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https://www.readbyqxmd.com/read/28532761/snapshotdx-quiz-june-2017
#1
Janelle Pavlis, Mariya Miteva
No abstract text is available yet for this article.
June 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28521172/hetarylcoumarins-synthesis-and-biological-evaluation-as-potent-%C3%AE-glucosidase-inhibitors
#2
Faryal Chaudhry, Shahnaz Choudhry, Rahila Huma, Muhammad Ashraf, Mariya Al-Rashida, Rubina Munir, Ramsha Sohail, Bakhat Jahan, Munawar Ali Munawar, Misbahul Ain Khan
In search of better α-glucosidase inhibitors, a series of novel hetarylcoumarins (3a-3j) were designed and synthesized through a facile multicomponent route where p-toluenesulfonic acid (PTSA) was explored as an efficient catalyst. These new scaffolds were further evaluated for their α-glucosidase inhibition potentials. All the derivatives exhibited good to excellent results which were comparable or even better than of standard drug acarbose. Of these compounds, a dihalogenated compound 3f was found to be the most effective one with IC50: 2...
May 10, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/28520210/biases-in-the-reporting-of-hcc-tumor-sizes-on-the-liver-transplant-waiting-list
#3
Mariya L Samoylova, Mark J Nigrini, Jennifer L Dodge, John P Roberts
We investigate the possibility that patients with hepatocellular carcinoma (HCC) listed for liver transplant with tumors just outside Stage T2 size criteria may be inaccurately reported as just meeting the tumor size criteria for transplant. The UNOS/STAR database identified 12,958 patients listed for liver transplants with HCC exception points from 2006-2013, 9,168 of whom were listed with one tumor. A logistic power peak function was fitted to the single-tumor size histogram, with the fitted values representing unbiased expected values...
May 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28494764/possible-benefits-of-tomato-juice-consumption-a-pilot-study-on-irradiated-human-lymphocytes-from-healthy-donors
#4
Ayumi Nakamura, Chieko Itaki, Ayako Saito, Toko Yonezawa, Koichi Aizawa, Ayumi Hirai, Hiroyuki Suganuma, Tomisato Miura, Yasushi Mariya, Siamak Haghdoost
BACKGROUND: Reactive oxygen species (ROS) mediate much of the DNA damage caused by ionizing radiation. Among carotenoids, lycopene and β-carotene, present in tomato juice, are known to be strong radical scavengers. The aim of the study was to investigate the effect of tomato juice intake on the levels of DNA damage and oxidative stress in human whole blood induced by in vitro exposure to X-rays. METHODS: Ten healthy adults were asked to drink 190 g of tomato juice, containing 17 mg lycopene and 0...
May 12, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28494614/evaluation-of-pigments-from-methanolic-extract-of-tagetes-erecta-and-beta-vulgaris-as-antioxidant-and-antibacterial-agent
#5
Mariya Saani, Reena Lawrence, Kapil Lawrence
The Total Phenolic Content (TPC), antioxidant and antibacterial activities of methanolic extract of Marigold flower (MF) (Tagetes erecta) and Beet root (BR) (Beta vulgaris) were examined. The present work reveals that MF contained greater amount of TPC (42.5 mg/g GAE) as compared to BR (39.4 mg/g GAE). Methanolic extract of MF exhibited excellent DPPH free radical scavenging power (IC50 0.0716 mg/mL) and reducing power at 1 mg/mL concentration. Similar results have been obtained in FTC and TBA method. The results of antibacterial test indicated that the methanolic extract of MF and BR is significantly effective against both type of Gram-negative (Escherichia coli, Shigella dysenteriae) and Gram-positive (Bacillus subtilis, Staphylococcus aureus) bacterial strains...
May 11, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28485474/graphene-and-carbon-nanotubes-activate-different-cell-surface-receptors-on-macrophages-before-and-after-deactivation-of-endotoxins
#6
Mohamed H Lahiani, Kuppan Gokulan, Katherine Williams, Mariya V Khodakovskaya, Sangeeta Khare
Nanomaterial synthesis and handling in a non-sterile environment can result in the final product becoming contaminated with bacterial endotoxin or lipopolysaccharides (LPB). During toxicological testing, the effects caused by endotoxin-contaminated nanomaterials can be misinterpreted in the end-point analysis (such as cytotoxicity and immune responses) and could result in erroneous conclusions. The objective of this study was twofold: (i) to test different carbon-based nanomaterials (CBNs) [pristine graphene and multi-wall carbon nanotubes (MWCNTs)] for the presence of endotoxin and develop strategies for depyrogenation, and (ii) to compare the immune response exhibited by macrophages after exposure to native CBNs versus depyrogenated CBNs...
May 9, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28483546/impact-of-a-structured-report-template-on-the-quality-of-ct-and-mri-reports-for-hepatocellular-carcinoma-diagnosis
#7
Milana Flusberg, Jeremy Ganeles, Tulay Ekinci, Shlomit Goldberg-Stein, Viktoriya Paroder, Mariya Kobi, Victoria Chernyak
PURPOSE: To assess the impact of a Liver Imaging Reporting and Data System (LI-RADS) structured template on quality of reports for hepatocellular carcinoma (HCC). MATERIALS AND METHODS: A departmental structured LI-RADS template was adopted in April 2015. CT and MRI reports from September 2014 to February 2016 with probable or definite HCC were reviewed. Reporting of the following was recorded for each lesion and compared between template and free-text reports: (1) LI-RADS category, (2) Couinaud segment, and (3) unequivocal description of presence or absence of major LI-RADS HCC features: arterial phase hyperenhancement, "washout," diameter, threshold growth, and "capsule...
May 5, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/28478907/con-routine-use-of-brain-perfusion-techniques-is-not-supported-in-deep-hypothermic-circulatory-arrest
#8
Mariya Geube, Shiva Sale, Lars Svensson
No abstract text is available yet for this article.
February 4, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28472537/phase-1-2-study-of-rilotumumab-amg-102-a-hepatocyte-growth-factor-inhibitor-and-erlotinib-in-patients-with-advanced-non-small-cell-lung-cancer
#9
Ahmad A Tarhini, Imran Rafique, Theofanis Floros, Phu Tran, William E Gooding, Liza C Villaruz, Timothy F Burns, David M Friedland, Daniel P Petro, Mariya Farooqui, Jose Gomez-Garcia, Autumn Gaither-Davis, Sanja Dacic, Athanassios Argiris, Mark A Socinski, Laura P Stabile, Jill M Siegfried
BACKGROUND: Activation of the mesenchymal-epidermal transition factor (MET) tyrosine kinase and its ligand, hepatocyte growth factor (HGF), is implicated in resistance to epidermal growth factor receptor (EGFR) inhibitors. In this phase 1/2 trial, rilotumumab (an anti-HGF antibody) combined with erlotinib was evaluated in patients with metastatic, previously treated non-small cell lung cancer. METHODS: In phase 1, a dose de-escalation design was adopted with rilotumumab starting at 15 mg/kg intravenously every 3 weeks and oral erlotinib 150 mg daily...
May 4, 2017: Cancer
https://www.readbyqxmd.com/read/28465619/the-rational-design-of-therapeutic-peptides-for-aminopeptidase-n-using-a-substrate-based-approach
#10
Shilvi Joshi, Lang Chen, Michael B Winter, Yi-Lun Lin, Yang Yang, Mariya Shapovalova, Paige M Smith, Chang Liu, Fang Li, Aaron M LeBeau
The M1 family of metalloproteases represents a large number of exopeptidases that cleave single amino acid residues from the N-terminus of peptide substrates. One member of this family that has been well studied is aminopeptidase N (APN), a multifunctional protease known to cleave biologically active peptides and aide in coronavirus entry. The proteolytic activity of APN promotes cancer angiogenesis and metastasis making it an important target for cancer therapy. To understand the substrate specificity of APN for the development of targeted inhibitors, we used a global substrate profiling method to determine the P1-P4' amino acid preferences...
May 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28460557/an-online-program-for-caregivers-of-persons-living-with-dementia-lessons-learned
#11
Mariya Kovaleva, Lindsey Blevins, Patricia C Griffiths, Kenneth Hepburn
The population of individuals living with dementia and their caregivers and the need to provide caregiver training will increase in the next several decades. In-person caregiver educational programs are delimited by logistical and resource boundaries that could be overcome with online programs. The purpose of this qualitative descriptive study was to explore the acceptability and ways to improve the content and delivery of an online 7-week psychoeducational pilot program-Tele-Savvy. Thirty-six caregivers who completed the pilot were interviewed about their experience with Tele-Savvy and their suggestions for its improvement...
April 1, 2017: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/28458517/a-comparative-study-on-endovascular-treatment-of-sub-acute-critical-limb-ischemia-mechanical-thrombectomy-vs-thrombolysis
#12
Mariya Kronlage, Ilka Printz, Britta Vogel, Erwin Blessing, Oliver J Müller, Hugo A Katus, Christian Erbel
OBJECTIVE: The aim of this study was to compare different interventional methods for treatment of (sub)acute limb ischemia upon thrombotic occlusions of the lower extremity in terms of their safety and efficacy in a tertiary hospital setting. DESIGN: This is a retrospective, single-center study of non-randomized data. METHODS: A total of 202 patients, including 26 critically ill patients, underwent rotational thrombectomy (Rotarex(®)), local thrombolysis (recombinant tissue plasminogen activator), or combination of both at the University Hospital Heidelberg (2006-2015)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28454023/toxicity-and-accumulation-of-copper-oxide-cuo-nanoparticles-in-different-life-stages-of-artemia-salina
#13
M R Madhav, S Einstein Mariya David, R S Suresh Kumar, J S Swathy, M Bhuvaneshwari, Amitava Mukherjee, N Chandrasekaran
Metal nanoparticles production rate and its applications have raised concerns about their release and toxicity to the aquatic and terrestrial organisms. The primary size of Copper Oxide nanoparticles (CuO NP's) was found to be 114±36nm using Scanning Electron Microscopy (SEM) and a significant increase in the hydrodynamic diameter of CuO NP was seen within 1h of interaction. The median lethal concentration (LC50) values obtained from the acute toxicity studies on different life stages of Artemia salina was found to be 61...
March 22, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28448505/polyphenolic-extract-of-insp-5-ptase-expressing-tomato-plants-reduce-the-proliferation-of-mcf-7-breast-cancer-cells
#14
Mohammad Alimohammadi, Mohamed Hassen Lahiani, Diamond McGehee, Mariya Khodakovskaya
In recent years, by extensive achievements in understanding the mechanisms and the pathways affected by cancer, the focus of cancer research is shifting from developing new chemotherapy methods to using natural compounds with therapeutic properties to reduce the adverse effects of synthetic drugs on human health. We used fruit extracts from previously generated human type I InsP 5-ptase gene expressing transgenic tomato plants for assessment of the anti-cancer activity of established genetically modified tomato lines...
2017: PloS One
https://www.readbyqxmd.com/read/28445992/interaction-between-the-estrogen-receptor-and-fibroblast-growth-factor-receptor-pathways-in-non-small-cell-lung-cancer
#15
Jill M Siegfried, Mariya Farooqui, Natalie J Rothenberger, Sanja Dacic, Laura P Stabile
The estrogen receptor (ER) promotes non-small cell lung cancer (NSCLC) proliferation. Since fibroblast growth factors (FGFs) are known regulators of stem cell markers in ER positive breast cancer, we investigated whether a link between the ER, FGFs, and stem cell markers exists in NSCLC. In lung preneoplasias and adenomas of tobacco carcinogen exposed mice, the anti-estrogen fulvestrant and/or the aromatase inhibitor anastrozole blocked FGF2 and FGF9 secretion, and reduced expression of the stem cell markers SOX2 and nanog...
April 11, 2017: Oncotarget
https://www.readbyqxmd.com/read/28442878/loose-anchoring-of-anagen-hairs-and-pili-torti-due-to-erlotinib
#16
Rodrigo Pirmez, Juan Piñeiro-Maceira, Carmen Gloria Gonzalez, Mariya Miteva
Erlotinib is a selective epidermal growth factor receptor inhibitor utilized in the treatment of solid tumors. Cutaneous side effects, including changes in hair texture and alopecia, have been described. In this case report, we describe two patients with a new finding of loose anagen hairs and pili torti leading to nonscarring marginal and diffuse alopecia and discuss potential mechanisms underlying erlotinib-induced hair changes.
October 2016: International Journal of Trichology
https://www.readbyqxmd.com/read/28427090/the-aldosterone-synthase-inhibitor-fad286-is-suitable-for-lowering-aldosterone-levels-in-zdf-rats-but-not-in-db-db-mice
#17
Anja Hofmann, Coy Brunssen, Mirko Peitzsch, Mariya Balyura, Jennifer Mittag, Annika Frenzel, Anett Jannasch, Nicholas F Brown, Steven M Weldon, Kristina K Gueneva-Boucheva, Graeme Eisenhofer, Stefan R Bornstein, Henning Morawietz
Inhibition of aldosterone synthase is an alternative treatment option to mineralocorticoid receptor antagonism to prevent harmful aldosterone actions. FAD286 is one of the best characterized aldosterone synthase inhibitors to date. FAD286 improves glucose tolerance and increases glucose-stimulated insulin secretion in obese and diabetic ZDF rats. However, there is limited knowledge about the dose-dependent effects of FAD286 on plasma aldosterone, corticosterone, and 11-deoxycorticosterone in ZDF rats and in db/db mice, a second important rodent model of obesity and type 2 diabetes...
April 20, 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28422545/response-to-aslankurt-et-al-re-safety-profile-of-stromal-hydration-of-clear-corneal-incisions-with-cefuroxime-in-the-mouse-model
#18
Mariya Moosajee, Veronica Ferguson
No abstract text is available yet for this article.
April 19, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28415561/phosphorylation-of-hsf1-at-serine-326-residue-is-related-to-the-maintenance-of-gynecologic-cancer-stem-cells-through-expression-of-hsp27
#19
Kazuyo Yasuda, Yoshihiko Hirohashi, Tasuku Mariya, Aiko Murai, Yuta Tabuchi, Takafumi Kuroda, Hiroki Kusumoto, Akari Takaya, Eri Yamamoto, Terufumi Kubo, Munehide Nakatsugawa, Takayuki Kanaseki, Tomohide Tsukahara, Yasuaki Tamura, Hiroshi Hirano, Tadashi Hasegawa, Tsuyoshi Saito, Noriyuki Sato, Toshihiko Torigoe
Cancer stem-like cells (CSCs)/ cancer-initiating cells (CICs) are defined by their higher tumor-initiating ability, self-renewal capacity and differentiation capacity. CSCs/CICs are resistant to several therapies including chemotherapy and radiotherapy. CSCs/CICs thus are thought to be responsible for recurrence and distant metastasis, and elucidation of the molecular mechanisms of CSCs/CICs are essential to design CSC/CIC-targeting therapy. In this study, we analyzed the molecular aspects of gynecological CSCs/CICs...
May 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28413900/efficacy-of-cognitive-behavioral-therapy-with-and-without-medication-for-adults-with-adhd
#20
Mariya V Cherkasova, Lisa R French, Cassidy A Syer, Lorne Cousins, Harry Galina, Yasaman Ahmadi-Kashani, Lily Hechtman
OBJECTIVE: Recent trials have demonstrated efficacy of cognitive behavioral therapy (CBT) in medicated adults with ADHD. Efficacy of CBT in unmedicated versus medicated adults remains mostly unknown. We evaluated the effects of group CBT alone versus combined with medication on ADHD symptoms and functional outcomes in adult patients. METHOD: Eighty-eight adults with ADHD received 12 manualized group CBT sessions, accompanied by individual coaching, either without ( n = 46) or with ( n = 42) medication...
October 1, 2016: Journal of Attention Disorders
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