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https://www.readbyqxmd.com/read/28738322/pediatric-obstructive-sleep-apnea-where-do-we-stand
#1
Yu-Shu Huang, Christian Guilleminault
Pediatric obstructive sleep apnea (OSA) was initially described in 1976. In 1981, Dr. Guilleminault emphasized that pediatric OSA was different from the clinical presentation reported in adults. It was characterized by more disturbed nocturnal sleep than excessive daytime sleepiness, and presented more behavioral problems, particularly school problems, hyperactivity, nocturnal enuresis, sleep terrors, depression, insomnia, and psychiatric problems. The underlying causes of pediatric OSA are complex. Such factors as adenotonsillar hypertrophy, obesity, anatomical and neuromuscular factors, and hypotonic neuromuscular disease are also involved...
2017: Advances in Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28738134/indocyanine-green-angiography-and-optical-coherence-tomography-angiography-of-choroidal-neovascularization-in-age-related-macular-degeneration
#2
Chiara M Eandi, Antonio Ciardella, Mariacristina Parravano, Filippo Missiroli, Camilla Alovisi, Chiara Veronese, Maria C Morara, Massimo Grossi, Gianni Virgili, Federico Ricci
Purpose: To compare the capability of indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) in detecting choroidal neovascularization (CNV). Methods: In this prospective study, patients with CNV detected with fluorescein angiography (FA) underwent ICGA and OCTA, spectral domain OCT (SD-OCT), and infrared or fundus color photographs. CNV lesions were outlined on ICGA and OCTA images, and the composition and size of the CNV was documented...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28738077/consequences-of-severe-habitat-fragmentation-on-density-genetics-and-spatial-capture-recapture-analysis-of-a-small-bear-population
#3
Sean M Murphy, Ben C Augustine, Wade A Ulrey, Joseph M Guthrie, Brian K Scheick, J Walter McCown, John J Cox
Loss and fragmentation of natural habitats caused by human land uses have subdivided several formerly contiguous large carnivore populations into multiple small and often isolated subpopulations, which can reduce genetic variation and lead to precipitous population declines. Substantial habitat loss and fragmentation from urban development and agriculture expansion relegated the Highlands-Glades subpopulation (HGS) of Florida, USA, black bears (Ursus americanus floridanus) to prolonged isolation; increasing human land development is projected to cause ≥ 50% loss of remaining natural habitats occupied by the HGS in coming decades...
2017: PloS One
https://www.readbyqxmd.com/read/28737601/new-ways-to-detect-pediatric-sickle-cell-retinopathy-a-comprehensive-review
#4
Daniel A Pahl, Nancy S Green, Monica Bhatia, Royce W S Chen
Sickle retinopathy reflects disease-related vascular injury of the eye, which can potentially result in visual loss from vitreous hemorrhage or retinal detachment. Here we review sickle retinopathy among children with sickle cell disease, describe the epidemiology, pediatric risk factors, pathophysiology, ocular findings, and treatment. Newer, more sensitive ophthalmological imaging modalities are available for retinal imaging, including ultra-widefield fluorescein angiography, spectral-domain optical coherence tomography, and optical coherence tomography angiography...
July 21, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28737600/an-interprofessional-quality-improvement-initiative-to-standardize-pediatric-extubation-readiness-assessment
#5
Samer Abu-Sultaneh, Acrista J Hole, Alvaro J Tori, Brain D Benneyworth, Riad Lutfi, Christopher W Mastropietro
OBJECTIVES: Establishing protocols to wean mechanical ventilation and assess readiness for extubation, with the goal of minimizing morbidity associated with extubation failure and prolonged mechanical ventilation, have become increasingly important in contemporary PICUs. The aim of this quality improvement initiative is to establish a respiratory therapist-led daily spontaneous breathing trial protocol to standardize extubation readiness assessment and documentation in our PICU. DESIGN: A quality improvement project...
July 21, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28737423/mass-spectrometric-techniques-for-the-analysis-of-volatile-organic-compounds-emitted-from-bacteria
#6
Ileana-Andreea Ratiu, Tomasz Ligor, Victor Bocos-Bintintan, Bogusław Buszewski
Bacteria are the main cause of many human diseases. Typical bacterial identification methods, for example culture-based, serological and genetic methods, are time-consuming, delaying the potential for an early and accurate diagnosis and the appropriate subsequent treatment. Nevertheless, there is a stringent need for in situ tests that are rapid, noninvasive and sensitive, which will greatly facilitate timely treatment of the patients. This review article presents volatile organic metabolites emitted from various micro-organism strains responsible for common bacterial infections in humans...
July 24, 2017: Bioanalysis
https://www.readbyqxmd.com/read/28737272/dynamic-coupling-between-fmri-local-connectivity-and-interictal-eeg-in-focal-epilepsy-a-wavelet-analysis-approach
#7
Amir Omidvarnia, Mangor Pedersen, David N Vaughan, Jennifer M Walz, David F Abbott, Andrew Zalesky, Graeme D Jackson
Simultaneous scalp EEG-fMRI recording is a noninvasive neuroimaging technique for combining electrophysiological and hemodynamic aspects of brain function. Despite the time-varying nature of both measurements, their relationship is usually considered as time-invariant. The aim of this study was to detect direct associations between scalp-recorded EEG and regional changes of hemodynamic brain connectivity in focal epilepsy through a time-frequency paradigm. To do so, we developed a voxel-wise framework that analyses wavelet coherence between dynamic regional phase synchrony (DRePS, calculated from fMRI) and band amplitude fluctuation (BAF) of a target EEG electrode with dominant interictal epileptiform discharges (IEDs)...
July 24, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28737194/-face-protective-patches-do-not-reduce-facial-pressure-ulcers-in-a-simulated-model-of-non-invasive-ventilation
#8
Hugo Riquelme M, David Wood V, Santiago Martínez F, Fernando Carmona M, Axel Peña V, Adriana Wegner A
Noninvasive ventilation (NIV) frequently involves the development of facial pressure ulcers (FPU). Its prevention considers the empirical use of protective patches between skin and mask, in order to reduce the pressure exerted by it. OBJECTIVES: To evaluate the effect of protective patches on the pressure exerted by the facial mask, and its impact on the programmed ventilatory parameters. METHOD: Bilevel NIV simulated model using full face mask in phantom with a physiological airway (ALS PRO +) in supine position...
June 2017: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/28736987/cardiac-stress-mri-evaluation-of-anomalous-aortic-origin-of-a-coronary-artery
#9
Cory Noel
Myocardial ischemia is an insult that is primarily thought of in an adult population. However, there are several congenital and acquired cardiac lesions that may lead to myocardial ischemia in a pediatric population. One of the prominent congenital lesions is anomalous aortic origin of a coronary artery (AAOCA). Anomalous aortic origin of a coronary artery is one of the leading causes sudden cardiac death in pediatric and young adult patients, and thus the assessment of myocardial perfusion is of the utmost importance...
July 24, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28736906/dental-pulp-stem-cells-and-the-management-of-neurological-diseases-an-update
#10
REVIEW
Ibrahim Mortada, Rola Mortada, Mohamad Al Bazzal
Medical research in regenerative medicine has brought promising perspectives for the use of stem cells in clinical trials. Stem cells are undifferentiated cells capable of multilineage differentiation and available in numerous sources in the human body. Dental pulp constitutes an attractive source of these cells since collecting mesenchymal stem cells from this site is a noninvasive practice that can be performed after a common surgical extraction of supernumerary or wisdom teeth. Thus, tissue sacrifice is very low and several cytotypes can be obtained owing to these cells' multipotency, in addition to the fact that they can be cryopreserved and stored for long periods...
July 24, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28736684/multimodality-imaging-approaches-for-evaluating-traumatic-extremity-injuries-implications-for-military-medicine
#11
REVIEW
Mitchel R Stacy, Christopher L Dearth
Significance: Military service members are susceptible to traumatic extremity injuries that often result in limb loss. Tremendous efforts have been made to improve medical treatment that supports residual limb function and health. Despite recent improvements in treatment and novel prosthetic devices, many patients experience a wide range of clinical problems within residual limbs that can negatively impact the progress of rehabilitation programs while also impairing functional capacity and overall quality of life...
July 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28736682/standardized-approach-to-quantitatively-measure-residual-limb-skin-health-in-individuals-with-lower-limb-amputation
#12
Cameron L Rink, Matthew M Wernke, Heather M Powell, Mark Tornero, Surya C Gnyawali, Ryan M Schroeder, Jayne Y Kim, Jeffrey A Denune, Alexander W Albury, Gayle M Gordillo, James M Colvin, Chandan K Sen
Objective: (1) Develop a standardized approach to quantitatively measure residual limb skin health. (2) Report reference residual limb skin health values in people with transtibial and transfemoral amputation. Approach: Residual limb health outcomes in individuals with transtibial (n = 5) and transfemoral (n = 5) amputation were compared to able-limb controls (n = 4) using noninvasive imaging (hyperspectral imaging and laser speckle flowmetry) and probe-based approaches (laser doppler flowmetry, transcutaneous oxygen, transepidermal water loss, surface electrical capacitance)...
July 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28736671/noninvasive-in-vivo-monitoring-of-collagenase-induced-intracerebral-hemorrhage-by-photoacoustic-tomography
#13
Dan Wu, Jinge Yang, Guang Zhang, Huabei Jiang
Photoacoustic tomography (PAT) is an emerging noninvasive biomedical imaging modality that can be used for visualizing the structure and function of brain in high resolution. Here we report an application of PAT to imaging intracerebral hemorrhage (ICH) in a mouse model. In vivo photoacoustic images were obtained in mice with right basal ganglia hemorrhage induced by microinjection of collagenase. With multi-spectral light excitation, cortical vascular network was clearly revealed at 532 nm, and ICH associated hematoma lesions and perihemmatoma regions were accurately mapped over time at 750 nm and 875 nm, respectively...
April 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28736428/penile-doppler-ultrasonography-revisited
#14
Dae Chul Jung, Sung Yoon Park, Joo Yong Lee
Penile Doppler ultrasonography is a high-performing, noninvasive or minimally-invasive imaging modality that allows the depiction of the normal anatomy and macroscopic pathologic changes in real time. Moreover, functional changes in penile blood flow, as seen in erectile dysfunction (ED), can be analyzed using color Doppler ultrasonography (CDUS). This review article describes the normal sonographic anatomy of the penis, the sonographic technique for evaluating ED, the normal phases of erection, and the various causes of ED...
June 10, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28736323/offspring-neuroimmune-consequences-of-maternal-malnutrition-potential-mechanism-for-behavioral-impairments-that-underlie-metabolic-and-neurodevelopmental-disorders
#15
REVIEW
B L Smith, T M Reyes
Maternal malnutrition significantly increases offspring risk for both metabolic and neurodevelopmental disorders. Animal models of maternal malnutrition have identified behavioral changes in the adult offspring related to executive function and reward processing. Together, these changes in executive and reward-based behaviors likely contribute to the etiology of both metabolic and neurodevelopmental disorders associated with maternal malnutrition. Concomitant with the behavioral effects, maternal malnutrition alters offspring expression of reward-related molecules and inflammatory signals in brain pathways that control executive function and reward...
July 20, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28736023/protective-effects-of-geniposide-on-hepatic-ischemia-reperfusion-injury
#16
Y-P Rong, H-T Huang, J-S Liu, L Wei
BACKGROUND: Geniposide (GEN) is the major ingredient of Gardenia jasminoides Ellis, which has anti-inflammatory and anti-apoptotic activities and is widely used to treat ischemia disease. Inflammation and apoptosis play an important role in hepatic ischemia/reperfusion (I/R) injury. The current study was conducted to explore the effects of geniposide on hepatic I/R injury and its potential molecular mechanism in mice. METHODS: Fifty Sprague-Dawley rats were randomly divided into 5 groups: the sham group (sham), the hepatic I/R injury group (IRI) and the GEN groups (low, middle, and high)...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28736002/high-flow-nasal-cannula-versus-noninvasive-ventilation-for-treatment-of-acute-hypoxemic-respiratory-failure-in-renal-transplant-recipients
#17
G Tu, H He, K Yin, M Ju, Y Zheng, D Zhu, Z Luo
OBJECTIVE: This study aimed to evaluate the outcomes of high-flow nasal cannula (HFNC) oxygen therapy compared with noninvasive ventilation (NIV) for the treatment of acute hypoxemic respiratory failure in renal transplant recipients. METHODS: Data were retrospectively collected from a tertiary intensive care unit (ICU) from July 1, 2011, to September 31, 2015. All renal recipients who had acute respiratory failure at that period of time were classified into the HFNC or NIV group depending on the initial form of respiratory support...
July 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28734923/diagnostic-accuracy-of-coronary-ct-angiography-for%C3%A2-the-evaluation-of-bioresorbable-vascular-scaffolds
#18
Carlos Collet, Bernard Chevalier, Angel Cequier, Jean Fajadet, Marcello Dominici, Steffen Helqvist, A J Van Boven, Dariusz Dudek, Dougal McClean, Manuel Almeida, Jan J Piek, Erhan Tenekecioglu, Antonio Bartorelli, Stephan Windecker, Patrick W Serruys, Yoshinobu Onuma
OBJECTIVES: To assess the diagnostic accuracy of coronary computed tomography angiography (CTA) for bioresorbable vascular scaffold (BVS) evaluation. BACKGROUND: Coronary CTA has emerged as a noninvasive method to evaluate patients with suspected or established coronary artery disease. The diagnostic accuracy of coronary CTA to evaluate angiographic outcomes after BVS implantation has not been well established. METHODS: In the ABSORB II (A Bioresorbable Everolimus-Eluting Scaffold Versus a Metallic Everolimus-Eluting Stent II) study, patients were randomized either to receive treatment with the BVS or everolimus-eluting metallic stent...
July 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28734900/molecular-imaging-in-stem-cell-based-therapies-of-cardiac-diseases
#19
REVIEW
Xiang Li, Marcus Hacker
In the past 15years, despite regenerative medicine has shown great potential for cardiovascular diseases, the outcome and safety of stem cell transplantation has shown controversial results in the published literature. Medical imaging might be useful for monitoring and quantification transplanted cells within the heart and to serially characterize the effects of stem cell therapy of the myocardium. From the multiple available noninvasive imaging techniques, magnetic resonance imaging and nuclear imaging by positron (PET) or single photon emission computer tomography (SPECT) are the most used clinical approaches to follow the fate of transplanted stem cells in vivo...
July 19, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28734808/-congenital-cytomegalovirus-infection-manifesting-as-neonatal-respiratory-distress-in-an-hiv-exposed-uninfected-newborn
#20
A Pham, H El Mjati, N Nathan, F Kieffer, D Mitanchez
BACKGROUND: Cytomegalovirus (CMV) is one of the most common intrauterine infections, affecting approximately 1% of all live births. There are few reports on congenital CMV infections manifesting as isolated pneumonitis. CASE REPORT: We report a case of congenital CMV with neonatal respiratory distress affecting an HIV-exposed uninfected infant. This infant required noninvasive ventilation beginning within the first 15min of life. The initial chest X-ray showed diffuse bilateral ground-glass opacifications...
July 19, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
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