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Alexander V Korovin, Nicolas L Dmitruk, Sergii V Mamykin, Viktor I Myn'ko, Mariya V Sosnova
A new approach to the formation of a 1D planar periodicity on the front of a plasmonic photodetector based on Schottky barrier is proposed. It allows forming a 1D planar periodicity with corrugation at the "metal/environment" interface by laser interference lithography using embedded chalcogenide wires, whereas the "metal/semiconductor" interface is flat that leads to reducing of surface recombination losses at Shottky barrier in contrary to the conventional technology for forming corrugated metal films on the semiconductor surface requiring chemical etching of the semiconductor substrate...
December 2017: Nanoscale Research Letters
Mariya V Sivay, Maoji Li, Estelle Piwowar-Manning, Yinfeng Zhang, Sarah E Hudelson, Mark A Marzinke, Rivet K Amico, Andrew Redd, Craig W Hendrix, Peter L Anderson, Kevin Bokoch, Linda Gail-Bekker, Frits van Griensven, Sharon Mannheimer, James P Hughes, Robert Grant, Susan H Eshleman
BACKGROUND: HPTN 067/ADAPT evaluated tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) pre-exposure prophylaxis (PrEP) in women (South Africa) and men who have sex with men (Thailand, US). Participants received once-weekly directly observed TDF/FTC (DOT), and were then randomized to daily, time-driven, or event-driven PrEP. This report describes characterization of 12 HIV seroconversion events in this trial. METHODS: HIV rapid testing was performed at study sites...
March 22, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Ivan V Chernikov, Daniil V Gladkikh, Mariya I Meschaninova, Alya G Ven'yaminova, Marina A Zenkova, Valentin V Vlassov, Elena L Chernolovskaya
Chemical modifications are an effective way to improve the therapeutic properties of small interfering RNAs (siRNAs), making them more resistant to degradation in serum and ensuring their delivery to target cells and tissues. Here, we studied the carrier-free biodistribution and biological activity of a nuclease-resistant anti-MDR1 cholesterol-siRNA conjugate in healthy and tumor-bearing severe combined immune deficiency (SCID) mice. The attachment of cholesterol to siRNA provided its efficient accumulation in the liver and in tumors, and reduced its retention in the kidneys after intravenous and intraperitoneal injection...
March 17, 2017: Molecular Therapy. Nucleic Acids
Liubomyr S Monastyrskii, Bogdan S Sokolovskii, Mariya P Alekseichyk
The paper theoretically investigates the peculiarities of energy diagram of asymmetric graded-band-gap superlattices with linear coordinate dependences of band gap and electron affinity. For calculating the energy diagram of asymmetric graded-band-gap superlattices, linearized Poisson's equation has been solved for the two layers forming a period of the superlattice. The obtained coordinate dependences of edges of the conduction and valence bands demonstrate substantial transformation of the shape of the energy diagram at changing the period of the lattice and the ratio of width of the adjacent layers...
December 2017: Nanoscale Research Letters
Karen Eastlake, Wendy E Heywood, Dhani Tracey-White, Erika Aquino, Emily Bliss, Gerardo R Vasta, Kevin Mills, Peng T Khaw, Mariya Moosajee, G Astrid Limb
Zebrafish spontaneously regenerate the retina after injury. Although the gene expression profile has been extensively studied in this species during regeneration, this does not reflect protein function. To further understand the regenerative process in the zebrafish, we compared the proteomic profile of the retina during injury and upon regeneration. Using two-dimensional difference gel electrophoresis (2D-DIGE) and label-free quantitative proteomics (quadrupole time of flight LC-MS/MS), we analysed the retina of adult longfin wildtype zebrafish at 0, 3 and 18 days after Ouabain injection...
March 16, 2017: Scientific Reports
Valeryia Kasneryk, Mariya Shamzhy, Maksym Opanasenko, Paul S Wheatley, Samuel A Morris, Samantha E Russell, Alvaro Mayoral, Michal Trachta, Jiří Čejka, Russell E Morris
The assembly-disassembly-organization-reassembly (ADOR) process has been used to disassemble a parent zeolite with the UOV structure type and then reassemble the resulting layers into a novel structure, IPC-12. The structure of the material has previously been predicted computationally and confirmed in our experiments using X-ray diffraction and atomic resolution STEM-HAADF electron microscopy. This is the first successful application of the ADOR process to a material with porous layers.
March 13, 2017: Angewandte Chemie
Alexander Bogaychuk, Andrey Zyubin, Anastasiya Lavrova, Galina Kupriyanova, Svetlana Babak, Mariya Dambieva, Maksim Demin, Anastasiya Borisova, Nikita Opryshko
This article contains NMR (nuclear magnetic resonance) experimental data, obtained by the NMR Varian 400 MHz spectrometer (USA) which can be used for the metabolites identification in human blood. Data include analyzed NMR spectra of plasma proteins extracted from human blood of 24 patients (0-5 years old) with the confirmed acute leukemia diagnosis. Data can provide information about metabolites and their concentration in blood.
April 2017: Data in Brief
Camilla Schinner, Franziska Vielmuth, Vera Rötzer, Matthias Hiermaier, Mariya Radeva, Thu K Co, Eva Hartlieb, Andreas Schmidt, Axel Imhof, Ahmed Messoudi, Anja Horn, Angela Schlipp, Volker Spindler, Jens Waschke
Rationale: The sympathetic nervous system is a major mediator of heart function. Intercalated discs (ICDs) composed of desmosomes, adherens junctions and gap junctions provide the structural backbone for coordinated contraction of cardiac myocytes. Objective: Gap junctions dynamically remodel to adapt to sympathetic signaling. However, it is unknown whether such rapid adaption also occurs for the adhesive function provided by desmosomes and adherens junctions. Methods and Results: Atomic force microscopy revealed that β-adrenergic signaling enhances both the number of desmoglein 2 (Dsg2) -specific interactions along cell junctions and the mean Dsg2-mediated binding forces, whereas N-cadherin-mediated interactions were not affected...
March 13, 2017: Circulation Research
Uzma Salar, Khalid Mohammed Khan, Jamshed Iqbal, Syeda Abida Ejaz, Abdul Hameed, Mariya Al-Rashida, Shahnaz Perveen, Muhammad Nawaz Tahir
A library of coumarin derived sulfonyl esters (1-38) was synthesized by reacting various hydroxy coumarins with different alkyl and aryl sulfonyl chlorides. All compounds were evaluated for their potential to inhibit alkaline phosphatases (hTNAP and hIAP). Most of the compounds were found to be inhibitors of APs. Compound 20 was found to be the most active hIAP inhibitor (IC50 = 1.11 ± 0.15 μM), whereas, compound 13 was found to be the most active hTNAP inhibitor (IC50 = 0.58 ± 0.17 μM). Detailed structure activity relationship studies (SAR), and molecular docking studies were carried out to identify structural elements necessary for AP inhibition, in addition to rationalize most probable binding site interaction of the inhibitors with the AP enzymes...
March 6, 2017: European Journal of Medicinal Chemistry
Dmitry Miroshnichenko, Inna Chaban, Mariya Chernobrovkina, Sergey Dolgov
Einkorn (Triticum monococcum L.) is A-genome diploid wheat that has a potential to become a useful model for understanding the biology and genomics in Triticeae. Unfortunately, the application of modern technologies such as genetic engineering, RNAi-based gene silencing and genome editing is not available for einkorn as there is no efficient in vitro tissue culture and plant regeneration system. In the present study an efficient and simple protocol for plant regeneration via direct or indirect somatic embryogenesis and organogenesis has been developed...
2017: PloS One
Mariya Gugel, Amanda R Taylor, Jessica J Bailey, Jennifer W Koehler
No abstract text is available yet for this article.
March 15, 2017: Journal of the American Veterinary Medical Association
Faryal Chaudhry, Abdul Qayuum Ather, Mohammad Javaid Akhtar, Ayesha Shaukat, Mohammad Ashraf, Mariya Al-Rashida, Munawar Ali Munawar, Misbahul Ain Khan
An efficient and environmentally benign simple fusion reaction of 3-chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine (1a) or 3-chloro-6-(3,5-dimethyl-4-nitro-1H-pyrazol-1-yl)pyridazine (2a) with different aliphatic/aromatic amines have produced a series of novel pyrazolylpyridazine amines (4a-4c &5a-5m). All compounds exhibited moderate in vitro yeast α-glucosidase inhibition except m-chloro derivative 5g, which was found potent inhibitor of this enzyme with IC50 value of 19.27±0.005µM. The molecular docking further helped in understanding the structure activity relationship of these compounds including 5g...
February 9, 2017: Bioorganic Chemistry
Ryota Horibe, Yoshihiko Hirohashi, Takuya Asano, Tasuku Mariya, Takeshi Suzuki, Akari Takaya, Hiroshi Saijo, Yosuke Shionoya, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Kazue Watanabe, Eri Atsuyama, Shingo Toji, Hiroshi Hirano, Tadashi Hasegawa, Hiroki Takahashi, Noriyuki Sato, Toshihiko Torigoe
Lung cancer is one of the most common malignancies with a high rate of mortality. Lung cancer stem-like cells (CSCs)/ cancer-initiating cells (CICs) play major role in resistance to treatments, recurrence and distant metastasis and eradication of CSCs/CICs is crucial to improve recent therapy. Cytotoxic T lymphocytes (CTLs) are major effectors of cancer immunotherapy, and CTLs recognize antigenic peptides derived from antigens that are presented by major histocompatibility complex (MHC) class I molecules. In this study, we analyzed the potency of a cancer-testis (CT) antigen, brother of the regulator of the imprinted site variant subfamily 6 (BORIS sf6), in lung CSC/CIC immunotherapy...
2017: PloS One
John S Schardt, Jinan M Oubaid, Sonya C Williams, James L Howard, Chloe M Aloimonos, Michelle L Bookstaver, Tek N Lamichhane, Sonja Sokic, Mariya S Liyasova, Maura O'Neill, Thorkell Andresson, Arif Hussain, Stanley Lipkowitz, Steven M Jay
The receptor tyrosine kinase HER3 has emerged as a therapeutic target in ovarian, prostate, breast, lung, and other cancers due to its ability to potently activate the PI3K/Akt pathway, especially via dimerization with HER2, as well as for its role in mediating drug resistance. Enhanced efficacy of HER3-targeted therapeutics would therefore benefit a wide range of patients. This study evaluated the potential of multivalent presentation, through protein engineering, to enhance the effectiveness of HER3-targeted affibodies as alternatives to monoclonal antibody therapeutics...
March 8, 2017: Molecular Pharmaceutics
Mariya Y Marusina, Alexandra P Mochalina, Ekaterina P Frolova, Valentin I Satikov, Anton A Barchuk, Vladimir I Kuznetcov, Vadim S Gaidukov, Segrey A Tarakanov
Background: Cancer is one of the most common causes of human mortality, with about 14 million new cases and 8.2 million deaths reported in in 2012. Early diagnosis of cancer through screening allows interventions to reduce mortality. Fractal analysis of medical images may be useful for this purpose. Materials and Methods: In this study, we examined magnetic resonance (MR) images of healthy livers and livers containing metastases from colorectal cancer. The fractal dimension and the Hurst exponent were chosen as diagnostic features for tomographic imaging using Image J software package for image processings FracLac for applied for fractal analysis with a 120x150 pixel area...
January 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
Jennifer Ledon, Mariya Miteva
No abstract text is available yet for this article.
March 2017: Journal of Investigative Dermatology
Mariya Y Radeva, Jens Waschke
The endothelial barrier consists of intercellular contacts localized in the cleft between endothelial cells, which is covered by the glycocalyx in a sieve-like manner. Both types of barrier-forming junctions, i.e. the adherens junction (AJ) serving mechanical anchorage and mechanotransduction and the tight junction (TJ) sealing the intercellular space to limit paracelullar permeability, are tethered to the actin cytoskeleton. Under resting conditions, the endothelium thereby builds a selective layer controlling the exchange of fluid and solutes with the surrounding tissue...
February 23, 2017: Acta Physiologica
Mariya Doneva, Thomas Amthor, Peter Koken, Karsten Sommer, Peter Börnert
An iterative reconstruction method for undersampled magnetic resonance fingerprinting data is presented. The method performs the reconstruction entirely in k-space and is related to low rank matrix completion methods. A low dimensional data subspace is estimated from a small number of k-space locations fully sampled in the temporal direction and used to reconstruct the missing k-space samples before MRF dictionary matching. Performing the iterations in k-space eliminates the need for applying a forward and an inverse Fourier transform in each iteration required in previously proposed iterative reconstruction methods for undersampled MRF data...
February 18, 2017: Magnetic Resonance Imaging
Remington R S Schneider, Diana G Eng, J Nathan Kutz, Mariya T Sweetwyne, Jeffrey W Pippin, Stuart J Shankland
Advanced age portends a poorer prognosis in FSGS. To understand the impact of age on glomerular podocytes and parietal epithelial cells (PECs), experimental FSGS was induced in 3m-old mice (20-year old human age) and 27m-old mice (78-year old human age) by abruptly depleting podocytes with a cytopathic anti-podocyte antibody. Despite similar binding of the disease-inducing antibody, podocyte density was lower in aged FSGS mice compared to young FSGS mice. Activated PEC density was higher in aged versus young FSGS mice, as was the percentage of total activated PECs...
February 17, 2017: Aging
Jitendra S Kanshana, Vivek Khanna, Vishal Singh, Manish Jain, Ankita Misra, Sachin Kumar, Mariya Farooqui, Manoj K Barthwal, Madhu Dikshit
OBJECTIVE: Although atherosclerosis is described in New Zealand White rabbit's iliac artery, yet details of time-dependent atherosclerosis progression are not well known. Further, a well characterized accelerated model of atherosclerosis is also required for the screening of candidate drugs to target specific steps of atherosclerosis development. The present study extensively characterizes the time-dependent plaque composition and functional responses of the atherosclerosis in rabbit iliac artery and its modification by simvastatin...
February 14, 2017: Journal of Cardiovascular Pharmacology
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