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https://www.readbyqxmd.com/read/29043882/ovarian-volume-and-pcos-a-controversial-issue
#1
Pierluigi Giampaolino, Luigi Della Corte, Nicoletta De Rosa, Antonio Mercorio, Dario Bruzzese, Giuseppe Bifulco
Polycystic ovarian syndrome (PCOS) is a common endocrinopathy. The Rotterdam criteria indicate four distinct phenotypes. In phenotypes with the typical ovarian morphology (ovarian volume ≥10 ml) the sensibility to clomiphene citrate (CC) ovulation therapy was demonstrated inversely proportional to the ovarian volume. In this retrospective study we evaluated the influence of ovarian volume on the success rate of CC ovulation induction in women with anovulatory phenotype 2 characterized only by the presence of hyperandrogenism and anovulation (ANOV + HA)...
October 18, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29043706/the-effects-of-exercise-on-expression-of-cyp19-and-star-mrna-in-steroid-induced-polycystic-ovaries-of-female-rats
#2
Fatemeh Aghaie, Homayoun Khazali, Mehdi Hedayati, Ali Akbarnejad
Background: Polycystic ovarian syndrome (PCOS) is the most frequent female endocrine disorder that affects 5-10% of women. PCOS is characterized by hyperandrogenism, oligo-/anovulation, and polycystic ovaries. The aim of the present research is to evaluate the expression of steroidogenic acute regulatory protein (StAR) and aromatase (CYP19) mRNA in the ovaries of an estradiol valerate (EV)-induced PCOS rat model, and the effect of treadmill and running wheel (voluntary) exercise on these parameters...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29039176/-research-progress-on-the-relationship-of-brown-adipose-tissue-with-polycystic-ovary-syndrome
#3
Xiaohua Fu, Weihai Xu, Shengchun Qiu, Jing Shu
Brown adipose tissue (BAT) holds great promise for the prevention and treatment of metabolism diseases through thermoregulation. Polycystic ovary syndrome (PCOS) is a complex condition with anovulation, hyperandrogenism, and polycystic ovaries, and also manifests glucolipid metabolic disorders. Recent researches have shown that transplantation of BAT into a PCOS rat could significantly alleviate the phenotypes. This article reviews the role of BAT in pathogenesis of PCOS, which may provide information for prevention and treatment of PCOS...
May 25, 2017: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/29017868/rates-of-anovulation-in-adolescents-and-young-adults-with-moderate-to-severe-primary-dysmenorrhea-and-those-without-primary-dysmenorrhea
#4
Laura C Seidman, Kathleen M Brennan, Andrea J Rapkin, Laura A Payne
OBJECTIVE: To evaluate rates of presumptive anovulation in eumenorrheic adolescents and young adults with moderate to severe primary dysmenorrhea and those without primary dysmenorrhea. PARTICIPANTS: Thirty-nine adolescents and young adults (ages 16-24) with primary dysmenorrhea and 52 age-matched controls. DESIGN: Participants completed luteinizing hormone surge ovulation predictor test kits. Anovulatory cycles were defined by never receiving a positive result prior to the next menstrual period; participants were grouped as anovulatory if they experienced at least one anovulatory cycle during study participation...
October 7, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28990055/defective-insulin-signaling-and-the-protective-effects-of-dimethyldiguanide-during-follicular-development-in-the-ovaries-of-polycystic-ovary-syndrome
#5
Fan Wang, Shaobing Wang, Zhenghong Zhang, Qingqiang Lin, Yiping Liu, Yijun Xiao, Kaizhuan Xiao, Zhengchao Wang
It is established that the physiological effects of insulin are primarily mediated by the insulin signaling pathway. However, a defective insulin signaling is closely associated with the clinical manifestations of polycystic ovary syndrome (PCOS), which include excess androgen levels, insulin resistance and anovulation, and is involved in the pathophysiology of PCOS at the molecular level. Dimethyldiguanide (DMBG) has been widely employed to alleviate reproduction dysfunction in women with PCOS, however, the exact mechanism of this effect remains unclear...
September 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28973719/identification-of-differentially-expressed-genes-in-pathways-of-cerebral-neurotransmission-of-anovulatory-mice
#6
M A Azevedo, I D C G Silva
Polycystic ovary syndrome is the classic example of loss of functional cyclicity and anomalous feedback. In this case, the excessive extra-glandular production and conversion of androgens to estrogens are the pathophysiological basis of the chronic anovulation. The literature describes an experimental model of the polymicrocystic ovary in obese diabetic mice with insulin resistance. The fact that these animals exhibit obesity, insulin resistance, and infertility demonstrates their skill as an experimental model for polycystic ovary...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28961951/the-polycystic-ovary-syndrome-associated-gene-yap1-is-regulated-by-gonadotropins-and-sex-steroid-hormones-in-hyperandrogenism-induced-oligo-ovulation-in-mouse
#7
Shu-Yan Ji, Xiao-Man Liu, Bo-Tai Li, Yin-Li Zhang, Hong-Bin Liu, Yu-Chao Zhang, Zi-Jiang Chen, Junping Liu, Heng-Yu Fan
STUDY QUESTION: What is the physiological function of Yes-associated protein-1 (Yap1), a susceptibility gene for polycystic ovarian syndrome (PCOS), in ovarian granulosa cells? SUMMARY ANSWER: Physiologically, steroid sex hormones stimulate follicle growth by activating YAP1; however, the preovulatory inhibition of YAP1 activity in granulosa cells is a prerequisite of LH actions. WHAT IS KNOWN ALREADY: PCOS is a common gynecologic and endocrine disease with multiple short and long-term consequences...
August 10, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28951977/polycystic-ovary-syndrome-throughout-a-woman-s-life
#8
REVIEW
José Bellver, Luis Rodríguez-Tabernero, Ana Robles, Elkin Muñoz, Francisca Martínez, José Landeras, Juan García-Velasco, Juan Fontes, Mónica Álvarez, Claudio Álvarez, Belén Acevedo
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among reproductive-aged women and the main cause of infertility due to anovulation. However, this syndrome spans the lives of women affecting them from in-utero life until death, leading to several health risks that can impair quality of life and increase morbidity and mortality rates. Fetal programming may represent the beginning of the condition characterized by hyperandrogenism and insulin resistance which leads to a series of medical consequences in adolescence, adulthood, and old age...
September 27, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28944709/the-cardiometabolic-effect-of-current-management-of-polycystic-ovary-syndrome-strategies-of-prevention-and-treatment
#9
Dinka Pavicic Baldani, Lana Skrgatic, Roya Ougouag, Miro Kasum
Polycystic ovary syndrome (PCOS) is the commonest endocrine disorder amongst women of reproductive age, which is characterized by reproductive and cardiometabolic disturbances with long-term health repercussions. Insulin resistance (IR), impaired glucose tolerance, type 2 diabetes mellitus (DM2), obesity and dyslipidemia occur more in women with PCOS than in age-comparable women without PCOS. Long term data regarding risks or benefits of medical intervention for metabolic dysfunction of PCOS are lacking. Therapies, such as oral contraceptives (OCPs) and anti-androgenic medications used to manage the reproductive manifestations of PCOS, may themselves be the cause of cardiometabolic perturbations...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28944702/relationship-between-serum-anti-mullerian-hormone-and-intrafollicular-amh-levels-in-pcos-women
#10
M Stracquadanio, L Ciotta, M A Palumbo
Polycystic ovary syndrome is a complex disease characterized by various endocrine disorders that are the potential cause of anovulation and hyperandrogenism. Anti-Müllerian hormone expression is suspected to be overexpressed in PCOS granulosa cells. AMH acts as a regulator of folliculogenesis: it is produced by the granulosa cells of follicles from the stage of the primary follicle to the initial formation of the antrum. Serum and intrafollicular AMH levels are elevated in patients with PCOS due to increased number of small follicles and an increased secretion within each of these small follicles...
September 23, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28942551/androgen-excess-and-metabolic-disorders-in-women-with-pcos-beyond-the-body-mass-index
#11
REVIEW
R A Condorelli, A E Calogero, M Di Mauro, L M Mongioi', R Cannarella, G Rosta, S La Vignera
BACKGROUND: Insulin resistance is a common feature among women with polycystic ovary syndrome (PCOS), especially in those patients with hyperandrogenism and chronic anovulation. PCOS women are at risk for developing metabolic syndrome, impaired glucose tolerance and type II diabetes mellitus (DM II). OBJECTIVE: The aim of this review is to explore the existing knowledge of the interplay between androgen excess, pancreatic β-cell function, non-alcoholic fatty liver disease (NAFLD), intra-abdominal and subcutaneous (SC) abdominal adipocytes in PCOS, providing a better comprehension of the molecular mechanisms of diabetologic interest...
September 23, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28929646/-research-progress-in-mechanism-of-traditional-chinese-medicine-treatment-of-polycystic-ovary-syndrome
#12
REVIEW
Xian-Ying Zhou, Li Zhou, Zu-Yue Sun
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder, which is characterized by hyperandrogenism, insulin resistance and chronic anovulation, and has become a serious threat to the health of adolescents and women of childbearing age.At present,lowering androgen, improving insulin resistance and inducing ovulation are the main methods adopted by doctors to treat the disease, but the adverse reactions of the western medicine and the long-term treatment are hard to be accepted by the patients...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28915843/protective-effects-of-gaba-against-metabolic-and-reproductive-disturbances-in-letrozole-induced-polycystic-ovarian-syndrome-in-rats
#13
Asad Ullah, Sarwat Jahan, Suhail Razak, Madeeha Pirzada, Hizb Ullah, Ali Almajwal, Naveed Rauf, Tayyaba Afsar
BACKGROUND: PCOs is a heterogeneous disorder with anovulation/oligo ovulation usually taken as oligo menorrhoea or amenorrhoea, hyperandrogenemia, hirsutism, acne, androgen alopecia and polycystic ovaries as the key diagnostic feathers. The study was undertaken to investigate the possible protective and ameliorating effects of GABA in Letrozole induced PCOS model in rats by targeting insulin resistance. METHODS: PCOs in Adult female rat was induced by the daily gastric administration of letrozole (1 mg/kg/day) in CMC (0...
September 15, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28911175/hyperandrogenemia-induced-by-letrozole-treatment-of-pubertal-female-mice-results-in-hyperinsulinemia-prior-to-weight-gain-and-insulin-resistance
#14
Danalea V Skarra, Angelina Hernández-Carretero, Alissa J Rivera, Arya R Anvar, Varykina G Thackray
Women with polycystic ovary syndrome (PCOS) diagnosed with hyperandrogenism and ovulatory dysfunction have an increased risk of developing metabolic disorders, including type 2 diabetes and cardiovascular disease. We previously developed a model that uses letrozole to elevate endogenous testosterone levels in female mice. This model has hallmarks of PCOS, including hyperandrogenism, anovulation, and polycystic ovaries, as well as increased abdominal adiposity and glucose intolerance. In the current study, we further characterized the metabolic dysfunction that occurs after letrozole treatment to determine whether this model represents a PCOS-like metabolic phenotype...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28892255/does-cardiovascular-risk-vary-according-to-the-criteria-for-a-diagnosis-of-polycystic-ovary-syndrome
#15
Sedef Ramoglu, Tevfik Yoldemir, Kemal Atasayan, Dilek Gogas Yavuz
AIM: The risk of cardiovascular disease is higher in women with polycystic ovary syndrome (PCOS) compared to healthy individuals. Chronic inflammation, insulin resistance, hyperandrogenemia, hyperlipidemia and increased oxidative stress are known to have a role in the formation of atherosclerosis and cardiovascular disease. The aim of our study was to evaluate if cardiovascular risk varied according to different PCOS criteria, using carotid intima-media thickness (CIMT), which is an important marker of major cardiovascular events in the later stages of life...
September 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28868839/effect-of-grape-seed-extract-on-lipid-profile-and-expression-of-interleukin-6-in-polycystic-ovarian-syndrome-wistar-rat-model
#16
Zohreh Salmabadi, Homa Mohseni Kouchesfahani, Kazem Parivar, Latifeh Karimzadeh
Background: Polycystic ovary syndrome (PCOS) is a common but complex endocrine disorder and is the major cause of anovulation and consequent subfertility. In this study the effect of grape seed extract (GSE) on triglyceride (TG), total cholesterol (TC), highdensity lipoprotein-cholestrol (HDL-C), low-density lipoprotein-cholestrol (LDL-C) and interleukin-6 (IL-6) in PCOS Wistar rats were assessed. MATERIALS AND METHODS: In this experimental study, 84 adult female Wistar rats were divided into 7 groups (n=12) including control (intact), Sham (estradiol valerate solvent injection), control PCOS and 4 experimental PCOS groups...
October 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28867888/efficacy-of-combined-cabergoline-and-metformin-compared-to-metformin-alone-on-cycle-regularity-in-patients-with-polycystic-ovarian-disease-with-hyperprolactinemia-a-randomized-clinical-trial
#17
Mervat Ali Mohamed Elsersy
PURPOSE: Polycystic ovarian syndrome (PCOS) is a common reproductive disorder. Increasing serum prolactin in these patients could be detected in both follicular and luteal phase of the normal and stimulated cycles. Hyperprolactinemia affects the hypothalamic-pituitary-ovarian axis causing anovulation and abnormal uterine bleeding. In this study, the efficacy of combined cabergoline and metformin therapy was compared to metformin therapy alone in patients with PCOS on the body mass index, androgen profile and menstrual cycle regulation...
October 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28867510/role-of-metformin-for-ovulation-induction-in-infertile-patients-with-polycystic-ovary-syndrome-pcos-a-guideline
#18
(no author information available yet)
Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate (CC) or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS. There is fair evidence that metformin alone does not increase rates of miscarriage when stopped at the initiation of pregnancy and insufficient evidence that metformin in combination with other agents used to induce ovulation increases live-birth rates...
August 10, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28865539/role-of-metformin-for-ovulation-induction-in-infertile-patients-with-polycystic-ovary-syndrome-pcos-a-guideline
#19
REVIEW
(no author information available yet)
Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS. There is fair evidence that metformin alone does not increase rates of miscarriage when stopped at the initiation of pregnancy and insufficient evidence that metformin in combination with other agents used to induce ovulation increases live-birth rates...
September 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28854589/use-of-the-serum-anti-m%C3%A3-llerian-hormone-assay-as-a-surrogate-for-polycystic-ovarian-morphology-impact-on-diagnosis-and-phenotypic-classification-of-polycystic-ovary-syndrome
#20
Alice Fraissinet, Geoffroy Robin, Pascal Pigny, Tiphaine Lefebvre, Sophie Catteau-Jonard, Didier Dewailly
STUDY QUESTION: Does the use of the serum anti-Müllerian hormone (AMH) assay to replace or complement ultrasound (U/S) affect the diagnosis or phenotypic distribution of polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Combining U/S and the serum AMH assay to define polycystic ovarian morphology (PCOM) diagnoses PCOS (according to the Rotterdam classification) in more patients than definitions using one or the other of these indicators exclusively. WHAT IS KNOWN ALREADY: Since 2003, PCOM, as defined by U/S, is one of the three diagnostic criteria for PCOS...
August 1, 2017: Human Reproduction
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