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https://www.readbyqxmd.com/read/28648876/triple-negative-invasive-lobular-carcinoma-of-the-breast-presents-as-small-bowel-obstruction
#1
Mariya Khokhlova, Heidi Roppelt, Bradley Gluck, Jingxuan Liu, Kester Haye, Sang Pak, Edna Kapenhas
Metastasis from breast carcinoma to the gastrointestinal tract (GIT) is very uncommon. To date, only a few cases have been described worldwide. Of those which do metastasize to the GIT, only estrogen receptor (ER), progesterone receptor (PR) and HER2-neu receptor positive cancers have been reported and none have been mentioned in the U.S. We report a case of a 70-year-old white female with history of triple negative lobular carcinoma eight years earlier who presented with solitary jejunal mass causing obstruction...
June 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28647029/snapshotdx-quiz-july-2017
#2
Argentina Leon, Mariya Miteva
No abstract text is available yet for this article.
July 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28632948/nodular-cutaneous-amyloidoma-of-the-extremity-secondary-to-chronic-granulomatous-inflammation-in-setting-of-sarcoidosis
#3
Victoria Billero, Audrey A Jacobsen, Mariya I Miteva, Adam J Wulkan, Claudio Marasca, Roanelli Paolo
Soft tissue amyloidoma is a rare condition that presents primarily in the abdomen and/or mediastinum and more uncommonly on the extremities(1) . Soft tissue amyloidomas on the extremities have been associated with chronic inflammation, particularly when accompanied by AA-type amyloid deposition as seen in local trauma, surgery, hypertension, and diabetes(2) . To our knowledge, this is the first reported case of nodular cutaneous amyloidoma in the setting of systemic and cutaneous sarcoidosis. A 65-year-old woman presented with an asymptomatic subcutaneous nodule above her left lateral malleolus...
June 20, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28631421/impact-of-synthetic-cannabinoids-on-the-duration-of-opioid-related-withdrawal-and-craving-among-patients-of-addiction-clinics-in-kazakhstan-a-prospective-case-control-study
#4
Mariya Prilutskaya, Francesco Saverio Bersani, Ornella Corazza, Sergey Molchanov
OBJECTIVE: The aim of the study was to prospectively assess whether regular use of synthetic cannabinoids (SCs) affects the duration of opioid-related withdrawal and craving symptoms in patients undergoing drug detoxification treatments. METHODS: Patients (n = 193) with opioid use disorder, among which 47 patients are regularly using SCs, underwent integrated drug detoxification therapies. The Clinical Opiate Withdrawal Scale and a specific visual analogue scale were used to assess opioid withdrawal and craving symptoms over time...
June 20, 2017: Human Psychopharmacology
https://www.readbyqxmd.com/read/28623996/functional-polymorphism-rs1024611-in-the-mcp1-gene-is-associated-with-the-risk-of-varicose-veins-of-lower-extremities
#5
Alexandra S Shadrina, Mariya A Smetanina, Kseniya S Sevost'ianova, Evgenii I Seliverstov, Evgeny A Ilyukhin, Elena N Voronina, Igor A Zolotukhin, Maxim L Filipenko
OBJECTIVE: Monocyte chemoattractant protein 1 (MCP-1) is a chemokine responsible for monocyte, basophil, and T-lymphocyte attraction. Polymorphism rs1024611 located in the regulatory region of the MCP1 gene has previously been shown to be associated with increased MCP-1 production. In our study, we aimed to examine the association of rs1024611 with the risk of primary varicose veins (PVVs) of lower extremities. METHODS: The case group comprised 470 patients with PVVs, and the control group included 269 individuals without a history of chronic venous disease...
July 2017: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/28619498/microsurgical-treatment-of-colloid-cysts-of-the-third-ventricle
#6
Alexander N Konovalov, David I Pitskhelauri, Michael Shkarubo, Svetlana B Buklina, Anna A Poddubskaya, Mariya Kolycheva
No abstract text is available yet for this article.
June 12, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28606645/detection-of-causative-agents-of-tick-borne-rickettsioses-in-western-siberia-russia-identification-of-rickettsia-raoultii-and-rickettsia-sibirica-dna-in-clinical-samples
#7
Igolkina Yana, Krasnova Elena, Rar Vera, Savelieva Mariya, Epikhina Tamara, Tikunov Artem, Khokhlova Natalya, Provorova Veronika, Tikunova Nina
OBJECTIVES: The main causative agent of tick-borne rickettsioses in Siberia is considered to be Rickettsia sibirica; however, only a few cases have been genetically confirmed. Other pathogenic species of Rickettsia have also been detected in ixodid ticks in Western Siberia. The aim of this study was to detect the etiologic agents of tick-borne rickettsioses in Western Siberia and compare their clinical manifestations. METHODS: A total of 273 blood and 44 cerebrospinal fluid (CSF) samples from 273 patients hospitalized owing to tick-transmitted infection in 2016, April-September, were examined for the presence of Rickettsia spp...
June 9, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28595477/positive-effects-of-plantar-vibration-training-for-the-treatment-of-diabetic-peripheral-neuropathy-a-pilot-study
#8
Katerina Stambolieva, Dorina Petrova, Mariya Irikeva
PURPOSE: To evaluate the effectiveness of 8-week low-frequency plantar vibration training on patients with sensorimotor diabetic peripheral neuropathy (DPN). PARTICIPANTS: Twelve patients took part in the investigation. RESULTS: An increase of the nerve conductive velocity of soral and peroneal nerves of feet, increased postural stability, and disappearance of the pain and tingling were observed. CONCLUSION: The obtained results provide evidence for beneficial effects of 8-week plantar vibration training in patients with DPN...
June 9, 2017: Somatosensory & Motor Research
https://www.readbyqxmd.com/read/28595296/impact-of-time-interval-and-dose-rate-on-cell-survival-following-low-dose-fractionated-exposures
#9
Shingo Terashima, Yoichiro Hosokawa, Eichi Tsuruga, Yasushi Mariya, Toshiya Nakamura
Enhanced cell lethality, also known as hyper-radiosensitivity, has been reported at low doses of radiation (≤0.5 Gy) in various cell lines, and is expected to be an effective cancer therapy. We conducted this study to examine the impact of time interval and dose rate of low-dose fractionated exposures with a short time interval. We evaluated the cell-survival rates of V79 and A549 cells using clonogenic assays. We performed fractionated exposures in unit doses of 0.25, 0.5, 1.0 and 2.0 Gy. We exposed the cells to 2 Gy of X-rays (i) at dose-rates of 1...
June 8, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28592545/development-of-a-web-tool-for-escherichia-coli-sub-typing-based-on-fimh-alleles
#10
Louise Roer, Veronika Tchesnokova, Rosa Allesøe, Mariya Muradova, Sujay Chattopadhyay, Johanne Ahrenfeldt, Martin C F Thomsen, Ole Lund, Frank Hansen, Anette M Hammerum, Evgeni Sokurenko, Henrik Hasman
The aim of this study was to construct a valid publicly available method for in silico fimH sub-typing of Escherichia coli particularly suitable for differentiation of fine-resolution subgroups within clonal groups defined by standard multi-locus sequence typing (MLST). FimTyper was constructed as a FASTA database containing all currently known fimH alleles. The software source code is publicly available on https://bitbucket.org/genomicepidemiology/fimtyper, the database freely available at https://bitbucket...
June 7, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28588126/differences-in-subependymal-vein-anatomy-may-predispose-preterm-infants-to-gmh-ivh
#11
Domenico Tortora, Mariasavina Severino, Mariya Malova, Alessandro Parodi, Giovanni Morana, Jan Sedlacik, Paul Govaert, Joseph J Volpe, Andrea Rossi, Luca Antonio Ramenghi
BACKGROUND AND PURPOSE: The anatomy of the deep venous system plays an important role in the pathogenesis of brain lesions in the preterm brain as shown by different histological studies. The aims of this study were to compare the subependymal vein anatomy of preterm neonates with germinal matrix haemorrhage-intraventricular haemorrhage (GMH-IVH), as evaluated by susceptibility-weighted imaging (SWI) venography, with a group of age-matched controls with normal brain MRI, and to explore the relationship between the anatomical features of subependymal veins and clinical risk factors for GMH-IVH...
June 6, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28587234/peptidylarginine-deiminases-roles-in-cancer-and-neurodegeneration-and-possible-avenues-for-therapeutic-intervention-via-modulation-of-exosome-and-microvesicle-emv-release
#12
REVIEW
Sigrun Lange, Mark Gallagher, Sharad Kholia, Uchini S Kosgodage, Mariya Hristova, John Hardy, Jameel M Inal
Exosomes and microvesicles (EMVs) are lipid bilayer-enclosed structures released from cells and participate in cell-to-cell communication via transport of biological molecules. EMVs play important roles in various pathologies, including cancer and neurodegeneration. The regulation of EMV biogenesis is thus of great importance and novel ways for manipulating their release from cells have recently been highlighted. One of the pathways involved in EMV shedding is driven by peptidylarginine deiminase (PAD) mediated post-translational protein deimination, which is calcium-dependent and affects cytoskeletal rearrangement amongst other things...
June 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28587095/comparative-study-of-lectin-domains-in-model-species-new-insights-into-evolutionary-dynamics
#13
Sofie Van Holle, Kristof De Schutter, Lore Eggermont, Mariya Tsaneva, Liuyi Dang, Els J M Van Damme
Lectins are present throughout the plant kingdom and are reported to be involved in diverse biological processes. In this study, we provide a comparative analysis of the lectin families from model species in a phylogenetic framework. The analysis focuses on the different plant lectin domains identified in five representative core angiosperm genomes (Arabidopsisthaliana, Glycine max, Cucumis sativus, Oryza sativa ssp. japonica and Oryza sativa ssp. indica). The genomes were screened for genes encoding lectin domains using a combination of Basic Local Alignment Search Tool (BLAST), hidden Markov models, and InterProScan analysis...
May 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28560587/evolutionary-relationships-and-expression-analysis-of-eul-domain-proteins-in-rice-oryza-sativa
#14
Kristof De Schutter, Mariya Tsaneva, Shubhada R Kulkarni, Pierre Rougé, Klaas Vandepoele, Els J M Van Damme
BACKGROUND: Lectins, defined as 'Proteins that can recognize and bind specific carbohydrate structures', are widespread among all kingdoms of life and play an important role in various biological processes in the cell. Most plant lectins are involved in stress signaling and/or defense. The family of Euonymus-related lectins (EULs) represents a group of stress-related lectins composed of one or two EUL domains. The latter protein domain is unique in that it is ubiquitous in land plants, suggesting an important role for these proteins...
December 2017: Rice
https://www.readbyqxmd.com/read/28558074/individual-expression-features-of-gpx2-nqo1-and-sqstm1-transcript-variants-induced-by-hydrogen-peroxide-treatment-in-hela-cells
#15
Anna A Belanova, Dmitry S Smirnov, Maxim S Makarenko, Mariya M Belousova, Elena V Mashkina, Anzhela A Aleksandrova, Alexander V Soldatov, Peter V Zolotukhin
Pathway activity assessment-based approaches are becoming highly influential in various fields of biology and medicine. However, these approaches mostly rely on analysis of mRNA expression, and total mRNA from a given locus is measured in the majority of cases. Notably, a significant portion of protein-coding genes produces more than one transcript. This biological fact is responsible for significant noise when changes in total mRNA transcription of a single gene are analyzed. The NFE2L2/AP-1 pathway is an attractive target for biomedical applications...
May 29, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28554003/opioids-and-opioid-receptors-orchestrate-wound-repair
#16
Ying Wang, Mihir Gupta, Tasneem Poonawala, Mariya Farooqui, Yunfang Li, Fei Peng, Sheldon Rao, Michael Ansonoff, John E Pintar, Kalpna Gupta
We have previously shown that topical opioids including morphine and its congeners promote healing of full thickness ischemic wounds in rats. We examined the contribution of mu opioid receptor (MOPr)-mediated healing of full thickness ischemic wounds using MOPr and delta or kappa opioid receptor knockout (KO) mice. Wound closure in the early (day 5) as well as later phases was delayed in topical morphine or PBS-treated MOPr-KO mice compared with reciprocal treatments of wounds in wild-type (WT) mice. MOPr expression was significantly upregulated at 30 min in the wound margins and colocalized with wound margins and vasculature in the epidermal and dermal layers of the skin...
May 18, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28532761/snapshotdx-quiz-june-2017
#17
Janelle Pavlis, Mariya Miteva
No abstract text is available yet for this article.
June 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28521172/hetarylcoumarins-synthesis-and-biological-evaluation-as-potent-%C3%AE-glucosidase-inhibitors
#18
Faryal Chaudhry, Shahnaz Choudhry, Rahila Huma, Muhammad Ashraf, Mariya Al-Rashida, Rubina Munir, Ramsha Sohail, Bakhat Jahan, Munawar Ali Munawar, Misbahul Ain Khan
In search of better α-glucosidase inhibitors, a series of novel hetarylcoumarins (3a-3j) were designed and synthesized through a facile multicomponent route where p-toluenesulfonic acid (PTSA) was explored as an efficient catalyst. These new scaffolds were further evaluated for their α-glucosidase inhibition potentials. All the derivatives exhibited good to excellent results which were comparable or even better than of standard drug acarbose. Of these compounds, a dihalogenated compound 3f was found to be the most effective one with IC50: 2...
May 10, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28520210/biases-in-the-reporting-of-hcc-tumor-sizes-on-the-liver-transplant-waiting-list
#19
Mariya L Samoylova, Mark J Nigrini, Jennifer L Dodge, John P Roberts
We investigate the possibility that patients with hepatocellular carcinoma (HCC) listed for liver transplant with tumors just outside Stage T2 size criteria may be inaccurately reported as just meeting the tumor size criteria for transplant. The UNOS/STAR database identified 12,958 patients listed for liver transplants with HCC exception points from 2006-2013, 9,168 of whom were listed with one tumor. A logistic power peak function was fitted to the single-tumor size histogram, with the fitted values representing unbiased expected values...
May 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28494764/possible-benefits-of-tomato-juice-consumption-a-pilot-study-on-irradiated-human-lymphocytes-from-healthy-donors
#20
Ayumi Nakamura, Chieko Itaki, Ayako Saito, Toko Yonezawa, Koichi Aizawa, Ayumi Hirai, Hiroyuki Suganuma, Tomisato Miura, Yasushi Mariya, Siamak Haghdoost
BACKGROUND: Reactive oxygen species (ROS) mediate much of the DNA damage caused by ionizing radiation. Among carotenoids, lycopene and β-carotene, present in tomato juice, are known to be strong radical scavengers. The aim of the study was to investigate the effect of tomato juice intake on the levels of DNA damage and oxidative stress in human whole blood induced by in vitro exposure to X-rays. METHODS: Ten healthy adults were asked to drink 190 g of tomato juice, containing 17 mg lycopene and 0...
May 12, 2017: Nutrition Journal
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