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https://www.readbyqxmd.com/read/29667864/exploring-nurse-leaders-policy-participation-within-the-context-of-a-nursing-conceptual-framework
#1
Ashley Waddell, Jeffrey M Adams, Jacqueline Fawcett
This study was designed to describe and quantify the experiences of nurse leaders working to influence policy and to build consensus for priority skills and knowledge useful in policy efforts within the context of a nursing conceptual framework. The conceptual model for nursing and health policy and the Adams influence model were combined into a conceptual framework used to guide this two-round modified Delphi study. Twenty-two nurse leaders who were members of a state action coalition participated in the Round 1 focus group; 15 of these leaders completed the Round 2 electronic survey...
January 1, 2018: Policy, Politics & Nursing Practice
https://www.readbyqxmd.com/read/29667579/intracellular-antibody-signalling-is-regulated-by-phosphorylation-of-the-fc-receptor-trim21
#2
Claire Dickson, Adam J Fletcher, Marina Vaysburd, Ji-Chun Yang, Donna L Mallery, Jingwei Zeng, Christopher M Johnson, Stephen H McLaughlin, Mark Skehel, Sarah Maslen, James Cruickshank, Nicolas Huguenin-Dezot, Jason W Chin, David Neuhaus, Leo C James
Cell surface Fc receptors activate inflammation and are tightly controlled to prevent autoimmunity. Antibodies also simulate potent immune signalling from inside the cell via the cytosolic antibody receptor TRIM21, but how this is regulated is unknown. Here we show that TRIM21 signalling is constitutively repressed by its B-Box domain and activated by phosphorylation. The B-Box occupies an E2 binding site on the catalytic RING domain by mimicking E2-E3 interactions, inhibiting TRIM21 ubiquitination and preventing immune activation...
April 18, 2018: ELife
https://www.readbyqxmd.com/read/29667576/case-of-seasonal-reassortant-a-h1n2-influenza-virus-infection-the-netherlands-march-2018
#3
Adam Meijer, Corien M Swaan, Martin Voerknecht, Edin Jusic, Sharon van den Brink, Lisa A Wijsman, Bettie Cg Voordouw, Gé A Donker, Jacqueline Sleven, Wendelien W Dorigo-Zetsma, Sanela Svraka, Michiel van Boven, Manon R Haverkate, Aura Timen, Jaap T van Dissel, Marion Pg Koopmans, Theo M Bestebroer, Ron Am Fouchier
A seasonal reassortant A(H1N2) influenza virus harbouring genome segments from seasonal influenza viruses A(H1N1)pdm09 (HA and NS) and A(H3N2) (PB2, PB1, PA, NP, NA and M) was identified in March 2018 in a 19-months-old patient with influenza-like illness (ILI) who presented to a general practitioner participating in the routine sentinel surveillance of ILI in the Netherlands. The patient recovered fully. Further epidemiological and virological investigation did not reveal additional cases.
April 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29667497/how-do-contextual-factors-influence-implementation-and-receipt-of-positive-youth-development-programs-addressing-substance-use-and-violence-a-qualitative-meta-synthesis-of-process-evaluations
#4
Kelly Dickson, G J Melendez-Torres, Adam Fletcher, Kate Hinds, James Thomas, Claire Stansfield, Simon Murphy, Rona Campbell, Chris Bonell
OBJECTIVE: Positive youth development (PYD) often aims to prevent tobacco, alcohol, and drugs use and violence. We systematically reviewed PYD interventions, synthesizing process, and outcomes evidence. Synthesis of outcomes, published elsewhere, found no overall evidence of reducing substance use or violence but notable variability of fidelity. Our synthesis of process evaluations examined how implementation varied and was influenced by context. DATA SOURCE: Process evaluations of PYD aiming to reduce substance use and violence...
May 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29667483/global-epidemiology-of-serogroup-b-meningococcal-disease-and-opportunities-for-prevention-with-novel-recombinant-protein-vaccines
#5
Rodolfo Villena, Marco Aurelio P Safadi, María Teresa Valenzuela, Juan P Torres, Adam Finn, Miguel O'Ryan
Meningococcal disease (MD) is a major cause of meningitis and sepsis worldwide, with a high case fatality rate and frequent sequelae. Neisseria meningitidis serogroups A, B, C, W, X and Y are responsible for most of these life-threatening infections, and its unpredictable epidemiology can cause outbreaks in communities, with significant health, social and economic impact. Currently, serogroup B is the main cause of MD in Europe and North America and one of the most prevalent serogroups in Latin America. Mass vaccination strategies using polysaccharide vaccines have been deployed since the 1970s and the use of conjugate vaccines has controlled endemic and epidemic disease caused by serogroups A, C, W and Y and more recently serogroup B using geographically-specific outer membrane vesicle based vaccines...
April 18, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29667429/quadriceps-function-knee-pain-and-self-reported-outcomes-in-patients-with-anterior-cruciate-ligament-reconstruction
#6
Adam S Lepley, Brian Pietrosimone, Marc L Cormier
CONTEXT:   Interactions among muscle strength, pain, and self-reported outcomes in patients with anterior cruciate ligament reconstruction (ACLR) are not well understood. Clarifying these interactions is of clinical importance because improving physical and psychological function is thought to optimize outcomes after ACLR. OBJECTIVE:   To examine the relationships among neuromuscular quadriceps function, pain, self-reported knee function, readiness to return to activity, and emotional response to injury both before and after ACLR...
April 18, 2018: Journal of Athletic Training
https://www.readbyqxmd.com/read/29667229/uc-1v150-a-potent-tlr7-agonist-capable-of-activating-macrophages-and-potentiating-mab-mediated-target-cell-deletion
#7
Lekh N Dahal, Adam Gadd, Alexander D Edwards, Mark S Cragg, Stephen A Beers
Toll like receptors (TLR) are critical mediators of the immune system with their activation linked to infection, inflammation and the pathogenesis of immune diseases including autoimmunity and cancer. For this reason, over the last two decades, TLR and their associated signalling pathways have been targeted therapeutically to enhance innate and adaptive immunity. Several TLR ligands, both endogenous and synthetic are at various phases of clinical testing, and new ligands are continually emerging. Agonists of TLR7 are known immune response modifiers, simultaneously stimulating several cell types, resulting in immune cell activation and cytokine and chemokine release...
April 18, 2018: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/29667154/reliability-and-feasibility-of-gait-initiation-centre-of-pressure-excursions-using-a-wii-%C3%A2-balance-board-in-older-adults-at-risk-of-failing
#8
James Lee, Graham Webb, Adam P Shortland, Rebecca Edwards, Charlotte Wilce, Gareth D Jones
BACKGROUND: Impairments in dynamic balance have a detrimental effect in older adults at risk of falls (OARF). Gait initiation (GI) is a challenging transitional movement. Centre of pressure (COP) excursions using force plates have been used to measure GI performance. The Nintendo Wii Balance Board (WBB) offers an alternative to a standard force plate for the measurement of CoP excursion. AIMS: To determine the reliability of COP excursions using the WBB, and its feasibility within a 4-week strength and balance intervention (SBI) treating OARF...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667116/intraoperative-pancreatic-cancer-detection-using-tumor-specific-multimodality-molecular-imaging
#9
Willemieke S Tummers, Sarah E Miller, Nutte T Teraphongphom, Adam Gomez, Idan Steinberg, David M Huland, Steve Hong, Sri-Rajasekhar Kothapalli, Alifia Hasan, Robert Ertsey, Bert A Bonsing, Alexander L Vahrmeijer, Rutger-Jan Swijnenburg, Teri A Longacre, George A Fisher, Sanjiv S Gambhir, George A Poultsides, Eben L Rosenthal
BACKGROUND: Operative management of pancreatic ductal adenocarcinoma (PDAC) is complicated by several key decisions during the procedure. Identification of metastatic disease at the outset and, when none is found, complete (R0) resection of primary tumor are key to optimizing clinical outcomes. The use of tumor-targeted molecular imaging, based on photoacoustic and fluorescence optical imaging, can provide crucial information to the surgeon. The first-in-human use of multimodality molecular imaging for intraoperative detection of pancreatic cancer is reported using cetuximab-IRDye800, a near-infrared fluorescent agent that binds to epidermal growth factor receptor...
April 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29667071/optimizing-cardiac-resynchronization-therapy-an-update-on-new-insights-and-advancements
#10
REVIEW
Adam Grimaldi, Eiran Z Gorodeski, John Rickard
PURPOSE OF REVIEW: This review focuses on the current advancements in optimizing patient response to cardiac resynchronization therapy (CRT). RECENT FINDINGS: It has been well known that not every patient will derive benefit from CRT, and of those that do, there are varying levels of response. Optimizing CRT begins well before device implant and involves appropriate patient selection and an understanding of the underlying substrate. After implant, there are different CRT device programming options that can be enabled to help overcome barriers as to why a patient may not respond...
April 17, 2018: Current Heart Failure Reports
https://www.readbyqxmd.com/read/29667035/hatching-delays-in-great-tits-and-blue-tits-in-response-to-an-extreme-cold-spell-a-long-term-study
#11
Michał Glądalski, Mirosława Bańbura, Adam Kaliński, Marcin Markowski, Joanna Skwarska, Jarosław Wawrzyniak, Piotr Zieliński, Jerzy Bańbura
Variation in ambient temperature affects various life stages of organisms. It has been suggested that climate change not only implies higher global temperatures but also more unpredictable weather and more frequent extreme weather events. Temperature has a major influence on the optimal laying-incubation-hatching dates of insectivorous passerines, because it poses energetic constraints and affects the timing of food abundance. We have been studying breeding characteristics of great tits Parus major and blue tits Cyanistes caeruleus in two areas, an urban parkland and a deciduous forest, around the city of Łódź since 2002...
April 17, 2018: International Journal of Biometeorology
https://www.readbyqxmd.com/read/29666860/fluorescence-imaging-of-antibiotic-clofazimine-encapsulated-within-mesoporous-silica-particle-carriers-relevance-to-drug-delivery-and-the-effect-on-its-release-kinetics
#12
Lorenzo Angiolini, Sabrina Valetti, Boiko Cohen, Adam Feiler, Abderrazzak Douhal
We report on the encapsulation of the antibiotic clofazimine (CLZ) within the pores of mesoporous silica particles having hydrophilic (CBET value of 137) and more hydrophobic (CBET value of 94 after calcination at 600 °C) surfaces. We studied the effect of pH on the released amount of CLZ in aqueous solutions and observed a maximum at pH 4.1 in correlation with the solubility of the drug. Less release of the drug was observed from the more hydrophobic particles which was attributed to a difference in the affinity of the drug to the carrier particles...
April 18, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29666818/the-role-of-positron-emission-tomography-in-the-diagnosis-staging-and-response-assessment-of-non-small-cell-lung-cancer
#13
REVIEW
Sara Volpi, Jason M Ali, Angela Tasker, Adam Peryt, Giuseppe Aresu, Aman S Coonar
Lung cancer is a common disease and the leading cause of cancer-related mortality, with non-small cell lung cancer (NSCLC) accounting for the majority of cases. Following diagnosis of lung cancer, accurate staging is essential to guide clinical management and inform prognosis. Positron emission tomography (PET) in conjunction with computed tomography (CT)-as PET-CT has developed as an important tool in the multi-disciplinary management of lung cancer. This article will review the current evidence for the role of 18 F-fluorodeoxyglucose (FDG) PET-CT in NSCLC diagnosis, staging, response assessment and follow up...
March 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29666750/tweet-success-scientific-communication-correlates-with-increased-citations-in-ecology-and-conservation
#14
Clayton T Lamb, Sophie L Gilbert, Adam T Ford
Science communication is seen as critical for the disciplines of ecology and conservation, where research products are often used to shape policy and decision making. Scientists are increasing their online media communication, via social media and news. Such media engagement has been thought to influence or predict traditional metrics of scholarship, such as citation rates. Here, we measure the association between citation rates and the Altmetric Attention Score-an indicator of the amount and reach of the attention an article has received-along with other forms of bibliometric performance (year published, journal impact factor, and article type)...
2018: PeerJ
https://www.readbyqxmd.com/read/29666598/memory-specificity-training-for-depression-and-posttraumatic-stress-disorder-a-promising-therapeutic-intervention
#15
Mina N Erten, Adam D Brown
No abstract text is available yet for this article.
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29666395/author-correction-facile-emulsion-mediated-synthesis-of-phase-pure-diopside-nanoparticles
#16
Elena Tajuelo Rodriguez, Lawrence M Anovitz, Caleb D Clement, Adam J Rondinone, Michael C Cheshire
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29666306/truncation-and-motif-based-pan-cancer-analysis-reveals-tumor-suppressing-kinases
#17
Andrew M Hudson, Natalie L Stephenson, Cynthia Li, Eleanor Trotter, Adam J Fletcher, Gitta Katona, Patrycja Bieniasz-Krzywiec, Matthew Howell, Chris Wirth, Simon Furney, Crispin J Miller, John Brognard
A major challenge in cancer genomics is identifying "driver" mutations from the many neutral "passenger" mutations within a given tumor. To identify driver mutations that would otherwise be lost within mutational noise, we filtered genomic data by motifs that are critical for kinase activity. In the first step of our screen, we used data from the Cancer Cell Line Encyclopedia and The Cancer Genome Atlas to identify kinases with truncation mutations occurring within or before the kinase domain...
April 17, 2018: Science Signaling
https://www.readbyqxmd.com/read/29666269/worldwide-distribution-of-the-dcdc2-read1-regulatory-element-and-its-relationship-with-phoneme-variation-across-languages
#18
Mellissa M C DeMille, Kevin Tang, Chintan M Mehta, Christopher Geissler, Jeffrey G Malins, Natalie R Powers, Beatrice M Bowen, Andrew K Adams, Dongnhu T Truong, Jan C Frijters, Jeffrey R Gruen
DCDC2 is a gene strongly associated with components of the phonological processing system in animal models and in multiple independent studies of populations and languages. We propose that it may also influence population-level variation in language component usage. To test this hypothesis, we investigated the evolution and worldwide distribution of the READ1 regulatory element within DCDC2 , and compared its distribution with variation in different language properties. The mutational history of READ1 was estimated by examining primate and archaic hominin sequences...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29666163/neurodevelopmental-impairment-among-extremely-preterm-infants-in-the-neonatal-research-network
#19
Ira Adams-Chapman, Roy J Heyne, Sara B DeMauro, Andrea F Duncan, Susan R Hintz, Athina Pappas, Betty R Vohr, Scott A McDonald, Abhik Das, Jamie E Newman, Rosemary D Higgins
OBJECTIVES: Evaluate the spectrum of neurodevelopmental outcome in a contemporary cohort of extremely preterm infants. We hypothesize that the rate of severe neurodevelopmental impairment (NDI) decreases over time. METHODS: Retrospective analysis of neurodevelopmental outcome of preterm infants ≤27 weeks' gestational age (GA) from a Neonatal Research Network center that completed neurodevelopmental follow-up assessments between April 1, 2011, and January 1, 2015...
April 17, 2018: Pediatrics
https://www.readbyqxmd.com/read/29666136/systematic-review-and-meta-analysis-of-diabetes-mellitus-cardiovascular-and-respiratory-condition-epidemiology-in-sexual-minority-women
#20
Catherine Meads, Adam Martin, Jeffrey Grierson, Justin Varney
OBJECTIVE: Sexual minority women (SMW) experience higher chronic disease risk factors than heterosexual counterparts. However, it was unclear if these risks translate into higher physical condition rates. This systematic review evaluates cardiovascular disease (CVD), hypertension, respiratory disease and diabetes mellitus in SMW. METHODS: A protocol was registered with the Prospero database (CRD42016050299). Included were studies reporting mortality, incidence or prevalence of the above-listed conditions in SMW compared with heterosexual women...
April 17, 2018: BMJ Open
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