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https://www.readbyqxmd.com/read/27920702/esophageal-cancer-with-bone-marrow-hyperplasia-mimicking-bone-metastasis-report-of-a-case
#1
Hiromi Yasuda, Tadanobu Shimura, Masato Okigami, Shigeyuki Yoshiyama, Masaki Ohi, Koji Tanaka, Yasuhiko Mohri, Masato Kusunoki
A 63-year-old man visited the clinic with numbness in the right hand. Magnetic resonance imaging demonstrated multiple low-intensity lesions in the cervical vertebrae and sacrum, which was suspicious of cervical bone metastasis. Fluorodeoxyglucose positron emission tomography/computed tomography revealed areas of increased fluorodeoxyglucose uptake in the thoracic esophagus, sternum and sacrum. A flat, elevated esophageal cancer was identified by upper gastrointestinal endoscopy, and the macroscopic appearance indicated early-stage disease...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27916037/-relationship-and-clinicopathological-significance-of-numb-and-epithelial-mesenchymal-transition-related-proteins-in-human-pancreatic-cancer
#2
W W Sheng, M Dong, Z R Liu, Y J Li, J P Zhou, Q Dong
Objective: To study the relationship and clinicopathological significance of Numb and epithelial-mesenchymal transition related proteins in human pancreatic cancer(PC). Methods: Sixty-three cases of pancreatic cancer tissues were obtained from department of gastrointestinal surgery in the First Hospital of China Medical University from January 2005 to December 2012, all samples were histopathologically proved to be adenocarcinoma. The expressions of Numb, E-cadherin and Vimentin proteins in 63 cases of pancreatic cancer specimens were detected by immunohistochemistry...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27882251/bilateral-numb-chin-syndrome-as-the-initial-presentation-of-burkitt-s-lymphoma-leukemia-a-report-of-two-cases-and-review-of-the-literature
#3
Hussein Algahtani, Bader Shirah, Wafaa Bassuni, Reem Adas
Numb chin syndrome, also known as mental nerve neuropathy, is a rare sensory neuropathy characterized by paresthesia and hypoesthesia in the area supplied by the mental nerve and its branches. This syndrome may be the first symptom of underlying malignancy or the first sign of recurrence and metastasis in patients with preexisting cancer. In this article, we present two cases with bilateral numb chin syndrome as the first manifestation of Burkitt's lymphoma/leukemia and review the relevant literature. Numb chin syndrome should be considered as a warning sign and raise the suspicion for an underlying malignancy...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/27854104/new-practical-approaches-to-chemotherapy-induced-neuropathic-pain-prevention-assessment-and-treatment
#4
REVIEW
Neil Majithia, Charles L Loprinzi, Thomas J Smith
Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most disabling and demoralizing problems that arise for cancer survivors. When investigating symptoms of numbness, tingling, or pain in the extremities, it is critical to determine whether the problem is neuropathic, somatic, or mixed. If the diagnosis is CIPN, it is important to weigh the potential benefits and harms of possible treatment options, and to devise an evidence-based multimodality treatment program. Such programs may include mixtures of opioid and nonopioid adjunctive medications, based on evidence from CIPN trials, and also extrapolation from trials in patients with other neuropathic pain syndromes-although such extrapolating must be done with caution, since other syndromes sometimes respond to agents that CIPN does not respond to...
November 15, 2016: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/27824903/mir-146a-polymorphism-rs2910164-predicts-colorectal-cancer-patients-susceptibility-to-liver-metastasis
#5
Tomohiro Iguchi, Sho Nambara, Takaaki Masuda, Hisateru Komatsu, Masami Ueda, Shinya Kidogami, Yushi Ogawa, Qingjiang Hu, Kuniaki Sato, Tomoko Saito, Hidenari Hirata, Shotaro Sakimura, Ryutaro Uchi, Naoki Hayashi, Shuhei Ito, Hidetoshi Eguchi, Keishi Sugimachi, Yoshihiko Maehara, Koshi Mimori
miR-146a plays important roles in cancer as it directly targets NUMB, an inhibitor of Notch signaling. miR-146a is reportedly regulated by a G>C polymorphism (SNP; rs2910164). This polymorphism affects various cancers, including colorectal cancer (CRC). However, the clinical significance of miR-146a polymorphism in CRC remains unclear. A total of 59 patients with CRC were divided into 2 groups: a CC/CG genotype (n = 32) and a GG genotype (n = 27), based on the miR-146a polymorphism. cDNA microarray analysis was performed using 59 clinical samples...
2016: PloS One
https://www.readbyqxmd.com/read/27803912/efficacy-of-japanese-traditional-kampo-medicine-for-treating-chemotherapy-induced-peripheral-neuropathy-a-retrospective-case-series-study
#6
Yumiko Kimata, Keiko Ogawa, Hideki Okamoto, Atsushi Chino, Takao Namiki
AIM: To investigate Japanese traditional (Kampo) medicine's effectiveness on cancer chemotherapy-induced peripheral neuropathy (CIPN), we carried out this retrospective study. METHODS: By searching our outpatient database of 3154 patients who consulted our outpatient clinic of Japanese-Oriental (Kampo) Medicine at Chiba University Hospital from November 2005 to December 2010, a total of 281 patients diagnosed with cancer were identified. Twenty-four patients out of the 281 patients identified met the following three conditions and were eligible for further investigation of the effectiveness of Kampo treatment: At least one course of cancer chemotherapy had been administered; numbness and pain appeared after the chemotherapy; and CIPN was diagnosed before they were given Kampo treatment...
October 16, 2016: World Journal of Clinical Cases
https://www.readbyqxmd.com/read/27798187/cd8-t-cells-and-endogenous-il-10-are-required-for-resolution-of-chemotherapy-induced-neuropathic-pain
#7
Karen Krukowski, Niels Eijkelkamp, Geoffroy Laumet, C Erik Hack, Yan Li, Patrick M Dougherty, Cobi J Heijnen, Annemieke Kavelaars
: Chemotherapy-induced peripheral neuropathy (CIPN), characterized by pain and numbness in hands and feet, is a common side effect of cancer treatment. In most patients, symptoms of CIPN subside after treatment completion. However, in a substantial subgroup, CIPN persists long into survivorship. Impairment in pain resolution pathways may explain persistent CIPN. We investigated the contribution of T cells and endogenous interleukin (IL)-10 to resolution of CIPN. Paclitaxel-induced mechanical allodynia was prolonged in T-cell-deficient (Rag1(-/-)) mice compared with wild-type (WT) mice...
October 26, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27771479/surgical-management-for-destructive-atlantoaxial-spondyloarthropathy-in-long-term-hemodialysis-patients
#8
Je Hoon Jeong, Hee Kyung Kim, Soo Bin Im
BACKGROUND: Atlantoaxial spondyloarthropathy is most often resulted from rheumatoid arthritis, cancer metastasis and basilar invagination. Dialysis-related spondyloarthropathy is a rare cause of spinal deformity and cervical myelopathy at the atlantoaxial joint. We report two long-term hemodialysis patients who presented with atlantoaxial spondyloarthropathy. CASE DESCRIPTION: Two patients with end-stage renal failure (ESRD) presented with history of progressively worsening neck pain and motion limitation, and gait disturbance...
October 19, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27770268/sensitizing-effect-of-juglone-is-mediated-by-down-regulation-of-notch1-signaling-pathway-in-trastuzumab-resistant-skbr3-cells
#9
Soraya Sajadimajd, Razieh Yazdanparast
Trastuzumab (Herceptin) monoclonal antibody directed against HER2 receptor has been administered as a treatment for metastatic HER2 positive breast cancer. The problematic issue in treatment of HER2 positive breast cancer cells is commonly the induction of resistance to trastuzumab which might be due to modulation of some vital signaling elements such as Notch1 and Pin1. In this study, we were aimed to investigate whether the cross talk between pin1 and Notch1 has a role in this event. Our results indicated that the expression level of Pin1 in resistant SKBR3 cells increased by about twofold relative to sensitive SKBR3 cells...
October 21, 2016: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/27767110/oral-cryotherapy-reduced-oral-mucositis-in-patients-having-cancer-treatments
#10
Sylvia Spivakovsky
Data sourcesCochrane Oral Health Group Trials Register, Cochrane Central Register of Controlled Trials (CENTRAL), Medline, Embase, CANCERLIT, CINAHL, the US National Institutes of Health Trials Registry and the WHO Clinical Trials Registry Platform.Study selectionRandomised controlled trials (RCTs) assessing the effects of oral cryotherapy in patients with cancer receiving treatment compared to usual care, no treatment or other interventions to prevent mucositis. The primary outcome was incidence of mucositis and its severity...
September 2016: Evidence-based Dentistry
https://www.readbyqxmd.com/read/27756521/the-course-of-neuropathic-symptoms-in-relation-to-adjuvant-chemotherapy-among-elderly-patients-with-stage-iii-colon-cancer-a%C3%A2-longitudinal-study
#11
Felice N van Erning, Maryska L G Janssen-Heijnen, Johannes A Wegdam, Gerrit D Slooter, Jan H Wijsman, Art Vreugenhil, Tonneke A J M Beijers, Lonneke V van de Poll-Franse, Valery E P P Lemmens
INTRODUCTION: Among the elderly, the impairment of functional capacities due to neuropathy can have a significant impact. The aim of the present study was to investigate the course of neuropathic symptoms among elderly patients with stage III colon cancer treated with CAPOX (capecitabine, oxaliplatin), capecitabine monotherapy, or no adjuvant chemotherapy. MATERIALS AND METHODS: The Netherlands Cancer Registry was used to select patients with stage III colon cancer and aged ≥ 70 years...
September 17, 2016: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/27749585/a-case-report-of-the-beneficial-effects-of-botulinum-toxin-type-a-on-raynaud-phenomenon-in-a-patient-with-lung-cancer
#12
Lu Wang, Qi-Song Lei, Yu-Ying Liu, Guan-Jie Song, Chun-Ling Song
OBJECTIVE: Raynaud phenomenon is a vasospastic disorder affecting the hands and feet, and the efficacies of traditional treatments, such as pharmacological therapies and sympathectomy, are not uniform. Patients with paraneoplastic Raynaud phenomenon do not benefit from the traditional treatments. The use of botulinum toxin type A (BTX-A) for Raynaud phenomenon has been reported for several years; however, there are few reports regarding botulinum toxin type A in the treatment of paraneoplastic Raynaud phenomenon...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27749531/application-of-radiofrequency-thermocoagulation-combined-with-adriamycin-injection-in-dorsal-root-ganglia-for-controlling-refractory-pain-induced-by-rib-metastasis-of-lung-cancer-a-strobe-compliant-article
#13
Guang-Lun Xie, Da-Peng Guo, Zhi-Gang Li, Chang Liu, Wei Zhang
This study aimed to observe the therapeutic effects and adverse reactions of radiofrequency thermocoagulation combined with adriamycin injection in dorsal root ganglia on lung cancer rib metastasis-related refractory pain which has no response to conventional therapy.This study contained 27 patients with lung cancer rib metastasis-related moderate or severe pain which had no response to conventional therapy. Under computed tomography (CT)-guidance, radiofrequency puncture need reached the corresponding intervertebral foramens to ensure needle point near dorsal root ganglia (DRG) by sensory and motor stimulation tests, and then radiofrequency thermocoagulation was performed on each corresponding DRG followed by injection of 0...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27724870/sakk-24-09-safety-and-tolerability-of-bevacizumab-plus-paclitaxel-vs-bevacizumab-plus-metronomic-cyclophosphamide-and-capecitabine-as-first-line-therapy-in-patients-with-her2-negative-advanced-stage-breast-cancer-a-multicenter-randomized-phase-iii-trial
#14
Christoph Rochlitz, Martin Bigler, Roger von Moos, Jürg Bernhard, Klazien Matter-Walstra, Andreas Wicki, Khalil Zaman, Sandro Anchisi, Marc Küng, Kyung-Jae Na, Daniela Bärtschi, Markus Borner, Tamara Rordorf, Daniel Rauch, Andreas Müller, Thomas Ruhstaller, Marcus Vetter, Andreas Trojan, Ursula Hasler-Strub, Richard Cathomas, Ralph Winterhalder
BACKGROUND: Adding bevacizumab to chemotherapy improves response rates and progression-free survival (PFS) in metastatic breast cancer (mBC). We aimed to demonstrate decreased toxicity with metronomic chemotherapy/bevacizumab compared with paclitaxel/bevacizumab. METHODS: This multicenter, randomized phase III trial compared bevacizumab with either paclitaxel (arm A) or daily oral capecitabine-cyclophosphamide (arm B) as first-line treatment in patients with HER2-negative advanced breast cancer...
October 10, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27677287/numb-notch-signaling-pathway-modulation-enhances-human-pancreatic-cancer-cell-radiosensitivity
#15
Yi-Liang Bi, Min Min, Wei Shen, Yan Liu
The present study aims to evaluate whether repression of the Numb/Notch signaling pathway affects the radiosensitivity of human pancreatic cancer cell lines. Different doses of X-rays (0, 2, 3, 4, and 5 Gy) were applied to the PANC-1, SW1990, and MIA PaCa-2 human pancreatic cancer cell lines, and the Numb/Notch pathway inhibitor DAPT was added at different doses (0, 1, 3, and 5 μmol/l). MTT assay, colony formation assay, flow cytometry, scratch assay, and Transwell experiments were performed, and qRT-PCR and Western blot were conducted for the detection of Numb expression...
September 27, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/27652318/asymmetric-division-an-antitumor-player
#16
Lihua Wang, Pengcheng Bu, Xiling Shen
miR-34a-mediated asymmetric cell division reins in excessive stem cell expansion during tissue regeneration in the intestine and colon. Loss of miR-34a switches asymmetric division to symmetric division and enhances stem cell proliferation. Asymmetric division also occurs in the early stages of colon cancer stem cells. Mechanistically, miR-34a, Numb, and Notch form a feed-forward loop that specifies cell fate when stem cells divide.
July 2016: Molecular & Cellular Oncology
https://www.readbyqxmd.com/read/27634768/src-oncogene-induces-trop2-proteolytic-activation-via-cyclin-d1
#17
Xiaoming Ju, Xuanmao Jiao, Adam Ertel, Mathew C Casimiro, Gabriele Di Sante, Shengqiong Deng, Zhiping Li, Agnese Di Rocco, Tingting Zhan, Adam Hawkins, Tanya Stoyanova, Sebastiano Ando, Alessandro Fatatis, Michael P Lisanti, Leonard G Gomella, Lucia R Languino, Richard G Pestell
Proteomic analysis of castration-resistant prostate cancer demonstrated the enrichment of SRC tyrosine kinase activity in approximately ninety percent of patients. Src is known to induce cyclin D1, and a cyclin D1-regulated gene expression module predict poor outcome in human prostate cancer. The tumor-associated calcium signal transducer 2 [TACSTD2/Trop2/M1S1] is enriched in the prostate, promoting prostate stem cell self-renewal upon proteolytic activation via a γ-secretase cleavage complex (PS1, PS2) and TACE (ADAM17), which releases the Trop2 intracellular domain (Trop2 ICD)...
September 15, 2016: Cancer Research
https://www.readbyqxmd.com/read/27617728/unilateral-indurated-plaque-in-the-axilla-a-case-of-metastatic-breast-carcinoma
#18
Devorah Shagalov, Michelle Xu, Tracey Liebman, Gina Taylor
Breast cancer is the most commonly diagnosed cancer among American women and is also the most common internal malignancy to metastasize to the skin. Rarely, cutaneous metastases represent the first indication of breast carcinoma, putting dermatologists in an instrumental position to make the diagnosis of breast carcinoma. We report the case of a 71-year-old woman with a 10-year history of a slowly-enlarging, indurated plaque in the right axilla. Review of symptoms was significant only for occasional numbness and tingling that extended from the right axilla to the right hand...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27617103/leptomeningeal-carcinomatosis-in-non-small-cell-lung-cancer-initial-response-to-erlotinib-followed-by-relapse-despite-continuing-radiological-resolution-of-disease
#19
Alvin J X Lee, Rachel Benamore, Monika Hofer, Meenali Chitnis
A 60-year-old male was diagnosed with T3, N3, M1b epidermal growth factor receptor (EGFR) mutant lung adenocarcinoma. Five months later he developed significant headaches, weakness and numbness of the left leg, and unsteadiness of gait. Magnetic resonance imaging (MRI) brain demonstrated subtle gyral enhancement indicative of early leptomeningeal infiltration. He was commenced on second-line erlotinib which improved his lower limb symptoms. Three months later he developed increased urinary frequency and redeveloped leg symptoms...
September 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/27613838/numb-like-numbl-downregulation-increases-tumorigenicity-cancer-stem-cell-like-properties-and-resistance-to-chemotherapy
#20
José M García-Heredia, Eva M Verdugo Sivianes, Antonio Lucena-Cacace, Sonia Molina-Pinelo, Amancio Carnero
NumbL, or Numb-like, is a close homologue of Numb, and is part of an evolutionary conserved protein family implicated in some important cellular processes. Numb is a protein involved in cell development, in cell adhesion and migration, in asymmetric cell division, and in targeting proteins for endocytosis and ubiquitination. NumbL exhibits some overlapping functions with Numb, but its role in tumorigenesis is not fully known. Here we showed that the downregulation of NumbL alone is sufficient to increase NICD nuclear translocation and induce Notch pathway activation...
August 23, 2016: Oncotarget
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