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ruptured abdominal aortic aneurysm

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https://www.readbyqxmd.com/read/28212412/a-mathematical-model-of-aortic-aneurysm-formation
#1
Wenrui Hao, Shihua Gong, Shuonan Wu, Jinchao Xu, Michael R Go, Avner Friedman, Dai Zhu
Abdominal aortic aneurysm (AAA) is a localized enlargement of the abdominal aorta, such that the diameter exceeds 3 cm. The natural history of AAA is progressive growth leading to rupture, an event that carries up to 90% risk of mortality. Hence there is a need to predict the growth of the diameter of the aorta based on the diameter of a patient's aneurysm at initial screening and aided by non-invasive biomarkers. IL-6 is overexpressed in AAA and was suggested as a prognostic marker for the risk in AAA. The present paper develops a mathematical model which relates the growth of the abdominal aorta to the serum concentration of IL-6...
2017: PloS One
https://www.readbyqxmd.com/read/28195071/spatial-differences-of-matrix-metalloproteinase-2-and-matrix-metalloproteinase-9-within-abdominal-aortic-aneurysm-wall-and-intraluminal-thrombus
#2
A Siennicka, M Zuchowski, M Kaczmarczyk, M Cnotliwy, J S Clark, M Jastrzebska
Formation of an abdominal aortic aneurysm is a complex process involving aortic wall degradation. The matrix metalloproteinases (MMPs) mainly involved in this process are MMP-2 and MMP-9. Most aneurysms contain an intraluminal thrombus. It is suggested that the thrombus' thickness correlates with the risk of aneurysm rupture and may be a new prognostic factor. The purpose of the present study was to investigate enzyme protein levels in thick (A1) and thin (B1) segments of the thrombus and aneurysm wall sections A (adjacent to A1) and B (adjacent to B1)...
December 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28186202/inhibition-of-receptor-interacting-protein-kinase-1-with-necrostatin-1s-ameliorates-disease-progression-in-elastase-induced-mouse-abdominal-aortic-aneurysm-model
#3
Qiwei Wang, Ting Zhou, Zhenjie Liu, Jun Ren, Noel Phan, Kartik Gupta, Danielle M Stewart, Stephanie Morgan, Carmel Assa, K Craig Kent, Bo Liu
Abdominal aortic aneurysm (AAA) is a common aortic disease with a progressive nature. There is no approved pharmacological treatment to effectively slow aneurysm growth or prevent rupture. Necroptosis is a form of programmed necrosis that is regulated by receptor-interacting protein kinases (RIPs). We have recently demonstrated that the lack of RIP3 in mice prevented aneurysm formation. The goal of the current study is to test whether perturbing necroptosis affects progression of existing aneurysm using the RIP1 inhibitors Necrostatin-1 (Nec-1) and an optimized form of Nec-1, 7-Cl-O-Nec-1 (Nec-1s)...
February 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163172/endovascular-management-of-para-prosthetic-aortocaval-fistula-case-report-and-systematic-review-of-the-literature
#4
Claudio Bianchini Massoni, Giulia Rossi, Tiziano Tecchio, Paolo Perini, Antonio Freyrie
The aim of this article is to report a case of asymptomatic para-anastomotic aortocaval fistula (ACF) treated by endovascular aortic repair, and to review data of the literature on arteriovenous fistulae (AVF) secondary to abdominal aortic surgery. A 78-year-old male complained of worsening pain in the right lower limb since 2 months. He presented a history of right femoro-popliteal bypass for peripheral arterial occlusive disease and elective surgical treatment for a non-ruptured infrarenal aortic aneurysm (Dacron tube graft)...
February 2, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28155691/influence-of-endoleak-positions-on-the-pressure-shielding-ability-of-stent-graft-after-endovascular-aneurysm-repair-evar-of-abdominal-aortic-aneurysm-aaa
#5
Jie Li, Xiaopeng Tian, Zhenze Wang, Jiang Xiong, Yubo Fan, Xiaoyan Deng, Anqiang Sun, Xiao Liu
BACKGROUND: Abdominal aortic aneurysm (AAA) is a kind of dangerous aortic vascular disease, which is characterized by abdominal aorta partial enlargement. At present, endovascular aneurysm repair (EVAR) is one of the main treatments of abdominal aortic aneurysm. However for some patients after EVAR the aneurysm re-expanded and even ruptured, leading to poor postoperative effect. The stent-graft endoleak after EVAR was realized to influence the AAA in-sac pressure and contribute to the aneurysm re-enlargement...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155682/hemodynamics-study-of-a-multilayer-stent-for-the-treatment-of-aneurysms
#6
Yan Xiong, Xuhong Wang, Wentao Jiang, Xiaobao Tian, Qingyuan Wang, Yubo Fan, Yu Chen
BACKGROUND: The changes of hemodynamics caused by the implantation of multilayer stent (MS) have significant effects for aneurysm sac. METHODS: Comparisons of 3D numerical models with/without a MS in an abdominal aortic aneurysm with a 90° branch vessel were numerically studied from the viewpoint of hemodynamics. RESULTS: The results showed that: (1) The flow fields and Wall Shear Stress (WSS) are changed dramatically after MS implantation...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28155626/serum-calprotectin-as-a-novel-biomarker-in-abdominal-aortic-aneurysm-pathogenesis-and-progression-preliminary-data-from-experimental-model-in-rats
#7
Demetrios Moris, Stamatios Theocharis, Spyridon Davakis, Nikolaos Patelis, Georgios Agrogiannis, Ioannis S Vlachos, Eleftherios Spartalis, Antonios Athanasiou, Chris Bakoyiannis, Despina N Perrea, Sotirios Georgopoulos
BACKGROUND: Abdominal aortic aneurysm (AAA) formation is associated with by inflammation and matrix degradation. This study tested the hypothesis that calprotectin, a novel biomarker for inflammation, as well as established biomarkers such as C-reactive protein (CRP) and matrix metalloproteinase-9 (MMP-9) could also be indicative inflammatory biomarkers during AAA pathogenesis and progression. We also evaluated the correlation of serum soluble Receptor for Advanced Glycation End Products (sRAGE) with AAA diameter and serum calprotectin levels...
February 2, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28140767/ruptured-abdominal-aneurysm-disguised-as-an-incarcerated-inguinal-hernia
#8
J Colpaert, B Willaert, Y Van Molhem
An incarcerated inguinal hernia is a textbook example of a basic and straightforward diagnosis. In rare cases, an incarcerated hernia may be a symptom of more complex underlying pathology. In this case report a patient with a ruptured abdominal aortic aneurysm presented with an incarcerated left inguinal hernia. Only two other cases have been reported with a stable patient at initial presentation. The diagnosis was suspected when blood seeping next to the internal inguinal ring was detected, and an urgent ultrasound in the operating room confirmed the diagnosis...
January 31, 2017: Acta Chirurgica Belgica
https://www.readbyqxmd.com/read/28130287/very-late-rupture-of-a-post-traumatic-abdominal-aortic-pseudoaneurysm
#9
Haneen Abed, William Robert Ball, Timothy Stone, Andrew Houghton
Post-traumatic abdominal aortic pseudoaneurysms remain a rare yet severe complication of aortic injuries and may present many years later. Clinical presentations vary, from the traditional aneurysmal symptoms of abdominal and/or back pain with or without a pulsatile mass, to a fatal rupture. We present the case of a man aged 42 years, with a history of blunt abdominal trauma 14 years ago, presenting with symptoms of non-specific lower abdominal pain and a recent history of straining due to constipation. Clinical examination revealed umbilical bruising, in keeping with Cullen's sign, and extensive postsacral bruising...
January 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28126173/early-and-midterm-outcomes-after-transcatheter-embolization-of-type-i-endoleaks-in-25-patients
#10
Seyed Ameli-Renani, Vyzantios Pavlidis, Robert A Morgan
OBJECTIVE: This study reports the technical success and follow-up results of transcatheter embolization of type I endoleak (ELI) in 25 patients after endovascular aortic repair (EVAR). METHODS: Twenty-five patients with ELI (20 men, five women; mean age 80 years; range, 64-96 years) underwent embolization of abdominal ELI (23 proximal, 2 distal endoleaks) after EVAR. All patients were unsuitable for standard endovascular methods for treatment of ELI. The average aneurysm sac size before embolization was 8...
February 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28126017/ruptured-aortic-aneurysm-due-to-mycobacterium-bovis-bcg-with-a-delayed-bacteriological-diagnosis-due-to-false-negative-result-of-the-mpb-64-immunochromatographic-assay
#11
J Simar, L Belkhir, B Tombal, E André
BACKGROUND: Adjuvant therapy with bacillus Calmette-Guerin (BCG), a live attenuated strain of Mycobacterium bovis, has become the treatment of choice for low-risk superficial bladder carcinoma following transurethral resection of the bladder. Complications following vesical BCG instillations are uncommon but, in some cases, severe side-effects can occur such as sepsis or mycotic aneurysm. Besides usual laboratory techniques used for the diagnosis of Mycobacterium tuberculosis complex (MTBC) infections (smear microscopy and cultures), commercial immunochromatographic assays detecting MBP64, a 24 kDa M...
January 26, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28121282/how-to-identify-patients-at-risk-of-abdominal-compartment-syndrome-after-surgical-repair-of-ruptured-abdominal-aortic-aneurysms-in-the-operating-room-a-pilot-study
#12
Betty Leclerc, Lucie Salomon Du Mont, Guillaume Besch, Simon Rinckenbach
Objectives Abdominal compartment syndrome (ACS) is poorly identified in surgery for ruptured abdominal aortic aneurysm and an early management is crucial. The aim of this study was to validate how many risk factors were needed to predict ACS. Secondary objectives were to assess its prevalence and the 30-day mortality. Methods All patients operated for ruptured abdominal aortic aneurysm during 5 years were included. An independent committee performed a retrospective diagnosis of ACS. Eight criteria were selected from the literature, and corresponded to pre- and intraoperative period: anemia (hemoglobin lower than 10 g/dL), prolonged shock (systolic blood pressure <90 mmHg more than 18 min), preoperative cardiac arrest, obesity (body mass index > 30), massive fluid resuscitation (≥3500 mL per hour for at least 1 h) and transfusions (>10 units packed blood red cell since the beginning of the treatment), severe hypothermia (≤33℃), acidosis (pH < 7...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28116311/genetic-and-epigenetic-regulation-of-aortic-aneurysms
#13
REVIEW
Ha Won Kim, Brian K Stansfield
Aneurysms are characterized by structural deterioration of the vascular wall leading to progressive dilatation and, potentially, rupture of the aorta. While aortic aneurysms often remain clinically silent, the morbidity and mortality associated with aneurysm expansion and rupture are considerable. Over 13,000 deaths annually in the United States are attributable to aortic aneurysm rupture with less than 1 in 3 persons with aortic aneurysm rupture surviving to surgical intervention. Environmental and epidemiologic risk factors including smoking, male gender, hypertension, older age, dyslipidemia, atherosclerosis, and family history are highly associated with abdominal aortic aneurysms, while heritable genetic mutations are commonly associated with aneurysms of the thoracic aorta...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28115748/acute-aorta-overview-of-acute-ct-findings-and-endovascular-treatment-options
#14
Marie Cerna, Martin Kocher, Rohit Philip Thomas
Acute aortic pathologies include acute aortic syndrome (aortic dissection, intramural hematoma, penetrating aortic ulcer), impending rupture, aortic aneurysm rupture and aortic trauma. Acute aortic syndrome, aortic aneurysm rupture and aortic trauma are life-threatening conditions requiring prompt diagnosis and treatment. The basic imaging modality for "acute aorta" is CT angiography with typical findings for these aortic pathologies. Based on the CT, it is possible to classify aortic diseases and anatomical classifications are essential for the planning of treatment...
January 2, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28114868/endovascular-repair-of-contained-abdominal-aortic-aneurysm-rupture-using-a-bilateral-d-shaped-stent-system
#15
Nanouk van der Sluis, Ignace F J Tielliu, Clark J Zeebregts, Dainis Krievins, Paul M van Schaik
To report the first case of the treatment of a contained aortic aneurysm rupture using a bilateral D-shaped endovascular stent graft system.
January 1, 2017: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28110907/trends-in-patient-safety-of-intact-abdominal-aortic-aneurysm-repair-german-registry-data-on-36-594-procedures
#16
M Trenner, B Haller, M Storck, B Reutersberg, M A Kallmayer, H-H Eckstein
OBJECTIVE/BACKGROUND: The study aim was to determine whether patient safety for non-ruptured abdominal aortic aneurysm (nrAAA) repair has changed between 1999 and 2010 in a large German cohort. METHODS: The data source was the prospective quality assurance registry of the German Vascular Society from 1999 to 2010. Patient characteristics, surgical techniques (open aortic repair [OAR], endovascular aortic repair [EVAR]), procedural time and outcomes, including the length of hospital stay (LOS), were analysed using the Cochran-Armitage test for binary parameters and Spearman's correlation coefficient for quantitative parameters...
January 19, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28110838/molecular-imaging-of-abdominal-aortic-aneurysms
#17
REVIEW
Julia Brangsch, Carolin Reimann, Federico Collettini, Ralf Buchert, René M Botnar, Marcus R Makowski
Abdominal aortic aneurysms (AAAs) represent a vascular disease with severe complications. AAAs are currently the overall 10th leading cause of death in western countries and their incidence is rising. Although different diagnostic techniques are currently available in clinical practice, including ultrasound (US), magnetic resonance imaging (MRI), and computed tomography (CT), imaging-based prediction of life-threatening complications such as aneurysm-rupture remains challenging. Molecular imaging provides a novel diagnostic approach for in vivo visualization of biological processes and pathological alterations at a cellular and molecular level...
January 16, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28109395/hybrid-repair-of-ruptured-arch-aneurysm-without-sternotomy-through-an-unusual-extraanatomic-bypass
#18
Chung-Lin Tsai, Chih-Chun Yang, Takuya Fujikawa, Shih-Rong Hsieh
A 42-year-old man experienced a complex aortic arch aneurysm rupture. He had previously undergone an operation for type A dissection and had extremely poor cardiac performance as well as deep sternal infection after the first procedure. The conventional open repair was considered to be a high risk for this patient. We therefore performed an alternative hybrid aortic procedure. The supraarch vessels were perfused through an extraanatomic bypass from an unusual and remote route, namely, the abdominal aorta. Then, stent grafts were implanted in the previously replaced aortic prostheses to exclude the aortic aneurysm...
February 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28096831/predeployed-aortic-extension-cuff-kilt-in-evar-with-hostile-neck-anatomy-using-endurant-ii-system-preliminary-results
#19
Krzysztof Szaniewski, Magdalena Biernacka, Ryszard L Walas, Marian Zembala
INTRODUCTION: Various modifications of standard endovascular aortic aneurysm repair (EVAR) have been developed to solve the problem of difficult neck anatomy. AIM: The authors propose the implantation of a predeployed extension cuff (kilt) using on-shelf Endurant II elements. In a vast majority of cases, the proposed method provides a solution for the hostile neck problem using standard Endurant II elements available in all centers performing subrenal EVAR procedures...
December 2016: Kardiochirurgia i Torakochirurgia Polska, Polish Journal of Cardio-Thoracic Surgery
https://www.readbyqxmd.com/read/28095402/a-general-shear-dependent-model-for-thrombus-formation
#20
Alireza Yazdani, He Li, Jay D Humphrey, George Em Karniadakis
Modeling the transport, activation, and adhesion of platelets is crucial in predicting thrombus formation and growth following a thrombotic event in normal or pathological conditions. We propose a shear-dependent platelet adhesive model based on the Morse potential that is calibrated by existing in vivo and in vitro experimental data and can be used over a wide range of flow shear rates ([Formula: see text]). We introduce an Eulerian-Lagrangian model where hemodynamics is solved on a fixed Eulerian grid, while platelets are tracked using a Lagrangian framework...
January 2017: PLoS Computational Biology
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