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https://www.readbyqxmd.com/read/29345352/achyranthes-bidentata-polysaccharide-suppresses-osteoclastogenesis-and-bone-resorption-via-inhibiting-rankl-signaling
#1
Dezhi Song, Zhen Cao, Song Huang, Jennifer Tickner, Nan Li, Heng Qiu, Xi Chen, Chao Wang, Kai Chen, Youqiang Sun, Shiwu Dong, Jiake Xu
Osteoclasts are highly differentiated multinucleated giant cells that play fundamental roles in bone resorption and in the pathogenesis of osteolytic conditions, such as osteoporosis and cancer-induced bone loss. Achyranthes bidentata polysaccharide (ABP) is a hydrophilic compound with anti-oxidation and anti-aging characteristics. The impact of ABP on RANKL-induced osteoclast formation and bone resorption has not been assessed, hence in this study we investigated the effect of ABP on osteoclast formation and resorption in murine bone marrow derived osteoclasts...
January 18, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29344777/giant-cell-arteritis-practical-pearls-and-updates
#2
REVIEW
Swati Pradeep, Jonathan H Smith
PURPOSE OF REVIEW: The purpose of this review is to summarize recent updates and distill practical points from the literature which can be applied to the care of patients with suspected and confirmed giant cell arteritis (GCA). RECENT FINDINGS: Contemporary thinking implicates a fundamental failure of T regulatory cell function in GCA pathophysiology, representing opportunity for novel therapeutic avenues. Tocilizumab has become the first Food and Drug Administration-approved treatment for GCA following demonstration of efficacy and safety in a phase 3 clinical trial...
January 17, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29344480/primary-conjunctival-tuberculosis-presenting-as-dry-eye-a-rare-case-report-and-review-of-the-literature
#3
Rupinder Kaur Brar, Ashok Singh, Archana Hemant Deshpande, Chitrawati Bal Gargade, Sujit Das
Primary conjunctival tuberculosis is very rare in the developed countries. In an endemic country like India, it should be considered in the differential diagnosis of any unusual conjunctival lesion with unilaterality, chronicity, and nonresolution of symptoms after steroid use. We present the case of a 52-year-old female who presented with unilateral itching and blurring of vision for 20 days. There were irregular nodular elevated areas with shrinkage of the lower palpebral conjunctiva. A biopsy of the lesion revealed necrotizing epithelioid cell granulomas along with Langhans type of giant cells...
November 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29344073/bilateral-non-arteritic-anterior-ischaemic-optic-neuropathy-as-the-presentation-of-systemic-amyloidosis
#4
M Z Kanaan, A R Lorenzi, N Thampy, R Pandit, Margaret Dayan
A 75-year-old hypertensive female with stable idiopathic intermediate uveitis presented with bilateral sequential optic neuropathy with optic disc swelling. The optic neuropathy in the first affected eye (right) was thought to be due to non-arteritic anterior ischaemic optic neuropathy (NAION). Asymptomatic left optic disc swelling was found at routine review 2 months later, and a diagnosis of giant cell arteritis (GCA) was sought. Temporal artery duplex ultrasound showed the "halo sign," but a subsequent temporal artery biopsy showed light-chain (AL) amyloidosis with no signs of giant cell arteritis...
December 2017: Neuro-ophthalmology
https://www.readbyqxmd.com/read/29343075/tocilizumab-in-giant-cell-arteritis-a-real-life-retrospective-study
#5
Gianfranco Vitiello, Carolina Orsi Battaglini, Giulia Carli, Anna Radice, Andrea Matucci, Alessandra Vultaggio, Catia Olianti, Paola Parronchi, Enrico Maggi, Daniele Cammelli
This study aims to evaluate (1) the efficacy and safety of tocilizumab (TCZ) as a steroid-sparing agent in patients with giant cell arteritis (GCA) and (2) the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in the follow-up and to detect disease activity. We retrospectively evaluated 12 patients with GCA treated with TCZ (8 mg/kg/mo). Pre- and posttherapy data about clinical signs and symptoms, laboratory results, FDG-PET imaging study, and the mean glucocorticoid (GC) dose were used to assess disease activity...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29339850/giant-cell-tumour-of-tendon-sheath-and-synovial-membrane-a-review-of-26-cases
#6
Kumar Shashi Kant, Ajoy Kumar Manav, Rakesh Kumar, Abhinav, Vishvendra Kumar Sinha, Akshat Sharma
Aim: Aim of our study is to highlight the incidence and benign nature of Giant cell tumour of tendon sheath and need for complete removal, thus minimizing the chances of recurrence. Material and methods: A total of 26 cases of Giant cell tumour of tendon sheath operated in the department of Orthopaedics, Patna Medical College & Hospital, Patna from 2003 to 2010 were included in this study. The surgery was performed after clinical evaluation of the lesion and Fine Needle Aspiration Cytology (FNAC)...
November 2017: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29339027/a-comparative-study-of-osteopontin-and-mmp-2-protein-expression-in-peripheral-and-central-giant-cell-granuloma-of-the-jaws
#7
Nooshin Mohtasham, Nasrollah Saghravanian, Bahareh Fatemi, Mehdi Vahedi, Monavar Afzal-Aghaee, Hamideh Kadeh
INTRODUCTION: Oral peripheral and central giant cell granulomas are lesions with little-known etiology and pathogenesis. OBJECTIVE: The aim of this study was to compare matrix metalloproteinases-2 and osteopontin protein expression in the multinucleated giant cells and mononuclear cells of the peripheral and central giant cell granuloma lesions. METHODS: In this retrospective study, the presence of matrix metalloproteinases-2 and osteopontin in 37 cases of central giant cell granuloma and 37 cases of peripheral giant cell granuloma paraffin blocks were assessed by streptavidin-biotin immunohistochemistry...
December 27, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/29337441/-allergology-and-clinical-immunology
#8
Yann Coattrenec, Thomas Harr, Carlo Chizzolini, Peter Jandus
Hereditary angioedema (HA) is a disabling and potentially fatal condition. The management of HA includes treatment of acute attacks, short-term prophylaxis to prevent an attack, and long-term prophylaxis to minimize the frequency and severity of recurrent attacks. In this article, we will present new therapeutic alternatives for long term prophylaxis. Glucocorticoids (GC) usage leads to a number of severe side-effects. In giant cell arteritis, the use of tocilizumab in conjunction with low doses of GC reduces the number of relapses...
January 10, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29337248/immunohistochemical-characterization-of-epidermal-dendritic-like-cells-in-giant-mudskipper-periophthalmodon-schlosseri
#9
E R Lauriano, C Faggio, G Capillo, N Spanò, M Kuciel, M Aragona, S Pergolizzi
Giant Mudskipper, Periophthalmodon schlosseri (Pallas, 1770), is euryhaline, amphibious, and air-breathing fish. These fishes live in close association to mangrove forests and often spend over 90% of time out of water, in adjacent mudflats. They have developed morphological and physiological adaptations to satisfy their unique lifestyles. The skin is the primary interface between the body and the environment, and has a central role in host defence. The initiation of immune responses to antigens in the vertebrate skin has often been attributed to epidermal Langerhans'cells (LC) that are dendritic cells (DC), antigen-presenting cells (APC) which reside in the epidermis...
January 11, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29336800/oral-granular-cell-tumor-mimicking-a-giant-sialolith-in-a-child
#10
Marco Berlucchi
No abstract text is available yet for this article.
January 11, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29334779/extra-articular-tenosynovial-giant-cell-tumor-of-diffuse-type-in-the-temporal-area-with-brain-parenchymal-invasion-a-case-report
#11
Seung-Myoung Son, Young Seok Park, Chi-Hoon Choi, Ho-Chang Lee, Ok-Jun Lee, Chang Gok Woo
Tenosynovial giant cell tumor of diffuse type is a locally aggressive neoplasm that most commonly arises in the lower extremities. Herein, we report for the first time a case of an extra-articular tenosynovial giant cell tumor of diffuse type in the temporal region with brain parenchymal invasion. Imaging studies revealed an intracranial expansile mass in the temporal bone without involvement of the temporomandibular joint. The unusual location of the tumor without involvement of the joint and the presence of brain parenchymal invasion made this case challenging to diagnose...
January 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29334092/synthetic-cells-produce-a-quorum-sensing-chemical-signal-perceived-by-pseudomonas-aeruginosa
#12
Giordano Rampioni, Francesca D'Angelo, Marco Messina, Alessandro Zennaro, Yutetsu Kuruma, Daniela Tofani, Livia Leoni, Pasquale Stano
Recent developments in bottom-up synthetic biology (e.g., lipid vesicle technology integrated with cell-free protein expression systems) allow the generation of semi-synthetic minimal cells (in short, synthetic cells, SCs) endowed with some distinctive capacities of natural cells. In particular, such approaches provide technological tools and conceptual frameworks for the design and engineering of programmable SCs capable of communicating with natural cells by exchanging chemical signals. Here we describe the generation of giant vesicle-based SCs which, via gene expression, synthesize in their aqueous lumen an enzyme that in turn produces a chemical signal...
January 15, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29333854/cucurbit-8-uril-based-giant-supramolecular-vesicles-highly-stable-versatile-carriers-for-photoresponsive-and-targeted-drug-delivery
#13
Cuihua Hu, Ningning Ma, Fei Li, Yu Fang, Yao Liu, Linlu Zhao, Shanpeng Qiao, Xiumei Li, Xiaojia Jiang, Tiezhu Li, Fangzhong Shen, Yibing Huang, Quan Luo, Junqiu Liu
Highly stable giant supramolecular vesicles were constructed by hierarchical self-assembly of cucurbit[8]uril (CB[8])-based supra-amphiphiles for photoresponsive and targeted intracellular drug delivery. These smart vesicles can encapsulate the model drugs with high loading efficiencies, and then release them by manipulating photoswitchable CB[8] heteroternary complexation to regulate the formation and dissociation of supra-amphiphiles that cause dramatic morphological changes of the assemblies to achieve remote optically-controlled drug delivery...
January 15, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29333009/peripheral-and-central-giant-cell-lesions-in-children-institutional-experience-at-subharti-dental-college-and-hospital
#14
Preetika Chandna, Nikhil Srivastava, Vishal Bansal, Vijay Wadhwan, Prajesh Dubey
Introduction: Giant cell lesions (GCG) are a group of varied lesions that contain a multitude of multinucleated, osteoclast like giant cells within connective tissue stroma. These include giant cell granulomas which may be central (CGCG), if they lie within the jaw bone, or, peripheral (PGCG) if they lie within the soft tissue. Giant cell granulomas comprised 9.29% of all oral lesions. This case series comprises of 5 giant cell lesions in children between the ages of 4 to 12 years. Materials and Methods: A retrospective analysis was conducted of all patients who were diagnosed with giant cell lesions and treated over a period of 10 years (from August 2004 to August 2014) at Subharti Dental College and Hospital, Meerut, India...
October 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29332573/torsades-de-pointes-in-patients-with-polymyalgia-rheumatica
#15
Pietro Enea Lazzerini, Iacopo Bertolozzi, Maurizio Acampa, Rosella Fulceri, Franco Laghi-Pasini, Pier Leopoldo Capecchi
Polymyalgia rheumatica (PMR) represents the most common inflammatory rheumatic disease of the elderly. It is characterized by synovitis of proximal joints and extra-articular synovial structures, along with chronic high-grade systemic inflammation. PMR is closely related to giant cell arteritis (GCA), a large-vessel vasculitis that involves the major branches of the aorta, particularly the extracranial branches of carotid artery including temporal arteries. It is currently believed that PMR and GCA may represent different manifestations of the same disease process...
January 10, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29332246/an-historical-perspective-of-the-discovery-of-titin-filaments-part-2
#16
REVIEW
Cristobal G Dos Remedios
In 2017, a Special Issue of Biophysical Reviews was devoted to "Titin and Its Binding Partners. The issue contained a review: "An historical perspective of the discovery of titin filaments" by dos Remedios and Gilmour that was intended to be a history of the discovery of the giant protein titin, previously named connectin. The review took readers back to the earliest discovery of the so-called third filament component of skeletal and cardiac muscle sarcomeres and ended in 1969. Recently, my colleague Shin'ichi Ishiwata gently reminded me of two papers published in 1990 and 1993 that were unwittingly omitted from the original historical perspective...
January 13, 2018: Biophysical Reviews
https://www.readbyqxmd.com/read/29332062/cytologic-features-of-malignant-melanoma-with-osteoclast-like-giant-cells
#17
José A Jiménez-Heffernan, Magdalena Adrados, Patricia Muñoz-Hernández, Paloma Fernández-Rico, Ana I Ballesteros-García, Javier Fraga
BACKGROUND: Malignant melanoma showing numerous osteoclast-like giant cells (OGCs) is an uncommon morphologic phenomenon, rarely mentioned in the cytologic literature. The few reported cases seem to have an aggressive clinical behavior. Although most findings support monocyte/macrophage differentiation, the exact nature of OGCs is not clear. CASE: A 57-year-old woman presented with an inguinal lymphadenopathy. Sixteen years before, cutaneous malignant melanoma of the lower limb had been excised...
January 13, 2018: Acta Cytologica
https://www.readbyqxmd.com/read/29326878/ten-year-long-enzyme-replacement-therapy-shows-a-poor-effect-in-alleviating-giant-leg-ulcers-in-a-male-with-fabry-disease
#18
Jun Okada, Mohammad Arif Hossain, Chen Wu, Takashi Miyajima, Hiroko Yanagisawa, Keiko Akiyama, Yoshikatsu Eto
Fabry disease is an X-linked lysosomal storage disorder caused by a deficiency of α-galactosidase A (α-gal A), leading to the progressive accumulation of glycosphingolipids. Classical hemizygous males usually present symptoms, including pain and paresthesia in the extremities, angiokeratoma, hypo- or anhidrosis, abdominal pain, cornea verticillata, early stroke, tinnitus, and/or hearing loss, during early childhood or adolescence. Moreover, proteinuria, renal impairment, and cardiac hypertrophy can appear with age...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29326526/localized-gingival-overgrowths-a-report-of-six-cases
#19
Sohini Banerjee, T K Pal
Localized gingival overgrowths are commonly encountered in our day-to-day clinical practice and often present a diagnostic dilemma to the clinicians. These lesions vary depending on the location, site, extent, histology, and/or etiopathology. Although most of the localized gingival enlargements represent the reactive lesion to plaque accumulation, the differential diagnosis ranges from peripheral fibroma to pyogenic granuloma to peripheral fibroma with ossification and/or calcification, peripheral giant cell granuloma, etc...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326370/a-rare-case-of-giant-cell-tumour-gct-of-bone-with-lung-metastases
#20
Dheerendra Kumar Sachan, Nupur Bansal, Surabhi Gupta, Sanjeev Kumar
A case of 16-year-old girl with giant cell tumour of right fibula is presented to us with bilateral lung metastases. In view of widespread bilateral lung metastatic lesions, the patient was given multimodality treatment. Chemotherapy followed by radiotherapy to the local site as well as lung bath has been given and has shown good response.
January 11, 2018: BMJ Case Reports
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