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https://www.readbyqxmd.com/read/29032749/drug-metabolism-as-an-object-of-computational-analysis-by-the-monte-carlo-method
#1
Mariya A Toropova
Metabolism of therapeutic agents in organism is extremely important from a point of view of drug discovery. Unfortunately, experimental estimation of phenomena related to metabolism is available for the limited number of substances. Under such circumstances, the development of computational method to predict endpoints related to metabolism of therapeutic agents becomes attractive alternative for expensive and time-consuming experiments. There are a group of semi-empirical calculations, which are a convenient compromise between a necessity to carry out experiments and the desire to involve in the practical analysis a bigger amount of molecular features related to the impact of different substances on metabolism...
October 10, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29027368/expression-of-fluorescent-proteins-in-lactobacillus-rhamnosus-to-study-host-microbe-and-microbe-microbe-interactions
#2
Irina Spacova, Elke Lievens, Tine Verhoeven, Hans Steenackers, Jos Vanderleyden, Sarah Lebeer, Mariya I Petrova
Probiotic Lactobacillus strains are widely used to benefit human and animal health, although the exact mechanisms behind their interactions with the host and the microbiota are largely unknown. Fluorescent tagging of live probiotic cells is an important tool to unravel their modes of action. In this study, the implementation of different heterologously expressed fluorescent proteins for the labelling of the model probiotic strains Lactobacillus rhamnosusGG (gastrointestinal) and Lactobacillus rhamnosusGR-1 (vaginal) was explored...
October 13, 2017: Microbial Biotechnology
https://www.readbyqxmd.com/read/29019681/cyclobutyl-containing-rigid-analogues-of-threonine-synthesis-and-physical-chemical-properties
#3
Illia O Feskov, Anton V Chernykh, Ivan S Kondratov, Mariya Klyachina, Constantin G Daniliuc, Günter Haufe
Hitherto unknown cis- and trans-1-amino-3-hydroxy-3-methylcyclobutanecarboxylic acids were syn-thesized in multigram scale. The obtained compounds can be considered as achiral conformationally restricted analogues of threonine with fixed spatial orientation of functional groups. pKa values are noticeably different for both amino acids. According to the X-ray data the cyclobutane rings in both compounds are almost planar (the corresponding torsion angles are below 7°).
October 11, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29017563/herceptin%C3%A2-trastuzumab-in-her2-positive-early-breast-cancer-protocol-for-a-systematic-review-and-cumulative-network-meta-analysis
#4
Florence R Wilson, Megan E Coombes, Quinlan Wylie, Mariya Yurchenko, Christine Brezden-Masley, Brian Hutton, Becky Skidmore, Chris Cameron
BACKGROUND: Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is an aggressive disease that makes up about 20% of all invasive breast cancers. HER2+ breast cancer is associated with poor prognosis and high mortality rates, but the development of HER2-targeted therapies, such as originator trastuzumab (Herceptin®), has substantially improved patient survival. Numerous clinical trials and reviews have investigated the efficacy of HER2-targeted therapies over the past few decades; however, no study has specifically investigated the vast body of evidence on trastuzumab in comparison to chemotherapy regimens, endocrine therapies, and other targeted therapies...
October 10, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28989533/trityl-based-alkoxyamines-as-nmp-controllers-and-spin-labels
#5
Gérard Audran, Elena G Bagryanskaya, Paul Brémond, Mariya V Edeleva, Sylvain R A Marque, Dmitriy A Parkhomenko, Olga Yu Rogozhnikova, Victor M Tormyshev, Evgeny V Tretyakov, Dmitry V Trukhin, Svetlana I Zhivetyeva
Recently, new applications of trityl-nitroxide biradicals were proposed. In the present study, attachment of a trityl radical to alkoxyamines was performed for the first time. The rate constants kd of C-ON bond homolysis in these alkoxyamines were measured and found to be equal to those for alkoxyamines without trityl. The electron paramagnetic resonance (EPR) spectra of the products of alkoxyamine homolysis (trityl-TEMPO and trityl-SG1 biradicals) were recorded, and the corresponding exchange interactions were estimated...
November 14, 2016: Polymer Chemistry
https://www.readbyqxmd.com/read/28976899/community-noise-exposure-and-its-effect-on-blood-pressure-and-renal-function-in-patients-with-hypertension-and-cardiovascular-disease
#6
Angel M Dzhambov, Mariya P Tokmakova, Penka D Gatseva, Nikolai G Zdravkov, Dolina G Gencheva, Nevena G Ivanova, Krasimir I Karastanev, Stefka V Vladeva, Aleksandar T Donchev, Svetlan M Dermendzhiev
BACKGROUND: Road traffic noise (RTN) is a risk factor for cardiovascular disease (CVD) and hypertension; however, few studies have looked into its association with blood pressure (BP) and renal function in patients with prior CVD. AIM: This study aimed to explore the effect of residential RTN exposure on BP and renal function in patients with CVD from Plovdiv Province. MATERIALS AND METHODS: We included 217 patients with ischemic heart disease and/or hypertension from three tertiary hospitals in the city of Plovdiv (March - May 2016)...
September 1, 2017: Folia Medica
https://www.readbyqxmd.com/read/28970846/sentinel-lymph-node-biopsy-in-breast-cancer-a-clinical-review-and-update
#7
REVIEW
Sheikh Zahoor, Altaf Haji, Azhar Battoo, Mariya Qurieshi, Wahid Mir, Mudasir Shah
Sentinel lymph node biopsy has become a standard staging tool in the surgical management of breast cancer. The positive impact of sentinel lymph node biopsy on postoperative negative outcomes in breast cancer patients, without compromising the oncological outcomes, is its major advantage. It has evolved over the last few decades and has proven its utility beyond early breast cancer. Its applicability and efficacy in patients with clinically positive axilla who have had a complete clinical response after neoadjuvant chemotherapy is being aggressively evaluated at present...
September 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/28966554/larch-forests-of-middle-siberia-long-term-trends-in-fire-return-intervals
#8
Viacheslav I Kharuk, Mariya L Dvinskaya, Ilya A Petrov, Sergei T Im, Kenneth J Ranson
Fire history within the northern larch forests of Central Siberia was studied (65+°N). Fires within this area are predominantly caused by lightning strikes rather than human activity. Mean fire return intervals (FRI) were found to be 112 ± 49 years (based on fire scars) and 106 ± 36 years (based on fire scars and tree natality dates). FRI were increased with latitude increase, and observed to be about 80 years at 64°N, about 200 years near the Arctic Circle, and about 300 years nearby the northern range limit of larch stands (~71°+N)...
December 2016: Regional Environmental Change
https://www.readbyqxmd.com/read/28956133/the-effects-of-mild-germinal-matrix-intraventricular-haemorrhage-on-the-developmental-white-matter-microstructure-of-preterm-neonates-a-dti-study
#9
Domenico Tortora, Carola Martinetti, Mariasavina Severino, Sara Uccella, Mariya Malova, Alessandro Parodi, Fabia Brera, Giovanni Morana, Luca Antonio Ramenghi, Andrea Rossi
OBJECTIVES: To evaluate white matter (WM) microstructural changes in preterm neonates (PN) with mild germinal matrix-intraventricular haemorrhage (mGMH-IVH) (grades I and II) and no other associated MRI abnormalities, and correlate them with gestational age (GA) and neurodevelopmental outcome. METHODS: Tract-based spatial-statistics (TBSS) was performed on DTI of 103 patients studied at term-equivalent age, to compare diffusional parameters (fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), axial diffusivity (AD)) between mGMH-IVH neonates (24/103) and controls matched by GA at birth and sex...
September 27, 2017: European Radiology
https://www.readbyqxmd.com/read/28952643/how-intramolecular-hydrogen-bonding-ihb-controls-the-c-on-bond-homolysis-in-alkoxyamines
#10
Gérard Audran, Raphael Bikanga, Paul Brémond, Mariya Edeleva, Jean-Patrick Joly, Sylvain R A Marque, Paulin Nkolo, Valérie Roubaud
Recent amazing results (Nkolo et al., Org. Biomol. Chem., 2017, 6167) on the effect of solvents and polarity on the C-ON bond homolysis rate constants kd of alkoxyamine R1R2NOR3 led us to re-investigate the antagonistic effect of intramolecular hydrogen-bonding (IHB) on kd. Here, IHB is investigated both in the nitroxyl fragment R1R2NO and in the alkyl fragment R3, as well as between fragments, that is, the donating group on the alkyl fragment and the accepting group on the nitroxyl fragment, and conversely...
October 11, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28941477/snapshotdx-quiz-october-2017
#11
Laura Scott, Mariya Miteva
No abstract text is available yet for this article.
October 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28936202/cell-surface-properties-of-lactococcus-lactis-reveal-milk-protein-binding-specifically-evolved-in-dairy-isolates
#12
Mariya Tarazanova, Thom Huppertz, Marke Beerthuyzen, Saskia van Schalkwijk, Patrick Janssen, Michiel Wels, Jan Kok, Herwig Bachmann
Surface properties of bacteria are determined by the molecular composition of the cell wall and they are important for interactions of cells with their environment. Well-known examples of bacterial interactions with surfaces are biofilm formation and the fermentation of solid materials like food and feed. Lactococcus lactis is broadly used for the fermentation of cheese and buttermilk and it is primarily isolated from either plant material or the dairy environment. In this study, we characterized surface hydrophobicity, charge, emulsification properties, and the attachment to milk proteins of 55 L...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28921945/multiwalled-carbon-nanotubes-dramatically-affect-the-fruit-metabolome-of-exposed-tomato-plants
#13
Diamond L McGehee, Mohamed H Lahiani, Fahmida Irin, Micah J Green, Mariya V Khodakovskaya
Here, we reported that multiwalled carbon nanotubes (MWCNT) added to hydroponics system can enhance fruit production of exposed tomato plants. We quantified the exact amount of MWCNT accumulated inside of fruits collected by MWCNT-exposed plants using an advanced microwave induced heating technique (MIH). We found that absorption of MWCNT by tomato fruits significantly affected total fruit metabolome as was confirmed by LC-MS. Our data highlight the importance of comprehensive toxicological risk assessment of plants contaminated with carbon nanomaterials...
September 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28921600/injury-patterns-sustained-in-fatal-motor-vehicle-collisions-with-driver-s-third-generation-airbag-deployment
#14
Mariya Kuk, Michael J Shkrum
The Office of the Chief Coroner for Ontario database for 2011-2012 was used to compare fatal injury patterns in drivers whose third-generation airbags deployed compared to first- and second-generation airbag deployments and airbag nondeployments with and without seatbelt use. There were 110 frontal and offset frontal crashes analyzed. The small sample size meant that the odds of craniocerebral, cervical spinal, thoracic, and abdominal injuries were not statistically different for airbag generation, deployment status, and seatbelt use; however, the risk of fatal thoracic injuries in third- and second-generation cases was increased...
September 15, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28919703/quality-and-learning-curve-of-handheld-versus-stand-alone-non-mydriatic-cameras
#15
Mariya Gosheva, Christian Klameth, Lars Norrenberg, Lucien Clin, Johannes Dietter, Wadood Haq, Iliya V Ivanov, Focke Ziemssen, Martin A Leitritz
PURPOSE: Nowadays, complex digital imaging systems allow detailed retinal imaging without dilating patients' pupils. These so-called non-mydriatic cameras have advantages in common circumstances (eg, for screening or emergency purposes) but present limitations in terms of image quality and field of view. We compare the usefulness of two non-mydriatic camera systems (ie, a handheld versus a stand-alone device) for fundus imaging. The primary outcome was image quality. The secondary outcomes were learning effects and quality grade-influencing factors...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28902331/quantitative-and-qualitative-features-of-spectral-domain-optical-coherence-tomography-provide-prognostic-indicators-for-visual-acuity-in-patients-with-choroideremia
#16
Alessandro Abbouda, Wei Sing Lim, Lina Sprogyte, Andrew R Webster, Mariya Moosajee
BACKGROUND AND OBJECTIVE: To identify qualitative and quantitative features of spectral-domain optical coherence tomography (SD-OCT) as prognostic indicators of visual acuity (VA) loss in patients with choroideremia (CHM). PATIENTS AND METHODS: Retrospective study of 57 male patients with CHM. Central foveal thickness (CFT), subfoveal choroidal thickness (SCT), fundus autofluorescence area, and evidence of outer retinal and choroidal degeneration were analyzed by SD-OCT...
September 1, 2017: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/28899688/keratins-regulate-the-adhesive-properties-of-desmosomal-cadherins-through-signaling
#17
Franziska Vielmuth, Marie-Therès Wanuske, Mariya Y Radeva, Matthias Hiermaier, Daniela Kugelmann, Elias Walter, Fanny Buechau, Thomas M Magin, Jens Waschke, Volker Spindler
Tightly controlled intercellular adhesion is crucial for integrity and function of the epidermis. The keratin filament cytoskeleton anchors desmosomes, supramolecular complexes required for strong intercellular adhesion. We here tested whether keratin filaments control cell adhesion by regulating the adhesive properties of desmosomal cadherins such as desmoglein (Dsg) 3. Atomic force microscopy (AFM) and FRAP experiments revealed reduced Dsg3 adhesive forces and membrane stability in murine keratinocytes lacking all keratin filaments...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28887611/toxicity-uptake-and-accumulation-of-nano-and-bulk-cerium-oxide-particles-in-artemia-salina
#18
Einstein Mariya David Sugantharaj David, Madhav Madurantakam Royam, Suresh Kumar Rajamani Sekar, Bhuvaneshwari Manivannan, Swathy Jalaja Soman, Amitava Mukherjee, Chandrasekaran Natarajan
Although the toxicological impact of metal oxide nanoparticles has been studied for the last few decades on aquatic organisms, the exact mechanism of action is still unclear. The fate, behavior, and biological activity of nanoparticles are dependent on physicochemical factors like size, shape, surface area, and stability in the medium. This study deals with the effect of nano and bulk CeO2 particles on marine microcrustacean, Artemia salina. The primary size was found to be 15 ± 3.5 and 582 ± 50 nm for nano and bulk CeO2 (TEM), respectively...
September 8, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28880920/the-staphylococcus-aureus-superantigen-selx-is-a-bifunctional-toxin-that-inhibits-neutrophil-function
#19
Stephen W Tuffs, David B A James, Jovanka Bestebroer, Amy C Richards, Mariya I Goncheva, Marie O'Shea, Bryan A Wee, Keun Seok Seo, Patrick M Schlievert, Andreas Lengeling, Jos A van Strijp, Victor J Torres, J Ross Fitzgerald
Bacterial superantigens (SAgs) cause Vβ-dependent T-cell proliferation leading to immune dysregulation associated with the pathogenesis of life-threatening infections such as toxic shock syndrome, and necrotizing pneumonia. Previously, we demonstrated that staphylococcal enterotoxin-like toxin X (SElX) from Staphylococcus aureus is a classical superantigen that exhibits T-cell activation in a Vβ-specific manner, and contributes to the pathogenesis of necrotizing pneumonia. Here, we discovered that SElX can also bind to neutrophils from human and other mammalian species and disrupt IgG-mediated phagocytosis...
September 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28879187/clinical-and-dermoscopic-features-of-the-scalp-in-31-patients-with-dermatomyositis
#20
Julio C Jasso-Olivares, Antonella Tosti, Mariya Miteva, Judith Domínguez-Cherit, José M Díaz-González
BACKGROUND: Scalp involvement is not directly evaluated in patients with dermatomyositis (DM). Therefore, the exact frequency of scalp dermatomyositis (SDM) and its clinical and trichoscopic characteristics have been poorly described. OBJECTIVE: The aim of this study was to determine the frequency and clinical and dermoscopic features of SDM in patients diagnosed with DM. METHODS: We performed a descriptive prospective, cross-sectional observational study that included all patients diagnosed with DM at a Mexican academic institute over the course of a year...
August 2017: Skin Appendage Disorders
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