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https://www.readbyqxmd.com/read/29656281/treatment-of-very-small-de-novo-coronary-artery-disease-with-2-0-mm-drug-coated-balloons-showed-1-year-clinical-outcome-comparable-with-2-0-mm-drug-eluting-stents
#1
Hui Wen Sim, Rajiv Ananthakrishna, Siew Pang Chan, Adrian F Low, Chi-Hang Lee, Mark Y Chan, Edgar L Tay, Poay Huan Loh, Koo Hui Chan, Huay Cheem Tan, Joshua P Loh
OBJECTIVE: To evaluate the 1-year clinical outcomes of patients treated with 2.0 mm drug-coated balloon (DCB) vs 2.0 mm drug-eluting stent (DES) implantation in small-caliber vessel de novo coronary artery disease (CAD). METHODS: All patients treated with 2.0 mm DCB or 2.0 mm DES for very small vessel de novo CAD from July 2014 to June 2016 were included in this study. The primary endpoint was the occurrence of target-lesion failure (TLF) and time to TLF, defined as a combination of cardiac mortality, target-vessel myocardial infarction, and target-lesion revascularization (TLR)...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29656279/drug-eluting-resorbable-magnesium-scaffold-implantation-in-st-segment-elevation-myocardial-infarction-a-pilot-study
#2
Quentin de Hemptinne, Fabien Picard, Rachid Briki, Ahmad Awada, Paul-Gaël Silance, Dariouch Dolatabadi, Nadia Debbas, Philippe Unger
OBJECTIVES: To assess feasibility and short-term clinical outcomes associated with resorbable magnesium scaffold (RMS) implantation in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). BACKGROUND: RMS implantation has demonstrated favorable clinical outcomes in stable coronary artery disease patients. However, to date, data are lacking in the setting of STEMI. METHODS: This is a single-center prospective non-randomized pilot study...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29655953/risk-factors-predisposing-to-acute-coronary-syndromes-in-young-women-%C3%A2-45-years-of-age
#3
Maciej Bęćkowski, Marek Gierlotka, Mariusz Gąsior, Lech Poloński, Tomasz Zdrojewski, Rafał Dąbrowski, Jarosław Karwowski, Ilona Kowalik, Wojciech Drygas, Hanna Szwed
BACKGROUND: Acute coronary syndromes (ACS) are rare in young women. The purpose of this study was to characterize risk factors (RF) predisposing to ACS in young women and evaluate possible age-related differences. METHODS AND RESULTS: We studied 1941 young women with ACS aged ≤45 years (≤45ACS) from the PL-ACS registry and compared them with two control groups: 4275 women aged 63-64 years with ACS (63-64ACS) from the PL-ACS registry and 1170 young healthy women aged ≤45 years (≤45H) without confirmed coronary artery disease (CAD), from two national, representative, cross-sectional population health surveys, NATPOL 2011 and WOBASZ...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655952/population-level-incidence-and-outcomes-of-myocardial-infarction-with-non-obstructive-coronary-arteries-minoca-insights-from-the-alberta-contemporary-acute-coronary-syndrome-patients-invasive-treatment-strategies-coapt-study
#4
Kevin R Bainey, Robert C Welsh, Wendimagegn Alemayehu, Cynthia M Westerhout, Dean Traboulsi, Todd Anderson, Neil Brass, Paul W Armstrong, Padma Kaul
BACKGROUND: Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a known clinical conundrum with limited investigation. Using a large population-based cohort, we examined the incidence, demographic profile, use of evidence-based medicines (EBM) and clinical outcomes of MINOCA patients. METHODS: Patients hospitalized with a primary diagnosis of MI who underwent coronary angiography between 01/04/2002 and 31/03/2014 in Alberta, Canada, were included in the study...
April 4, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655951/acef-score-adapted-to-st-elevation-myocardial-infarction-patients-the-acef-stemi-score
#5
Martin Reindl, Sebastian Johannes Reinstadler, Christina Tiller, Markus Kofler, Markus Theurl, Nora Klier, Katherina Fleischmann, Agnes Mayr, Benjamin Henninger, Gert Klug, Bernhard Metzler
BACKGROUND: The age, creatinine and ejection fraction (ACEF) score has originally been developed for risk stratification of patients undergoing elective cardiac surgery. In patients with stable coronary artery disease treated by percutaneous coronary intervention (PCI), the prognostic accuracy of ACEF could be further improved by modifying the original scoring system (called "modified ACEF" or "ACEF-MDRD"). We aimed to specifically adapt the ACEF score for risk assessment of ST-elevation myocardial infarction (STEMI) patients...
April 6, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29655767/correction-in-article-by-vaglimi-et-al-2017-esc-focused-update-on-dual-antiplatelet-therapy-in-coronary-artery-disease-developed-in-collaboration-with-eacts-rev-esp-cardiol-2018-71-42-e1-e58
#6
(no author information available yet)
No abstract text is available yet for this article.
April 11, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29655684/protective-role-and-mechanism-of-snakegourd-peel-against-myocardial-infarction-in-rats
#7
Guanlin Yang, Dongyu Min, Junwei Yan, Ming Yang, Guijun Lin
BACKGROUND: Injection of snakegourd peel (SP), an herb used in traditional Chinese medicine, is used to treat coronary artery disease and stable angina in China. However, its therapeutic role and mechanism of action for the treatment of myocardial infarction (MI) is not fully understood. PURPOSE: The present study was designed to investigate the effect of SP on MI-induced cardiac injury and elucidate its underlying molecular mechanisms. METHODS: To create an in vivo model of MI, we ligated the left coronary artery of Wistar rats...
March 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29655653/increased-risk-of-cardiovascular-disease-in-women-with-prior-gestational-diabetes-a-systematic-review-and-meta-analysis
#8
Jing Li, Chunhua Song, Changping Li, Ping Liu, Zhuoyu Sun, Xilin Yang
This study aims to investigate the effect of gestational diabetes mellitus (GDM) on the long-term risk of cardiovascular disease (CVD). PubMed and other databases were searched up to August 31, 2017. Cohort studies evaluating risk of CVD postpartum in women with and without prior GDM were included. Random-effect model was used to estimate the pooled relative risk of CVD. Sensitivity and subgroup analyses were performed to check the consistency of the effect size and to explore sources of heterogeneity. Multivariable logistic regression was used to control for high heterogeneity...
April 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29655567/acute-coronary-syndrome-relationship-between-genetic-variants-and-timi-risk
#9
Viviane do Carmo Vasconcelos de Carvalho, Lílian Caroliny Amorim Silva, Romário Martins Araújo, Fábia Carla da Silva Soares, Maria José Ribeiro Bezerra, Sávio Augusto Vieira de Oliveira, Alex José de Melo Silva, Sérgio Tavares Montenegro, Roberto Pereira Werkhauser, Carlos Gustavo Régis da Silva, Adriana Vieira Gomes, Clarice Neuenschwander Lins de Morais, Silvia Maria Lucena Montenegro
Acute Coronary Syndrome (ACS) is a multifactorial disease, including the genetic factor, caused by coronary artery obstruction by atheroma. Some genetic variants have been described as risk factors for this disease. Its early diagnosis and stratification of risk of death by Thrombolysis in Myocardial Infarction (TIMI) are important. Therefore, we evaluated variants in the IL6R (c950-1722C>T), TNFa (c.-488G>A), LEPR (c.2673+1118C>T) and IL1b (c.-598T>C) genes in relation to TIMI risk, cytokine serum levels, and risk factors for ACS...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29653075/inhibition-of-semicarbazide-sensitive-amine-oxidase-reduces-atherosclerosis-in-apolipoprotein-e-deficient-mice
#10
Shu-Huei Wang, Tse-Ya Yu, Feng-Chiao Tsai, Chris J Weston, Mao-Shin Lin, Chi-Sheng Hung, Hsien-Li Kao, Yu-I Li, Montse Solé, Mercedes Unzeta, Yuh-Lien Chen, Lee-Ming Chuang, Hung-Yuan Li
Inflammation, oxidative stress, and formation of advanced glycated end products (AGEs) and advanced lipoxidation end products (ALEs) are important for atherosclerosis. Vascular adhesion protein-1 (VAP-1) participates in inflammation and has semicarbazide-sensitive amine oxidase (SSAO) activity, which catalyzes oxidative deamination to produce hydrogen peroxide and aldehydes, leading to generation of AGEs and ALEs. However, the effect of VAP-1/SSAO inhibition on atherosclerosis remains controversial, and no studies used coronary angiography to evaluate if plasma VAP-1/SSAO is a biomarker for coronary artery disease (CAD)...
March 27, 2018: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29652832/sympathetic-nerve-hyperactivity-in-the-spleen-causal-for-nonpathogenic-driven-chronic-immune-mediated-inflammatory-diseases-imids
#11
REVIEW
Denise L Bellinger, Dianne Lorton
Immune-Mediated Inflammatory Diseases (IMIDs) is a descriptive term coined for an eclectic group of diseases or conditions that share common inflammatory pathways, and for which there is no definitive etiology. IMIDs affect the elderly most severely, with many older individuals having two or more IMIDs. These diseases include, but are not limited to, type-1 diabetes, obesity, hypertension, chronic pulmonary disease, coronary heart disease, inflammatory bowel disease, and autoimmunity, such as rheumatoid arthritis (RA), Sjőgren's syndrome, systemic lupus erythematosus, psoriasis, psoriatic arthritis, and multiple sclerosis...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29652747/the-incremental-clinical-value-of-cardiac-hybrid-spect-cta-imaging-in-coronary-artery-disease
#12
Lin Qiu, Hui Tan, Dengfeng Cheng, Hongcheng Shi
Coronary artery disease (CAD) is a major cause of death worldwide. It is significantly important to assess the coronary lesion and its pathophysiological relevance comprehensively. Coronary computed tomography angiography (CTA) or myocardial perfusion imaging alone suffers from some limitations in the evaluation of CAD. Through the integration and spatial colocalization of complementary morphological and functional information, the results of published hybrid single-photon emission computed tomography (SPECT)/CTA studies in patients with CAD are promising for detecting functionally relevant coronary artery lesion and evaluating the relationship between diseased coronary artery, coronary artery anomaly, myocardial bridging, or coronary calcification and myocardial ischemia...
April 12, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29652673/inflammation-and-coronary-artery-disease-from-pathophysiology-to-canakinumab-anti-inflammatory-thrombosis-outcomes-study-cantos
#13
Mahboob Ali, Sameh Girgis, Atif Hassan, Steven Rudick, Richard C Becker
The worldwide prevalence of cardiovascular disease in general and atherosclerotic coronary artery disease in particular is a health and economic concern of unparalleled proportion. Despite a long history of astute observations beginning in 1575 made by Fallopius, followed by those of von Rokatansky, Virchow, Osler, and Ross, and incremental knowledge of the pathobiology of atherosclerosis to include varying stages of inflammation, response to internally and externally mediated vascular injury, and impaired homeostasis, gaps in the field's understanding persist...
April 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29652662/sialylated-isoforms-of-apolipoprotein-c-iii-and-plasma-lipids-in-subjects-with-coronary-artery-disease
#14
Oliviero Olivieri, Carmela Chiariello, Nicola Martinelli, Annalisa Castagna, Giulia Speziali, Domenico Girelli, Francesca Pizzolo, Antonella Bassi, Daniela Cecconi, Elisa Robotti, Marcello Manfredi, Eleonora Conte, Emilio Marengo
BACKGROUND: Apolipoprotein C-III (ApoC-III), a key regulator of plasma triglyceride (TG), is present in three isoforms, i.e. non-sialylated (ApoC-III0), monosialylated (ApoC-III1) and disialylated (ApoC-III2). We aimed at quantifying the distribution of the ApoC-III glycoforms in patients with angiographically demonstrated coronary artery disease (CAD) according to levels of total ApoC-III plasma concentration. METHODS: ApoC-III glycoforms were quantified by a specifically developed, high-resolution, mass spectrometry method in unrelated CAD patients...
April 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29652543/cardioprotection-by-intermittent-hypoxia-conditioning-evidence-mechanisms-and-therapeutic-potential
#15
Robert T Mallet, Eugenia B Manukhina, Steven S Ruelas, James L Caffrey, H Fred Downey
The calibrated application of limited duration, cyclic, moderately intense hypoxia-reoxygenation increases cardiac resistance to ischemia-reperfusion stress. These intermittent hypoxic conditioning (IHC) programs consistently produce striking reductions in myocardial infarction and ventricular tachyarrhythmias following coronary artery occlusion and reperfusion, and in many cases, improved contractile function and coronary blood flow. These IHC protocols are fundamentally different from those used to simulate sleep apnea, a recognized cardiovascular risk factor...
April 13, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29652272/comparison-of-immediate-extubation-versus-ultrafast-tracking-strategy-in-the-management-of-off-pump-coronary-artery-bypass-surgery
#16
Amarja Sachin Nagre, Nagesh P Jambures
Introduction: Ultrafast tracking of anesthesia (UFTA) is practiced routinely, whereas immediate on-table extubation after off-pump coronary artery bypass (OPCAB) grafting surgery has many concerns. The purpose of our study was to evaluate the safety and feasibility of immediate extubation (IE) versus UFTA. Methods: Sixty patients were enrolled who underwent OPCAB surgery. The two groups IE and UFTA had thirty patients each. Inclusion criteria were patients for OPCAB surgery including left main stenosis...
April 2018: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/29652166/ambulance-use-distance-and-outcomes-in-patients-with-suspected-cardiovascular-disease-a-registry-based-geographic-information-system-study
#17
Nariman Sepehrvand, Wendimagegn Alemayehu, Padma Kaul, Rick Pelletier, Aminu K Bello, Robert C Welsh, Paul W Armstrong, Justin A Ezekowitz
BACKGROUND: Despite guideline recommendations, the majority of patients with symptoms suggestive of acute coronary syndrome do not use emergency medical services to reach the emergency department (ED). The aim of this study was to investigate the factors associated with EMS utilisation and subsequent patient outcomes. METHODS: Using administrative data, all patients who presented to an ED in the metropolitan areas of Edmonton and Calgary in the years of 2007-2013 with main ED diagnosis of acute coronary syndrome, stable angina or chest pain were included...
April 1, 2018: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/29652078/total-cardiovascular-events-analysis-of-the-examine-trial-in-patients-with-type-2-diabetes-and-recent-acute-coronary-syndrome
#18
Matthew A Cavender, William B White, Yuyin Liu, Joseph M Massaro, Richard M Bergenstal, Cyrus R Mehta, Faiez Zannad, Simon Heller, William C Cushman, Christopher P Cannon
BACKGROUND: Alogliptin, a dipeptidyl-peptidase 4 inhibitor, is approved for the treatment of patients with type 2 diabetes. EXAMINE was a randomized-controlled clinical trial designed to demonstrate the cardiovascular safety of alogliptin. In the trial, 5380 patients with established T2DM who had a recent ACS event (between 15-90 days) were randomized to treatment with either alogliptin or placebo. HYPOTHESIS: To better understand and describe the cardiovascular (CV) safety of alogliptin, we analyzed data from the EXAMINE randomized clinical trial to determine whether treatment with alogliptin affected recurrent and total CV events...
April 13, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29652077/the-implications-of-cocaine-use-and-associated-behaviors-on-adverse-cv-outcomes-among-veterans-insights-from-the-va-clinical-assessment-reporting-and-tracking-cart-program
#19
Ateka Gunja, Maggie A Stanislawski, Anna E Barón, Thomas M Maddox, Steven M Bradley, Mladen I Vidovich
BACKGROUND: Cocaine use has been associated with adverse cardiovascular outcomes in patients with coronary artery disease. It is unclear if this association is due to direct effects of cocaine or other factors. METHODS: The Veterans Affairs cardiac catheterization database was used to identify Veterans undergoing coronary catheterization between 2007 and 2014. We analyzed association between cocaine use and 1-year all-cause mortality, myocardial infarction (MI), and cerebrovascular accident (CVA) among Veterans with obstructive CAD (N=122,035)...
April 13, 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29652038/analysis-of-novel-cardiovascular-biomarkers-in-patients-with-peripheral-artery-disease-pad
#20
Peter Jirak, Moritz Mirna, Bernhard Wernly, Vera Paar, Marcus Thieme, Stefan Betge, Marcus Franz, Uta Hoppe, Alexander Lauten, Jürgen Kammler, Paul C Schulze, Michael Lichtenauer, Daniel Kretzschmar
BACKGROUND: Peripheral artery disease (PAD) is a common form of manifestation of atherosclerosis. PAD has a considerable impact on morbidity, hospitalisation rates and health- care costs. Biomarkers have been introduced in many cardiovascular disease entities over the last years. However, an analysis on the correlation of biomarker levels and PAD is still lacking. METHODS: A total of 106 patients were enrolled in this current study, 51 that were diagnosed with PAD and 55 with excluded coronary and peripheral artery disease as controls...
April 12, 2018: Minerva Medica
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