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JOURNAL ARTICLE
Ivan V Chernikov, Irina K Bachkova, Aleksandra V Sen'kova, Mariya I Meschaninova, Innokenty A Savin, Valentin V Vlassov, Marina A Zenkova, Elena L Chernolovskaya
Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target genes through RNA interference. Current clinical applications of siRNA have been primarily limited to liver diseases, while achievements in delivery methods are expanding their applications to various organs, including the lungs. Cholesterol-conjugated siRNA emerges as a promising delivery approach due to its low toxicity and high efficiency. This study focuses on developing a cholesterol-conjugated anti- Il6 siRNA and the evaluation of its potency for the potential treatment of inflammatory diseases using the example of acute lung injury (ALI)...
April 30, 2024: Cells
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JOURNAL ARTICLE
Gabriela Lima de Melo Ghisi, Mayara Moura Alves da Cruz, Luiz Carlos Marques Vanderlei, Xia Liu, Zhimin Xu, Mariya Prakash Jiandani, Lucky Cuenza, Evangelia Kouidi, Francesco Giallauria, Jibril Mohammed, Lela Maskhulia, Patricia Fernandes Trevizan, Ladislav Batalik, Danielle Gomes Pereira, Nidal Tourkmani, Ivana Burazor, Elio Venturini, Gerlene Grudka Lira, Manuella Bennaton Cardoso Vieira Rehfeld, Victor Ribeiro Neves, Geovana de Jesus Borges, Won-Seok Kim, Seungwoo Cha, Ling Zhang, Sherry L Grace
AIMS: Tailored education is recommended for cardiac patients, yet little is known about information needs in areas of the world where it is most needed. This study aims to assess (i) the measurement properties of the Information Needs in Cardiac Rehabilitation short version (INCR-S) scale and (ii) patient's information needs globally. METHODS AND RESULTS: In this cross-sectional study, English, simplified Chinese, Portuguese, or Korean versions of the INCR-S were administered to in- or out-patients via Qualtrics (January 2022-November 2023)...
May 9, 2024: European Journal of Preventive Cardiology
#3
JOURNAL ARTICLE
Ihor Krasivskyi, Borko Ivanov, Zakaria Msallati, Clara Großmann, Stephen Gerfer, Mariya Mihaylova, Kaveh Eghbalzadeh, Christian Origel Romero, Ilija Djordjevic, Thorsten Wahlers, Farhad Bakhtiary, Anton Sabashnikov
INTRODUCTION: Diabetes mellitus (DM) is associated with concomitant comorbidities, such as atherosclerosis and cardiovascular disease. Coronary artery bypass grafting (CABG) surgery is the optimal therapy in diabetic patients with triple vessel disease. DM is also known to be a relevant risk factor for higher morbidity and mortality in patients who underwent elective CABG procedures. Data regarding outcomes in diabetic patients in acute coronary syndrome (ACS) is heterogeneous. This study aimed to investigate the impact of DM on short-term outcomes in patients who underwent CABG surgery in ACS...
May 8, 2024: Perfusion
#4
JOURNAL ARTICLE
Solène Lefebvre du Grosriez, Sandrine Isoard-Gautheur, Mariya Yukhymenko-Lescroart, Philippe Sarrazin
BACKGROUND: Effectively managing their athletic and academic projects is a major challenge for student-athletes. The salience of the identity they develop in each of these contexts can affect their well-being and is therefore an important variable to consider. Examining these mechanisms in countries and student-athlete support systems other than the United States is also important. AIM: This study aims to both translate and evaluate the psychometric properties of a French version of the Academic and Athletic Identity Scale, the AAIS-FR, and to examine the additive and interactive relationships of the two identities with sport burnout and engagement...
2024: PloS One
#5
JOURNAL ARTICLE
Sven M Piepenburg, Mariya Maslarska, Klaus Kaier, Constantin von Zur Mühlen, Dirk Westermann, Christoph Hehrlein
BACKGROUND: The COVID-19 pandemic developed its full destructive capacity in 2020. This retrospective study aimed to examine the effects of COVID-19 on the mortality and the clinical characteristics in PAD patients with COVID-19 compared to PAD patients without COVID-19. METHODS AND RESULTS: Data derived from a German nationwide register of the year 2020 which encompassed all hospitalized patients with PAD ( n = 173.075); N = 2553 also suffered from a COVID-19 infection and had significantly higher mortality rates of 11...
May 6, 2024: Angiology
#6
Michel Chedid El Helou, Mariya Geube, Shinya Unai, Nicholas Smedira, Brian Griffin, Patrick Collier
A 38-year-old male with a history of myxomatous mitral valve disease post-repair presented with recurrent dyspnea during exertion. Initial evaluation showed mild systolic anterior motion and mitral regurgitation, but medical management was unsuccessful. The patient underwent reoperation; intraoperative transesophageal echocardiogram with provocation unmasked severe systolic anterior motion and torrential mitral regurgitation.
May 1, 2024: JACC. Case reports
#7
Laura Torrens, Sarah Moody, Ana Carolina de Carvalho, Mariya Kazachkova, Behnoush Abedi-Ardekani, Saamin Cheema, Sergey Senkin, Thomas Cattiaux, Ricardo Cortez Cardoso Penha, Joshua R Atkins, Valérie Gaborieau, Priscilia Chopard, Christine Carreira, Ammal Abbasi, Erik N Bergstrom, Raviteja Vangara, Jingwei Wang, Stephen Fitzgerald, Calli Latimer, Marcos Diaz-Gay, David Jones, Jon Teague, Felipe Ribeiro Pinto, Luiz Paulo Kowalski, Jerry Polesel, Fabiola Giudici, José Carlos de Oliveira, Pagona Lagiou, Areti Lagiou, Marta Vilensky, Dana Mates, Ioan N Mates, Lidia Mrb Arantes, Rui Reis, Jose Roberto V Podesta, Sandra V von Zeidler, Ivana Holcatova, Maria Paula Curado, Cristina Canova, Elenora Fabianova, Paula A Rodríguez-Urrego, Laura Humphreys, Ludmil B Alexandrov, Paul Brennan, Michael R Stratton, Sandra Perdomo
Tobacco smoke, alone or combined with alcohol, is the predominant cause of head and neck cancer (HNC). Here, we further explore how tobacco exposure contributes to cancer development by mutational signature analysis of 265 whole-genome sequenced HNC from eight countries. Six tobacco-associated mutational signatures were detected, including some not previously reported. Differences in HNC incidence between countries corresponded with differences in mutation burdens of tobacco-associated signatures, consistent with the dominant role of tobacco in HNC causation...
April 17, 2024: medRxiv
#8
JOURNAL ARTICLE
Jun-Ichi Hanatani, Koh Kitagawa, Fumimasa Tomooka, Shohei Asada, Akira Mitoro, Yukihisa Fujinaga, Norihisa Nishimura, Shinya Sato, Akihiko Shibamoto, Yuki Fujimoto, Takahiro Kubo, Satoshi Iwai, Yuki Tsuji, Tadashi Namisaki, Takemi Akahane, Kosuke Kaji, Misako Tanaka, Aritoshi Koizumi, Nobuyuki Yorioka, Takuya Matsuda, Hiroyuki Masuda, Masayoshi Takami, Mayuko Kikuchi, Mariya Kawanishi, Kazutaka Ohoka, Daisuke Watanabe, Akane Kawasaki, Hitoshi Yoshiji
OBJECTIVES: This study aimed to determine the impact of the coronavirus disease 2019 (COVID-19) pandemic on the treatment of acute cholangitis caused by choledocholithiasis. METHODS: The Japanese government declared a state of emergency in April 2020 due to the COVID-19 pandemic. We retrospectively reviewed the medical records of 309 patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) for acute cholangitis caused by choledocholithiasis between April 2017 and December 2022...
April 2025:
#9
JOURNAL ARTICLE
Sergey Senkin, Sarah Moody, Marcos Díaz-Gay, Behnoush Abedi-Ardekani, Thomas Cattiaux, Aida Ferreiro-Iglesias, Jingwei Wang, Stephen Fitzgerald, Mariya Kazachkova, Raviteja Vangara, Anh Phuong Le, Erik N Bergstrom, Azhar Khandekar, Burçak Otlu, Saamin Cheema, Calli Latimer, Emily Thomas, Joshua Ronald Atkins, Karl Smith-Byrne, Ricardo Cortez Cardoso Penha, Christine Carreira, Priscilia Chopard, Valérie Gaborieau, Pekka Keski-Rahkonen, David Jones, Jon W Teague, Sophie Ferlicot, Mojgan Asgari, Surasak Sangkhathat, Worapat Attawettayanon, Beata Świątkowska, Sonata Jarmalaite, Rasa Sabaliauskaite, Tatsuhiro Shibata, Akihiko Fukagawa, Dana Mates, Viorel Jinga, Stefan Rascu, Mirjana Mijuskovic, Slavisa Savic, Sasa Milosavljevic, John M S Bartlett, Monique Albert, Larry Phouthavongsy, Patricia Ashton-Prolla, Mariana R Botton, Brasil Silva Neto, Stephania Martins Bezerra, Maria Paula Curado, Stênio de Cássio Zequi, Rui Manuel Reis, Eliney Ferreira Faria, Nei Soares de Menezes, Renata Spagnoli Ferrari, Rosamonde E Banks, Naveen S Vasudev, David Zaridze, Anush Mukeriya, Oxana Shangina, Vsevolod Matveev, Lenka Foretova, Marie Navratilova, Ivana Holcatova, Anna Hornakova, Vladimir Janout, Mark P Purdue, Nathaniel Rothman, Stephen J Chanock, Per Magne Ueland, Mattias Johansson, James McKay, Ghislaine Scelo, Estelle Chanudet, Laura Humphreys, Ana Carolina de Carvalho, Sandra Perdomo, Ludmil B Alexandrov, Michael R Stratton, Paul Brennan
International differences in the incidence of many cancer types indicate the existence of carcinogen exposures that have not yet been identified by conventional epidemiology make a substantial contribution to cancer burden1 . In clear cell renal cell carcinoma, obesity, hypertension and tobacco smoking are risk factors, but they do not explain the geographical variation in its incidence2 . Underlying causes can be inferred by sequencing the genomes of cancers from populations with different incidence rates and detecting differences in patterns of somatic mutations...
May 1, 2024: Nature
#10
JOURNAL ARTICLE
Krasimir Kraev, Bozhidar Hristov, Petar Uchikov, Mariya Kraeva, Mariela Geneva-Popova, Stanislava Popova, Yordanka Basheva-Kraeva, Nina S Stoyanova, Vesela Mitkova-Hristova
This study aimed to construct prognostic mathematical models utilizing multifactorial regression analysis to assess the risk of developing drug-induced neutralizing antibodies in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis treated with tumor necrosis factor alpha blockers.
April 30, 2024: Folia Medica
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JOURNAL ARTICLE
Zhanna M Sizova, Valeria L Zakharova, Natalya N Shindryaeva, Natalia I Lapidus, Mariya V Melnik, Evgenia V Shikh, Ludmila Y Grebenshchikova, Alexandra V Beloborodova, Ivan P Polovikov
Atrial fibrillation (AF) is the most common heart rhythm disorder in clinical practice. It worsens the quality of life of patients, leads to an increase in the mortality rate because of its association with a high risk of thromboembolic complications. The current pandemic of a new coronavirus infection, which began in March 2020, was marked by an increase in cardiovascular diseases, including an increase in the number of patients with AF. That is why it is extremely relevant to find answers to questions about the association and mutual influence of AF and coronavirus infection to reduce the risk of vascular complications...
2024: Frontiers in Cardiovascular Medicine
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JOURNAL ARTICLE
Astrid Marchal, Elizabeth T Cirulli, Iva Neveux, Evangelos Bellos, Ryan S Thwaites, Kelly M Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G Tangye, András N Spaan, Justin B Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Clifton L Dalgard, Shen-Ying Zhang, Qian Zhang, Christopher Chiu, Jacques Fellay, Joseph J Grzymski, Vanessa Sancho-Shimizu, Laurent Abel, Jean-Laurent Casanova, Aurélie Cobat, Alexandre Bolze
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B*15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B*15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the US (191 asymptomatic vs...
April 26, 2024: HGG advances
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JOURNAL ARTICLE
Emily J Tetzlaff, Farah Mourad, Nicholas Goulet, Melissa Gorman, Rachel Siblock, Sean A Kidd, Mariya Bezgrebelna, Glen P Kenny
Among the most vulnerable to the health-harming effects of heat are people experiencing homelessness. However, during the 2021 Heat Dome, the deadliest extreme heat event (EHE) recorded in Canada to date, people experiencing homelessness represented the smallest proportion of decedents (n = 3, 0.5%)-despite the impacted region (British Columbia) having some of the highest rates of homelessness in the country. Thus, we sought to explore the 2021 Heat Dome as a media-based case study to identify potential actions or targeted strategies that were initiated by community support agencies, individuals and groups, and communicated in the news during this EHE that may have aided in the protection of this group or helped minimize the mortality impacts...
March 27, 2024: International Journal of Environmental Research and Public Health
#14
JOURNAL ARTICLE
Marah Baddour, Ruth Garcia-Campà, Pablo Reyes, Dagmar R D'hooge, Ludwig Cardon, Mariya Edeleva
Continuous carbon fiber (cCF)-based 3D-printed polymer composites are known for their excellent flexural properties; however, the optimization of the overall process is still desired, depending on the material types involved. Here, the improved manufacturing of cCF-based composites is reported, considering virgin polyamide (PA) and postindustrial waste polypropylene (PP), and the parameters affecting the material properties are evaluated. Firstly, the prepregnation technique was optimized to manufacture cCF polymer filaments with various fiber-to-polymer ratios...
April 12, 2024: Materials
#15
REVIEW
Manish Mair, Hitesh Singhavi, Ameya Pai, Mariya Khan, Peter Conboy, Oladejo Olaleye, Rami Salha, Phil Ameerally, Ram Vaidhyanath, Pankaj Chaturvedi
BACKGROUND: Extracapsular spread (ECS) is the extension of cancer cells beyond the lymph node capsule and is a significant prognostic factor in head and neck cancers. This meta-analysis compared the diagnostic accuracy of CT, MRI, PET, and USG in detecting ECS in head and neck cancers. METHODOLOGY: The authors conducted a systematic review and meta-analysis of studies that compared the diagnostic accuracy of CT, MRI, PET, and USG in detecting ECS in head and neck cancers...
April 10, 2024: Cancers
#16
REVIEW
Anatoly A Sorokin, Stanislav I Pekov, Denis S Zavorotnyuk, Mariya M Shamraeva, Denis S Bormotov, Igor A Popov
This article provides a comprehensive overview of the applications of methods of machine learning (ML) and artificial intelligence (AI) in ambient ionization mass spectrometry (AIMS). AIMS has emerged as a powerful analytical tool in recent years, allowing for rapid and sensitive analysis of various samples without the need for extensive sample preparation. The integration of ML/AI algorithms with AIMS has further expanded its capabilities, enabling enhanced data analysis. This review discusses ML/AI algorithms applicable to the AIMS data and highlights the key advancements and potential benefits of utilizing ML/AI in the field of mass spectrometry, with a focus on the AIMS community...
April 26, 2024: Mass Spectrometry Reviews
#17
JOURNAL ARTICLE
Vladimir N Lebedev, Mariya I Kharovskaya, Bogdan I Lazoryak, Anastasiya O Solovieva, Inna V Fadeeva, Abdulkarim A Amirov, Maksim A Koliushenkov, Farid F Orudzhev, Oksana V Baryshnikova, Viktoriya G Yankova, Julietta V Rau, Dina V Deyneko
β-tricalcium phosphate (β-TCP) is a promising material in regenerative traumatology for the creation of bone implants. Previously, it was established that doping the structure with certain cations can reduce the growth of bacterial activity. Recently, much attention has been paid to co-doped β-TCP, that is explained by their ability, on the one hand, to reduce cytotoxicity for cells of the human organism, on the other hand, to achieve a successful antibacterial effect. Sr, Cu-co-doped solid solutions of the composition Ca9...
April 20, 2024: Biomimetics
#18
JOURNAL ARTICLE
Zbynek Stranak, Taras Ardan, Yaroslav Nemesh, Maria Toms, Lyes Toualbi, Richard Harbottle, Zdenka Ellederova, Lyubomyr Lytvynchuk, Goran Petrovski, Jan Motlik, Mariya Moosajee, Igor Kozak
PURPOSE: To assess the safety and feasibility of direct vitrectomy-sparing subretinal injection for gene delivery in a large animal model. METHODS: The experimental Liběchov minipigs were used for subretinal delivery of a plasmid DNA vector (pS/MAR-CMV-copGFP) with cytomegalovirus (CMV) promoter, green fluorescent protein (GFP) reporter (copGFP) and a scaffold/matrix attachment region (S/MAR) sequence. The eyes were randomized to subretinal injection of the vector following pars plana vitrectomy (control group) or a direct injection without prior vitrectomy surgery (experimental group)...
April 26, 2024: Current Eye Research
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JOURNAL ARTICLE
Ellery Frahm, Mariam Saribekyan, Satenik Mkrtchyan, Laura Furquim, Ara Avagyan, Lilit Sahakyan, Karen Azatyan, Patrick Roberts, Ricardo Fernandes, Levon Yepiskoposyan, Noel Amano, Mariya Antonosyan
The newly excavated rockshelter of Yeghegis-1 in Armenia reflects an occupation of five centuries, as attested by radiocarbon dates from ∼ 4100 to 4000 cal BCE in the lowest layer to ∼ 3600-3500 cal BCE at the top. It is a partially collapsed cave in which pastoralists, we hypothesize, wintered with their herds. The stone tool assemblage is predominantly obsidian (92.1%), despite the shelter being > 60 km on foot from the nearest sources. We use obsidian sourcing to investigate two purported trends in the Southern Caucasus during the Chalcolithic Period: (1) occupation of more varied high-altitude environments and (2) more expansive social networks...
April 25, 2024: Scientific Reports
#20
JOURNAL ARTICLE
Mariya A Yukhymenko-Lescroart, Olena Voiedilova
The aim of this study was to translate the Flourishing Scale, which is a brief 8-item measure, into Ukrainian and examine its construct validity. The Flourishing Scale has been previously validated into various languages, including Russian. While Ukrainian is a distinct language with its unique characteristics, it shares some similarities with Russian due to historical and geographical connections. These similarities encompass words with similar or related meanings, comparable sentence structures, and certain cultural references and idiomatic expressions...
June 2024: MethodsX
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