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Clopidogrel myeloproliferative

Christoph Robier, Mariana Stettin, Manfred Neubauer
In the present study, we used multiple electrode aggregometry (MEA) to investigate the response to aspirin and clopidogrel treatment, and its potential changes over a long-time disease course in patients with myeloproliferative neoplasms (MPNs). arachidonic acid (ASPI), ADP, and thrombin receptor activating peptide (TRAP) tests were performed at two timepoints between 32-50 months in 21 patients with MPN and 1-46 months in 29 controls. We further checked the medical records of the participants to identify a potential correlation of changes in the treatment response with clinical events...
December 2013: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Anand Singla, Dinesh Jagasia, Mukesh Garg, Philip A Lowry, Dwight Stapleton
Essential thrombocythemia (ET) is a myeloproliferative disorder characterized by hemorrhagic and thrombotic complications. We describe a rare case of ST-segment elevation myocardial infarction (STEMI) in a patient with previously undiagnosed ET, confirmed by gene mutation. A 68-year-old man presented with severe acute chest pain and was diagnosed with STEMI. Primary coronary angiography showed severe stenosis with thrombus in the proximal left anterior descending coronary artery. Percutaneous aspiration thrombectomy was performed with no residual stenosis...
2012: Platelets
Federico Cacciapuoti
Inherited and acquired tendency to the formation of clots represents an important cause of morbidity and mortality for ischemic events in young people (aged between 40 and 50 years) that is more and more frequently identified. The haemostasis' disorders may happen on the venous or arterial side. Arterial thrombus is a 'white' thrombus, also called temporary thrombus. It consists of aggregate platelets only. On the contrary, venous thrombus is 'red' or permanent thrombus composed of platelets, red cells and fibrin...
April 2011: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Katrine M Müllertz, Hanne Vestergaard, Henrik Steen Hansen
Essential thrombocythaemia (ET) is an acquired myeloproliferative disorder that causes thrombosis and haemorrhage. The association of myocardial infarction with ET is rare. We here describe a 22 year-old male patient with ET who presented with acute myocardial infarction. Coronary angiography showed multi-vessel thrombosis. Percutaneous coronary angioplasty was successfully performed. The patient was treated with abciximab after percutaneous coronary intervention. Bone marrow biopsy confirmed ET; treatment was started with interferon-alpha along with aspirin and clopidogrel without haemorrhagic complications...
February 21, 2011: Ugeskrift for Laeger
Christoph Robier, Manfred Neubauer, Heinz Sternad, Franz Quehenberger, Franz Rainer, Peter Neumeister
BACKGROUND: The aim of this study was to describe platelet aggregation characteristics by multiple electrode aggregometry (MEA) and to evaluate MEA for its potential to detect platelet dysfunction and response to anti-aggregatory drugs in patients with myeloproliferative disorders (MPD). METHODS: We compared the platelet response to arachidonic acid (ASPI test), adenosine diphosphate (ADP test) and thrombin receptor activating peptide (TRAP test) in hirudin-anticoagulated blood of 55 patients with polycythaemia vera and essential thrombocythaemia and 75 controls...
September 2010: Thrombosis Research
Meltem Tekin, Serkan Gökaslan, Erdem Diker, Sinan Aydoğdu
Little is known about the management of coronary thrombosis in myeloproliferative disease. The occurrence of myocardial infarction in myeloproliferative disease is mostly attributed to coronary thrombosis due to hyperviscosity and thrombocytosis. We presented three cases of acute myocardial infarction associated with polycythemia vera in one patient (male, age 33 years) and essential thrombocytosis in two patients (male, ages 36 and 46 years). None of the patients had diabetes mellitus, hypertension, hyperlipidemia, or a positive family history...
January 2008: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Mehmet Kayrak, Kadir Acar, Mehmet Yazici, Coskun Kaya, S Selim Ayhan, Hasan Gok
Essential thrombocythemia is a clonal myeloproliferative disorder that causes thrombocytosis. Essential thrombocythemia is characterized by increased incidence of thrombosis with arterial event more than venous events and hemorrhagic complications. Acetylsalicylic acid enhances both minor and major bleedings. The authors describe pericardial hemorrhage, which is related to the use of low-dose acetylsalicylic acid in a patient with essential thrombocythemia. The patient was successfully managed with clopidogrel therapy during the 16 months follow-up without recurrent thrombotic or hemorrhagic events...
July 2009: Clinical and Applied Thrombosis/hemostasis
C Doesch, A E May, G Toncar-Pflumm, N Anders, T Geisler, S Kröber, R Kandolf, M Gawaz
A 48-year-old man presented with acute chest pain and a greatly increased platelet count. Emergency coronary angiographic revealed thrombotic occlusion of the right coronary artery. Coronary angioplasty and stenting were successfully combined with intracoronary abciximab administration. Due to inadequate postinterventional platelet inhibition an intensified dual antiplatelet therapy with acetylsalicylic acid (ASS) and clopidogrel was applied to prevent stent thrombosis. Due to the thrombo-embolic complication and a platelet count over 1 million/microl a cytoreductive treatment with hydroxyurea was initiated...
November 2007: Der Internist
Bilgehan Savaş Oz, Fatih Asgun, Hakki Tankut Akay, Erkan Kaya, Erkan Kuralay, Harun Tatar
Polycythemia vera is a myeloproliferative disorder associated with the thromboembolic events. Normalization of the hematocrit and elevated platelet counts is obligatory to reduce the thrombotic risk of patients with PV. Therapeutic strategies include phlebotomy, myelosuppressive agents, and, more recently, interferon-alpha. In addition, appropriate antiplatelet therapy should be administered to prevent life-threatening complications and reducing the viscosity of the blood. Although aspirin is widely preferred in such patients, this monodrug therapy or combined with clopidogrel as an alternative approach might not be enough, especially after coronary artery surgery...
September 2007: Journal of Cardiac Surgery
A Manoharan, R Gemmell, T Hartwell
Twenty-seven patients with chronic myeloproliferative disorders and in vitro evidence of platelet hyperactivity on whole blood platelet lumi-aggregometry were commenced on anti-platelet therapy comprising aspirin, clopidogrel, and/or odorless garlic and the studies were repeated to assess the efficacy of the therapeutic agent(s). Only 8 patients showed clear evidence of anti-platelet effect while receiving the standard low-dose (100 mg/day) aspirin therapy. Thirteen patients required a higher dosage of aspirin and/or an additional anti-platelet agent to achieve therapeutic adequacy...
September 2006: American Journal of Hematology
E B Friedrich, M Kindermann, A Link, M Böhm
Polycythemia vera is a myeloproliferative disorder predisposing to thromboembolic and bleeding complications. We report the case of a patient with polyglobuly, leukocytosis, and thrombocytosis, who suffered from acute ST-segment elevation myocardial infarction due to thrombotic high-grade pre-stent stenosis two months after percutaneous coronary intervention for complex coronary one vessel disease. Following re-PTCA and stent implantation in conjunction with periinterventional GP IIb/IIIa antagonist treatment, the patient was initially symptom free for about two hours before rapidly developing signs of a hemorrhagic shock...
March 2005: Zeitschrift Für Kardiologie
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