keyword
MENU ▼
Read by QxMD icon Read
search

Angiotensin converting enzyme

keyword
https://www.readbyqxmd.com/read/29656575/experimental-and-clinical-antihypertensive-activity-of-matricaria-chamomilla-extracts-and-their-angiotensin-converting-enzyme-inhibitory-activity
#1
Amani A Awaad, Reham M El-Meligy, Ghada M Zain, Amal A Safhi, Noura A Al Qurain, Shekhah S Almoqren, Yara M Zain, Vidya D Sesh Adri, Fahad I Al-Saikhan
Three different extracts of Matricaria chamomilla L. were evaluated for their antihypertensive activity, these extracts were total alcohol extract (Extract 1), oil extracted (Extract 2), and water lifted after oil extraction (Extract 3). Quantitative and Qualitative analyses were carried out for all extracts. The 3 extracts were proved to be safe for human use. A single oral administration of the plant extracts (200 mg/kg) decreases both systolic and diastolic blood pressure of normotensive rats after 1, 1...
April 15, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29656391/proteomic-analysis-of-sperm-proteins-in-infertile-men-with-high-levels-of-reactive-oxygen-species
#2
A Ayaz, A Agarwal, R Sharma, N Kothandaraman, Z Cakar, S Sikka
Oxidative stress is a significant risk factor for male infertility. A pro-oxidant testicular environment may alter the expression profile of functional sperm proteins and result in poor sperm quality. Patients and donors were divided into ROS (-) and ROS (+) groups. Using computational studies, and data mining of available literature on spermatozoa, oxidative stress and proteomics, we identified three core regulatory proteins angiotensin-converting enzyme (ACE), heat-shock protein (Hsp70) family A member 2 (HSPA2) and ribosomal protein subunit 27A (RPS27A) and seven interlink proteins NOS2, SUMO2, UBL4A, FBXO25, MAP3K3, APP and UBC...
April 15, 2018: Andrologia
https://www.readbyqxmd.com/read/29652176/medication-use-in-women-and-men-with-sudden-unexpected-death
#3
Sonalie Patel, Mitchell M Conover, Golsa Joodi, Sarah Chen, Ross J Simpson, Zachariah M Deyo
BACKGROUND: In Wake County, NC, sudden unexpected death accounts for 10% to 15% of all natural deaths in individuals 18 to 64 years old. Medications such as aspirin, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, statins, and β-blockers are recommended in guidelines to reduce cardiovascular events and even sudden death (β-blockers). However, guidelines are often underpracticed, even in high-risk patients, with noted disparities in women. OBJECTIVE: We assessed the relation between prescription of evidence-based medications and sudden unexpected death in Wake County, NC...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29652095/decrease-in-neprilysin-and-vasoconstrictors-and-increase-in-vasodilators-following-bariatric-surgery
#4
Husam Ghanim, Scott Monte, Joseph Caruana, Kelly Green, Sanaa Abuaysheh, Paresh Dandona
Since morbid obesity is associated with congestive cardiac failure and hypertension, and gastric bypass surgery is followed by a reduction in blood pressure and in the risk of congestive cardiac failure, we hypothesized that weight loss following Roux-en-Y gastric bypass (RYGB) surgery in morbidly obese patients is associated with a decrease in plasma concentrations of neprilysin, mediators of renin angiotensin system (RAS), catecholamines and endothelin-1 with an increase in the concentrations of vasodilators...
April 13, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29650709/machine-learning-methods-improve-prognostication-identify-clinically-distinct-phenotypes-and-detect-heterogeneity-in-response-to-therapy-in-a-large-cohort-of-heart-failure-patients
#5
Tariq Ahmad, Lars H Lund, Pooja Rao, Rohit Ghosh, Prashant Warier, Benjamin Vaccaro, Ulf Dahlström, Christopher M O'Connor, G Michael Felker, Nihar R Desai
BACKGROUND: Whereas heart failure (HF) is a complex clinical syndrome, conventional approaches to its management have treated it as a singular disease, leading to inadequate patient care and inefficient clinical trials. We hypothesized that applying advanced analytics to a large cohort of HF patients would improve prognostication of outcomes, identify distinct patient phenotypes, and detect heterogeneity in treatment response. METHODS AND RESULTS: The Swedish Heart Failure Registry is a nationwide registry collecting detailed demographic, clinical, laboratory, and medication data and linked to databases with outcome information...
April 12, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29644219/management-of-chemotherapy-induced-left-ventricular-dysfunction-and-heart-failure-in-patients-with-cancer-while-undergoing-cancer-treatment-the-md-anderson-practice
#6
Anecita P Fadol
Chemotherapy-induced cardiotoxicity resulting in heart failure (HF) is one of the most dreaded complications of cancer therapy that can significantly impact morbidity and mortality. With a high prevalence of cardiovascular disease in cancer patients, the risk of developing HF is significantly increased. A new discipline of Onco-Cardiology has evolved to address the cardiovascular needs of patients with cancer, however, there is limited evidence-based data to guide clinical decision-making in the management of the cardiovascular complications of cancer therapy...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29643067/incidence-predictors-and-outcomes-associated-with-hypotensive-episodes-among-heart-failure-patients-receiving-sacubitril-valsartan-or-enalapril-the-paradigm-hf-trial-prospective-comparison-of-angiotensin-receptor-neprilysin-inhibitor-with-angiotensin-converting
#7
Orly Vardeny, Brian Claggett, Jessica Kachadourian, Scott M Pearson, Akshay S Desai, Milton Packer, Jean Rouleau, Michael R Zile, Karl Swedberg, Martin Lefkowitz, Victor Shi, John J V McMurray, Scott D Solomon
BACKGROUND: In PARADIGM-HF (Prospective Comparison of Angiotensin Receptor Neprilysin Inhibitor With Angiotensin-Converting Enzyme Inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure), heart failure treatment with sacubitril/valsartan reduced the primary composite outcome of cardiovascular death or heart failure hospitalization compared with enalapril but resulted in more symptomatic hypotension. Concern on hypotension may be limiting use of sacubitril/valsartan in appropriate patients...
April 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29629833/aerobic-exercise-training-differentially-affects-ace-c-and-n-domain-activities-in-humans-interactions-with-ace-i-d-polymorphism-and-association-with-vascular-reactivity
#8
Cléber Rene Alves, Tiago Fernandes, José Ribeiro Lemos, Flávio de Castro Magalhães, Ivani Credidio Trombetta, Guilherme Barreto Alves, Glória de Fátima Alves da Mota, Rodrigo Gonçalves Dias, Alexandre Costa Pereira, José Eduardo Krieger, Carlos Eduardo Negrão, Edilamar Menezes Oliveira
INTRODUCTION: Previous studies have linked angiotensin-converting enzyme ( ACE) insertion (I)/deletion (D) polymorphism (II, ID and DD) to physical performance. Moreover, ACE has two catalytic domains: NH2 (N) and COOH (C) with distinct functions, and their activity has been found to be modulated by ACE polymorphism. The aim of the present study is to investigate the effects of the interaction between aerobic exercise training (AET) and ACE I/D polymorphism on ACE N- and C-domain activities and vascular reactivity in humans...
April 2018: Journal of the Renin-angiotensin-aldosterone System: JRAAS
https://www.readbyqxmd.com/read/29628190/prognostic-utility-of-initial-lactate-in-patients-with-acute-drug-overdose-a-validation-cohort
#9
Randy Cheung, Robert S Hoffman, David Vlahov, Alex F Manini
STUDY OBJECTIVE: Previous studies have suggested that the initial emergency department (ED) lactate concentration may be an important prognostic indicator for inhospital mortality from acute drug poisoning. We conduct this cohort study to formally validate the prognostic utility of the initial lactate concentration in a larger, distinct patient population with acute drug overdose. METHODS: This observational, prospective, cohort study was conducted during 5 years at 2 urban teaching hospitals...
April 6, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29627490/genetically-determined-enlargement-of-carotid-body-evaluated-using-computed-angiotomography
#10
Przemysław Jaźwiec, Paweł Gać, Monika Chaszczewska-Markowska, Katarzyna Bogunia-Kubik, Grzegorz Mazur, Rafał Poręba
It has recently been established that carotid bodies play a significant role in the regulation of activities of the cardiovascular system as well as in the pathogenesis of arterial hypertension, heart failure and diabetes. Aim of study was to determinate the influence of polymorphisms within genes of the renin-angiotensin-aldosterone system (RAAS) on the volume of the carotid bodies (CB) in patients with hypertension (HTA). The study group consisted of 77 patients with HTA. All patients were genotyped for single-nucleotide polymorphisms of genes coding for: angiotensinogen: rs4762, rs5049, rs5051 and rs699; angiotensin-converting enzyme: rs4343; angiotensin receptor type 1 gene (AGTR1): rs5182 and rs5186; and the aldosterone synthase: rs1799998...
April 5, 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29626018/drug-therapies-in-chronic-heart-failure-a-focus-on-reduced-ejection-fraction
#11
Helena Bolam, Geraint Morton, Paul R Kalra
There are multiple evidence-based drug treatments for chronic heart failure (HF), both disease-modifying agents and those for symptom control. The majority of the evidence base supports drugs used in HF with reduced left ventricular ejection fraction. The mainstay of disease modification involves manipulation of neurohormonal activation that occurs in HF. In addition to established angiotensin-converting enzyme inhibitors, beta blockers and mineralocorticoid receptor antagonists (MRAs), newer agents are now available such as the angiotensin receptor neprilysin inhibitors...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29625513/trends-characteristics-and-clinical-outcomes-of-patients-undergoing-percutaneous-coronary-intervention-in-korea-between-2011-and-2015
#12
Seungbong Han, Gyung Min Park, Yong Giun Kim, Mahn Won Park, Sung Ho Her, Seung Whan Lee, Young Hak Kim
BACKGROUND AND OBJECTIVES: We sought to evaluate nationwide trends, characteristics, and clinical outcomes in patients undergoing percutaneous coronary intervention (PCI) in Korea. METHODS: From National Health Insurance claims data in Korea, 81,115 patients, who underwent PCI for the first episode of coronary artery disease between 2011 and 2015, were enrolled. Patients were categorized into angina (n=49,288) or acute myocardial infarction (AMI, n=31,887) groups and analyzed...
April 2018: Korean Circulation Journal
https://www.readbyqxmd.com/read/29624095/external-validation-of-the-diabetes-early-readmission-risk-indicator-derri-%C3%A2
#13
Daniel J Rubin, Dominic Recco, Alexander Turchin, Huaqing Zhao, Sherita Hill Golden
OBJECTIVE: The Diabetes Early Readmission Risk Indicator (DERRI™ ) was previously developed and internally validated as a tool to predict the risk of all-cause readmission within 30 days of discharge (30-d readmission) of hospitalized patients with diabetes. In this study, the predictive performance of the DERRI™ with and without additional predictors was assessed in an external sample. METHODS: We conducted a retrospective cohort study of adult patients with diabetes discharged from 2 academic medical centers between 1/1/2000 and 12/31/2014...
April 6, 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29623471/chronic-captopril-treatment-reveals-the-role-of-ang-ii-in-cardiovascular-function-of-embryonic-american-alligators-alligator-mississippiensis
#14
Casey A Mueller, John Eme, Kevin B Tate, Dane A Crossley
Angiotensin II (ANG II) is a powerful vasoconstrictor of the renin-angiotensin system (RAS) that plays an important role in cardiovascular regulation in adult and developing vertebrates. Knowledge of ANG II's contribution to developmental cardiovascular function comes from studies in fetal mammals and embryonic chickens. This is the first study to examine the role of ANG II in cardiovascular control in an embryonic reptile, the American alligator (Alligator mississippiensis). Using chronic low (~ 5-mg kg embryo-1 ), or high doses (~ 450-mg kg embryo-1 ) of captopril, an angiotensin-converting enzyme (ACE) inhibitor, we disrupted the RAS and examined the influence of ANG II in cardiovascular function at 90% of embryonic development...
April 6, 2018: Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology
https://www.readbyqxmd.com/read/29622220/individual-contributions-of-savinase-and-lactobacillus-plantarum-to-lentil-functionalization-during-alkaline-ph-controlled-fermentation
#15
Sara Bautista-Expósito, Elena Peñas, Montserrat Dueñas, José Manuel Silván, Juana Frias, Cristina Martínez-Villaluenga
Legumes offer the possibility to develop multifunctional foods with benefits for metabolic syndrome. Our objective was to study the effect of alkaline fermentation by Lactobacillus plantarum and Savinase (FLPS) as well the individual effects of both processes on peptides, phenolics and bioactivity of lentil. FLPS increased peptides and some flavonoids and enhanced antioxidant activity, inhibition of angiotensin I-converting enzyme (ACE) and intestinal maltase activities of lentil soluble fraction. Savinase contributed to peptide release, ACE inhibitory and antioxidant activities of lentil soluble fraction...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29620193/influence-of-the-interaction-between-ac%C3%A2-sdkp-and-ang-ii-on-the-pathogenesis-and-development-of-silicotic-fibrosis
#16
Yi Zhang, Fang Yang, Yan Liu, Hai-Bing Peng, Yu-Cong Geng, Shi-Feng Li, Hong Xu, Li-Yan Zhu, Xiu-Hong Yang, Darrell Brann
N‑acetyl‑seryl‑aspartyl‑lysyl‑proline (Ac‑SDKP) is a natural tetrapeptide that is released from thymosin β4 by prolyl oligopeptides. It is hydrolyzed by the key enzyme of the renin‑angiotensin system, angiotensin‑converting enzyme (ACE). The aim of the present study was to investigate the alterations in Ac‑SDKP and the ACE/angiotensin II (Ang II)/angiotensin II type 1 (AT1) receptor axis and its impact on the pathogenesis and development of silicotic fibrosis. For in vivo studies, a HOPE MED 8050 exposure control apparatus was used to establish different stages of silicosis in a rat model treated with Ac‑SDKP...
March 29, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29616222/does-a-better-perfusion-of-deconditioned-muscle-tissue-release-chronic-low-back-pain
#17
Paola Valdivieso, Martino V Franchi, Christian Gerber, Martin Flück
Non-specific chronic low back pain (nsCLBP) is a multifactorial condition of unknown etiology and pathogenesis. Physical and genetic factors may influence the predisposition of individuals to CLBP, which in many instances share a musculoskeletal origin. A reduced pain level in low back pain patients that participate in exercise therapy highlights that disuse-related muscle deconditioning may predispose individuals to nsCLBP. In this context, musculoskeletal pain may be the consequence of capillary rarefaction in inactive muscle as this would lower local tissue drainage and washing out of toxic waste...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29616179/expression-and-localization-of-cathepsins-b-d-and-g-in-dupuytren-s-disease
#18
Kirin Tan, Helen D Brasch, Bede van Schaijik, James R Armstrong, Reginald W Marsh, Paul F Davis, Swee T Tan, Tinte Itinteang
Background: The pathogenesis of Dupuytren's disease (DD) remains unclear. An embryonic stem cell (ESC)-like population in the endothelium of the microvessels around tissues that expresses components of the renin-angiotensin system (RAS) has been reported. This study investigated if this primitive population expresses cathepsins B, D, and G, that contribute to RAS bypass loops. Methods: 3,3-Diaminobenzidine immunohistochemical (IHC) staining for cathepsins B, D, and G was performed on sections of formalin-fixed paraffin-embedded DD cords (n = 10) and nodules (n = 10)...
February 2018: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/29615742/systemic-and-specific-effects-of-antihypertensive-and-lipid-lowering-medication-on-plasma-protein-biomarkers-for-cardiovascular-diseases
#19
Stefan Enroth, Varun Maturi, Malin Berggrund, Sofia Bosdotter Enroth, Aristidis Moustakas, Åsa Johansson, Ulf Gyllensten
A large fraction of the adult population is on lifelong medication for cardiovascular disorders, but the metabolic consequences are largely unknown. This study determines the effects of common anti-hypertensive and lipid lowering drugs on circulating plasma protein biomarkers. We studied 425 proteins in plasma together with anthropometric and lifestyle variables, and the genetic profile in a cross-sectional cohort. We found 8406 covariate-protein associations, and a two-stage GWAS identified 17253 SNPs to be associated with 109 proteins...
April 3, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29614743/protective-effect-of-polyphenol-rich-extract-from-bee-pollen-in-a-high-fat-diet
#20
Anna Rzepecka-Stojko, Agata Kabała-Dzik, Robert Kubina, Krzysztof Jasik, Maciej Kajor, Dorota Wrześniok, Jerzy Stojko
We have studied a preventive effect of polyphenol-rich bee pollen ethanol extract (EEP) against histological changes in the liver and cardiac blood vessels, abnormalities of lipid profile, and the levels of oxidized low density lipoproteins (ox-LDL), asymmetric dimethylarginine (ADMA), angiotensin-converting enzyme (ACE), and angiotensin II (ANG II) caused by a high-fat diet in C57 BL₆ mice. Supplementing the diet with EEP in the doses of 0.1 g/kg body mass (BM) and 1 g/kg BM resulted in a decrease of total cholesterol by 31% and 35%, respectively...
March 31, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
83368
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"