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Axial SpA

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https://www.readbyqxmd.com/read/28917996/poor-efficacy-of-tnf-inhibitors-in-non-radiographic-axial-spondyloarthritis-in-the-absence-of-objective-signs-a-bicentric-retrospective-study
#1
Céline Vidal, Cédric Lukas, Bernard Combe, Francis Berenbaum, Yves Marie Pers, Christian Jorgensen, Jérémie Sellam, Jacques Morel
OBJECTIVE: To compare BASDAI 50 response rate to TNFi in axial spondyloarthritis (axSpA) depending on the presence or not of objective signs of axSpA and to look for predictive factors of TNFi efficacy. METHODS: Patients diagnosed with axSpA according to ASAS criteria "clinical arm" and treated between January 2001 and September 2015 with TNFi were included. First group included patients with at least one objective sign such as arthritis, dactylitis, enthesitis, uveitis, inflammatory bowel disease, elevated C-reactive protein or radiological sacroiliitis, and second group included non-radiographic axSpA (nr-axSpA) patients without any objective sign corresponding to patients with inflammatory back pain and either a good response to NSAID or a SpA family history...
September 13, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28880727/prevalence-of-ankylosing-spondylitis-disease-activity-score-asdas-inactive-disease-in-a-cohort-of-patients-treated-with-tnf-alpha-inhibitors
#2
Sara Monti, Monica Todoerti, Veronica Codullo, Ennio Giulio Favalli, Martina Biggioggero, Andrea Becciolini, Carlomaurizio Montecucco, Roberto Caporali
BACKGROUND: Treat to target (T2T), aiming at inactive disease (ID), has become the recommended strategy for axial-SpA (ax-SpA). Using the Ankylosing Spondylitis Disease Activity Score (ASDAS), we assessed the prevalence of ID in ax-SpA patients treated with TNFα inhibitors (TNFi). METHODS: A multicentric, cross-sectional study was performed assessing disease activity status (BASDAI and ASDAS) of consecutive patients with ax-SpA on stable treatment with TNFi for at least six months...
September 7, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28879048/no-evidence-for-a-direct-role-of-hla-b27-in-pathological-bone-formation-in-axial-spa
#3
Barbara Neerinckx, Simon Kollnberger, Jacqueline Shaw, Rik Lories
OBJECTIVE: The strong genetic association between HLA-B27 and ankylosing spondylitis has been known for over 40 years. HLA-B27 positivity is possibly associated with severity of ankylosis. We studied the in vitro and in vivo impact of HLA-B27 in models of chondrogenesis and osteogenesis. METHODS: Different in vitro differentiation systems were used to mimic endochondral and direct bone formation. ATDC5 cells and primary human periosteum-derived cells (hPDCs) were transduced with lentiviral vectors expressing HLA-B27 or HLA-B7...
2017: RMD Open
https://www.readbyqxmd.com/read/28860446/translation-and-cross-cultural-adaptation-of-the-asas-health-index-and-asas-environmental-factors-item-set-into-european-portuguese-language
#4
Eduardo B Cruz, Sofia Ramiro, Pedro Machado, Sandra Sousa, Renata Aguiar, Alexandre Sepriano, Santiago Rodrigues Manica, Uta Kiltz, Jaime C Branco, Fernando M Pimentel-Santos
OBJECTIVE: There is a lack of outcome measures to assess the impact of axial spondyloarthritis (axSpA) on health, function and quality of life. The Assessment of SpondyloArthritis International Society (ASAS) group developed the ASAS Health Index (ASAS-HI) and the ASAS Environmental Factors Item Set (ASAS-EF) to measure functioning and health across all aspects of health that are typically affected and relevant for patients with axSpA, based on the International Classification of Functioning, Disability and Health (ICF)...
August 31, 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28835779/tumor-necrosis-factor-%C3%AE-tnf%C3%AE-inhibitors-in-the-treatment-of-nonradiographic-axial-spondyloarthritis-current-evidence-and-place-in-therapy
#5
REVIEW
Valeria Rios Rodriguez, Denis Poddubnyy
Nonradiographic axial spondyloarthritis (SpA) and radiographic SpA (also known as ankylosing spondylitis) are currently considered as two stages or forms of one disease (axial SpA). The treatment with tumor necrosis factor-α (TNFα) inhibitors has been authorized for years for ankylosing spondylitis. In recent years, most of the anti-TNFα agents have also been approved for the treatment of nonradiographic axial SpA by the European Medicines Agency (EMA) and similar authorities in many countries around the world (but not in the US), increasing the number of possible therapies for this indication...
August 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28830392/prevalence-and-risk-factors-of-low-bone-mineral-density-in-spondyloarthritis-and-prevalence-of-vertebral-fractures
#6
Sandrine Malochet-Guinamand, Bruno Pereira, Zuzana Tatar, Anne Tournadre, Anna Moltó, Maxime Dougados, Martin Soubrier
BACKGROUND: Investigate the prevalence and risk factors of low bone mineral density (BMD) in patients with axial spondyloarthritis as well as investigating the prevalence of vertebral fractures. METHODS: Patients underwent BMD measurements with dual-energy X-ray absorptiometry (DXA) in the anterior-posterior lumbar spine, lateral spine and hip. We screened for vertebral fractures using vertebral fracture assessment, and then checked for syndesmophytes on the VFA images...
August 22, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28790806/perceptions-of-patients-with-rheumatic-diseases-on-the-impact-on-daily-life-and-satisfaction-with-their-medications-rheu-life-a-survey-to-patients-treated-with-subcutaneous-biological-products
#7
Carlos M González, Loreto Carmona, Javier de Toro, Enrique Batlle-Gualda, Antonio I Torralba, María J Arteaga, Luis Cea-Calvo
OBJECTIVE: The aim of this study was to explore perceptions of patients with rheumatic diseases treated with subcutaneous (SC) biological drugs on the impact on daily life and satisfaction with current therapy, including preferred attributes. METHODS: A survey was developed ad hoc by four rheumatologists and three patients, including Likert questions on the impact of disease and treatment on daily life and preferred attributes of treatment. Rheumatologists from 50 participating centers were instructed to handout the survey to 20 consecutive patients with rheumatoid arthritis (RA), axial spondyloarthritis (ax-SpA), or psoriatic arthritis (PsA) receiving SC biological drugs...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28776360/biomarkers-imaging-and-disease-activity-indices-in-patients-with-early-axial-spondyloarthritis-the-italian-arm-of-the-spondyloarthritis-caught-early-space-study
#8
M Lorenzin, A Ortolan, S Vio, M Favero, F Oliviero, M Zaninotto, C Cosma, C Lacognata, L Punzi, R Ramonda
The study aimed to evaluate biomarkers facilitating early diagnosis of axial spondyloarthritis (axSpA) and correlations between them and disease activity parameters and imaging indexes. Patients with low back pain (LBP) (≥3 months, ≤2 years, onset ≤45 years) participating in the Italian arm of the SpondyloArthritis-Caught-Early SPACE study underwent a physical examination, questionnaires, laboratory tests, X-rays and MRI of the spine and sacroiliac joints (SIJ). An expert rheumatologist formulated axSpA diagnosis in accordance with Assessment of SpondyloArthritis International Society (ASAS) criteria...
August 3, 2017: Reumatismo
https://www.readbyqxmd.com/read/28764693/the-relationship-between-demographic-and-disease-related-variables-and-health-related-quality-of-life-in-patients-with-axial-spondyloarthritis
#9
Gudrun Rohde, Kari Hansen Berg, Anne Prøven, Glenn Haugeberg
BACKGROUND: Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease of the spine causing pain, stiffness, loss in physical function, and fatigue. Therefore, the physical and psychological burden of having this chronic disease can reduce the quality of life. We aimed to explore the relationship between demographic- and disease-related variables and health-related quality of life (HRQoL) in patients with ax-SpA. METHODS: Demographic- and disease-related, HRQoL-related and treatment data were collected...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28754402/cardiovascular-risk-factors-in-patients-with-spondyloarthritis-from-northern-european-and-mediterranean-countries-an-ancillary-study-of-the-asas-comospa-project
#10
Clementina López-Medina, Yolanda Jiménez-Gómez, Anna Moltó, Ruxandra Elena Schiotis, Helena Marzo-Ortega, Floris A van Gaalen, Salih Ozgocmen, Maxime Dougados, Jerusalem Calvo-Gutiérrez, M Carmen Castro-Villegas, Eduardo Collantes-Estévez, Pilar Font-Ugalde
OBJECTIVES: The objectives of this study were: (1) to compare the prevalence of cardiovascular disease and cardiovascular risk factors among different phenotypes of spondyloarthritis (SpA); (2) to assess the differences in cardiovascular disease and cardiovascular risk factors between two geographical areas, i.e. Northern Europe vs. Mediterranean region; (3) to identify potential predictive factors for high Framingham Risk Score regarding disease features in SpA and geographical area...
July 25, 2017: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28721093/gout-mimicking-spondyloarthritis-case-report-and-literature-review
#11
Wenji Chen, Yanyan Wang, Yan Li, Zheng Zhao, Lixia Feng, Jian Zhu, Jianglin Zhang, Feng Huang
Gout is clinically characterized by episodes of monoarthritis, which not only typically affects the peripheral joints but also occasionally affect the axial joint, such as the sacroiliac joint (SIJ), and often mimics spondyloarthritis (SpA). Two cases of gout mimicking SpA are presented in the current paper. One patient was a 32-year-old man with a history of asymmetrical oligoarthritis of ankle and metatarsophalangeal joints (MTPJ). He had left gluteal pain for 2 weeks. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed the bone erosion of the left SIJ...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28698330/clinical-characteristics-of-importance-to-outcome-in-patients-with-axial-spondyloarthritis-protocol-for-a-prospective-descriptive-and-exploratory-cohort-study
#12
Rikke Asmussen Andreasen, Lars Erik Kristensen, Torkell Ellingsen, Robin Christensen, Xenofon Baraliakos, Jimmi Wied, Claus Aalykke, Thomas Ulstrup, Berit Schiøttz-Christensen, Hans Christian Horn, Amir Emamifar, Bent Duerlund, Lars Fischer, Inger Marie Jensen Hansen
INTRODUCTION: Spondyloarthritis (SpA) is a heterogeneous spectrum of rheumatic diseases with either predominantly axial inflammatory symptoms of the spine and sacroiliac joints or predominantly peripheral arthritis. The two main entities of axial SpA (axSpA) are ankylosing spondylitis or non-radiographic axSpA (nr-axSpA). Tumour necrosis factor-α inhibitors have revolutionised the treatment of patients with axSpA who failed to respond to non-steroidal anti-inflammatory drugs and physical therapy...
July 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28693033/axial-involvement-according-to-asas-criteria-in-an-observational-psoriatic-arthritis-cohort
#13
Pedro David Carvalho, Florencia Savy, Carmen Moragues, Xavier Juanola, Jesus Rodriguez-Moreno
The definition of axial involvement in psoriatic arthritis (PsA) is still under debate. Currently, the axial spondyloarthritis (SpA) criteria defined by Assessment of Spondyloarthritis International Society (ASAS) may be the most adequate.(1) The aims of present study were to assess axial involvement according to ASAS criteria in an observational PsA cohort and define the clinical characteristics more associated with this kind of involvement. Our study included consecutive patients who had a visit in a tertiary Rheumatology centre...
April 2017: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/28684559/treating-axial-spondyloarthritis-and-peripheral-spondyloarthritis-especially-psoriatic-arthritis-to-target-2017-update-of-recommendations-by-an-international-task-force
#14
Josef S Smolen, Monika Schöls, Jürgen Braun, Maxime Dougados, Oliver FitzGerald, Dafna D Gladman, Arthur Kavanaugh, Robert Landewé, Philip Mease, Joachim Sieper, Tanja Stamm, Maarten de Wit, Daniel Aletaha, Xenofon Baraliakos, Neil Betteridge, Filip van den Bosch, Laura C Coates, Paul Emery, Lianne S Gensler, Laure Gossec, Philip Helliwell, Merryn Jongkees, Tore K Kvien, Robert D Inman, Iain B McInnes, Mara Maccarone, Pedro M Machado, Anna Molto, Alexis Ogdie, Denis Poddubnyy, Christopher Ritchlin, Martin Rudwaleit, Adrian Tanew, Bing Thio, Douglas Veale, Kurt de Vlam, Désirée van der Heijde
Therapeutic targets have been defined for axial and peripheral spondyloarthritis (SpA) in 2012, but the evidence for these recommendations was only of indirect nature. These recommendations were re-evaluated in light of new insights. Based on the results of a systematic literature review and expert opinion, a task force of rheumatologists, dermatologists, patients and a health professional developed an update of the 2012 recommendations. These underwent intensive discussions, on site voting and subsequent anonymous electronic voting on levels of agreement with each item...
July 6, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28682112/etanercept-for-treating-axial-spondyloarthritis
#15
Xavier Guillot, Clément Prati, Maxime Sondag, Daniel Wendling
Axial spondyloarthritis is an inflammatory rheumatic disease causing back pain, functional impairment and potential ankylosis in the advanced stage. In this context, TNF blockers have been a major therapeutic advance. Etanercept is a soluble recombinant TNF receptor fusion protein in this vain. Areas covered: The aim of this review is to summarize the current published data concerning the efficacy and tolerance of etanercept in axial spondyloarthrits. The authors performed a systematic review on PubMed, using 'etanercept' and 'spondyloarthritis', 'axial spondyloarthritis' or 'ankylosing spondylitis' keywords...
September 2017: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/28662723/hla-b27-antigen-in-middle-eastern-and-arab-countries-systematic-review-of-the-strength-of-association-with-axial-spondyloarthritis-and-methodological-gaps
#16
Nelly Raymond Ziade
BACKGROUND: Axial spondyloarthritis (AxSpA) is a relatively frequent and debilitating disease, with a prevalence ranging from 0.1 to 2% in the Caucasian population. Current Assessment of Spondyloarthritis International Society (ASAS) classification criteria of AxSpA rely either on sacroiliitis on imaging plus one SpA feature or positive HLAB27 antigen plus two SpA features, in a patient with chronic low back pain and age at onset of less than 45 years. Therefore, HLA-B27 is a central feature in SpA classification and plays a pivotal role in referral strategies and early diagnosis...
June 29, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28612240/clinical-characteristics-of-peripheral-spondyloarthritis-without-psoriasis-inflammatory-enteropathy-or-preceding-infection-from-a-single-rheumatology-clinic-in-northern-india
#17
Anand Narayan Malaviya, Neha Agrawal, Nilesh Sahebrao Patil
The objective of this study was to characterise the peripheral arthritis of spondyloarthritis (pSpA) excluding psoriatic-, inflammatory enteropathy-related, post-infectious reactive-SpA and arthritis associated with axial SpA/ankylosing spondylitis (axSpA/AS). Patients presenting with the clinical features of the broad spectrum of SpA were screened for the presence of peripheral arthritis using the Assessment of SpondyloArthritis International Society (ASAS) criteria. The other conditions that could cause pSpA, e...
June 13, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28593426/-spondyloarthritides
#18
M Rudwaleit
Spondyloarthritides (SpA) are inflammatory rheumatic diseases affecting the axial skeleton, peripheral joints and entheses, and also manifest at extraskeletal sites. According to the more recently introduced nomenclature, predominant axial SpA is distinguished from predominant peripheral SpA. Axial SpA is further divided into radiographic and nonradiographic axial SpA. Genetic factors are relevant, with HLA-B27 being most important. The interleukin 23/17 pathway seems to be relevant and points towards new therapeutic targets...
July 2017: Der Internist
https://www.readbyqxmd.com/read/28569568/performance-of-the-classification-criteria-in-patients-with-late-onset-axial-spondyloarthritis
#19
Louise T Bendahan, Natália P Machado, Jamille G Mendes, Thauana L Oliveira, Marcelo M Pinheiro
AIM: To evaluate the performance of four different classification criteria for spondyloarthritis (SpA) in patients with late-onset symptoms and to compare the clinical, laboratory and radiographic outcomes among the patients with symptoms before and after 45 years of age. PATIENTS AND METHODS: A total of 329 patients with SpA were enrolled in this prospective cohort. Patients with psoriatic arthritis, reactive arthritis, colitis associated arthritis and peripheral or undifferentiated SpA were excluded...
June 1, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28569222/is-the-current-asas-expert-definition-of-a-positive-family-history-useful-in-identifying-axial-spondyloarthritis-results-from-the-space-and-desir-cohorts
#20
Zineb Ez-Zaitouni, Andrea Hilkens, Laure Gossec, Inger Jorid Berg, Robert Landewé, Roberta Ramonda, Maxime Dougados, Désirée van der Heijde, Floris van Gaalen
BACKGROUND: The Assessment of SpondyloArthritis international Society (ASAS) definition of a positive family history (PFH) of spondyloarthritis (SpA) includes the following diseases in first- or second-degree relatives: ankylosing spondylitis (AS), acute anterior uveitis (AAU), reactive arthritis (ReA), inflammatory bowel disease (IBD), and psoriasis. However, it is not known if a PFH for each of these diseases contributes to making a diagnosis of axSpA, sacroiliitis on imaging, or fulfilling the ASAS criteria in patients presenting with chronic back pain (CBP)...
May 31, 2017: Arthritis Research & Therapy
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