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https://www.readbyqxmd.com/read/29227474/a-proteolytic-fragment-of-histone-deacetylase-4-protects-the-heart-from-failure-by-regulating-the-hexosamine-biosynthetic-pathway
#1
Lorenz H Lehmann, Zegeye H Jebessa, Michael M Kreusser, Axel Horsch, Tao He, Mariya Kronlage, Matthias Dewenter, Viviana Sramek, Ulrike Oehl, Jutta Krebs-Haupenthal, Albert H von der Lieth, Andrea Schmidt, Qiang Sun, Julia Ritterhoff, Daniel Finke, Mirko Völkers, Andreas Jungmann, Sven W Sauer, Christian Thiel, Alexander Nickel, Michael Kohlhaas, Michaela Schäfer, Carsten Sticht, Christoph Maack, Norbert Gretz, Michael Wagner, Ali El-Armouche, Lars S Maier, Juan E Camacho Londoño, Benjamin Meder, Marc Freichel, Hermann-Josef Gröne, Patrick Most, Oliver J Müller, Stephan Herzig, Eileen E M Furlong, Hugo A Katus, Johannes Backs
The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates cardiac gene expression. Here we show that the levels of an N-terminal proteolytically derived fragment of HDAC4, termed HDAC4-NT, are lower in failing mouse hearts than in healthy control hearts. Virus-mediated transfer of the portion of the Hdac4 gene encoding HDAC4-NT into the mouse myocardium protected the heart from remodeling and failure; this was associated with decreased expression of Nr4a1, which encodes a nuclear orphan receptor, and decreased NR4A1-dependent activation of the hexosamine biosynthetic pathway (HBP)...
December 11, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29220735/regulation-of-sulfur-deprivation-induced-expression-of-the-ferredoxin-encoding-fdx5-gene-chlamydomonas-reinhardtii-in-aerobic-conditions
#2
Zhanneta Zalutskaya, Ekaterina Minaeva, Valentina Filina, Mariya Ostroukhova, Elena Ermilova
The unicellular green alga Chlamydomonas reinhardtii reacts to sulfur (S) starvation with the increased expression of numerous genes. One gene which is induced in illuminated anaerobic S-deprived cells is the ferredoxin-5 gene (FDX5). To test FDX5 transcriptional regulation in aerobic cultures, we used a real-time PCR analysis and an artificial microRNA approach. We demonstrated that FDX5 gene is controlled by S deprivation independently of anoxia-treatment. The Ser/Thr kinase SNRK2.1 is necessary for expression of FDX5 during deprivation to S...
December 2, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29200685/a-study-on-utilization-and-evaluation-of-antiemetics-in-chemotherapy-induced-nausea-and-vomiting
#3
Gayathri Baburaj, Ansha Mariya Abraham, Lija George, Vijith Shetty, Rovin M Thempalangad, K S Rajesh, K C Bharath Raj
Purpose: Chemotherapy-induced nausea and vomiting (CINV) are the major adverse effects of cancer chemotherapy. The objectives of this study are to evaluate the utilization of antiemetics in CINV and to assess the emetogenicity of chemotherapy and to investigate the incidence of acute and delayed CINV. Methods: A prospective observational study was carried out in patients undergoing chemotherapy. A suitable data collection form was designed to collect data regarding patient's demographics, cancer type, chemotherapy regimen, antiemetic prescribed, and incidence of CINV according to the standard methods utilizing morrow assessment of nausea and emesis form...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29195078/a-next-generation-connectivity-map-l1000-platform-and-the-first-1-000-000-profiles
#4
Aravind Subramanian, Rajiv Narayan, Steven M Corsello, David D Peck, Ted E Natoli, Xiaodong Lu, Joshua Gould, John F Davis, Andrew A Tubelli, Jacob K Asiedu, David L Lahr, Jodi E Hirschman, Zihan Liu, Melanie Donahue, Bina Julian, Mariya Khan, David Wadden, Ian C Smith, Daniel Lam, Arthur Liberzon, Courtney Toder, Mukta Bagul, Marek Orzechowski, Oana M Enache, Federica Piccioni, Sarah A Johnson, Nicholas J Lyons, Alice H Berger, Alykhan F Shamji, Angela N Brooks, Anita Vrcic, Corey Flynn, Jacqueline Rosains, David Y Takeda, Roger Hu, Desiree Davison, Justin Lamb, Kristin Ardlie, Larson Hogstrom, Peyton Greenside, Nathanael S Gray, Paul A Clemons, Serena Silver, Xiaoyun Wu, Wen-Ning Zhao, Willis Read-Button, Xiaohua Wu, Stephen J Haggarty, Lucienne V Ronco, Jesse S Boehm, Stuart L Schreiber, John G Doench, Joshua A Bittker, David E Root, Bang Wong, Todd R Golub
We previously piloted the concept of a Connectivity Map (CMap), whereby genes, drugs, and disease states are connected by virtue of common gene-expression signatures. Here, we report more than a 1,000-fold scale-up of the CMap as part of the NIH LINCS Consortium, made possible by a new, low-cost, high-throughput reduced representation expression profiling method that we term L1000. We show that L1000 is highly reproducible, comparable to RNA sequencing, and suitable for computational inference of the expression levels of 81% of non-measured transcripts...
November 30, 2017: Cell
https://www.readbyqxmd.com/read/29186283/intracellular-trafficking-of-transforming-growth-factor-%C3%AE-receptors
#5
Ihor Yakymovych, Mariya Yakymovych, Carl-Henrik Heldin
Transforming growth factor β (TGFβ) family members signal via heterotetrameric complexes of type I (TβRI) and type II (TβRII) dual specificity kinase receptors. The availability of the receptors on the cell surface is controlled by several mechanisms. Newly synthesized TβRI and TβRII are delivered from the Golgi apparatus to the cell surface via separate routes. On the cell surface, TGFβ receptors are distributed between different microdomains of the plasma membrane and can be internalized via clathrin- and caveolae-mediated endocytic mechanisms...
November 25, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/29179985/cardiac-cd68-and-stabilin-1-macrophages-in-wound-healing-following-myocardial-infarction-from-experiment-to-clinic
#6
Vyacheslav Ryabov, Aleksandra Gombozhapova, Yuliya Rogovskaya, Julia Kzhyshkowska, Mariya Rebenkova, Rostislav Karpov
Myocardial infarction (MI) remains the leading cause of mortality and morbidity throughout the world. Macrophages are key innate immune cells that play a significant role in transition from the inflammatory to the regenerative phase during wound healing following MI. The scavenger receptor stabilin-1 is one of the most interesting macrophage biomarkers. This receptor contributes to wound healing, angiogenesis, and tissue remodeling. We suggested a research protocol using macrophage biomarkers to study the cellular basis of cardiac remodeling and healing in patients with acute MI...
November 22, 2017: Immunobiology
https://www.readbyqxmd.com/read/29177151/blue-white-veil-as-novel-dermatoscopic-feature-in-discoid-lupus-erythematosus-in-2-african-american-patients
#7
Jessica Cervantes, Farhaan Hafeez, Mariya Miteva
Dermoscopic features of discoid lupus erythematosus (DLE) depend on the stage of the lesions: active lesions include yellow-brown dots and red dots, whereas longstanding inactive lesions show absence of follicular openings, cicatricial milky red or white patches, structureless white and brown areas, and thick arborizing vessels. Loss of pinpoint white dots, blue-gray dots in a speckled pattern, and a peripheral pigmented network have been described on dermoscopy of DLE in dark skin. We report a blue-white veil as a novel dermoscopic feature in 2 cases of biopsy-proven DLE in African-American patients...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29177141/a-case-of-circumscribed-scalp-morphea-with-perineural-lymphocytes-on-pathology
#8
David Saceda-Corralo, Aron G Nusbaum, Paolo Romanelli, Mariya Miteva
Scalp morphea presents as a scarring alopecia in en coup du sabre pattern. We report an unusual presentation of a round hairless patch of morphea on the occipital scalp present for 15 years. The scalp lesion aligned with 2 other hyperpigmented lesions of biopsy-proven morphea in the lower back. Pathology of horizontal sections from the scalp lesion showed follicular dropout, thickening of the collagen bundles, and preserved eccrine and follicular structures. Marked lymphocytic perineural infiltrate, a reported clue to the diagnosis of scalp morphea, contributed to the diagnosis...
October 2017: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29175204/cerebral-peak-alpha-frequency-predicts-individual-differences-in-pain-sensitivity
#9
Andrew J Furman, Timothy J Meeker, Jeremy C Rietschel, Sooyoung Yoo, Janusiya Muthulingam, Mariya Prokhorenko, Michael L Keaser, Ronald N Goodman, Ali Mazaheri, David A Seminowicz
The identification of neurobiological markers that predict individual predisposition to pain are not only important for development of effective pain treatments, but would also yield a more complete understanding of how pain is implemented in the brain. In the current study using electroencephalography (EEG), we investigated the relationship between the peak frequency of alpha activity over sensorimotor cortex and pain intensity during capsaicin-heat pain (C-HP), a prolonged pain model known to induce spinal central sensitization in primates...
November 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29170434/single-cell-absolute-contact-probability-detection-reveals-chromosomes-are-organized-by-multiple-low-frequency-yet-specific-interactions
#10
Diego I Cattoni, Andrés M Cardozo Gizzi, Mariya Georgieva, Marco Di Stefano, Alessandro Valeri, Delphine Chamousset, Christophe Houbron, Stephanie Déjardin, Jean-Bernard Fiche, Inma González, Jia-Ming Chang, Thomas Sexton, Marc A Marti-Renom, Frédéric Bantignies, Giacomo Cavalli, Marcelo Nollmann
At the kilo- to megabase pair scales, eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that associate to form nuclear compartments. Here, we combine high-content super-resolution microscopies with state-of-the-art DNA-labeling methods to reveal the variability in the multiscale organization of the Drosophila genome. We find that association frequencies within TADs and between TAD borders are below ~10%, independently of TAD size, epigenetic state, or cell type...
November 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/29169466/snapshotdx-quiz-december-2017
#11
Shailee Patel, Mariya Miteva
No abstract text is available yet for this article.
December 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29157333/a-cohort-mortality-study-among-soviet-and-russian-cosmonauts-1961-2014
#12
Igor B Ushakov, Yuri I Voronkov, Igor V Bukhtiyarov, Galina I Tikhonova, Tatyana Yu Gorchakova, Mariya S Bryleva
INTRODUCTION: Over 500 people from different countries have been to space since the first manned spaceflight in 1961. Factors of space and spaceflights might cause functional and somatic disorders, leading to increased mortality. Our research goal was to assess cause-specific risk of death among Soviet and Russian cosmonauts who had at least one spaceflight. METHODS: The epidemiological cohort study included 115 male cosmonauts. The observation period was 54 yr (January 1, 1961-December 31, 2014) and 2707 person-years of follow-up were obtained...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29129025/assessment-of-circulating-wnt1-inducible-signalling-pathway-protein-1-wisp-1-ccn4-as-a-novel-biomarker-of-obesity
#13
Christopher Tacke, Krasimira Aleksandrova, Miriam Rehfeldt, Veronica Murahovschi, Mariya Markova, Margrit Kemper, Silke Hornemann, Ulrike Kaiser, Caroline Honig, Christiana Gerbracht, Stefan Kabisch, Tina Hörbelt, D Margriet Ouwens, Martin O Weickert, Heiner Boeing, Andreas F H Pfeiffer, Olga Pivovarova, Natalia Rudovich
WNT1 inducible signaling pathway protein 1 (WISP-1/CCN4) is a novel adipokine, which is upregulated in obesity, and induces a pro-inflammatory response in macrophages in-vitro. Preclinical observations suggested WISP-1/CCN4 as a potential candidate for novel obesity therapy targeting adipose tissue inflammation. Whether circulating levels of WISP-1/CCN4 in humans are altered in obesity and/or type 2 diabetes (T2DM) and in the postprandial state, however, is unknown. This study assessed circulating WISP-1/CCN4 levels in a) paired liquid meal tests and hyperinsulinemic- euglycemic clamps (cohort I, n = 26), b) healthy individuals (cohort II, n = 207) and c) individuals with different stages of obesity and glucose tolerance (cohort III, n = 253)...
November 11, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29128347/routine-use-of-pico-dressings-may-reduce-overall-groin-wound-complication-rates-following-peripheral-vascular-surgery
#14
Christina A Fleming, Mariya Kuteva, Karen O'Hanlon, Gavin O'Brien, Gerald McGreal
BACKGROUND: Approximately 19% of morbidity in peripheral vascular surgery is attributable to wound complications, which can result in delayed healing, but also arterial or graft infection leading to limb loss and even mortality in extreme cases. AIM: To determine whether groin wound complications were reduced following the routine introduction of PICO negative pressure wound therapy dressings (Smith & Nephew, Hull, England) in patients who had peripheral vascular surgery...
November 8, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29127915/sigmoid-perforation-caused-by-dentures-a-rare-case-report
#15
Mariya Abdullah, Jason Cui, Rasika Hendaheva
Rare case of an elderly male presenting to the emergency department with an acute abdomen few days post accidental ingestion of his dentures. A detailed history along with a CT abdomen showed perforation in the sigmoid colon adjacent to the site of the swallowed denture.
November 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29104659/estimation-of-effective-doses-in-pediatric-x-ray-computed-tomography-examination
#16
Hideki Obara, Midori Takahashi, Kazuya Kudou, Yasushi Mariya, Yoshihiro Takai, Ikuo Kashiwakura
X-ray computed tomography (CT) images are used for diagnostic and therapeutic purposes in various medical disciplines. In Japan, the number of facilities that own diagnostic CT equipment, the number of CT examinations and the number of CT scanners increased by ~1.4-fold between 2005 and 2011. CT operators (medical radiological technologists, medical physicists and physicians) must understand the effective doses for examinations at their own institutions and carefully approach each examination. In addition, the patients undergoing the examination (as well as his/her family) must understand the effective dose of each examination in the context of the cumulative dose...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29096084/nitric-oxide-upregulates-expression-of-alternative-oxidase-1-in-chlamydomonas-reinhardtii
#17
Zhanneta Zalutskaya, Mariya Ostroukhova, Valentina Filina, Elena Ermilova
The mitochondrial respiratory chain in plants, many fungi and some protists consists of the ATP-coupling cyanide-sensitive cytochrome pathway and the cyanide-resistant alternative respiratory pathway. The alternative pathway is mediated by alternative oxidase (AOX). In unicellular algae, AOXs are monomeric fungi-type proteins. Studies performed in the model plant Chlamydomonas reinhardtii showed that a range of stress factors lead to induction of its AOX1. However, signaling molecules that trigger upregulation of AOX1 have not yet been identified...
October 28, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29079795/comprehensive-single-cell-transcriptome-analysis-reveals-heterogeneity-in-endometrioid-adenocarcinoma-tissues
#18
Shinichi Hashimoto, Yuta Tabuchi, Hideaki Yurino, Yoshihiko Hirohashi, Shungo Deshimaru, Takuya Asano, Tasuku Mariya, Kenshiro Oshima, Yuzuru Takamura, Yoshiaki Ukita, Akio Ametani, Naoto Kondo, Norikazu Monma, Tadayuki Takeda, Sadahiko Misu, Toshitugu Okayama, Kazuho Ikeo, Tsuyoshi Saito, Shuich Kaneko, Yutaka Suzuki, Masahira Hattori, Kouji Matsushima, Toshihiko Torigoe
Single cell transcriptome analysis of a cancer tissue can provide objective assessment of subtype population or the activation of each of various microenvironment component cells. In this study, we applied our newly developed technique of single cell analysis to the myometrial infiltration side (M-side) and the endometrial side (E-side) of a human endometrioid adenocarcinoma with squamous differentiation tissues. We also analyzed spherogenic cultures derived from the same tissue to identify putative regulators of stemness in vivo...
October 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29072711/seroprevalence-of-anti-hav-total-antibodies-among-workers-in-wastewater-treatment-plants
#19
Elka Ilieva Toseva, Mariya Vasileva Atanasova, Tanya Hristova Turnovska
OBJECTIVES: Data on high frequency of hepatitis A virus (HAV) antibodies for wastewater treatment staff is contradictory. Literature lacks data on the seroprevalence of antibodies to HAV (anti-HAV) among workers in wastewater treatment plants (WWTPs) in Bulgaria. The aim of this study is to establish a specific humoral immune response to hepatitis A virus - anti-HAV total antibodies among staff in WWTPs. MATERIAL AND METHODS: A complex study of health and working conditions included 110 subjects working in 3 WWTPs in Bulgaria (74% of all workers in the 3 studied WWTPs and 20% of all employees in Bulgaria registered in 2014 under the wastewater collection, discharge and treatment code of economic activity)...
October 26, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/29068275/investigation-of-next-generation-sequencing-data-of-klebsiella-pneumoniae-using-web-based-tools
#20
Eva Brhelova, Mariya Antonova, Filip Pardy, Iva Kocmanova, Jiri Mayer, Zdenek Racil, Martina Lengerova
PURPOSE: Rapid identification and characterization of multidrug-resistant Klebsiella pneumoniae strains is necessary due to the increasing frequency of severe infections in patients. The decreasing cost of next-generation sequencing enables us to obtain a comprehensive overview of genetic information in one step. The aim of this study is to demonstrate and evaluate the utility and scope of the application of web-based databases to next-generation sequenced (NGS) data. METHODOLOGY: The whole genomes of 11 clinical Klebsiella pneumoniae isolates were sequenced using Illumina MiSeq...
October 25, 2017: Journal of Medical Microbiology
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