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https://www.readbyqxmd.com/read/27914211/micrornas-in-cardiovascular-disease-clinical-application
#1
Christian Schulte, Mahir Karakas, Tanja Zeller
microRNAs (miRNAs) are well-known, powerful regulators of gene expression, and their potential to serve as circulating biomarkers is widely accepted. In cardiovascular disease (CVD), numerous studies have suggested miRNAs as strong circulating biomarkers with high diagnostic as well as prognostic power. In coronary artery disease (CAD) and heart failure (HF), miRNAs have been suggested as reliable biomarkers matching up to established protein-based such as cardiac troponins (cT) or natriuretic peptides. Also, in other CVD entities, miRNAs were identified as surprisingly specific biomarkers - with great potential for clinical applicability, especially in those entities that lack specific protein-based biomarkers such as atrial fibrillation (AF) and acute pulmonary embolism (APE)...
December 3, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27907140/detection-of-acute-radiation-sickness-a-feasibility-study-in-non-human-primates-circulating-mirnas-for-triage-in-radiological-events
#2
Naresh Menon, Claude J Rogers, Agnes I Lukaszewicz, James Axtelle, Marshleen Yadav, Feifei Song, Arnab Chakravarti, Naduparambil K Jacob
Development of biomarkers capable of estimating absorbed dose is critical for effective triage of affected individuals after radiological events. Levels of cell-free circulating miRNAs in plasma were compared for dose-response analysis in non-human primates (NHP) exposed to lethal (6.5 Gy) and sub-lethal (1 and 3 Gy) doses over a 7 day period. The doses and test time points were selected to mimic triage needs in the event of a mass casualty radiological event. Changes in miRNA abundance in irradiated animals were compared to a non-irradiated cohort and a cohort experiencing acute inflammation response from exposure to lipopolysaccharide (LPS)...
2016: PloS One
https://www.readbyqxmd.com/read/27904930/micrornas-in-bone-diseases
#3
REVIEW
L Gennari, S Bianciardi, D Merlotti
MicroRNAs are small, noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression, with an essential role in vertebrate development and different biological processes. This review highlights the recent advances in the function of miRNAs and their roles in bone remodeling and bone diseases. MicroRNAs (miRNAs) are a class of small (∼22 nt), noncoding single-stranded RNAs that have emerged as important posttranscriptional regulators of gene expression. They are essential for vertebrate development and play critical roles in different biological processes related to cell differentiation, activity, metabolism, and apoptosis...
November 30, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27904783/circulating-mirna-profile-in-esophageal-adenocarcinoma
#4
Keqiang Zhang, Xiwei Wu, Jinhui Wang, Joshua Lopez, Weiying Zhou, Lu Yang, Shizhen Emily Wang, Dan J Raz, Jae Y Kim
Esophageal cancer is one of the deadliest cancers worldwide. It typically has a poor overall prognosis because of diagnosis in advanced stages. Sensitive biomarkers for the early detection of esophageal cancer are urgently needed to reduce the high mortality of this disease. Circulating microRNAs (miRNAs) are emerging as a novel non-invasive biomarker for cancer diagnosis due to its high stability and specificity. In this study, we profiled circulating miRNAs in serum of patients with esophageal adenocarcinoma (EAC) using the Solexa sequencing analysis...
2016: American Journal of Cancer Research
https://www.readbyqxmd.com/read/27901112/depletion-of-trna-halves-enables-effective-small-rna-sequencing-of-low-input-murine-serum-samples
#5
Alan Van Goethem, Nurten Yigit, Celine Everaert, Myrthala Moreno-Smith, Liselot M Mus, Eveline Barbieri, Frank Speleman, Pieter Mestdagh, Jason Shohet, Tom Van Maerken, Jo Vandesompele
The ongoing ascent of sequencing technologies has enabled researchers to gain unprecedented insights into the RNA content of biological samples. MiRNAs, a class of small non-coding RNAs, play a pivotal role in regulating gene expression. The discovery that miRNAs are stably present in circulation has spiked interest in their potential use as minimally-invasive biomarkers. However, sequencing of blood-derived samples (serum, plasma) is challenging due to the often low RNA concentration, poor RNA quality and the presence of highly abundant RNAs that dominate sequencing libraries...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27899750/circulating-micrornas-as-novel-biomarkers-of-stenosis-progression-in-asymptomatic-carotid-stenosis
#6
Sandra Dolz, David Górriz, José Ignacio Tembl, Dolors Sánchez, Gerardo Fortea, Vera Parkhutik, Aida Lago
BACKGROUND AND PURPOSE: Progression of asymptomatic carotid artery stenosis (ACAS) in patients with >50% luminal narrowing is considered a potential risk factor for ischemic stroke; however, subclinical molecular biomarkers of ACAS progression are lacking. Recent studies suggest a regulatory function for several microRNAs (miRNAs) on the evolution of carotid plaque, but its role in ACAS progression is mostly unknown. The aim of our study was to investigate a wide miRNA panel in peripheral blood exosomes from patients with ACAS to associate circulating miRNA expression profiles with stenosis progression...
November 29, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27895662/muscle-enriched-micrornas-isolated-from-whole-blood-are-regulated-by-exercise-and-are-potential-biomarkers-of-cardiorespiratory-fitness
#7
Joshua Denham, Priscilla R Prestes
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally. Evidence indicating miRNAs influence exercise-induced health and performance adaptations is mounting. Circulating miRNAs are responsible for intercellular communication and could serve as biomarkers for disease and exercise-related traits. Such biomarkers would contribute to exercise screening, monitoring, and the development of personalized exercise prescription. Accordingly, we investigated the impact of long-term strenuous aerobic exercise training and a single bout of maximal aerobic exercise on five muscle-enriched miRNAs implicated in exercise adaptations (miR-1, miR-133a, miR-181a, miR-486, and miR-494)...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27890424/recent-scenario-of-microrna-as-diagnostic-and-prognostic-biomarkers-of-prostate-cancer
#8
REVIEW
Kamla Kant Shukla, Sanjeev Misra, Puneet Pareek, Vivek Mishra, Barkha Singhal, Praveen Sharma
Prostate cancer (CaP) is a leading cause of cancer death and displays a broad range of clinical behavior from relatively indolent to aggressive metastatic disease. Due to the alteration and incomplete characterization of the CaP genomic markers, the quest for novel cellular metabolic regulatory molecules like micro RNA (miRNA) as a biomarker could be considered for the prognosis and treatment of CaP in future. In this article, we review the existing literature pertaining to CaP. Study provides a comprehensive miRNA profile expressed in CaP...
November 24, 2016: Urologic Oncology
https://www.readbyqxmd.com/read/27885839/the-association-of-plasma-mir-155-and-vcam-1-levels-with-coronary-collateral-circulation
#9
Junnan Wang, Youyou Yan, Dandan Song, Lulu Liu, Bin Liu
AIM: Inflammation plays an important role in development of coronary collateral circulation (CCC). The aim of this study is to determine whether the inflammation-related miRNA miR-155 and the inflammation marker VCAM-1 could be a biomarker for CCC. PATIENTS & METHODS: We measured levels of plasma VCAM-1 and miR-155 in patients with CCC according to Rentrop grade by ELISA or real-time polymerase chain reaction, respectively (n = 112). RESULTS: Plasma miR-155 was negatively correlated with VCAM-1 in the poor CCC group and with Rentrop grade in all patients with CCC...
November 25, 2016: Biomarkers in Medicine
https://www.readbyqxmd.com/read/27882350/plasma-vesicle-mirnas-for-therapy-response-monitoring-in-hodgkin-lymphoma-patients
#10
Monique A J van Eijndhoven, Josée M Zijlstra, Nils J Groenewegen, Esther E E Drees, Stuart van Niele, S Rubina Baglio, Danijela Koppers-Lalic, Hans van der Voorn, Sten F W M Libregts, Marca H M Wauben, Renee X de Menezes, Jan R T van Weering, Rienk Nieuwland, Lydia Visser, Anke van den Berg, Daphne de Jong, D Michiel Pegtel
BACKGROUND. Cell-free circulating nucleic acids, including 22-nt microRNAs (miRNAs), represent noninvasive biomarkers for treatment response monitoring of cancer patients. While the majority of plasma miRNA is bound to proteins, a smaller, less well-characterized pool is associated with extracellular vesicles (EVs). Here, we addressed whether EV-associated miRNAs reflect metabolic disease in classical Hodgkin lymphoma (cHL) patients. METHODS. With standardized size-exclusion chromatography (SEC), we isolated EV-associated extracellular RNA (exRNA) fractions and protein-bound miRNA from plasma of cHL patients and healthy subjects...
November 17, 2016: JCI Insight
https://www.readbyqxmd.com/read/27882321/micrornas-in-coronary-heart-disease-ready-to-enter-the-clinical-arena
#11
REVIEW
Elena Cavarretta, Giacomo Frati
Coronary artery disease (CAD) and its complication remain the leading cause of mortality in industrialized countries despite great advances in terms of diagnosis, prognosis, and treatment options. MicroRNAs (miRNAs), small noncoding RNAs, act as posttranscriptional gene expression modulators and have been implicated as key regulators in several physiological and pathological processes linked to CAD. Circulating miRNAs have been evaluated as promising novel biomarkers of CAD, acute coronary syndromes, and acute myocardial infarction, with prognostic implications...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27870469/a-panel-of-circulating-mirnas-as-diagnostic-biomarkers-for-screening-multiple-myeloma-a-systematic-review-and-meta-analysis
#12
REVIEW
L Zhang, D Cao, L Tang, C Sun, Y Hu
Circulating microRNAs (miRNAs) have been proved to be effective diagnostic markers for multiple myeloma (MM). The meta-analysis was aimed to evaluate the diagnostic value of related miRNAs. Multiple databases (PubMed, Web of Science, EMBASE, Cochrane Library, CBM, and CNKI) were systematically searched for available studies up to March 2016. All data were analyzed with the help of software revman 5.3 and metadisc 1.4. The eligible articles' quality was estimated by QUADAS-2, and pooled parameters were acquired with the bivariate random-effects meta-analysis model...
December 2016: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27869909/altered-levels-of-circulating-cytokines-and-micrornas-in-lean-and-obese-individuals-with-prediabetes-and-type-2-diabetes
#13
Yury O Nunez Lopez, Gabriella Garufi, Attila A Seyhan
Today obesity and type 2 diabetes (T2D) have both reached epidemic proportions. However, our current understanding of the primary mechanisms leading to these diseases is still limited due to the complex multifactorial nature of the underlying phenomena. We hypothesize that the levels of specific cytokines and miRNAs vary across the diabetes spectrum and unique signatures associated with them may serve as early biomarkers of the disease and provide insights into respective pathogenetic mechanisms. In this study, we measured the circulating levels of cytokines and microRNAs (miRNAs) in lean and obese humans with prediabetes (n = 21), T2D (n = 17), and healthy controls (n = 20) (ORIGINS trial, NCT02226640)...
November 21, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27868028/circulating-extracellular-vesicles-containing-mirnas-may-have-utility-as-early-biomarkers-for-cardiac-injury
#14
COMMENT
Bethany Doran, Deepak Voora
No abstract text is available yet for this article.
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27866223/circulating-microrna-levels-predict-residual-beta-cell-function-and-glycaemic-control-in-children-with-type-1-diabetes-mellitus
#15
Nasim Samandari, Aashiq H Mirza, Lotte B Nielsen, Simranjeet Kaur, Philip Hougaard, Siri Fredheim, Henrik B Mortensen, Flemming Pociot
AIMS/HYPOTHESIS: We aimed to identify circulating microRNA (miRNA) that predicts clinical progression in a cohort of 123 children with new-onset type 1 diabetes mellitus. METHODS: Plasma samples were prospectively obtained at 1, 3, 6, 12 and 60 months after diagnosis from a subset of 40 children from the Danish Remission Phase Cohort, and profiled for miRNAs. At the same time points, meal-stimulated C-peptide and HbA1c levels were measured and insulin-dose adjusted HbA1c (IDAA1c) calculated...
November 19, 2016: Diabetologia
https://www.readbyqxmd.com/read/27866054/comparison-of-mirna-signature-versus-conventional-biomarkers-before-and-after-off-pump-coronary-artery-bypass-graft
#16
Fatemeh Pourrajab, Fereshteh Torkian Velashani, Masoud Khanaghaei, Seyedhossein Hekmatimoghaddam, Mahdi Rahaie, Mohamad Reza Zare-Khormizi
Circulating levels of microRNAs (miRNAs) and their expression patterns are supposed to serve as signatures for diagnosis or prognosis of cardiovascular events. The present study aimed at determining if there is any correlation between the release pattern of 2 miRNAs and the plasma levels of conventional biomarkers cardiac troponin I (cTnI), creatine kinase (CK) and uric acid (UA) in patients undergoing their first off-pump coronary artery bypass graft (OCABG). Seventy OCABG patients (69% men, aged 59.2±8.2years) were enrolled...
November 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27857721/circulating-plasma-micrornas-as-diagnostic-markers-for-nsclc
#17
REVIEW
Jinpao Hou, Fei Meng, Lawrence W C Chan, William C S Cho, S C Cesar Wong
Lung cancer is the most common cause of cancer deaths all over the world, in which non-small cell lung cancer (NSCLC) accounts for ~85% of cases. It is well known that microRNAs (miRNAs) play a critical role in various cellular processes, mediating post-transcriptional silencing either by mRNA degradation through binding the 3' UTR of target mRNA or by translational inhibition of the protein. In the past decade, miRNAs have also been increasingly identified in biological fluids such as human serum or plasma known as circulating or cell-free miRNAs, and may function as non-invasive diagnostic markers for various cancer types including NSCLC...
2016: Frontiers in Genetics
https://www.readbyqxmd.com/read/27855513/recent-developments-in-circulating-biomarkers-in-parkinson-s-disease-the-potential-use-of-mirnas-in-a-clinical-setting
#18
Marcia Cristina Teixeira Dos Santos, Rosie Bell, Andre Nogueira da Costa
Parkinson's disease (PD) is the second most common neurodegenerative disorder, affecting 5% of the elderly population. PD diagnosis is still based on the identification of neuromotor symptoms although nonmotor manifestations emerge years prior to diagnosis. The discovery of biomarkers at the earliest stages of PD is of extreme interest. miRNAs have been considered potential biomarkers for neurodegenerative diseases, but only a limited number have been found to be PD related. This review focuses on the current findings in the field of circulating miRNAs in PD and the challenges surrounding clinical utility and validation...
December 2016: Bioanalysis
https://www.readbyqxmd.com/read/27855199/the-values-of-coronary-circulating-mirnas-in-patients-with-atrial-fibrillation
#19
Guiyu Xu, Yuxia Cui, Zhenghua Jia, Yunan Yue, Shuixiang Yang
The mechanism of miRNA regulation in atrial fibrillation (AF) occurrence and development is still unclear, especially, the regulating values of coronary circulating miRNAs has not been reported. Based on our AF radiofrequency ablation clinical practice and previous miRNA study, we proposed a hypothesis that the coronary circulating miRNA might much better reflect the regulating state and metabolic level of myocardial miRNA in AF patient. To investigate the regulating values of coronary circulation miRNA, 90 AF patients were selected and compared with 90 healthy subjects, the changes of coronary circulating miRNA differential expression profile in the whole genome were observed in this study...
2016: PloS One
https://www.readbyqxmd.com/read/27846323/plasma-microrna-16-is-a-biomarker-for-diagnosis-stratification-and-prognosis-of-hyperacute-cerebral-infarction
#20
Chunou Tian, Zifu Li, Zhigang Yang, Qinghai Huang, Jianmin Liu, Bo Hong
Indices for the diagnosis of hyperacute cerebral infarction (HACI) and the prediction of prognosis are essential for timely and appropriate management. MicroRNAs (miRNAs) that regulate gene expression following stroke have potential use as prognostic markers of HACI. Here, we explored whether concentrations of circulating miRNAs correlate with clinical outcomes and thus form a system of stroke stratification. Plasma samples from patients with HACI (n = 7) and age-matched healthy volunteers (HVT, n = 4) were screened by microarray to find differentially expressed miRNAs, some of which were further verified by quantitative reverse transcription polymerase chain reaction (qRT-PCR) (HACI:HVT = 33:23)...
2016: PloS One
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