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https://www.readbyqxmd.com/read/28829900/analysis-of-p53-gene-polymorphism-codon-72-in-symptomatic-patients-with-atherosclerosis
#1
M H Lagares, K S F Silva, A M Barbosa, D A Rodrigues, I R Costa, J V M Martins, M P Morais, F L Campedelli, K K V O Moura
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may block blood flow in loco, or even leading to obstruction of other vessels with a smaller diameter. This process is one of the main determinants of the clinical manifestations of atherosclerosis, such as coronary artery disease, ischemic stroke, and peripheral arterial disease...
August 17, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28829817/genomic-correlates-of-glatiramer-acetate-adverse-cardiovascular-effects-lead-to-a-novel-locus-mediating-coronary-risk
#2
Ingrid Brænne, Lingyao Zeng, Christina Willenborg, Vinicius Tragante, Thorsten Kessler, Cristen J Willer, Markku Laakso, Lars Wallentin, Paul W Franks, Veikko Salomaa, Abbas Dehghan, Thomas Meitinger, Nilesh J Samani, Folkert W Asselbergs, Jeanette Erdmann, Heribert Schunkert
Glatiramer acetate is used therapeutically in multiple sclerosis but also known for adverse effects including elevated coronary artery disease (CAD) risk. The mechanisms underlying the cardiovascular side effects of the medication are unclear. Here, we made use of the chromosomal variation in the genes that are known to be affected by glatiramer treatment. Focusing on genes and gene products reported by drug-gene interaction database to interact with glatiramer acetate we explored a large meta-analysis on CAD genome-wide association studies aiming firstly, to investigate whether variants in these genes also affect cardiovascular risk and secondly, to identify new CAD risk genes...
2017: PloS One
https://www.readbyqxmd.com/read/28829745/everolimus-eluting-bioresorbable-scaffolds-in-patients-with-coronary-artery-disease-results-from-the-german-austrian-absorb-registry-gabi-r
#3
Holger M Nef, Jens Wiebe, Johannes Kastner, Julinda Mehilli, Thomas Münzel, Christoph Naber, Till Neumann, Gert Richardt, Axel Schmermund, Jochen Wöhrle, Ralf Zahn, Thomas Riemer, Stephan Achenbach, Christian W Hamm
AIMS: To analyze procedural results and mid-term safety of everolimus-eluting bioresorbable vascular scaffolds (BVS) used for percutaneous coronary intervention in a large all-comer cohort from the German-Austrian ABSORB Registry (GABI-R). METHODS AND RESULTS: A total of 3231 patients were included in this prospective, observational, multicentre study (Clinicaltrial.gov NCT02066623) of consecutive patients undergoing BVS implantation between November 2013 and January 2016...
August 22, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28829203/gender-related-issues-in-thrombosis-and-hemostasis
#4
Anne-Mette Hvas, Emmanuel J Favaloro
Many aspects of hemostasis, both primary and secondary, as well as fibrinolysis display sex differences. From a clinical viewpoint, certain differential phenotypic presentations clearly arise within various disorders of thrombosis and hemostasis. Areas Covered: The present mini-review summarizes selected clinical entities where sex differences are reflected in both frequency and clinical presentation of hemostasis disorders. Sex differences are discussed within the settings of cardiovascular disease, including coronary artery disease and ischemic stroke, venous thromboembolism and inherited bleeding disorders...
August 22, 2017: Expert Review of Hematology
https://www.readbyqxmd.com/read/28828893/kawasaki-disease-and-coronary-artery-aneurysms-from-childhood-to-adulthood
#5
Manjiri Joshi, Robert Tulloh
Kawasaki disease is an acute, systemic vasculitis of childhood and confers a 25% risk of developing coronary artery aneurysms. Its etiology is unknown, but the incidence is increasing rapidly with linked gene polymorphisms having been identified. A constellation of symptoms, epidemics and seasonality all implicate an unidentified infective or environmental cause. Intravenous immunoglobulin therapy, aspirin and steroids all form the mainstay of acute treatment and reduces the incidence of coronary artery aneurysms if given before 7 days...
August 22, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28828539/dysfunctional-hdl-in-diabetes-mellitus-and-its-role-in-the-pathogenesis-of-cardiovascular-disease
#6
REVIEW
Rai Ajit K Srivastava
Coronary artery disease, the leading cause of death in the developed and developing countries, is prevalent in diabetes mellitus with 68% cardiovascular disease (CVD)-related mortality. Epidemiological studies suggested inverse correlation between HDL and CVD occurrence. Therefore, low HDL concentration observed in diabetic patients compared to non-diabetic individuals was thought to be one of the primary causes of increased risks of CVD. Efforts to raise HDL level via CETP inhibitors, Torcetrapib and Dalcetrapib, turned out to be disappointing in outcome studies despite substantial increases in HDL-C, suggesting that factors beyond HDL concentration may be responsible for the increased risks of CVD...
August 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28828485/smoking-cessation-pharmacotherapy-among-smokers-hospitalized-for-coronary-heart-disease
#7
Quinn R Pack, Aruna Priya, Tara C Lagu, Penelope S Pekow, Nancy A Rigotti, Peter K Lindenauer
No abstract text is available yet for this article.
August 21, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28828324/simultaneous-genotyping-of-the-rs4762-and-rs699-polymorphisms-in-angiotensinogen-gene-and-correlation-with-iranian-cad-patients-with-novel-hexa-primer-arms-pcr
#8
Mehri Khatami, Mohammad Mehdi Heidari, Mehdi Hadadzadeh, Barbara Scheiber-Mojdehkar, Morteza Bitaraf Sani, Massoud Houshmand
BACKGROUND: A significant role of Renin-angiotensin system (RAS) genetic variants in the pathogenesis of essential hypertension and cardiovascular diseases has been proved. This study aimed to develop a new, fast and cheap method for the simultaneous detection of two missense single nucleotide polymorphisms (T207M or rs4762 and M268T orrs699) of angiotensinogen (AGT) in single-step Multiplex Hexa-Primer Amplification Refractory Mutation System - polymerase chain reaction (H-ARMS-PCR)...
June 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28828027/psychological-features-of-takotsubo-cardiomyopathy-report-of-four-cases
#9
Yaser Jenab, Seyedeh Roghaieh Hashemi, Neda Ghaffari-Marandi, Hoda Zafarghandi, Nazila Shahmansouri
Takotsubo or stress-induced cardiomyopathy is a cardiomyopathy in which the patient has a sudden onset, reversible left ventricular systolic dysfunction without any significant coronary artery disease. Four women, who were at a mean age of 64 years and suffered from chest pain exacerbated by emotional stress, were admitted as cases of acute coronary syndrome and were completely evaluated through precise history taking, physical examination, and ECG. Coronary angiography or coronary multidetector computed tomography was used to exclude significant coronary artery disease...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28828024/coronary-slow-flow-phenomenon-and-atrioventricular-block-a-case-report
#10
Mohammad Masoumi, Khadije Mohammadi
The coronary slow flow phenomenon (CSFP) is characterized by a delayed coronary blood flow in the absence of an obstructive coronary artery disease. Although the relation between the CSFP and myocardial ischemia has been reported previously, there is no knowledge about the relationship between the CSFP and the conduction system disorder. In this case report, we describe a patient with the CSFP presenting with complete heart block (CHB). The patient was a middle-aged woman with a history of diabetes, hypertension, and prior Coronary Care Unit admission presenting with dizziness, lightheadedness, and presyncope...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28828022/c1019t-polymorphism-in-the-connexin-37-gene-and-myocardial-infarction-risk-in-premature-coronary-artery-disease
#11
Mehrdad Sheikhvatan, Mohammadali Boroumand, Mehrdad Behmanesh, Seyed Hesameddin Abbasi, Gholamreza Davoodi, Shayan Ziaee, Sara Cheraghi
Background: The C1019T polymorphism of the connexin-37 (GJA4) gene is a single-nucleotide polymorphisms involved in atherosclerotic plaque rupture and atherosclerosis predisposition. We examined the association between the C1019T polymorphism of the GJA4 gene and the occurrence of myocardial infarction (MI) in patients with premature coronary artery disease (CAD). Methods: Our study recruited 1000 patients with the final diagnosis of premature CAD and classified them into 2 groups: with a history of MI (n = 461) and without it (n = 539)...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28828021/effects-of-endothelial-and-mesenchymal-stem-cells-on-improving-myocardial-function-in-a-sheep-animal-model
#12
Shahram Rabbani, Masoud Soleimani, Mohammad Sahebjam, Mohammad Imani, Seyed Mahdi Nassiri, Amir Atashi, Morteza Daliri Joupari, Ali Ghiaseddin, Mostafa Latifpour, Seyed Hossein Ahmadi Tafti
Background: Myocardial infarction is the main cause of death worldwide. Angiogenesis, a promising new therapy for the treatment of diffuse coronary artery disease, shows a poor response to conventional revascularization techniques. This study focused on improving myocardial function using endothelial cells (ECs) and mesenchymal stem cells (MSCs) in a sheep animal model. Methods: Acute myocardial infarction was induced in 18 sheep (12 treated cases and 6 controls). Autologous MSCs and ECs were injected in the infarcted area and the border zone...
April 2017: Journal of Tehran Heart Center
https://www.readbyqxmd.com/read/28827847/prevalence-of-asymptomatic-apical-periodontitis-and-its-association-with-coronary-artery-disease-in-a-brazilian-subpopulation
#13
Bruna Paloma de Oliveira, Andréa Cruz Câmara, Carlos Menezes Aguiar
OBJECTIVE: The aim of the present study was to determine the prevalence of asymptomatic apical periodontitis (AAP) and its association with coronary artery disease (CAD) in a Brazilian subpopulation, and to examine the correlation of AAP with gender, age and most frequently affected dental elements. METHODS: The data were collected from medical records of the patients (n = 1346) treated at the Specialization in Endodontics Clinic of the Federal University of Pernambuco in the period between 2003 and 2010...
June 2017: Acta Stomatologica Croatica
https://www.readbyqxmd.com/read/28827514/association-of-serum-prealbumin-with-angiographic-severity-in-patients-with-acute-coronary-syndrome
#14
Chenglong Zhang, Pei Liu, Ke Xia, Han Fang, Minna Jiang, Qiying Xie, Zaixin Yu, Tianlun Yang
BACKGROUND Serum prealbumin (PA), which is a nutritional index, has been found to be associated with severities and prognoses of various diseases. However, there are no reports about the relationship between PA and angiographic severity of coronary artery disease. MATERIAL AND METHODS This cross-sectional study included 867 patients with acute coronary syndrome (ACS) who underwent coronary angiography. Patients were divided into quartiles of PA and coronary artery stenosis was determined by angiographic Gensini score, the presence of high Gensini score (Gensini score ≥120), and triple-vessel disease...
August 21, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28827117/association-of-cnb-5i-5d-promoter-gene-polymorphism-and-serum-calcineurin-levels-in-early-onset-of-coronary-artery-disease-of-south-indian-cohort
#15
Sailaja Maddhuri, Srinivas Bandaru, Chiatanya Bhukya, Vinod Cingeetham, Amaresh Rao Malempati, M L N Deepika, Pratibha Nallari, Hema Prasad Mundluru
Calcineurin, a serine/threonine phosphatase is a calcium dependent protein which on activation triggers transcriptional up regulation of inflammatory genes associated with inflammation in the arteries and progressive formation of plaques in CAD. The present investigation is aimed to study the possible association of Calcineurin encoding gene PPP3R1 (CnB 5I/5D) polymorphism in correlation with serum levels of calcineurin in coronary artery disease (CAD). A total of 300 angiographically documented CAD patients and 300 age, gender ethnicity matched healthy controls were recruited for the study...
August 4, 2017: Gene
https://www.readbyqxmd.com/read/28826902/comparison-of-the-frequency-of-acute-kidney-injury-in-patients-with-renal-transplant-who-underwent-percutaneous-coronary-intervention-versus-coronary-artery-bypass-graft-surgery
#16
Siva Sagar Taduru, Madhuri Ramakrishnan, Reem A Mustafa, Paramdeep S Baweja
Percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG) are established modalities of coronary revascularization. Choosing between the two requires taking into consideration not only disease severity, patient characteristics, and expected outcomes but also adverse effects. One such adverse effect is acute kidney injury (AKI), especially when considering coronary revascularization in patients with renal transplant (RT). We searched the National Inpatient Sample from 2008 to 2014 using International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes for patients with RT (V42...
July 14, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28826666/paradoxical-coronary-artery-disease-in-humans-with-hyperalphalipoproteinemia-is-associated-with-distinct-differences-in-the-high-density-lipoprotein-phosphosphingolipidome
#17
William Hancock-Cerutti, Marie Lhomme, Carolane Dauteuille, Sora Lecocq, M John Chapman, Daniel J Rader, Anatol Kontush, Marina Cuchel
BACKGROUND: Plasma high-density lipoprotein cholesterol (HDL-C) levels are inversely associated with risk of coronary artery disease (CAD) in epidemiologic studies. Despite this, the directionality of this relationship and the underlying biology behind it remain to be firmly established, especially at the extremes of HDL-C levels. OBJECTIVE: We investigated differences in the HDL phosphosphingolipidome in a rare population of subjects with premature CAD despite high HDL-C levels to gain insight into the association between the HDL lipidome and CAD disease status in this unusual phenotype...
July 8, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28826564/familial-hypercholesterolemia-in-a-european-mediterranean-population-prevalence-and-clinical-data-from-2-5-million-primary-care-patients
#18
Alberto Zamora, Luís Masana, Marc Comas-Cufí, Àlex Vila, Núria Plana, Maria García-Gil, Lia Alves-Cabratosa, Jaume Marrugat, Irene Roman, Rafel Ramos
BACKGROUND: Familial hypercholesterolemia (FH), the most frequent hereditary cause of premature coronary heart disease (CHD), is underdiagnosed and insufficiently treated. OBJECTIVES: The objectives of the study were to estimate the prevalence of the FH phenotype (FH-P) and to describe its clinical characteristics in a Mediterranean population. METHODS: Data were obtained from the Catalan primary care system's clinical records database (Catalan acronym: SIDIAP)...
July 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28826313/effect-of-omega-3-polyunsaturated-fatty-acids-supplementation-on-body-composition-and-circulating-levels-of-follistatin-like-1-in-males-with-coronary-artery-disease-a-randomized-double-blind-clinical-trial
#19
Shirin Jafari Salim, Shahab Alizadeh, Mahmoud Djalali, Ebrahim Nematipour, Mohammad Hassan Javanbakht
Adipokines are mediators of body composition and are involved in obesity-related complications such as cardiovascular disease. Omega-3 supplementation has not been studied in the setting of body composition and follistatin-like 1 (FSTL1) levels in patients with coronary artery disease (CAD). This study aimed to investigate the effect of omega-3 polyunsaturated fatty acid (ω-3 PUFA) supplementation on body composition indices and serum levels of FSTL1 in CAD patients. A total of 42 male (aged 45-65 years) subjects with angiographically confirmed CAD were included in this randomized, double-blind, placebo-controlled trial study...
August 1, 2017: American Journal of Men's Health
https://www.readbyqxmd.com/read/28823011/guidelines-versus-reality-is-coronary-stent-application-in-three-vessel-disease-standard-or-the-exception
#20
Roland Linder, J Zeidler, F Verheyen, J-M Graf von der Schulenburg, A Haverich, T Schilling
The national guidelines for treatment of chronic coronary heart disease (CHD) recommend surgical coronary aortic bypass grafting (CABG) rather than percutaneous coronary intervention (PCI) for patients with a coronary three-vessel disease. The epidemiology of three-vessel CHD and data about the application of different revascularisation strategies raise suspicion of deviation from the guidelines in the treatment of those patients. Claims data containing records of almost 10 million patients of the largest German statutory health insurance fund (Techniker Krankenkasse) were utilised to measure adherence to the guidelines for treatment of groups of patients with one-, two-, and three-vessel CHD, respectively...
August 19, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
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