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https://www.readbyqxmd.com/read/29667698/chronic-stress-social-isolation-and-perceived-loneliness-in-dementia-caregivers
#1
Mariya Kovaleva, Sydney Spangler, Carolyn Clevenger, Kenneth Hepburn
Caregivers of individuals with dementia are at risk for chronic stress and social isolation. These exogenous factors may lead to perceived stress and perceived loneliness-psychosocial endogenous (subjective) elements of caregiving experience. Chronic stress and perceived loneliness may disrupt neuroendocrine and neuroimmunological regulation, creating low-grade systemic inflammation, promoting proinflammatory gene expression, and expediting cellular aging (endogenous physiological factors). These disturbances may enhance caregivers' risk for chronic conditions of inflammatory pathogenesis...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29658530/the-comparative-study-of-influence-of-lactic-and-glycolic-acids-copolymers-type-on-properties-of-daunorubicin-loaded-nanoparticles-and-drug-release
#2
Elena Nikolskaya, Mariya Sokol, Mariya Faustova, Olga Zhunina, Murad Mollaev, Nikita Yabbarov, Oksana Tereshchenko, Roman Popov, Eugen Severin
PURPOSE: The aim of this study was to compare the physico-chemical and biological properties of polymeric nanoparticles obtained from poly(DL-lactide-co-glycolide) (PLGA) with different ratios of monomers loaded with daunorubicin (DNR). METHODS: DNR-loaded nanoparticles (NPs) were prepared with use of modified simultaneous double-emulsion solvent evaporation/diffusion technique. NPs were characterized using dynamic light scattering, atomic force microscopy, transmission electron microscopy, scanning electron microscopy, and differential scanning calorimetry and Fourier transform infrared spectroscopy...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29649696/cholecystitis-secondary-to-gallbladder-torsion-a-rare-case-report
#3
Jason Cui, Mariya Abdullah, Iman Awan, Daniel Mehanna
INTRODUCTION: Gallbladder torsion is a rare condition of increasing prevalence in recent years. It is often difficult to diagnose pre-operatively and delayed intervention can lead to significant complications. PRESENTATION OF CASE: We present a case of an 81 year old lady who presented with symptoms of cholecystitis for 24 h with no evidence of cholelithiasis on imaging. She deteriorated within 24 h of admission despite intravenous antibiotics; Emergency laparoscopy was performed which showed the gallbladder malrotated 180 ° with features of necrosis...
April 3, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29649633/circulating-wnt-inhibitory-factor-1-levels-are-associated-with-development-of-cardiovascular-disease
#4
Claudia Ress, Mariya Paulweber, Georg Goebel, Karin Willeit, Kerstin Rufinatscha, Anna Strobl, Karin Salzmann, Ludmilla Kedenko, Alexander Tschoner, Gabriele Staudacher, Bernhard Iglseder, Herbert Tilg, Bernhard Paulweber, Susanne Kaser
BACKGROUND AND AIMS: Wnt signaling is involved in atherosclerotic plaque formation directly and indirectly by modulating cardiovascular risk factors. We investigated whether circulating concentrations of Wnt inhibitors are associated with cardiovascular events in subjects with intermediate cardiovascular risk. METHODS: 904 non-diabetic subjects participating in the SAPHIR study were assessed. In the SAPHIR study, middle-aged women without overt atherosclerotic disease at study entry were followed up for 10 years...
March 29, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29616033/keratins-regulate-p38mapk-dependent-desmoglein-binding-properties-in-pemphigus
#5
Franziska Vielmuth, Elias Walter, Michael Fuchs, Mariya Y Radeva, Fanny Buechau, Thomas M Magin, Volker Spindler, Jens Waschke
Keratins are crucial for the anchorage of desmosomes. Severe alterations of keratin organization and detachment of filaments from the desmosomal plaque occur in the autoimmune dermatoses pemphigus vulgaris and pemphigus foliaceus (PF), which are mainly caused by autoantibodies against desmoglein (Dsg) 1 and 3. Keratin alterations are a structural hallmark in pemphigus pathogenesis and correlate with loss of intercellular adhesion. However, the significance for autoantibody-induced loss of intercellular adhesion is largely unknown...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29596439/expression-of-progenitor-markers-is-associated-with-the-functionality-of-a-bioartificial-adrenal-cortex
#6
Mariya Balyura, Evgeny Gelfgat, Charlotte Steenblock, Andreas Androutsellis-Theotokis, Gerard Ruiz-Babot, Leonardo Guasti, Martin Werdermann, Barbara Ludwig, Tobias Bornstein, Andrew V Schally, Ana Brennand, Stefan R Bornstein
Encapsulation of primary bovine adrenocortical cells in alginate is an efficacious model of a bioartificial adrenal cortex. Such a bioartificial adrenal cortex can be used for the restoration of lost adrenal function in vivo as well as for in vitro modeling of the adrenal microenvironment and for investigation of cell-cell interactions in the adrenals. The aim of this work was the optimization of a bioartificial adrenal cortex, that is the generation of a highly productive, self-regenerating, long-term functioning and immune tolerant bioartificial organ...
2018: PloS One
https://www.readbyqxmd.com/read/29593240/preparation-of-zr-mo-w-2-o-8-with-a-larger-negative-thermal-expansion-by-controlling-the-thermal-decomposition-of-zr-mo-w-2-oh-cl-2-%C3%A2-2h-2-o
#7
Mariya Yu Petrushina, Elena S Dedova, Eugeny Yu Filatov, Pavel E Plyusnin, Sergei V Korenev, Sergei N Kulkov, Elizaveta A Derevyannikova, Marat R Sharafutdinov, Alexander I Gubanov
Solid solutions of Zr(Mo,W)2 O7 (OH,Cl)2 ∙2H2 O with a preset ratio of components were prepared by a hydrothermal method. The chemical composition of the solutions was determined by energy dispersive X-ray spectroscopy (EDX). For all the samples of ZrMox W2-x O7 (OH,Cl)2 ∙2H2 O (x = 0.0, 0.2, 0.4, 0.6, 0.8, 1.0, 1.2, 1.4, 1.6, 1.8, and 2.0), TGA and in situ powder X-ray diffraction (PXRD) studies (300-1100 K) were conducted. For each case, the boundaries of the transformations were determined: Zr(Mo,W)2 O7 (OH,Cl)2 ∙2H2 O → orthorhombic-ZrMox W2-x O8 (425-525 K), orthorhombic-ZrMox W2-x O8  → cubic-ZrMox W2-x O8 (700-850 K), cubic-ZrMox W2-x O8  → trigonal-ZrMox W2-x O8 (800-1050 K for x > 1) and cubic-ZrMox W2-x O8  → oxides (1000-1075 K for x ≤ 1)...
March 28, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29583055/preparation-of-mesoporous-silica-microparticles-by-sol-gel-emulsion-route-for-protein-release
#8
Mariya I Vlasenkova, Ekaterina S Dolinina, Elena V Parfenyuk
Encapsulation of therapeutic proteins into particles from appropriate material can improve both stability and delivery of the drugs, and the obtained particles can serve as a platform for development of their new oral formulations. The main goal of this work was development of sol-gel/emulsion method for preparation of silica microcapsules capable of controlled release of encapsulated protein without loss of its native structure. For this purpose, the reported in literature direct sol-gel/W/O/W emulsion method of protein encapsulation was used with some modifications, because the original method did not allow to prepare silica microcapsules capable for protein release...
March 27, 2018: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29579459/snapshotdx-quiz-april-2018
#9
Audrey Beirne, Rivka C Stone, Mariya Miteva
No abstract text is available yet for this article.
April 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29578108/initiative-for-early-lung-cancer-research-on-treatment-development-of-study-design-and-pilot-implementation
#10
Raja Flores, Emanuela Taioli, David F Yankelevitz, Betsy Jane Becker, Artit Jirapatnakul, Anthony Reeves, Rebecca Schwartz, Rowena Yip, Esther Fevrier, Kathleen Tam, Benjamin Steiger, Claudia I Henschke, Raja Flores, Andrew Kaufman, Dong-Seok Lee, Daniel Nicastri, Andrea Wolf, Kenneth Rosenzweig, Jorge Gomez, Mary Beth Beasley, Maureen Zakowski, Michael Chung, David Yankelevitz, Claudia Henschke, Rita Futamura, Sydney Kantor, Carly Wallace, Faiz Bhora, Wissam Raad, Andrew Evans, Walter Choi, Zrzu Buyuk, Adie Friedman, Ronald Dreifuss, Stacey Verzosa, Mariya Yakubox, Karina Aloferdova, Patricia Stacey, Simone De Nobrega, Rita Futamura, Sydney Kantor, Carly Wallace, Ardeshir Hakami, Kathleen Tam, Carly Wallace, Harvey Pass, Berne Crawford, Jessica Donnington, Benjamin Cooper, Andre Moreirea, Audrey Sorensen, Leslie Kohman, Robert Dunton, Jason Wallen, Christopher Curtiss, Ernest Scalzetti, Linda Ellinwood, Ralph Aye, Eric Vallieres, Brian Louie, Alex Frivar, Vivek Mehta, Kristin Manning, Maria Chona, Andrew Smith, Clifford P Connery, Emilo Torres, Dan Cruzer, Bruce Gendron, Sonya Alyea, Daniel Lackaye, Lauren Studer, Raja Flores, Claudia Henschke, Emanuela Taioli, David Yankelevitz, Betsy Becker, Artit Jirapatnakul, Anthony Reeves, Rebecca Schwartz, Rowena Yip, Esther Fevrier, Kathleen Tam, Benjamin Steiger
PURPOSE: To maximize the benefits of CT screening for lung cancer, optimal treatment is for small, early lung cancers is needed. Limiting the extent of surgery spares lung tissue, preserves pulmonary function, and decreases operative time, complications, and morbidities. It also increases the likelihood of resecting future new primary lung cancers. The goal is to assess alternative treatments in a timely manner. METHODS: The focus sessions with patients and physicians separately highlighted the need to consider their perceptions...
March 22, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29575371/practical-guide-to-dynamic-pelvic-floor-mri
#11
Mariya Kobi, Milana Flusberg, Viktoriya Paroder, Victoria Chernyak
Pelvic floor dysfunction encompasses a spectrum of functional disorders that result from impairment of the ligaments, fasciae, and muscles supporting the pelvic organs. It is a prevalent disorder that carries a lifetime risk over 10% for undergoing a surgical repair. Pelvic floor weakness presents as a wide range of symptoms, including pain, pelvic pressure or bulging, urinary and fecal incontinence, constipation, and sexual dysfunction. A correct diagnosis by clinical examination alone can be challenging, particularly in cases involving multiple compartments...
March 25, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29572860/organic-iodine-supply-affects-tomato-plants-differently-than-inorganic-iodine
#12
Mariya Halka, Magdalena Klimek-Chodacka, Sylwester Smoleń, Rafal Baranski, Iwona Ledwożyw-Smoleń, Włodzimierz Sady
Iodine is a beneficial element for human but very lowly represented in our diet. Iodine-enriched vegetables could boost the iodine content in the food chain. Despite being a beneficial element for plant, little is known about the effect of different iodine forms on plant growth. This work analyses the effect of uptake of mineral (KI) and organoiodine (5-iodosalicylic acid, 5-ISA; 3,5-diiodosalicylic acid, 3,5-di-ISA; 2-iodobenzoic acid, 2-IBeA; 4-iodobenzoic acid, 4-IBeA) compounds on tomato plants at an early stage of vegetative growth...
March 23, 2018: Physiologia Plantarum
https://www.readbyqxmd.com/read/29571854/effect-of-switching-from-glatiramer-acetate-20-mg-daily-to-glatiramer-acetate-40-mg-three-times-a-week-on-gray-and-white-matter-pathology-in-subjects-with-relapsing-multiple-sclerosis-a-longitudinal-dti-study
#13
Robert Zivadinov, Niels Bergsland, Jesper Hagemeier, Eleonora Tavazzi, Deepa P Ramasamy, Jackie Durfee, Mariya Cherneva, Ellen Carl, Jillian Carl, Channa Kolb, David Hojnacki, Bianca Weinstock-Guttman
BACKGROUND: Glatiramer acetate (GA) 40 mg × 3/weekly was approved for the treatment of relapsing-remitting multiple sclerosis (RRMS). While the beneficial effect of GA 20 mg/daily in MS patients on non-conventional MRI measures has been demonstrated, the effect of GA 40 mg × 3/weekly at the microstructural tissue level has yet to be explored. OBJECTIVE: To investigate the effect of switching from GA 20 mg/daily to GA 40 mg × 3/weekly on the evolution of microstructural changes in the thalamus and normal appearing white matter (NAWM), using diffusion tensor imaging (DTI)...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29570223/an-investigation-of-the-monoamine-oxidase-inhibition-properties-of-pyrrolo-3-4-f-indole-5-7-dione-and-indole-5-6-dicarbonitrile-derivatives
#14
Zhanna V Chirkova, Mariya V Kabanova, Sergey I Filimonov, Igor G Abramov, Anél Petzer, Idalet Engelbrecht, Jacobus P Petzer, Kyrill Yu Suponitsky, Alexander V Veselovsky
Hit, Lead & Candidate Discovery In recent studies, we have shown that pyrrolo[3,4-f]indole-5,7-dione and indole-5,6-dicarbonitrile derivatives act as good potency in vitro inhibitors of the monoamine oxidase (MAO) enzymes. To expand on these series and to further derive structure-activity relationships (SARs) for MAO inhibition, in the present study we synthesized additional homologs and related analogs of these chemical classes. Analyzes of the MAO inhibition properties of the synthesized compounds show that among the pyrrolo[3,4-f]indole-5,7-dione derivatives good potency MAO inhibitors exist as exemplified by 10, which possesses IC50 values for the inhibition of MAO-A and MAO-B of 0...
March 23, 2018: Drug Development Research
https://www.readbyqxmd.com/read/29559908/allogenic-adipose-derived-stem-cells-transplantation-improved-sciatic-nerve-regeneration-in-rats-autologous-nerve-graft-model
#15
Ruslan Masgutov, Galina Masgutova, Liliya Mukhametova, Ekaterina Garanina, Svetlana S Arkhipova, Elena Zakirova, Yana O Mukhamedshina, Zhuravleva Margarita, Zarema Gilazieva, Valeriia Syromiatnikova, Adelya Mullakhmetova, Gulnaz Kadyrova, Mariya Nigmetzyanova, Sergeev Mikhail, Pankov Igor, Ramil Yagudin, Albert Rizvanov
We examined the effect of transplantation of allogenic adipose-derived stem cells (ADSCs) with properties of mesenchymal stem cells (MSCs) on posttraumatic sciatic nerve regeneration in rats. We suggested an approach to rat sciatic nerve reconstruction using the nerve from the other leg as a graft. The comparison was that of a critical 10 mm nerve defect repaired by means of autologous nerve grafting versus an identical lesion on the contralateral side. In this experimental model, the same animal acts simultaneously as a test model, and control...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29556491/an-overview-of-the-reimbursement-decision-making-processes-in-bulgaria-as-a-reference-country-for-the-middle-income-european-countries
#16
Maria Kamusheva, Mariya Vassileva, Alexandra Savova, Manoela Manova, Guenka Petrova
Background: Policy makers face a lot of challenges in the process of drug reimbursement decision-making, especially in the context of entering the market of more and more innovative medicinal products (MPs). The aim of the current study is to make an overview of the reimbursement system development and to evaluate the access of innovative medicines, which have entered the EU-market in the period 2015-2017, in Bulgaria as reference example for middle-income European country. Methods: A literature and a legislative systematic review regarding the Bulgarian reimbursement system as well as a defining the number of available innovative reimbursed MPs in 2017 in Bulgaria was made...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29551506/genome-wide-association-study-in-ethnic-russians-suggests-an-association-of-the-mhc-class-iii-genomic-region-with-the-risk-of-primary-varicose-veins
#17
Alexandra Shadrina, Yakov Tsepilov, Ekaterina Sokolova, Mariya Smetanina, Elena Voronina, Eugene Pakhomov, Kseniya Sevost'ianova, Andrey Shevela, Evgeny Ilyukhin, Evgeny Seliverstov, Igor Zolotukhin, Maxim Filipenko
Heredity is a well-known risk factor for varicose veins, but genetic basis of this condition remains poorly studied. Our aim was to conduct a large-scale genetic association study for primary varicose veins (PVVs) in the population of ethnic Russians. An initial scan using Illumina HumanExome-12 v1.0 BeadChip was performed for 273 patients with PVVs and 250 controls without a history of chronic venous disease and other venous disorders. After quality control and removal of monomorphic markers, 25,424 common and 48,232 rare variants were included in the analysis...
March 15, 2018: Gene
https://www.readbyqxmd.com/read/29546406/characteristics-of-combat-associated-small-bowel-injuries
#18
Mariya E Skube, Quinn Mallery, Elizabeth Lusczek, Joel Elterman, Mary A Spott, Greg J Beilman
Introduction: Although there are multiple studies regarding the management and outcomes of colonic injuries incurred in combat, the literature is limited with regard to small bowel injuries. This study seeks to provide the largest reported review of the characteristics of combat-associated small bowel injuries. Materials and Methods: The Department of Defense Trauma Registry was queried for U.S. Armed Forces members who sustained hollow viscus injuries in the years 2007-2012 during Operations Enduring Freedom, Iraqi Freedom, and New Dawn...
March 13, 2018: Military Medicine
https://www.readbyqxmd.com/read/29544342/tele-savvy-an-online-program-for-dementia-caregivers
#19
Patricia C Griffiths, Mariya Kovaleva, Melinda Higgins, Ashley H Langston, Kenneth Hepburn
INTRODUCTION: This study examined the feasibility and efficacy of Tele-Savvy, an online version of the Savvy Caregiver Program, a psychoeducation program for caregivers caring for a person with dementia. METHODS: A convenience sample of 22 caregivers from the Atlanta VA and 42 caregivers from 14 different states enrolled in Tele-Savvy. Pre- and post-program evaluations assessed caregiver burden, caregiver competency, and frequency of behavioral and psychological symptoms of dementia (BPSD)...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29540156/assessing-microscope-image-focus-quality-with-deep-learning
#20
Samuel J Yang, Marc Berndl, D Michael Ando, Mariya Barch, Arunachalam Narayanaswamy, Eric Christiansen, Stephan Hoyer, Chris Roat, Jane Hung, Curtis T Rueden, Asim Shankar, Steven Finkbeiner, Philip Nelson
BACKGROUND: Large image datasets acquired on automated microscopes typically have some fraction of low quality, out-of-focus images, despite the use of hardware autofocus systems. Identification of these images using automated image analysis with high accuracy is important for obtaining a clean, unbiased image dataset. Complicating this task is the fact that image focus quality is only well-defined in foreground regions of images, and as a result, most previous approaches only enable a computation of the relative difference in quality between two or more images, rather than an absolute measure of quality...
March 15, 2018: BMC Bioinformatics
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