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https://www.readbyqxmd.com/read/29786781/the-ejes-3d-tool-for-personalized-prescription-of-exercise-in-axial-spondyloarthritis-through-multimedia-animations-pilot-study
#1
Mariano Tomás Flórez, Raquel Almodóvar, Fernando García Pérez, Ana Belén Rodríguez Cambrón, Loreto Carmona, María Ángeles Pérez Manzanero, Juan Aboitiz Cantalapiedra, Ana Urruticoechea-Arana, Carlos J Rodríguez Lozano, Carmen Castro, Cristina Fernández-Carballido, Eugenio de Miguel, Eva Galíndez, José Luis Álvarez Vega, Juan Carlos Torre Alonso, Luis F Linares, Mireia Moreno, Victoria Navarro-Compán, Xavier Juanola, Pedro Zarco
To develop and evaluate a web application based on multimedia animations, combined with a training program, to improve the prescription of exercises in spondyloarthritis (SpA). After a review of exercises included in the main clinical trials and recommendations of international societies, a multidisciplinary team-rehabilitators, rheumatologists, physiotherapists, computer scientists and graphic designers-developed a web application for the prescription of exercises (EJES-3D). Once completed, this was presented to 12 pairs of rehabilitators-rheumatologists from the same hospital in a workshop...
May 21, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29767341/-spondyloarthritis
#2
REVIEW
U Syrbe, X Baraliakos
Spondyloarthritis (SpA) describes the group of inflammatory diseases characterized by inflammation within axial joints and/or peripheral arthritis, enthesitis, and dactylitis. Disease development is strongly determined by genes and particularly associated with the presence of HLA-B27. Transgenic expression in animal models leads to induction of a SpA-like disease, suggesting a direct effect of HLA-B27 on disease development. Genome-wide association studies in SpA patients have identified further associations between polymorphisms in genes with an immune function, in particular in genes controlling the interleukin (IL)-23/IL-17 signaling pathway...
May 16, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29754330/gender-differences-in-axial-spondyloarthritis-women-are-not-so-lucky
#3
REVIEW
T Rusman, R F van Vollenhoven, I E van der Horst-Bruinsma
PURPOSE OF REVIEW: Ankylosing spondylitis (AS) was historically seen as a predominantly male disease. However, more recent data showed a more homogenous sex prevalence. Unfortunately, in many studies in axial spondyloarthritis (axSpA), the number of women included is low and the analyses are often not stratified for gender distribution. The purpose of this review is to aggregate the existing data on gender differences in axSpA in order to increase the awareness that female axSpA patients are still under-recognized...
May 12, 2018: Current Rheumatology Reports
https://www.readbyqxmd.com/read/29751976/high-prevalence-of-hidradenitis-suppurativa-symptoms-in-axial-spondyloarthritis-patients-a-possible-new-extra-articular-manifestation
#4
Angelique Rondags, Suzanne Arends, Freke R Wink, Barbara Horváth, Anneke Spoorenberg
BACKGROUND: Spondyloarthritis (SpA), a chronic inflammatory, rheumatic disease, and hidradenitis suppurativa (HS), a chronic, debilitating, inflammatory skin disease, share several clinical and pathophysiological features, such as the association with inflammatory bowel disease and elevated cytokine levels IL-17 and TNF-α. Recently, SpA was reported to be more prevalent (2.3-28.2%) in patients with HS than in the general population. Conversely, the prevalence of HS in SpA is not exactly known...
March 20, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29745883/prevalence-and-characteristics-associated-with-dactylitis-in-patients-with-early-spondyloarthritis-results-from-the-esperanza-cohort
#5
Maria Isabel Tévar-Sánchez, Victoria Navarro-Compán, Juan J Aznar, Luis F Linares, Maria C Castro, Eugenio De Miguel
OBJECTIVES: Dactylitis is a typical feature of psoriatic arthritis. However, dactylitis was included as a spondyloarthritis (SpA) feature for both (axial and peripheral) of the ASAS classification criteria, but data about its prevalence are scarce, especially in patients with a recent onset of the disease. Our objective was to determine the prevalence and characteristics associated with dactylitis in patients with early SpA. METHODS: A baseline dataset from the ESPeranza cohort was used...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29745878/should-over-treatment-of-axial-spondyloarthritis-with-biologics-remain-a-concern-after-the-issue-of-the-new-asas-criteria-data-from-regisponserbio-spanish-register-of-biological-therapy-in-spondyloarthritides
#6
Mireia Moreno, Jordi Gratacós, Victoria Navarro-Compán, Eugenio de Miguel, Pilar Font, Teresa Clavaguera, Luis Francisco Linares, Beatriz Joven, Xavier Juanola
OBJECTIVES: To study whether disease status at treatment initiation has changed after the issue of the ASAS classification criteria. METHODS: REGISPONSERBIO registers patients with axial spondyloarthritis (axSpA) on biological treatment since 2013. It includes patients starting biological treatment (incident) or already on biological therapies (prevalent). Patients in both groups were compared in terms of: age at disease onset and at treatment start, disease duration, gender, HLA-B27, body mass index (BMI), BASDAI, BASFI, C-reactive protein, ESR, metrological data, ASQoL, WAPAI, extra-articular manifestations, comorbidities, radiological study, type of biological treatment and concomitant treatments...
May 8, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29743324/spondyloarthritis-in-the-democratic-republic-of-the-congo-a-prospective-hospital-based-study
#7
Pierrot Lebughe, Kurt de Vlam, Rene Westhovens, Jean-Marie Mbuyi-Muamba, Jean Jacques Malemba
OBJECTIVES: To determine the spectrum of spondyloarthritis (SpA) in outpatients with symptoms of rheumatism attending two rheumatology practices in the Democratic Republic of the Congo. DESIGN: A descriptive prospective multicentre outpatient study. SETTING: The present study analysed 6 months data (from 1 December 2012 till 31 May 2013). PARTICIPANTS: Nine hundred and eighty-four consecutive outpatients were studied...
May 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29740978/inflammatory-bowel-disease-and-acute-anterior-uveitis-but-not-psoriasis-are-associated-with-disease-duration-in-axial-spa-results-from-the-be-giant-and-aspect-cohort
#8
Gaëlle Varkas, Nathan Vastesaeger, Heleen Cypers, Roos Colman, Thomas Renson, Liesbet Van Praet, Philippe Carron, F Raeman, Mieke Devinck, Lieve Gyselbrecht, Luc Corluy, Yves Piette, Jan Lenaerts, Kristof Thevissen, Benedicte Vanneuville, Filip Van den Bosch, Dirk Elewaut
OBJECTIVE: To determine the link between extra-articular manifestations (EAMs) and baseline patient characteristics, and to define their potentially differential prognostic value in two large nation-wide and independent AxSpA cohorts with distinct recruitment periods. METHODS: The analyzed data originate from the (Be-)Giant cohort which includes consecutive patients with AxSpA since 2010, whereas ASPECT which includes information on consecutive patients with ankylosing spondylitis (AS) and probable AS between February 2004 and 2005...
May 9, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29702496/quantifying-the-genetic-risk-for-the-development-of-axial-spondyloarthropathy-could-this-become-a-diagnostic-tool
#9
Bryan P Wordsworth, Carla J Cohen, Matteo Vecellio
PURPOSE OF REVIEW: To assess the utility of recent genetic findings in ankylosing spondylitis (AS) and axial spondyloarthropathy (SpA) in relation to diagnostic testing, prognosis and responses to biologic treatment and the development of new therapies. RECENT FINDINGS: AS and other forms of SpA are polygenic with more than 100 genes contributing to disease susceptibility. The role of genes in determining the outcome of the disease and response to treatment is less clear...
April 26, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29686921/axial-spondyloarthritis-and-autosomal-dominant-polycystic-kidney-disease-in-two-siblings-a-rare-cooccurrence
#10
Ozan Volkan Yurdakul, Abdulkerim Furkan Tamer, Okan Küçükakkaş, Aylin Rezvani
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequently occurring hereditary kidney disease, and axial spondyloarthritis (SpA) is one of the most frequently occurring rheumatic diseases. Treatment-related decisions for axial SpA may pose a challenge in case of renal involvement. The authors describe two siblings with cooccurrence of these two diseases. The association of these two diseases is not well known. Practitioners should monitor renal function in SpA patients and take treatment-related decisions regarding renal involvement...
2018: Case Reports in Rheumatology
https://www.readbyqxmd.com/read/29681195/biologics-for-treating-axial-spondyloarthritis
#11
Alexis Jones, Coziana Ciurtin, Mediola Ismajli, Maria Leandro, Raj Sengupta, Pedro M Machado
Spondyloarthritis (SpA) encompasses a heterogeneous group of diseases sharing genetic, immunological, clinical and imaging features. Axial spondyloarthritis (axSpA) refers to a subgroup characterised predominately by inflammation of the axial skeleton with subsequent symptoms of chronic (often inflammatory) back pain and sacroiliitis. There is a strong association with the major histocompatibility complex (MHC) class I allele human leukocyte antigen (HLA) B27. In the last decade, there has been significant progress in earlier detection of the disease and the molecular mechanisms involved in its pathogenesis...
April 21, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29672808/anterior-chest-wall-in-axial-spondyloarthritis-imaging-interpretation-and-differential-diagnosis
#12
Winston J Rennie, Lennart Jans, Anne Grethe Jurik, Iwona Sudoł-Szopińska, Claudia Schueller-Weidekamm, Iris Eshed
Anterior chest wall (ACW) inflammation is not an uncommon finding in patients with axial spondyloarthritis (ax-SpA) and reportedly occurs in 26% of these patients. Radiologists may only be familiar with spinal and peripheral joint imaging, possibly due to the inherent challenges of ACW imaging on some cross-sectional imaging modalities. Knowledge of relevant joint anatomy and the location of sites of inflammation allows the interpreting radiologist to better plan appropriate imaging tests and imaging planes...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29664756/mri-in-spondyloarthritis-when-and-how
#13
Georg Kröber, Ulrich Weber
PURPOSE OF REVIEW: To summarize recent advances and challenges of using MRI toward early recognition of axial spondyloarthritis (SpA). RECENT FINDINGS: Low-grade bone marrow edema (BME) on sacroiliac joint (SIJ) MRI is nonspecific and may be misleading in recognition of axial SpA. Structural features on SIJ MRI along with BME may not only facilitate recognition of early disease, but also enhance specificity. Structural lesions on MRI and low-dose computed tomography are highly concordant, adding to criterion validity of SIJ MRI...
April 13, 2018: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29652659/efficiency-of-dose-reduction-strategy-of-etanercept-in-patients-with-axial-spondyloarthritis
#14
Fan Lian, Jun Zhou, Yu Wang, Dongying Chen, Hanshi Xu, Liuqin Liang
OBJECTIVES: To evaluate the efficacy of different tapering or discontinuation strategies of etanercept in a cohort of axial spondyloarthritis from South China. METHODS: We performed a retrospective cohort study. Axial SpA patients who achieved clinical remission for at least 6 months after receiving a standard dose of etanercept therapy were enrolled. Different tapering or discontinuation strategies were compared. RESULTS: Altogether, 258 cases were enrolled...
April 13, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29606666/comparative-analysis-and-predictors-of-10-year-tumor-necrosis-factor-inhibitors-drug-survival-in-patients-with-spondyloarthritis-first-year-response-predicts-longterm-drug-persistence
#15
Irini D Flouri, Theodora E Markatseli, Kyriaki A Boki, Ioannis Papadopoulos, Fotini N Skopouli, Paraskevi V Voulgari, Loukas Settas, Dimitrios Zisopoulos, Alexios Iliopoulos, Pierre Geborek, Alexandros A Drosos, Dimitrios T Boumpas, Prodromos Sidiropoulos
OBJECTIVE: To evaluate the 10-year drug survival of the first tumor necrosis factor inhibitor (TNFi) administered to patients with spondyloarthritis (SpA) overall and comparatively between SpA subsets, and to identify predictors of drug retention. METHODS: Patients with SpA in the Hellenic Registry of Biologic Therapies, a prospective multicenter observational cohort, starting their first TNFi between 2004-2014 were analyzed. Kaplan-Meier curves and Cox regression models were used...
April 1, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29595277/-the-role-of-magnetic-resonance-imaging-in-diagnostics-of-axial-spondyloarthritis
#16
Martin Žlnay
Axial spondyloarthritis (SpA) is a chronic inflammatory rheumatic disorder that primary affects axial skeleton. It comprises wide spectrum of patients with immune mediated spine inflammation, from early, so called non-radiographic axial spondyloarthritis to clinically evident ankylosing spondylitis. Conventional radiography is still the cornerstone of diagnosis, evaluation and classification of SpA. However, it has limitations in early disease, because it can only depict the consequences of inflammation for its inability to visualize soft tissue abnormalities within bone marrow...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29584927/impact-of-replacing-radiographic-sacroiliitis-by-magnetic-resonance-imaging-structural-lesions-on-the-classification-of-patients-with-axial-spondyloarthritis
#17
Pauline A Bakker, Rosaline van den Berg, Manouk de Hooge, Miranda van Lunteren, Zineb Ez-Zaitouni, Karen M Fagerli, Robert Landewé, Maikel van Oosterhout, Roberta Ramonda, Monique Reijnierse, Floris A van Gaalen, Désirée van der Heijde
Objectives: To investigate in patients with chronic back pain of a short duration, the utility of adding structural MRI lesions of the SI joints to the imaging criterion of the Assessment of SpondyloArthritis International Society (ASAS) axial SpA (axSpA) criteria and the utility of replacement of radiographic sacroiliitis by structural MRI lesions. Methods: MRI STIR (inflammation, MRI-SI), MRI T1-weighted images (structural lesions, MRI-SI-s) and radiographs of the SI joints of patients in the SPondyloArthritis Caught Early-cohort (chronic back pain: ⩾3 months, ⩽2 years; onset <45 years) were scored by two well-calibrated readers...
March 23, 2018: Rheumatology
https://www.readbyqxmd.com/read/29534215/associations-between-trabecular-bone-score-and-vertebral-fractures-in-patients-with-axial-spondyloarthritis
#18
Kwi Young Kang, In Je Kim, Sung-Hwan Park, Yeon Sik Hong
Objectives: To compare trabecular bone scores (TBS) between axial SpA (axSpA) patients with and without vertebral fractures and investigate associations between TBS and vertebral fractures. Methods: Two hundred and fifty-five patients fulfilling the imaging arm of the Assessment of SpondyloArthritis International Society axSpA criteria were enrolled. TBS and BMD were assessed using dual-energy X-ray absorptiometry. Vertebral fracture of the thoracic and lumbar spine was defined according to the Genant criteria...
March 9, 2018: Rheumatology
https://www.readbyqxmd.com/read/29506017/effectiveness-of-a-referral-program-for-rheumatoid-arthritis-and-axial-spondyloarthritis-diagnosis-at-primary-care-centers-in-portugal-siara-study
#19
João Eurico Fonseca, José António Pereira da Silva, Miguel Bernardes, Rui Cernadas, José Canas da Silva, Lúcia Costa, Taciana Videira, Luís C Miranda, Anabela Barcelos, Pedro A Laires, Raquel Dezerto, Marília D Pereira, Filomena Vidal, Esmeralda Cunha, Ana Morais, Carla Martins, Rui Mesquita
OBJECTIVES: Early diagnosis and treatment of Rheumatoid Arthritis (RA) and axial Spondylarthritis (axial SpA) can limit the impact of disease outcomes. This study evaluated the effectiveness of a referral program on the identification of patients with RA and axial SpA. METHODS: This was an observational, prospective, randomized (by clusters) study conducted in Portugal to evaluate the impact of the implementation of a set of referral support actions (RSA). The study was divided in two sub-studies, the RA sub-study and the axial SpA sub-study...
January 2018: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/29490705/anti-cd74-antibodies-have-no-diagnostic-value-in-early-axial-spondyloarthritis-data-from-the-spondyloarthritis-caught-early-space-cohort
#20
Janneke J de Winter, Marleen G van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen, Torsten Witte, Dominique L Baeten
BACKGROUND: Anti-CD74 IgG antibodies are reported to be elevated in patients with axial spondyloarthritis (axSpA). This study assessed the diagnostic value of anti-CD74 antibodies in patients with early axSpA. METHODS: Anti-CD74 IgG and IgA antibodies were first measured in an exploratory cohort of patients with radiographic axSpA (138 patients with ankylosing spondyloarthritis (AS)) and 57 healthy controls and then were measured in patients with early axSpA (n = 274) and with non-SpA chronic back pain (CBP) (n = 319), participating in the spondyloarthritis caught early (SPACE) prospective cohort study of patients under 45 years old with early back pain (for ≥ 3 months, but ≤ 2 years)...
March 1, 2018: Arthritis Research & Therapy
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