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https://www.readbyqxmd.com/read/28736855/-lnc-ing-wnt-in-female-reproductive-cancers-therapeutic-potential-of-long-non-coding-rnas-in-wnt-signaling
#1
REVIEW
Mei S Ong, Wanpei Cai, Yi Yuan, Hin C Leong, Tuan Z Tan, Asad Mohammad, Ming L You, Frank Arfuso, Boon C Goh, Sudha Warrier, Gautam Sethi, Nicholas S Tolwinski, Peter E Lobie, Celestial T Yap, Shing C Hooi, Ruby Y Huang, Alan P Kumar
Recent discoveries in the non-coding genome have challenged the original central dogma of molecular biology; non-coding RNAs and related processes have been found to be important in regulating gene expression. MicroRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are amongst some that have gained attention recently in human diseases, including cancer, with the involvement of many more ncRNAs waiting to be discovered. Non-coding RNAs (ncRNAs) are a group of ribonucleic acids transcribed from regions of the human genome, which do not become translated into proteins, despite having essential roles in cellular physiology...
July 24, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/28733902/clustering-and-candidate-motif-detection-in-exosomal-mirnas-by-application-of-machine-learning-algorithms
#2
Pallavi Gaur, Anoop Chaturvedi
BACKGROUND: The clustering pattern and motifs give immense information about any biological data. An application of machine learning algorithms for clustering and candidate motif detection in miRNAs derived from exosomes is depicted in this paper. Recent progress in the field of exosome research and more particularly regarding exosomal miRNAs has led much bioinformatic-based research to come into existence. The information on clustering pattern and candidate motifs in miRNAs of exosomal origin would help in analyzing existing, as well as newly discovered miRNAs within exosomes...
July 22, 2017: Interdisciplinary Sciences, Computational Life Sciences
https://www.readbyqxmd.com/read/28727756/dysregulation-of-micrornas-and-renin-angiotensin-system-in-high-salt-diet-induced-cardiac-dysfunction-in-uninephrectomized-rats
#3
Venkateswara Rao Amara, Sunil Kumar Surapaneni, Kulbhushan Tikoo
Uninephrectomy is not associated with major adverse events in cardiovascular and renal functions of live kidney donors. The effect of high salt diet on the quality of life of live kidney donors is largely unknown. Hence in this study, we aimed to determine the effect of high salt diet on the alterations of renin-angiotensin system and microRNAs leading to CV and renal dysfunction in uninephrectomized rats. In order to mimic clinical scenario, uninephrectomized male Sprague Dawley rats were fed initially with normal pellet diet for 12 weeks and then for 20 weeks with high salt (10% w/w NaCl) diet...
2017: PloS One
https://www.readbyqxmd.com/read/28727754/dysregulation-of-endothelial-colony-forming-cell-function-by-a-negative-feedback-loop-of-circulating-mir-146a-and-146b-in-cardiovascular-disease-patients
#4
Ting-Yu Chang, Wei-Chi Tsai, Tse-Shun Huang, Shu-Han Su, Chih-Young Chang, Hsiu-Yen Ma, Chun-Hsien Wu, Chih-Yung Yang, Chi-Hung Lin, Po-Hsun Huang, Cheng-Chung Cheng, Shu-Meng Cheng, Hsei-Wei Wang
Functional impairment of endothelial colony-forming cells (ECFCs), a specific cell lineage of endothelial progenitor cells (EPCs) is highly associated with the severity of coronary artery disease (CAD), the most common type of cardiovascular disease (CVD). Emerging evidence show that circulating microRNAs (miRNAs) in CAD patients' body fluid hold a great potential as biomarkers. However, our knowledge of the role of circulating miRNA in regulating the function of ECFCs and the progression of CAD is still in its infancy...
2017: PloS One
https://www.readbyqxmd.com/read/28724745/seq-identifies-circulating-mir-125a-5p-mir-125b-5p-and-mir-143-3p-as-potential-biomarkers-for-acute-ischemic-stroke
#5
Steffen Tiedt, Matthias Prestel, Rainer Malik, Nicola Schieferdecker, Marco Düring, Veronika Kautzky, Ivelina Stoycheva, Julia Böck, Bernd H Northoff, Matthias Klein, Franziska Dorn, Knut Krohn, Daniel Teupser, Arthur Liesz, Nikolaus Plesnila, Lesca M Holdt, Martin Dichgans
Rationale: Currently, there are no blood-based biomarkers with clinical utility for acute ischemic stroke (IS). microRNAs (miRNAs) show promise as disease markers due to their cell-type specific expression patterns and stability in peripheral blood. Objective: To identify circulating miRNAs associated with acute IS, determine their temporal course up to 90 days post-stroke, and explore their utility as an early diagnostic marker. Methods and Results: We used RNA sequencing to study expression changes of circulating miRNAs in a discovery sample of 20 IS patients and 20 matched healthy control subjects (HCs)...
July 19, 2017: Circulation Research
https://www.readbyqxmd.com/read/28723162/ultrasensitive-detection-of-cancer-prognostic-mirna-biomarkers-based-on-surface-plasmon-enhanced-light-scattering
#6
Chih-Tsung Yang, Mohammad Pourhassan-Moghaddam, Lin Wu, Ping Bai, Benjamin Thierry
The development of simple yet ultrasensitive biosensing approaches for the detection of cancer prognostic microRNA is an important step toward their successful clinical implementation. We demonstrate the relevance for the detection of circulating miRNA of a novel signal amplification scheme based on surface plasmon resonance enhanced light scattering (SP-LS). In addition to experimental optimization carried out using gold nanoparticle (AuNP) tags conjugated with a monoclonal antibody with high affinity for RNA*DNA hybrid duplexes, simulation modeling was conducted to obtain insights about SP-LS biosensing...
May 26, 2017: ACS Sensors
https://www.readbyqxmd.com/read/28710381/evaluation-and-diagnostic-potential-of-circulating-extracellular-vesicle-associated-micrornas-in-adrenocortical-tumors
#7
Pál Perge, Henriett Butz, Raffaele Pezzani, Irina Bancos, Zoltán Nagy, Krisztina Pálóczi, Gábor Nyírő, Ábel Decmann, Erna Pap, Michaela Luconi, Massimo Mannelli, Edit I Buzás, Miklós Tóth, Marco Boscaro, Attila Patócs, Peter Igaz
There is no available blood marker for the preoperative diagnosis of adrenocortical malignancy. The objective of this study was to investigate the expression of extracellular vesicle-associated microRNAs and their diagnostic potential in plasma samples of patients suffering from adrenocortical tumors. Extracellular vesicles were isolated either by using Total Exosome Isolation Kit or by differential centrifugation/ultracentrifugation. Preoperative plasma extracellular vesicle samples of 6 adrenocortical adenomas (ACA) and 6 histologically verified adrenocortical cancer (ACC) were first screened by Taqman Human Microarray A-cards...
July 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28709951/microrna-basic-concepts-and-implications-for-regeneration-and-repair-of-neurodegenerative-diseases
#8
REVIEW
Cláudia Saraiva, Marta Esteves, Liliana Bernardino
MicroRNAs (miRNA) are small non-coding molecules that revolutionized our knowledge about the regulation of gene expression. Capable to target a large number of mRNA, miRNA are thought to regulate around 30% of the entire human genome. Therefore, these molecules are able to regulate several biological processes, including neuronal survival, differentiation and regeneration. Additionally, miRNA might act as valuable clinical agents in brain pathological conditions: their specific expression patterns in the brain parenchyma and/or in circulating fluids have been highlighted as potential biomarkers while the modulation of their activity may have therapeutic value for several neurodegenerative diseases...
July 11, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28706977/acute-rejection-after-kidney-transplantation-associates-with-circulating-micrornas-and-vascular-injury
#9
Roel Bijkerk, Barend W Florijn, Meriem Khairoun, Jacques M G J Duijs, Gurbey Ocak, Aiko P J de Vries, Alexander F Schaapherder, Marko J K Mallat, Johan W de Fijter, Ton J Rabelink, Anton Jan van Zonneveld, Marlies E J Reinders
BACKGROUND: Acute rejection (AR) of kidney transplants is associated with the loss of endothelial integrity, microvascular rarefaction and, ultimately, graft dysfunction. Circulating angiogenic microRNAs (miRNAs) may serve as markers for microvascular injury. Here, we investigated the short- and long-term effects of AR after kidney transplantation on systemic vascular injury and the associated circulating miRNA profile. METHODS: Systemic vascular injury was determined by measuring capillary tortuosity and density within the oral mucosa as well as by assessing circulating levels of angiopoietin-2/angiopoietin-1 ratio, vascular endothelial growth factor and soluble thrombomodulin...
July 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28703277/mirnas-and-ovarian-cancer-an-overview
#10
REVIEW
Bornali Deb, Arif Uddin, Supriyo Chakraborty
Ovarian cancer (OC) is the sixth most common cancer in women globally. However, even with the advances in detection andtherapeutics it still represents the most dangerous gynecologic malignancy in women of the industrialized countries. The discovery of micro- RNAs (miRNA), a small noncoding RNA molecule targeting multiple mRNAs and regulation of gene expression by triggering translation repression and/or RNA degradation, has revealed the existence of a new array for regulation of genes involved in cancer. This review summarizes the current knowledge regarding the role of miRNAs expression in OC...
July 13, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28701783/circulating-mir-323-3p-is-a-biomarker-for-cardiomyopathy-and-an-indicator-of-phenotypic-variability-in-friedreich-s-ataxia-patients
#11
M Seco-Cervera, D González-Rodríguez, J S Ibáñez-Cabellos, L Peiró-Chova, P González-Cabo, E García-López, J J Vílchez, I Sanz-Gallego, F V Pallardó, J L García-Giménez
MicroRNAs (miRNAs) are noncoding RNAs that contribute to gene expression modulation by regulating important cellular pathways. In this study, we used small RNA sequencing to identify a series of circulating miRNAs in blood samples taken from Friedreich's ataxia patients. We were thus able to develop a miRNA biomarker signature to differentiate Friedreich's ataxia (FRDA) patients from healthy people. Most research on FDRA has focused on understanding the role of frataxin in the mitochondria, and a whole molecular view of pathological pathways underlying FRDA therefore remains to be elucidated...
July 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28701355/mir-4632-mediates-pdgfbb-induced-proliferation-and-anti-apoptosis-of-human-pulmonary-artery-smooth-muscle-cells-via-targeting-cjun
#12
Zhengjiang Qian, Yanjiao Li, Jidong Chen, Xiang Li, Deming Gou
MicroRNAs (miRNAs) can regulate proliferative status of pulmonary artery smooth muscle cells (PASMCs), which is a core factor modulating pulmonary vascular remodeling diseases, such as atherosclerosis and pulmonary arterial hypertension (PAH). Our previous work has shown that miR-4632, a rarely reported miRNA, is significantly downregulated in Platelet-Derived Growth Factor (PDGF)BB-stimulated human pulmonary artery smooth muscle cells (HPASMCs), yet its cell function and the underlying molecular mechanisms remain to be elucidated...
July 12, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28699915/circulating-mirnas-as-novel-diagnostic-biomarkers-in-hepatocellular-carcinoma-detection-a-meta-analysis-based-on-24-articles
#13
Yan Ding, Jia-Iai Yan, An-Ning Fang, Wei-Feng Zhou, Ling Huang
The diagnostic value and suitability of circulating miRNAs for the detection of hepatocellular carcinoma have been inconsistent in the literature. A meta-analysis to systematically evaluate the diagnostic value of circulating miRNAs. Eligible studies were selected and the heterogeneity was assessed by subgroup analysis, meta-regression, and publication bias. After strictly and comprehensive screening, the source methods, internal reference and the cut-off values of the included miRNAs were first listed. Circulating miRNAs demonstrated a relatively good diagnostic value in hepatocellular carcinoma, In the subgroup analysis, diagnosis odds ratio showed a higher accuracy with multiple miRNAs than with a single miRNA as well as with serum types than plasma types...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28694210/circulating-microrna-expression-as-predictor-of-preeclampsia-and-its-severity
#14
Deeba S Jairajpuri, Zainab H Malalla, Naeema Mahmood, Wassim Y Almawi
Preeclampsia (PE) is a pregnancy syndrome characterized by hypertension and proteinuria, and a leading cause of maternal and fetal morbidity and mortality, with poorly defined pathophysiological mechanisms remain. Circulating microRNAs (miRNAs) are small, noncoding RNA molecules, which negatively regulate gene expression, and considered as promising biomarkers for PE. The objective of the study was to evaluate circulating miRNA signatures in women with PE compared to healthy women, and in women sub-grouped per PE severity...
July 7, 2017: Gene
https://www.readbyqxmd.com/read/28694015/predicting-treatment-resistance-and-relapse-through-circulating-dna
#15
Emma Beddowes, Stephen J Sammut, Meiling Gao, Carlos Caldas
The use of circulating DNA(ctDNA) to provide a non-invasive, personalised genomic snapshot of a patients' tumour has huge potential. Over the past five years this area of research has gained huge momentum. A number of studies in metastatic breast cancer have shown the potential of ctDNA to predict prognosis and treatment response using ctDNA. Further developments have included deeper sequencing using whole exome and shallow whole genome approaches which has the potential to identify new mutations and chromosomal copy number changes which appear upon resistance to treatment...
July 7, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28693530/analysis-of-circulating-micrornas-in-patients-with-repaired-tetralogy-of-fallot-with-and-without-heart-failure
#16
Masood Abu-Halima, Eckart Meese, Andreas Keller, Hashim Abdul-Khaliq, Tanja Rädle-Hurst
BACKGROUND: MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) patients late after surgical repair. In this study, we aimed to identify the specific patterns of circulating miRNAs in blood of patients with repaired, non-syndromic TOF and to assess whether these specific miRNAs may be useful to differentiate patients with and without heart failure...
July 10, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28690499/reduced-circulating-levels-of-mir-433-and-mir-133b-are-potential-biomarkers-for-parkinson-s-disease
#17
Xiong Zhang, Rui Yang, Bei-Lei Hu, Pengcheng Lu, Li-Li Zhou, Zhi-Yong He, Hong-Mei Wu, Jian-Hong Zhu
Aberrant expression of microRNA (miRNA) in tissues may lead to altered level in circulation. Considerable evidence has suggested that miRNA deregulation is involved in the pathogenesis of Parkinson's disease (PD). In this study, we screened a set of PD-associated miRNAs and aimed to identify differentially expressed miRNAs in plasma of PD patients and to evaluate their potentiality to serve as PD biomarkers. A total of 95 subjects consisting of 46 sporadic PD cases and 49 controls were recruited. Plasma levels of six miRNAs including miR-433, miR-133b, miR-34b, miR-34c, miR-153, and miR-7 were evaluated using reverse transcribed quantitative PCR, among which we found that miR-34c and miR-7 were below detection limit under our condition...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28689512/circulating-mir-23b-3p-mir-145-5p-and-mir-200b-3p-are-potential-biomarkers-to-monitor-acute-pain-associated-with-laminitis-in-horses
#18
C Lecchi, E Dalla Costa, D Lebelt, V Ferrante, E Canali, F Ceciliani, D Stucke, M Minero
Circulating microRNAs (miRNAs) are emerging as promising biomarkers for several disorders and related pain. In equine practice, acute laminitis is a common disease characterised by intense pain that severely compromises horse welfare. Recently, the Horse Grimace Scale (HGS), a facial expression-based pain coding system, was shown to be a valid welfare indicator to identify pain linked to acute laminitis. The present study aimed to: determine whether miRNAs can be used as biomarkers for acute pain in horses (Equus caballus) affected by laminitis; integrate miRNAs to their target genes and to categorise target genes for biological processes; gather additional evidence on concurrent validity of HGS by investigating how it correlates to miRNAs...
July 10, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28681241/platelet-rna-signatures-for-the-detection-of-cancer
#19
Nik Sol, Thomas Wurdinger
Platelets are equipped with RNA processing machineries, such as pre-mRNA splicing, pre-miRNA processing, and mRNA translation. Since platelets are devoid of a nucleus, most RNA transcripts in platelets are derived from megakaryocytes during thrombocytogenesis. However, platelets can also ingest RNA molecules during circulation and/or interaction with other cell types. Since platelets were first described by Bizzozero in 1881, their well-established role in hemostasis and thrombosis has been intensively studied...
July 5, 2017: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/28678586/extracellular-vesicle-biology-in-the-pathogenesis-of-lung-disease
#20
Serge P Nana-Sinkam, Mario Acunzo, Carlo M Croce, Kai Wang
As our understanding of diseases of the lung continues to evolve, we recognize that the mechanisms that drive cell/environment communication leading to disease development and progression are complex. In 2008, investigators first identified intact cell free microRNAs in circulation with some localized within lipid-encapsulated microvesicles termed extracellular vesicles (EVs). Prior to and following this discovery, investigators have determined that EVs may drive biological processes fundamental to human disease and homeostasis...
July 5, 2017: American Journal of Respiratory and Critical Care Medicine
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