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https://www.readbyqxmd.com/read/28431410/gravity-stress-radiographs-and-the-effect-of-ankle-position-on-deltoid-ligament-integrity-and-medial-clear-space-measurements
#1
Ali Ashraf, Jacob Murphree, Eric Wait, Travis Winston, Adam Wooldridge, Matthew Meriwether, Joshua Wilson, Jerry S Grimes
INTRODUCTION: External rotation and gravity stress radiographs have been described to distinguish stable supination-external rotation-II (SER-II) ankle fractures from unstable SER-IV fractures. It has been previously shown that both external rotation and gravity stress views are equivalent in their ability to diagnose deltoid ligament injury. It has also been shown that the position of the ankle influences the external rotation stress radiograph. However, no data of ankle position exist for gravity stress radiographs...
May 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28431408/the-effects-of-exercise-modality-during-additional-high-intensity-interval-training-upon-aerobic-fitness-and-strength-in-powerlifting-and-strongman-athletes
#2
Patroklos Androulakis-Korakakis, Louis Langdown, Adam Lewis, James Fisher, Paulo Gentil, Antonio Paoli, James Steele
Powerlifters and strongman athletes have a necessity for optimal levels of muscular strength whilst maintaining sufficient aerobic capacity to perform and recover between events. HIIT has been popularized for its efficacy in improving both aerobic fitness and strength but never assessed within the aforementioned population group. The present study looked to compare the effect of exercise modality, e.g. a traditional aerobic mode (AM), and strength mode, (SM), during HIIT upon aerobic fitness and strength. Sixteen well resistance trained male participants, currently competing in powerlifting and strongman events, completed 8 weeks of approximately effort- and volume-matched HIIT in 2 groups: AM (cycling, n=8) and SM (resistance training, n=8)...
April 21, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28431260/standardization-of-brief-inventory-of-social-support-exchange-network-bissen-in-japan
#3
Miyuki Aiba, Hirokazu Tachikawa, Yoshiharu Fukuoka, Adam Lebowitz, Yuki Shiratori, Nagafumi Doi, Yutaka Matsui
This study describes the Brief Inventory of Social Support Exchange Network (BISSEN) as a standardized brief inventory measuring various aspects of social support. We confirmed the reliability and validity for function and direction of support and standardized the BISSEN. For Sample 1, a stratified random sampling method was used to select 5200 residents in Japan. We conducted mail surveys and responses were retrieved from 2274 participants (collection rate 43.7%). Participants completed a questionnaire packet that included BISSEN, suicidal ideation, depression, support seeking, and Multidimensional Scale of Perceived Social Support (MSPSS)...
April 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28431242/structural-and-functional-analysis-of-a-%C3%AE-2-adrenergic-receptor-complex-with-grk5
#4
Konstantin E Komolov, Yang Du, Nguyen Minh Duc, Robin M Betz, João P G L M Rodrigues, Ryan D Leib, Dhabaleswar Patra, Georgios Skiniotis, Christopher M Adams, Ron O Dror, Ka Young Chung, Brian K Kobilka, Jeffrey L Benovic
The phosphorylation of agonist-occupied G-protein-coupled receptors (GPCRs) by GPCR kinases (GRKs) functions to turn off G-protein signaling and turn on arrestin-mediated signaling. While a structural understanding of GPCR/G-protein and GPCR/arrestin complexes has emerged in recent years, the molecular architecture of a GPCR/GRK complex remains poorly defined. We used a comprehensive integrated approach of cross-linking, hydrogen-deuterium exchange mass spectrometry (MS), electron microscopy, mutagenesis, molecular dynamics simulations, and computational docking to analyze GRK5 interaction with the β2-adrenergic receptor (β2AR)...
April 20, 2017: Cell
https://www.readbyqxmd.com/read/28431150/the-natural-history-of-children-with-joint-hypermobility-syndrome-and-ehlers-danlos-hypermobility-type-a-longitudinal-cohort-study
#5
Mark C Scheper, Lesley L Nicholson, Roger D Adams, Louise Tofts, Verity Pacey
Objectives.: The objective of the manuscript was to describe the natural history of complaints and disability in children diagnosed with joint hypermobility syndrome (JHS)/Ehlers-Danlos-hypermobility type (EDS-HT) and to identify the constructs that underlie functional decline. Methods.: One hundred and one JHS/EDS-HT children were observed over 3 years and assessed at three time points on the following: functional impairments, quality of life, connective tissue laxity, muscle function, postural control and musculoskeletal and multi-systemic complaints...
April 18, 2017: Rheumatology
https://www.readbyqxmd.com/read/28430862/how-health-related-quality-of-life-assessment-should-be-used-in-advanced-colorectal-cancer-clinical-trials
#6
F Bonnetain, C Borg, R R Adams, J A Ajani, A Benson, H Bleiberg, B Chibaudel, E Diaz-Rubio, J Y Douillard, C S Fuchs, B J Giantonio, R Goldberg, V Heinemann, M Koopman, R Labianca, A K Larsen, T Maughan, E Mitchell, M Peeters, C J A Punt, H J Schmoll, C Tournigand, A de Gramont
Traditionally, the efficacy of cancer treatment in patients with advance or metastatic disease in clinical studies has been studied using overall survival (OS) and more recently tumor-based endpoints such as progression-free survival, measurements of response to treatment. However, these seem not to be the relevant clinical endpoints in current situation if such endpoints were no validated as surrogate of OS to demonstrate the clinical efficacy. Appropriate, meaningful, primary patient-oriented and patient-reported endpoints that adequately measure the effects of new therapeutic interventions are then crucial for the advancement of clinical research in metastatic colorectal cancer to complement the results of tumor-based endpoints...
April 18, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28430775/early-career-investigator-highlight
#7
Adam Frymoyer
Pediatric Research accepted article preview online, 21 April 2017. doi:10.1038/pr.2017.60.
April 21, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28430722/the-use-of-liposomal-bupivacaine-administered-with-standard-bupivacaine-in-ankle-fractures-requiring-open-reduction-internal-fixation-a-single-blinded-randomized-controlled-trial
#8
Roy Davidovitch, Abraham Goch, Adam Driesman, Sanjit Konda, Christian Pean, Kenneth Egol
OBJECTIVES: To determine the efficacy of liposomal bupivacaine compared to placebo for post-operative pain control in patients undergoing operative fixation of ankle fractures. DESIGN: Prospective single blinded randomized control trial SETTING:: Academic Medical CenterPatients/Participants: After IRB approval, seventy-six patients who sustained an acute ankle fracture (OTA 44A-C) requiring operative fixation met inclusion criteria. INTERVENTION: Patients were randomly assigned to one of two groups, control (local intra-operative sterile saline injection under general anesthesia) or interventional (local intra-operative liposomal bupivacaine and bupivacaine injection under general anesthesia)...
April 6, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28430720/the-effect-of-insertion-technique-on-temperatures-for-standard-and-self-drilling-external-fixation-pins
#9
Sarah Manoogian, Adam K Lee, James C Widmaier
OBJECTIVES: No studies have assessed the effects of parameters associated with insertion temperature in modern self-drilling external fixation pins. The current study assessed how varying the presence of irrigation, insertion speed, and force impacted the insertion temperatures of two types of standard and self-drilling external fixation half pins. METHODS: Seventy tests were conducted with ten trials for four conditions on self-drilling pins and three conditions for standard pins...
April 6, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28430697/abusive-head-trauma-and-mortality-an-analysis-from-an-international-comparative-effectiveness-study-of-children-with-severe-traumatic-brain-injury
#10
Nikki Miller Ferguson, Ajit Sarnaik, Darryl Miles, Nadeem Shafi, Mark J Peters, Edward Truemper, Monica S Vavilala, Michael J Bell, Stephen R Wisniewski, James F Luther, Adam L Hartman, Patrick M Kochanek
OBJECTIVES: Small series have suggested that outcomes after abusive head trauma are less favorable than after other injury mechanisms. We sought to determine the impact of abusive head trauma on mortality and identify factors that differentiate children with abusive head trauma from those with traumatic brain injury from other mechanisms. DESIGN: First 200 subjects from the Approaches and Decisions in Acute Pediatric Traumatic Brain Injury Trial-a comparative effectiveness study using an observational, cohort study design...
April 20, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28430550/round-table-on-malignant-hyperthermia-in-physically-active-populations-meeting-proceedings
#11
Yuri Hosokawa, Douglas J Casa, Henry Rosenberg, John F Capacchione, Emmanuel Sagui, Sheila Riazi, Luke N Belval, Patricia A Deuster, John F Jardine, Stavros A Kavouras, Elaine C Lee, Kevin C Miller, Sheila M Muldoon, Francis G O'Connor, Scott R Sailor, Nyamkhishig Sambuughin, Rebecca L Stearns, William M Adams, Robert A Huggins, Lesley W Vandermark
CONTEXT:   Recent case reports on malignant hyperthermia (MH)-like syndrome in physically active populations indicate potential associations among MH, exertional heat stroke (EHS), and exertional rhabdomyolysis (ER). However, an expert consensus for clinicians working with these populations is lacking. OBJECTIVE:   To provide current expert consensus on the (1) definition of MH; (2) history, etiology, and pathophysiology of MH; (3) epidemiology of MH; (4) association of MH with EHS and ER; (5) identification of an MH-like syndrome; (6) recommendations for acute management of an MH-like syndrome; (7) special considerations for physically active populations; and (8) future directions for research...
April 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28430528/ecog-acrin-1308-commentary-on-a-negative-phase-ii-trial
#12
Adam S Garden, Pierre Blanchard
No abstract text is available yet for this article.
April 21, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28430512/simplifying-differential-equations-for-multiscale-feynman-integrals-beyond-multiple-polylogarithms
#13
Luise Adams, Ekta Chaubey, Stefan Weinzierl
In this Letter we exploit factorization properties of Picard-Fuchs operators to decouple differential equations for multiscale Feynman integrals. The algorithm reduces the differential equations to blocks of the size of the order of the irreducible factors of the Picard-Fuchs operator. As a side product, our method can be used to easily convert the differential equations for Feynman integrals which evaluate to multiple polylogarithms to an ϵ form.
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430496/renormalized-stress-energy-tensor-of-an-evaporating-spinning-black-hole
#14
Adam Levi, Ehud Eilon, Amos Ori, Maarten van de Meent
We provide the first calculation of the renormalized stress-energy tensor (RSET) of a quantum field in Kerr spacetime (describing a stationary spinning black hole). More specifically, we employ a recently developed mode-sum regularization method to compute the RSET of a minimally coupled massless scalar field in the Unruh vacuum state, the quantum state corresponding to an evaporating black hole. The computation is done here for the case a=0.7M, using two different variants of the method: t splitting and φ splitting, yielding good agreement between the two (in the domain where both are applicable)...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430416/a-complimentary-benzophenone-cross-linking-mass-spectrometry-photochemistry
#15
Adam Belsom, Gemma Mudd, Sven H Giese, Manfred Auer, Juri Rappsilber
Use of a heterobifunctional photoactivatable cross-linker, sulfo-SDA (diazirine), has yielded high-density data that facilitated structure modelling of individual proteins. We expand the photoactivatable chemistry toolbox here with a second reagent, sulfo-SBP (benzophenone). This further increases the density of photo-cross-linking to a factor of 20x over conventional cross-linking. Importantly, the two different photoactivatable groups display orthogonal directionality, enabling access to different protein regions, unreachable with a single cross-linker...
April 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28430314/transulnar-approach-as-an-alternative-to-transradial-approach-in-non-coronary-intervention-safety-feasibility-and-technical-factors
#16
Adam Zybulewski, Martin Edwards, Edward Kim, Francis S Nowakowski, Rahul Patel, Nora Tabori, Robert Lookstein, Aaron Fischman
PURPOSE: Transulnar access (TUA) has been shown to be an effective alternative to transradial access (TRA) for coronary intervention. This study evaluates the safety and efficacy of TUA in patients undergoing visceral interventions in the setting of contraindication to TRA. MATERIALS AND METHODS: Patients who underwent visceral interventions via ulnar approach were included in the study. Outcome variables include technical success, access site and bleeding complications...
April 13, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28430268/controlling-the-self-folding-of-a-polymer-sheet-using-a-local-heater-the-effect-of-the-polymer-heater-interface
#17
Jianxun Cui, Shanshan Yao, Qijin Huang, John G M Adams, Yong Zhu
Self-folding of a pre-strained shape memory polymer (SMP) sheet was demonstrated using local joule heating. Folding is caused by shrinkage variation across the thickness of the SMP sheet. The folding direction can be controlled by the interfacial interaction between the heater and the SMP sheet. When the heater is placed on the SMP sheet with no constraint (weak interface), the SMP sheet folds toward the heater. Temperature gradient across the SMP thickness gives rise to the shrinkage variation. By contrast, when the heater is fixed to the SMP sheet (strong interface), the SMP sheet can fold away from the heater...
April 21, 2017: Soft Matter
https://www.readbyqxmd.com/read/28430245/operation-of-ho-yag-ultrafast-laser-inscribed-waveguide-lasers
#18
Sean McDaniel, Fiona Thorburn, Adam Lancaster, Ronald Stites, Gary Cook, Ajoy Kar
We report fabrication and operation of multi-watt level waveguide lasers utilizing holmium-doped yttrium aluminum garnet (Ho:YAG). The waveguides were fabricated using ultrafast laser inscription, which relies on a chirped pulse ytterbium fiber laser to create depressed cladding structures inside the material. A variety of waveguides were created inside the Ho:YAG samples. We demonstrate output powers of ∼2  W from both a single-mode 50 μm waveguide laser and a multimode 80 μm waveguide laser. In addition, laser action from a co-doped Yb:Ho:YAG sample under in-band pumping conditions was demonstrated...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28429970/taking-data-seriously-the-value-of-actor-network-theory-in-rethinking-patient-experience-data
#19
Amit Desai, Giulia Zoccatelli, Mary Adams, Davina Allen, Sally Brearley, Anne Marie Rafferty, Glenn Robert, Sara Donetto
Hospitals are awash with patient experience data, much of it collected with the ostensible purpose of improving the quality of patient care. However, there has been comparatively little consideration of the nature and capacities of data itself. Using insights from actor-network theory, we propose that paying attention to patient experience data as having agency in particular hospital interactions allows us to better trace how and in what circumstances data lead (or fail to lead) to quality improvement.
April 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/28429878/a-systematic-review-of-ultrasound-imaging-as-a-tool-for-evaluating-haemophilic-arthropathy-in-children-and-adults
#20
REVIEW
C C Ligocki, A Abadeh, K C Wang, T Adams-Webber, V S Blanchette, A S Doria
The purpose of this study was to semi-quantitatively assess the evidence on the value of ultrasound (US) for assessment of haemophilic arthropathy (HA) in children and adults based on the following questions: (1) Does early diagnosis of pathological findings, using available US techniques, impact the functional status of the joint? (2) Do current available US techniques have the ability to accurately detect pathological changes in target joints in haemophilic patients? (3) Does treatment (prophylaxis) improve US evidence of haemophilic arthropathy in children and adults? (4) Is there any association between various US scoring systems and other clinical/radiological constructs? Of the 6880 citations identified searching databases such as MEDLINE, Embase, CENTRAL and Web of Science, 20 articles investigating either the diagnostic accuracy of US and/or US scanning protocols and scoring systems for assessment of HA met the inclusion criteria for the study...
April 21, 2017: Haemophilia: the Official Journal of the World Federation of Hemophilia
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