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Metabonomics

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https://www.readbyqxmd.com/read/29658313/metabonomic-analysis-of-toxic-action-of-long-term-low-level-exposure-to-acrylamide-in-rat-serum
#1
C Cao, H Shi, M Zhang, L Bo, L Hu, S Li, S Chen, S Jia, Y J Liu, Y L Liu, X Zhao, L Zhang
This study assessed the effects of long-term, low-dose acrylamide (AA) administration in rats using ultra-performance liquid chromatography-mass spectrometry. Forty male Wistar rats were randomly divided into the following four groups: control, low-dose AA (0.2 mg/kg BW), middle-dose AA (1 mg/kg BW), and high-dose AA (5 mg/kg BW). AA was administered to rats via drinking water ad libitum. After 16-week treatment, rat serum was collected for metabonomic analysis. Biochemical tests were further conducted to verify metabolic alterations...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29644395/metabolic-phenotyping-of-malnutrition-during-the-first-1000-days-of-life
#2
REVIEW
Jordi Mayneris-Perxachs, Jonathan R Swann
Nutritional restrictions during the first 1000 days of life can impair or delay the physical and cognitive development of the individual and have long-term consequences for their health. Metabolic phenotyping (metabolomics/metabonomics) simultaneously measures a diverse range of low molecular weight metabolites in a sample providing a comprehensive assessment of the individual's biochemical status. There are a growing number of studies applying such approaches to characterize the metabolic derangements induced by various forms of early-life malnutrition...
April 11, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29623517/mini-review-on-photosensitization-by-plants-in-grazing-herbivores
#3
REVIEW
Syeda M Hussain, Valdo Rodrigues Herling, Paulo Henrique Mazza Rodrigues, Ishrat Naz, Hamayun Khan, Muhammad Tahir Khan
Photosensitization is severe dermatitis or oxidative/chemical changes in the epidermal tissues activated by the light-induced excitation of molecules within the tissue. It is a series of reactions mediated through light receptors and is more common when the plant-produced metabolites are heterocyclic/polyphenols in nature. The areas affected are exposed body parts and mostly non-pigmented areas with least ultraviolet protection. Similarly, cellular alteration also occurs in the affected animal's dermal tissues and body parts and grazing animals by the accumulation and activation of photodynamic molecules...
April 6, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29605486/integration-of-1-h-nmr-and-uplc-q-tof-ms-based-plasma-metabonomics-study-to-identify-diffuse-axonal-injury-biomarkers-in-rat
#4
Peng Zhang, Shisheng Zhu, Minzhu Zhao, Yalei Dai, Li Zhang, Shijia Ding, Peng Zhao, Jianbo Li
Diffuse axonal injury (DAI) is much common during traumatic brain injury (TBI) and is associated with high mortality and poor neurological outcome. Although many studies have been examined, there are still no reliable objective diagnostic modalities available for clinicians to make an early diagnosis of DAI. Therefore, we established a rat model of DAI, applying an integrated1 H NMR- and UPLC-Q-TOF/MS-based metabonomics approach to identify differentially changed metabolites in plasma. A total of twenty-two metabolites in the injury group were identified as differentially changed...
March 29, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29599826/gas-chromatography-time-of-flight-mass-spectrometry-based-metabonomics-of-changes-in-the-urinary-metabolic-profile-in-osteoarthritic-rats
#5
Hui Jiang, Jian Liu, Xiu-Juan Qin, Yuan-Yuan Chen, Jia-Rong Gao, Mei Meng, Yuan Wang, Ting Wang
The aim of the present study was to explore changes in the urinary metabolic spectrum in rats with knee osteoarthritis, using gas chromatography-time of flight/mass spectrometry (GC-TOF/MS) to determine the metabonomic disease pathogenesis. Sprague-Dawley rats were randomly divided into the control and model groups (n=8/group), and 20 µl of 4% papain and 0.03 M L-cysteine was injected into the right knee on days 1, 3 and 7 to establish the knee osteoarthritis model. Following 14 days, urine was collected over 12 h and cartilage ultrastructural damage was assessed by hematoxylin-eosin staining...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29573298/anti-ageing-effect-of-red-ginseng-revealed-by-urinary-metabonomics-using-rrlc-q-tof-ms
#6
Jinghui Sun, Chuanxin Jiao, Yue Ma, Jianguang Chen, Wei Wu, Shuying Liu
INTRODUCTION: Red ginseng (RG) is one of the main processed products of the roots and rhizomes of Panax ginseng C.A. Meyer and is used for anti-ageing. But how metabonomic influences of RG on the progress of ageing are less researched. OBJECTIVE: A metabonomic method was developed to study the characters of the ageing process and the effects of total ginsenosides of red ginseng (TGRG) on the progress of ageing. METHODS: Urine samples from four different ages (4, 12, 18 and 24 months old) of rats and interference after TGRG were analysed by rapid resolution liquid chromatography coupled with quadruple-time-of-flight mass spectrometry (RRLC-Q-TOF-MS) and multivariate statistical analysis were performed for the pattern recognition and characteristic metabolites identification...
March 24, 2018: Phytochemical Analysis: PCA
https://www.readbyqxmd.com/read/29567573/-1-h-nmr-based-metabolomics-approach-to-investigate-the-urine-samples-of-collagen-induced-arthritis-rats-and-the-intervention-of-tetrandrine
#7
Xinming Yun, Shu Dong, Qiaoqiao Hu, Yue Dai, Yufeng Xia
Tetrandrine is an effective ingredient isolated from the roots of a frequently used medicinal plant Stephania tetrandra S. Moore. It has been used for the management of arthritis in China, but the precise mechanism remains unclear. In the present study, a metabolomics method based on the1 H NMR was constituted to quantify the alterations of the endogenous metabolites in the urines of collagen-induced arthritis (CIA) rats treated with tetrandrine. Data showed that tetrandrine treatment could alleviate the ankle joint swelling and ameliorate histopathological changes in rats...
March 14, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29567533/high-salt-diet-induces-metabolic-alterations-in-multiple-biological-processes-of-dahl-salt-sensitive-rats
#8
Yanjun Wang, Xiangyang Liu, Chen Zhang, Zhengjun Wang
High salt induced renal disease is a condition resulting from the interactions of genetic and dietary factors causing multiple complications. To understand the metabolic alterations associated with renal disease, we comprehensively analyzed the metabonomic changes induced by high salt intake in Dahl salt-sensitive (SS) rats using GC-MS technology and biochemical analyses. Physiological features, serum chemistry, and histopathological data were obtained as complementary information. Our results showed that high salt (HS) intake for 16 weeks caused significant metabolic alterations in both the renal medulla and cortex involving a variety pathways involved in the metabolism of organic acids, amino acids, fatty acids, and purines...
February 2, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29537306/deciphering-metabonomics-biomarkers-targets-interactions-for-psoriasis-vulgaris-by-network-pharmacology
#9
Jiangyong Gu, Li Li, Dongmei Wang, Wei Zhu, Ling Han, Ruizhi Zhao, Xiaojie Xu, Chuanjian Lu
OBJECTIVES: Psoriasis vulgaris is a chronic inflammatory and immune-mediated skin disease. 44 metabonomics biomarkers were identified by high-throughput liquid chromatography coupled to mass spectrometry in our previous work, but the roles of metabonomics biomarkers in the pathogenesis of psoriasis is unclear. METHODS: The metabonomics biomarker-enzyme network was constructed. The key metabonomics biomarkers and enzymes were screened out by network analysis. The binding affinity between each metabonomics biomarker and target was calculated by molecular docking...
March 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29527969/doxorubicin-and-paclitaxel-carried-by-methoxy-poly-ethylene-glycol-poly-lactide-co-glycolide-is-superior-than-traditional-drug-delivery-methods
#10
Yili Hu, Xiaoyang Zhu, Ruifang Zhao, Jin Wang, Yipeng Song, Guangjun Nie, Huiru Tang, Yulan Wang
AIM: To evaluate the advantages of nanomaterial methoxy poly(ethylene glycol)-poly(lactide-co-glycolide) (mPEG-PLGA) encapsulated doxorubicin (D/DOX) and paclitaxel (T/TAX; mPEG-PLGA-DT) over free form of DOX and TAX (DOX/TAX). MATERIALS & METHODS: Metabonomics was conducted to characterize the systemic metabolic response of allograft breast cancer model mice to mPEG-PLGA-DT and DOX/TAX treatments. RESULTS: Breast tumor growth induced metabolic reprogram in serum and multiple organs...
March 12, 2018: Nanomedicine
https://www.readbyqxmd.com/read/29526117/metabonomic-analysis-of-the-therapeutic-effect-of-exendin-4-for-the-treatment-of-tbhp-induced-injury-in-mouse-glomerulus-mesangial-cells
#11
Linxi Wang, Zhiqing Liu, Zhou Chen, Caihua Huang, Xiaohong Liu, Can Chen, Xiaoyin Liu, Jingze Huang, Libin Liu, Donghai Lin
Although previous studies have reported the protective effect of glucagon-like peptide-1 (GLP-1) in diabetes nephropathy, the molecular mechanism such as nephroprotection remains elusive. In this study, we explored the molecular mechanism of exendin-4 as an GLP-1 receptor agonist for the treatment of tert-butyl hydroperoxide (t-BHP)-induced injury in mouse glomerulus mesangial cells (SV40 MES 13 cells) via an NMR-based metabonomic analysis. We found that exendin-4 protected mesangial cells from t-BHP-mediated toxicity, decreased the percentage of t-BHP-treated cells undergoing apoptosis, and restored glucose consumption in the t-BHP-treated group...
March 12, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29522880/systematically-integrated-metabonomic-proteomic-studies-of-escherichia-coli-under-ciprofloxacin-stress
#12
Wanxin Li, Song Zhang, Xiaoyun Wang, Jing Yu, Zeqi Li, Wenxiong Lin, Xiangmin Lin
Many antibiotics are used to kill pathogenic Escherichia coli each year, resulting in an increase in the number of antibiotic-resistant strains. In this study, an integrated metabonomic-proteomic method was performed to systematically compare the profiles of metabolites and proteins with or without ciprofloxacin (CFLX) treatment. Proteomics identified 290 altered proteins including 143 with decreased and 147 increased expression, respectively. Metabonomics identified 65 altered metabolites including 58 and 7 with decreased and increased expression, respectively...
March 6, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29522877/metabonomic-profiling-of-chronic-intermittent-hypoxia-in-a-mouse-model
#13
Stéphanie Conotte, Alexandra Tassin, Raphaël Conotte, Jean-Marie Colet, Karim Zouaoui Boudjeltia, Alexandre Legrand
Chronic intermittent hypoxia (ChIH) is a dominant feature of obstructive sleep apnoea (OSA) and is associated to metabolic alterations and oxidative stress (OS). Although management of OSA is well established, the research of new biomarkers that are independent of confounding factors remains necessary to improve the early detection of comorbidity and therapeutic follow-up. In this study, the urinary metabonomic profile associated to intermittent hypoxia was evaluated in a mouse model. When exposed to intermittent hypoxia, animals showed a significant alteration in energy metabolism towards anaerobic pathways and signs of OS imbalance...
March 6, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29504368/the-implication-of-diabetes-metabolomics-in-the-early-diagnosis-and-pathogenesis-of-pancreatic-cancer
#14
Y B Lou, F X Fan, Y C Mu, X Dong
The aim of this study was to analyze metabolite differences in pancreatic cancer and diabetic patients, to better diagnose these diseases. Gas chromatography-mass spectrometry was used to evaluate the metabolomic differences in blood samples of 50 pancreatic patients, 50 diabetic patients and 50 healthy people. Metabonomic data was analyzed with primary component analysis and discriminant analysis. The results show that pancreatic cancer patients, diabetic patients and healthy people can have significantly distinct metabolite profiles...
January 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29496908/quantitative-phosphoproteomic-and-metabonomic-analyses-reveal-gmmyb173-optimizes-flavonoid-metabolism-in-soybean-under-salt-stress
#15
Erxu Pi, Chengmin Zhu, Wei Fan, Yingying Huang, Liqun Qu, Yangyang Li, Qinyi Zhao, Feng Ding, Lijuan Qiu, Huizhong Wang, B W Poovaiah, Liqun Du
Salinity causes osmotic stress to crops and limits their productivity. To understand the mechanism underlying soybean salt tolerance, proteomics approach was used to identify phosphoproteins altered by NaCl treatment. Results revealed that 412 of the 4698 quantitatively analyzed phosphopeptides were significantly up-regulated upon salt treatment, including a phosphopeptide covering the serine 59 in the transcription factor GmMYB173. Our data showed that GmMYB173 is one of the three MYB proteins differentially phosphorylated upon salt treatment, and a substrate of the casein kinase-II...
March 1, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29483823/the-metabonomics-study-of-p-selectin-glycoprotein-ligand-1-psgl-1-deficiency-inhibiting-the-progression-of-atherosclerosis-in-ldlr-mice
#16
Binglin Li, Xin Lu, Jia Wang, Xiaodong He, Quliang Gu, Lijing Wang, Yongxia Yang
Atherosclerosis (AS) is a multi-factorial chronic disease commonly associated with the mechanisms of metabolism disorder, endothelial dysfunction and chronic inflammation. AS an inflammatory molecule, p-selectin glycoprotein ligand-1 (PSGL-1) played an important role in the inflammatory process of atherogenesis involving the recruitment of leukocyte and transmitting signals to activate leukocyte during the adhesion process. So far, there has been little study regarding the effects of PSGL-1 on AS progression and the metabolic regulation...
2018: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29481741/celecoxib-induced-self-assembly-of-smart-albumin-doxorubicin-conjugate-for-enhanced-cancer-therapy
#17
Leilei Shi, Li Xu, Chenwei Wu, Bai Xue, Xin Jin, Jiapei Yang, Xinyuan Zhu
Recent years have witnessed the great contributions that drug combination therapy has made for enhanced cancer therapy. However, due to the complicated pharmacokinetics of combined drug formulations, the majority of combination strategies show severe adverse effects at high dosage and poor bio-distribution in vivo. To overcome these deficiencies and achieve enhanced cancer therapy, we put forward a method to construct a smart albumin-based nano-platform, denoted as K237-HSA-DC, for co-delivery of Cyclooxygenase-2 (COX-2) inhibitor (celecoxib) and chemotherapeutic agent (doxorubicin, DOX)...
February 26, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29477465/-1-h-nmr-metabolic-signature-of-cerebrospinal-fluid-following-repetitive-lower-limb-remote-ischemia-preconditioning
#18
Hailiang Wang, Zhiyong He, Yijue Zhang, Jun Zhang
Background OBJECTIVE: The cerebral ischemia/reperfusion greatly influences brain metabolism. Remote ischemia preconditioning (RIPC) is reported to confer neuroprotective effects against cerebral ischemia in animal models and human. This study aims to investigate the metabolomic profiles of cerebrospinal fluid (CSF) in patients treated with repetitive lower limb RIPC and provides an insight into possible mechanism underlying RIPC-induced neuroprotection. METHOD: Fifty healthy patients undergoing minor surgery under spinal anesthesia were randomly allocated to 2 groups: control group (Group C, n = 25) and RIPC treatment group (Group T,n = 25)...
February 22, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29474901/arachidonic-acid-metabonomics-study-for-understanding-therapeutic-mechanism-of-huo-luo-xiao-ling-dan-on-rat-model-of-rheumatoid-arthritis
#19
Nannan Wang, Xiaoning Zhao, Jiaxin Huai, Yiran Li, Congcong Cheng, Kaishun Bi, Ronghua Dai
ETHNOPHARMACOLOGICAL RELEVANCE: Huo Luo Xiao Ling Dan (HLXLD), a traditional Chinese medicine (TCM), is commonly used for the treatment of rheumatoid arthritis (RA). AIM OF THE STUDY: To explore the potential therapeutic mechanism of HLXLD on anti-inflammatory activity. MATERIALS AND METHODS: A metabolomic approach based on UFLC-MS/MS to profile arachidonic acid (AA) metabolic changes was used. The cyclooxygenase (COX) and lipoxygenase (LOX) catalyzed metabolites in plasma were quantified on 7, 14, 21, and 28 days after the rats injected with Complete Freund's adjuvant and orally administrated with HLXLD, methotrexate and dexamethasone in parallel as the positive control drugs...
February 20, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29460310/lc-ms-based-metabolic-and-metabonomic-studies-of-panax-ginseng
#20
Wei Wu, Chuanxi Jiao, Hui Li, Yue Ma, Lili Jiao, Shuying Liu
INTRODUCTION: Panax ginseng has received much attention as a valuable health supplement with medicinal potential. Its chemical diversity and multiple pharmacological properties call for comprehensive methods to better understand the effects of ginseng and ginsenosides. Liquid chromatography-mass spectrometry (LC-MS) based metabonomic approaches just fit the purpose. OBJECTIVE: Aims to give a review of recent progress on LC-MS based pharmacokinetic, metabolic, and phytochemical metabolomic studies of ginseng, and metabonomic studies of ginseng intervention effects...
February 19, 2018: Phytochemical Analysis: PCA
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