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https://www.readbyqxmd.com/read/28733235/determination-of-fumonisin-b1-levels-in-body-fluids-and-hair-from-piglets-fed-fumonisin-b1-contaminated-diets
#1
Pollyana C M C Souto, Alessandra V Jager, Fernando G Tonin, Tânia Petta, Mayra C Di Gregório, Anne-Marie Cossalter, Philippe Pinton, Isabelle P Oswald, George E Rottinghaus, Carlos A F Oliveira
The levels of fumonisin B1 (FB1) residues in plasma, urine, feces and hair from 24 piglets fed FB1-contaminated diets containing 3.1, 6.1 or 9.0 μg FB1.g(-1) for 28 days were determined using liquid chromatography coupled to mass spectrometry (LC-MS/MS). The levels of FB1 in plasma, urine, feces and pooled hair (n = 3) samples varied from 0.15-1.08 μg.L(-1), 16.09-75.01 μg.L(-1), 1.87-13.89 μg.g(-1) and 2.08-8.09 ng.g(-1), respectively. Significant correlations (r = 0.808-0.885; P < 0.001; N = 18) were found between FB1 intake and plasma FB1 on days 7, 14, 21 and 28...
July 18, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28728829/short-term-double-natural-orifice-catheterization-nonoperative-management-of-hydrocolpos-in-persistent-cloaca-patients-case-series
#2
Stjepan Višnjić, Mislav Bastić, Mateja Marčec, Marko Mesić
PURPOSE: Management of hydrocolpos in cloaca patients is of clinical importance. We report a nonoperative method for the management of hydrocolpos in the form of initial catheter decompression, followed by an endoscopy with catheters placement into both the bladder and vagina, and leaving these catheters for 9 and 14days respectively. METHODS: The medical records of six cloaca patients with hydrocolpos in the last 12years were reviewed. The outcomes measured were the renal function, bladder emptying, the presence/resolution of hydronephrosis, and the recurrence of hydrocolpos...
June 27, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28727385/abobotulinum-a-toxin-injection-in-patients-with-refractory-idiopathic-detrusor-overactivity-injections-in-detrusor-trigone-and-bladder-neck-or-prostatic-urethra-versus-detrusor-only-injections
#3
Maryam Emami, Pejman Shadpour, Amir H Kashi, Masoud Choopani, Mohammadreza Zeighami
PURPOSE: To evaluate if the injections of abobotulinum-A toxin in trigone and bladder neck/prostatic urethra in addition to detrusor provides better symptoms relief and urodynamic findings in patients with idiopathic detrusor overactivity (IDO) refractory to medical treatment. MATERIALS AND METHODS: A total of 74 patients with IDO refractory to anticholinergics received injections in detrusor, trigone and bladder neck/prostatic urethra (Group A, N=36) versus detrusor only injections (Group B, N=38) of abobotulinum-A toxin...
July 20, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28723770/initial-application-of-transanal-endoscopic-microsurgery-for-high-risk-lower-rectal-gastrointestinal-stromal-tumor-after-imatinib-mesylate-neoadjuvant-chemotherapy-a-case-report
#4
Qiaofei Liu, Guangxi Zhong, Weixun Zhou, Guole Lin
RATIONALE: The lower rectal gastrointestinal stromal tumor (GIST) is a rare entity and warrants special attentions because of the considerations of preserving of anal and urinal functions. Neoadjuvant therapy with imatinib mesylate (IM) has achieved great success in GIST, which potentially extends the applications of function-preserving minimally invasive surgical procedures. Transanal endoscopic microsurgery (TEM) is a well-developed minimally invasive technique for benign tumors in lower rectum...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28723374/urodynamics-before-surgery-for-stress-urinary-incontinence
#5
Suneetha Rachaneni, Pallavi Latthe
Following three noninferiority randomised controlled trials from different countries showing exactly the same results, it is time to translate this evidence into practice. In women undergoing primary surgery for pure stress urinary incontinence or stress-predominant mixed urinary incontinence without voiding difficulties, careful office evaluation including uroflowmetry and postvoid residual urine can replace invasive investigations such as cystometry, saving patients from embarrassment and a risk of urinary infection...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723368/definition-of-success-after-surgery-for-female-stress-incontinence-or-voiding-dysfunction-an-attempt-at-standardization
#6
REVIEW
Maude E Carmel, Donna Y Deng, Tamsin J Greenwell, Philippe E Zimmern
CONTEXT: There is currently no standardized definition of success for surgery for stress urinary incontinence (SUI) and voiding dysfunction (VD) in women. OBJECTIVE: To review the use of outcome measures (OMs) and definitions of success in the literature on SUI and VD surgery in women in an attempt to provide recommendations for future publications. EVIDENCE ACQUISITION: A PubMed search of all English language full-text articles on SUI and VD surgery in women published between 2010 and 2015 was performed...
August 2016: European Urology Focus
https://www.readbyqxmd.com/read/28721281/safety-and-efficacy-of-tamsulosin-alfuzosin-or-silodosin-as-monotherapy-for-luts-in-bph-a-double-blind-randomized-trial
#7
Chikka Moga Siddaiah Manohar, Mahadevappa Nagabhushana, Vilvapathy Senguttuvan Karthikeyan, Ramachandra Pudakalkatti Sanjay, Ananth Janardhan Kamath, Ramaiah Keshavamurthy
INTRODUCTION: Currently alpha1-adrenoceptor blockers (AB) are widely used as first-line therapy to improve lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). We compared the efficacy and safety profile of tamsulosin, alfuzosin and silodosin in LUTS due to BPH. MATERIAL AND METHODS: Consecutive consenting male patients (N = 269) undergoing medical management of BPH with AB from February 2012 to October 2015 were enrolled. Patients were randomized to a 0...
June 30, 2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/28717543/outcome-analysis-of-transurethral-resection-versus-potassium-titanyl-phosphate-photo-selective-vaporization-of-the-prostate-for-the-treatment-of-benign-prostatic-hyperplasia-a-randomized-controlled-trial-with-4-years-follow-up
#8
Bimalesh Purkait, Rahul Janak Sinha, Krishna Swamy A Srinivas, Ankur Bansal, Ashok Kumar Sokhal, Vishwajeet Singh
OBJECTIVE: Photovaporization of prostate (PVP) is a newer surgical modality of benign prostatic hyperplasia (BPH) which is gaining importance recently. There are a few randomized controlled trials that showed safety and efficacy of PVP in comparison with transurethral resection of prostate (TURP) with limited follow-up period (<2 years). Here, we are presenting a comparative study performed on potassium titanyl phosphate (KTP) PVP laser versus TURP for the treatment of BPH with long-term follow-up period...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28715674/the-presence-of-licit-and-illicit-drugs-in-police-stations-and-their-implications-for-workplace-drug-testing
#9
Gregory S Doran, Ralph Deans, Carlo De Filippis, Chris Kostakis, Julia A Howitt
The presence of licit and illicit drug residues on surfaces was studied in 10 police stations and a central drug evidence store in New South Wales, Australia, with the results compared to similar surfaces in four public buildings (to establish a community baseline). The results of almost 850 workplace surface swabs were also compared to the outcome of drug analysis in urine and hair samples volunteered by police officers. Surfaces were swabbed with alcohol and the swabs were extracted and analysed by LC-MS/MS...
July 5, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28714271/influence-of-residual-renal-function-in-carotid-modeling-as-a-marker-of-early-atherosclerosis-in-dialysis-patients
#10
Merita Rroji, Nereida Spahia, Saimir Seferi, Myftar Barbullushi, Goce Spasovski
Atherosclerosis is frequently present in patients with chronic kidney disease (CKD) treated with dialysis. We evaluated the association between residual renal function (RRF), phosphate level, inflammation and other risk factors in carotid modeling as a marker of early atherosclerosis in peritoneal dialysis (PD) compared with hemodialysis (HD) patients. We studied 39 stable PD and 53 HD patients on renal replacement therapy (RRT) for 3 to 36 months duration. B-mode ultrasonography was used to determine carotid artery intima media thickness (CIMT)...
July 17, 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/28712168/justification-for-re-look-cystoscopy-after-posterior-urethral-valve-fulguration
#11
Gul Nawaz, Ijaz Hussain, Shujah Muhammad, Muhammad Imran Jamil, Asad Ur Rehman, Nadeem Iqbal, Saeed Akhter
BACKGROUND: Posterior urethral valve (PUV) is life-threatening congenital anomaly of the urinary tract that results in vesicoureteric reflux, recurrent UTI, voiding dysfunction and renal insufficiency if not treat timely. Endoscopic ablation of posterior urethral valves using cold knife or laser is the current gold standard therapy. Many urologists go for repeat cystoscopy to see residual valve or stricture while others repeat VCUG to measure the posterior to anterior urethral ratio for residual obstruction...
January 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28710888/chronic-spinal-cord-injury-causes-up-regulation-of-serotonin-5-ht-2a-and-2c-receptors-in-lumbosacral-cord-motoneurons
#12
Nailong Cao, Jianshu Ni, Xiaohu Wang, Hongjian Tu, Baojun Gu, Jiemin Si, Gang Wu, Karl-Erik Andersson
OBJECTIVES: To explore if the mechanism of the voiding dysfunction caused by spinal cord injury in rats can be improved by intravenous administration of the 5-HT2A/2C receptor agonist, DOI, and discuss whether it can be ascribed to serotonin 2A and 2C receptor up-regulation in lumbosacral cord motoneurons. MATERIALS AND METHODS: Female Sprague-Dawley rats were used, which were divided into two groups (Spinal cord injury group VS Normal control group). Under urethane anesthesia, cystometry was performed to examine the variation of urodynamic parameters before and after successive intrathecal administration of various doses of DOI into the lumbosacral cord...
July 15, 2017: BJU International
https://www.readbyqxmd.com/read/28710553/metabolism-and-distribution-of-pharmacological-homoarginine-in-plasma-and-main-organs-of-the-anesthetized-rat
#13
Duygu Naile Günes, Arslan Arinc Kayacelebi, Erik Hanff, Joel Lundgren, Björn Redfors, Dimitrios Tsikas
L-Homoarginine (hArg) and guanidinoacetate (GAA) are produced from L-arginine (Arg) by the catalytic action of arginine:glycine amidinotransferase. Guanidinoacetate methyltransferase methylates GAA on its non-guanidine N atom to produce creatine. Arg and hArg are converted by nitric oxide synthase (NOS) to nitric oxide (NO). NO is oxidized to nitrite and nitrate which circulate in the blood and are excreted in the urine. Asymmetric dimethylarginine (ADMA), an NOS inhibitor, is widely accepted to be exclusively produced after asymmetric N (G)-methylation of Arg residues in proteins and their regular proteolysis...
July 14, 2017: Amino Acids
https://www.readbyqxmd.com/read/28708591/an-improved-nerve-sparing-radical-hysterectomy-technique-for-cervical-cancer-using-the-paravesico-vaginal-space-as-a-new-surgical-landmark
#14
Yuqin Zhang, Tingyan Shi, Sheng Yin, Sining Ma, Di Shi, Jun Guan, Libing Xiang, Yang Liu, Yulan Ren, Deyan Tan, Rongyu Zang
Bladder dysfunction remains a major postoperative challenge for early stage cervical cancer patients. The present prospective phase 2 trial in patients with stage IB1 and IIA1 cervical cancer follows up on our previous, unpublished work describing a new surgical landmark, the paravesico-vaginal space. We describe a novel nerve-sparing radical hysterectomy (NSRH) approach to treat early stage cervical cancer without compromising local control rate or survival. Between September 2015 and August 2016, 49 patients were enrolled to receive NSRH...
July 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28708202/experience-after-12-cases-with-the-adjustable-transobturator-male-sling-for-postprostatectomy-stress-urinary-incontinence
#15
Andrea Vismara Fugini, Luca Giovanessi, Michelangelo Tosana
OBJECTIVES: The aim of the study was the prospective evaluation of the efficacy of the adjustable transobturator male system (ArgusT®) for the treatment of postprostatectomy stress urinary incontinence (PPI). METHODS: Twelve consecutive patients were treated with ArgusT system for PPI. All patients were comprehensively evaluated preoperatively and after 3 and 6 months regarding daily pad use, residual urine, Incontinence Quality of Life Scale (I-QoL) score and International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) score...
July 1, 2017: Urologia
https://www.readbyqxmd.com/read/28704753/resveratrol-improves-prostate-fibrosis-during-progression-of-urinary-dysfunction-in-chronic-prostatitis
#16
Yi He, Hui-Zhi Zeng, Yang Yu, Jia-Shu Zhang, Xingping Duan, Xiao-Na Zeng, Feng-Tao Gong, Qi Liu, Bo Yang
AIM: We investigated whether prostate fibrosis was associated with urinary dysfunction in chronic prostatitis (CP) and whether resveratrol improved urinary dysfunction and the underlying molecular mechanism. METHODS: Rat model of CP was established via subcutaneous injections of DPT vaccine and subsequently treated with resveratrol. Bladder pressure and volume tests investigated the effect of resveratrol on urinary dysfunction in CP rats. Western blotting and immunohistochemical staining examined the expression level of C-kit/SCF and TGF-β/Wnt/β-catenin...
July 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28684085/incomplete-biomarker-response-in-mucopolysaccharidosis-type-i-after-successful-hematopoietic-cell-transplantation
#17
Gé-Ann Kuiper, Peter M van Hasselt, Jaap Jan Boelens, Frits A Wijburg, Eveline J Langereis
BACKGROUND: Residual disease, primarily involving musculoskeletal tissue, is a common problem in patients with neuronopathic mucopolysaccharidosis type I (MPS I, Hurler or severe Hurler-Scheie phenotype) after a successful hematopoietic cell transplantation (HCT). The concentration of the GAG derived biomarkers heparan sulfate (HS) and dermatan sulfate (DS), may reflect residual disease and is used for monitoring biochemical response to therapies. This study investigates the response of HS and DS in blood and urine to HCT in MPS I patients...
May 18, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28683471/non-invasive-prediction-of-recurrence-in-bladder-cancer-by-detecting-somatic-tert-promoter-mutations-in-urine
#18
Françoise Descotes, Norelyakin Kara, Myriam Decaussin-Petrucci, Eric Piaton, Florence Geiguer, Claire Rodriguez-Lafrasse, Jean E Terrier, Jonathan Lopez, Alain Ruffion
BACKGROUND: Urothelial bladder cancer (UBC) is characterised by a high risk of recurrence. Patient monitoring is currently based on iterative cystoscopy and on urine cytology with low sensitivity in non-muscle-invasive bladder cancer (NMIBC). Telomerase reverse transcriptase (TERT) is frequently reactivated in UBC by promoter mutations. METHODS: We studied whether detection of TERT mutation in urine could be a predictor of UBC recurrence and compared this to cytology/cystoscopy for patient follow-up...
July 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28673059/assessing-the-readjustable-sling-procedure-remeex-system-for-female-stress-urinary-incontinence-with-detrusor-underactivity
#19
Kwang Jin Ko, Yoon Seok Suh, Hyun Hwan Sung, Gyu Ha Ryu, Munjae Lee, Kyu-Sung Lee
PURPOSE: Many surgeons worry about postoperative voiding problems in patients with stress urinary incontinence (SUI) and detrusor underactivity (DU). This study hypothesized that adjusting the tension after surgery would benefit patients with DU, and therefore researchers evaluated the outcomes and quality of life of women with SUI and DU who underwent the readjustable sling procedure (Remeex). METHODS: The medical records of 27 patients who were treated with the Remeex system for SUI and DU between 2007 and 2013 were retrospectively analyzed...
June 2017: International Neurourology Journal
https://www.readbyqxmd.com/read/28672971/effect-of-%C3%AE-receptor-blockers-on-lower-urinary-tract-symptoms-sexual-function-and-quality-of-life-in-young-and-middle-aged-men-with-benign-prostatic-hyperplasia
#20
Tongqing Wang, Lei Wang, Yalin Liang, Jiechang Ju, Yi Cai, Jie Zhang, Hongtao Zhen, Yaolei Liu, Xiaolong Tang, Jizheng Wang, Jian Liu
The purpose of the present study was to compare the effectiveness of two common α1-receptor blockers, alfuzosin and tamsulosin, on lower urinary tract symptoms, sexual function, and quality of life in young and middle-aged people with benign prostatic hyperplasia. We recruited 80 young and middle-aged patients with benign prostatic hyperplasia and divided them into two groups that received either the non-selective α1-receptor blocker alfuzosin or the selective α1A-receptor blocker tamsulosin for 18 consecutive days...
July 2017: Experimental and Therapeutic Medicine
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