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Peyronies's Disease

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https://www.readbyqxmd.com/read/29333517/safety-and-feasibility-of-platelet-rich-fibrin-matrix-injections-for-treatment-of-common-urologic-conditions
#1
Ethan L Matz, Amy M Pearlman, Ryan P Terlecki
Purpose: Autologous platelet rich plasma (PRP) is used increasingly in a variety of settings. PRP injections have been used for decades to improve angiogenesis and wound healing. They have also been offered commercially in urology with little to no data on safety or efficacy. PRP could theoretically improve multiple urologic conditions, such as erectile dysfunction (ED), Peyronie's disease (PD), and stress urinary incontinence (SUI). A concern with PRP, however, is early washout, a situation potentially avoided by conversion to platelet rich fibrin matrix (PRFM)...
January 2018: Investigative and Clinical Urology
https://www.readbyqxmd.com/read/29325832/the-pics-technique-a-novel-approach-for-residual-curvature-correction-during-penile-prosthesis-implantation-in-patients-with-severe-peyronie-s-disease-using-the-collagen-fleece-tachosil
#2
Georgios Hatzichristodoulou
BACKGROUND: Correction of residual curvature during inflatable penile prosthesis (IPP) implantation in patients with Peyronie's disease (PD) by plaque incision and grafting is a common approach. AIM: To present a novel technique for residual curvature correction during IPP implantation using collagen fleece (TachoSil, Baxter Healthcare Corp, Deerfield, IL, USA). METHODS: After the IPP (Titan Touch, Coloplast, Minneapolis, MN, USA) is placed, the implant is inflated maximally...
January 8, 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29310171/re-clinical-experience-with-penile-traction-therapy-among-men-undergoing-collagenase-clostridium-histolyticum-for-peyronie-disease
#3
Allen F Morey
No abstract text is available yet for this article.
January 2018: Journal of Urology
https://www.readbyqxmd.com/read/29289534/penile-length-measurement-technique-and-applications
#4
Ethan P Davoudzadeh, Natan P Davoudzadeh, Ezra Margolin, Peter J Stahl, Doron S Stember
INTRODUCTION: Penile size has long been an important fixation in men's lives. On the one hand, a smaller penis has been associated with anxiety and apprehension; on the other hand, a larger penis has generally been related to virility and strength. These perceptions predominate during an erection, when penile size is representative of a man's masculinity. AIM: To assess adult penile length and summarize average penile length assessments from the literature; analyze how various urologic diseases and therapies affect penile length and volume; and review how surgical treatments for Peyronie's disease, penile prosthesis implantation, and radical prostatectomy can affect penile size to appropriately counsel patients seeking such therapies and set realistic goals for patients...
December 27, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/29275049/the-multiple-slit-technique-must-for-penile-length-and-girth-restoration
#5
Paulo H Egydio, Franklin E Kuehhas
BACKGROUND: Patients with severe erectile dysfunction (ED) and penile size issues, especially seen in Peyronie's disease (PD), are candidates for more invasive penile prosthesis insertion techniques that aim for penile length and girth reconstruction. AIM: To present the feasibility and safety of penile length and girth restoration based on the so-called multiple-slit technique (MUST) for patients with severe ED and significant penile shortening with or without PD...
December 20, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29242634/extracellular-matrix-alterations-after-blood-instillation-in-tunica-albuginea-of-rats
#6
David J Cohen, André V Oliveira, Théresè R Theodoro, Giuliana Petri, Carina M Melo, Renan P Cavalheiro, Helena B Nader, Ana M Mader, Maria A S Pinhal, Sidney Glina
The cause of Peyronie's disease (PD) is still not completely understood. The objective of this study, therefore, was to analyze the histological and biochemical alterations that occur after the instillation of blood in the tunica albuginea (TA) of rats with an emphasis on the remodeling process of ECM. Thirty male Wistar rats were divided into 4 groups: two control groups with instillation of distilled water in TA followed by penectomy after 15 days or 45 days, respectively and two experimental groups with instillation of blood in TA followed by penectomy after 15 days or 45 days, respectively...
December 15, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29239395/treatment-of-peyronie-s-disease-via-preoperative-intralesional-collagenase-clostridium-histolyticum-followed-by-placement-of-an-inflatable-penile-prosthesis-the-new-standard-of-care
#7
EDITORIAL
Jason Akerman, Jason R Kovac
No abstract text is available yet for this article.
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238669/use-of-amnion-chorion-and-umbilical-cord-grafts-in-conjunction-with-penile-implant-procedures
#8
Andrew C Kramer
Biologics have increased in popularity lately as a novel and exciting new therapy for men with a spectrum of sexual dysfunction ailments-ranging from erectile dysfunction, Peyronie's disease, and ejaculatory disorders. In this series, sequential patients were analyzed who received biologic materials at the time of their penile implant surgery, with various metrics assessed. The information gathered includes recovery time, need for postoperative analgesics, and satisfaction with the final outcome. In this study, early metrics appear to point to improved outcomes in select criteria...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29238661/penile-prosthetic-surgery-for-the-management-of-peyronie-s-disease
#9
REVIEW
Omer A Raheem, Tung-Chin Hsieh
With the increased prevalence of Peyronie's disease (PD) among men, there is also an up-rise of associated erectile dysfunction (ED) which can be devastating psychologically and sexually to most men. A wide range of therapies including medical and surgical procedures are available to satisfactorily address this condition. However when ED coexists, the gold standard treatment is penile prosthetic prosthesis (PP) with or without additional straightening procedures. We herein systematically review the contemporary literature addressing the role of the PP in the management of PD with concomitant ED with particular emphasis on patient's satisfaction, outcomes and safety...
November 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29211402/sonographic-patterns-of-peyronie-s-disease-in-patients-with-absence-of-palpable-plaques
#10
Lucio Dell'Atti, Andrea Benedetto Galosi
PURPOSE: Non-palpable isolated septal plaques of the penis are likely present in a significant number of patients affected by erectile dysfunction (ED) and penile pain without deformity or curvature. The aim of this study was to evaluate the ultrasound (US) patterns observed in patients investigated for ED or penile pain without curvature. MATERIALS AND METHODS: We reviewed the medical records of 386 patients who underwent an initial colour-Doppler ultrasonography (CDU) of the penis for DE and/or penile pain without curvature...
December 7, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/29205179/commentary-on-nondegloving-technique-for-peyronie-s-disease-with-penile-prosthesis-implantation-and-double-dorsal-ventral-patch-graft
#11
Gerard D Henry, Kavina Jani
No abstract text is available yet for this article.
December 5, 2017: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29201230/inhibition-of-penile-tunica-albuginea-myofibroblasts-activity-by-adipose-derived-stem-cells
#12
Hesong Jiang, Qingqiang Gao, Xiaoyan Che, Leilei Zhu, Zheng Zhang, Yun Chen, Yutian Dai
The activation of tunica albuginea myofibroblasts (MFs) serves an essential role in Peyronie's disease (PD). Increasing evidence has reported that adipose tissue-derived stem cells (ADSCs) have been demonstrated to attenuate the symptoms of PD in animal models. However, the mechanisms of the antifibrotic effects of ADSCs in PD remain to be fully elucidated. In the present study, the inhibitory effects and possible mechanism of ADSCs on the activation of MFs derived from rat penile tunica albuginea were investigated...
November 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29195031/surgical-correction-of-peyronie-s-disease-via-tunica-albuginea-plication-long-term-follow-up
#13
M Seveso, S Melegari, O De Francesco, A Macchi, J Romero Otero, G Taverna, G Bozzini
Peyronie's disease (PD) is an acquired connective tissue disorder of the tunica albuginea with fibrosis and inflammation that lead to palpable plaques formation, penile curvature, and pain during erection. Patients report negative effects on main domains such as physical appearance and self-image, sexual function, and performance. The aim of this study was to evaluate plication of the albuginea outcomes after a long-term follow-up period. Between 1998 and 2006, a total of 204 patients with PD underwent surgical correction with albuginea plication technique...
December 1, 2017: Andrology
https://www.readbyqxmd.com/read/29184789/effect-of-collagenase-clostridium-histolyticum-on-penile-vascular-and-morphological-parameters-in-patients-with-peyronie-s-disease
#14
Linley Diao, James Anaissie, Hoang Minh Tue Nguyen, Faysal A Yafi, Nora M Haney, Kenneth J DeLay, Taylor C Peak, Suresh C Sikka, Wayne J G Hellstrom
Background: To examine the changes in penile vascular parameters after the administration of collagenase Clostridium histolyticum (CCH) in patients with Peyronie's disease (PD). Methods: We retrospectively reviewed the records for all patients treated with CCH for PD between 04/2014 and 05/2017 who underwent penile duplex Doppler ultrasound (PDDU) after pharmacologically induced erection both before and after four cycles of CCH treatment. The primary outcomes measured were changes in peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) after CCH treatment...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29184788/racial-variations-in-response-to-intralesional-collagenase-clostridium-histolyticum-in-men-with-peyronie-s-disease
#15
Hoang Minh Tue Nguyen, Kenneth J DeLay, Linley Diao, Nora M Haney, James Anaissie, Faysal A Yafi, Suresh C Sikka, Wayne J G Hellstrom
Background: An examination of potential racial variations between Caucasian American (CA) and African American (AA) men in the efficacy and safety of collagenase clostridium histolyticum (CCH) in the treatment of Peyronie's disease (PD). Methods: We retrospectively reviewed the records for all patients treated with CCH for PD between 04/2014 and 05/2017. Patients were divided into two groups based on their self-reported race. The primary outcomes of interest were final change in curvature after CCH treatment regardless of number of CCH cycles received, and frequency of treatment-related adverse events (TRAEs)...
October 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/29174623/conservatively-managed-peyronie-s-disease-long-term-survey-results-from-patients-undergoing-nonsurgical-and-noninjection-therapies
#16
Matthew Ziegelmann, Raevti Bole, Ross Avant, David Yang, Brian Montgomery, Landon Trost
OBJECTIVE: To evaluate patient-reported temporal changes in penile curvature, pain, shortening, sexual function, and quality of life in men undergoing conservative treatment for PD. MATERIALS AND METHODS: Of 3840 patients who underwent evaluation at our institution between 1990 and 2012, 719 were randomly selected to receive a mail-in questionnaire with topics including penile curvature, pain, shortening, sexual function, and quality of life. Men endorsing prior intralesional or surgical therapy were excluded...
November 22, 2017: Urology
https://www.readbyqxmd.com/read/29151107/repeated-micro-trauma-of-the-penile-tunica-albuginea-a-new-animal-model-of-peyronie-s-disease
#17
Hesong Jiang, Qingqiang Gao, Xiaoyan Che, Leilei Zhu, Zheng Zhang, Yun Chen, Yutian Dai
OBJECTIVES: To compare effects of repairing injured tunica albuginea (PTA) of rat penis by single or repeated local injections of chlorhexidine ethanol (ChE) into the PTA and to establish a new animal model of Peyronie's disease (PD). MATERIALS AND METHODS: Forty-two rats were divided into 7 groups. Rats either served as the normal control group with 1-5 injections of 0.9% saline or they received a single injection, 2, 3, 4, or 5 injections of ChE (0.1% chlorhexidine gluconate plus 15% ethanol dissolved in saline); rats in the positive control group were injected with TGF-β1...
November 18, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29144916/re-bicentric-prospective-evaluation-of-corporoplasty-with-porcine-small-intestinal-submucosa-sis-in-patients-with-severe-peyronie-s-disease
#18
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29144915/re-safety-and-effectiveness-of-collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#19
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29144914/re-factors-associated-with-erectile-dysfunction-and-the-peyronie-s-disease-questionnaire-in-patients-with-peyronie-disease
#20
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
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