keyword
https://read.qxmd.com/read/38511247/the-role-of-ixekizumab-in-the-treatment-of-nonradiographic-axial-spondyloarthritis
#1
REVIEW
Bora Nam, Tae-Hwan Kim
Nonradiographic axial spondyloarthritis (nr-axSpA) is a subtype of SpA with undeveloped definite radiographic sacroiliitis. Tumor necrosis factor inhibitors have demonstrated effectiveness in nr-axSpA patients who do not respond to first-line therapy. More recently, accumulated data from genetic, experimental, and clinical studies revealed that IL-17 is a key player in the pathogenesis of SpA, leading to development of new biologics directly inhibiting IL-17. Among them, ixekizumab is a high-affinity monoclonal antibody that selectively targets IL-17A and has exhibited significant efficacy and acceptable safety profiles in the treatment of nr-axSpA...
March 21, 2024: Immunotherapy
https://read.qxmd.com/read/38509033/clinical-laboratory-and-imaging-features-between-men-and-women-with-axial-spondyloarthritis-in-a-specialized-center-in-argentina
#2
JOURNAL ARTICLE
Rodrigo Garcia-Salinas, Gisele Reyes Jara, Juan Arguello, Santiago Ruta, Felicia Almada, Dario Aguerre
OBJECTIVES: The aims were to estimate the frequency of axial spondyloarthritis (axSpA) in women and to analyze the clinical, laboratory, and imaging differences with respect to men at the time of diagnosis. METHODS: Consecutive patients older than 18 years with a diagnosis of axSpA were included between 2017 and 2022 admitted to the "Reuma-check" SpA program. At baseline, all patients underwent clinical assessment, laboratory tests including C-reactive protein and human leukocyte antigen B27, and imaging (plain radiography [x-ray] and magnetic resonance imaging of sacroiliac joints, and ultrasound of heel entheses)...
March 21, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://read.qxmd.com/read/38479822/flare-prediction-after-tapering-the-dose-of-tumour-necrosis-factor-inhibitors-in-patients-with-axial-spondyloarthritis-a-nationwide-cohort-study
#3
JOURNAL ARTICLE
Jina Yeo, Ju Yeon Kim, Jin Kyun Park, Kichul Shin, Eun Young Lee, Tae-Hwan Kim, Jun Won Park
OBJECTIVES: To develop a model for predicting flares after tapering the dose of tumour necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA). METHODS: Data were obtained from the Korean College of Rheumatology Biologics and Targeted Therapy Registry. In total, 526 patients who received the standard-dose TNFi for at least 1 year and tapered their dose were included in the derivation cohort. The main outcome was a flare occurrence defined as an Ankylosing Spondylitis Disease Activity Score with C-reactive protein (ASDAS-CRP) score of ≥ 2...
March 13, 2024: Rheumatology
https://read.qxmd.com/read/38479110/clinical-and-imaging-outcomes-of-different-phenotypes-of-axial-spondyloarthritis-5-year-analysis-of-the-desir-cohort
#4
JOURNAL ARTICLE
Alexandre Sepriano, Sofia Ramiro, Désirée van der Heijde, Anna Moltó, Cécile Gaujoux-Viala, Maxime Dougados, Robert Landewé
OBJECTIVES: To compare the long-term outcomes of three phenotypes of axial SpA (axSpA). METHODS: Patients with a clinical diagnosis of axSpA from the DESIR cohort were grouped into three phenotypes at baseline: 'Pure axSpA' ('Axial'), 'axSpA with peripheral signs' ('IBP+Peripheral') and 'axSpA at risk' ('At risk') by latent class analysis. Clinical and imaging data were collected up to 5 years. Clinical outcomes, measured in each visit, included disability (BASFI) and quality of life (QoL; SF36)...
March 2, 2024: Seminars in Arthritis and Rheumatism
https://read.qxmd.com/read/38443281/the-bright-easter-bunny-sign-a-useful-aide-memoire-on-mri-for-costotransverse-joint-inflammation-in-axial-spondyloarthritis
#5
JOURNAL ARTICLE
A Nauzer, T Bansal, A Vibhakar, A Shah, W J Rennie
AIM: To assess the significance of the "bright Easter bunny" sign on magnetic resonance imaging (MRI) to indicate inflammatory costotransverse joint (CtJ) lesions to diagnose axial spondyloarthritis (ax-SpA). MATERIALS AND METHODS: Consecutive cases of patients with ax-SpA from a specialist rheumatology clinic were analysed retrospectively over two cohorts, between 2012-2014 and 2018-2020, to determine newly diagnosed patients under the Assessment of SpondyloArthritis international Society (ASAS) criteria...
February 12, 2024: Clinical Radiology
https://read.qxmd.com/read/38443140/power-doppler-signal-at-the-enthesis-and-bone-erosions-are-the-most-discriminative-omeract-ultrasound-lesions-for-spa-results-from-the-deus-defining-enthesitis-on-ultrasound-in-spondyloarthritis-multicentre-study
#6
JOURNAL ARTICLE
Andrea Di Matteo, Gianluca Smerilli, Stefano Di Donato, An Ran Liu, Andrea Becciolini, Federica Camarda, Tomas Cazenave, Edoardo Cipolletta, Davide Corradini, Juan José de Agustín, Giulia Maria Destro Castaniti, Eleonora Di Donato, Luca Di Geso, Emine Duran, Bayram Farisogullari, Marco Fornaro, Francesca Francioso, Pamela Giorgis, Amelia Granel, Cristina Hernández-Díaz, Rudolf Horvath, Jana Hurnakova, Diogo Jesus, Omer Karadag, Ling Li, Josefina Marin, María Victoria Martire, Xabier Michelena, Erica Moscioni, Laura Muntean, Matteo Piga, Marcos Rosemffet, João Rovisco, Didem Sahin, Fausto Salaffi, Liliana Saraiva, Crescenzio Scioscia, Maria-Magdalena Tamas, Shun Tanimura, Aliki Venetsanopoulou, Lucio Ventura-Rios, Orlando Villota, Catalina Villota-Eraso, Paraskevi V Voulgari, Gentiana Vukatana, Johana Zacariaz Hereter, Helena Marzo-Ortega, Walter Grassi, Emilio Filippucci
OBJECTIVES: To assess, in spondyloarthritis (SpA), the discriminative value of the Outcome Measures in Rheumatology (OMERACT) ultrasound lesions of enthesitis and their associations with clinical features in this population. METHODS: In this multicentre study involving 20 rheumatology centres, clinical and ultrasound examinations of the lower limb large entheses were performed in 413 patients with SpA (axial SpA and psoriatic arthritis) and 282 disease controls (osteoarthritis and fibromyalgia)...
March 5, 2024: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/38435412/real-world-experience-of-il-17ai-drug-survival-in-a-large-cohort-of-axial-spondyloarthritis-and-psoriatic-arthritis
#7
JOURNAL ARTICLE
Jake Weddell, Naw Ra Aung Din, Stephanie R Harrison, Xabier Michelena, Dennis McGonagle, Andrew Barr, Claire Vandevelde, Jane Freeston, Helena Marzo-Ortega
OBJECTIVE: The aim was to assess the use and drug survival of IL-17Ai in a real-world cohort of axial SpA (axSpA) and PsA patients. METHODS: Patients ever commenced on an IL-17Ai (secukinumab or ixekizumab) for axSpA or PsA at the Leeds Specialist Spondyloarthritis Service were identified. Demographics, IL-17Ai treatment length and reason for cessation were collected. Drug survival data were plotted as a Kaplan-Meier curve, with log rank test of median survival compared between axSpA and PsA...
2024: Rheumatology Advances in Practice
https://read.qxmd.com/read/38405075/male-spondyloarthritis-patients-and-those-with-longer-disease-duration-have-less-severe-disc-degeneration-propensity-score-matched-comparison
#8
JOURNAL ARTICLE
Samuel Tin Yan Cheung, Helen Hoi Lun Tsang, Prudence Wing Hang Cheung, Jason Pui Yin Cheung
OBJECTIVE: Using whole spine sagittal T2 MRI, we aimed to compare the severity and prevalence of disc degeneration (DD) in axial SpA patients vs the general population and to determine any association between spinal inflammation, structural changes, mobility and DD among SpA patients. METHODS: Two prospectively collected cohorts of SpA patients ( n  = 411) and the general population ( n  = 2007) were recruited. Eventually, 967 participants from the populational cohort and 304 participants from the SpA cohort were analysed...
2024: Rheumatology Advances in Practice
https://read.qxmd.com/read/38380226/clinical-and-imaging-findings-in-enteropathic-spondyloarthritis-with-special-emphasize-in-diagnostic-delay-a-cross-sectional-study
#9
JOURNAL ARTICLE
Paola Conigliaro, Arianna D'Antonio, Andrea Wlderk, Federico Sabuzi, Mario Ferraioli, Leonardo Sichi, Valerio Da Ros, Livia Biancone, Alberto Bergamini, Maria Sole Chimenti
BACKGROUND: Enteropathic spondyloarthritides (eSpAs) are chronic inflammatory joint diseases associated with inflammatory bowel disease (IBD). Limited data are available on the prevalence since arthritis in IBD patients may be underestimated because medications may hide disease activity with a possible diagnostic delay. OBJECTIVES: We aimed to evaluate diagnostic delay in eSpA and explore associated demographic, clinical, and radiographic characteristics. DESIGN: Single-centre cross-sectional study conducted on consecutive out-patients referred to the combined Gi-Rhe clinic (November 2018-October 2019)...
2024: Therapeutic Advances in Chronic Disease
https://read.qxmd.com/read/38368549/neutrophile-to-lymphocyte-and-platelet-to-lymphocyte-ratios-predict-clinical-response-to-bdmard-in-na%C3%A3-ve-spondylarthritis-patients
#10
JOURNAL ARTICLE
Frederico Rajão Martins, Miguel Bernardes, Graça Sequeira, Lúcia Costa, Pedro David Carvalho
Objective We aim to study association between neutrophile to lymphocyte (NLR) and platelet to lymphocyte (PLR) ratios and disease activity, and their value to predict bDMARD response. Methods A set of spondylarthritis (SpA) patients under bDMARD registered in the Reuma.pt registry was studied. Sociodemographic, clinical and laboratorial variables were assessed on bDMARD initiation, 6, 12, 18 and 24 months (M) thereafter. Univariable and multivariable generalized estimation equations models assessed associations with disease activity...
January 15, 2024: ARP Rheumatol
https://read.qxmd.com/read/38359938/erosions-on-t1-weighted-mri-vs-radiography-of-sacroiliac-joints-in-recent-onset-axial-spa-2-year-data-embark-trial-and-desir-cohort
#11
JOURNAL ARTICLE
Walter P Maksymowych, Pascal Claudepierre, Manouk de Hooge, Robert G Lambert, Robert Landewé, Anna Molto, Désirée van der Heijde, Jack F Bukowski, Heather Jones, Ron Pedersen, Annette Szumski, Bonnie Vlahos, Maxime Dougados
OBJECTIVE: To (1) compare the capacity to detect sacroiliac joint (SIJ) erosions and baseline-to-Week-104 change in erosions between magnetic resonance imaging (MRI) and radiographs in recent-onset axial spondyloarthritis (axSpA); (2) compare treatment discriminatory capacities of MRI and radiographic scores for erosion detection in patients receiving etanercept in the EMBARK trial vs controls in the DESIR cohort. METHODS: Anonymized SIJ MRI and radiographs were assessed at patient and joint surface levels...
February 15, 2024: Journal of Rheumatology
https://read.qxmd.com/read/38323351/ultrasonographic-evaluation-of-nail-involvement-in-patients-with-axial-spondyloarthritis
#12
JOURNAL ARTICLE
Bilal Kulaksız, Deniz Palamar, Tugce Ozekli Misirlioglu, Kenan Akgun, Rana Terlemez
OBJECTIVES: This study aimed to evaluate the nail units of patients with axial spondyloarthritis (ax-SpA) using ultrasound and to identify any subclinical changes. We also aimed to examine the relationship between clinical enthesitis scores and nail involvement in patients with ax-SpA. METHODS: The study included 40 patients with ax-Spa, 40 patients with psoriatic arthritis (PsA), and 40 healthy controls. The thickness of the nail plates, morphological changes, the thickness of the proximal nail units, the thickness of the nail beds, and power Doppler signal intensities were evaluated and compared...
February 7, 2024: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://read.qxmd.com/read/38314595/insight-into-the-epidemiology-of-the-adult-onset-systemic-autoimmune-rheumatic-diseases-in-egypt-a-descriptive-study-of-8690-patients
#13
JOURNAL ARTICLE
Doaa H S Attia, Ahmed Y Ismaeel, Eman R Mohamed, Nermeen H A Moneim, Yossra A Suliman, Rasha A Abdel Noor
BACKGROUND/OBJECTIVE: Although systemic autoimmune rheumatic diseases (SARDs) seem to be ubiquitous, Africa and the Middle East seem to be a remarkable exception with scarcity of data compared with the developed countries. Furthermore, most of the studies addressed a particular disease. This work aimed to shed light on the relative frequency and epidemiology of the different adult-onset SARDs in Egypt. METHODS: This is a retrospective hospital-based study including six university hospitals providing free health care services: Cairo, Alexandria, Tanta, Ismailia, Beni-Suef and Assiut University Hospitals...
January 16, 2024: Current Rheumatology Reviews
https://read.qxmd.com/read/38305346/performance-of-clinical-laboratory-and-imaging-features-for-diagnosing-spondyloarthritis-a-systematic-literature-review-and-meta-analysis
#14
JOURNAL ARTICLE
Ana Bento da Silva, Maria Helena Lourenço, Sofia Ramiro, Louise Falzon, Jaime Cunha-Branco, Désirée van der Heijde, Robert Landewé, Alexandre Sepriano
OBJECTIVE: The Berlin algorithm was developed to help diagnosing axial spondyloarthritis (axSpA), but new studies suggest some features typical of SpA are less specific than previously assumed. Furthermore, evidence is lacking for other SpA subtypes (e.g. peripheral SpA). We aimed to review the evidence on the performance of SpA features for diagnosing each SpA subtype. METHODS: Systematic literature review of studies reporting the diagnostic performance of ≥ 1 SpA feature in patients with suspected SpA...
February 1, 2024: Rheumatology
https://read.qxmd.com/read/38287559/mri-for-axial-spa-diagnosis-disease-activity-assessment-and-recent-advances
#15
REVIEW
Shirley Chiu Wai Chan, Ho Yin Chung
Magnetic resonance imaging (MRI) is a sensitive imaging modality to detect early inflammatory changes in axial spondyloarthritis (SpA). Over a decade has passed since the inclusion of MRI assessment in the 2009 Assessment of SpondyloArthritis International Society (ASAS) classification criteria for axial SpA. Evidence and clinical experience of MRI in axial SpA have accumulated rapidly since. This has led to a better understanding of the clinical utility of MRI in early diagnosis, disease activity assessment, and monitoring of treatment response in axial SpA...
January 2024: International Journal of Rheumatic Diseases
https://read.qxmd.com/read/38283655/impact-of-spondyloarthritis-on-pregnancy-outcome-a-descriptive-analysis-from-a-specialized-center-in-qatar
#16
JOURNAL ARTICLE
Samar Al Emadi, Nawal Nouman Hadwan, Rawan Saleh, Eman Satti, Rajvir Singh
INTRODUCTION: Spondyloarthritis (SpA) most commonly presents at childbearing age; thus, pregnancy is of concern. However, data on pregnancy outcomes in these patients are limited. PURPOSE: This study aimed to retrospectively describe pregnancy outcomes in patients with SpA from the Middle East. PATIENTS AND METHODS: We reviewed the electronic health records of all pregnant women attending a specialized pregnancy and rheumatic disease clinic between 2016 and 2022...
2024: Open Access Rheumatology: Research and Reviews
https://read.qxmd.com/read/38282943/comorbidities-burden-and-implementation-of-the-treat-to-target-strategy-in-predicting-real-world-patient-outcomes-in-spondyloarthritides
#17
JOURNAL ARTICLE
Irini D Flouri, Argyro Repa, Nestor Avgoustidis, Sofia Pitsigavdaki, Katerina Pateromichelaki, Eleni Marolachaki, Maria Terizaki, Myrto Nikoloudaki, Anastasios Eskitzis, Eleni Kalogiannaki, George Bertsias, Prodromos Sidiropoulos
New biologic and small molecule targeted agents have expanded the armamentarium of Spondyloarthritides (SpA), allowing more therapeutic options for patients who do not respond to therapy. The implementation of the treat-to-target (T2T) strategy with close monitoring and frequent treatment adaptations targeting disease remission has been proposed as the means to prevent radiographic progression and long-term adverse outcomes. In this project we will employ the "University of Crete Rheumatology Clinic Registry" to prospectively study in real-world practice musculoskeletal and extraarticular disease activity, patient function, comorbidities, sociodemographics, imaging, compliance to therapy and other lifestyle factors in axial and peripheral SpA patients...
December 2023: Mediterranean journal of rheumatology
https://read.qxmd.com/read/38248792/sex-bias-in-diagnostic-delay-are-axial-spondyloarthritis-and-ankylosing-spondylitis-still-phantom-diseases-in-women-a-systematic-review-and-meta-analysis
#18
REVIEW
Francesca Bandinelli, Bianca Martinelli-Consumi, Mirko Manetti, Maria Sole Vallecoccia
Diagnostic delay (DD) is associated with poor radiological and quality of life outcomes in axial spondyloarthritis (ax-SpA) and ankylosing spondylitis (AS). The female (F) population is often misdiagnosed, as classification criteria were previously studied mostly in males (M). We conducted a systematic review to investigate (i) the difference in DD between the sexes, the impact of HLA*B27 and clinical and social factors (work and education) on this gap, and (ii) the possible influence of the year of publication (before and after the 2009 ASAS classification criteria), geographical region (Europe and Israel vs...
January 13, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38237920/exploring-the-unifying-concept-of-spondyloarthritis-a-latent-class-analysis-of-the-regisponser-registry
#19
JOURNAL ARTICLE
Xabier Michelena, Alexandre Sepriano, Sizheng Steven Zhao, Clementina López-Medina, Eduardo Collantes-Estévez, Pilar Font-Ugalde, Xavier Juanola, Helena Marzo-Ortega
OBJECTIVES: The aim of our study is to identify the potential distinct phenotypes within a broad Spondyloarthritis (SpA) population. METHODS: We conducted a cross-sectional study using the REGISPONSER registry with data from 31 specialist centres in Spain including patients with SpA who fulfilled the European Spondyloarthropathy Study Group (ESSG) criteria. A latent class analysis (LCA) was performed to identify the latent classes underlying SpA according to a set of predefined clinical and radiographic features, independently of expert opinion...
January 17, 2024: Rheumatology
https://read.qxmd.com/read/38233104/can-rheumatologists-unequivocally-diagnose-axial-spondyloarthritis-in-patients-with-chronic-back-pain-of-less-than-2-years-duration-primary-outcome-of-the-2-year-spondyloarthritis-caught-early-space-cohort
#20
JOURNAL ARTICLE
Mary Lucy Marques, Sofia Ramiro, Miranda van Lunteren, Rosalinde Anne Stal, Robert Bm Landewé, Marleen van de Sande, Karen Minde Fagerli, Inger Jorid Berg, Maikel van Oosterhout, Sofia Exarchou, Roberta Ramonda, Désirée van der Heijde, Floris A van Gaalen
OBJECTIVES: To investigate the prevalence of axial spondyloarthritis (axSpA) in patients with chronic back pain (CBP) of less than 2 years (2y) duration referred to the rheumatologist, the development of diagnosis over time, and patient characteristics of those developing definite (d-)axSpA over 2y. METHODS: We analysed the 2y data from SPondyloArthritis Caught Early, a European cohort of patients (<45 years) with CBP (≥3 months, ≤2y) of unknown origin...
February 8, 2024: Annals of the Rheumatic Diseases
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