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Jorge Kizer

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https://www.readbyqxmd.com/read/27835618/increased-glucose-transporter-1-expression-on-intermediate-monocytes-from-hiv-infected-women-with-subclinical-cardiovascular-disease
#1
Tiffany R Butterfield, David B Hanna, Robert C Kaplan, Jorge R Kizer, Helen G Durkin, Mary A Young, Marek J Nowicki, Phyllis C Tien, Elizabeth T Golub, Michelle A Floris-Moore, Kehmia Titanji, Margaret A Fischl, Sonya L Heath, Jefferey Martinson, Suzanne M Crowe, Clovis S Palmer, Alan L Landay, Joshua J Anzinger
OBJECTIVE: People living with HIV (PLWH) have chronic immune activation and increased cardiovascular disease (CVD) risk. Activation of monocytes and T lymphocytes causes up-regulation of glucose transporter-1 (GLUT1) for efficient function. PLWH have an increased percentage of GLUT1-expressing monocytes and T lymphocytes, but it is unclear if these cells are associated with CVD. We evaluated expression of GLUT1 and CD38 on monocyte and T lymphocyte populations from HIV-infected women with subclinical CVD...
November 9, 2016: AIDS
https://www.readbyqxmd.com/read/27820656/insulinlike-growth-factor-binding-protein-1-and-ghrelin-predict-health-outcomes-among-older-adults-chs-cohort
#2
Robert C Kaplan, Garrett Strizich, Chino Aneke-Nash, Clara Dominguez-Islas, Petra Bůžková, Howard Strickler, Thomas Rohan, Michael Pollak, Lewis Kuller, Jorge R Kizer, Anne Cappola, Christopher I Li, Bruce M Psaty, Anne Newman
CONTEXT: Multiple diseases may explain the association of the growth hormone / insulinlike growth factor-I (GH/IGF-I) axis with longevity. OBJECTIVE: To relate circulating GH/IGF-I system protein levels with major health events. DESIGN: Cohort study Setting: Four US communities Participants: Adults (n=2268) 65 years and older free of diabetes and cardiovascular disease. MEASUREMENTS: We assessed insulinlike growth factor binding protein-1 (IGFBP-1) and ghrelin in fasting and 2-hour oral glucose tolerance test (OGTT) blood samples, as well as fasting IGF-I and IGFBP-3...
November 7, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27732332/testosterone-dihydrotestosterone-sex-hormone-binding-globulin-and-incident-diabetes-among-older-men-the-cardiovascular-health-study
#3
Katherine E Joyce, Mary L Biggs, Luc Djoussé, Joachim H Ix, Jorge R Kizer, David S Siscovick, Molly M Shores, Alvin M Matsumoto, Kenneth J Mukamal
CONTEXT: Although sex hormone binding globulin (SHBG) and testosterone (T) have been inversely associated with risk of diabetes, few studies have examined dihydrotestosterone (DHT), a more potent androgen than T, or older adults, whose glycemic pathophysiology differs from younger adults. OBJECTIVE: To determine the associations of SHBG, T, and DHT with insulin resistance and incident diabetes in older adult men. DESIGN: In a prospective cohort study, we evaluated baseline levels of SHBG, T, and DHT using liquid chromatography-tandem mass spectrometry among 852 men in the Cardiovascular Health Study free of diabetes and cardiovascular disease in 1994...
October 12, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27683756/circulating-protein-z-concentration-proz-variants-and-unexplained-cerebral-infarction-in-young-and-middle-aged-adults
#4
Lili Zhang, Alan Z Segal, Dana Leifer, Roy L Silverstein, Linda M Gerber, Richard B Devereux, Jorge R Kizer
Protein Z (PZ) is a vitamin K-dependent plasma protein that exhibits both pro- and anticoagulant properties. Both low and high PZ levels have been linked to ischaemic stroke. Although PZ-lowering gene variants have been found to be less common in ischaemic stroke, the relationship remains unclear. We investigated PZ levels and PROZ variants in a multi-ethnic case-control study of unexplained stroke in participants aged 18 to 64. Plasma PZ was measured in cases (≥2 months post-stroke) and controls. PZ polymorphisms G79A (rs3024735) and A13G (2273971) were genotyped...
September 29, 2016: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/27621184/longitudinal-assessment-of-n-terminal-pro-b-type-natriuretic-peptide-and-risk-of-diabetes-in-older-adults-the-cardiovascular-health-study
#5
Erika F Brutsaert, Mary L Biggs, Joseph A Delaney, Luc Djoussé, John S Gottdiener, Joachim H Ix, Francis Kim, Kenneth J Mukamal, David S Siscovick, Russell P Tracy, Ian H de Boer, Christopher R deFilippi, Jorge R Kizer
INTRODUCTION: Natriuretic peptides have a well-recognized role in cardiovascular homeostasis. Recently, higher levels of B-type natriuretic peptide (BNP) have also been associated with decreased risk of diabetes in middle-aged adults. Whether this association persists into older age, where the pathophysiology of diabetes changes, has not been established, nor has its intermediate pathways. METHODS: We investigated the relationship between N-terminal (NT)-proBNP and incident diabetes in 2359 older adults free of cardiovascular disease or chronic kidney disease in the Cardiovascular Health Study...
October 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27575936/lipoprotein-a-level-apolipoprotein-a-size-and-risk-of-unexplained-ischemic-stroke-in-young-and-middle-aged-adults
#6
Azadeh Beheshtian, Sanyog G Shitole, Alan Z Segal, Dana Leifer, Russell P Tracy, Daniel J Rader, Richard B Devereux, Jorge R Kizer
BACKGROUND AND AIMS: Circulating lipoprotein (a) [Lp(a)] level relates inversely to apolipoprotein (a) [apo(a)] size. Both smaller apo(a) isoforms and higher Lp(a) levels have been linked to coronary heart disease and stroke, but their independent contributions are less well defined. We examined the role of Lp(a) in younger adults with cryptogenic stroke. METHODS: Lp(a) and apo(a) isoforms were evaluated in a prospectively designed case-control study of patients with unexplained ischemic stroke and stroke-free controls, ages 18 to 64...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27466464/practice-advisory-recurrent-stroke-with-patent-foramen-ovale-update-of-practice-parameter-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology
#7
Steven R Messé, Gary Gronseth, David M Kent, Jorge R Kizer, Shunichi Homma, Lee Rosterman, Scott E Kasner
OBJECTIVE: To update the 2004 American Academy of Neurology guideline for patients with stroke and patent foramen ovale (PFO) by addressing whether (1) percutaneous closure of PFO is superior to medical therapy alone and (2) anticoagulation is superior to antiplatelet therapy for the prevention of recurrent stroke. METHODS: Systematic review of the literature and structured formulation of recommendations. CONCLUSIONS: Percutaneous PFO closure with the STARFlex device possibly does not provide a benefit in preventing stroke vs medical therapy alone (risk difference [RD] 0...
August 23, 2016: Neurology
https://www.readbyqxmd.com/read/27444412/trends-in-cardiovascular-disease-mortality-among-persons-with-hiv-in-new-york-city-2001-2012
#8
David B Hanna, Chitra Ramaswamy, Robert C Kaplan, Jorge R Kizer, Kathryn Anastos, Demetre Daskalakis, Regina Zimmerman, Sarah L Braunstein
BACKGROUND: Cardiovascular disease (CVD) has become more prominent among human immunodeficiency virus (HIV)-infected individuals. The extent to which CVD mortality rates are changing is unclear. METHODS: We analyzed surveillance data for all persons aged ≥13 years with HIV infection between 2001 and 2012 reported to the New York City HIV Surveillance Registry. We examined age-specific and age-standardized mortality rates due to major CVDs. We compared mortality time trends among persons with HIV with the general population, and examined differences among HIV-infected persons by RNA level...
October 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27416945/genome-wide-association-study-of-the-modified-stumvoll-insulin-sensitivity-index-identifies-bcl2-and-fam19a2-as-novel-insulin-sensitivity-loci
#9
Geoffrey A Walford, Stefan Gustafsson, Denis Rybin, Alena Stančáková, Han Chen, Ching-Ti Liu, Jaeyoung Hong, Richard A Jensen, Ken Rice, Andrew P Morris, Reedik Mägi, Anke Tönjes, Inga Prokopenko, Marcus E Kleber, Graciela Delgado, Günther Silbernagel, Anne U Jackson, Emil V Appel, Niels Grarup, Joshua P Lewis, May E Montasser, Claes Landenvall, Harald Staiger, Jian'an Luan, Timothy M Frayling, Michael N Weedon, Weijia Xie, Sonsoles Morcillo, María Teresa Martínez-Larrad, Mary L Biggs, Yii-Der Ida Chen, Arturo Corbaton-Anchuelo, Kristine Færch, Juan Miguel Gómez-Zumaquero, Mark O Goodarzi, Jorge R Kizer, Heikki A Koistinen, Aaron Leong, Lars Lind, Cecilia Lindgren, Fausto Machicao, Alisa K Manning, Gracia María Martín-Núñez, Gemma Rojo-Martínez, Jerome I Rotter, David S Siscovick, Joseph M Zmuda, Zhongyang Zhang, Manuel Serrano-Rios, Ulf Smith, Federico Soriguer, Torben Hansen, Torben J Jørgensen, Allan Linnenberg, Oluf Pedersen, Mark Walker, Claudia Langenberg, Robert A Scott, Nicholas J Wareham, Andreas Fritsche, Hans-Ulrich Häring, Norbert Stefan, Leif Groop, Jeff R O'Connell, Michael Boehnke, Richard N Bergman, Francis S Collins, Karen L Mohlke, Jaakko Tuomilehto, Winfried März, Peter Kovacs, Michael Stumvoll, Bruce M Psaty, Johanna Kuusisto, Markku Laakso, James B Meigs, Josée Dupuis, Erik Ingelsson, Jose C Florez
Genome-wide association studies (GWAS) have found few common variants that influence fasting measures of insulin sensitivity. We hypothesized that a GWAS of an integrated assessment of fasting and dynamic measures of insulin sensitivity would detect novel common variants. We performed a GWAS of the modified Stumvoll Insulin Sensitivity Index (ISI) within the Meta-Analyses of Glucose and Insulin-Related Traits Consortium. Discovery for genetic association was performed in 16,753 individuals, and replication was attempted for the 23 most significant novel loci in 13,354 independent individuals...
October 2016: Diabetes
https://www.readbyqxmd.com/read/27411840/association-of-inflammatory-lipid-and-mineral-markers-with-cardiac-calcification-in-older-adults
#10
Anna E Bortnick, Traci M Bartz, Joachim H Ix, Michel Chonchol, Alexander Reiner, Mary Cushman, David Owens, Eddy Barasch, David S Siscovick, John S Gottdiener, Jorge R Kizer
OBJECTIVE: Calcification of the aortic valve and adjacent structures involves inflammatory, lipid and mineral metabolism pathways. We hypothesised that circulating biomarkers reflecting these pathways are associated with cardiac calcification in older adults. METHODS: We investigated the associations of various biomarkers with valvular and annular calcification in the Cardiovascular Health Study. Of the 5888 participants, up to 3585 were eligible after exclusions for missing biomarker, covariate or echocardiographic data...
July 13, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27321945/trans-ethnic-meta-analysis-and-functional-annotation-illuminates-the%C3%A2-genetic-architecture-of-fasting-glucose-and-insulin
#11
Ching-Ti Liu, Sridharan Raghavan, Nisa Maruthur, Edmond Kato Kabagambe, Jaeyoung Hong, Maggie C Y Ng, Marie-France Hivert, Yingchang Lu, Ping An, Amy R Bentley, Anne M Drolet, Kyle J Gaulton, Xiuqing Guo, Loren L Armstrong, Marguerite R Irvin, Man Li, Leonard Lipovich, Denis V Rybin, Kent D Taylor, Charles Agyemang, Nicholette D Palmer, Brian E Cade, Wei-Min Chen, Marco Dauriz, Joseph A C Delaney, Todd L Edwards, Daniel S Evans, Michele K Evans, Leslie A Lange, Aaron Leong, Jingmin Liu, Yongmei Liu, Uma Nayak, Sanjay R Patel, Bianca C Porneala, Laura J Rasmussen-Torvik, Marieke B Snijder, Sarah C Stallings, Toshiko Tanaka, Lisa R Yanek, Wei Zhao, Diane M Becker, Lawrence F Bielak, Mary L Biggs, Erwin P Bottinger, Donald W Bowden, Guanjie Chen, Adolfo Correa, David J Couper, Dana C Crawford, Mary Cushman, John D Eicher, Myriam Fornage, Nora Franceschini, Yi-Ping Fu, Mark O Goodarzi, Omri Gottesman, Kazuo Hara, Tamara B Harris, Richard A Jensen, Andrew D Johnson, Min A Jhun, Andrew J Karter, Margaux F Keller, Abel N Kho, Jorge R Kizer, Ronald M Krauss, Carl D Langefeld, Xiaohui Li, Jingling Liang, Simin Liu, William L Lowe, Thomas H Mosley, Kari E North, Jennifer A Pacheco, Patricia A Peyser, Alan L Patrick, Kenneth M Rice, Elizabeth Selvin, Mario Sims, Jennifer A Smith, Salman M Tajuddin, Dhananjay Vaidya, Mary P Wren, Jie Yao, Xiaofeng Zhu, Julie T Ziegler, Joseph M Zmuda, Alan B Zonderman, Aeilko H Zwinderman, Adebowale Adeyemo, Eric Boerwinkle, Luigi Ferrucci, M Geoffrey Hayes, Sharon L R Kardia, Iva Miljkovic, James S Pankow, Charles N Rotimi, Michele M Sale, Lynne E Wagenknecht, Donna K Arnett, Yii-Der Ida Chen, Michael A Nalls, Michael A Province, W H Linda Kao, David S Siscovick, Bruce M Psaty, James G Wilson, Ruth J F Loos, Josée Dupuis, Stephen S Rich, Jose C Florez, Jerome I Rotter, Andrew P Morris, James B Meigs
Knowledge of the genetic basis of the type 2 diabetes (T2D)-related quantitative traits fasting glucose (FG) and insulin (FI) in African ancestry (AA) individuals has been limited. In non-diabetic subjects of AA (n = 20,209) and European ancestry (EA; n = 57,292), we performed trans-ethnic (AA+EA) fine-mapping of 54 established EA FG or FI loci with detailed functional annotation, assessed their relevance in AA individuals, and sought previously undescribed loci through trans-ethnic (AA+EA) meta-analysis. We narrowed credible sets of variants driving association signals for 22/54 EA-associated loci; 18/22 credible sets overlapped with active islet-specific enhancers or transcription factor (TF) binding sites, and 21/22 contained at least one TF motif...
July 7, 2016: American Journal of Human Genetics
https://www.readbyqxmd.com/read/27321602/effects-of-disease-burden-and-functional-adaptation-on-morbidity-and-mortality-on-older-adults
#12
Jason L Sanders, Alice M Arnold, Calvin H Hirsch, Stephen M Thielke, Dae Kim, Kenneth J Mukamal, Jorge R Kizer, Joachim H Ix, Robert C Kaplan, Stephen B Kritchevsky, Anne B Newman
OBJECTIVES: To ascertain whether older adults with extensive disease but relative vigor (adapters) shorten the period at the end of life in which they live with morbidity (compress morbidity). DESIGN: Prospective, community-based cohort study in four U.S. cities. SETTING: Cardiovascular Health Study. PARTICIPANTS: Individuals aged 65 and older. MEASUREMENTS: Participants were categorized into three groups according to extent of disease (assessed noninvasively), vigor, and frailty (expected agers (n = 3,528, extent of disease similar to vigor and frailty-reference group), adapters (n = 882, higher disease but vigorous), and prematurely frail (n = 855, lower disease but frail)) and compared according to years of able life (YAL), years of self-reported healthy life (YHL), and mortality using multivariable regression and survival analysis...
June 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27272182/trajectories-of-function-and-biomarkers-with-age-the-chs-all-stars-study
#13
Anne B Newman, Jason L Sanders, Jorge R Kizer, Robert M Boudreau, Michelle C Odden, Adina Zeki Al Hazzouri, Alice M Arnold
BACKGROUND: Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways. METHODS: We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90...
August 2016: International Journal of Epidemiology
https://www.readbyqxmd.com/read/27266854/predicting-heart-failure-with-preserved-and-reduced-ejection-fraction-the-international-collaboration-on-heart-failure-subtypes
#14
Jennifer E Ho, Danielle Enserro, Frank P Brouwers, Jorge R Kizer, Sanjiv J Shah, Bruce M Psaty, Traci M Bartz, Rajalakshmi Santhanakrishnan, Douglas S Lee, Cheeling Chan, Kiang Liu, Michael J Blaha, Hans L Hillege, Pim van der Harst, Wiek H van Gilst, Willem J Kop, Ron T Gansevoort, Ramachandran S Vasan, Julius M Gardin, Daniel Levy, John S Gottdiener, Rudolf A de Boer, Martin G Larson
BACKGROUND: Heart failure (HF) is a prevalent and deadly disease, and preventive strategies focused on at-risk individuals are needed. Current HF prediction models have not examined HF subtypes. We sought to develop and validate risk prediction models for HF with preserved and reduced ejection fraction (HFpEF, HFrEF). METHODS AND RESULTS: Of 28,820 participants from 4 community-based cohorts, 982 developed incident HFpEF and 909 HFrEF during a median follow-up of 12 years...
June 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27264232/cardiovascular-health-among-diverse-hispanics-latinos-hispanic-community-health-study-study-of-latinos-hchs-sol-results
#15
Hector M González, Wassim Tarraf, Carlos J Rodríguez, Linda C Gallo, Ralph L Sacco, Gregory A Talavera, Gerardo Heiss, Jorge R Kizer, Rosalba Hernandez, Sonia Davis, Neil Schneiderman, Martha L Daviglus, Robert C Kaplan
BACKGROUND: Seven national 2020 Strategic Impact Goals for cardiovascular health (Life's Simple 7 [LS7]) estimates for major ethnic/racial groups are available, but not for diverse Hispanics/Latinos. Herein, we describe and examine LS7 profiles of diverse Hispanic/Latino groups. METHODS: HCHS/SOL (analytic n = 15,825; ages 18-74 years) data were used to estimate LS7 metrics. LS7 metrics were operationalized as Ideal, Intermediate, or Poor and indexed as an additive score...
June 2016: American Heart Journal
https://www.readbyqxmd.com/read/27188936/measures-of-body-size-and-composition-and-risk-of-incident-atrial-fibrillation-in-older-people-the-cardiovascular-health-study
#16
Maria G Karas, Laura M Yee, Mary L Biggs, Luc Djoussé, Kenneth J Mukamal, Joachim H Ix, Susan J Zieman, David S Siscovick, John S Gottdiener, Michael A Rosenberg, Richard A Kronmal, Susan R Heckbert, Jorge R Kizer
Various anthropometric measures, including height, have been associated with atrial fibrillation (AF). This raises questions about the appropriateness of using ratio measures such as body mass index (BMI), which contains height squared in its denominator, in the evaluation of AF risk. Among older adults, the optimal anthropometric approach to risk stratification of AF remains uncertain. Anthropometric and bioelectrical impedance measures were obtained from 4,276 participants (mean age = 72.4 years) free of cardiovascular disease in the Cardiovascular Health Study...
June 1, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27012580/assessing-cardiac-metabolism-a-scientific-statement-from-the-american-heart-association
#17
Heinrich Taegtmeyer, Martin E Young, Gary D Lopaschuk, E Dale Abel, Henri Brunengraber, Victor Darley-Usmar, Christine Des Rosiers, Robert Gerszten, Jan F Glatz, Julian L Griffin, Robert J Gropler, Hermann-Georg Holzhuetter, Jorge R Kizer, E Douglas Lewandowski, Craig R Malloy, Stefan Neubauer, Linda R Peterson, Michael A Portman, Fabio A Recchia, Jennifer E Van Eyk, Thomas J Wang
In a complex system of interrelated reactions, the heart converts chemical energy to mechanical energy. Energy transfer is achieved through coordinated activation of enzymes, ion channels, and contractile elements, as well as structural and membrane proteins. The heart's needs for energy are difficult to overestimate. At a time when the cardiovascular research community is discovering a plethora of new molecular methods to assess cardiac metabolism, the methods remain scattered in the literature. The present statement on "Assessing Cardiac Metabolism" seeks to provide a collective and curated resource on methods and models used to investigate established and emerging aspects of cardiac metabolism...
May 13, 2016: Circulation Research
https://www.readbyqxmd.com/read/26910597/recent-insights-into-cardiovascular-disease-cvd-risk-among-hiv-infected-adults
#18
Robert C Kaplan, David B Hanna, Jorge R Kizer
While mortality rates related to cardiovascular disease (CVD) have decreased over time among adults with HIV, excess risk of CVD in the HIV-infected population may persist despite highly active antiretroviral therapy (HAART) treatment and aggressive CVD risk factor control. Beyond atherosclerotic CVD, recent studies suggest that HIV infection may be associated with left ventricular systolic and diastolic function, interstitial myocardial fibrosis, and increased cardiac fat infiltration. Thus, with the increasing average age of the HIV-infected population, heart failure and arrhythmic disorders may soon rival coronary artery disease as the most prevalent forms of CVD...
February 2016: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/26897639/clinical-profile-acute-care-and-middle-term-outcomes-of-cocaine-associated-st-segment-elevation-myocardial-infarction-in-an-inner-city-community
#19
MULTICENTER STUDY
Sanyog G Shitole, Noel Kayo, Vankeepuram Srinivas, Venkatesh Alapati, Charles Nordin, William Southern, Panagiota Christia, Robert T Faillace, James Scheuer, Jorge R Kizer
Although cocaine is a well-recognized risk factor for coronary disease, detailed information is lacking regarding related behavioral and clinical features of cocaine-associated ST-segment elevation myocardial infarction (STEMI), particularly in socioeconomically disadvantaged urban settings. Nor are systematic or extended follow-up data available on outcomes for cocaine-associated STEMI in the contemporary era of percutaneous coronary intervention. We leveraged a prospective STEMI registry from a large health system serving an inner-city community to characterize the clinical features, acute management, and middle-term outcomes of cocaine-related versus cocaine-unrelated STEMI...
April 15, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/26348768/adipokines-and-the-right-ventricle-the-mesa-rv-study
#20
Michael O Harhay, Jorge R Kizer, Michael H Criqui, João A C Lima, Russell Tracy, David A Bluemke, Steven M Kawut
OBJECTIVE: Obesity is associated with changes in both right (RV) and left (LV) ventricular morphology, but the biological basis of this finding is not well established. We examined whether adipokine levels were associated with RV morphology and function in a population-based multiethnic sample free of clinical cardiovascular disease. METHODS: We examined relationships of leptin, resistin, TNF-α, and adiponectin with RV morphology and function (from cardiac MRI) in participants (n = 1,267) free of clinical cardiovascular disease from the Multi-Ethnic Study of Atherosclerosis (MESA)-RV study...
2015: PloS One
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