keyword
MENU ▼
Read by QxMD icon Read
search

ezh2 liver

keyword
https://www.readbyqxmd.com/read/27721404/a-pre-neoplastic-epigenetic-field-defect-in-hcv-infected-liver-at-transcription-factor-binding-sites-and-polycomb-targets
#1
N A Wijetunga, M Pascual, J Tozour, F Delahaye, M Alani, M Adeyeye, A W Wolkoff, A Verma, J M Greally
The predisposition of patients with Hepatitis C virus (HCV) infection to hepatocellular carcinoma (HCC) involves components of viral infection, inflammation and time. The development of multifocal, genetically distinct tumours is suggestive of a field defect affecting the entire liver. The molecular susceptibility mediating such a field defect is not understood. One potential mediator of long-term cellular reprogramming is heritable (epigenetic) regulation of transcription, exemplified by DNA methylation. We studied epigenetic and transcriptional changes in HCV-infected livers in comparison with control, uninfected livers and HCC, allowing us to identify pre-neoplastic epigenetic and transcriptional events...
October 10, 2016: Oncogene
https://www.readbyqxmd.com/read/27690696/modified-adenovirus-reduces-de-novo-peritoneal-adhesions-in-rats-and-limits-off-target-transfection-role-of-ezh2-in-adhesion-formation
#2
Hussein M Atta, Ayman A Al-Hendy, Salama R Abdel Raheim, Hend Abdel-Ghany, Khalid A Nasif, Ahlam M Abdellah, Nagwa M Zenhom, Heba S Kamel
AIM OF THE STUDY: Adenovector encoding tissue plasminogen activator (tPA) was shown to reduce experimental peritoneal adhesion. We investigated the targeting potential of our modified adenovector, its ability to reduce adhesions and the epigenetic role of histone methyltransferase EZH2 in adhesion formation. MATERIALS AND METHODS: Control lacZ, nonmodified tPA or modified tPA vectors were instilled in the peritoneal cavity after injury in de novo adhesions or after lysis of adhesions in recurrent adhesions...
October 3, 2016: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/27367027/inflammatory-related-gene-ikk%C3%AE-ikk%C3%AE-ikk%C3%AE-cooperates-to-determine-liver-cancer-stem-cells-progression-by-altering-telomere-via-heterochromatin-protein-1-hotair-axis
#3
Jiahui An, Mengying Wu, Xiaoru Xin, Zhuojia Lin, Xiaonan Li, Qidi Zheng, Xin Gui, Tianming Li, Hu Pu, Haiyan Li, Dongdong Lu
Cancer stem cells are associated with tumor recurrence. IKK is a protein kinase that is composed of IKKα, IKKβ, IKKγ. Herein, we demonstrate that IKKα plus IKKβ promoted and IKKγ inhibited liver cancer stem cell growth in vitro and in vivo. Mechanistically, IKKα plus IKKβ enhanced and IKKγ inhibited the interplay among HP1α, HP1β and HP1γ that competes for the interaction among HP1α, SUZ12, HEZ2. Therefore, IKKα plus IKKβ inhibited and IKKγ enhanced the activity of H3K27 methyltransferase SUZ12 and EZH2, which methylates H3K27 immediately sites on HOTAIR promoter region...
June 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27239797/lnc-%C3%AE-catm-elicits-ezh2-dependent-%C3%AE-catenin-stabilization-and-sustains-liver-csc-self-renewal
#4
Pingping Zhu, Yanying Wang, Guanling Huang, Buqing Ye, Benyu Liu, Jiayi Wu, Ying Du, Lei He, Zusen Fan
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and heterogeneity of hepatocellular carcinoma (HCC); however, the molecular mechanisms underlying their self-renewal and differentiation remain largely unknown. Through analysis of transcriptome microarray data, we identified a long noncoding RNA (lncRNA) called lnc-β-Catm, which is highly expressed in human HCC tumors and liver CSCs. We found that lnc-β-Catm is required for self-renewal of liver CSCs and tumor propagation in mice...
July 2016: Nature Structural & Molecular Biology
https://www.readbyqxmd.com/read/27145952/normal-formation-of-a-vertebrate-body-plan-and-loss-of-tissue-maintenance-in-the-absence-of-ezh2
#5
Bilge San, Naomi D Chrispijn, Nadine Wittkopp, Simon J van Heeringen, Anne K Lagendijk, Marco Aben, Jeroen Bakkers, René F Ketting, Leonie M Kamminga
Polycomb group (PcG) proteins are transcriptional repressors of numerous genes, many of which regulate cell cycle progression or developmental processes. We used zebrafish to study Enhancer of zeste homolog 2 (Ezh2), the PcG protein responsible for placing the transcriptional repressive H3K27me3 mark. We identified a nonsense mutant of ezh2 and generated maternal zygotic (MZ) ezh2 mutant embryos. In contrast to knockout mice for PcG proteins, MZezh2 mutant embryos gastrulate seemingly normal, but die around 2 days post fertilization displaying pleiotropic phenotypes...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26848027/enhancer-of-zeste-homolog-2-depletion-arrests-the-proliferation-of-hepatoblastoma-cells
#6
Yue Wang, Yongtao Xiao, Kai Chen, Sheng Chen, Min Zhang, Zhixiang Wu, Yeming Wu
Hepatoblastoma is the most common type of malignant liver tumor in children. While outcomes have been greatly improved in the past decades, the treatment of advanced hepatoblastoma has remained challenging. Enhancer of zeste homologue 2 (EZH2), a member of the polycomb group regulators of gene activity, is amplified and overexpressed in a variety of cancers. However, the role of EZH2 in hepatoblastoma has remained to be fully elucidated. The purpose of the present study was to investigate the expression patterns of EZH2 in hepatoblastoma cells and to assess the anti‑cancer effects of EZH2 depletion...
March 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26773568/ezh2-regulates-the-lin28-let-7-pathway-to-restrict-activation-of-fetal-gene-signature-in-adult-hematopoietic-stem-cells
#7
Motohiko Oshima, Nagisa Hasegawa, Makiko Mochizuki-Kashio, Tomoya Muto, Satoru Miyagi, Shuhei Koide, Shogo Yabata, George Russel Wendt, Atsunori Saraya, Changshan Wang, Kazuya Shimoda, Yutaka Suzuki, Atsushi Iwama
Fetal liver hematopoietic stem cells (HSCs) seed bone marrow (BM) and undergo reprograming into adult-type HSCs that are largely quiescent and restricted in their self-renewal activity. Here we report that in the absence of the polycomb-group gene Ezh2, a cohort of fetal-specific genes, including let-7 target genes, were activated in BM hematopoietic stem/progenitor cells (HSPCs), leading to acquisition of fetal phenotypes by BM HSPCs, such as enhanced self-renewal activity and production of fetal-type lymphocytes...
April 2016: Experimental Hematology
https://www.readbyqxmd.com/read/26693053/genetic-alteration-and-misexpression-of-polycomb-group-genes-in-hepatocellular-carcinoma
#8
Shu-Bin Gao, Shi-Long Sun, Qi-Lin Zheng, Li Zhang, Yuequan Zhu, Guang-Hui Jin, Li-Xiang Xue
Although the abnormal expression of Polycomb-group (PcG) proteins is closely associated with carcinogenesis and the clinicopathological features of hepatocellular carcinoma (HCC), the genetic mutation profile of PcG genes has not been well established. In this study of human HCC specimens, we firstly discovered a highly conserved mutation site, G553C, in the Polycomb Repressive Complex 2 (PRC2) gene enhancer of zeste homolog 2 (EZH2). This site also harbors a single nucleotide polymorphism (SNP), rs2302427, which plays an important antagonistic role in HCC...
2015: American Journal of Cancer Research
https://www.readbyqxmd.com/read/26431491/long-non-coding-rna-profiling-links-subgroup-classification-of-endometrioid-endometrial-carcinomas-with-trithorax-and-polycomb-complex-aberrations
#9
Yunyun Jiang, Gabriel G Malouf, Jianping Zhang, Xiaofeng Zheng, Yunxin Chen, Erika J Thompson, John N Weinstein, Ying Yuan, Jean-Philippe Spano, Russell Broaddus, Nizar M Tannir, David Khayat, Karen H Lu, Xiaoping Su
BACKGROUND: Integrative analysis of endometrioid endometrial carcinoma (EEC) using multiple platforms has distinguished four molecular subgroups. However, the landscape of expressed long non-coding RNAs (lncRNA) and their role in charting EEC subgroups and determining clinical aggressiveness remain largely unknown. RESULTS: Using stringent criteria, we identified 1,931 expressed lncRNAs and predicted potential drivers through integrative analysis. Unsupervised clustering of lncRNA expression revealed three robust categories: basal-like, luminal-like and CTNNB1-enriched subgroups...
November 24, 2015: Oncotarget
https://www.readbyqxmd.com/read/26383163/histone-deacetylase-hdac8-promotes-insulin-resistance-and-%C3%AE-catenin-activation-in-nafld-associated-hepatocellular-carcinoma
#10
Yuan Tian, Vincent W S Wong, Grace L H Wong, Weiqin Yang, Hanyong Sun, Jiayun Shen, Joanna H M Tong, Minnie Y Y Go, Yue S Cheung, Paul B S Lai, Mingyan Zhou, Gang Xu, Tim H M Huang, Jun Yu, Ka F To, Alfred S L Cheng, Henry L Y Chan
The growing epidemic of obesity, which causes nonalcoholic fatty liver disease (NAFLD) and the more severe phenotype nonalcoholic steatohepatitis (NASH), has paralleled the increasing incidence of hepatocellular carcinoma (HCC). Accumulating evidence demonstrates that overnutrition and metabolic pathways can trigger modifications of DNA and histones via deregulation of chromatin modifiers, resulting in aberrant transcriptional activity. However, the epigenetic regulation of HCC development in NAFLD remains obscure...
November 15, 2015: Cancer Research
https://www.readbyqxmd.com/read/26359029/maternal-gestational-betaine-supplementation-mediated-suppression-of-hepatic-cyclin-d2-and-presenilin1-gene-in-newborn-piglets-is-associated-with-epigenetic-regulation-of-the-stat3-dependent-pathway
#11
Demin Cai, Mengjie Yuan, Yimin Jia, Haoyu Liu, Yun Hu, Ruqian Zhao
Betaine, which donates methyl groups through methionine metabolism for DNA and protein methylation, is critical for epigenetic gene regulation, especially during fetal development. Here we fed gestational sows with control or betaine supplemented diets (3 g/kg) throughout the pregnancy to explore the effects of maternal betaine on hepatic cell proliferation in neonatal piglets. Neonatal piglets born to betaine-supplemented sows demonstrated a reduction of cell number and DNA content in the liver, which was associated with significantly down-regulated hepatic expression of cell cycle regulatory genes, cyclin D2 (CCND2) and presenilin1 (PSEN1)...
December 2015: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/26343958/morphophenotypic-changes-in-human-multistep-hepatocarcinogenesis-with-translational-implications
#12
Amedeo Sciarra, Luca Di Tommaso, Masayuki Nakano, Annarita Destro, Guido Torzilli, Matteo Donadon, Marco Maggioni, Silvano Bosari, Gaetano Bulfamante, Masanori Matsuda, Hideki Fujii, Tomoaki Ichikawa, Hiroyuki Morisaka, Katsuhiro Sano, Shintaro Ichikawa, Massimo Roncalli
BACKGROUND & AIMS: Human hepatocarcinogenesis in cirrhosis is thought to be multistep and characterized by a spectrum of nodular lesions, ranging from low to high grade dysplastic nodules (LGDN and HGDN) to early and progressed hepatocellular carcinoma (eHCC and pHCC). The aim of this study was to investigate the morphophenotypical changes of this sequence and their potential translational significance. METHODS: We scored the vascular profile, ductular reaction/stromal invasion and overexpression of five biomarkers (GPC3, HSP70, GS, CHC, and EZH2), in a series of 100 resected nodules (13 LGDN, 16 HGDN, 42 eHCC and 29 small pHCC)...
January 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/25933431/integrative-analysis-of-normal-long-intergenic-non-coding-rnas-in-prostate-cancer
#13
Pushpinder Bawa, Sajna Zackaria, Mohit Verma, Saurabh Gupta, R Srivatsan, Bibha Chaudhary, Subhashini Srinivasan
Recently, large numbers of normal human tissues have been profiled for non-coding RNAs and more than fourteen thousand long intergenic non-coding RNAs (lincRNAs) are found expressed in normal human tissues. The functional roles of these normal lincRNAs (nlincRNAs) in the regulation of protein coding genes in normal and disease biology are yet to be established. Here, we have profiled two RNA-seq datasets including cancer and matched non-neoplastic tissues from 12 individuals from diverse demography for both coding genes and nlincRNAs...
2015: PloS One
https://www.readbyqxmd.com/read/25893293/hepatitis-b-virus-x-protein-induces-epcam-expression-via-active-dna-demethylation-directed-by-rela-in-complex-with-ezh2-and-tet2
#14
H Fan, H Zhang, P E Pascuzzi, O Andrisani
Chronic hepatitis B virus (HBV) infection is a major risk factor for developing hepatocellular carcinoma (HCC), and HBV X protein (HBx) acts as cofactor in hepatocarcinogenesis. In liver tumors from animals modeling HBx- and HBV-mediated hepatocarcinogenesis, downregulation of chromatin regulating proteins SUZ12 and ZNF198 induces expression of several genes, including epithelial cell adhesion molecule (EpCAM). EpCAM upregulation occurs in HBV-mediated HCCs and hepatic cancer stem cells, by a mechanism not understood...
February 11, 2016: Oncogene
https://www.readbyqxmd.com/read/25693145/systemic-delivery-of-microrna-101-potently-inhibits-hepatocellular-carcinoma-in-vivo-by-repressing-multiple-targets
#15
Fang Zheng, Yi-Ji Liao, Mu-Yan Cai, Tian-Hao Liu, Shu-Peng Chen, Pei-Hong Wu, Long Wu, Xiu-Wu Bian, Xin-Yuan Guan, Yi-Xin Zeng, Yun-Fei Yuan, Hsiang-Fu Kung, Dan Xie
Targeted therapy based on adjustment of microRNA (miRNA)s activity takes great promise due to the ability of these small RNAs to modulate cellular behavior. However, the efficacy of miR-101 replacement therapy to hepatocellular carcinoma (HCC) remains unclear. In the current study, we first observed that plasma levels of miR-101 were significantly lower in distant metastatic HCC patients than in HCCs without distant metastasis, and down-regulation of plasma miR-101 predicted a worse disease-free survival (DFS, P<0...
February 2015: PLoS Genetics
https://www.readbyqxmd.com/read/25500144/a-ccrk-ezh2-epigenetic-circuitry-drives-hepatocarcinogenesis-and-associates-with-tumor-recurrence-and-poor-survival-of-patients
#16
Hai Feng, Zhuo Yu, Yuan Tian, Ying-Ying Lee, May S Li, Minnie Y Y Go, Yue-Sun Cheung, Paul B S Lai, Andrew M L Chan, Ka-Fai To, Henry L Y Chan, Joseph J Y Sung, Alfred S L Cheng
BACKGROUND & AIMS: Aberrant chromatin modification is a key feature of hepatocellular carcinoma (HCC), which is characterized by strong sexual dimorphism. Both enhancer of zeste homolog 2 (EZH2) and cell cycle-related kinase (CCRK) contribute to hepatocarcinogenesis, yet whether the two oncogenic factors have functional crosstalk is unknown. METHODS: Cellular proliferation and tumorigenicity upon transgenic expression and RNA interference were determined by colony formation and soft agar assays, xenograft, orthotopic and diethylnitrosamine-induced HCC models...
May 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25494962/mir-26a-promoted-by-interferon-alpha-inhibits-hepatocellular-carcinoma-proliferation-and-migration-by-blocking-ezh2
#17
Gang Wang, Yubei Sun, Yifu He, Chushu Ji, Bing Hu, Yuping Sun
BACKGROUNDS: Interferon (IFN)-α has been used to treat hepatocellular carcinoma (HCC). Here, we report that the IFN-α-induced microRNA-26a (miR-26a) can inhibit HCC proliferation and invasion by suppressing enhancer of zeste homologue 2 (EZH2) expression in tumor cells. MATERIALS AND METHODS: First, the miR-26a transcription level was quantified by real-time quantitative PCR in the HCC specimens from IFN-α-treated HCC patients. Next, we transfected HepG2 cells with miR-26a mimics and miR control, and then we investigated the influence of miR-26a mimic transfection on HepG2 cell proliferation and invasion...
January 2015: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/25477280/the-methyltransferases-enhancer-of-zeste-homolog-ezh-1-and-ezh2-control-hepatocyte-homeostasis-and-regeneration
#18
Woo Kyun Bae, Keunsoo Kang, Ji Hoon Yu, Kyung Hyun Yoo, Valentina M Factor, Kosuke Kaji, Matthias Matter, Snorri Thorgeirsson, Lothar Hennighausen
To investigate the role of enhancer of zeste homolog (EZH) 1 and EZH2 in liver homeostasis, mice were generated that carried Ezh1(-/-) and EZH2(fl/fl) alleles and an Alb-Cre transgene. Only the combined loss of EZH1 and EZH2 in mouse hepatocytes caused a depletion of global trimethylation on Lys 27 of histone H3 (H3K27me3) marks and the specific loss of over ∼1900 genes at 3 mo of age. Ezh1(-/-),Ezh2(fl/fl)Alb-Cre mice exhibited progressive liver abnormalities manifested by the development of regenerative nodules and concomitant periportal fibrosis, inflammatory infiltration, and activation of A6-positive hepatic progenitor cells at 8 mo of age...
May 2015: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/25380300/mutant-mmp-9-and-hgf-gene-transfer-enhance-resolution-of-ccl4-induced-liver-fibrosis-in-rats-role-of-ash1-and-ezh2-methyltransferases-repression
#19
Hussein Atta, Mahmoud El-Rehany, Olfat Hammam, Hend Abdel-Ghany, Maggie Ramzy, Martin Roderfeld, Elke Roeb, Ayman Al-Hendy, Salama Abdel Raheim, Hatem Allam, Heba Marey
UNLABELLED: Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1). It was shown that ASH1 and EZH2 methyltransferases are involved in development of liver fibrosis; however, their role in the resolution phase of liver fibrosis has not been investigated. This study evaluated the role of ASH1 and EZH2 in two mechanistically different therapeutic modalities, HGF and mMMP-9 gene transfer in CCl4 induced rat liver fibrosis...
2014: PloS One
https://www.readbyqxmd.com/read/25289642/cellular-senescence-in-biliary-pathology-special-emphasis-on-expression-of-a-polycomb-group-protein-ezh2-and-a-senescent-marker-p16ink4a-in-bile-ductular-tumors-and-lesions
#20
REVIEW
Motoko Sasaki, Yasuni Nakanuma
A subgroup of intrahepatic cholangiocarcinoma and combined hepatocellular- cholangiocarcinoma contain a component of cholangiolocellular carcinoma, which is composed of small bile ductular cells. Ductular reaction, a reactive lesion at the portal tract interface comprising increased bile ductules, is frequently seen in chronic advanced liver diseases. Bile duct adenoma, a benign tumor/tumorous lesion is also composed of bile ductular cells. Differential diagnosis among these bile ductular tumors/lesions is sometimes difficult...
March 2015: Histology and Histopathology
keyword
keyword
83360
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"