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https://www.readbyqxmd.com/read/29339436/rewired-notch-p53-by-numb-ing-mdm2
#1
Hyungsoo Kim, Ze'ev A Ronai
Although numerous pathways are known to control the tumor suppressor protein p53, coordinated regulation of the p53-Notch axis by Numb may have an even more remarkable impact. In this issue, Colaluca at al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201709092) reveal an unexpected role of a newly characterized Numb splice variant in the regulation of p53, which may have significant implications for therapeutic intervention in breast cancer.
January 16, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29295957/the-depalmitoylase-apt1-directs-the-asymmetric-partitioning-of-notch-and-wnt-signaling-during-cell-division
#2
Ewa Stypulkowski, Irfan A Asangani, Eric S Witze
Asymmetric cell division results in two distinctly fated daughter cells. A molecular hallmark of asymmetric division is the unequal partitioning of cell fate determinants. We have previously established that growth factor signaling promotes protein depalmitoylation to foster polarized protein localization, which, in turn, drives migration and metastasis. We report protein palmitoylation as a key mechanism for the asymmetric partitioning of the cell fate determinants Numb and β-catenin through the activity of the depalmitoylating enzyme APT1...
January 2, 2018: Science Signaling
https://www.readbyqxmd.com/read/29290973/human-oncoprotein-musashi-2-n-terminal-rna-recognition-motif-backbone-assignment-and-identification-of-rna-binding-pocket
#3
Lan Lan, Minli Xing, Justin T Douglas, Philip Gao, Robert P Hanzlik, Liang Xu
RNA-binding protein Musashi-2 (MSI2) is a key regulator in stem cells, it is over-expressed in a variety of cancers and its higher expression is associated with poor prognosis. Like Musashi-1, it contains two N-terminal RRMs (RNA-recognition Motifs, also called RBDs (RNA-binding Domains)), RRM1 and RRM2, which mediate the binding to their target mRNAs. Previous studies have obtained the three-dimensional structures of the RBDs of Musashi-1 and the RBD1:RNA complex. Here we show the binding of MSI2-RRM1 to a 15nt Numb RNA in Fluorescence Polarization assay and time resolved Fluorescence Resonance Energy Transfer assay...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29280313/efficacy-and-safety-of-oxycodone-naloxone-as-add-on-therapy-to-gabapentin-or-pregabalin-for-the-management-of-chemotherapy-induced-peripheral-neuropathy-in-korea
#4
Bong-Seog Kim, Jong-Youl Jin, Jung Hye Kwon, In Sook Woo, Yoon Ho Ko, Suk-Young Park, Hye-Jeong Park, Jin Hyung Kang
AIMS: To investigate the efficacy and safety of oxycodone/naloxone in patients with chemotherapy-induced peripheral neuropathy (CIPN) inadequately controlled with pregabalin or gabapentin. METHODS: This 4-week, multicenter, interventional, single-arm phase IV study included 72 Korean patients with CIPN inadequately controlled with pregabalin or gabapentin (Numeric Rating Scale 0-10; NRS ≥4 at baseline). In addition to pregabalin or gabapentin at existing doses, patients received 20/10 mg/day oxycodone/naloxone (up-titrated to 80/40 mg/day as needed)...
December 27, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29279701/a-rare-case-of-docetaxel-induced-hydrocephalus-presenting-with-gait-disturbances-mimicking-and-coexisting-with-taxane-associated-polyneuropathy-the-relevance-of-differential-diagnosis-clinical-assessment-and-response-to-ventriculoperitoneal-shunt
#5
Lucas Ezequiel Serrano Sponton, Elke Januschek
Docetaxel constitutes a widely used chemotherapeutic agent as a first-line treatment for several neoplastic diseases. One of the most common side effects induced by this drug is polyneuropathy, which among other symptoms can cause gait disbalance. However, in exceptional cases gait disturbances could be related to docetaxel-induced hydrocephalus, a rare event that up to the present has been overseen throughout the medical literature and should be meticulously differentiated from polyneuropathy, since its clinical features, treatment, and prognosis differ drastically...
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29276224/feasibility-trial-of-oral-uft-after-platinum-based-adjuvant-chemotherapy-in-patients-with-resected-non-small-cell-lung-cancer
#6
Shigeki Sawada, Ryujiro Sugimoto, Tsuyoshi Ueno, Motohiro Yamashita
We evaluated the feasibility of maintenance treatment using UFT (a combination of tegafur and uracil) after adjuvant platinum-based chemotherapy in patients with resected lung cancer. A prospective feasibility trial was conducted. Between 2010 and 2014, UFT was administered for 2 years sequentially after platinum-based adjuvant chemotherapy in 24 patients with resected Stage IIA-IIIA non-small cell lung cancer. The safety of UFT and the rate of treatment completion were then evaluated. The prior platinum-based chemotherapy regimens consisted of cisplatin+vinorelbine in 16 patients, carboplatin+paclitaxel in 5 and carboplatin+S-1 in one...
December 2017: Acta Medica Okayama
https://www.readbyqxmd.com/read/29243164/effects-of-exercise-during-chemotherapy-on-chemotherapy-induced-peripheral-neuropathy-a-multicenter-randomized-controlled-trial
#7
Ian R Kleckner, Charles Kamen, Jennifer S Gewandter, Nimish A Mohile, Charles E Heckler, Eva Culakova, Chunkit Fung, Michelle C Janelsins, Matthew Asare, Po-Ju Lin, Pavan S Reddy, Jeffrey Giguere, Jeffrey Berenberg, Shelli R Kesler, Karen M Mustian
PURPOSE: Over half of all cancer patients receiving taxane-, platinum-, or vinca alkaloid-based chemotherapy experience chemotherapy-induced peripheral neuropathy (CIPN), which includes numbness, tingling, pain, cold sensitivity, and motor impairment in the hands and feet. CIPN is a dose-limiting toxicity, potentially increasing mortality. There are no FDA-approved drugs to treat CIPN, and behavioral interventions such as exercise are promising yet understudied. This secondary analysis of our nationwide phase III randomized controlled trial of exercise for fatigue examines (1) effects of exercise on CIPN symptoms, (2) factors that predict CIPN symptoms, and (3) factors that moderate effects of exercise on CIPN symptoms...
December 14, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29230086/psychometric-study-of-the-pain-drawing
#8
Lisa H Trahan, Emily Cox-Martin, Carrie E Johnson, Patrick M Dougherty, Jun Yu, Lei Feng, Christina Cook, Diane M Novy
Purpose: The objectives of the study were to (1) assess the extent to which interrater reliability of pain drawing location and dispersion scoring methods are similar across pain disciplines in a sample of patients with cancer treatment-induced neuropathic pain (N = 56) and (2) investigate indicators of validity of the pain drawing in this unique sample. Methods: Patients undergoing cancer therapy completed the Brief Pain Inventory Body Map, the MD Anderson Symptom Inventory, and the McGill Pain Questionnaire...
December 2017: Journal of Applied Biobehavioral Research
https://www.readbyqxmd.com/read/29228576/comparison-of-tumor-biology-of-two-distinct-cell-sub-populations-in-lung-cancer-stem-cells
#9
Jianyu Wang, Zhiwei Sun, Yongli Liu, Liangsheng Kong, Shixia Zhou, Junlin Tang, Hongmei Rosie Xing
Characterization of the stem-like properties of cancer stem cells (CSCs) remain indirect and qualitative, especially the ability of CSCs to undergo asymmetric cell division for self renewal and differentiation, a unique property of cells of stem origin. It is partly due to the lack of stable cellular models of CSCs. In this study, we developed a new approach for CSC isolation and purification to derive a CSC-enriched cell line (LLC-SE). By conducting five consecutive rounds of single cell cloning using the LLC-SE cell line, we obtained two distinct sub-population of cells within the Lewis lung cancer CSCs that employed largely symmetric division for self-renewal (LLC-SD) or underwent asymmetric division for differentiation (LLC-ASD)...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29222203/type-and-frequency-of-side-effects-during-pc6-acupuncture-observations-from-therapists-and-patients-participating-in-clinical-efficacy-trials-of-acupuncture
#10
Anna Enblom, Anna Johnsson
BACKGROUND: Many therapists practise PC6 acupuncture for emesis (nausea and vomiting) during pregnancy, different cancer therapies, palliative care, after surgery, or to induce relaxing effects in general. Knowledge of side effects is central to shared decision-making. AIM: To describe the type and frequency of side effects and the level of needle-induced pain during PC6 acupuncture. METHODS: We included 1298 PC6 acupuncture treatments, delivered to 221 participants (77% women, mean age 52...
December 2017: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29221848/menopausal-related-symptoms-in-women-one-year-after-breast-cancer-surgery
#11
Melissa Mazor, Kathryn Lee, Anand Dhruva, Janine K Cataldo, Steven M Paul, Michelle Melisko, Betty J Smoot, Jon D Levine, Charles Elboim, Yvette P Conley, Christine Miaskowksi
CONTEXT: Approximately 60% to 100% of women with breast cancer experience at least one menopausal-related symptom. Little is known about associations between menopausal status and symptoms in women 12 months after breast cancer surgery. OBJECTIVE: Purpose of this study was to evaluate for differences in occurrence, severity, and distress of symptoms between pre- and post-menopausal women 12 months after breast cancer surgery. METHODS: Women with breast cancer (n=327) completed the Menopausal Symptoms Scale, that evaluated the occurrence, severity, and distress of 46 common menopausal-related symptoms...
December 5, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29190716/suppression-of-cancer-stemness-by-upregulating-ligand-of-numb-protein-x1-in-colorectal-carcinoma
#12
Lin Ma, Lan Wang, Yating Shan, Muhammad Nafees, Elshoura Ihab, Ruhui Zhang, Fangjun Wang, Wu Yin
Cancer stem-like cells (CSCs) have been reported to play major roles in tumorigenesis, tumor relapse, and metastasis after therapy against colorectal carcinoma (CRC). Therefore, identification of colorectal CSC regulators could provide promising targets for CRC. Ligand-of-Numb protein X1 (LNX1) is one E3 ubiquitin ligase which mediates the ubiquitination and degradation of Numb. Although several studies indicate LNX1 could be a potential suppressor of cancer diseases, the functions of LNX1 in mediating cancer stemness remain poorly understood...
2017: PloS One
https://www.readbyqxmd.com/read/29187638/numb-prevents-a-complete-epithelial-mesenchymal-transition-by-modulating-notch-signalling
#13
Federico Bocci, Mohit K Jolly, Satyendra C Tripathi, Mitzi Aguilar, Samir M Hanash, Herbert Levine, José N Onuchic
Epithelial-mesenchymal transition (EMT) plays key roles during embryonic development, wound healing and cancer metastasis. Cells in a partial EMT or hybrid epithelial/mesenchymal (E/M) phenotype exhibit collective cell migration, forming clusters of circulating tumour cells-the primary drivers of metastasis. Activation of cell-cell signalling pathways such as Notch fosters a partial or complete EMT, yet the mechanisms enabling cluster formation remain poorly understood. Using an integrated computational-experimental approach, we examine the role of Numb-an inhibitor of Notch intercellular signalling-in mediating EMT and clusters formation...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29126536/a-53-year-old-man-with-a-bronchial-mass-and-multiple-bone-lesions
#14
Sujith V Cherian, Rosa M Estrada-Y-Martin, Shahreen Billah, Annikka Weissferdt
A 53-year-old man was admitted with complaints of back pain of 3 months' duration along with numbness and weakness in his left upper and lower extremities. He denied any respiratory complaints or anorexia but did report an 11 kg weight loss over the last 3 months. He had no other significant medical history and denied any history of cigarette smoking or recreational drug use. Family history was significant for prostate cancer in his father.
November 2017: Chest
https://www.readbyqxmd.com/read/29108922/use-of-erlotinib-and-thalidomide-in-advanced-nsclc-patients-with-acquired-resistance-to-erlotinib-a-pilot-study
#15
Gen-He Wang, Peng-Fei Wu, Long-Hui Zhang, Ping Fang, Yong Chen, Gang Zuo, Yi-Qing Wu, Shu-Hong Wang, Guo-Ping Sun
Evidences suggested that combined blockade of the VEGF and EGFR pathways can improve the treatment efficacy of non-small-cell lung cancer (NSCLC). In our previously clinical practice, we observed that thalidomide, a potent VEGF inhibitor, can significantly decrease the tumor size of one EGFR-TKI resistance patient with lung cancer cachexia. In this pilot study, we tried to assess the efficacy and toxicity of the combination therapy of erlotinib and thalidomide in advanced NSCLC patients with acquired resistance to erlotinib...
October 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29102296/sacral-neuromodulation-for-faecal-incontinence-10-years-experience-at-a-scottish-tertiary-centre
#16
Hoey Koh, Stephen McSorley, Sarah Hunt, Martha Quinn, Graham MacKay, John Anderson
INTRODUCTION: Sacral nerve stimulation (SNS) is increasingly popular in the management of faecal incontinence. This paper reports the first 10-year experience of SNS in the management of faecal incontinence at a tertiary referral centre. Data was collected in a prospectively maintained database. RESULTS: In total 130 patients were referred. The majority were women (94%) under 75-year-old (98%). Seven patients were found to have full-thickness rectal prolapse at the initial work-up and proceeded to rectopexy...
October 25, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29059161/plk1-phosphorylation-of-numb-leads-to-impaired-dna-damage-response
#17
C Shao, S-J Chien, E Farah, Z Li, N Ahmad, X Liu
Although Numb is well-recognized as a cell-fate determinant in stem/progenitor cells, accumulating evidence supports that Numb also has a critical role in adult tissues and cancers, in particular, in the context of regulation of tumor suppressor p53. Herein, we identified Numb as a novel substrate of Polo-like kinase 1 (Plk1). Of significance, we showed that Plk1-mediated phosphorylation of Numb leads to its enhanced proteasomal degradation and impaired Numb/p53 pathway, thus providing another mechanism how Plk1 antagonizes p53 during DNA damage response...
October 23, 2017: Oncogene
https://www.readbyqxmd.com/read/29051114/changes-in-the-occurrence-severity-and-distress-of-symptoms-in-patients-with-gastrointestinal-cancers-receiving-chemotherapy
#18
Ilufredo Y Tantoy, Bruce A Cooper, Anand Dhruva, Janine Cataldo, Steven M Paul, Yvette P Conley, Marilyn Hammer, Fay Wright, Laura B Dunn, Jon D Levine, Christine Miaskowski
CONTEXT: Studies on multiple dimensions of the symptom experience of patients with gastrointestinal cancers are extremely limited. OBJECTIVE: Purpose was to evaluate for changes over time in the occurrence, severity, and distress of seven common symptoms in these patients. METHODS: Patients completed Memorial Symptom Assessment Scale, six times over two cycles of chemotherapy (CTX). Changes over time in occurrence, severity, and distress of pain, lack of energy, nausea, feeling drowsy, difficulty sleeping, and change in the way food tastes were evaluated using multilevel regression analyses...
October 17, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29031308/quality-of-life-among-korean-gastrointestinal-cancer-survivors
#19
Soojung Ahn, Hyejeong Jung, Sanghee Kim, Sang Joon Shin, Chang Gi Park, Sang Hui Chu
PURPOSE: The number of gastrointestinal (GI) cancer survivors has been steadily increasing owing to early diagnosis and improved cancer treatment outcomes. The quality of life (QoL) of cancer survivors can provide distinct prognostic information and represent their functioning. This study aimed to investigate the levels of symptoms, psychological distress, and QoL of GI cancer survivors, and identify factors associated with QoL. METHOD: A cross-sectional survey was conducted among 145 survivors of gastric or colorectal cancer in a university-affiliated hospital, Seoul, South Korea...
October 2017: European Journal of Oncology Nursing: the Official Journal of European Oncology Nursing Society
https://www.readbyqxmd.com/read/29019888/an-upper-cervical-cord-compression-secondary-to-occult-follicular-thyroid-carcinoma-metastases-successfully-treated-with-multiple-radioiodine-therapies-a-clinical-case-report
#20
Ping Dong, Ni Chen, Lin Li, Rui Huang
RATIONALE: The spine is the most common site of bone metastases due to thyroid cancer; however, spinal cord compression as a complication of metastatic thyroid cancer is very rare. PATIENT CONCERNS: A 48-year-old female patient was presented to the Neurosurgical Department, complaining of progressive back neck pain with bilateral upper extremities numbness and weakness for 4 months. DIAGNOSIS: Imaging studies revealed osteolytic destruction in bodies and accessories of the second and third cervical vertebrae with a huge soft-tissue mass compressing spinal cord and causing swelling...
October 2017: Medicine (Baltimore)
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