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ruptured abdominal aortic aneurysm

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https://www.readbyqxmd.com/read/28342508/gender-smoking-body-size-and-aneurysm-geometry-influence-the-biomechanical-rupture-risk-of-abdominal-aortic-aneurysms-as-estimated-by-finite-element-analysis
#1
Moritz Lindquist Liljeqvist, Rebecka Hultgren, Antti Siika, T Christian Gasser, Joy Roy
OBJECTIVE: Finite element analysis (FEA) has been suggested to be superior to maximal diameter measurements in predicting rupture of abdominal aortic aneurysms (AAAs). Our objective was to investigate to what extent previously described rupture risk factors were associated with FEA-estimated rupture risk. METHODS: One hundred forty-six patients with an asymptomatic AAA of a 40- to 60-mm diameter were retrospectively identified and consecutively included. The patients' computed tomography angiograms were analyzed by FEA without (neutral) and with (specific) input of patient-specific mean arterial pressure (MAP), gender, family history, and age...
April 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28338434/coexistence-of-obstructive-sleep-apnea-worsens-the-overall-outcome-of-intracranial-aneurysm-a-pioneer-study
#2
Shyamal C Bir, Anil Nanda, Hugo Cuellar, Hai Sun, Bharat Guthikonda, Cesar Liendo, Alireza Minagar, Oleg Y Chernyshev
OBJECTIVE Obstructive sleep apnea (OSA) is associated with the progression of abdominal and thoracic aortic aneurysms. However, the role of OSA in the overall outcome of intracranial aneurysms (IAs) has not yet been established. Authors of this report investigated the role of OSA in the overall outcome of IAs. METHODS Radiological and clinical data on patients (from 2010 through 2015) with confirmed IA were retrospectively reviewed. Significant differences between the OSA and non-OSA groups were determined using a chi-square test...
March 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28335156/should-the-prediction-of-mortality-at-30-days-in-patients-treated-for-a-ruptured-abdominal-aortic-aneurysm-take-into-account-the-specialization-of-the-surgical-unit
#3
Ambroise Duprey, Thomas Varin, Charlène Hannequin, Fabien Heller, Caroline Haase-Ruby, Jean-Noël Albertini, Jean-Pierre Favre
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28321413/fluid-structure-interaction-in-abdominal-aortic-aneurysm-effect-of-modeling-techniques
#4
Shengmao Lin, Xinwei Han, Yonghua Bi, Siyeong Ju, Linxia Gu
In this work, the impact of modeling techniques on predicting the mechanical behaviors of abdominal aortic aneurysm (AAA) is systematically investigated. The fluid-structure interaction (FSI) model for simultaneously capturing the transient interaction between blood flow dynamics and wall mechanics was compared with its simplified techniques, that is, computational fluid dynamics (CFD) or computational solid stress (CSS) model. Results demonstrated that CFD exhibited relatively smaller vortexes and tends to overestimate the fluid wall shear stress, compared to FSI...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28320001/review-1-time-ultrasonography-screening-reduces-abdominal-aortic-aneurysm-related-mortality-and-rupture
#5
Calvin Hirsch
No abstract text is available yet for this article.
March 21, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28318603/rupture-risk-in-abdominal-aortic-aneurysms-a-realistic-assessment-of-the-explicit-gpu-approach
#6
V Strbac, D M Pierce, B Rodriguez-Vila, J Vander Sloten, N Famaey
Accurate estimation of peak wall stress (PWS) is the crux of biomechanically motivated rupture risk assessment for abdominal aortic aneurysms aimed to improve clinical outcomes. Such assessments often use the finite element (FE) method to obtain PWS, albeit at a high computational cost, motivating simplifications in material or element formulations. These simplifications, while useful, come at a cost of reliability and accuracy. We achieve research-standard accuracy and maintain clinically applicable speeds by using novel computational technologies...
February 27, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28302917/hif1%C3%AE-in-aortic-aneurysms-and-beyond
#7
Tomoki Hashimoto, Victor Rizzo
Abdominal aortic aneurysm (AAA) is a permanent expansion of the vessel wall with a high prevalence in those 65 years of age and older. Aneurysms are prone to dissection and rupture that carry a mortality rate of over 85%. Currently, surgical repair is the only option to treat this disease. The need to intervene prior to these events has set off a flurry of basic studies in an effort to understand the cellular and molecular mechanisms that govern AAA formation, progression and rupture. In the present study, the role of myeloid cells in contributing to AAA development has been confirmed...
April 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28296545/the-effects-of-nicotine-administration-on-the-pathophysiology-of-rat-aortic-wall
#8
H Kugo, N Zaima, H Tanaka, T Urano, N Unno, T Moriyama
Abdominal aortic aneurysm (AAA) is the progressive dilation of the abdominal aorta. Nicotine is reported to be associated with the development and rupture of AAA, but the pathological effects of nicotine on normal rat aorta have not been determined. We investigated pathological changes in the aortic wall of rats caused by the administration of nicotine. Nicotine administration weakened the vascular wall, increased gelatinolytic activity and promoted the destruction of elastin and collagen in the rat abdominal aorta...
2017: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/28288888/a-novel-modification-of-the-murine-elastase-infusion-model-of-abdominal-aortic-aneurysm-formation
#9
Guohua Hu, Zhihui Dong, Weiguo Fu
OBJECT: To create a novel procedure that will decrease the mortality of experimental animals in the intra-arterial infusion of elastase abdominal aortic aneurysm model. METHODS: Novel models were created by means of direct puncture the infrarenal abdominal aortic aorta, intraluminal elastase in the 1cm segment of abdominal aorta. Femoral artery cannula approach and infusing with elastase was considered as the traditional group, and that infusing with saline solution as the control group...
March 10, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28288886/the-atmospheric-pressure-and-temperature-seem-to-have-no-effect-on-the-incidance-of-rupture-of-abdmonial-aortic-aneurysm-in-a-mid-european-region
#10
Payman Majd, Wael Ahmad, Thomas Luebke, Jan Sigge Brunkwall
BACKGROUND/OBJECTIVE: This study aims to examine the relationship between weather changes (atmospheric pressure and temprature) and incidence of rupture of abdominal aortic aneurysm. METHODS: All patients with ruptured infrarenal abdominal aortic aneurysm (AAA) and who were referred to our institution between August 1998 and August 2015 were prospectively entered into a database out of which a retrospective review of a ruptured AAA was performed. The needed information about the daily atmospheric pressure and air temperature could be extracted from the meteorological unit in Cologne...
March 10, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28288885/patients-with-ruptured-abdominal-aortic-aneurysm-have-become-higher-risk
#11
Anoosha Aslam, Charles M Fisher, Cathy Thoo, Michael L Neale, Shannon D Thomas
BACKGROUND: Independent risk factors such as age, loss of consciousness, elevated serum creatinine, low haemoglobin and ECG evidence of ischemia have previously been shown to predict mortality after ruptured abdominal aortic aneurysm (rAAA). With an ageing Australian population, we sought to determine if patients presenting with rAAA now had more predictive risk factors for mortality, and whether these factors remain predictive of mortality. METHODS: The records of all patients presenting with rAAA between January 1985 to December 1993 (past era, group 1) and January 2007 to December 2011 (modern era, group 2) were retrieved...
March 10, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28288701/abdominal-aortic-aneurysm-and-omega-3-polyunsaturated-fatty-acids-mechanisms-animal-models-and-potential-treatment
#12
REVIEW
Lara T Meital, Shaun L Sandow, Philip C Calder, Fraser D Russell
Abdominal aortic aneurysm (AAA) is an inflammatory disease associated with macrophage accumulation in the adventitia, oxidative stress, medial elastin degradation and aortic dilation. Progression of AAA is linked to increased risk of rupture, which carries a high mortality rate. Drug therapies trialled to date lack efficacy and although aneurysm repair is available for patients with large aneurysm, peri-surgical morbidity and mortality have been widely reported. Recent studies using rodent models of AAA suggest that long chain omega-3 polyunsaturated fatty acids (LC n-3 PUFAs) and their metabolites can moderate inflammation and oxidative stress perpetuated by infiltrating macrophages and intervene in the destruction of medial elastin...
March 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28282590/correlation-between-transversal-and-orthogonal-maximal-diameters-of-abdominal-aortic-aneurysms-and-alternative-rupture-risk-predictors
#13
Kamil Novak, Stanislav Polzer, Tomas Krivka, Robert Vlachovsky, Robert Staffa, Lubos Kubicek, Lukas Lambert, Jiri Bursa
PURPOSE: There is no standard for measuring maximal diameter (Dmax) of abdominal aortic aneurysm (AAA) from computer tomography (CT) images although differences between Dmax evaluated from transversal (axialDmax) or orthogonal (orthoDmax) planes can be large especially for angulated AAAs. Therefore we investigated their correlations with alternative rupture risk indicators as peak wall stress (PWS) and peak wall rupture risk (PWRR) to decide which Dmax is more relevant in AAA rupture risk assessment...
March 6, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28274752/a-novel-chronic-advanced-stage-abdominal-aortic-aneurysm-murine-model
#14
Guanyi Lu, Gang Su, John P Davis, Basil Schaheen, Emily Downs, R Jack Roy, Gorav Ailawadi, Gilbert R Upchurch
OBJECTIVE: The purpose of this study was to establish a reliable, chronic model of abdominal aortic aneurysm (AAA). METHODS: Wild-type 8-week-old C56BL/6 male mice (n = 120) were equally divided into three groups: (1) BAPN group: 0.2% 3-aminopropionitrile fumarate salt (BAPN) drinking water was provided to mice 2 days before surgery until the end of study. Sham aneurysm induction surgery was performed using 5 μL of heat deactivated elastase. (2) Elastase group: mice were given regular drinking water without BAPN...
March 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28274712/significant-changes-in-combined-consistent-biomarkers-and-computed-tomography-angiography-revealed-during-an-interval-of-6months-before-abdominal-aortic-aneurysm-rupture
#15
Pawel Szumilowicz, Ireneusz Wiernicki, Arkadiusz Kazimierczak, Elzbieta Golubinska-Szemitko, Joanna Zurkowska, Piotr Kasprzak
The most commonly used predictor of rupture of abdominal aortic aneurysm (AAA) is the diameter, but this does not correlate well with the risk of rupture. Therefore, in order to make further improvements in clinical decisions regarding AAA patients, the development of additional predictive tools other than aneurysm size alone is needed. We herein report a case of a 72-year-old man with AAA that underwent rupture transformation during six months. We review the morphological features changes detected by computed tomography and also observe several alters circulating biomarkers at the same time...
February 28, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28268109/the-incidence-and-fate-of-endoleaks-vary-between-ruptured-and-elective-endovascular-abdominal-aortic-aneurysm-repair
#16
Adam A Quinn, Manish Mehta, Mehdi J Teymouri, Megan E Keenan, Philip S K Paty, Yi Zhou, Benjamin B Chang, Paul Feustel
BACKGROUND: The number of ruptured abdominal aortic aneurysm (r-AAA) patients who are treated by endovascular means is increasing as ruptured endovascular aneurysm repair (r-EVAR) enters the mainstream. However, even today, data on the incidence and behavior of endoleaks after r-EVAR are scarce. This study analyzed whether endoleaks behave differently after EVAR for rupture vs elective AAA repair. METHODS: From 2002 to 2013, there were 2052 patients who underwent EVAR for treatment of rupture (n = 166 [8...
March 4, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28259577/outcomes-of-fenestrated-and-branched-endovascular-repair-of-complex-abdominal-and-thoracoabdominal-aortic-aneurysms
#17
Andres Schanzer, Jessica P Simons, Julie Flahive, Jonathan Durgin, Francesco A Aiello, Danielle Doucet, Robert Steppacher, Louis M Messina
BACKGROUND: More than 80% of infrarenal aortic aneurysms are treated by endovascular repair. However, adoption of fenestrated and branched endovascular repair for complex aortic aneurysms has been limited, despite high morbidity and mortality associated with open repair. There are few published reports of consecutive outcomes, inclusive of all fenestrated and branched endovascular repairs, starting from the inception of a complex aortic aneurysm program. Therefore, we examined a single center's consecutive experience of fenestrated and branched endovascular repair of complex aortic aneurysms...
March 1, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28259576/female-sex-independently-predicts-mortality-after-thoracic-endovascular-aortic-repair-for-intact-descending-thoracic-aortic-aneurysms
#18
Sarah E Deery, Katie E Shean, Grace J Wang, James H Black, Gilbert R Upchurch, Kristina A Giles, Virendra I Patel, Marc L Schermerhorn
OBJECTIVE: Whereas sex differences in the pathogenesis, presentation, and outcomes of repair for abdominal aortic aneurysms are well studied, less is known about sex differences after thoracic endovascular aortic repair (TEVAR). The goal of this study was to evaluate the association between sex and morbidity and mortality after TEVAR. METHODS: A retrospective review of all TEVARs in the Society for Vascular Surgery Vascular Quality Initiative (VQI) registry from 2011 to 2015 was conducted, excluding those with dissection, trauma, and rupture...
March 1, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28256396/adjusted-hospital-outcomes-of-abdominal-aortic-aneurysm-surgery-reported-in-the-dutch-surgical-aneurysm-audit
#19
N Lijftogt, A C Vahl, E D Wilschut, B H P Elsman, S Amodio, E W van Zwet, V J Leijdekkers, M W J M Wouters, J F Hamming
OBJECTIVE/BACKGROUND: The Dutch Surgical Aneurysm Audit (DSAA) is mandatory for all patients with primary abdominal aortic aneurysms (AAAs) in the Netherlands. The aims are to present the observed outcomes of AAA surgery against the predicted outcomes by means of V-POSSUM (Vascular-Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity). Adjusted mortality was calculated by the original and re-estimated V(physiology)-POSSUM for hospital comparisons. METHODS: All patients operated on from January 2013 to December 2014 were included for analysis...
February 28, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28256324/time-trends-in-hospital-admissions-and-mortality-due-to-abdominal-aortic-aneurysms-in-france-2002-2013
#20
M Robert, Y Juillière, A Gabet, S Kownator, V Olié
BACKGROUND: Abdominal aortic aneurysms (AAA) are serious disease with a high fatality rate but recent epidemiologic data showed a decrease of AAA mortality. Our objective was to estimate, in France, the hospitalization, inhospital mortality and mortality rates due to AAA and to analyze their trends over time. METHODS: Hospitalization data were extracted from the hospital discharge summaries in the national database between 2002 and 2013. The analysis covered all patients hospitalized for AAA as a principal diagnosis...
May 1, 2017: International Journal of Cardiology
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