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Jorge Kizer

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https://www.readbyqxmd.com/read/29782392/collagen-biomarkers-predict-new-onset-of-hypertension-in-normotensive-participants-the-multi-ethnic-study-of-atherosclerosis
#1
Daniel A Duprez, Myron D Gross, Joachim H Ix, Jorge R Kizer, Russell P Tracy, Steven Shea, David R Jacobs
OBJECTIVE: Vascular remodeling associated with increased extracellular matrix (ECM) may precede hypertension. Procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) reflect collagen turnover and are important in ECM remodeling. PIIINP and ICTP are increased in cardiovascular diseases (CVD). We hypothesized that PIIINP and ICTP among normotensives predict incident hypertension. METHODS: We included 1252 Multi-Ethnic Study of Atherosclerosis participants with mean age 58...
May 17, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29659743/association-of-biomarker-and-physiologic-indices-with-mortality-in-older-adults-cardiovascular-health-study
#2
Jason L Sanders, Alice M Arnold, Robert M Boudreau, Calvin H Hirsch, Jorge R Kizer, Robert C Kaplan, Anne R Cappola, Mary Cushman, Mini E Jacob, Stephen B Kritchevsky, Anne B Newman
Background: A goal of gerontology is discovering aging phenotypes that reflect biological aging distinct from disease pathogenesis. Biomarkers strongly and independently associated with mortality and which statistically attenuate chronologic age could be used to define such a phenotype. We determined the association of a Biomarker Index (BI) with mortality and compared it to a validated Physiologic Index (PI) in older adults. Methods: The indices were constructed in the Cardiovascular Health Study, mean (SD) age 74...
April 12, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29578932/carotid-artery-stiffness-and-cognitive-decline-among-women-with-or-at-risk-for-hiv-infection
#3
Daniel M Huck, David B Hanna, Leah H Rubin, Pauline Maki, Victor Valcour, Gayle Springer, Xiaonan Xue, Jason Lazar, Howard N Hodis, Kathryn Anastos, Robert C Kaplan, Jorge R Kizer
BACKGROUND: Vascular stiffness is associated with aging and cognitive impairment in older populations without HIV. HIV has been linked to increased vascular stiffness. We examined whether vascular stiffness relates to cognitive decline at younger ages in women with or at risk for HIV. METHODS: We evaluated the association of carotid artery stiffness with decline in neuropsychological test performance among participants in the Women's Interagency HIV Study, and assessed whether HIV modified the association...
March 23, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29508121/assessment-of-atherosclerotic-plaque-activity-in-patients-with-sleep-apnea-using-hybrid-positron-emission-tomography-magnetic-resonance-imaging-pet-mri-a-feasibility-study
#4
Vaishnavi Kundel, Maria Giovanna Trivieri, Nicolas A Karakatsanis, Phillip M Robson, Venkatesh Mani, Jorge R Kizer, Robert Kaplan, Zahi Fayad, Neomi Shah
PURPOSE: Evidence suggests that the inflammatory state of an atherosclerotic plaque is important in predicting future risk of plaque rupture. This study aims to investigate the feasibility of measuring plaque inflammation in patients with obstructive sleep apnea (OSA) utilizing advanced vascular imaging - hybrid positron-emission tomography/magnetic resonance imaging (PET/MRI) with fluorodeoxyglucose (FDG) tracer-before and after continuous positive airway pressure (CPAP). METHODS: Patients with newly diagnosed moderate to severe OSA underwent baseline PET/MRI for assessment of vascular inflammation of the carotid arteries and thoracic aorta prior to initiation of CPAP...
March 5, 2018: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29475876/predictive-value-of-collagen-biomarkers-for-heart-failure-with-and-without-preserved-ejection-fraction-mesa-multi-ethnic-study-of-atherosclerosis
#5
Daniel A Duprez, Myron D Gross, Jorge R Kizer, Joachim H Ix, William G Hundley, David R Jacobs
BACKGROUND: Collagen biomarkers may correlate with incident heart failure (HF) and its subtypes. We hypothesized that circulating procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) predict incident HF. METHODS AND RESULTS: We used a stratified sampling design in a multiethnic sample of 3187 subjects, initially aged 45 to 84 years and free of cardiovascular disease. We assayed baseline serum PIIINP and ICTP concentrations using radioimmunoassay...
February 23, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29447785/association-of-lipoprotein-associated-phospholipase-a-2-and-risk-of-incident-atrial-fibrillation-findings-from-3-cohorts
#6
Parveen K Garg, Traci M Bartz, Faye L Norby, Neal W Jorgensen, Robyn L McClelland, Christie M Ballantyne, Lin Y Chen, John S Gottdiener, Philip Greenland, Ron Hoogeveen, Nancy S Jenny, Jorge R Kizer, Robert S Rosenson, Elsayed Z Soliman, Mary Cushman, Alvaro Alonso, Susan R Heckbert
BACKGROUND: Multiple prospective studies have established an association between inflammation and higher risk of atrial fibrillation (AF), but the association between lipoprotein-associated phospholipase A2 (Lp-PLA2 ) mass and activity and incident AF has not been extensively evaluated. METHODS: Using data from 10,794 Atherosclerosis Risk In Communities (ARIC) study participants aged 53-75 years, 5,181 Cardiovascular Health Study (CHS) participants aged 65 to 100 years, and 5,425 Multi-Ethnic Study of Atherosclerosis (MESA) participants aged 45-84 years, we investigated the association between baseline Lp-PLA2 levels and the risk of developing AF...
March 2018: American Heart Journal
https://www.readbyqxmd.com/read/29431855/metabolic-clusters-and-outcomes-in-older-adults-the-cardiovascular-health-study
#7
Kenneth J Mukamal, David S Siscovick, Ian H de Boer, Joachim H Ix, Jorge R Kizer, Luc Djoussé, Annette L Fitzpatrick, Russell P Tracy, Edward J Boyko, Steven E Kahn, Alice M Arnold
BACKGROUND/OBJECTIVES: Few studies have the requisite phenotypic information to define metabolic patterns that may inform our understanding of the pathophysiology and consequences of diabetes in older adults. We sought to characterize clusters of older adults on the basis of shared metabolic features. DESIGN: Population-based prospective cohort study. SETTING: Four U.S. Cardiovascular Health Study field centers. PARTICIPANTS: Individuals aged 65 and older taking no glucose-lowering agents (N = 2,231)...
February 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29322198/association-of-cardiovascular-biomarkers-with-incident-heart-failure-with-preserved-and-reduced-ejection-fraction
#8
Rudolf A de Boer, Matthew Nayor, Christopher R deFilippi, Danielle Enserro, Vijeta Bhambhani, Jorge R Kizer, Michael J Blaha, Frank P Brouwers, Mary Cushman, Joao A C Lima, Hossein Bahrami, Pim van der Harst, Thomas J Wang, Ron T Gansevoort, Caroline S Fox, Hanna K Gaggin, Willem J Kop, Kiang Liu, Ramachandran S Vasan, Bruce M Psaty, Douglas S Lee, Hans L Hillege, Traci M Bartz, Emelia J Benjamin, Cheeling Chan, Matthew Allison, Julius M Gardin, James L Januzzi, Sanjiv J Shah, Daniel Levy, David M Herrington, Martin G Larson, Wiek H van Gilst, John S Gottdiener, Alain G Bertoni, Jennifer E Ho
Importance: Nearly half of all patients with heart failure have preserved ejection fraction (HFpEF) as opposed to reduced ejection fraction (HFrEF), yet associations of biomarkers with future heart failure subtype are incompletely understood. Objective: To evaluate the associations of 12 cardiovascular biomarkers with incident HFpEF vs HFrEF among adults from the general population. Design, Setting, and Participants: This study included 4 longitudinal community-based cohorts: the Cardiovascular Health Study (1989-1990; 1992-1993 for supplemental African-American cohort), the Framingham Heart Study (1995-1998), the Multi-Ethnic Study of Atherosclerosis (2000-2002), and the Prevention of Renal and Vascular End-stage Disease study (1997-1998)...
March 1, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29226491/predictors-and-outcomes-of-heart-failure-with-mid-range-ejection-fraction
#9
Vijeta Bhambhani, Jorge R Kizer, Joao A C Lima, Pim van der Harst, Hossein Bahrami, Matthew Nayor, Christopher R de Filippi, Danielle Enserro, Michael J Blaha, Mary Cushman, Thomas J Wang, Ron T Gansevoort, Caroline S Fox, Hanna K Gaggin, Willem J Kop, Kiang Liu, Ramachandran S Vasan, Bruce M Psaty, Douglas S Lee, Frank P Brouwers, Hans L Hillege, Traci M Bartz, Emelia J Benjamin, Cheeling Chan, Matthew Allison, Julius M Gardin, James L Januzzi, Daniel Levy, David M Herrington, Wiek H van Gilst, Alain G Bertoni, Martin G Larson, Rudolf A de Boer, John S Gottdiener, Sanjiv J Shah, Jennifer E Ho
AIMS: While heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF) are well described, determinants and outcomes of heart failure with mid-range ejection fraction (HFmrEF) remain unclear. We sought to examine clinical and biochemical predictors of incident HFmrEF in the community. METHODS AND RESULTS: We pooled data from four community-based longitudinal cohorts, with ascertainment of new heart failure (HF) classified into HFmrEF [ejection fraction (EF) 41-49%], HFpEF (EF ≥50%), and HFrEF (EF ≤40%)...
April 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29050621/association-of-chronic-kidney-disease-with-in-hospital-outcomes-of-transcatheter-aortic-valve-replacement
#10
Tanush Gupta, Kashish Goel, Dhaval Kolte, Sahil Khera, Pedro A Villablanca, Wilbert S Aronow, Anna E Bortnick, David P Slovut, Cynthia C Taub, Jorge R Kizer, Robert T Pyo, J Dawn Abbott, Gregg C Fonarow, Charanjit S Rihal, Mario J Garcia, Deepak L Bhatt
OBJECTIVES: This study sought to determine the association of chronic kidney disease (CKD) with in-hospital outcomes of transcatheter aortic valve replacement (TAVR). BACKGROUND: CKD is a known independent risk factor for worse outcomes after surgical aortic valve replacement (SAVR). However, data on outcomes of patients with CKD undergoing TAVR are limited, especially in those on chronic dialysis. METHODS: The authors used data from the 2012 to 2014 National Inpatient Sample database to identify all patients ≥18 years of age who underwent TAVR...
October 23, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28904058/evaluation-of-lipoprotein-a-electrophoretic-and-immunoassay-methods-in-discriminating-risk-of-calcific-aortic-valve-disease-and-incident-coronary-heart-disease-the-multi-ethnic-study-of-atherosclerosis
#11
RANDOMIZED CONTROLLED TRIAL
Jing Cao, Brian T Steffen, Weihua Guan, Matthew Budoff, Erin D Michos, Jorge R Kizer, Wendy S Post, Michael Y Tsai
BACKGROUND: A number of lipoprotein(a) [Lp(a)] analytical techniques are available that quantify distinct particle components, yet their clinical efficacy has not been comprehensively evaluated. This study determined whether Lp(a) mass [Lp(a)-M], Lp(a) cholesterol content [Lp(a)-C], and particle concentration [Lp(a)-P] differentially discriminated risk of calcific aortic valve disease (CAVD) or incident coronary heart disease (CHD) among 4679 participants of the Multi-Ethnic Study of Atherosclerosis (MESA)...
November 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28899988/impact-of-incident-heart-failure-on-body-composition-over-time-in-the-health-aging-and-body-composition-study-population
#12
MULTICENTER STUDY
Daniel E Forman, Adam J Santanasto, Robert Boudreau, Tamara Harris, Alka M Kanaya, Suzanne Satterfield, Eleanor M Simonsick, Javed Butler, Jorge R Kizer, Anne B Newman
BACKGROUND: Prevalence of heart failure (HF) increases significantly with age, coinciding with age-related changes in body composition that are common and consequential. Still, body composition is rarely factored in routine HF care. METHODS AND RESULTS: The Health, Aging, and Body Composition study is a prospective cohort study of nondisabled adults. Using yearly dual-energy x-ray absorptiometry, body composition was assessed in the Health, Aging, and Body Composition study over 6 years, comparing those who developed incident HF versus those who did not...
September 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28733431/addition-of-24-hour-heart-rate-variability-parameters-to-the-cardiovascular-health-study-stroke-risk-score-and-prediction-of-incident-stroke-the-cardiovascular-health-study
#13
MULTICENTER STUDY
Rohan K Bodapati, Jorge R Kizer, Willem J Kop, Hooman Kamel, Phyllis K Stein
BACKGROUND: Heart rate variability (HRV) characterizes cardiac autonomic functioning. The association of HRV with stroke is uncertain. We examined whether 24-hour HRV added predictive value to the Cardiovascular Health Study clinical stroke risk score (CHS-SCORE), previously developed at the baseline examination. METHODS AND RESULTS: N=884 stroke-free CHS participants (age 75.3±4.6), with 24-hour Holters adequate for HRV analysis at the 1994-1995 examination, had 68 strokes over ≤8 year follow-up (median 7...
July 21, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28674618/higher-number-of-live-births-is-associated-with-left-ventricular-diastolic-dysfunction-and-adverse-cardiac-remodelling-among-us-hispanic-latina-women-results-from-the-echocardiographic-study-of-latinos
#14
Shivani R Aggarwal, David M Herrington, Catherine J Vladutiu, Jill C Newman, Katrina Swett, Franklyn Gonzalez, Jorge R Kizer, Michelle A Kominiarek, Karen M Tabb, Linda C Gallo, Gregory A Talavera, Barry E Hurwitz, Carlos J Rodriguez
INTRODUCTION: Female sex is a risk factor for heart failure with preserved ejection fraction (HFpEF). Previous literature suggests that some diastolic dysfunction (DD) develops during pregnancy and may persist postdelivery. Our objective was to examine the relationship between parity and cardiac structure and function in a population-based cohort. METHODS: Participants included 1172 Hispanic/Latina women, aged ≥45 years, enrolled in the Echocardiographic Study of Latinos from four US communities (Bronx, Miami, San Diego and Chicago)...
2017: Open Heart
https://www.readbyqxmd.com/read/28583687/relation-of-serum-vitamin-d-to-risk-of-mitral-annular-and-aortic-valve-calcium-from-the-multi-ethnic-study-of-atherosclerosis
#15
MULTICENTER STUDY
Martin Tibuakuu, Di Zhao, Ian H de Boer, Eliseo Guallar, Anna E Bortnick, Pamela L Lutsey, Matthew J Budoff, Jorge R Kizer, Bryan R Kestenbaum, Erin D Michos
Serum 25-hydroxyvitamin D [25(OH)D] concentration has been identified as a possible modifiable risk factor for cardiovascular disease (CVD). We hypothesized that serum 25(OH)D concentration would be associated with calcifications of the left-sided heart valves, which are markers of CVD risk. Aortic valve calcium (AVC) and mitral annular calcium (MAC) were quantified from cardiac computed tomography scans performed on 5,530 Multi-Ethnic Study of Atherosclerosis participants at the baseline examination (2000 to 2002) and at a follow-up visit at either Examination 2 (2002 to 2004) or Examination 3 (2004 to 2005)...
August 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28560501/relationship-of-bone-mineral-density-with-valvular-and-annular-calcification-in-community-dwelling-older-people-the-cardiovascular-health-study
#16
MULTICENTER STUDY
Daniele Massera, Shuo Xu, Traci M Bartz, Anna E Bortnick, Joachim H Ix, Michel Chonchol, David S Owens, Eddy Barasch, Julius M Gardin, John S Gottdiener, John R Robbins, David S Siscovick, Jorge R Kizer
Associations between bone mineral density and aortic valvular, aortic annular, and mitral annular calcification were investigated in a cross-sectional analysis of a population-based cohort of 1497 older adults. Although there was no association between continuous bone mineral density and outcomes, a significant association between osteoporosis and aortic valvular calcification in men was found. INTRODUCTION: The process of cardiac calcification bears a resemblance to skeletal bone metabolism and its regulation...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28515098/collagen-turnover-markers-in-relation-to-future-cardiovascular-and-noncardiovascular-disease-the-multi-ethnic-study-of-atherosclerosis
#17
Daniel A Duprez, Myron D Gross, Otto A Sanchez, Jorge R Kizer, Joachim H Ix, Joao Lima, Russell P Tracy, David R Jacobs
BACKGROUND: Sustained remodeling of extracellular matrix can compromise organs and tissues. Procollagen type III N-terminal propeptide (PIIINP) and collagen type I carboxy-terminal telopeptide (ICTP) reflect collagen synthesis and degradation. We studied their predictive value for future death and disease. METHODS: A total of 3068 men and women in the Multi-Ethnic Study of Atherosclerosis who were free of cardiovascular disease (CVD) and in generally good health had a baseline blood sample taken for ICTP and PIIINP...
July 2017: Clinical Chemistry
https://www.readbyqxmd.com/read/28438309/association-of-albuminuria-with-cardiac-dysfunction-in-us-hispanics-latinos
#18
MULTICENTER STUDY
David B Hanna, Shuo Xu, Michal L Melamed, Franklyn Gonzalez, Matthew A Allison, Martin S Bilsker, Barry E Hurwitz, Mayank M Kansal, Neil Schneiderman, Sanjiv J Shah, Robert C Kaplan, Carlos J Rodriguez, Jorge R Kizer
Higher urine albumin-to-creatinine ratio (UACR) has been associated with cardiac dysfunction in the general population. We assessed the association of UACR with cardiac structure and function in the Echocardiographic Study of Latinos (Echo-SOL), an ancillary study of the Hispanic Community Health Study/Study of Latinos across 4 US sites. Echo-SOL participants underwent standard 2-dimensional echocardiography, including speckle-tracking strain analysis. UACR was categorized as normal and high-normal (based on the midpoint of values below microalbuminuria), microalbuminuria (≥17 mg/g for men; ≥25 mg/g for women), and macroalbuminuria (≥250 mg/g; ≥355 mg/g)...
June 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28379451/detection-of-genetic-loci-associated-with-plasma-fetuin-a-a-meta-analysis-of-genome-wide-association-studies-from-the-charge-consortium
#19
Majken K Jensen, Richard A Jensen, Kenneth J Mukamal, Xiuqing Guo, Jie Yao, Qi Sun, Marilyn Cornelis, Yongmei Liu, Ming-Huei Chen, Jorge R Kizer, Luc Djoussé, David S Siscovick, Bruce M Psaty, Joseph M Zmuda, Jerome I Rotter, Melissa Garcia, Tamara Harris, Ida Chen, Mark O Goodarzi, Michael A Nalls, Margaux Keller, Alice M Arnold, Anne B Newman, Ron C Hoogeveen, Kathryn M Rexrode, Eric B Rimm, Frank B Hu, Vasan S Ramachandran, Ronit Katz, James S Pankow, Joachim H Ix
Plasma fetuin-A is associated with type 2 diabetes, and AHSG, the gene encoding fetuin-A, has been identified as a susceptibility locus for diabetes and metabolic syndrome. Thus far, unbiased investigations of the genetic determinants of plasma fetuin-A concentrations have not been conducted. We searched for single nucleotide polymorphisms (SNPs) related to fetuin-A concentrations by a genome-wide association study in six population-based studies. We examined the association of fetuin-A levels with ∼ 2...
June 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28328784/direct-xa-inhibitors-in-addition-to-antiplatelet-therapy-in-acute-coronary-syndrome-meta-analysis-of-randomized-trials
#20
Pedro A Villablanca, David Holmes, Divyanshu Mohananey, David F Briceno, Ivan J Núñez Gil, Faraj Kargoli, Tanush Gupta, Jorge R Kizer, Anna E Bortnick, Jose Wiley, Mark A Menegus, Robert Pyo, Mario García, Harish Ramakrishna, Farouk Mookadam
OBJECTIVE: We carried out a meta-analysis summarizing the efficacy and safety of direct factor Xa inhibitor (DXI) in patients receiving guideline-based antiplatelet therapy (GBAT) after an acute coronary syndrome. BACKGROUND: Randomized-controlled trials have shown that the addition of a DXI to GBAT after acute coronary syndrome can reduce ischemic events, the trade-off being an increase in major bleeding complications. METHODS: PubMed, Central, Embase, The Cochrane Register, Google Scholar databases, and the scientific session abstracts were searched for eligible randomized trials from 1 January 1990 through 31 December 2016...
August 2017: Coronary Artery Disease
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