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https://www.readbyqxmd.com/read/29040959/marantodes-pumilum-kacip-fatimah-enhances-in-vitro-glucose-uptake-in-3t3-l1-adipocyte-cells-and-reduces-pancreatic-complications-in-streptozotocin-nicotinamide-induced-male-diabetic-rats
#1
Siti Hajar Adam, Nelli Giribabu, Noor Mazuin Abu Bakar, Naguib Salleh
Marontades pumilum is claimed to have beneficial effects in the treatment of diabetes mellitus (DM), however the underlying mechanisms were not fully identified. In this study, we hypothesized that M. pumilum could help to enhance cellular glucose uptake and reduces pancreatic complications, which contributed towards its beneficial effects in DM. METHODS: Two parameters were measured (i) rate of glucose uptake by 3T3-L1 adipocyte cells in-vitro (ii) degree of pancreatic destruction in streptozotocin-nicotinamide induced male diabetic rats receiving M...
October 14, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29040572/biallelic-mutations-in-the-ferredoxin-reductase-gene-cause-novel-mitochondriopathy-with-optic-atrophy
#2
Yanyan Peng, Deepali N Shinde, Alex C Valencia, Jun-Song Mo, Jill Rosenfeld, Megan Truitt Cho, Adam Chamberlin, Zhuo Li, Jie Liu, Baoheng Gui, Rachel Brockhage, Alice Basinger, Brenda Alvarez-Leon, Peter Heydemann, Pilar L Magoulas, Andrea M Lewis, Fernando Scaglia, Solange Gril, Shuk Ching Chong, Matthew Bower, Kristin G Monaghan, Rebecca Willaert, Maria-Renee Plona, Rich Dineen, Francisca Milan, George Hoganson, Zoe Powis, Katherine L Helbig, Jennifer Keller-Ramey, Belinda Harris, Laura C Anderson, Torrian Green, Stacey J Sukoff Rizzo, Julie Kaylor, Jiani Chen, Min-Xin Guan, Elizabeth Sellars, Steven P Sparagana, James B Gibson, Laura G Reinholdt, Sha Tang, Taosheng Huang
Iron-sulfur (Fe-S) clusters are ubiquitous cofactors essential to various cellular processes, including mitochondrial respiration, DNA repair, and iron homeostasis. A steadily increasing number of disorders are being associated with disrupted biogenesis of Fe-S clusters. Here, we conducted whole-exome sequencing of patients with optic atrophy and other neurological signs of mitochondriopathy and identified 17 individuals from 13 unrelated families with recessive mutations in FDXR, encoding the mitochondrial membrane-associated flavoprotein ferrodoxin reductase required for electron transport from NADPH to cytochrome P450...
October 5, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29040203/the-temporal-response-and-mechanism-of-action-of-tranexamic-acid-in-endothelial-glycocalyx-degradation
#3
Mark E Diebel, Jonathan V Martin, David M Liberati, Lawrence N Diebel
BACKGROUND: The endothelial glycocalyx (GCX) plays an important role in vascular barrier function. Damage to the GCX occurs due to a variety of causes including hypoxia, ischemia-reperfusion, stress related sympathoadrenal activation, and inflammation. Tranexamic acid (TXA) may prevent GCX degradation. The therapeutic window for TXA administration and the mechanism of action has been under review. Membrane-anchored proteases (sheddases) are key components in endothelial cell biology including the regulation of vascular permeability...
October 16, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29040128/single-dose-preoperative-vitamin-d-supplementation-decreases-infection-in-a-mouse-model-of-periprosthetic-joint-infection
#4
Vishal Hegde, Erik M Dworsky, Alexandra I Stavrakis, Amanda H Loftin, Stephen D Zoller, Howard Y Park, Sherif Richman, Daniel Johansen, Yan Hu, Julie A Taylor, Christopher D Hamad, Rene F Chun, Weixian Xi, John S Adams, Nicholas M Bernthal
BACKGROUND: Despite recent advances, infection remains the most common etiology of arthroplasty failure. Recent work suggests that 25-hydroxyvitamin D (25D) deficiency correlates with the frequency of periprosthetic joint infection (PJI). We endeavored to examine whether 25D3 deficiency leads to increased bacterial burden in vivo in an established mouse model of PJI and, if so, whether this effect can be reversed by preoperative 25D3 supplementation. METHODS: Mice (lys-EGFP) possessing fluorescent neutrophils were fed a vitamin D3-sufficient (n = 20) or deficient (n = 40) diet for 6 weeks...
October 18, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29040105/when-managing-patients-with-left-ventricular-assist-devices-undergoing-noncardiac-surgery-less-is-not-more
#5
Robert E Freundlich, Adam J Kingeter
No abstract text is available yet for this article.
November 2017: Anesthesiology
https://www.readbyqxmd.com/read/29040071/prevalence-and-direct-costs-of-emergency-department-visits-and-hospitalizations-for-selected-diseases-that-can-be-transmitted-by-water-united-states
#6
E A Adam, S A Collier, K E Fullerton, J W Gargano, M J Beach
National emergency department (ED) visit prevalence and costs for selected diseases that can be transmitted by water were estimated using large healthcare databases (acute otitis externa, campylobacteriosis, cryptosporidiosis, Escherichia coli infection, free-living ameba infection, giardiasis, hepatitis A virus (HAV) infection, Legionnaires' disease, nontuberculous mycobacterial (NTM) infection, Pseudomonas-related pneumonia or septicemia, salmonellosis, shigellosis, and vibriosis or cholera). An estimated 477,000 annual ED visits (95% CI: 459,000-494,000) were documented, with 21% (n = 101,000, 95% CI: 97,000-105,000) resulting in immediate hospital admission...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29040053/periostin-as-a-biomarker-for-nasal-polyps-in-chronic-rhinosinusitis
#7
Alice Z Maxfield, Lukas D Landegger, Christopher D Brook, Ashton E Lehmann, Adam P Campbell, Regan W Bergmark, Konstantina M Stankovic, Ralph Metson
Objective Periostin is an extracellular matrix protein that is elevated in the sinonasal tissues of patients with chronic rhinosinusitis (CRS). The purpose of this study was to determine whether serum periostin could serve as a molecular biomarker of nasal polyp burden in sinonasal disease. Study Design Prospective cohort study. Setting Academic medical center. Subjects and Methods Serum periostin levels were measured by ELISA on blood samples collected from patients undergoing sinus surgery for CRS (n = 71), further stratified by phenotype as defined by nasal polyps and asthma...
October 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29040038/ferumoxytol-enhanced-mr-angiography-for-vascular-access-mapping-before-transcatheter-aortic-valve-replacement-in-patients-with-renal-impairment-a-step-toward-patient-specific-care
#8
Kim-Lien Nguyen, John M Moriarty, Adam N Plotnik, Olcay Aksoy, Takegawa Yoshida, Richard J Shemin, William M Suh, J Paul Finn
Purpose To assess the technical feasibility of the use of ferumoxytol-enhanced (FE) magnetic resonance (MR) angiography for vascular mapping before transcatheter aortic valve replacement in patients with renal impairment. Materials and Methods This was an institutional review board-approved and HIPAA-compliant study. FE MR angiography was performed at 3.0 T or 1.5 T. Unenhanced computed tomographic (CT) images were used to overlay vascular calcification on FE MR angiographic images as composite fused three-dimensional data...
October 16, 2017: Radiology
https://www.readbyqxmd.com/read/29039929/mechanistic-basis-for-atp-dependent-inhibition-of-glutamine-synthetase-by-tabtoxinine-%C3%AE-lactam
#9
Garrett Patrick, Luting Fang, Jacob Schaefer, Sukrit Singh, Gregory Bowman, Timothy Adam Wencewicz
Tabtoxinine-β-lactam (TβL), also known as wildfire toxin, is a time- and ATP-dependent inhibitor of glutamine synthetase produced by plant pathogenic strains of Pseudomonas syringae. Here we demonstrate that recombinant glutamine synthetase from E. coli phosphorylates the C3-hydroxyl group of the TβL 3-(R)-hydroxy-β-lactam (3-HβL) warhead. Phosphorylation of TβL generates a stable, non-covalent enzyme-ADP-inhibitor complex that resembles the glutamine synthetase tetrahedral transition state. The TβL β-lactam ring remains intact during enzyme inhibition making TβL mechanistically distinct from traditional β-lactam antibiotics such as penicillin...
October 17, 2017: Biochemistry
https://www.readbyqxmd.com/read/29036945/what-s-your-micromort-a-patient-oriented-analysis-of-breast-implant-associated-anaplastic-large-cell-lymphoma-bia-alcl
#10
David A Sieber, William P Adams
Breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) continues to be a rare and elusive malignancy. Because BIA-ALCL does not behave like traditional lymphomas, additional research needs to be conducted to further delineate the lymphoproliferative nature of BIA-ALCL. An estimated 35 million women worldwide have breast implants and the total reported deaths from BIA-ALCL is 12 to date. The term micromort was introduced in 1979 by Ronald Howard as a person's risk of dying as 1 in a million. Drinking 0...
September 1, 2017: Aesthetic Surgery Journal
https://www.readbyqxmd.com/read/29036773/a-young-woman-with-yellow-hands-and-secondary-amenorrhoea
#11
Adam Morton, Sarah Morton
No abstract text is available yet for this article.
October 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29036643/glass-assisted-and-standardized-assessment-of-gene-variations-from-sanger-sequence-trace-data
#12
Karol Pal, Vojtech Bystry, Tomas Reigl, Martin Demko, Adam Krejci, Tasoula Touloumenidou, Evangelia Stalika, Boris Tichy, Paolo Ghia, Kostas Stamatopoulos, Sarka Pospisilova, Jitka Malcikova, Nikos Darzentas
Motivation: Sanger sequencing is still being employed for sequence variant detection by many laboratories, especially in a clinical setting. However, chromatogram interpretation often requires manual inspection and in some cases, considerable expertise. Results: We present GLASS, a web-based Sanger sequence trace viewer, editor, aligner and variant caller, built to assist with the assessment of variations in 'curated' or user-provided genes. Critically, it produces a standardized variant output as recommended by the Human Genome Variation Society...
July 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036439/do-brief-alcohol-interventions-among-unemployed-at-risk-drinkers-increase-re-employment-after-15-month
#13
Katja Haberecht, Sophie Baumann, Gallus Bischof, Beate Gaertner, Ulrich John, Jennis Freyer-Adam
Background: At-risk alcohol use is associated bi-directionally to unemployment, and decreases chances of re-employment. Brief alcohol interventions (BAI) can reduce at-risk alcohol use. This study aimed to investigate 15-month effects of BAI on unemployment among persons with at-risk alcohol use. Methods: As part of the randomized controlled 'Trial on proactive alcohol interventions among job-seekers, TOPAS', 1243 18- to 64-year-old job-seekers with at-risk alcohol use were systematically recruited at three job agencies in Germany (2008/09), and randomized to (i) a stage tailored intervention based on the trans-theoretical model of intentional behavior change (ST), (ii) a non-stage tailored intervention based on the theory of planned behavior (NST) and (iii) assessment only (AO)...
October 5, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/29036258/serpiginous-purpuric-eruption-of-the-leg
#14
Kristin Totoraitis, Cynthia M Magro, Adam Friedman
A previously healthy 68-year-old male presented with a rash on his right lower leg. The lesions had spread along the leg since onset 9 days prior, and the patient reported localized soreness and pruritus. He denied systemic symptoms including fever, fatigue, myalgia, joint pain, and recent illness. Physical examination revealed a serpiginous, purpuric eruption on the anterior and posterior right thigh and lower leg. A 4mm punch biopsy from the right lower leg revealed a Th2 dominant process reflective of a type IV delayed hypersensitivity reaction...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29036225/human-plasma-derived-c1-esterase-inhibitor-concentrate-has-limited-effect-on-house-dust-mite-induced-allergic-lung-inflammation-in-mice
#15
Ingrid Stroo, Jack Yang, Adam A Anas, J Daan de Boer, Gerard van Mierlo, Dorina Roem, Diana Wouters, Ruchira Engel, Joris J T H Roelofs, Cornelis van 't Veer, Tom van der Poll, Sacha Zeerleder
C1 esterase inhibitor (C1-INH) can inhibit multiple pathways (complement, contact-kinin, coagulation, and fibrinolysis) that are all implicated in the pathophysiology of asthma. We explored the effect of human plasma-derived C1-INH on allergic lung inflammation in a house dust mite (HDM) induced asthma mouse model by daily administration of C1-INH (15 U) during the challenge phase. NaCl and HDM exposed mice had comparable plasma C1-INH levels, while bronchoalveolar lavage fluid (BALF) levels were increased in HDM exposed mice coinciding with slightly reduced activation of complement (C5a)...
2017: PloS One
https://www.readbyqxmd.com/read/29036198/the-homeodomain-interacting-protein-kinase-hpk-1-preserves-protein-homeostasis-and-longevity-through-master-regulatory-control-of-the-hsf-1-chaperone-network-and-torc1-restricted-autophagy-in-caenorhabditis-elegans
#16
Ritika Das, Justine A Melo, Manjunatha Thondamal, Elizabeth A Morton, Adam B Cornwell, Beresford Crick, Joung Heon Kim, Elliot W Swartz, Todd Lamitina, Peter M Douglas, Andrew V Samuelson
An extensive proteostatic network comprised of molecular chaperones and protein clearance mechanisms functions collectively to preserve the integrity and resiliency of the proteome. The efficacy of this network deteriorates during aging, coinciding with many clinical manifestations, including protein aggregation diseases of the nervous system. A decline in proteostasis can be delayed through the activation of cytoprotective transcriptional responses, which are sensitive to environmental stress and internal metabolic and physiological cues...
October 16, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29036187/analysis-of-transient-hypermorphic-activity-of-e-spl-d-during-r8-specification
#17
Adam T Majot, Ashok P Bidwai
Drosophila atonal (ato) is required for the specification of founding R8 photoreceptors during retinal development. ato is regulated via dual eye-specific enhancers; ato-3' is subject to initial induction whereas 5'-ato facilitates Notch-mediated autoregulation. Notch is further utilized to induce bHLH repressors of the E(spl) locus to restrict Ato from its initial broad expression to individual cells. Although Notch operates in two, distinct phases, it has remained unclear how the two phases maintain independence from one another...
2017: PloS One
https://www.readbyqxmd.com/read/29036109/transparency-in-stereopsis-parallel-encoding-of-overlapping-depth-planes
#18
Adam Reeves, David Lynch
We report that after extensive training, expert adults can accurately report the number, up to six, of transparent overlapping depth planes portrayed by brief (400 ms or 200 ms) random-element stereoscopic displays, and can well discriminate six from seven planes. Naïve subjects did poorly above three planes. Displays contained seven rows of 12 randomly located ×'s or +'s; jittering the disparities and number in each row to remove spurious cues had little effect on accuracy. Removing the central 3° of the 10° display to eliminate foveal vision hardly reduced the number of reportable planes...
August 1, 2017: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29035942/phase-ii-randomized-sham-controlled-study-of-renal-denervation-for-individuals-with-uncontrolled-hypertension-wave-iv
#19
Roland E Schmieder, Christian Ott, Stefan W Toennes, Peter Bramlage, Michael Gertner, Omar Dawood, Peter Baumgart, Benjamin O'Brien, Indranil Dasgupta, Georg Nickenig, John Ormiston, Manish Saxena, Andrew S P Sharp, Horst Sievert, Jindrich Spinar, Zdenek Starek, Joachim Weil, Ulrich Wenzel, Adam Witkowski, Melvin D Lobo
OBJECTIVES: The aim of this double-blind, randomized, sham-controlled study was to verify the blood pressure (BP)-lowering efficacy of externally delivered focused ultrasound for renal denervation (RDN). BACKGROUND: Nonrandomized, first proof-of-concept study and experimental evidence suggested that noninvasive techniques of RDN emerged as an alternative approach of RDN to invasive technologies. METHODS: WAVE IV, an international, randomized (1 : 1) sham-controlled, double-blind prospective clinical study, was prematurely stopped...
October 13, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29035896/intraoperative-phototherapy-for-hyperbilirubinemia
#20
Adam C Adler
No abstract text is available yet for this article.
October 16, 2017: Anesthesiology
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