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https://www.readbyqxmd.com/read/29775916/cortisol-trajectory-melancholia-and-response-to-electroconvulsive-therapy
#1
Brian J Mickey, Yarden Ginsburg, Adam F Sitzmann, Clara Grayhack, Srijan Sen, Clemens Kirschbaum, Daniel F Maixner, James L Abelson
While biomarkers have been used to define pathophysiological types and to optimize treatment in many areas of medicine, in psychiatry such biomarkers remain elusive. Based on previously described abnormalities of hypothalamic-pituitary-adrenal (HPA) axis function in severe forms of depression, we hypothesized that the temporal trajectory of basal cortisol levels would vary among individuals with depression due to heterogeneity in pathophysiology, and that cortisol trajectories that reflect elevated or increasing HPA activity would predict better response to electroconvulsive therapy (ECT)...
May 15, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29775234/effects-of-whole-body-vibration-on-heart-rate-variability-acute-responses-and-training-adaptations
#2
REVIEW
Alexei Wong, Arturo Figueroa
Heart rate variability (HRV) is a noninvasive and practical measure of cardiac autonomic nervous system function, mainly the sympathetic and parasympathetic modulations of heart rate. A low HRV has been shown to be indicative of compromised cardiovascular health. Interventions that enhance HRV are therefore beneficial to cardiovascular health. Whole-body vibration (WBV) training has been proposed as an alternative time-efficient exercise intervention for the improvement of cardiovascular health. In this review, we discuss the effect of WBV both acute and after training on HRV...
May 18, 2018: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/29775005/-determination-and-significance-of-serum-mpo-and-amylin-in-adult-patients-with-osahs-after-short-range-noninvasive-positive-pressure-ventilation
#3
X H Chen, P J Chen, Y Long, Q P Huang
Objective: The aim of this study to investigate the determination and significance of serum MPO and amylin in adult patients with OSAHS after short-range noninvasive positive pressure ventilation. Method: Eighty-seven OSAHS patients were divided into severe group (30 cases), moderate group (30 cases) and mild group (27 cases) according to the AHI range. Twenty-seven outpatient health persons were selected as the control group. Serum amylin and myeloperoxidase were measured by ELISA; Amyloid and myeloperoxidase were reassessed in 30 patients with severe OSAHS after 6 months of combined therapy, and the relationship between amylin, myeloperoxidase and PSG was analyzed...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29775000/-the-treatment-efficiency-of-a-new-ear-moding-device-in-the-infants-with-congenital-ear-abnormalities
#4
P W Chen, J Li, S Q Zhao, J S Yang, J M Dou, C Y Wei
Objective: To observe the nonsurgical treatment effciency of a new ear moding device on congenital auricle deformities in order to promote clinical application. Method: Twenty-nine patients (38 ears) from Beijing Tongren Hospital Outpatient received ear molding treatment using the EarWell Infant Ear Correction System. We keep regular follow-up and close observation during the moding period. The treatment effciency was judged by the otologist, plastic surgeons and parents based on the preprocedure and postprocedure photographs and divided into 3 grades: excellent, good and poor...
June 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29774779/image-guided-radiation-therapy-for-post-operative-gynaecologic-cancer-patient-set-up-verification-with-and-without-implanted-fiducial-markers
#5
Donna H Murrell, Andrew Warner, Quinn Benwell, Wendy Wells, Danielle Scott, Vikram Velker, George Hajdok, David P D'Souza
BACKGROUND: Intensity modulated radiotherapy (IMRT) is increasingly being used to treat gynaecological malignancies in the postoperative setting. The purpose of this study was to evaluate the use of image-guided radiotherapy (IGRT) using cone-beam computed tomography (CBCT) with fiducial markers for daily localization. MATERIAL AND METHODS: A single institution study was performed of consecutive cervical or endometrial cancer patients receiving adjuvant external beam radiotherapy (n = 15)...
May 18, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29774076/the-human-somatostatin-receptor-type-2-as-an-imaging-and-suicide-reporter-gene-for-pluripotent-stem-cell-derived-therapy-of-myocardial-infarction
#6
Katrien Neyrinck, Natacha Breuls, Bryan Holvoet, Wouter Oosterlinck, Esther Wolfs, Hubert Vanbilloen, Olivier Gheysens, Robin Duelen, Willy Gsell, Ivo Lambrichts, Uwe Himmelreich, Catherine M Verfaillie, Maurilio Sampaolesi, Christophe M Deroose
Rationale: Pluripotent stem cells (PSCs) are being investigated as a cell source for regenerative medicine since they provide an infinitive pool of cells that are able to differentiate towards every cell type of the body. One possible therapeutic application involves the use of these cells to treat myocardial infarction (MI), a condition where billions of cardiomyocytes (CMs) are lost. Although several protocols have been developed to differentiate PSCs towards CMs, none of these provide a completely pure population, thereby still posing a risk for neoplastic teratoma formation...
2018: Theranostics
https://www.readbyqxmd.com/read/29773860/noninvasive-low-cycle-fatigue-characterization-at-high-depth-with-photoacoustic-eigen-spectrum-analysis
#7
Xiaoxiang Gao, Chao Tao, Rong Zhu, Xiaojun Liu
In this work, photoacoustic eigen-spectrum analysis was proposed for noninvasively characterizing the mechanical properties of materials. We theoretically predicted the relationship between the photoacoustic eigen-spectra of cylindrical optical absorbers and their mechanical properties. Experimental measurements of eigen-spectra extracted from photoacoustic coda waves agreed well with the theoretical predictions. We then applied the photoacoustic eigen-spectrum analysis for contactless monitoring of low-cycle fatigue damage...
May 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773297/the-clinical-practice-of-high-flow-nasal-cannula-oxygen-therapy-in-adults-a-japanese-cross-sectional-multicenter-survey
#8
Jiro Ito, Kazuma Nagata, Susumu Sato, Akira Shiraki, Naoki Nishimura, Shinyu Izumi, Ryo Tachikawa, Takeshi Morimoto, Keisuke Tomii
BACKGROUND: High-flow nasal cannula oxygen therapy (HFNC) is widely used mainly in the acute care setting, but limited data are available on real-world practice in adults. The objective of this study was to describe HFNC practices in Japanese adults. METHODS: A retrospective cross-sectional multicenter survey of adult patients receiving HFNC from January through March 2015 was conducted in 33 participating hospitals in Japan. RESULTS: We obtained information on 321 patients (median age, 76; 218 men, 103 women; median estimated PaO2 /FI O2, 178 mm Hg) from 22 hospitals...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773292/health-related-quality-of-life-measurement-in-patients-with-chronic-respiratory-failure
#9
REVIEW
Toru Oga, Wolfram Windisch, Tomohiro Handa, Toyohiro Hirai, Kazuo Chin
The improvement of health-related quality of life (HRQL) is an important goal in managing patients with chronic respiratory failure (CRF) receiving long-term oxygen therapy (LTOT) and/or domiciliary noninvasive ventilation (NIV). Two condition-specific HRQL questionnaires have been developed to specifically assess these patients: the Maugeri Respiratory Failure Questionnaire (MRF) and the Severe Respiratory Insufficiency Questionnaire (SRI). The MRF is more advantageous in its ease of completion; conversely, the SRI measures diversified health impairments more multi-dimensionally and discriminatively with greater balance, especially in patients receiving NIV...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773291/cost-utility-of-non-invasive-mechanical-ventilation-analysis-and-implications-in-acute-respiratory-failure-a-brief-narrative-review
#10
REVIEW
Antonello Nicolini, Sven Stieglitz, Pierre Bou-Khalil, Antonio Esquinas
The growing interest in the quality of patient care at the levels of the health care managers, insurance companies, and health professionals is evident. Further, the growing population requires good quality health services. In this review, we analyzed the cost-effectiveness of noninvasive ventilation (NIV) in an acute setting for the treatment of respiratory failure. The strength of this review is that it identified and summarized the most relevant studies regarding various aspects of the cost-utility of NIV in an acute setting...
May 2018: Respiratory Investigation
https://www.readbyqxmd.com/read/29773202/impaired-short-term-plasticity-in-restless-legs-syndrome-a-pilot-rtms-study
#11
Giuseppe Lanza, Bartolo Lanuzza, Debora Aricò, Mariagiovanna Cantone, Filomena Irene Ilaria Cosentino, Rita Bella, Giovanni Pennisi, Raffaele Ferri, Manuela Pennisi
BACKGROUND: Previous studies showed an impairment of the LTP-like plasticity to TMS in restless legs syndrome (RLS). Clinically, repetitive TMS (rTMS) was effective in alleviating the sensory-motor complaints of patients, although the effects induced by low-frequency (inhibitory) rTMS have not yet been investigated. An impaired LTD-like mechanism of cortical plasticity has been hypothesized, which we have directly assessed in this pilot study. METHODS: Motor evoked potentials (MEPs) from the right first dorsal interosseus muscle were recorded at the stimulus intensity of 110% of the resting motor threshold (rMT) from 13 right-handed patients and ten age-matched right-handed healthy controls...
June 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29772963/simplifying-skin-disease-diagnosis-with-topical-nanotechnology
#12
David C Yeo, Chenjie Xu
A new study published in the journal Nature Biomedical Engineering1 documents a novel diagnostic technology that exploits topically applied nanotechnology to detect skin tissue biomarkers for diagnosis. This concept is demonstrated by noninvasively imaging connective tissue growth factor (CTGF) mRNA in abnormal scar cells, whole tissue, and animal models. In this commentary, we highlight the main findings and discuss their implications. Successful implementation in the clinic could give rise to self-applied, biopsy-free diagnostic technology and significantly reduce healthcare burden...
May 1, 2018: SLAS Technology
https://www.readbyqxmd.com/read/29771696/the-future-of-anesthesia-for-interventional-radiology
#13
Annie Amin, Jason Scott Lane
PURPOSE OF REVIEW: To review novel procedures in interventional radiology and describe anesthetic implications. RECENT FINDINGS: Noninvasive treatment options for patients who are nonsurgical candidates are on the rise. The complication rate for patients receiving anesthesia in the interventional radiology suite is higher than other nonoperating room anesthetizing locations. The investigative use of catheter-directed thrombolysis for acute submassive pulmonary embolism will likely lead to an increased demand for anesthesia assistance...
May 15, 2018: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/29771297/measurement-of-protein-digestibility-in-humans-by-a-dual-tracer-method
#14
Sarita Devi, Aneesia Varkey, M S Sheshshayee, Thomas Preston, Anura V Kurpad
Background: Recent evaluations of the risk of dietary protein deficiency have indicated that protein digestibility may be a key limiting factor in the provision of indispensable amino acids (IAAs), particularly for vulnerable populations living in challenging environments where intestinal dysfunction may exist. Since the digestion of protein occurs only in the small intestine, and the metabolic activity of colonic bacteria confounds measurements at the fecal level, there is a need to develop noninvasive protein digestibility measurements at the ileal level...
May 15, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29770763/a-radiomics-nomogram-for-preoperative-prediction-of-microvascular-invasion-risk-in-hepatitis-b-virus-related-hepatocellular-carcinoma
#15
Jie Peng, Jing Zhang, Qifan Zhang, Yikai Xu, Jie Zhou, Li Liu
PURPOSE: We aimed to develop and validate a radiomics nomogram for preoperative prediction of microvascular invasion (MVI) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). METHODS: A total of 304 eligible patients with HCC were randomly divided into training (n=184) and independent validation (n=120) cohorts. Portal venous and arterial phase computed tomography data of the HCCs were collected to extract radiomic features. Using the least absolute shrinkage and selection operator algorithm, the training set was processed to reduce data dimensions, feature selection, and construction of a radiomics signature...
May 2018: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/29770573/looking-into-the-eye-of-patients-with-chronic-obstructive-pulmonary-disease-an-opportunity-for-better-microvascular-profiling-of-these-complex-patients
#16
REVIEW
Anouk W Vaes, Martijn A Spruit, Jan Theunis, Nandu Goswami, Lowie E Vanfleteren, Frits M E Franssen, Emiel F M Wouters, Patrick De Boever
Chronic obstructive pulmonary disease (COPD) is a complex disease with many patients suffering from cardiovascular comorbidity. However, cardiovascular diseases remain often undiagnosed in COPD. Assessment of the retinal microvasculature can provide value in cardiovascular profiling of these patients. Retinal microvascular assessment carried out via a noninvasive eye exam represents an easy to use tool when examining patients with COPD. The purpose of this review was to provide an overview of studies assessing structural and functional changes in the retinal microvasculature of patients with COPD...
May 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29770267/role-of-noninvasive-imaging-of-cerebral-arterial-system-in-ischemic-stroke-comparison-of-transcranial-color-coded-doppler-sonography-with-magnetic-resonance-angiography
#17
Betty Simon, Sunithi Elizabeth Mani, Shyamkumar Nidugala Keshava, Mathew Alexander, Sanjith Aaron
Aim: To determine the accuracy of transcranial color-coded Doppler sonography (TCCS) in the evaluation of cerebral arterial system in patients with ischemic stroke attending a tertiary care hospital in South India. Objectives: (1) To describe the topographical distribution of atherosclerotic lesions in the cerebral circulation in patients presenting with ischemic stroke from the Indian subcontinent and (2) to determine the accuracy of TCCS for detection and quantification of intracranial stenoses in various segments of the intracerebral arterial system in comparison with magnetic resonance angiography (MRA)...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29769454/noninvasive-assessment-of-arterial-stiffness-using-oscillometric-methods-bapwv-cavi-api-and-avi
#18
Masaaki Miyata
No abstract text is available yet for this article.
May 16, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29769414/clinical-utility-of-arterial-spin-labeling-for-preoperative-grading-of-glioma-a-diagnostic-meta-analysis
#19
Linchen Li, Xinjun Wang, Min Zhang, Yan Zhang
There were obvious differences in biological behavior and prognosis between low-grade glioma and high-grade glioma, it is of great importance for clinicians to make a right judgement for preoperative grading. We conducted a comprehensive meta-analysis to evaluate the clinical utility of arterial spin labeling for preoperative grading. We searched the PubMed, Embase, China National Knowledge Infrastructure, and Weipu electronic databases for articles published through November 10, 2017 and used "arterial spin-labeling" OR "ASL perfusion, grading" OR "differentiation, glioma" OR "glial tumor, diagnostic test" as the search terms...
May 16, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29769376/-lactobacillus-mucosal-vaccine-vectors-immune-responses-against-bacterial-and-viral-antigens
#20
REVIEW
Jonathan S LeCureux, Gregg A Dean
Lactic acid bacteria (LAB) have been utilized since the 1990s for therapeutic heterologous gene expression. The ability of LAB to elicit an immune response against expressed foreign antigens has led to their exploration as potential mucosal vaccine candidates. LAB vaccine vectors offer many attractive advantages: simple, noninvasive administration (usually oral or intranasal), the acceptance and stability of genetic modifications, relatively low cost, and the highest level of safety possible. Experimentation using LAB of the genus Lactobacillus has become popular in recent years due to their ability to elicit strong systemic and mucosal immune responses...
June 27, 2018: MSphere
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