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https://www.readbyqxmd.com/read/28647242/effect-of-oxide-nanoparticles-on-the-morphology-and-fluidity-of-phospholipid-membranes-and-the-role-of-hydrogen-bonds
#1
Xiaoran Wei, Junchao Yu, Lei Ding, Jingtian Hu, Wei Jiang
Engineered oxide nanoparticles (NPs) are widely applied in insulators, catalyzers, paints, cosmetic products, textiles and semiconductors. Their attachment on cell membrane may lead to cytotoxicity. The effects of Al2O3, Fe2O3, SiO2, TiO2 and ZnO NPs on membrane integrity and fluidity were studied using giant or small unilamellar vesicles in this study. Al2O3 and SiO2 NPs disrupted the oppositely charged membrane, indicating the important role of electrostatic attraction. However, Fe2O3, TiO2 and ZnO NPs did not cause serious membrane disruption as Al2O3 and SiO2 NPs...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28647227/in-vivo-cellular-reactions-to-different-biomaterials-physiological-and-pathological-aspects-and-their-consequences
#2
REVIEW
Sarah Al-Maawi, Anna Orlowska, Robert Sader, C James Kirkpatrick, Shahram Ghanaati
Biomaterials are widely used in guided bone regeneration (GBR) and guided tissue regeneration (GTR). After application, there is an interaction between the host immune system and the implanted biomaterial, leading to a biomaterial-specific cellular reaction. The present review focuses on cellular reactions to numerous biomaterials in vivo with consideration of different implantation models and microenvironments in different species, such as subcutaneous implantation in mice and rats, a muscle model in goats and a femur model in rabbits...
June 21, 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/28646421/how-safe-and-effective-is-denosumab-for-bone-giant-cell-tumour
#3
REVIEW
Costantino Errani, Shinji Tsukamoto, Andreas F Mavrogenis
Recent clinical studies have suggested that denosumab is associated with beneficial tumour response, surgical down-staging, and reduced surgical morbidity in patients with giant cell tumour of bone. However, these studies reported results of patients still on denosumab treatment, or patients after denosumab treatment but with a short follow-up. Other studies reported that the new osseous tumour matrix and thickened cortical bone that develop with denosumab treatment does not allow the surgeon to delineate the true extent of the tumour, and probably increases the risk for local recurrence...
June 23, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28645852/g0s2-a-small-giant-controller-of-lipolysis-and-adipose-liver-fatty-acid-flux
#4
REVIEW
Xiaodong Zhang, Bradlee L Heckmann, Latoya E Campbell, Jun Liu
The discovery of adipose triglyceride lipase (ATGL) and its coactivator comparative gene identification-58 (CGI-58) provided a major paradigm shift in the understanding of intracellular lipolysis in both adipocytes and nonadipocyte cells. The subsequent discovery of G0/G1 switch gene 2 (G0S2) as a potent endogenous inhibitor of ATGL revealed a unique mechanism governing lipolysis and fatty acid (FA) availability. G0S2 is highly conserved in vertebrates, and exhibits cyclical expression pattern between adipose tissue and liver that is critical to lipid flux and energy homeostasis in these two tissues...
June 20, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28644557/selective-arterial-embolization-for-the-treatment-of-sacral-and-pelvic-giant-cell-tumor-a-systematic-review
#5
REVIEW
Shao-Hui He, Wei Xu, Zheng-Wang Sun, Wei-Bo Liu, Yu-Jie Liu, Hai-Feng Wei, Jian-Ru Xiao
Giant cell tumor of the bone (GCTB) is a locally aggressive tumor with a certain distant metastatic rate. For sacral GCT (SGCT) and pelvic GCT (PGCT), surgery has its limitations, especially for unresectable or recurrent tumors. Selective arterial embolization (SAE) is reported to be an option for treatment in several cases, but there are few systematic reviews on the effects of SAE on SGCT and/or PGCT. Medline and Embase databases were searched for eligible English articles. Inclusion and exclusion criteria were conducted before searching...
May 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28643813/-polymyalgia-rheumatica-diagnostic-and-therapeutic-issues-of-an-apparently-straightforward-disease
#6
Ciro Manzo, Dario Camellino
Polymyalgia rheumatica (PMR) is an inflammatory disease characterized by aching and stiffness in the girdles, which affects typically people over 50 years old and could overlap with giant cell arteritis (GCA) in about 15-20% of cases. Although the diagnosis of PMR is usually considered straightforward, clinicians facing this disease should be aware of its atypical manifestations, which can hamper the correct identification of PMR and, conversely, should be aware of other diseases which may present with polymyalgic features...
May 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28643220/denosumab-an-emerging-therapy-in-pediatric-bone-disorders
#7
REVIEW
Alison M Boyce
PURPOSE OF REVIEW: Denosumab is an inhibitor of receptor activator of nuclear factor kappa-B ligand (RANKL), and has emerged as an important novel therapy for skeletal disorders. This article examines the use of denosumab in children. RECENT FINDINGS: Considerable safety and efficacy data exists for denosumab treatment of adults with osteoporosis, bone metastases, and giant cell tumors. Pediatric data is limited; however, evidence suggests denosumab may be beneficial in decreasing bone turnover, increasing bone density, and preventing growth of certain skeletal neoplasms in children...
June 22, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28642770/interplay-between-carotenoids-abscisic-acid-and-jasmonate-guides-the-compatible-rice-meloidogyne-graminicola-interaction
#8
Tina Kyndt, Kamrun Nahar, Ashley Haeck, Ruben Verbeek, Kristof Demeestere, Godelieve Gheysen
In this study, we have characterized the role of carotenoids and chlorophyll in the compatible interaction between the sedentary root knot nematode (RKN) Meloidogyne graminicola and the monocot model plant rice (Oryza sativa). Previous transcriptome data showed a differential expression of carotenoid and chlorophyll biosynthesis genes in nematode-induced giant cells and gall tissue. Metabolite measurement showed that galls indeed accumulate chlorophyll a, b and carotenoids, as well as the hormone abscisic acid (ABA)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28642042/changes-in-biophysical-membrane-properties-induced-by-the-budesonide-hydroxy-%C3%AE-cyclodextrin-complex
#9
Andreia G Dos Santos, Jules Bayiha, Gilles Dufour, Didier Cataldo, Brigitte Evrard, Liana C Silva, Magali Deleu, Marie-Paule Mingeot-Leclercq
Budesonide (BUD), a poorly soluble anti-inflammatory drug, is used to treat patients suffering from asthma and COPD (Chronic Obstructive Pulmonary Disease). Hydroxypropyl-β-cyclodextrin (HPβCD), a biocompatible cyclodextrin known to interact with cholesterol, is used as a drug-solubilizing agent in pharmaceutical formulations. Budesonide administered as an inclusion complex within HPβCD (BUD:HPβCD) required a quarter of the nominal dose of the suspension formulation and significantly reduced neutrophil induced inflammation in a COPD mouse model exceeding the effect of each molecule administered individually...
June 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28641466/a-model-of-lipid-rearrangements-during-pore-formation-in-the-dppc-lipid-bilayer
#10
Artur Wrona, Krystian Kubica
CONTEXT: The molecular bases of pore formation in the lipid bilayer remain unclear, as do the exact characteristics of their sizes and distributions. To understand this process, numerous studies have been performed on model lipid membranes including cell-sized giant unilamellar vesicles (GUV). The effect of an electric field on DPPC GUV depends on the lipid membrane state: in the liquid crystalline phase the created pores have a cylinder-like shape, whereas in the gel phase a crack has been observed...
June 23, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/28641115/feature-integration-drives-probabilistic-behavior-in-the-drosophila-escape-response
#11
Catherine R von Reyn, Aljoscha Nern, W Ryan Williamson, Patrick Breads, Ming Wu, Shigehiro Namiki, Gwyneth M Card
Animals rely on dedicated sensory circuits to extract and encode environmental features. How individual neurons integrate and translate these features into behavioral responses remains a major question. Here, we identify a visual projection neuron type that conveys predator approach information to the Drosophila giant fiber (GF) escape circuit. Genetic removal of this input during looming stimuli reveals that it encodes angular expansion velocity, whereas other input cell type(s) encode angular size. Motor program selection and timing emerge from linear integration of these two features within the GF...
June 21, 2017: Neuron
https://www.readbyqxmd.com/read/28639571/recurrence-factors-in-giant-cell-tumors-of-the-spine
#12
Han-Qiang Ouyang, Liang Jiang, Xiao-Guang Liu, Feng Wei, Shao-Min Yang, Na Meng, Ping Jiang, Miao Yu, Feng-Liang Wu, Lei Dang, Hua Zhou, Hua Zhang, Zhong-Jun Liu
BACKGROUND: Giant cell tumors (GCTs) are benign, locally aggressive tumors. We examined the rate of local recurrence of spinal GCTs and sought to identify recurrence factors in patients who underwent surgery. METHODS: Between 1995 and 2014, 94 mobile spine GCT patients were treated at our hospital, comprising 43 male and 51 female patients with an average age of 33.4 years. Piecemeal intralesional spondylectomy and total en bloc spondylectomy (TES) were performed...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28639531/outcome-of-bone-recycling-using-liquid-nitrogen-as-bone-reconstruction-procedure-in-malignant-and-recurrent-benign-aggressive-bone-tumour-of-distal-tibia-a-report-of-four-cases
#13
Eka Wiratnaya I Gede, Arrisna Artha Ida Ayu, Yudhi Setiawan I Gn, Wien Aryana Ign, Suyasa I Ketut, Siki Kawiyana I Ketut, Astawa Putu
Amputation still considered as primary choice of malignancy treatment in distal tibia. Bone recycling with liquid nitrogen for reconstruction following resection of malignant bone tumours offers many advantages. We presented four patients with osteosarcoma, Ewing sarcoma, adamantinoma and recurrent giant cell tumour over distal tibia. All of the patients underwent wide excision and bone recycling using liquid nitrogen as bone reconstruction. The mean functional Musculoskeletal Tumor Society (MSTS) score was 75% with no infection and local recurrent...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28638968/-large-vessel-vasculitis-giant-cell-arteritis-and-takayasu-arteritis
#14
P M Villiger
According to the Chapel Hill Classification, large vessel vasculitides encompass giant cell arteritis (GCA) and the histologically related Takakaysu arteritis (TAK). The two diseases lack autoantibodies and present with a systemic inflammatory response. GCA typically shows a sudden onset with profound sickness, loss of appetite and of body weight, and temporal headache. Due to the substantial risk of sudden blindness, diagnostic work-up has to be performed immediately and treatment started without delay. A close association between polymyalgia rheumatica (PMR) and GCA is well established...
June 21, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28638694/giant-cell-arteritis-polymyalgia-rheumatica-and-late-onset-rheumatoid-arthritis-can-they-be-components-of-a-single-disease-process-in-elderly-patients
#15
REVIEW
Cengiz Korkmaz, Pınar Yıldız
OBJECTIVE: To report two patients with giant cell arteritis (GCA) who developed rheumatoid arthritis (RA) and to review the literature in terms of coexistence of RA, GCA, and polymyalgia rheumatica (PMR). METHODS: We conducted a comprehensive review of the English literature from 1980 to 2015 to analyze data on the coexistence of GCA and RA. The PubMed, Web of Science, Proquest, and Ovid databases were searched for articles using the term RA combined with temporal arteritis, GCA, and PMR...
June 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28637240/tfeb-activation-restores-migration-ability-to-tsc1-deficient-adult-neural-stem-progenitor-cells
#16
Alessandro Magini, Alice Polchi, Danila Di Meo, Giuseppina Mariucci, Krizia Sagini, Federico De Marco, Tommaso Cassano, Stefano Giovagnoli, Diego Dolcetta, Carla Emiliani
Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by mutations in either of two genes, TSC1 or TSC2, resulting in the constitutive activation of the mammalian target of rapamycin complex 1 (mTORC1). mTOR inhibitors are now considered the treatment of choice for TSC disease. A major pathological feature of TSC is the development of subependymal giant cell astrocytomas (SEGAs) in the brain. Nowadays, it is thought that SEGAs could be a consequence of aberrant aggregation and migration of neural stem/progenitor cells (NSPCs)...
June 14, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28633343/an-unknown-reaction-to-pembrolizumab-giant-cell-arteritis
#17
I Micaily, M Chernoff
No abstract text is available yet for this article.
June 15, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28633039/giant-cell-tumor-of-bone-with-pathological-evidence-of-blood-vessel-invasion
#18
Shadi Khalil, Rachana Yendala, Nicholas D'Cunha, Fred Hardwicke, Mohamed Shanshal
Giant cell tumor of bone is a rare but aggressive benign tumor that arises at the end of long tubular bones. The tumor rarely metastasizes; however, we report a case in which a giant cell tumor of bone presented with progressive pulmonary metastases. There has been no clear pathologic evidence of the definitive cause or route of metastasis. In our case, the primary tumor site was located in the left femur with pathological evidence of blood vessel invasion. The histological and pathological features of this entity are discussed in this letter to the editor...
June 15, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28632797/approach-to-management-of-giant-basal-cell-carcinomas
#19
Sarah E Mott, William J Hunter, Edibaldo Silva, Christopher J Huerter
Basal cell carcinoma (BCC) is a common nonmelanoma skin cancer with increasing incidence in the United States and worldwide. It is strongly linked to UV radiation exposure and typically is slow growing. Malignancy in BCCs is due to local growth and invasion rather than metastasis, and the prognosis is generally favorable. We report the case of a 60-year-old man with a large, locally destructive giant BCC on the right side of the upper back that was successfully treated via complete surgical excision (SE) and did not recur in the subsequent 36 months...
May 2017: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28630838/a-case-report-of-an-unusual-case-of-tuberculous-osteomyelitis-causing-spontaneous-pathological-fracture-of-humerus-in-a-middle-aged-female
#20
Umesh Birole, Ashish Ranade, Mahesh Mone
INTRODUCTION: Tuberculosis is a major health problem worldwide. Extrapulmonary tuberculosis is often secondary to some primary foci in lungs. There are reports of tuberculous osteomyelitis involving maxilla, ulna, femur, and shoulder joint but none have reported pathological fracture in humeral diaphysis due to tuberculosis osteomyelitis without shoulder joint involvement. We report a case of pathological fracture of humerus diaphysis due to tuberculous osteomyelitis with normal articular space...
January 2017: Journal of Orthopaedic Case Reports
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