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Axial SpA

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https://www.readbyqxmd.com/read/29338498/from-clinical-remission-to-residual-disease-activity-in-spondyloarthritis-and-its-potential-treatment-implications
#1
Fabio Massimo Perrotta, Antonia De Socio, Silvia Scriffignano, Ennio Lubrano
Remission or low disease activity should be the target of therapy in spondyloarthritis (SpA). Due to the complexity of the disease, several composite indices that assess all disease domains were proposed to define a status of low disease activity/remission in both axial and peripheral SpA. With the introduction, in the past years, of effective biologic and targeted synthetic treatments aimed at inhibiting key cytokines and intracellular pathways, the goal of clinical remission has become an achievable target in these conditions...
January 17, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29299630/stability-of-fatigue-pain-patient-global-assessment-and-the-bath-ankylosing-spondylitis-functional-index-basfi-in-spondyloarthropathy-patients-with-stable-disease-according-to-the-bath-ankylosing-spondylitis-disease-activity-index-basdai
#2
Ole Rintek Madsen
The study objective was to examine natural variation of the patient-reported outcome measures fatigue, pain, patient global assessment (PaGl) and the Bath Ankylosing Spondylitis Functional Index (BASFI) in patients with stable axial spondyloarthropathy (ax-SpA) defined on the basis of the Bath Spondylitis Ankylosing Disease Activity Index (BASDAI). 107 TNF-inhibitor treated stable ax-SpA patients were identified in the Danish rheumatology registry (DANBIO). According to the Assessment of SpondyloArthritis international Society (ASAS) response criteria, stable disease was defined as a change in BASDAI < 20 between two consecutive visits...
January 3, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29290311/prevalence-and-risk-factors-for-osteoporosis-and-fractures-in-axial-spondyloarthritis-a-systematic-review-and-meta-analysis
#3
Julio Ramírez, Juan Carlos Nieto-González, Rafael Curbelo Rodríguez, Santos Castañeda, Loreto Carmona
OBJECTIVES: To describe the prevalence of osteoporosis, the prevalence and incidence of fractures, and the frequency of risk factors for low bone mineral density (BMD) in axial spondyloarthritis (Ax-SpA). METHODS: A systematic review and meta-analysis of observational studies was conducted. Medline, Embase, and Cochrane Library databases were searched with a sensitive strategy. Large cross-sectional and longitudinal studies published in the last 10 years (January 2006-2016) with representative samples of patients with Ax-SpA estimating the frequency of osteoporosis, risk factors or fractures were selected...
December 7, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29246242/the-use-of-the-tyrosine-kinase-inhibitor-nilotinib-in-spondyloarthritis-does-targeting-inflammatory-pathways-with-a-treatment-lead-to-vascular-toxicity
#4
REVIEW
Loukman Omarjee, Vincent Jaquinandi, Guillaume Mahe
Spondylarthritis (SpA) is an inflammatory rheumatic disease associated with increased incidence of major adverse cardiovascular events (MACEs). Recently, Paramarta et al. proposed the use of the tyrosine kinase inhibitor Nilotinib in Spondyloarthritis to target certain inflammatory pathways. However, Nilotinib, which is highly effective for the treatment of patients with chronic myeloid leukaemia (CML), is also associated with an increased risk of MACEs. The authors suggest that Nilotinib may be effective in peripheral SpA by modulating inflammation, but not in axial SpA...
December 15, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29222349/inequity-in-biological-dmard-prescription-for-spondyloarthritis-across-the-globe-results-from-the-asas-comospa-study
#5
Elena Nikiphorou, Désirée van der Heijde, Sam Norton, Robert Bm Landewé, Anna Molto, Maxime Dougados, Filip E Van den Bosch, Sofia Ramiro
OBJECTIVES: The value of biological disease-modifying antirheumatic drugs (bDMARDs) in spondyloarthritis (SpA) is well recognised, but global access to these treatments can be limited due to high costs and other factors. This study explores country variation in the use of bDMARDs in SpA in relation to country-level socioeconomic factors. METHODS: Patients fulfilling the Assessment in SpondyloArthritis International Society (ASAS) SpA criteria in the multinational, cross-sectional ASAS Comorbidities in Spondyloarthritis study were studied...
December 8, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29185966/the-prevalence-and-clinical-effect-of-immunogenicity-of-tnf-%C3%AE-blockers-in-patients-with-axial-spondyloarthritis
#6
Gil Bornstein, Merav Lidar, Pnina Langevitz, Alexander Fardman, Ilan Ben-Zvi, Chagai Grossman
OBJECTIVES: To evaluate the prevalence of immunogenicity of TNF-α blockers in axial spondyloarthritis (SpA) patients and to assess the effect of immunogenicity on drug levels and clinical response. METHPDS: Patients with axial SpA treated with either infliximab (INF), adalimumab (ADA) or etanercept (ETN) were recruited to our observational cross-sectional study. Demographic and clinical data were collected and disease activity scores were assessed. Drug trough levels and anti-drug antibodies were measured in serum samples and collected before the next administration...
November 28, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29155961/disease-activity-decrease-is-associated-with-improvement-in-work-productivity-over-1-year-in-early-axial-spondyloarthritis-spondyloarthritis-caught-early-cohort
#7
Miranda van Lunteren, Zineb Ez-Zaitouni, Camilla Fongen, Robert Landewé, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen
Objectives: To assess if a change in disease activity is associated with a change in work productivity loss (WPL) over 1 year in early axial SpA (axSpA) patients. Methods: Baseline and 1 year data of axSpA patients in the SPondyloArthritis Caught Early cohort were analysed. Linear regression models were built explaining the change in the Ankylosing Spondylitis Disease Activity Score (ASDAS) over time by the change in absenteeism, presenteeism, WPL and activity impairment over time...
October 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/29125891/profiling-response-to-tnf-inhibitor-treatment-in-axial-spondyloarthritis
#8
Mansour Alazmi, Ismail Sari, Bharath Krishnan, Robert D Inman, Nigil Haroon
OBJECTIVES: Lack of response to TNF inhibitory (TNFi) agents is not uncommon, encountered during the treatment of axial spondyloarthritis (AxSpA) patients and can be classified as primary (PLR) or secondary (SLR) lack of response. The primary aim of this study was to evaluate factors associated with TNFi failure types and their characteristics in AxSpA. METHODS: Adult AxSpA patients who were TNFi naive at the time of baseline evaluation and started on their first biologics for active axial disease were identified...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29119479/utility-of-ct-imaging-in-differentiating-sacroiliitis-associated-with-spondyloarthritis-from-gouty-sacroiliitis-a-retrospective-study
#9
Jyoti Panwar, Pulukool Sandhya, Madhavi Kandagaddala, Aswin Nair, Visalakshi Jeyaseelan, Debashish Danda
Sacroiliitis is one of the criteria for classification as spondyloarthritis (SpA), though not unique to SpA. Other conditions including gout may be erroneously diagnosed as SpA due to sacroiliitis. The objective was to identify specific CT findings in sacroiliitis associated with SpA and gout. In this retrospective study, CT images of patients with sacroiliitis and clinical diagnosis of gout or SpA from 2010 to 2015 were independently reviewed by two radiologists, blinded to diagnosis. Axial and coronal oblique images were analyzed for characteristics of erosions...
November 8, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29116386/clinical-and-ultrasonographic-enthesopathy-in-inflammatory-rheumatic-diseases-is-masei-or-only-calcaneal-enthesitis-sufficient
#10
Ekrem Süleyman, Kemal Nas, Halil Harman, Nedim Kaban
AIM: We aimed at investigating the ultrasonographic (US) and clinical prevalence of enthesopathy in patients with rheumatoid arthritis (RA), and axial spondyloarthropathy (SpA), as well as the correlation between this condition and disease activity, along with the quality of life. METHODS: Included in the study were 30 axial SpA, 21 patients with RA, and 25 healthy cases. Bath Anklylosing Spondylitis Disease Activity Index (BASDAI), Ankylosing Spondylitis Quality of Life (ASQoL), Disease activity index  28 (DAS28), and Health Assessment Questionnaire (HAQ) were used for clinical evaluation, and enthesal pain was evaluated by VAS, whereas enthesitis US evaluation was performed by using the MAdrid Sonographic Enthesitis Index (MASEI)...
November 7, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29112187/number-of-circulating-non-classical-cd14-cd16-monocytes-negatively-correlates-with-das28-and-swollen-joints-count-in-peripheral-spondyloarthritis-patients
#11
Zofia Guła, Małgorzata Stec, Magdalena Rutkowska-Zapała, Marzena Lenart, Mariusz Korkosz, Jerzy Gąsowski, Jarosław Baran, Monika Baj-Krzyworzeka, Rafał Szatanek, Jarosław Czyż, Maciej Siedlar
INTRODUCTION    Different clinical course and pattern of skeletal involvement in peripheral (per) and axial (ax) spondyloarthritis (SpA) suggests distinct pathophysiology of these two phenotypic manifestations of SpA. Monocytes, as a part of innate immune system, seem to play an important role in the pathogenesis of SpA, but exact inflammatory pathways remain to be elucidated. Regulatory T lymphocytes (Treg) and Th17 lymphocytes are also known to influence pro- and anti-inflammatory reactions. OBJECTIVES    The aim of our study was to compare absolute numbers of monocyte subpopulations, Treg and Th17 lymphocytes with clinical measures of disease activity in perSpA and axSpA...
November 7, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/29093157/sacroiliac-joint-magnetic-resonance-imaging-in-asymptomatic-patients-with-recurrent-acute-anterior-uveitis-a-proof-of-concept-study
#12
Thauana L Oliveira, Walter P Maksymowych, Robert G W Lambert, Cristina Muccioli, Artur R C Fernandes, Marcelo M Pinheiro
OBJECTIVE: Our aim was to quantify bone marrow edema (BME) and/or structural lesions in the sacroiliac joints (SIJ) of patients with recurrent acute anterior uveitis (rAAU) with or without back pain, to evaluate the frequency of axial (axSpA) and peripheral spondyloarthritis (pSpA) and to establish which criterion for magnetic resonance imaging (MRI) positivity best reflected the global assessment of SIJ MRI. METHODS: A total of 50 patients with rAAU without prior rheumatologic diagnosis were included in our cross-sectional study, and these patients were compared to 21 healthy volunteers...
December 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29045716/fibromyalgia-is-not-axial-spondyloarthritis-towards-an-appropriate-use-of-the-asas-classification-criteria-for-axial-spa
#13
Martin Rudwaleit
No abstract text is available yet for this article.
October 17, 2017: Rheumatology
https://www.readbyqxmd.com/read/29043434/-spondyloarthritides
#14
M Rudwaleit
Spondyloarthritides (SpA) are inflammatory rheumatic diseases affecting the axial skeleton, peripheral joints and entheses, and also manifest at extraskeletal sites. According to the more recently introduced nomenclature, predominant axial SpA is distinguished from predominant peripheral SpA. Axial SpA is further divided into radiographic and nonradiographic axial SpA. Genetic factors are relevant, with HLA-B27 being most important. The interleukin 23/17 pathway seems to be relevant and points towards new therapeutic targets...
October 17, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29029331/the-clinical-utility-of-human-leucocyte-antigen-b27-in-axial-spondyloarthritis
#15
Chong Seng Edwin Lim, Raj Sengupta, Karl Gaffney
The association between HLA-B27 and AS was first established in the early 1970s. Since then, our understanding of this disease has changed, such that we now recognize AS to be the extreme of the clinical phenotype within a disease spectrum known as axial SpA (axSpA). Recent advances in therapeutic options have driven the need for earlier diagnosis and many screening strategies have been proposed to facilitate this. In parallel, our understanding of axSpA genetics, and especially the contribution of HLA-B27, has expanded...
September 25, 2017: Rheumatology
https://www.readbyqxmd.com/read/29018906/the-performance-of-classification-criteria-for-juvenile-spondyloarthropathies
#16
Amra Adrovic, Metin Sezen, Kenan Barut, Sezgin Sahin, Cengizhan Acikel, Erkan Demirkaya, Ozgur Kasapcopur
Juvenile spondyloarthropathies (JSpA) are a group of rheumatologic diseases with a disease onset before 16; characterized with enthesitis, lower extremity oligoarthritis, involvement of the axial skeleton and HLA B27 positivity. The diversity of classification criteria along with the phenotype heterogeneity makes the classification of JSpA challenging. The aim of our study was to evaluate the performance of the pre-determined and recently proposed classification criteria for JSpA. The study group consisted of 113 patients with JSpA and 150 patients with juvenile idiopathic arthritis (JIA)...
December 2017: Rheumatology International
https://www.readbyqxmd.com/read/28976332/bone-single-photon-emission-computed-tomography-in-the-detection-of-sacroiliitis-in-seronegative-spondyloarthritis-a-comparison-with-magnetic-resonance-imaging
#17
Theodoros Pipikos, Dimitrios Kassimos, George Angelidis, John Koutsikos
OBJECTIVE: Seronegative spondyloarthritis (SpA) is characterized by chronic inflammation affecting the axial skeleton, entheses and occasionally peripheral joints. The involvement of the sacroiliac joints, sacroiliitis, is considered as a pathognomonic radiographic finding. Magnetic resonance imaging (MRI) is the method of choice for its early detection. Bone scintigraphy (BS) is characterized by high sensitivity in the diagnosis of bone and articular diseases. Limited value of BS in the diagnosis of sacroiliitis may be attributed to the use of planar imaging...
October 3, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28955496/relationships-between-ultrasound-enthesitis-disease-activity-and-axial-radiographic-structural-changes-in-patients-with-early-spondyloarthritis-data-from-desir-cohort
#18
Adeline Ruyssen-Witrand, Bénédicte Jamard, Alain Cantagrel, Delphine Nigon, Damien Loeuille, Yannick Degboe, Arnaud Constantin
BACKGROUND: To search for association between ultrasound (US) enthesis abnormalities and disease activity, spine and sacro-iliac joints (SIJ) MRI inflammatory lesions and spine structural changes in a cohort of patients suspected for axial spondyloarthritis (SpA). METHODS: Patients: Of 708 patients included in the DESIR(Devenir des Spondyloarthrites Indifférenciées Récentes) cohort, 402 had an US enthesis assessment and were selected for this study. Imaging: Achilles, lateral epicondyles, superior patellar ligament, inferior patellar ligament entheses were systematically US scanned and abnormalities were summed in US structural and power Doppler (PDUS) scores...
2017: RMD Open
https://www.readbyqxmd.com/read/28937503/patient-burden-of-axial-spondyloarthritis
#19
Vibeke Strand, Jasvinder A Singh
Axial spondyloarthritis (AxSpA) is an inflammatory spondyloarthritis (SpA) that has significant impact on a patient's life. Symptoms, including fatigue, sleep problems, depression, and sexual dysfunction, can profoundly impact health-related quality of life (HRQoL) and limit work, leisure, and daily activities. Available therapies effectively manage pain and inflammation in early-stage disease, but patients often continue to experience impaired HRQoL. Thus, there remains a need for new therapies with novel mechanisms that can stop disease progression, potentially reverse damage caused by AxSpA and improve HRQoL in patients with AxSpA...
September 21, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28937474/patient-burden-of-axial-spondyloarthritis
#20
Vibeke Strand, Jasvinder A Singh
Axial spondyloarthritis (AxSpA) is an inflammatory spondyloarthritis (SpA) that has significant impact on a patient's life. Symptoms, including fatigue, sleep problems, depression, and sexual dysfunction, can profoundly impact health-related quality of life (HRQoL) and limit work, leisure, and daily activities. Available therapies effectively manage pain and inflammation in early-stage disease, but patients often continue to experience impaired HRQoL. Thus, there remains a need for new therapies with novel mechanisms that can stop disease progression, potentially reverse damage caused by AxSpA and improve HRQoL in patients with AxSpA...
October 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
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