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ruptured abdominal aortic aneurysm

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https://www.readbyqxmd.com/read/28431866/circulating-micrornas-signature-correlates-with-positive-18-f-fluorodeoxyglucose-positron-emission-tomography-in-patients-with-abdominal-aortic-aneurysm
#1
Audrey Courtois, Betty Nusgens, Nancy Garbacki, Roland Hustinx, Pierre Gomez, Jean-Olivier Defraigne, Alain C Colige, Natzi Sakalihasan
BACKGROUND: Prediction of abdominal aortic aneurysm (AAA) rupture is a challenging issue. Small noncoding microRNAs (miRNAs) are potent regulators of gene expression and are considered as valuable circulating biomarkers. Recently, [(18)F]fluorodeoxyglucose (FDG) uptake detected by positron emission tomography (PET) in AAA was correlated with cellular and molecular alterations involved in wall instability and its potential rupture. Our study aimed at identifying circulating miRNAs correlated with a positive PET that could help discriminate patients at high risk of rupture...
April 18, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28431107/double-fixation-for-abdominal-aortic-aneurysm-repair-using-afx-body-and-endurant-proximal-aortic-cuff-mid-term-results
#2
Miltiadis I Matsagkas, George Kouvelos, Konstantinos Spanos, Athanasios Athanasoulas, Athanasios Giannoukas
Our goal was to evaluate the use of an AFX main body combined with an Endurant proximal aortic cuff to treat selected patients with an abdominal aortic aneurysm (AAA) associated with anatomical challenges, such as a small distal aortic diameter and a hostile aortic neck. A retrospective analysis of prospectively collected data from 2 vascular institutions identified 14 elective patients with an AAA (all men, 73.5 ± 5.1 years) treated with the AFX main body combined with an Endurant proximal aortic cuff...
April 17, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28420827/relaxin-and-matrix-metalloproteinase-9-in-angiotensin-ii-induced-abdominal-aortic-aneurysms
#3
Deborah A Howatt, Maya Dajee, Xiaojie Xie, Jessica Moorleghen, Debra L Rateri, Anju Balakrishnan, Valdeci Da Cunha, Douglas G Johns, David E Gutstein, Alan Daugherty, Hong Lu
BACKGROUND: This study determined whether relaxin or matrix metalloproteinase (MMP)-9 influences angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA).Methods and Results:Male C57BL/6 or apolipoprotein E(-/-)mice were infused with AngII with or without relaxin. Relaxin did not influence AngII-induced AAA in either mouse strain. Infusion of AngII reduced, but relaxin increased, MMP-9 mRNA in macrophages. We then determined the effects of MMP-9 deficiency on AAA in apolipoprotein E(-/-)mice...
April 18, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28416930/what-are-the-prevalence-of-abdominal-aortic-aneurysm-in-patients-with-chronic-obstructive-pulmonary-diseases-and-the-characteristics-of-these-patients
#4
Ulku Aka Akturk, Nagihan Durmus Kocak, Suleyman Akturk, Mert Dumantepe, Aysun Sengul, Mehmet Arif Akcay, Makbule Ozlem Akbay, Feyyaz Kabadayi, Dilek Ernam
OBJECTIVE: To determine the prevalence of abdominal aortic aneurysm (AAA) in patients with chronic obstructive pulmonary disease (COPD) and to assess the characteristics of these patients. MATERIALS AND METHODS: Stable COPD patients (age, >40 years) were included in the study between January 2014 and June 2014. Patients with acute exacerbations and a previous lung resection were excluded. Data regarding demographic characteristics were recorded. The modified Medical Research Council (mMRC) dyspnea scale was used to assess the severity of breathlessness...
February 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28416191/assessment-of-international-outcomes-of-intact-abdominal-aortic-aneurysm-repair-over-9-years
#5
J Budtz-Lilly, M Venermo, S Debus, C-A Behrendt, M Altreuther, B Beiles, Z Szeberin, N Eldrup, G Danielsson, I Thomson, P Wigger, M Björck, I Loftus, K Mani
BACKGROUND: Case mix and outcomes of complex surgical procedures vary over time and between regions. This study analyses peri-operative mortality after intact abdominal aortic aneurysm (AAA) repair in 11 countries over 9 years. METHODS: Data on primary AAA repair from vascular surgery registries in 11 countries for the years 2005-2009 and 2010-2013 were analysed. Multivariate adjusted logistic regression analyses were carried out to adjust for variations in case mix...
April 13, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28412911/pharmacological-therapy-of-abdominal-aortic-aneurysm-an-update
#6
Yi-Dong Wang, Zhen-Jie Liu, Jun Ren, Mei-Xiang Xiang
Abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic dilation, is associated with high mortality. AAA is characterized by inflammation, smooth muscle cell (SMC) depletion and extracellular matrix (ECM) degradation. Surgical intervention and endovascular therapy are recommended to prevent rupture of large AAAs. Unfortunately, there is no reliable pharmacological agent available to limit AAA expansion. In the past decades, extensive investigations and a body of ongoing clinical trials aimed at defining potent treatments to inhibit and even regress AAA growth...
April 13, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28410259/central-venous-catheter-placement-in-the-left-internal-jugular-vein-complicated-by-perforation-of-the-left-brachiocephalic-vein-and-massive-hemothorax-a-case-report
#7
Lindsay R Wetzel, Priyesh R Patel, Nicholas L Pesa
An elderly male presented for emergent repair of a ruptured abdominal aortic aneurysm. For anticipated volume resuscitation, vasopressor administration, and hemodynamic monitoring, a large-bore central venous catheter was placed in the left internal jugular vein under ultrasound guidance before surgical incision. Initially, there were no readily apparent signs of venous perforation. However, a massive left hemothorax developed because of perforation of the brachiocephalic vein and violation of the pleural space...
April 13, 2017: A & A Case Reports
https://www.readbyqxmd.com/read/28406184/monocytes-and-macrophages-in-abdominal-aortic-aneurysm
#8
REVIEW
Juliette Raffort, Fabien Lareyre, Marc Clément, Réda Hassen-Khodja, Giulia Chinetti, Ziad Mallat
Abdominal aortic aneurysm (AAA) is a life-threatening disease associated with high morbidity, and high mortality in the event of aortic rupture. Major advances in open surgical and endovascular repair of AAA have been achieved during the past 2 decades. However, drug-based therapies are still lacking, highlighting a real need for better understanding of the molecular and cellular mechanisms involved in AAA formation and progression. The main pathological features of AAA include extracellular matrix remodelling associated with degeneration and loss of vascular smooth muscle cells and accumulation and activation of inflammatory cells...
April 13, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/28395784/acute-mesenteric-ischemia-part-i-incidence-etiologies-and-how-to-improve-early-diagnosis
#9
REVIEW
Jussi M Kärkkäinen, Stefan Acosta
Acute mesenteric ischemia (AMI) is generally thought to be a rare disease, but in fact, it is more common cause of acute abdomen than appendicitis or ruptured abdominal aortic aneurysm in patients over 75 years of age. In occlusive AMI, surgical treatment without revascularization is associated with as high as 80% overall mortality. It has been shown that early diagnosis with contrast-enhanced computed tomography and revascularization can reduce the overall mortality in AMI by up to 50%. However, only a minority of patients with AMI are being treated actively with revascularization in the United States, and the situation is very likely similar in Europe as well...
February 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28394003/prevalence-of-abdominal-aortic-aneurysms-in-rural-urban-population-in-central-poland
#10
Tadeusz L Dereziński, Bartosz Fórmankiewicz, Arkadiusz Migdalski, Paweł Brazis, Grzegorz Jakubowski, Łukasz Woda, Arkadiusz Jawień
BACKGROUND: Abdominal aortic aneurysm (AAA) is a widening of the aorta below the renal arteries with a diameter equal or greater than 3 cm. The prevalence of AAA is estimated at 4-8% in men aged 65 years or older and 1-2% among women over 65 years. Participation in screening programs has decreased the number of aortic ruptures. METHODS: All men aged 60 years and older, and women aged 65 and older living in the rural/urban commune in Central Poland were invited to the participation in the study...
April 10, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28392057/trend-break-in-abdominal-aortic-aneurysm-repair-with-decreasing-surgical-workload
#11
F Lilja, K Mani, A Wanhainen
BACKGROUND: The epidemiology and management of abdominal aortic aneurysms (AAAs) has changed drastically in the past decades, with implementation of nationwide screening programs, introduction of endovascular repair (EVAR), and reduced prevalence of the disease. This report aims to assess recent trends in AAA repair epidemiology in Sweden in this context. METHODS: Primary AAA repairs registered in the nationwide Swedish Vascular Registry (Swedvasc) 1994-2014 were analyzed regarding patient characteristics, repair incidence, technique, and outcome...
April 5, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28386544/use-of-nanoparticles-as-contrast-agents-for-the-functional-and-molecular-imaging-of-abdominal-aortic-aneurysm
#12
REVIEW
Theophilus I Emeto, Faith O Alele, Amy M Smith, Felicity M Smith, Tammy Dougan, Jonathan Golledge
Abdominal aortic aneurysm (AAA) is a degenerative disease of the aorta common in adults older than 65 years of age. AAA is usually imaged using ultrasound or computed tomography. Molecular imaging technologies employing nanoparticles (NPs) have been proposed as novel ways to quantify pathological processes, such as inflammation, within AAAs as a means to identify the risk of rapid progression or rupture. This article reviews the current evidence supporting the role of NP-based imaging in the management of AAA...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28381776/pathological-analysis-of-the-ruptured-vascular-wall-of-hypoperfusion-induced-abdominal-aortic-aneurysm-animal-model
#13
Hirona Kugo, Nobuhiro Zaima, Hiroki Tanaka, Keisuke Hashimoto, Chie Miyamoto, Ayaka Sawaragi, Tetsumei Urano, Naoki Unno, Tatsuya Moriyama
Abdominal aortic aneurysm (AAA) is a vascular disease that results in the gradual dilation of the abdominal aorta and has a high rupture-related mortality rate. However, the mechanism of AAA rupture remains unknown. In our previous study, we established a novel AAA animal model (hypoperfusion-induced AAA rat model) with spontaneous AAA rupture. Using the hypoperfusion-induced AAA rat model, we demonstrated that the abnormal appearance of adipocytes in the vascular wall is associated with AAA rupture. However, pathological analysis of the rupture area has not been performed because it is particularly difficult to identify the rupture point...
April 4, 2017: Journal of Oleo Science
https://www.readbyqxmd.com/read/28378165/correlation-of-wall-microstructure-and-heterogeneous-distributions-of-strain-in-evolving-murine-abdominal-aortic-aneurysms
#14
John S Wilson, Matthew R Bersi, Guangxin Li, Jay D Humphrey
A primary deficiency in predicting the progression and rupture-risk of abdominal aortic aneurysms (AAAs) is an inability to assign patient-specific, heterogeneous biomechanical properties to the remodelling aortic wall. Toward this end, we investigated possible correlations between three quantities having the potential for non-invasive measurement (diameter, wall thickness, and strain) and local wall microstructure within evolving experimental AAAs. AAAs were initiated in male C57BL/6J mice via in situ adventitial application of elastase and allowed to progress for 1-4 weeks...
April 4, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/28369137/inhibition-of-endoplasmic-reticulum-stress-signaling-pathway-a-new-mechanism-of-statins-to-suppress-the-development-of-abdominal-aortic-aneurysm
#15
Yuanyuan Li, Gangsheng Lu, Dating Sun, Houjuan Zuo, Dao Wen Wang, Jiangtao Yan
BACKGROUND: Abdominal aortic aneurysm (AAA) is a potentially lethal disease with extremely poor survival rates once the aneurysm ruptures. Statins may exert beneficial effects on the progression of AAA. However, the underlying mechanism is still not known. The purpose of the present study is to investigate whether statin could inhibit AAA formation by inhibiting the endoplasmic reticulum (ER) stress signal pathway. METHODS: A clinically relevant AAA model was induced in Apolipoprotein E-deficient (ApoE-/-) mice, which were infused with angiotensin II (Ang II) for 28 days...
2017: PloS One
https://www.readbyqxmd.com/read/28366303/comparison-of-midterm-results-for-the-talent-and-endurant-stent-graft
#16
Yannick W 't Mannetje, Philippe W M Cuypers, Ben R Saleem, Aron S Bode, Joep A W Teijink, Marc R H M van Sambeek
OBJECTIVE: Stent graft evolution is often addressed as a cause for improved outcomes of endovascular aneurysm repair for patients with an abdominal aortic aneurysm. In this study, we directly compared the midterm result of Endurant stent graft with its predecessor, the Talent stent graft (both Medtronic, Santa Rosa, Calif). METHODS: Patient treated from January 2005 to December 2010 in a single tertiary center in The Netherlands with a Talent or Endurant stent graft were eligible for inclusion...
March 30, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28365786/clues-to-vascular-disorders-at-non-contrast-ct-of-the-chest-abdomen-and-pelvis
#17
REVIEW
Yonah B Esterson, Jennifer L Berkowitz, Barak Friedman, John J Hines, Priya K Shah, Gregory M Grimaldi
Non-contrast chest CT scans are commonly performed while CT scans of the abdomen and pelvis are performed in a select subset of patients; those with limited renal function, an allergy to iodinated contrast, in the setting of suspected renal calculus, retroperitoneal hematoma, common duct calculus, abdominal aortic aneurysm with or without rupture, and in patients undergoing a PET-CT scan. In the absence of intravenous contrast, vascular structures may prove challenging to evaluate, yet their assessment is an important component of every non-contrast CT examination...
April 1, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28359718/impact-of-surgeon-and-hospital-experience-on-outcomes-of-abdominal-aortic-aneurysm-repair-in-new-york-state
#18
Andrew J Meltzer, Peter H Connolly, Darren B Schneider, Art Sedrakyan
OBJECTIVE: This study aimed to assess the impact of the surgeon's and hospital's experience on the outcomes of open surgical repair (OSR) and endovascular aneurysm repair (EVAR) of intact and ruptured abdominal aortic aneurysms (AAAs) in New York State. METHODS: New York Statewide Planning and Research Cooperative System data were used to identify patients undergoing AAA repair from 2000 to 2011. Characteristics of the provider and hospital were determined by linkage to the New York Office of Professions and National Provider Identification databases...
March 27, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28356210/outcome-after-ruptured-aaa-repair-in-octo-and-nonagenarians-in-sweden-1994-2014
#19
B Sonesson, K Björses, N Dias, R Rylance, K Mani, A Wanhainen, T Resch
OBJECTIVE: To report the outcome after ruptured abdominal aortic aneurysm (rAAA) repair in octo- and nonagenarians from the Swedish Vascular Registry 1994-2014. MATERIAL AND METHODS: 2335 intact AAA (iAAA) and 1538 rAAA were identified in patients aged 80 years and older. Crude, long-term, and relative survival data were analysed using the Kaplan-Meier method. Crude survival was calculated including all deaths. Long-term survival was analysed excluding AAA repair related mortality, defined as death within 90 days of surgery...
March 26, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28351494/perfusion-computed-tomography-imaging-of-abdominal-aortic-aneurysms-may-be-of-value-for-patient-specific-rupture-risk-estimation
#20
Nikolaos Kontopodis, Nikolaos Galanakis, Dimitrios Tsetis, Christos V Ioannou
Abdominal aortic aneurysm (AAA) continues to pose a significant cause of unexpected mortality in the developed countries with its incidence constantly rising. The indication of elective surgical repair is currently based on the maximum diameter and growth rate criteria which represent an oversimplification of the Law of Laplace stating that the stress exerted in a cylinder or sphere is proportional to its radius. These criteria fail to capture the complex pathophysiology of the aneurismal disease thus often leading to therapeutic inaccuracies (treating large AAAs with a very low actual rupture risk while observing smaller ones with a much greater risk)...
April 2017: Medical Hypotheses
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