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https://www.readbyqxmd.com/read/28231640/mind-the-gap-mechanisms-regulating-the-endothelial-barrier
#1
REVIEW
Mariya Y Radeva, Jens Waschke
The endothelial barrier consists of intercellular contacts localized in the cleft between endothelial cells, which is covered by the glycocalyx in a sieve-like manner. Both types of barrier-forming junctions, i.e. the adherens junction (AJ) serving mechanical anchorage and mechanotransduction and the tight junction (TJ) sealing the intercellular space to limit paracelullar permeability, are tethered to the actin cytoskeleton. Under resting conditions, the endothelium thereby builds a selective layer controlling the exchange of fluid and solutes with the surrounding tissue...
February 23, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28223063/matrix-completion-based-reconstruction-for-undersampled-magnetic-resonance-fingerprinting-data
#2
Mariya Doneva, Thomas Amthor, Peter Koken, Karsten Sommer, Peter Börnert
An iterative reconstruction method for undersampled magnetic resonance fingerprinting data is presented. The method performs the reconstruction entirely in k-space and is related to low rank matrix completion methods. A low dimensional data subspace is estimated from a small number of k-space locations fully sampled in the temporal direction and used to reconstruct the missing k-space samples before MRF dictionary matching. Performing the iterations in k-space eliminates the need for applying a forward and an inverse Fourier transform in each iteration required in previously proposed iterative reconstruction methods for undersampled MRF data...
February 18, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28222042/compound-effects-of-aging-and-experimental-fsgs-on-glomerular-epithelial-cells
#3
Remington R S Schneider, Diana G Eng, J Nathan Kutz, Mariya T Sweetwyne, Jeffrey W Pippin, Stuart J Shankland
Advanced age portends a poorer prognosis in FSGS. To understand the impact of age on glomerular podocytes and parietal epithelial cells (PECs), experimental FSGS was induced in 3m-old mice (20-year old human age) and 27m-old mice (78-year old human age) by abruptly depleting podocytes with a cytopathic anti-podocyte antibody. Despite similar binding of the disease-inducing antibody, podocyte density was lower in aged FSGS mice compared to young FSGS mice. Activated PEC density was higher in aged versus young FSGS mice, as was the percentage of total activated PECs...
February 17, 2017: Aging
https://www.readbyqxmd.com/read/28207427/progression-and-characterization-of-the-accelerated-atherosclerosis-in-iliac-artery-of-new-zealand-white-rabbits-effect-of-simvastatin
#4
Jitendra S Kanshana, Vivek Khanna, Vishal Singh, Manish Jain, Ankita Misra, Sachin Kumar, Mariya Farooqui, Manoj K Barthwal, Madhu Dikshit
OBJECTIVE: Although atherosclerosis is described in New Zealand White rabbit's iliac artery, yet details of time-dependent atherosclerosis progression are not well known. Further, a well characterized accelerated model of atherosclerosis is also required for the screening of candidate drugs to target specific steps of atherosclerosis development. The present study extensively characterizes the time-dependent plaque composition and functional responses of the atherosclerosis in rabbit iliac artery and its modification by simvastatin...
February 14, 2017: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/28198529/differences-of-craniotype-distribution-and-types-of-face-among-almost-healthy-men-from-different-regions-of-ukraine
#5
Igor Gunas, Mariya Shinkaruk-Dykovytska, Olga Kotsyura, Volodymir Orlovskiy, Svitlana Dmytrenko, Alla Shayuk, Olena Glushak
Established peculiarities of craniotypes distribution and types of faces in somatic healthy men, depending on regional affiliation. In all regions of Ukraine marked greater brachycephaly percentage, indicating the trend of brachycephalisation and prevalence percentage of men with narrow, very narrow face that confirms gracilization. Marked a small number of regional differences in the distribution of certain types of skull and face, indicating that the population of Ukraine is very homogeneous in anthropological composition and each of the presented Ukrainian regional types not beyond anthropological type, common to people in general...
February 15, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28197274/early-changes-in-the-antithrombin-and-thrombin-antithrombin-complex-in-patients-with-paroxysmal-atrial-fibrillation
#6
Mariya Negreva, Svetoslav Georgiev, Krasimira Prodanova, Julia Nikolova
BACKGROUND: Data on coagulation changes in paroxysmal atrial fibrillation (PAF) are scarce. The aim of this study was to examine plasma antithrombin (AT) levels and activity as well as thrombin-antithrombin (TAT) complex levels in the early hours of the clinical manifestation of PAF. METHODS: Fifty-one patients (26 men and 25 women; mean age 59.84 ± 1.60 years) were consecutively selected with PAF duration < 24 hours, and 52 controls (26 men and 26 women; mean age 59...
June 2016: Cardiology Research
https://www.readbyqxmd.com/read/28193901/exceedingly-small-iron-oxide-nanoparticles-as-positive-mri-contrast-agents
#7
He Wei, Oliver T Bruns, Michael G Kaul, Eric C Hansen, Mariya Barch, Agata Wiśniowska, Ou Chen, Yue Chen, Nan Li, Satoshi Okada, Jose M Cordero, Markus Heine, Christian T Farrar, Daniel M Montana, Gerhard Adam, Harald Ittrich, Alan Jasanoff, Peter Nielsen, Moungi G Bawendi
Medical imaging is routine in the diagnosis and staging of a wide range of medical conditions. In particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with over 60 million MRI procedures performed each year worldwide. About one-third of these procedures are contrast-enhanced MRI, and gadolinium-based contrast agents (GBCAs) are the mainstream MRI contrast agents used in the clinic. GBCAs have shown efficacy and are safe to use with most patients; however, some GBCAs have a small risk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable condition recently linked to gadolinium (Gd) exposure during MRI with contrast...
February 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28183599/electrospun-curcumin-loaded-cellulose-acetate-polyvinylpyrrolidone-fibrous-materials-with-complex-architecture-and-antibacterial-activity
#8
Petya B Tsekova, Mariya G Spasova, Nevena E Manolova, Nadya D Markova, Iliya B Rashkov
Novel fibrous materials from cellulose acetate (CA) and polyvinylpyrrolidone (PVP) containing curcumin (Curc) with original design were prepared by one-pot electrospinning or dual spinneret electrospinning. The electrospun materials were characterized by scanning electron microscopy (SEM), fluorescence microscopy, Fourier transform infrared spectroscopy (FTIR), ultraviolet-visible spectroscopy (UV-Vis), differential scanning calorimetry (DSC), water contact angle measurements, and microbiological tests. It was found that the incorporation of Curc into the CA and PVP solutions resulted in an increase of the solution viscosity and obtaining fibers with larger diameters (ca...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28181738/a-comparison-of-the-effects-of-diets-high-in-animal-or-plant-protein-on-metabolic-and-cardiovascular-markers-in-type-2-diabetes-a-randomized-clinical-trial
#9
Stephanie Sucher, Mariya Markova, Silke Hornemann, Olga Pivovarova, Natalia Rudovich, Ralph Thomann, Rosemarie Schneeweiss, Sascha Rohn, Andreas F H Pfeiffer
AIMS: High animal protein diets support body weight and glucose control but may induce insulin resistance and type 2 diabetes (T2DM) while plant protein based diets appear to be metabolically advantageous and reduce cardiovascular events. We therefore compared high animal versus plant protein diets differing in amino acid composition in people with T2DM. MATERIALS AND METHODS: We compared isocaloric diets containing 30% of energy (E%) either as animal (AP) or plant (PP) protein, using newly developed plant protein enriched foods, both combined with 30 E% fat and 40 E% carbohydrates in 44 patients with T2DM over six weeks in a randomized parallel group study...
February 9, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28173864/macrophage-activation-and-polarization-in-post-infarction-cardiac-remodeling
#10
REVIEW
Aleksandra Gombozhapova, Yuliya Rogovskaya, Vladimir Shurupov, Mariya Rebenkova, Julia Kzhyshkowska, Sergey V Popov, Rostislav S Karpov, Vyacheslav Ryabov
Adverse cardiac remodeling leads to impaired ventricular function and heart failure, remaining a major cause of mortality and morbidity in patients with acute myocardial infarction. It have been shown that, even if all the recommended therapies for ST-segment elevation myocardial infarction are performed, one third of patients undergoes progressive cardiac remodeling that represents morphological basis for following heart failure. The need to extend our knowledge about factors leading to different clinical scenarios of myocardial infarction and following complications has resulted in a research of immuno-inflammatory pathways and molecular activities as the basis for post-infarction remodeling...
February 7, 2017: Journal of Biomedical Science
https://www.readbyqxmd.com/read/28173763/risk-factors-for-poor-multidrug-resistant-tuberculosis-treatment-outcomes-in-kyiv-oblast-ukraine
#11
Omowunmi Aibana, Mariya Bachmaha, Viatcheslav Krasiuk, Natasha Rybak, Timothy P Flanigan, Vasyl Petrenko, Megan B Murray
BACKGROUND: Ukraine is among ten countries with the highest burden of multidrug- resistant TB (MDR-TB) worldwide. Treatment success rates for MDR-TB in Ukraine remain below global success rates as reported by the World Health Organization. Few studies have evaluated predictors of poor MDR-TB outcomes in Ukraine. METHODS: We conducted a retrospective analysis of patients initiated on MDR-TB treatment in the Kyiv Oblast of Ukraine between January 01, 2012 and March 31st, 2015...
February 7, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28166180/therapeutic-vaccine-against-primate-papillomavirus-infections-of-the-cervix
#12
Emeline Ragonnaud, Anne-Marie C Andersson, Silmi Mariya, Anders G Pedersen, Robert D Burk, Antonella Folgori, Stefano Colloca, Riccardo Cortese, Alfredo Nicosia, Joko Pamungkas, Diah Iskandriati, Peter J Holst
Currently available prophylactic vaccines have no therapeutic efficacy for preexisting human papillomavirus (HPVs) infections, do not target all oncogenic HPVs and are insufficient to eliminate the burden of HPV induced cancer. We aim to develop an alternative HPV vaccine which is broadly effective and capable of clearing preexisting infection. In an initial attempt to develop a broadly reactive therapeutic vaccine, we designed a putative papillomavirus (PV) ancestor antigen (circulating sequence derived antigenic sequences E1E2-CDSE1E2) based on the conserved E1 and E2 protein sequences from existing oncogenic HPV strains...
February 2017: Journal of Immunotherapy
https://www.readbyqxmd.com/read/28160945/in-search-of-new-%C3%AE-glucosidase-inhibitors-imidazolylpyrazole-derivatives
#13
Faryal Chaudhry, Sadia Naureen, Rahila Huma, Ayesha Shaukat, Mariya Al-Rashida, Nadia Asif, Mohammad Ashraf, Munawar Ali Munawar, Misbahul Ain Khan
Under three different reaction conditions (conventional heating, microwave irradiations and amino acid catalysis), a series of imidazolylpyrazoles (2a-2k) were synthesized in good to excellent yields from a mixture of three precursors: aryl(hetaryl)pyrazole-4-carbaldehydes (1a-1k), benzil and ammonium acetate. α-Glucosidase inhibition assay revealed a new class of highly potent agents wherein each compound displayed significant inhibitory potentials (in terms of percentage inhibition and relative IC50 values) as compared to that of the reference drug (Acarbose)...
January 23, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28155072/challenges-in-determining-intrinsic-viscosity-under-low-ionic-strength-solution-conditions
#14
Mariya A Pindrus, Steven J Shire, Sandeep Yadav, Devendra S Kalonia
PURPOSE: To determine the intrinsic viscosity of several monoclonal antibodies (mAbs) under varying pH and ionic strength solution conditions. METHODS: An online viscosity detector attached to HPLC (Viscotek®) was used to determine the intrinsic viscosity of mAbs. The Ross and Minton equation was used for viscosity prediction at high protein concentrations. Bulk viscosity was determined by a Cambridge viscometer. RESULTS: At 15 mM ionic strength, intrinsic viscosity of the mAbs determined by the single-point approach varied from 5...
February 2, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28152476/the-efficacy-of-sulfated-polysaccharides-from-padina-tetrastromatica-in-modulating-the-immune-functions-of-raw-264-7-cells
#15
Geena Mariya Jose, G Muraleedhara Kurup
Immunomodulation is a collective term of immunostimulation and immunosuppression. Immunotherapy by means of immunomodulation is gaining additional significance as the frequency of mutant microbes as well as cancer cases are increasing in the present time. A wide population of marine vegetation has contributed to the traditional and modern therapeutic regimens owing to the abundance of bioactive molecules. Among the seaweed born macromolecules, the sulfated polysaccharides (SPS) from marine macro algae were reported to exhibit excellent biological activities in addition to their structural and nutritional roles...
January 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28139246/facile-dimethyl-amino-group-triggered-cyclic-sulfonamides-synthesis-and-evaluation-as-alkaline-phosphatase-inhibitors
#16
Huma Aslam Bhatti, Memoona Khatoon, Mariya Al-Rashida, Huma Bano, Nafees Iqbal, Zaib-Un-Nisa, Sammer Yousuf, Khalid Mohammed Khan, Abdul Hameed, Jamshed Iqbal
Owing to the biological importance of cyclic sulfonamides (sultams), herein we report a new, facile and cost-effective method for the synthesis of sultams that makes use of a reaction between dansyl amide and easily accessible benzaldehydes under mildly acidic conditions. All compounds were obtained in good yields (69-96%). Consequently a series of cyclic sulfonamides (7a-7n) was synthesized and characterized using FTIR, MS and NMR spectroscopy, crystal structure of compound 7b has also been determined. All compounds were evaluated for their potential to inhibit alkaline phosphatase (bTNAP and bIAP)...
January 18, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28114587/transcorneal-electrical-stimulation-for-patients-with-retinitis-pigmentosa-a-prospective-randomized-sham-controlled-follow-up-study-over-1-year
#17
Andreas Schatz, Johanna Pach, Mariya Gosheva, Lubka Naycheva, Gabriel Willmann, Barbara Wilhelm, Tobias Peters, Karl Ulrich Bartz-Schmidt, Eberhart Zrenner, André Messias, Florian Gekeler
Purpose: After promising results of an exploratory study, this study was designed to assess the safety and efficacy of transcorneal electrical stimulation (TES) over 1 year in patients with retinitis pigmentosa (RP). Methods: We included 52 RP patients in this prospective, randomized, partially-masked study which was done in accordance with rules of good clinical practice. Transcorneal electrical stimulation by Okustim was applied monocularly for 30 minutes per week for 52 consecutive weeks...
January 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28110713/snapshotdx-quiz-february-2017
#18
Katherine Nolan, Mariya Miteva
No abstract text is available yet for this article.
February 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28107747/diversity-of-dna-viruses-in-effluents-of-membrane-bioreactors-in-traverse-city-mi-usa-and-la-grande-motte-france
#19
Evan O'Brien, Mariya Munir, Terence Marsh, Marc Heran, Geoffroy Lesage, Volodymyr V Tarabara, Irene Xagoraraki
This study assesses diversity of DNA viruses in the effluents of two membrane bioreactor (MBR) wastewater treatment plants (WWTPs): an MBR in the United States and an MBR in France. Viral diversity of these effluents is compared to that of a conventional activated sludge WWTP in the U.S. Diversity analysis indicates Herpesvirales to be the most abundant order of potentially pathogenic human DNA viruses in wastewater treated effluent in all utilities. Other potentially pathogenic human viruses detected include Adenoviridae, Parvoviridae, and Polyomaviridae...
January 8, 2017: Water Research
https://www.readbyqxmd.com/read/28098148/clinical-utility-gene-card-for-non-syndromic-microphthalmia-including-next-generation-sequencing-based-approaches
#20
Rose Richardson, Jane Sowden, Christina Gerth-Kahlert, Anthony T Moore, Mariya Moosajee
No abstract text is available yet for this article.
January 18, 2017: European Journal of Human Genetics: EJHG
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