keyword
MENU ▼
Read by QxMD icon Read
search

Insulin and atherosclerosis

keyword
https://www.readbyqxmd.com/read/29242557/the-metabolic-syndrome-associated-small-g-protein-arl15-plays-a-role-in-adipocyte-differentiation-and-adiponectin-secretion
#1
Nuno Rocha, Felicity Payne, Isabel Huang-Doran, Alison Sleigh, Katherine Fawcett, Claire Adams, Anna Stears, Vladimir Saudek, Stephen O'Rahilly, Inês Barroso, Robert K Semple
Common genetic variants at the ARL15 locus are associated with plasma adiponectin, insulin and HDL cholesterol concentrations, obesity, and coronary atherosclerosis. The ARL15 gene encodes a small GTP-binding protein whose function is currently unknown. In this study adipocyte-autonomous roles for ARL15 were investigated using conditional knockdown of Arl15 in murine 3T3-L1 (pre)adipocytes. Arl15 knockdown in differentiated adipocytes impaired adiponectin secretion but not adipsin secretion or insulin action, while in preadipocytes it impaired adipogenesis...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228671/metformin-ameliorates-skeletal-muscle-insulin-resistance-by-inhibiting-mir-21-expression-in-a-high-fat-dietary-rat-model
#2
Jinyang Wang, Yanbin Gao, Lijun Duan, Suhong Wei, Jing Liu, Liming Tian, Jinxing Quan, Qi Zhang, Juxiang Liu, Jinkui Yang
Insulin resistance (IR) plays a major role in the pathogenesis of abdominal obesity, hypertension, coronary heart disease, atherosclerosis and diabetes. miR-21 and TGF-β/smads is closely related to IR. However, it remained elusive whether metformin improved skeletal muscle insulin resistance (IRSM) by regulating miR-21 and its target signal TGF-β1/smads expression. In this study, high-fat diet rats with IR model and IR-skeletal muscle L6 cells (L6-SMCs) model were established, insulin sensitive index (ISI) and Homeostasis model assessment of IR (HOMA-IR) were applied, miR-21 and TGF-β1/smads mRNA expression were examined by RT-PCR, smad3 and smad7 protein were detected by western-blotting and laser scanning confocal microscopy (LSCM), the valid target of miR-21 was detected by luciferase reporter gene assay...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29225158/exendin-4-partly-ameliorates-of-hyperglycemia-mediated-tissue-damage-in-lungs-of-streptozotocin-induced-diabetic-mice
#3
Fusun Oztay, Serap Sancar Bas, Selda Gezginci-Oktayoglu, Merve Ercin, Sehnaz Bolkent
Glucagon-like peptide-1 (GLP-1) stimulates insulin secretion, and plays anti-inflammatory role in atherosclerosis, and has surfactant-releasing effects in lungs. GLP-1 analogues are used in diabetes therapy. This is the first study to investigate the effects of exendin-4, a GLP-1 receptor agonist, on lung injury in diabetic mice. BALB/c male mice were divided into four groups. The first group was given only citrate buffer, the second group was given only exendin-4, the third group was given only streptozotocin (STZ), and the fourth group was given both exendin-4 and STZ...
December 7, 2017: Peptides
https://www.readbyqxmd.com/read/29222957/association-between-%C3%AE-cell-function-estimated-by-homa-%C3%AE-and-prognosis-of-nondiabetic-patients-with-ischaemic-stroke
#4
Mengyuan Zhou, Yuesong Pan, Jing Jing, Yongjun Wang, Xingquan Zhao, Liping Liu, Hao Li, Yilong Wang
BACKGROUND AND PURPOSE: Studies showed β-cell dysfunction was associated with increased risk of cardiovascular disease and subclinical carotid atherosclerosis. This study aimed to investigate the association between β-cell function and prognosis of nondiabetic patients with ischaemic stroke. METHODS: Ischaemic stroke patients without diabetes in the Abnormal Glucose Regulation in Patients with Acute Stroke across China registry were included in this analysis. Homeostasis assessment of β-cell function (HOMA-β), was performed and classified it into four groups according to quartiles...
December 9, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29222858/obesity-lipid-profiles-and-oxidative-stress-in-children-after-liver-transplantation
#5
Piotr Czubkowski, Aldona Wierzbicka, Joanna Pawłowska, Irena Jankowska, Piotr Socha
PURPOSE: In adult liver transplant recipients, coronary artery disease and congestive heart failure are significant cause of morbidity and mortality. This may be attributed to the long-term immunosuppressive treatment, mostly with calcineurin inhibitors and steroids, which in long-term may be associated with hyperlipidemia, oxidative stress and cardiovascular complications. Since such data for children is sparse, the aim of this study was to assess the lipid and oxidative stress markers after pediatric liver transplantation (LTx)...
December 10, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29222856/homocysteine-as-a-non-classical-risk-factor-for-atherosclerosis-in-relation-to-pharmacotherapy-of-type-2-diabetes-mellitus
#6
Magdalena Borowska, Marzena Dworacka, Hanna Winiarska, Ewa Krzyżagórska
AIMS: The aim of our study was to evaluate which of the pharmacotherapeutic methods that are frequently used to treat type 2 diabetes is associated with the most beneficial profile in relation to pro-atherogenic homocysteine levels. PATIENTS AND METHODS: We measured the serum homocysteine level in 182 patients with type 2 diabetes treated with metformin (89), treated with insulin in combination with metformin (31), receiving sulfonylureas (31) and treated conventionally with insulin (31)...
December 7, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29220092/dose-rectification-of-an-unbalance-between-dpp4-and-glp-1-ameliorates-chronic-stress-related-vascular-aging-and-atherosclerosis
#7
Xian Wu Cheng, Megumi Narisawa, Enze Jin, Chenglin Yu, Wenhu Xu, Limei Piao
Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging and regeneration. Dipeptidyl peptidase-4 (DPP-4) exerts many physiological and pharmacological functions by regulating its extremely abundant substrates [e.g., glucagon-like peptide-1 (GLP-1), stromal cell-derived factor-1α/ C-X-C chemokine receptor type-4, etc.]. Over the past decade, emerging data revealed unexpected roles for DPP-4 and GLP-1 in intracellular signaling, oxidative stress production, lipid metabolism, cell apoptosis, immune activation, insulin resistance, and inflammation...
December 8, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29215061/local-production-of-activated-factor-x-in-atherosclerotic-plaque-induced-vascular-smooth-muscle-cell-senescence
#8
Fumihiro Sanada, Jun Muratsu, Rei Otsu, Hideo Shimizu, Nobutaka Koibuchi, Kazutaka Uchida, Yoshiaki Taniyama, Shinichi Yoshimura, Hiromi Rakugi, Ryuichi Morishita
Our previous study demonstrated that coagulation factor Xa (FXa) induced endothelial cell senescence, resulting in inflammation and impaired angiogenesis. This mechanism is dictated through protease-activated receptors, PARs, insulin-like growth factor-binding protein 5 (IGFBP-5), and p53. Activation of PARs contributes to the pathophysiology of several chronic inflammatory diseases, including atherosclerosis. Thus, we speculated that similar mechanism might participate in the progression of atherosclerotic plaques...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29213335/liraglutide-attenuates-atherosclerosis-via-inhibiting-er-induced-macrophage-derived-microvesicles-production-in-t2dm-rats
#9
Jinjin Li, Xiaojuan Liu, Qianhua Fang, Min Ding, Chunjun Li
Background: We investigated the effects of liraglutide on the formation and progression of atherosclerosis in type 2 diabetes mellitus (T2DM) rats. Methods: Sprague-Dawley rats were divided into control group, diabetes group and liraglutide treated group. The T2DM rats model with atherosclerosis were induced by high fat diet followed small dosage streptozotocin injection. Body weight and blood glucose levels were monitored once a week for 3 months and then the rats were sacrificed...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29212583/effect-of-caloric-restriction-on-metabolic-dysfunction-of-young-rapacz-familial-hypercholesterolemic-swine-sus-scrofa
#10
Nell A Bekiares, Andrea S Chen, Dhanansayan Shanmuganayagam, Adrienne Dardenne Meyers, Thomas D Crenshaw, Christian G Krueger, Jess D Reed
The Rapacz familial hypercholesterolemic (FH) swine model is well-characterized and used for studies of both spontaneous and inducible atherosclerosis but has not been used for studies of metabolic dysfunction to date. We examined whether parameters of metabolic syndrome including weight and adiposity, serum cholesterol, and glucoregulatory function could be modulated by restriction of caloric intake in the FH swine. Three groups of FH swine (n = 6 per group) were fed without restriction (AL), 80% of AL caloric intake, or 60% of AL caloric intake for 8...
December 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/29205099/adiponectin-leptin-ratio-a-promising-index-to-estimate-adipose-tissue-dysfunction-relation-with-obesity-associated-cardiometabolic-risk
#11
Gema Frühbeck, Victoria Catalán, Amaia Rodríguez, Javier Gómez-Ambrosi
Obesity is currently the most extended metabolic disturbance worldwide favoring the development of cardiometabolic alterations such as type 2 diabetes, hypertension, and dyslipidemia. Obesity and the metabolic syndrome (MS) are characterized by an increase in circulating leptin concentrations, in parallel to a decrease in blood levels of adiponectin. Consequently, the adiponectin/leptin ratio has been suggested as a maker of adipose tissue dysfunction. This emerging biomarker correlates with insulin resistance better than adiponectin or leptin alone, or even HOMA and is decreased with increasing number of metabolic risk factors having been proposed as a predictive marker for the MS...
December 5, 2017: Adipocyte
https://www.readbyqxmd.com/read/29203734/effect-of-pioglitazone-on-insulin-resistance-progression-of-atherosclerosis-and-clinical-course-of-coronary-heart-disease
#12
Olha V Skochko, Igor P Kaidashev
INTRODUCTION: Pioglitazone, a medication of thiazolidinedione group, is capable of triggering the peroxisome proliferator-activated receptors (PPAR-γ). Activation of receptor PPAR-γ regulates carbohydrate and lipid metabolism, immune and inflammatory responses in heart tissues. THE AIM: Our aim was to study the effect of pioglitazone on insulin resistance, the clinical course of atherosclerosis and coronary heart disease (CHD). MATERIALS AND METHODS: The study included 43 patients with coronary artery disease...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29201918/the-role-of-insulin-receptor-isoforms-in-diabetes-and-its-metabolic-and-vascular-complications
#13
REVIEW
O Escribano, N Beneit, C Rubio-Longás, A R López-Pastor, A Gómez-Hernández
The insulin receptor (IR) presents by alternative splicing two isoforms: IRA and IRB. The differential physiological and pathological role of both isoforms is not completely known, and it is determinant the different binding affinity for insulin-like growth factor. IRB is more abundant in adult tissues and it exerts mainly the metabolic actions of insulin, whereas IRA is mainly expressed in fetal and prenatal period and exerts mitogenic actions. However, the change in the expression profile of both IR isoforms and its dysregulation are associated with the development of different pathologies, such as cancer, insulin resistance, diabetes, obesity, and atherosclerosis...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29200598/vitamin-d-status-disease-activity-and-endothelial-dysfunction-in-early-rheumatoid-arthritis-patients
#14
Alexandru Caraba, Viorica Crişan, Ioan Romoşan, Ioana Mozoş, Marius Murariu
Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction...
2017: Disease Markers
https://www.readbyqxmd.com/read/29191923/sortilin-and-its-multiple-roles-in-cardiovascular-and-metabolic-diseases
#15
REVIEW
Claudia Goettsch, Mads Kjolby, Elena Aikawa
Cardiovascular disease is a leading cause of morbidity and mortality in the Western world. Studies of sortilin's influence on cardiovascular and metabolic diseases goes far beyond the genome-wide association studies that have revealed an association between cardiovascular diseases and the 1p13 locus that encodes sortilin. Emerging evidence suggests a significant role of sortilin in the pathogenesis of vascular and metabolic diseases. This includes type II diabetes mellitus via regulation of insulin resistance, atherosclerosis through arterial wall inflammation and calcification, and dysregulated lipoprotein metabolism...
November 30, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29189176/the-emerging-role-of-complement-c3-as-a-biomarker-of-insulin-resistance-and-cardiometabolic-diseases-preclinical-and-clinical-evidence
#16
Francesco Ursini, Ludovico Abenavoli
BACKGROUND: An intricate network of reciprocal interactions between adipose tissue and immune system have been largely demonstrated, leading to the well-accepted concept of insulin resistance as a low grade inflammatory state and, conversely, chronic high-grade inflammation as a dysmetabolic condition. Immune homeostasis is regulated by several players including the complement system, a complex protein network at the crossroad between the innate and adaptive arms of the human defences against pathogens...
November 28, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/29178545/genome-wide-study-of-subcutaneous-and-visceral-adipose-tissue-reveals-novel-sex-specific-adiposity-loci-in-mexican-americans
#17
Chuan Gao, Carl D Langefeld, Julie T Ziegler, Kent D Taylor, Jill M Norris, Yii-Der I Chen, Jacklyn N Hellwege, Xiuqing Guo, Matthew A Allison, Elizabeth K Speliotes, Jerome I Rotter, Donald W Bowden, Lynne E Wagenknecht, Nicholette D Palmer
OBJECTIVE: This study aimed to explore the genetic mechanisms of regional fat deposition, which is a strong risk factor for metabolic diseases beyond total adiposity. METHODS: A genome-wide association study of 7,757,139 single-nucleotide polymorphisms (SNPs) in 983 Mexican Americans (nmale  = 403; nfemale  = 580) from the Insulin Resistance Atherosclerosis Family Study was performed. Association analyses were performed with and without sex stratification for subcutaneous adipose tissue, visceral adipose tissue (VAT), and visceral-subcutaneous ratio (VSR) obtained from computed tomography...
November 27, 2017: Obesity
https://www.readbyqxmd.com/read/29177258/is-18f-fdg-pet-ct-a-valuable-diagnostic-tool-for-verifying-accelerated-atherosclerosis-secondary-to-diabetes-mellitus-on-insulin-in-the-aortic-segments-and-large-arteries
#18
Gonca G Bural, Drew A Torigian, Mohamed Houseni, Kaan M Sözmen, Abass Alavi
OBJECTIVE: Fluorine-18 fluorodeoxylglucose positron emission tomography/computed tomography (18F-FDG PET/CT) has a well-established role for detection and quantification of atherosclerotic inflammatory disease using standardized uptake value (SUV) measurements. Our aim was to compare the inflammatory and macroscopic calcification processes of atherosclerosis in the aortic segments and large arteries of subjects with insulin dependent diametes mellitus (IDDM) compared to those of age-matched controls via 18F-FDG PET/CT...
November 27, 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29170152/impact-of-lipid-measurements-in-youth-in-addition-to-conventional-clinic-based-risk-factors-on-predicting-preclinical-atherosclerosis-in-adulthood-the-international-childhood-cardiovascular-cohort-i3c-consortium
#19
Juha Koskinen, Markus Juonala, Terence Dwyer, Alison Venn, Russell Thomson, Lydia Bazzano, Gerald S Berenson, Matthew A Sabin, Trudy L Burns, Jorma S A Viikari, Jessica G Woo, Elaine M Urbina, Ronald Prineas, Nina Hutri-Kähönen, Alan Sinaiko, David Jacobs, Julia Steinberger, Stephen Daniels, Olli T Raitakari, Costan G Magnussen
Background -Data suggest that the prediction of adult cardiovascular disease using a model comprised entirely of adult non-laboratory based risk factors is equivalent to an approach that additionally incorporates adult lipid measures. We assessed and compared the utility of a risk model based solely on non-laboratory risk factors in adolescence vs. a lipid model based on non-laboratory risk factors + lipids for predicting high-risk carotid intima-media thickness (cIMT) in adulthood. Methods -The study comprised 2,893 participants aged 12-18 years from four longitudinal cohort studies from the United States (Bogalusa Heart Study and the Insulin Study), Australia (Childhood Determinants of Adult Health Study) and Finland (The Cardiovascular Risk in Young Finns Study) and followed into adulthood when cIMT was measured (mean follow-up 23...
November 23, 2017: Circulation
https://www.readbyqxmd.com/read/29168363/free-estradiol-index-levels-associated-with-high-sensitivity-crp-levels-in-male-children
#20
Mehmet Ağırbaşlı, Azra Tanrıkulu, Munir Azizy
Ağırbaşlı M, Tanrıkulu A, Azizy M. Free estradiol index levels associated with high sensitivitiy CRP levels in male children. Turk J Pediatr 2017; 59: 49-55. Biomarkers of inflammation such as high-sensitivity C-reactive protein (hs-CRP) associate with subclinical atherosclerosis. Atherosclerosis is an early onset disease in life. Sex hormones and puberty modulate metabolism in children. Studies indicate that low sex hormone binding globulin (SHBG) levels associate with insulin resistance and metabolic syndrome in children...
2017: Turkish Journal of Pediatrics
keyword
keyword
83341
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"