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https://www.readbyqxmd.com/read/29461475/octodrine-new-questions-and-challenges-in-sport-supplements
#1
Valeria Catalani, Mariya Prilutskaya, Ahmed Al-Imam, Shanna Marrinan, Yasmine Elgharably, Mire Zloh, Giovanni Martinotti, Robert Chilcott, Ornella Corazza
Background : Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950's, it has recently been re-introduced on the market as a pre-workout and 'fat-burner' product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades. Methods : A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic...
February 20, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29457017/distinct-trichoscopic-features-of-the-sideburns-in-frontal-fibrosing-alopecia-compared-to-the-frontotemporal-scalp
#2
Jessica Cervantes, Mariya Miteva
The trichoscopic features of frontal fibrosing alopecia (FFA) have been described in the frontotemporal area, yet there is no data detailing the trichoscopic features of the sideburns, which can be the initial or exclusive area of involvement. In this retrospective cohort study, 236 trichoscopic images of the frontotemporal and sideburn area obtained via dry trichoscopy from patients with biopsy-proven FFA were examined by two independent researchers to determine the trichoscopic features of FFA in the sideburns...
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29457016/red-dots-in-a-net-like-pattern-on-the-upper-chest-a-novel-clinical-observation-in-frontal-fibrosing-alopecia-and-fibrosing-alopecia-in-pattern-distribution
#3
Victoria Billero, Kate E Oberlin, Mariya Miteva
No abstract text is available yet for this article.
January 2018: Skin Appendage Disorders
https://www.readbyqxmd.com/read/29456161/the-effect-of-lrrk2-mutations-on-the-cholinergic-system-in-manifest-and-premanifest-stages-of-parkinson-s-disease-a-cross-sectional-pet-study
#4
Shu-Ying Liu, Daryl J Wile, Jessie Fanglu Fu, Jason Valerio, Elham Shahinfard, Siobhan McCormick, Rostom Mabrouk, Nasim Vafai, Jess McKenzie, Nicole Neilson, Alexandra Perez-Soriano, Julieta E Arena, Mariya Cherkasova, Piu Chan, Jing Zhang, Cyrus P Zabetian, Jan O Aasly, Zbigniew K Wszolek, Martin J McKeown, Michael J Adam, Thomas J Ruth, Michael Schulzer, Vesna Sossi, A Jon Stoessl
BACKGROUND: Markers of neuroinflammation are increased in some patients with LRRK2 Parkinson's disease compared with individuals with idiopathic Parkinson's disease, suggesting possible differences in disease pathogenesis. Previous PET studies have suggested amplified dopamine turnover and preserved serotonergic innervation in LRRK2 mutation carriers. We postulated that patients with LRRK2 mutations might show abnormalities of central cholinergic activity, even before the diagnosis of Parkinson's disease...
February 15, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29454828/evaluation-of-%C3%AE-glucosidase-inhibiting-potentials-with-docking-calculations-of-synthesized-arylidene-pyrazolones
#5
Faryal Chaudhry, Sadia Naureen, Shahnaz Choudhry, Rahila Huma, Muhammad Ashraf, Mariya Al-Rashida, Bakhat Jahan, Masooma Hyder Khan, Farah Iqbal, Munawar Ali Munawar, Misbahul Ain Khan
Herein, condensation of aryl(hetaryl)pyrazole-4-carbaldehydes 1(a-c) with substituted pyrazolones 2(a-d) lead to the corresponding arylidene-pyrazolones 3(a-l) which were tested against α-glucosidase enzyme. The synthesized compounds displayed moderate to good activity. Among these, a coumarin derivative 3k exhibited excellent results (IC50 2.10 ± 0.004 µM) in comparison to clinical drug acarbose (IC50 37.38 ± 0.12 µM). The ligand-protein interactions were identified through docking and stabilizing energy calculations...
February 10, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29444950/mirna-targeting-and-alternative-splicing-in-the-stress-response-events-hosted-by-membrane-less-compartments
#6
REVIEW
Mariya M Kucherenko, Halyna R Shcherbata
Stress can be temporary or chronic, and mild or acute. Depending on its extent and severity, cells either alter their metabolism, and adopt a new state, or die. Fluctuations in environmental conditions occur frequently, and such stress disturbs cellular homeostasis, but in general, stresses are reversible and last only a short time. There is increasing evidence that regulation of gene expression in response to temporal stress happens post-transcriptionally in specialized subcellular membrane-less compartments called ribonucleoprotein (RNP) granules...
February 14, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29444881/ischaemic-stroke-haemorrhage-and-mortality-in-older-patients-with-chronic-kidney-disease-newly-started-on-anticoagulation-for-atrial-fibrillation-a-population-based-study-from-uk-primary-care
#7
Shankar Kumar, Simon de Lusignan, Andrew McGovern, Ana Correa, Mariya Hriskova, Piers Gatenby, Simon Jones, David Goldsmith, A John Camm
OBJECTIVE: To assess the association between anticoagulation, ischaemic stroke, gastrointestinal and cerebral haemorrhage, and all cause mortality in older people with atrial fibrillation and chronic kidney disease. DESIGN: Propensity matched, population based, retrospective cohort analysis from January 2006 through December 2016. SETTING: The Royal College of General Practitioners Research and Surveillance Centre database population of almost 2...
February 14, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29428460/severe-hantavirus-disease-in-children
#8
Tamara K Dzagurova, Evgeniy A Tkachenko, Aydar A Ishmukhametov, Mariya V Balovneva, Boris Klempa, Detlev H Kruger
BACKGROUND: Very recently, a novel European hantavirus, Sochi virus, has been discovered which causes severe courses of hantavirus disease with a case fatality rate of about 15 percent. OBJECTIVES: We aimed to study to which extent and with which clinical severity children were affected by Sochi virus infection. STUDY DESIGN: Sochi virus infection of patients was confirmed by molecular, serological, and epizoonotic studies. Clinical and laboratory parameters were analyzed for the age group of up to 15 years (n = 6) in comparison to all older patients (n = 56)...
January 31, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29424559/bayesian-latent-class-analysis-tutorial
#9
Yuelin Li, Jennifer Lord-Bessen, Mariya Shiyko, Rebecca Loeb
This article is a how-to guide on Bayesian computation using Gibbs sampling, demonstrated in the context of Latent Class Analysis (LCA). It is written for students in quantitative psychology or related fields who have a working knowledge of Bayes Theorem and conditional probability and have experience in writing computer programs in the statistical language R . The overall goals are to provide an accessible and self-contained tutorial, along with a practical computation tool. We begin with how Bayesian computation is typically described in academic articles...
February 9, 2018: Multivariate Behavioral Research
https://www.readbyqxmd.com/read/29423837/analysis-of-hedgehog-signaling-in-periocular-sebaceous-carcinoma
#10
John C Bladen, Mariya Moosajee, Dhani Tracey-White, Michèle Beaconsfield, Edel A O'Toole, Michael P Philpott
PURPOSE: Sebaceous carcinoma (SC) is a clinical masquerader of benign conditions resulting in significant eye morbidity, sometimes leading to extensive surgical treatment including exenteration, and even mortality. Little is known about the genetic or molecular basis of SC. This study identifies the involvement of Hedgehog (Hh) signaling in periocular SC. METHODS: Fifteen patients with periocular SC patients were compared to 15 patients with eyelid nodular basal cell carcinoma (nBCC; a known Hh tumor), alongside four normal individuals as a control for physiological Hh expression...
February 8, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29409918/horizontal-and-vertical-sections-of-scalp-biopsy-specimens-from-dermatomyositis-patients-with-scalp-involvement
#11
Julio Jasso-Olivares, José Manuel Diaz-Gonzalez, Mariya Miteva
BACKGROUND: The histologic findings of scalp involvement in dermatomyositis are not well characterized due to lack of large series. OBJECTIVE: To systematize the histologic features of scalp involvement in dermatomyositis on horizontal and vertical sections. MATERIALS AND METHODS: A descriptive, prospective, cross-sectional study recruited 31 patients with pathologically and serologically confirmed dermatomyositis in Mexico City from June 2014 to June 2015...
January 30, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29407609/regulation-of-alternative-oxidase-1-in-chlamydomonas-reinhardtii-during-sulfur-starvation
#12
Zhanneta Zalutskaya, Valentina Filina, Mariya Ostroukhova, Elena Ermilova
The mitochondrial respiratory chain in plants, some protists and many fungi consists of the ATP-coupling cyanide-sensitive cytochrome pathway and the cyanide-resistant alternative respiratory pathway. The alternative pathway is mediated by alternative oxidase (AOX). Although AOX has been proposed to play essential roles in nutrient stress tolerance of plants and protists, the effects of sulfur (S) deprivation, on AOX are largely unknown. The unicellular green alga Chlamydomonas reinhardtii reacts to S limitation conditions with the induced expression of many genes...
January 12, 2018: European Journal of Protistology
https://www.readbyqxmd.com/read/29402914/neuroprotection-of-the-hypoxic-ischemic-mouse-brain-by-human-cd117-cd90-cd105-amniotic-fluid-stem-cells
#13
Michelangelo Corcelli, Kate Hawkins, Filipa Vlahova, Avina Hunjan, Kate Dowding, Paolo De Coppi, Anna L David, Donald Peebles, Pierre Gressens, Henrik Hagberg, Mariya Hristova, Pascale V Guillot
Human amniotic fluid contains two morphologically-distinct sub-populations of stem cells with regenerative potential, spindle-shaped (SS-hAFSCs) and round-shaped human amniotic fluid stem cells (RS-hAFSCs). However, it is unclear whether morphological differences correlate with functionality, and this lack of knowledge limits their translational applications. Here, we show that SS-hAFSCs and RS-hAFSCs differ in their neuro-protective ability, demonstrating that a single contralateral injection of SS-hAFSCs into hypoxic-ischemic P7 mice conferred a 47% reduction in hippocampal tissue loss and 43-45% reduction in TUNEL-positive cells in the hippocampus and striatum 48 hours after the insult, decreased microglial activation and TGFβ1 levels, and prevented demyelination...
February 5, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29399825/testing-tele-savvy-protocol-for-a-randomized-controlled-trial
#14
Mariya A Kovaleva, Elizabeth Bilsborough, Patricia C Griffiths, Joe Nocera, Melinda Higgins, Fayron Epps, Katie Kilgore, Allison Lindauer, Darby Morhardt, Raj C Shah, Kenneth Hepburn
Many informal caregivers of persons with dementia suffer adverse health consequences. Although established psychoeducation programs are known to benefit caregivers, attending in-person programs is challenging for them. To address this challenge, the Savvy Caregiver Program, an evidence-based psychoeducation program with demonstrated effectiveness for caregiving and disease-related outcomes, was transformed into an on-line program, Tele-Savvy. This article describes the rationale for and design of a prospective longitudinal randomized controlled trial (targeted N = 215), currently underway...
February 5, 2018: Research in Nursing & Health
https://www.readbyqxmd.com/read/29391378/the-cost-of-mental-and-physical-health-disability-in-childhood-and-adolescence-to-families-in-the-uk-findings-from-a-repeated-cross-sectional-survey-using-propensity-score-matching
#15
Francesca Solmi, Mariya Melnychuk, Stephen Morris
OBJECTIVE: In the UK, families of disabled children are entitled to receive disability benefits to help meet costs associated with caring for their child. Evidence of actual costs incurred is scant, especially for mental health disability. In this study, we aimed to quantify the cost of mental and physical health disability in childhood and adolescence to families in the UK using the concept of compensating variation (CV). DESIGN: Repeated cross-sectional survey...
February 1, 2018: BMJ Open
https://www.readbyqxmd.com/read/29386111/modeling-congenital-adrenal-hyperplasia-and-testing-interventions-for-adrenal-insufficiency-using-donor-specific-reprogrammed-cells
#16
Gerard Ruiz-Babot, Mariya Balyura, Irene Hadjidemetriou, Sharon J Ajodha, David R Taylor, Lea Ghataore, Norman F Taylor, Undine Schubert, Christian G Ziegler, Helen L Storr, Maralyn R Druce, Evelien F Gevers, William M Drake, Umasuthan Srirangalingam, Gerard S Conway, Peter J King, Louise A Metherell, Stefan R Bornstein, Leonardo Guasti
Adrenal insufficiency is managed by hormone replacement therapy, which is far from optimal; the ability to generate functional steroidogenic cells would offer a unique opportunity for a curative approach to restoring the complex feedback regulation of the hypothalamic-pituitary-adrenal axis. Here, we generated human induced steroidogenic cells (hiSCs) from fibroblasts, blood-, and urine-derived cells through forced expression of steroidogenic factor-1 and activation of the PKA and LHRH pathways. hiSCs had ultrastructural features resembling steroid-secreting cells, expressed steroidogenic enzymes, and secreted steroid hormones in response to stimuli...
January 30, 2018: Cell Reports
https://www.readbyqxmd.com/read/29380947/photodynamic-opening-of-the-blood-brain-barrier-and-pathways-of-brain-clearing
#17
Oxana Semyachkina-Glushkovskaya, Vladimir Chehonin, Ekaterina Borisova, Ivan Fedosov, Anton Namykin, Arkady Abdurashitov, Alexander Shirokov, Boris Khlebtsov, Yelena Lyubun, Nikita Navolokin, Mariya Ulanova, Natalia Shushunova, Alexander Khorovodov, Ilana Agranovich, Anastasia Bodrova, Madina Sagatova, Ali Esmat Shareef, Elena Saranceva, Tatyana Iskra, Mariya Dvoryatkina, Ekaterina Zhinchenko, Olga Sindeeva, Valery Tuchin, Jurgen Kurths
A new application of the photodynamic treatment (PDT) is presented for the opening of blood-brain barrier (BBB) and the brain clearing activation that is associated with it, including the use of gold nanoparticles as emerging photosensitizer carriers in PDT. The obtained results clearly demonstrate two pathways for the brain clearing: 1) using PDT-opening of BBB and intravenous injection of FITC-dextran we showed a clearance of this tracer via the meningeal lymphatic system in the subdural space; 2) using optical coherence tomography and intra-parenchymal injection of gold nanorods we observed their clearance through the exit gate of cerebral spinal fluid from the brain into the deep cervical lymph node, where the gold nanorods were accumulated...
January 30, 2018: Journal of Biophotonics
https://www.readbyqxmd.com/read/29368977/quinazoline-and-quinazolinone-as-important-medicinal-scaffoldes-a-comparative-patent-review-2011-2016
#18
Abdul Hameed, Mariya Al-Rashida, Maliha Uroos, Syed Abid Ali, Arshia, Marium Ishtiaq, Khalid Mohammed Khan
Quinazoline and quinazolinone scaffolds represent an important class of biologically active nitrogen heterocyclic compounds. A variety of marketed drugs are based on these moieties. A diverse range of molecules with quinazoline/quinazolinone moieties have been reported to exhibit broad spectrum of biological activities. Area covered: This review covers recent efforts in the synthesis and biological screening of quinazoline/quinazolinone based compounds from 2011-2016. Expert Opinion: Quinazoline and quinazolinones represent a diverse class of biologically active nitrogen heterocyclic compounds with immense therapeutic potential...
January 25, 2018: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/29366096/management-of-high-and-very-high-risk-patients-with-familial-hypercholesterolemia-results-from-an-observational-study-in-bulgaria
#19
Ivo Petrov, Arman Postadzhiyan, Mariya Tokmakova, Janet Addison, Reneta Petkova
No abstract text is available yet for this article.
August 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29366001/risk-assessment-for-diabetes-mellitus-type-2-in-women
#20
Albena Nikolova, Mariya Milanova, Konstantin Stoyanov, Georgi Yankov
No abstract text is available yet for this article.
August 2017: Atherosclerosis
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