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torsade de pointes

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https://www.readbyqxmd.com/read/29759840/twisting-and-turning-to-find-an-explanation-for-torsades-de-pointes
#1
EDITORIAL
Sachin Nayyar, Andreu Porta-Sánchez, Kumaraswamy Nanthakumar
No abstract text is available yet for this article.
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29759839/short-lasting-episodes-of-torsade-de-pointes-in-the-chronic-atrioventricular-block-dog-model-have-a-focal-mechanism-while-longer-lasting-episodes-are-maintained-by-re-entry
#2
Nele Vandersickel, Alexandre Bossu, Jan De Neve, Albert Dunnink, Veronique M F Meijborg, Marcel A G van der Heyden, Jet D M Beekman, Jacques M T De Bakker, Marc A Vos, Alexander V Panfilov
OBJECTIVES: This study investigated the arrhythmogenic mechanisms responsible for torsade de pointes (TdP) in the chronic atrioventricular block dog model, known for its high susceptibility for TdP. BACKGROUND: The mechanism of TdP arrhythmias has been under debate for many years. Focal activity as well as re-entry have both been mentioned in the initiation and the perpetuation of TdP. METHODS: In 5 TdP-sensitive chronic atrioventricular block dogs, 56 needle electrodes were evenly distributed transmurally to record 240 unipolar local electrograms simultaneously...
December 26, 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29754959/human-induced-pluripotent-stem-cell-derived-cardiac-cell-sheets-expressing-genetically-encoded-voltage-indicator-for-pharmacological-and-arrhythmia-studies
#3
Naim Shaheen, Assad Shiti, Irit Huber, Rami Shinnawi, Gil Arbel, Amira Gepstein, Noga Setter, Idit Goldfracht, Amit Gruber, Snizhanna V Chorna, Lior Gepstein
Fulfilling the potential of human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes for studying conduction and arrhythmogenesis requires development of multicellular models and methods for long-term repeated tissue phenotyping. We generated confluent hiPSC-derived cardiac cell sheets (hiPSC-CCSs), expressing the genetically encoded voltage indicator ArcLight. ArcLight-based optical mapping allowed generation of activation and action-potential duration (APD) maps, which were validated by mapping the same hiPSC-CCSs with the voltage-sensitive dye, Di-4-ANBDQBS...
May 7, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29753687/istaroxime-a-positive-inotropic-agent-devoid-of-proarrhythmic-properties-in-sensitive-chronic-atrioventricular-block-dogs
#4
Alexandre Bossu, Amée Kostense, Henriette D M Beekman, Marien J C Houtman, Marcel A G van der Heyden, Marc A Vos
Current inotropic agents in heart failure therapy associate with low benefit and significant adverse effects, including ventricular arrhythmias. Istaroxime, a novel Na+ /K+ -transporting ATPase inhibitor, also stimulates SERCA2a activity, which would confer improved inotropic and lusitropic properties with less proarrhythmic effects. We investigated hemodynamic, electrophysiological and potential proarrhythmic and antiarrhythmic effects of istaroxime in control and chronic atrioventricular block (CAVB) dogs sensitive to drug-induced Torsades de Pointes arrhythmias (TdP)...
May 10, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29738372/paradoxical-effects-of-sodium-calcium-exchanger-inhibition-on-torsade-de-pointes-and-early-afterdepolarization-in-a-heart-failure-rabbit-model
#5
Po-Cheng Chang, Yu-Ying Lu, Hui-Ling Lee, Shien-Fong Lin, Yen Chu, Ming-Shien Wen, Chung-Chuan Chou
Calcium homeostasis plays an important role in development of early afterdepolarizations (EADs) and torsade de pointes (TdP). The role of sodium-calcium exchanger (NCX) inhibition in genesis secondary Ca rise and EADs-TdP is still debated. Dual voltage and intracellular Ca optical mapping were conducted in 6 control and 9 failing rabbit hearts. After baseline electrophysiological and optical mapping studies, E4031 was given to simulate long QT syndrome. ORM-10103 was then administrated to examine the electrophysiological effects on EAD-TdP development...
May 3, 2018: Journal of Cardiovascular Pharmacology
https://www.readbyqxmd.com/read/29731714/proton-pump-inhibitors-and-serum-magnesium-levels-in-patients-with-torsades-de-pointes
#6
Pietro E Lazzerini, Iacopo Bertolozzi, Francesco Finizola, Maurizio Acampa, Mariarita Natale, Francesca Vanni, Rosella Fulceri, Alessandra Gamberucci, Marco Rossi, Beatrice Giabbani, Michele Caselli, Ilaria Lamberti, Gabriele Cevenini, Franco Laghi-Pasini, Pier L Capecchi
Background: Torsades de pointes (TdP) is a life-threatening ventricular tachycardia occurring in long QT-syndrome patients. It usually develops when multiple QT-prolonging factors are concomitantly present, more frequently drugs and electrolyte imbalances. Since proton-pump inhibitors (PPIs)-associated hypomagnesemia is an increasingly recognized adverse event, PPIs were recently included in the list of drugs with conditional risk of TdP, despite only few cases of TdP in PPI users have been reported so far...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29720397/increased-long-qt-and-torsade-de-pointes-reporting-on-tamoxifen-compared-with-aromatase-inhibitors
#7
Virginie Grouthier, Benedicte Lebrun-Vignes, Andrew M Glazer, Philippe Touraine, Christian Funck-Brentano, Antoine Pariente, Carine Courtillot, Anne Bachelot, Dan M Roden, Javid J Moslehi, Joe-Elie Salem
OBJECTIVE: A prolonged QTc (LQT) is a surrogate for the risk of torsade de pointes (TdP). QTc interval duration is influenced by sex hormones: oestradiol prolongs and testosterone shortens QTc. Drugs used in the treatment of breast cancer have divergent effects on hormonal status. METHODS: We performed a disproportionality analysis using the European database of suspected adverse drug reaction (ADR) reports to evaluate the reporting OR (ROR χ2 ) of LQT, TdP and ventricular arrhythmias associated with selective oestrogen receptor modulators (SERMs: tamoxifen and toremifene) as opposed to aromatase inhibitors (AIs: anastrozole, exemestane and letrozole)...
May 2, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29713819/evaluation-of-the-risk-factors-for-ventricular-arrhythmias-secondary-to-qt-prolongation-induced-by-papaverine-injection-during-coronary-flow-reserve-studies-using-a-4-fr-angio-catheter
#8
Yoshitaka Okabe, Kanichi Otowa, Yasuhito Mitamura, Hisayoshi Murai, Soichiro Usui, Shuichi Kaneko, Masayuki Takamura
Estimation of the fractional flow reserve (FFR) is considered to be an established method by which to assess stable coronary artery stenosis. Induction of maximal coronary hyperemia is important during the FFR procedure. Papaverine has been reported to increase the risk of ventricular arrhythmia (VA). The purpose of the present study was to discover predictors of papaverine-induced VAs developing during FFR measurement. A total of 213 clinically stable patients were included in the study. FFRs were determined after intracoronary papaverine administration (12 mg into the left and 8 mg into the right coronary arteries)...
April 30, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29698683/anticancer-drug-induced-cardiac-rhythm-disorders-current-knowledge-and-basic-underlying-mechanisms
#9
REVIEW
Joachim Alexandre, Javid Moslehi, Kevin R Bersell, Christian Funck-Brentano, Dan M Roden, Joe-Elie Salem
Significant advances in cancer treatment have resulted in decreased cancer related mortality for many malignancies with some cancer types now considered chronic diseases. Despite these improvements, there is increasing recognition that many cancer patients or cancer survivors can develop cardiovascular diseases, either due to the cancer itself or as a result of anticancer therapy. Much attention has focused on heart failure; however, other cardiotoxicities, notably cardiac rhythm disorders, can occur without underlying cardiomyopathy...
April 24, 2018: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29673905/-cardiovascular-adverse-effects-of-antimuscarinics-used-in-the-treatment-of-overactive-bladder-in-the-elderly-a-review
#10
C Chesnel, A Charlanes, C Hentzen, N Turmel, X Biardeau, C Brochard, S Campagne, G Capon, X Deffieux, B Fatton, X Gamé, R Haddad, C Jeandel, J Kerdraon, P Manceau, P Mares, M Mezzadri, P Mongiat-Artus, A-C Petit, B Peyronnet, J-M Soler, C Thuillier, J-M Vetel, G Robain, G Amarenco
AIM: The aim of this study was to review the evidence regarding the cardiovascular effects of urinary anticholinergic drugs in the elderly. METHODS: A literature review was conducted in October 2017 using the Medline/Pubmed database limiting the search to works in English or French. RESULTS: In total, 602 articles between March 1964 and October 2017 have been reported, 60 studies were analyzed, 19 were prospective trials. Geriatric population has a high prevalence of cardiovascular diseases (24...
April 16, 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29672845/drug-induced-proarrhythmia-and-torsade-de-pointes-a-primer-for-students-and-practitioners-of-medicine-and-pharmacy
#11
REVIEW
J Rick Turner, Ignacio Rodriguez, Emily Mantovani, Gary Gintant, Peter R Kowey, Ralph J Klotzbaugh, Krishna Prasad, Philip T Sager, Norman Stockbridge, Colette Strnadova
Multiple marketing withdrawals due to proarrhythmic concerns occurred in the United States, Canada, and the United Kingdom in the late 1980s to early 2000s. This primer reviews the clinical implications of a drug's identified proarrhythmic liability, the issues associated with these safety-related withdrawals, and the actions taken by the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) and by regulatory agencies in terms of changing drug development practices and introducing new nonclinical and clinical tests to asses proarrhythmic liability...
April 19, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29663322/quantitatively-characterizing-drug-induced-arrhythmic-contractile-motions-of-human-stem-cell-derived-cardiomyocytes
#12
Plansky Hoang, Nathaniel Huebsch, Shin Hyuk Bang, Brian A Siemons, Bruce R Conklin, Kevin E Healy, Zhen Ma, Sabir Jacquir
Quantification of abnormal contractile motions of cardiac tissue has been a noteworthy challenge and significant limitation in assessing and classifying the drug-induced arrhythmias (i.e. Torsades de pointes). To overcome these challenges, researchers have taken advantage of computational image processing tools to measure contractile motion from cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs). However, the amplitude and frequency analysis of contractile motion waveforms doesn't produce sufficient information to objectively classify the degree of variations between two or more sets of cardiac contractile motions...
April 16, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29651218/hypocalcemia-presenting-as-life-threatening-torsades-de-pointes-with-prolongation-of-qtc-interval
#13
Shibba Takkar Chhabra, Shivani Mehta, Sandeep Chhabra, Manikant Singla, Naved Aslam, Bishav Mohan, Gurpreet Singh Wander
Torsades de pointes with prolonged QTc interval is a form of ventricular tachycardia. Many predisposing factors have been identified and hypocalcemia is among the rare ones. Our case illustrates that though rare, hypocalcemia might manifest as torsades de pointes with prolongation of QTc interval. Early diagnosis and management of dyselectrolytemia can prevent these patients from catastrophic torsades de pointes.
April 2018: Indian Journal of Clinical Biochemistry: IJCB
https://www.readbyqxmd.com/read/29644628/quantitatively-characterizing-drug-induced-arrhythmic-contractile-motions-of-human-stem-cell-derived-cardiomyocytes
#14
Plansky Hoang, Nathaniel Huebsch, Shin Hyuk Bang, Brian A Siemons, Bruce R Conklin, Kevin E Healy, Zhen Ma, Sabir Jacquir
Quantification of abnormal contractile motions of cardiac tissue has been a noteworthy challenge and significant limitation in assessing and classifying the drug-induced arrhythmias (i.e. Torsades de pointes). To overcome these challenges, researchers have taken advantage of computational image processing tools to measure contractile motion from cardiomyocytes derived from human induced pluripotent stem cells (hiPSC-CMs). However, the amplitude and frequency analysis of contractile motion waveforms doesn't produce sufficient information to objectively classify the degree of variations between two or more sets of cardiac contractile motions...
April 12, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29644223/torsade-de-pointes-and-systemic-azole-antifungal-agents-analysis-of-global-spontaneous-safety-reports
#15
REVIEW
M Salem, T Reichlin, D Fasel, A Leuppi-Taegtmeyer
Background: Literature about torsade de pointes induced by azole antifungal agents is scarce, despite the well-known association. Furthermore, little is known about the latency time between commencing an azole antifungal agent and developing torsade de pointes. The objectives of the present study were therefore to identify all cases of torsade de pointes associated with systemic azole antifungal use reported to the WHO monitoring centre (Uppsala, Sweden) and to determine the latency times between commencing the azole and developing torsade de pointes...
June 30, 2017: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29643708/evidence-based-review-and-appraisal-of-the-use-of-droperidol-in-the-emergency-department
#16
REVIEW
Pei-Chun Lai, Yen-Ta Huang
Droperidol is a short-acting, potent dopamine D2 antagonist that can pass through the blood-brain barrier. A black box warning was issued for droperidol by the United States Food and Drug Administration in 2001 because of a risk of development of torsades de pointes induced by QT prolongation. Many experts feel that the incidence of arrhythmia is overestimated, and low-dose droperidol is almost always used by anesthesiologists for postoperative nausea and vomiting. In this review, we used evidence-based analysis to appraise high-quality studies with a low risk of bias published after 2001 on the use of droperidol in the emergency department (ED)...
January 2018: Ci Ji Yi Xue za Zhi, Tzu-chi Medical Journal
https://www.readbyqxmd.com/read/29621539/molecular-determinants-of-kv7-1-kcne1-channel-inhibition-by-amitriptyline
#17
Kathya Villatoro-Gómez, David O Pacheco-Rojas, Eloy G Moreno-Galindo, Ricardo A Navarro-Polanco, Martin Tristani-Firouzi, Dimitris Gazgalis, Meng Cui, José A Sánchez-Chapula, Tania Ferrer
Amitriptyline (AMIT) is a compound widely prescribed for psychiatric and non- psychiatric conditions including depression, migraine, chronic pain, and anorexia. However, AMIT has been associated with risks of cardiac arrhythmia and sudden death since it can induce prolongation of the QT interval on the surface electrocardiogram and torsade de pointes ventricular arrhythmia. These complications have been attributed to the inhibition of the rapid delayed rectifier potassium current (IKr ). The slow delayed rectifier potassium current (IKs ) is the main repolarizing cardiac current when IKr is compromised and it has an important role in cardiac repolarization at fast heart rates induced by an elevated sympathetic tone...
April 2, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29609088/milrinone-associated-cardiomyopathy-and-arrhythmia-in-cerebral-vasospasm
#18
Eva M Wu, Tarek Y El Ahmadieh, Benjamin Kafka, Matthew T Davies, Salah G Aoun, Jonathan A White
BACKGROUND: Milrinone is an inotropic and vasodilatory drug proven safe for use in the treatment of cerebral vasospasm. Despite its reported safety profile, its use is not free of side effects. Milrinone-associated cardiomyopathy and arrhythmia can occur in patients with cerebral vasospasm. CASE DESCRIPTION: This is a retrospective chart review of a patient who presented with aneurysmal subarachnoid hemorrhage and developed clinical vasospasm twice over a period of two weeks...
March 30, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29605013/dofetilide-dose-reductions-and-discontinuations-in-women-compared-with-men
#19
Sean D Pokorney, Debbie C Yen, Kristen B Campbell, Nancy M Allen LaPointe, Shubin Sheng, Laine Thomas, Tristram D Bahnson, James P Daubert, Jonathan P Picini, Kevin P Jackson, Kevin L Thomas, Sana M Al-Khatib
BACKGROUND: Compared with men, women have longer corrected QT (QTc) intervals, lower clearance of dofetilide, and higher rates of drug-induced torsades de pointes, but the dofetilide dosing algorithm is the same for men and women. OBJECTIVE: The purpose of this study was to evaluate the tolerability of the 500 μg twice daily dose of dofetilide for men and women. METHODS: Men and women admitted to Duke University Medical Center (January 1, 2006, to October 19, 2012) for the initiation of dofetilide 500 μg twice daily were matched 1:1 on age and estimated creatinine clearance...
April 2018: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29582428/selective-late-sodium-current-inhibitor-gs-458967-suppresses-torsades-de-pointes-by-mostly-affecting-perpetuation-but-not-initiation-of-the-arrhythmia
#20
Alexandre Bossu, Marien J C Houtman, Veronique M F Meijborg, Rosanne Varkevisser, Henriette D M Beekman, Albert Dunnink, Jacques M T de Bakker, Nevena Mollova, Sridharan Rajamani, Luiz Belardinelli, Marcel A G van der Heyden, Marc A Vos
BACKGROUND AND PURPOSE: Enhanced late sodium current (late INa ) in heart failure and long QT syndrome type 3 is proarrhythmic. GS-458967 (GS967) is a selective and potent late INa inhibitor. This study aimed to evaluate the antiarrhythmic effect of late INa inhibition by GS967 in the chronic atrioventricular block (CAVB) dog model sensitive to Torsade de Pointes arrhythmias (TdP) and to elucidate its electrophysiological mode of action in vivo and in vitro. METHODS - RESULTS: GS967 (IC50 for late INa ~ 200 nM) markedly shortened action potential duration of canine ventricular cardiomyocytes and repolarization parameters in vivo in sinus rhythm (SR, n=10) dogs, in a concentration-dependent manner...
March 27, 2018: British Journal of Pharmacology
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