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https://www.readbyqxmd.com/read/28431996/comparison-of-silodosin-monotherapy-versus-silodosin-with-tadalafil-add-on-therapy-in-patients-with-benign-prostatic-hyperplasia
#1
Takashi Yoshida, Hidefumi Kinoshita, Seiji Shimada, Makoto Taguchi, Tadashi Matsuda
OBJECTIVE: To evaluate the efficacy and safety of add-on therapy with the phosphodiesterase type 5 inhibitor tadalafil for patients with lower urinary tract symptoms secondary to benign prostatic hyperplasia (LUTS/BPH) treated with the α1-adrenoceptor blocker silodosin. METHODS: We analyzed 103 patients with LUTS/BPH with an International Prostate Symptom Score (IPSS) of >8 after ≥4 weeks of silodosin treatment from April 2016 through December 2016 at Kori Hospital...
April 18, 2017: Urology
https://www.readbyqxmd.com/read/28420444/case-report-acth-secreting-pituitary-carcinoma-metastatic-to-the-liver-in-a-patient-with-a-history-of-atypical-pituitary-adenoma-and-cushing-s-disease
#2
Amy S Joehlin-Price, Douglas A Hardesty, Christina A Arnold, Lawrence S Kirschner, Daniel M Prevedello, Norman L Lehman
BACKGROUND: Pituitary carcinoma is a rare entity requiring the presence of metastasis to confirm its malignant potential. We report a case of pituitary carcinoma and discuss the diagnosis and management of this lesion in relation to the existing literature. CASE PRESENTATION: The patient is a 51-year-old woman with Cushing's disease and intact adrenal glands who was diagnosed with metastatic pituitary carcinoma to the liver, 29 months after initial resection of an ACTH-secreting primary atypical pituitary adenoma (APA)...
April 18, 2017: Diagnostic Pathology
https://www.readbyqxmd.com/read/28409915/nitrogen-and-phosphorus-harvesting-from-human-urine-using-a-stripping-absorption-and-precipitation-process
#3
Surendra K Pradhan, Anna Mikola, Riku Vahala
Human urine contains significant amounts of N (nitrogen) and P (phosphorus); therefore it has been successfully used as fertilizer in different crops. But the use of urine as fertilizer has several constraints, such as, the high cost of transportation, an unpleasant smell, the risk of pathogens, and pharmaceutical residue. A combined and improved N stripping and P precipitation technique is used in this study. In this technique, Ca(OH)2 is used to increase the pH of urine which converts ammonium into ammonia gas and precipitate P as Ca-P compound...
April 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28407394/efficacy-and-safety-of-onabotulinumtoxina-injection-in-patients-with-refractory-overactive-bladder-first-multicentric-study-in-turkish-population
#4
Kadir Onem, Omer Bayrak, Abdullah Demirtas, Burhan Coskun, Murat Dincer, Izzet Kocak, Rahmi Onur
AIMS: To investigate the efficacy and safety of intradetrusor onabotulinumtoxinA (onaBoNT-A) injection in patients with overactive bladder (OAB) refractory to antimuscarinic treatment. METHODS: A total of 80 patients with OAB symptoms were enrolled in this prospective multicenter study and received 100 U intradetrusor onaBoNT-A injection.The changes from baseline in the frequency of voiding, urge urinary incontinence (UI) and urge episodes, mean and maximum bladder capacities, uroflowmetry, post-void residual urine volume (PVR), quality of life score, and treatment benefit scale score were assessed...
April 13, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28406701/prompt-rise-in-urinary-ammonium-excretion-suffices-to-mitigate-metabolic-acidosis-in-an-experimental-animal-model-of-severe-normovolemic-hemodilution
#5
J K Teloh, I N Waack, H de Groot
Recently, we have established a model of severe stepwise normovolemic hemodilution to a hematocrit of 10% in rats employing three different colloidal volume replacement solutions (Voluven, Volulyte and Gelafundin) that are routinely used in clinical practice at present. We did not see severe dilutional acidosis as to be expected, but a decline in urinary pH. We here looked on further mechanisms of renal acid excretion during normovolemic hemodilution. Bicarbonate, which had been removed during normovolemic hemodilution, was calculated with the help of the Henderson-Hasselbalch equation...
April 12, 2017: Physiological Research
https://www.readbyqxmd.com/read/28403592/comparison-of-transurethral-incision-of-the-prostate-and-silodosin-in-patients-having-benign-prostatic-obstruction-in-terms-of-retrograde-ejaculation
#6
Basri Cakiroglu, Aydin Ismet Hazar, Orhun Sinanoglu, Ersan Arda, Sinan Ekici
BACKGROUND: To compare the functional outcomes and retrograde ejaculation (RE) after transurethral incision of the prostate (TUIP) or silodosin in bladder outlet obstruction (BOO) secondary to a small prostate. METHODS: Prospectively collected data from December 2011 through December 2014 of 192 LUTS patients having fertility concerns with prostate volume smaller than 40 ml receiving either TUIP or silodosin treatment were prospectively reviewed. The treatment outcomes were evaluated and compared...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28398301/expression-of-autophagy-in-different-stages-of-neurogenic-bladder-after-spinal-cord-injury-in-rats
#7
F-S Zeng, L Zhang, B-J Cui, L-G Huang, Q Zhang, M Sun, B-L Liu, F Meng, Q Li, D-Q Wang, Q-S Sun
STUDY DESIGN: Experimental study. OBJECTIVES: To investigate the expression of autophagy in different stages of the neurogenic bladder after spinal cord injury (SCI) in rats. SETTING: Second Hospital of Shandong University, Jinan, China. METHODS: A total of 36 Wistar rats were divided into the SCI and control groups. In total, six animals were killed and sampled from each group at 1, 4 and 14 days after surgery of T10-T11 level...
April 11, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28394496/change-of-ultrasound-estimated-bladder-weight-and-bladder-wall-thickness-after-treatment-of-bladder-outlet-obstruction-with-dutasteride
#8
Ha Na Lee, Young-Suk Lee, Deok Hyun Han, Kyu-Sung Lee
OBJECTIVES: To investigate the change of bladder wall hypertrophy to relieve bladder outlet obstruction (BOO) by treatment with 5α-reductase inhibitor. METHODS: Men who have BOO confirmed by urodynamic study (BOO index ≥40) were treated with dutasteride 0.5 mg once a day for 6 months. We measured ultrasound estimated bladder weight (UEBW), UEBW divided by body surface area (UEBW/BSA), and bladder wall thickness (BWT) before and after treatment. Changes in LUTS parameters were assessed by using the International Prostate Symptom Score, uroflowmetry, residual urine volume, prostate volume, serum prostate-specific antigen (PSA), and LUTS outcome scores (LOS)...
May 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28390021/pharmaceuticals-and-illicit-drugs-in-wastewater-samples-in-north-eastern-tunisia
#9
Bilel Moslah, Evroula Hapeshi, Amel Jrad, Despo Fatta-Kassinos, Abderrazek Hedhili
Pharmaceutically active substances (PhACs) and drugs of abuse (DAs) are two classes of contaminants of emerging concern that have attracted great concern and interest by the scientific community during the last two decades. Numerous studies have revealed their presence in treated urban wastewaters. This is mainly due to the fact that some compounds are not efficiently removed during wastewater treatment processes, and are thus able to reach the aquatic environment through wastewater discharge and reuse practices...
April 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28386345/tgf-%C3%AE-mapk-signaling-mediates-the-effects-of-bone-marrow-mesenchymal-stem-cells-on-urinary-control-and-interstitial-cystitis-after-urinary-bladder-transplantation
#10
Ya Xiao, Ya-Jun Song, Bo Song, Chi-Bing Huang, Qing Ling, Xiao Yu
OBJECTIVE: This study aimed to explore the role of the transforming growth factor-β/mitogen activated protein kinase (TGF-β/MAPK) signaling pathway in the effects of bone marrow mesenchymal stem cells (BMSCs) on urinary control and interstitial cystitis in a rat model of urinary bladder transplantation. METHODS: A urinary bladder transplantation model was established using Sprague-Dawley rats. Rats were assigned to normal (blank control), negative control (phosphate-buffered saline injection), BMSCs (BMSC injection), sp600125 (MAPK inhibitor injection), or protamine sulfate (protamine sulfate injection) groups...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28380512/direct-and-correlated-responses-to-selection-in-two-lines-of-rabbits-selected-for-feed-efficiency-under-ad-libitum-and-restricted-feeding-iii-digestion-and-excretion-of-nitrogen-and-minerals
#11
T Gidenne, L Fortun-Lamothe, C Bannelier, C Molette, H Gilbert, M L Chemit, M Segura, F Benitez, F Richard, H Garreau, L Drouilhet
Two rabbit lines have been created to result in better feed efficiency: the ConsoResidual line was selected for a lower residual feed intake under ad libitum feeding, and the ADGrestrict line was selected for higher ADG under restricted feeding (-20% of ad libitum). The present study aimed to analyze the digestion and excretion of N and minerals from 29 to 63 d of age of these 2 lines compared with an unselected control line (G0) under 2 feeding levels (ad libitum or restricted). The ADGrestrict line had greater digestibility compared with G0 (+1...
March 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28374101/major-and-minor-complications-after-anterior-rectal-resection-for-deeply-infiltrating-endometriosis
#12
Stefan P Renner, Hermann Kessler, Nalan Topal, Kim Proske, Werner Adler, Stefanie Burghaus, Werner Haupt, Matthias W Beckmann, Johannes Lermann
PURPOSE: The aim of the present study was to analyze major and minor complications-including long-term impairment of intestinal, bladder, and sexual function-following surgery for deeply infiltrating endometriosis using anterior rectal resection. METHODS: Patients who had undergone anterior rectal resection due to endometriosis between 2001 and 2011 were included (n = 113). Clinical and surgical data, as well as minor and major complications, were recorded. A questionnaire was sent to the patients and also to a healthy control group (n = 100)...
April 3, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28373972/in-vivo-efficacy-and-pharmacokinetics-of-optimized-apidaecin-analogs
#13
Rico Schmidt, Daniel Knappe, Elisabeth Wende, Eszter Ostorházi, Ralf Hoffmann
Proline-rich antimicrobial peptides (PrAMPs) represent promising alternative therapeutic options for the treatment of multidrug-resistant bacterial infections. PrAMPs are predominantly active against Gram-negative bacteria by inhibiting protein expression via at least two different modes of action, i.e., blocking the ribosomal exit tunnel of 70S ribosomes (oncocin-type binding) or inhibiting the assembly of the 50S ribosomal subunit (apidaecin-type binding). The in vivo efficacy and favorable biodistribution of oncocins confirmed the therapeutic potential of short PrAMPs for the first time, whereas the in vivo evaluation of apidaecins is still limited despite the promising efficacy of apidaecin-analog Api88 in an intraperitoneal murine infection model...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/28372941/antineoplastic-drug-residues-inside-homes-of-chemotherapy-patients
#14
Antje Böhlandt, Yulia Sverdel, Rudolf Schierl
Chemotherapy treatment of cancer patients has shifted from inpatient to outpatient administration. Thus, family members are potentially exposed to cytotoxic drug residues from patients' excretions inside their homes. The study's aim was to evaluate the surface contamination and the potential uptake of antineoplastic drug residues by family members at home of chemotherapy patients. Overall, 265 wipe samples from 13 homes were taken at two times after chemotherapy from different surfaces (toilet, bathroom, kitchen)...
March 27, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28372163/abuse-of-anabolic-agents-in-beef-cattle-could-bile-be-a-possible-alternative-matrix
#15
Francesca Lega, Roberto Angeletti, Roberto Stella, Lorenzo Rigoni, Giancarlo Biancotto, Danilo Giusepponi, Simone Moretti, Giorgio Saluti, Roberta Galarini
European Union prohibited the use of anabolic agents in food producing animals since 1988. An efficient control of abuses is guaranteed not only by highly performing analytical methods, but also by knowledge of metabolic pathways, kinetics of elimination and tissue distribution. To obtain data concerning metabolites production and accumulation in bile, two typical growth promoting treatments are carried out in cattle. In the first study, sixteen beef cattle were implanted with trenbolone acetate and estradiol...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28370376/intravesical-prostatic-protrusion-can-predict-therapeutic-response-to-silodosin-in-male-patients-with-lower-urinary-tract-symptoms
#16
Yoshihisa Matsukawa, Shohei Ishida, Tsuyoshi Majima, Yasuhito Funahashi, Naoto Sassa, Masashi Kato, Yasushi Yoshino, Momokazu Gotoh
OBJECTIVES: To investigate the predicting factors of therapeutic response to α1-blockers in patients with lower urinary tract symptoms associated with benign prostate enlargement based on a urodynamic study. METHODS: This was a prospective study involving 125 outpatients with lower urinary tract symptoms associated with benign prostate enlargement. They received 8 mg of silodosin for 12 months. International Prostate Symptom Score, Overactive Bladder Symptom Score, International Prostate Symptom Score quality of life assessment, and urodynamic study were used to assess subjective and objective symptoms...
April 2, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28369090/rapid-mapping-of-urinary-schistosomiasis-an-appraisal-of-the-diagnostic-efficacy-of-some-questionnaire-based-indices-among-high-school-students-in-katsina-state-northwestern-nigeria
#17
Tolulope Ebenezer Atalabi, Taiwo Oluwakemi Adubi, Umar Lawal
BACKGROUND: In sub-Saharan Africa, over 200 million individuals are estimated to be infected with urinary and intestinal schistosomiasis. In a bid to lay a foundation for effective future control programme, this study was carried out with the aim of assessing the diagnostic efficacy of some questionnaire-based rapid assessment indices of urinary schistosomiasis. METHODOLOGY: A total number of 1,363 subjects were enrolled for the study. Questionnaires were administered basically in English and Hausa languages by trained personnel...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28368455/tracking-a-cad-alk-gene-rearrangement-in-urine-and-blood-of-a-colorectal-cancer-patient-treated-with-an-alk-inhibitor
#18
G Siravegna, A Sartore-Bianchi, B Mussolin, A Cassingena, A Amatu, L Novara, M Buscarino, G Corti, G Crisafulli, A Bartolini, F Tosi, M Erlander, F Di Nicolantonio, S Siena, A Bardelli
Background: Monitoring response and resistance to kinase inhibitors is essential to precision cancer medicine, and is usually investigated by molecular profiling of a tissue biopsy obtained at progression. However, tumor heterogeneity and tissue sampling bias limit the effectiveness of this strategy. In addition, tissue biopsies are not always feasible and are associated with risks due to the invasiveness of the procedure. To overcome these limitations, blood-based liquid biopsy analysis has proven effective to non-invasively follow tumor's clonal evolution...
March 24, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28366702/finding-nemo-nerve-sparing-midurethral-obstruction-a-pathophysiologically-accurate-model-of-rodent-partial-bladder-outlet-obstruction
#19
Martin Sidler, Karen Aitken, Janet Jiang, Dominika Bijos, Jaques Belik, Darius J Bägli
OBJECTIVE: To develop and evaluate a novel technique modeling partial bladder outlet obstruction (pBOO) using a Nerve-sparing Mid-urethral Obstruction (NeMO) approach. MATERIALS AND METHODS: Female unoperated rats were compared to rats after NeMO, NeMO-sham, proximal urethral obstruction (PU), or PU-sham. Residual volume, bladder capacity, voiding volume, and bladder mass were recorded; contractile characteristics of isolated bladder strips were also analyzed. Additionally, we quantitated nerve fibers at the bladder neck as well as extracellular matrix in the bladder wall...
March 30, 2017: Urology
https://www.readbyqxmd.com/read/28361519/evidence-is-enough-a-systematic-review-and-network-meta-analysis-of-the-efficacy-of-tamsulosin-0-2-mg-and-tamsulosin-0-4-mg-as-an-initial-therapeutic-dose-in-asian-benign-prostatic-hyperplasia-patients
#20
Su Jin Kim, In-Soo Shin, Sung-Jong Eun, Taeg-Keun Whangbo, Jin Wook Kim, Young Sam Cho, Joon Chul Kim
PURPOSE: We compared the efficacy of tamsulosin between 0.2 mg and 0.4 mg in Asian prostatic hyperplasia (BPH) patients using network meta-analysis due to lack of studies with direct comparison. METHODS: The literature search was conducted using the MEDLINE, Embase, and Cochrane Library. Keywords used were "BPH," "tamsulosin," "placebo." Experimental groups were defined as tamsulosin 0.2 mg (Tam 0.2) and 0.4 mg (Tam 0.4) and common control group was defined as placebo for indirect treatment comparison...
March 24, 2017: International Neurourology Journal
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