complexes with some cyclic amines in acetonitrile as solvent at constant ionic strength (I = 0.1 M NaClO4), and at various temperatures. In addition, the ground state geometries of the complexes were optimized using density functional theory (DFT) at B3LYP/6-311G** level...
2016: Acta Chimica Slovenica
https://www.readbyqxmd.com/read/27169287/-comparison-between-astragalus-membranaceus-var-mongholicus-and-hedysarum-polybotrys-based-on-its-sequences-and-metabolomics
#20
COMPARATIVE STUDY
Mei-li Jiao, Zhen-yu Li, Fu-sheng Zhang, Xue-mei Qin
Astragalus membranaceus var. mongholicus and Hedysarum polybotrys belong to different genera, but have similar drug efficacy in traditional Chinese medicine theory, and H. polybotrys was used as the legal A. membranaceus var. mongholicus previously. In this study, similarities and differences between them were analyzed via their ITS/ITS2 fragments information. The ITS (internal transcribed spacer) regions were amplified using polymerase chain reaction and then sequenced in two-way. The alignment lengths of ITS regions were 616 bp, in which 508 loci were consistent, and 103 loci were different, accounting for 82...
December 2015: Yao Xue Xue Bao, Acta Pharmaceutica Sinica
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