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Hyo Ju Na, Song Soo Kim, Shinhye Cheon, Jin Hwan Kim, Hyeyoung Kwon
Mucormycosis encompasses a range of fungal infections that can impact various organs. Although pulmonary mucormycosis is relatively rare, it poses a significant threat, particularly to individuals with compromised immune systems. Pulmonary mucormycosis presents with various radiological manifestations. Notably, the involvement of the angioinvasive pulmonary artery in pulmonary mucormycosis cases has seldom been documented. In this report, we showcase the radiological characteristics of angioinvasive mucormycosis, which can mimic pulmonary thromboembolism or a pulmonary artery tumor, in a patient diagnosed with myelodysplastic syndrome...
March 2024: J Korean Soc Radiol
#22
Julie Benzakine, Carla Rial, Nassim Mohamedi, Emmanuel Messas, Laetitia Mauge, Marc Sapoval, Nicolas Gendron, Lina Khider
BACKGROUND: Inherited antithrombin (AT) deficiency (ATD) is a severe thrombophilia causing venous thromboembolism, which can be complicated by postthrombotic syndrome (PTS). Venous recanalization, used to treat PTS, often requires a temporary withdrawal of anticoagulant therapy. In ATD patients, there is a risk of insufficient perioperative anticoagulation due to altered heparin response. KEY CLINICAL QUESTION: There is no consensus on how to manage perioperative anticoagulation in ATD patients...
March 2024: Research and Practice in Thrombosis and Haemostasis
#23
JOURNAL ARTICLE
Lorenzo Gervaso, Alice Laffi, Aurora Gaeta, Sara Gandini, Laura Boldrini, Monica Isabel Meneses-Medina, Manila Rubino, Lavinia Benini, Michele Borghesani, Laura Algeri, Giuseppe Curigliano, Francesca Spada, Chiara Alessandra Cella, Nicola Fazio
No abstract text is available yet for this article.
March 2024: Research and Practice in Thrombosis and Haemostasis
#24
JOURNAL ARTICLE
Yamin Zhang, Yanghao Zheng, Peiyan Ni, Sugai Liang, Xiaojing Li, Hua Yu, Wei Wei, Xueyu Qi, Xueli Yu, Rui Xue, Liansheng Zhao, Wei Deng, Qiang Wang, Wanjun Guo, Tao Li
BACKGROUND: Elevated platelet count (PLTc) is associated with first-episode schizophrenia and adverse outcomes in individuals with precursory psychosis. However, the impact of antipsychotic medications on PLTc and its association with symptom improvement remain unclear. AIMS: We aimed to investigate changes in PLTc levels following antipsychotic treatment and assess whether PLTc can predict antipsychotic responses and metabolic changes after accounting for other related variables...
2024: General Psychiatry
#25
REVIEW
Jakub Maksym, Marcin Grabowski, Tomasz Mazurek
Atrial fibrillation (AF) is the most commonly observed arrhythmia in the world and its prevalence increases with age. The main and most severe complication of AF is ischemic stroke. Oral anticoagulation (OAC) therapy is the standard of care for stroke prevention in the high risk population. Initiation of this treatment is associated with a substantial risk of bleeding complications. Moreover, there is a group of patients who cannot tolerate OAC. In patients with AF the left atrial appendage (LAA) is the main source of thrombus formation...
March 2024: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
#26
JOURNAL ARTICLE
Andrzej Łabyk, Marcin Krakowian, Łukasz Mysiorski, Barbara Lichodziejewska, Olga Dzikowska-Diduch, Aisha Ou-Pokrzewińska, Dariusz Zieliński, Marek Gołębiowski, Piotr Pruszczyk, Marek Roik
INTRODUCTION: Chronic thromboembolic pulmonary hypertension (CTEPH), characterized by thromboembolic changes affecting the pulmonary bed, leads to ventricular function deterioration and premature death. The introduction of balloon pulmonary angioplasty (BPA) has significantly improved the prognosis of CTEPH patients. AIM: The authors of this article decided to summarize the experience of the BPA program, conducted between 2014 and 2022, at the reference center. MATERIAL AND METHODS: Among 111 CTEPH patients, 55 were included in the analysis...
March 2024: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
#27
JOURNAL ARTICLE
Amit Joshi, Nishchal Rijal, Subash Gurung, Bibek Basukala, Rajiv Sharma, Rohit Bista, Nagmani Singh, Ishor Pradhan
BACKGROUND: Although rare, deep vein thrombosis is a potentially life-threatening complication of knee arthroscopy. There are scanty literature analysing deep vein thrombosis after arthroscopy in Nepal. This study aimed to identify the prevalence of deep vein thrombosis in patients undergoing knee arthroscopy without chemoprophylaxis postoperatively at 2 weeks and 6 weeks, respectively. The study also aimed to estimate the risk of deep vein thrombosis in these patients by using Caprini Risk Assessment Model...
March 31, 2024: Journal of Nepal Health Research Council
#28
REVIEW
Kehong Xiang, Huan Xu, Yamei Zhang, Qiuju Leng, Feng Zhang
BACKGROUND: The study employed meta-analysis to provide a comprehensive synthesis of evidence regarding the association between the prothrombin A19911G polymorphism and the risk of venous thromboembolism (VTE). METHOD: The databases were searched to identify studies investigating the association between the prothrombin A19911G polymorphism and the risk of VTE. Meta-analysis was conducted using Stata 14.0 software. RESULTS: A total of five literature studies were included, involving 14,001 participants...
April 14, 2024: Phlebology
#29
REVIEW
Emdormi Rymbai, Deepa Sugumar, Amritha Chakkittukandiyil, Ram Kothandan, Divakar Selvaraj
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders. Pathologically, AD and PD are characterized by the accumulation of misfolded proteins. Hence, they are also called as proteinopathy diseases. Gender is considered as one of the risk factors in both diseases. Estrogens are widely accepted to be neuroprotective in several neurodegenerative disorders. Estrogens can be produced in the central nervous system, where they are called as neurosteroids. Estrogens mediate their neuroprotective action mainly through their actions on estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ)...
April 2024: Cell Biochemistry and Function
#30
JOURNAL ARTICLE
Sepsis and Septic Shock in Patients Undergoing Thyroidectomy: Incidence, Risk Factors, and Outcomes.
Usama Waqar, Namrah Aziz, Ahmad Areeb Chaudhry, Haissan Iftikhar, Nadia Jivani, Syed Akbar Abbas
INTRODUCTION: Postoperative sepsis represents a rare complication following thyroidectomy. We aimed to explore the incidence, risk factors, sources, and outcomes of postoperative sepsis and septic shock among adult patients undergoing thyroidectomy. METHODS: Data from the American College of Surgeons National Surgical Quality Improvement Program were used in this retrospective cohort study. Patients aged ≥18 y who underwent elective thyroidectomy between 2005 and 2019 were included...
April 13, 2024: Journal of Surgical Research
#31
JOURNAL ARTICLE
Asanthi M Ratnasekera, Sirivan S Seng, Daniel Kim, Wenyan Ji, Christina L Jacovides, Elinore J Kaufman, Hannah M Sadek, Lindsey L Perea, Christina Monaco Poloni, Ilya Shnaydman, Alexandra Jeongyoon Lee, Victoria Sharp, Angela Miciura, Eric Trevizo, Martin G Rosenthal, Lawrence Lottenberg, William Zhao, Alicia Keininger, Michele Hunt, John Cull, Chassidy Balentine, Tanya Egodage, Aleem T Mohamed, Michelle Kincaid, Stephanie Doris, Robert Cotterman, Sara Seegert, Lewis E Jacobson, Jamie Williams, Melissa Moncrief, Brandi Palmer, Caleb Mentzer, Nichole Tackett, Tjasa Hranjec, Thomas Dougherty, Shawna Morrissey, Lauren Donatelli-Seyler, Amy Rushing, Leah C Tatebe, Tiffany J Nevill, Michel B Aboutanos, David Hamilton, Diane Redmond, Daniel C Cullinane, Carolyne Falank, Mark McMellen, Chris Duran, Jennifer Daniels, Shana Ballow, Kevin M Schuster, Paula Ferrada
BACKGROUND: In patients with severe traumatic brain injury (TBI), clinicians must balance preventing venous thromboembolism (VTE) with the risk of intracranial hemorrhagic expansion (ICHE). We hypothesized that low molecular weight heparin (LMWH) would not increase risk of ICHE or VTE as compared to unfractionated heparin (UH) in patients with severe TBI. METHODS: Patients ≥ 18 years of age with isolated severe TBI (AIS ≥ 3), admitted to 24 level I and II trauma centers between January 1, 2014 to December 31, 2020 and who received subcutaneous UH and LMWH injections for chemical venous thromboembolism prophylaxis (VTEP) were included...
April 9, 2024: Injury
#32
REVIEW
Ruta Virsinskaite, Nina Karia, Tushar Kotecha, Benjamin E Schreiber, J Gerry Coghlan, Daniel S Knight
Pulmonary hypertension (PH) is common, with an estimated prevalence of approximately 1% that increases with age. Prompt and accurate diagnosis is key to institute timely and appropriate therapy to improve symptoms and prognosis. The international guidelines for the diagnosis and management of PH have recently been updated, with a lowering of the haemodynamic threshold for diagnosis to a mean pulmonary artery pressure >20 mmHg. New diagnostic algorithms and revised indications for screening in at-risk groups have been developed to facilitate early referral to specialist PH centres...
September 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#33
JOURNAL ARTICLE
James French, Keslin Greenwood
No abstract text is available yet for this article.
November 2023: Clinical Medicine: Journal of the Royal College of Physicians of London
#34
JOURNAL ARTICLE
Masato Saitoh, Takemi Kudo, Takao Watanabe
BACKGROUND: Among venous thromboembolism, pulmonary thromboembolism (PTE) is one of the most serious postoperative complications. Deep venous thrombosis (DVT) is the main cause. Considering the unknown prevalence of DVT and PTE in the postoperative period of cardiovascular surgery in Japan, we investigated the incidence in consecutive patients who underwent cardiovascular surgery. METHODS: A total of 225 patients who underwent cardiovascular surgery at four hospitals consented to participate in the study...
April 13, 2024: Asian Cardiovascular & Thoracic Annals
#35
JOURNAL ARTICLE
Mariya Cherenko, Natasha M Appelman-Dijkstra, Ana Luisa Priego-Zurita, N R Biermasz, Olaf Dekkers, F A Klok, Nicole Reisch, Anna Aulinas, Betina Biagetti, Salvatore Cannavo, Letizia Canu, Mario Detomas, France Devuyst, Henrik Falhammar, Richard A Feelders, Francesco Ferrau, F Gatto, Chiara Grasselli, Pepijn van Houten, Charlotte Hoybye, Andrea M Isidori, Aglaia Kyrilli, Paola Loli, Dominique Maiter, Elisabeth Dorothea Susanne Nowak, Rosario Pivonello, Oskar Ragnarsson, Rebecca V Steenaard, Nicole Unger, Annenienke C Van de Ven, Susan M Webb, Diego Yeste, S Faisal Ahmed, Alberto M Pereira
BACKGROUND: Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE). OBJECTIVE: To evaluate current management of new cases of CS with a focus on VTE and thromboprophylaxis. DESIGN AND METHODS: A survey was conducted within those that report in electronic reporting tool (e-REC) of The European Registries for Rare Endocrine Conditions (EuRRECa) and the involved main thematic groups (MTG's) of the European Reference Networks for Rare Endocrine Disorders (Endo-ERN) on new patients with CS from January 2021 until July 2022...
April 1, 2024: Endocrine Connections
#36
REVIEW
Nangorgo J Coulibaly, Mohammed H Elgouhari, Muhammad H Arshad, Muhammad Waqas, Hussain Shallwani, Hakeem J Shakir
Thromboembolism is a complication of neurointerventional procedures that requires patients to be placed under antiplatelet therapy. Current options for antiplatelet therapies have a delayed onset of action that prevents a rapid door to puncture transition for patents presenting in acute settings. Cangrelor (Kengreal, Chiesi, USA) is an intravenous P2Y12 platelet inhibitor approved in percutaneous coronary interventions that has an immediate onset of action and half-life between 2 and 6 min. Thus, the goal of this study is to report on the safety, effectiveness, and indications for using Cangrelor in neurointerventional procedures...
April 13, 2024: Interventional Neuroradiology
#37
JOURNAL ARTICLE
Friedrich Erhart, Georg Widhalm, Barbara Kiesel, Matthias Hackl, Andreas Diendorfer, Matthias Preusser, Karl Rössler, Johannes Thaler, Ingrid Pabinger, Cihan Ay, Julia Riedl
Patients with high-grade gliomas are at high risk of venous thromboembolism (VTE). MicroRNAs (miRNAs) are small non-coding RNAs with multiple roles in tumour biology, haemostasis and platelet function. Their association with VTE risk in high-grade glioma has not been comprehensively mapped so far. We thus conducted a nested case-control study within 152 patients with WHO grade IV glioma that had been part of a prospective cohort study on VTE risk factors. At inclusion a single blood draw was taken, and patients were thereafter followed for a maximum of 2 years...
April 2024: Journal of Cellular and Molecular Medicine
#38
JOURNAL ARTICLE
Kunwadee Phongpao, Nuttanan Pholngam, Daranee Chokchaichamnankit, Khanita Nuamsee, Rattanaporn Praneetponkang, Puey Ounjai, Kittiphong Paiboonsukwong, Panjaree Siwaponanan, Kovit Pattanapanyasat, Jisnuson Svasti, Chantragan Srisomsap, Churat Weeraphan, Pornthip Chaichompoo, Saovaros Svasti
Splenectomised β-thalassaemia/haemoglobin E (HbE) patients have increased levels of circulating microparticles or medium extra-cellular vesicles (mEVs). The splenectomised mEVs play important roles in thromboembolic complications in patients since they can induce platelet activation and endothelial cell dysfunction. However, a comprehensive understanding of the mechanism of mEV generation in thalassaemia disease has still not been reached. Thalassaemic mEVs are hypothesised to be generated from cellular oxidative stress in red blood cells (RBCs) and platelets...
April 12, 2024: British Journal of Haematology
#39
REVIEW
David Renaud, Alexander Höller, Miriam Michel
In cardiology, acetylsalicylic acid (ASA) and warfarin are among the most commonly used prophylactic therapies against thromboembolic events. Drug-drug interactions are generally well-known. Less known are the drug-nutrient interactions (DNIs), impeding drug absorption and altering micronutritional status. ASA and warfarin might influence the micronutritional status of patients through different mechanisms such as binding or modification of binding properties of ligands, absorption, transport, cellular use or concentration, or excretion...
March 26, 2024: Nutrients
#40
JOURNAL ARTICLE
Marousa Kouvela, Maria Effrosyni Livanou, Dimitra T Stefanou, Ioannis A Vathiotis, Fotini Sarropoulou, Maria Grammoustianou, Evangelos Dimakakos, Nikolaos Syrigos
BACKGROUND: The aim of this study was to record and assess the efficacy and safety ofthromboprophylaxis with an intermediate dose of Tinzaparin in lung cancer patients with high thrombotic risk. METHODS: This was a non-interventional, single-arm, prospective cohort study of lung cancer patients who received thromboprophylaxis with Tinzaparin 10.000 Anti-Xa IU in 0.5 mL, OD, used in current clinical practice. Enrolled ambulatory patients signed informed consent. Anti-Xa levels were tested...
April 8, 2024: Cancers
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