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https://www.readbyqxmd.com/read/27903446/polycystic-ovary-syndrome-an-under-recognized-cause-of-abnormal-uterine-bleeding-in-adolescents-admitted-to-a-children-s-hospital
#1
Sofya Maslyanskaya, Hina J Talib, Jennifer L Northridge, Amanda M Jacobs, Chanelle Coble, Susan M Coupey
STUDY OBJECTIVE: To evaluate whether ovulatory dysfunction due to polycystic ovary syndrome (PCOS) is a common underlying etiology of abnormal uterine bleeding (AUB) in adolescents requiring hospitalization and to explore etiology, treatment and complications of AUB with severe anemia in adolescents. DESIGN: We identified females aged 8 to 20 years admitted to a children's hospital for treatment of AUB from January 2000 to December 2014. Our hospital protocol advises hormonal testing for PCOS and other disorders prior to treatment for AUB...
November 26, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27899527/biased-agonists-of-the-kappa-opioid-receptor-suppress-pain-and-itch-without-causing-sedation-or-dysphoria
#2
Tarsis F Brust, Jenny Morgenweck, Susy A Kim, Jamie H Rose, Jason L Locke, Cullen L Schmid, Lei Zhou, Edward L Stahl, Michael D Cameron, Sarah M Scarry, Jeffrey Aubé, Sara R Jones, Thomas J Martin, Laura M Bohn
Agonists targeting the kappa opioid receptor (KOR) have been promising therapeutic candidates because of their efficacy for treating intractable itch and relieving pain. Unlike typical opioid narcotics, KOR agonists do not produce euphoria or lead to respiratory suppression or overdose. However, they do produce dysphoria and sedation, side effects that have precluded their clinical development as therapeutics. KOR signaling can be fine-tuned to preferentially activate certain pathways over others, such that agonists can bias signaling so that the receptor signals through G proteins rather than other effectors such as βarrestin2...
November 29, 2016: Science Signaling
https://www.readbyqxmd.com/read/27836285/practical-aspects-of-the-two-figo-systems-for-management-of-abnormal-uterine-bleeding-in-the-reproductive-years
#3
REVIEW
Malcolm G Munro
The FIGO systems defining the nomenclature and symptoms of abnormal uterine bleeding (AUB) in the reproductive years (System 1) and the PALM-COEIN classification of causes of AUB (System 2) are designed to facilitate research, education, and the provision of optimum clinical care for affected women. Development of these systems has been the result of a collaborative effort of experts in bench and translational and clinical research from six continents aided by a spectrum of representatives from relevant medical societies, journals, and regulatory bodies...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27818130/structured-imaging-technique-in-the-gynecologic-office-for-the-diagnosis-of-abnormal-uterine-bleeding
#4
REVIEW
Margit Dueholm, Ina Marie D Hjorth
: The aim in the diagnosis of abnormal uterine bleeding (AUB) is to identify the bleeding cause, which can be classified by the PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system. In a gynecologic setting, the first step is most often to identify structural abnormalities (PALM causes). Common diagnostic options for the identification of the PALM include ultrasonography, endometrial sampling, and hysteroscopy...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27796406/-prognostic-assessment-in-private-healthcare-insurance-part%C3%A2-2-risk-supplement-for-accidental-endoprostheses
#5
H-T Klemm, A Naumann, G Hofmann, G Spahn
After examining the causes of an accident the medical expert working in the area of private health care insurance under the general accident insurance (AUB) sample conditions must ascertain incapacity within a period of time that has been contractually agreed between the parties involved. In addition, this must also state their position on the question as to whether there may exist any circumstances up to the latest possible point in time in insurance terms that would comprise an adequate prognosis of a future change in the long-term condition...
October 28, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27796405/-prognostic-assessment-in-private-healthcare-insurance-part-1-risk-of-osteoarthritis
#6
H-T Klemm, A Naumann, G Hofmann, G Spahn
After examining the cause of an accident the medical expert working in the area of private health care insurance under the general accident insurance (AUB) sample conditions must ascertain incapacity within a period of time that has been contractually agreed upon between the parties involved. In addition, this person must also state their position on the question as to whether there may exist any circumstances up to the latest possible point in time in insurance terms that would comprise an adequate prognosis of a future change in the long-term condition...
October 28, 2016: Der Unfallchirurg
https://www.readbyqxmd.com/read/27787478/dysfunctional-uterine-bleeding-as-an-early-sign-of-polycystic-ovary-syndrome-during-adolescence-an-update
#7
Efthimios Deligeoroglou, Vasileios Karountzos
AIM: Abnormal Uterine Bleeding (AUB) is a frequent reason for concern between adolescents. The most common cause of AUB in these girls, when other pathologies have been excluded, is Dysfunctional Uterine Bleeding (DUB). The aim of this review is to assess the role of DUB as an early symptom of Polycystic Ovarian Syndrome (PCOS) diagnosis later in life. METHODS: Review of the literature, using Pubmed and Medline as primary databases, regarding the correlation between DUB cases early after menarche and PCOS diagnosis in the future...
October 27, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27784616/the-role-of-leiomyomas-in-the-genesis-of-abnormal-uterine-bleeding-aub
#8
REVIEW
Ricardo Bassil Lasmar, Bernardo Portugal Lasmar
Abnormal uterine bleeding (AUB) is the major complaint in approximately one-third of gynecological visits in premenopausal women, and in >70% of appointments of perimenopausal and postmenopausal women. Uterine myoma is one of the main causes of AUB during menacme, especially when it is submucosal. The association of myoma and AUB may be related to several factors, from local alterations of angiogenic and vasoactive substances to changes in uterine contractility. The objective of this paper is to show the different associations of myoma and AUB...
October 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27737575/the-remarkable-change-in-euro-american-cranial-shape-and-size
#9
Richard L Jantz, Lee Meadows Jantz
Secular changes in stature, weight, or other components of the body that can be obtained from historical records have been extensively studied. Cranial change has been central to anthropology for more than a century, but the focus has normally been on change measured in centuries or millennia. Cranial change measured in decades, normally considered to result from plastic response to the environment, has been less studied. This article reports on change in cranial vault dimensions in white Americans. Variables were glabello-occipital length (GOL), basion-bregma height (BBH), basion-nasion length (BNL), maximum cranial breadth (XCB), and biauricular breadth (AUB)...
January 2016: Human Biology
https://www.readbyqxmd.com/read/27721027/the-utility-of-routine-ultrasound-in-the-diagnosis-and-management-of-adolescents-with-abnormal-uterine-bleeding
#10
Yael Pecchioli, Lamide Oyewumi, Lisa M Allen, Sari Kives
STUDY OBJECTIVE: Despite the fact that most cases of abnormal uterine bleeding (AUB) in adolescence are due to an immature hypothalamic-pituitary-ovarian axis (HPO), the current approach to investigating adolescents presenting with AUB often includes pelvic ultrasound to exclude rare structural causes. The aim of this study was to determine whether an ultrasound ordered for the investigation of AUB in adolescents detects any significant anatomic pathology or alters diagnosis and management...
October 6, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27521876/management-of-abnormal-uterine-bleeding-with-emphasis-on-alternatives-to-hysterectomy
#11
REVIEW
Megan R Billow, Sherif A El-Nashar
Abnormal uterine bleeding (AUB) is a common problem that negatively impacts a woman's health-related quality of life and activity. Initial medical treatment includes hormonal and nonhormonal medications. If bleeding persists and no structural abnormalities are present, a repeat trial of medical therapy, a levonorgestrel intrauterine system, or an endometrial ablation can be used dependent on future fertility wishes. The levonorgestrel intrauterine system and endometrial ablation are effective, less invasive, and safe alternatives to a hysterectomy in women with AUB...
September 2016: Obstetrics and Gynecology Clinics of North America
https://www.readbyqxmd.com/read/27504357/clinical-study-of-endometrial-polyp-and-role-of-diagnostic-hysteroscopy-and-blind-avulsion-of-polyp
#12
Janu Mangala Kanthi, Chithra Remadevi, Sudha Sumathy, Deepti Sharma, Sarala Sreedhar, Amrutha Jose
INTRODUCTION: Endometrial polyp is one of the common causes of Abnormal Uterine Bleeding (AUB) in the reproductive age group as well as postmenopausal age group. AIM: To study the clinical features of endometrial polyp and the safety and feasibility of blind polypectomy following diagnostic hysteroscopy. MATERIALS AND METHODS: Total of 256 women who were diagnosed to have endometrial polyp by transvaginal ultrasound and underwent diagnostic hysteroscopy and blind polypectomy by simple avulsion in the period of January 2008 to December 2014 were included in our study...
June 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27499594/abnormal-uterine-bleeding-in-perimenopausal-women-correlation-with-sonographic-findings-and-histopathological-examination-of-hysterectomy-specimens
#13
Bharat Talukdar, Sangita Mahela
BACKGROUND: Abnormal uterine bleeding (AUB) is a frequently encountered gynecologic complaint in perimenopausal woman and also the most common cause of hysterectomy in this age group. OBJECTIVE: Evaluation of various clinical presentations of perimenopausal AUB and it is ultrasonographic and histopathological correlation of hysterectomy specimens. MATERIALS AND METHODS: This study was carried out in the Department of Obstetrics and Gynaecology among perimenopausal women who underwent hysterectomy for AUB...
April 2016: Journal of Mid-life Health
https://www.readbyqxmd.com/read/27320195/rna-helicase-spn-e-is-required-to-maintain-aub-and-ago3-protein-levels-for-pirna-silencing-in-the-germline-of-drosophila
#14
Sergei S Ryazansky, Alexei A Kotov, Mikhail V Kibanov, Natalia V Akulenko, Alina P Korbut, Sergei A Lavrov, Vladimir A Gvozdev, Ludmila V Olenina
Germline-specific RNA helicase Spindle-E (Spn-E) is known to be essential for piRNA silencing in Drosophila that takes place mainly in the perinuclear nuage granules. Loss-of-function spn-E mutations lead to tandem Stellate genes derepression in the testes and retrotransposon mobilization in the ovaries. However, Spn-E functions in the piRNA pathway are still obscure. Analysis of total library of short RNAs from the testes of spn-E heterozygous flies revealed the presence of abundant piRNA ping-pong pairs originating from Su(Ste) transcripts...
September 2016: European Journal of Cell Biology
https://www.readbyqxmd.com/read/27284943/abnormal-uterine-bleeding-unrelated-to-uterine-structural-abnormalities-management-in-the-perimenopausal-period
#15
Lorenzo Sabbioni, Isabella Zanetti, Cinzia Orlandini, Felice Petraglia, Stefano Luisi
Abnormal uterine bleeding (AUB) is one of the commonest health problems encountered by women and a frequent phenomenon during menopausal transition. The clinical management of AUB must follow a standardized classification system to obtain the better diagnostic pathway and the optimal therapy. The PALM-COEIN classification system has been approved by the International Federation of Gynecology and Obstetrics (FIGO); it recognizes structural causes of AUB, which can be measured visually with imaging techniques or histopathology, and non- structural entities such as coagulopathies, ovulatory dysfunctions, endometrial and iatrogenic causes and disorders not yet classified...
June 10, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27121409/-see-and-treat-hysteroscopy-in-the-management-of-endometrial-polyps
#16
Morris Wortman
Endometrial polyps (EPs) are a common cause of abnormal uterine bleeding (AUB) in perimenopausal and postmenopausal women and are typically suggested by a screening transvaginal ultrasound. In addition, the increasing use of pelvic imaging often discloses asymptomatic EPs. In the past, saline infusion sonography (SIS) has been advocated in order to triage patients to undergo a blind curettage or a diagnostic or operative hysteroscopy. The introduction of small diameter hysteroscopes and resectoscopes-often no larger than a SIS catheter-now allows most women with abnormal ultrasound findings to undergo a single-stage "see-and-treat" hysteroscopy for the management of endometrial polyps...
April 2016: Surgical Technology International
https://www.readbyqxmd.com/read/26952349/comparison-of-classic-terminology-with-the-figo-palm-coein-system-for-classification-of-the-underlying-causes-of-abnormal-uterine-bleeding
#17
Emrah Töz, Muzaffer Sancı, Aykut Özcan, Emrah Beyan, Abdurrahman H İnan
OBJECTIVE: To compare classic terminology and the PALM-COEIN (polyp, adenomyosis, leiomyoma, malignancy and hyperplasia, coagulopathy, ovulatory disorders, endometrium, iatrogenic, and not classified) classification system among women who underwent surgery for abnormal uterine bleeding (AUB), and to subclassify the components of the PALM group for future studies. METHODS: In a retrospective study, data were obtained for nonpregnant women aged 18-55years who underwent hysterectomy, myomectomy, or polypectomy for AUB at a center in Turkey in 2014...
June 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/26912000/the-role-of-decidual-cells-in-uterine-hemostasis-menstruation-inflammation-adverse-pregnancy-outcomes-and-abnormal-uterine-bleeding
#18
REVIEW
Frederick Schatz, Ozlem Guzeloglu-Kayisli, Sefa Arlier, Umit A Kayisli, Charles J Lockwood
BACKGROUND: Human pregnancy requires robust hemostasis to prevent hemorrhage during extravillous trophoblast (EVT) invasion of the decidualized endometrium, modification of spiral arteries and post-partum processes. However, decidual hemorrhage (abruption) can occur throughout pregnancy from poorly transformed spiral arteries, causing fetal death or spontaneous preterm birth (PTB), or it can promote the aberrant placentation observed in intrauterine growth restriction (IUGR) and pre-eclampsia; all leading causes of perinatal or maternal morbidity and mortality...
June 2016: Human Reproduction Update
https://www.readbyqxmd.com/read/26803558/abnormal-uterine-bleeding
#19
Lucy Whitaker, Hilary O D Critchley
Abnormal uterine bleeding (AUB) is a common and debilitating condition with high direct and indirect costs. AUB frequently co-exists with fibroids, but the relationship between the two remains incompletely understood and in many women the identification of fibroids may be incidental to a menstrual bleeding complaint. A structured approach for establishing the cause using the Fédération International de Gynécologie et d'Obstétrique (FIGO) PALM-COEIN (Polyp, Adenomyosis, Leiomyoma, Malignancy (and hyperplasia), Coagulopathy, Ovulatory disorders, Endometrial, Iatrogenic and Not otherwise classified) classification system will facilitate accurate diagnosis and inform treatment options...
July 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/26513113/predictive-factors-of-splanchnic-vein-thrombosis-in-acute-pancreatitis-a-6-year-single-center-experience
#20
Laurence Toqué, Antoine Hamy, Jean-Francois Hamel, Elodie Cesbron, Pauline Hulo, Solen Robert, Christophe Aube, Emilie Lermite, Aurélien Venara
OBJECTIVE: Splanchnic vein thrombosis (SVT) is a potentially severe complication of pancreatitis. The aim of this single-center, retrospective cohort study was to investigate the incidence of SVT and to determine the connected risk factors. METHODS: All consecutive patients with acute pancreatitis (AP) managed in our hospital were included. The primary outcome was the occurrence of SVT and data was collected in accordance with Ranson's criteria. RESULTS: A total of 318 patients were included, of whom 124 (39...
December 2015: Journal of Digestive Diseases
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