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https://www.readbyqxmd.com/read/29747452/cytokeratin-19-krt19-has-a-role-in-the-reprogramming-of-cancer-stem-cell-like-cells-to-less-aggressive-and-more-drug-sensitive-cells
#1
Subbroto Kumar Saha, Kyeongseok Kim, Gwang-Mo Yang, Hye Yeon Choi, Ssang-Goo Cho
Cytokeratin 19 ( KRT19 ) is a cytoplasmic intermediate filament protein, which is responsible for structural rigidity and multipurpose scaffolds. In several cancers, KRT19 is overexpressed and may play a crucial role in tumorigenic transformation. In our previous study, we revealed the role of KRT19 as signaling component which mediated Wnt/NOTCH crosstalk through NUMB transcription in breast cancer. Here, we investigated the function of KRT19 in cancer reprogramming and drug resistance in breast cancer cells...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29725799/the-timeliness-of-patients-reporting-the-side-effects-of-chemotherapy
#2
Ian Olver, Mariko Carey, Allison Boyes, Alix Hall, Natasha Noble, Jamie Bryant, Justin Walsh, Rob Sanson-Fisher
PURPOSE: To explore the actions cancer patients reported they would take in response to a range of common side effects of chemotherapy and whether these were considered appropriate based on current guidelines and evidence; and to explore the sociodemographic and cancer-related variables associated with patients selecting the appropriate action (immediate medical attention or reporting) for two potentially life-threatening side effects: fever, and unusual bleeding and bruising. METHODS: Four hundred thirty-six medical oncology and haematology patients receiving chemotherapy completed two surveys to provide demographic, disease and treatment characteristics, and details on how they would respond if they experienced a range of specified side effects of chemotherapy (for example, nausea and vomiting, fatigue, and skin rash or nail changes)...
May 3, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29721811/life-quality-of-patients-who-underwent-breast-reconstruction-after-prophylactic-mastectomy-systematic-review
#3
REVIEW
Dilek Aygin, Hande Cengiz
BACKGROUND: Prophylactic mastectomy is used to reduce the incidence of breast cancer in women with genetic predisposition and family history of breast cancer, and the rate of application is increased nowadays. Chronic pain, body image, and sexuality may negatively affect quality of life, while patients generally have increased quality of life and satisfaction after prophylactic mastectomy. The aim of this study is the evaluation of the results of the studies about quality of life of patients who underwent breast reconstruction after prophylactic mastectomy...
May 2, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29721172/loss-of-nuclear-notch1-but-not-its-negative-regulator-numb-is-an-independent-predictor-of-cervical-malignancy
#4
Elenaé Vázquez-Ulloa, Ana Clara Ramos-Cruz, Diddier Prada, Alejandro Avilés-Salas, Alma Delia Chávez-Blanco, Luis A Herrera, Marcela Lizano, Adriana Contreras-Paredes
The participation of NOTCH signaling in invasive cervical cancer (ICC) remains controversial since both tumor suppressive and oncogenic properties have been described. Additionally, the role of NUMB, a negative regulator of NOTCH, remains unclear in ICC. We aimed to investigate the role of NOTCH1 and NUMB expression and their localization in cervical intraepithelial neoplasia (CIN) and ICC samples. A total of 144 biopsies were obtained from the Instituto Nacional de Cancerología, México from 2004 to 2017, and were subjected to immunohistochemistry for NOTCH1 and NUMB...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29718880/various-clinical-features-of-patients-with-anti-hu-associated-paraneoplastic-neurological-syndromes-an-observational-study
#5
Jia Li, Weihong Lin
To describe and analyze the clinical features and prognosis of patients with anti-Hu associated paraneoplastic neurological syndromes (PNS).The symptoms, MRI findings, cerebrospinal fluid (CSF) changes, electroencephalogram (EEG) characteristics and prognoses of 9 well-diagnosed anti-Hu associated PNS patients were analyzed.The study enrolled 6 female and 3 male patients. Three patients presented with vertigo and 6 patients exhibited a depressed mood, numbness of the lower limbs, generalized pains, seizures, mental disturbances, and a temporary unilateral hand tremor on initial presentation...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29680775/numb-chin-syndrome-a-reflection-of-malignancy-or-a-harbinger-of-mronj-a-multicenter-experience
#6
Leonzio Fortunato, Massimo Amato, Michele Simeone, Francesco Bennardo, Selene Barone, Amerigo Giudice
INTRODUCTION: Numb chin syndrome (NCS) or mental neuropathy (MN) is a disorder characterized by sensory neuropathy on the distribution of the inferior alveolar nerve or mental nerve. The most frequent causes are of odontogenic origin (infections, wrong therapies). Other etiologies are related to primary tumor, metastasis, osteoradionecrosis and medication-related osteonecrosis of the jaw (MRONJ). The aim of this study is to highlight the clinical importance of NCS as one of the first symptoms of cancer or as consequence of drug therapy...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29602320/pre-treatment-anxiety-is-associated-with-persistent-chemotherapy-induced-peripheral-neuropathy-in-women-treated-with-neoadjuvant-chemotherapy-for-breast-cancer
#7
Kwang-Min Lee, Dooyoung Jung, Heesung Hwang, Kyung-Lak Son, Tae-Yong Kim, Seock-Ah Im, Kyung-Hun Lee, Bong-Jin Hahm
OBJECTIVE: Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent adverse reaction caused by chemotherapeutic agents, especially the taxanes. CIPN can persist from months to years after completion of chemotherapy, decreasing quality of life for cancer survivors. The aim of this study was to explore the incidence and risk factors of persistent CIPN among women with breast cancer receiving neoadjuvant chemotherapy. METHODS: In this prospective study, we recruited women with breast cancer receiving neoadjuvant chemotherapy, including four cycles of docetaxel...
May 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29581274/loss-of-tdp43-inhibits-progression-of-triple-negative-breast-cancer-in-coordination-with-srsf3
#8
Hao Ke, Limin Zhao, Honglei Zhang, Xu Feng, Haibo Xu, Junjun Hao, Shaowei Wang, Qin Yang, Li Zou, Xiaosan Su, Liqiong Wang, Chunlian Wu, Yang Wang, Jianyun Nie, Baowei Jiao
Aberrant alternative splicing has been highlighted as a potential hallmark of cancer. Here, we identify TDP43 (TAR DNA-binding protein 43) as an important splicing regulator responsible for the unique splicing profile in triple-negative breast cancer (TNBC). Clinical data demonstrate that TDP43 is highly expressed in TNBC with poor prognosis. Knockdown of TDP43 inhibits tumor progression, including proliferation and metastasis, and overexpression of TDP43 promotes proliferation and malignancy of mammary epithelial cells...
March 26, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29561303/effect-of-a-complementary-integrative-medicine-treatment-program-on-taxane-induced-peripheral-neuropathy-a-brief-report
#9
Eran Ben-Arye, Yaron River, Yael Keshet, Ofer Lavie, Pesi Israeli, Noah Samuels
OBJECTIVE: Peripheral neuropathy is a common complication of cancer treatment impairing quality of life and function. This study explored the impact of a complementary and integrative medicine (CIM) program on taxane-induced peripheral neuropathy (TIPN). MATERIALS AND METHODS: Taxane-treated female patients with breast and gynecological cancer reporting TIPN-related symptoms were referred to an integrative physician, followed by patient-tailored CIM treatments (acupuncture with/without other modalities)...
June 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29551249/estimating-the-reliability-and-validity-of-the-upper-extremity-functional-index-in-women-after-breast-cancer-surgery
#10
Jill M Binkley, Paul Stratford, Stephanie Kirkpatrick, Clara R Farley, Joel Okoli, Sheryl Gabram
BACKGROUND: Activity limitations as well as impairments such as pain, numbness, limitation of shoulder range of motion, and weakness are common and well documented during and after treatment for breast cancer. There is limited information regarding the measurement properties of patient-reported outcome measures of upper extremity activity limitation in this population. This study examined the reliability and validity of the Upper Extremity Functional Index (UEFI) in patients after surgery for breast cancer...
February 21, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29540660/cheek-numbness-caused-by-perineural-tumor-invasion-of-the-infraorbital-nerve-a-review-of-3-diagnostically-challenging-cases
#11
Cecilie Okholm, Martin Frendø, Katalin Kiss, Christian von Buchwald
BACKGROUND Facial pain and numbness are common symptoms with a variety of causes; rarely, it is an initial sign of perineural infiltration of malignant tumors. CASE REPORT Here, we report 3 challenging cases, all presenting with pain and numbness of the cheek as the primary symptoms. Upon referral, there were neither signs of severe illness nor information about previous malignant diseases, while the diagnostic work-ups revealed additional involvement of the facial nerve in 2 of the cases. Surgical removal of the perineural tissue around the infraorbital nerve revealed perineural invasion by a squamous carcinoma...
March 15, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29507685/numb-and-numbl-differences-in-gene-regulation
#12
José Manuel García-Heredia, Amancio Carnero
NUMB, and its close homologue NUMBL, behave as tumor suppressor genes by regulating the Notch pathway. The downregulation of these genes in tumors is common, allowing aberrant Notch pathway activation and tumor progression. However, some known differences between NUMB and NUMBL have raised unanswered questions regarding the redundancy and/or combined regulation of the Notch pathway by these genes during the tumorigenic process. We have found that NUMB and NUMBL exhibit mutual exclusivity in human tumors, suggesting that the associated tumor suppressor role is regulated by only one of the two proteins in a specific cell, avoiding duplicate signaling and simplifying the regulatory network...
February 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29503168/multiple-thrombi-in-the-heart-in-trousseau-syndrome-caused-by-pancreatic-carcinoma
#13
Sho Takeshita, Toshiyasu Ogata, Hidekazu Mera, Jun Tsugawa, Mikiko Aoki, Morishige Takeshita, Yoshio Tsuboi
A 65-year-old woman presented to our emergency room because of sudden onset of right hemiparesis with severe fatigue. Neurological examination revealed right hemiparesis with right facial numbness and an extensor planter response on the right side.Magnetic resonance imaging with diffusion-weighted imaging revealed multiple highintensity areas in both cerebral hemispheres and the right cerebellum. A diagnosis of acute stage of multiple brain infarctions caused by emboli was made. An abdominal computed tomography showed a pancreatic tumor with multiple liver metastases...
May 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29479514/combined-open-and-endoscopic-endonasal-skull-base-resection-of-a-rare-endometrial-carcinoma-metastasis
#14
Melissa M Stamates, John M Lee, Ryan T Merrell, Michael J Shinners, Ricky H Wong
In the absence of significant extracranial disease, patients with solitary brain metastases have shown benefit with resection. Brain lesions due to endometrial cancer are uncommon, and the only described skull base involvement is limited to the pituitary gland. We report the case of a 60-year-old female with endometrial cancer who presented with weeks of right cheek pain and numbness that was accompanied by headaches. We describe the magnetic resonance imaging (MRI) findings and surgical resection of a solitary endometrial metastasis involving the infratemporal fossa, middle fossa, cavernous sinus, trigeminal nerve, and nasal sinuses...
January 2018: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/29438788/cerebellar-peduncle-localized-oligodendroglioma-case-report-and-review-of-the-literature
#15
Oguz Baran, Omur Kasimcan, Hakan Oruckaptan
BACKGROUND: Oligodendrogliomas constitute 5% of all primary brain tumors and are the third most common cancer among intracranial tumors. More than 90% of oligodendrogliomas have supratentorial localization. Oligodendrogliomas arising in cerebellar peduncle are substantially rare, <1%. Up to now, 6 oligodendroglioma cases with cerebellar peduncle localization have been presented. We aimed to discuss our World Health Organization grade II oligodendroglioma case, which originated from cerebellar peduncle in the light of literature...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29421164/the-long-term-impact-of-neurofeedback-on-symptom-burden-and-interference-in-patients-with-chronic-chemotherapy-induced-neuropathy-analysis-of-a-randomized-controlled-trial
#16
Sarah Prinsloo, Diane Novy, Larry Driver, Randall Lyle, Lois Ramondetta, Cathy Eng, Gabriel Lopez, Yisheng Li, Lorenzo Cohen
CONTEXT: Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment and may adversely affect quality of life (QOL) for years. OBJECTIVES: We explored the long-term effects of electroencephalographic neurofeedback (NFB) as a treatment for CIPN and other aspects of QOL. METHODS: Seventy-one cancer survivors (mean age 62.5; 87% females) with CIPN were randomized to NFB or to a waitlist control (WLC) group. The NFB group underwent 20 sessions of NFB where rewards were given for voluntary changes in electroencephalography...
May 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29417143/accuracy-of-predictions-of-patients-with-breast-cancer-of-future-well-being-after-immediate-breast-reconstruction
#17
Clara Nan-Hi Lee, Michael Patrick Pignone, Allison M Deal, Lillian Blizard, Caprice Hunt, Ruth Huh, Yuen-Jong Liu, Peter Anthony Ubel
Importance: Making a good decision about breast reconstruction requires predicting how one would feel after the procedure, but people tend to overestimate the impact of events on future well-being. Objective: To assess how well patients predict future well-being after mastectomy, with or without immediate reconstruction, with the following a priori hypotheses: Patients will overestimate the negative impact of mastectomy and positive impact of reconstruction, and prediction accuracy will be associated with decision satisfaction and decision regret...
April 18, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29405021/-effect-of-oral-glutamine-on-chemotherapy-induced-peripheral-neuropathy-in-cancer-patients-an-evidence-based-appraisal
#18
Wan-Na Sun, Jing-Wei Su, Zih-Ping Shen, Hsin-Tien Hsu
BACKGROUND: Chemotherapy may induce peripheral neuropathy, which often results in the chemotherapy dose being reduced or the chemotherapy regimen being stopped. At present, there are no treatment guidelines for chemotherapy-induced peripheral neuropathy. Glutamine is one of the treatment strategies currently applied in practice. This strategy is expensive and lacks clear evidence as to its efficacy. PURPOSE: To evaluate the effect of oral glutamine on CIPN in cancer patients...
February 2018: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/29399185/il-8-is-upregulated-in-cervical-cancer-tissues-and-is-associated-with-the-proliferation-and-migration-of-hela-cervical-cancer-cells
#19
Linlin Jia, Fengying Li, Mingliang Shao, Wei Zhang, Chunbin Zhang, Xiaolian Zhao, Haiyan Luan, Yaling Qi, Pengxia Zhang, Lichun Liang, Xiuyue Jia, Kun Zhang, Yan Lu, Zhe Yang, Xiulin Zhu, Qi Zhang, Jiwei Du, Weiqun Wang
Interleukin-8 (IL-8) serves an important function in chronic inflammation and cancer development; however, the underlying molecular mechanism(s) of IL-8 in uterine cervical cancer remains unclear. The present study investigated whether IL-8 and its receptors [IL-8 receptor (IL-8R)A and IL-8RB] contributed to the proliferative and migratory abilities of HeLa cervical cancer cells, and also investigated the potential underlying molecular mechanisms. Results demonstrated that IL-8 and its receptors were detected in HeLa cells, and levels of IL-8RA were significantly increased compared with those of IL-8RB...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29390464/vascular-spinal-cord-obstruction-associated-with-superior-vena-cava-syndrome-a-case-report-and-literature-review
#20
REVIEW
Xiaoling Zhang, Xinyuan Li, Meihong Meng, Jie Cao, Xiaonan Song, Kangding Liu, Shaokuan Fang
RATIONALE: Superior vena cava syndrome (SVCS) is the obstruction of blood flow through the SVC, causing complete or partial blockade of the collateral circulation of returning venous blood. SVCS is frequently presented with facial, neck, trunk, and upper limbs swelling and so on. However, to the best of our knowledge, the obstruction of the venous return in the spinal veins is rarely a manifestation of SVCS. PATIENT CONCERNS: We presented a rare case of a 52-year-old male patient with 2-month history of progressive right upper limb numbness and swelling and 10-day history of extremities malfunctioning...
December 2017: Medicine (Baltimore)
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