L L Cao, J G Yan, D N Feng, Y Dong, Z Q Xu, F C Wang, Y J Gao, S S Zhu, M Zhang
Objective: To analyze the clinical manifestations, pathology, and gene variant characteristics in children with progressive familial intrahepatic cholestasis type 3 (PFIC3). Methods: This retrospective study assessed the clinical manifestations, pathological features, gene variants, and prognosis data of 11 children with PFIC3 hospitalized in the Department of Hepatology, Fifth Medical Center, PLA General Hospital, from January 2015 to December 2022. Panel or whole exome sequencing was performed on the probands, followed by Sanger sequencing for verification within the family...
April 16, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics