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"ssti" OR "cutaneous abscess" OR "skin abscess"

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https://www.readbyqxmd.com/read/29026866/a-prospective-observational-study-of-the-epidemiology-management-and-outcomes-of-skin-and-soft-tissue-infections-due-to-carbapenem-resistant-enterobacteriaceae
#1
Oryan Henig, Eric Cober, Sandra S Richter, Federico Perez, Robert A Salata, Robert C Kalayjian, Richard R Watkins, Steve Marshall, Susan D Rudin, T Nicholas Domitrovic, Andrea M Hujer, Kristine M Hujer, Yohei Doi, Scott Evans, Vance G Fowler, Robert A Bonomo, David van Duin, Keith S Kaye
BACKGROUND: This study was performed to characterize the epidemiology, management, and outcomes of skin and soft tissue infection (SSTI) and colonization due to carbapenem-resistant Enterobacteriaceae (CRE). METHODS: Patients from the Consortium on Resistance Against Carbapenem in Klebsiella and Other Enterobacteriaceae (CRACKLE-1) from December 24, 2011 to October 1, 2014 with wound cultures positive for CRE were included in the study. Predictors of surgical intervention were analyzed...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29021784/synthetic-peptides-to-target-stringent-response-controlled-virulence-in-a-pseudomonas-aeruginosa-murine-cutaneous-infection-model
#2
Daniel Pletzer, Heidi Wolfmeier, Manjeet Bains, Robert E W Hancock
Microorganisms continuously monitor their surroundings and adaptively respond to environmental cues. One way to cope with various stress-related situations is through the activation of the stringent stress response pathway. In Pseudomonas aeruginosa this pathway is controlled and coordinated by the activity of the RelA and SpoT enzymes that metabolize the small nucleotide secondary messenger molecule (p)ppGpp. Intracellular ppGpp concentrations are crucial in mediating adaptive responses and virulence. Targeting this cellular stress response has recently been the focus of an alternative approach to fight antibiotic resistant bacteria...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29021202/adjunctive-antibiotics-for-drained-skin-abscesses-improve-clinical-cure-rate
#3
REVIEW
David A Talan
No abstract text is available yet for this article.
October 11, 2017: Evidence-based Medicine
https://www.readbyqxmd.com/read/29020285/impact-of-systemic-antibiotics-on-staphylococcus-aureus-colonization-and-recurrent-skin-infection
#4
Patrick G Hogan, Marcela Rodriguez, Allison M Spenner, Jennifer M Brenneisen, Mary G Boyle, Melanie L Sullivan, Stephanie A Fritz
Background: Staphylococcus aureus colonization poses risk for subsequent skin and soft tissue infection (SSTI). We hypothesized that including systemic antibiotics in the management of S. aureus SSTI, in conjunction with incision and drainage, would reduce S. aureus colonization and incidence of recurrent infection. Methods: We prospectively evaluated 383 children with S. aureus SSTI requiring incision and drainage and S. aureus colonization in the anterior nares, axillae, or inguinal folds at baseline screening...
August 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28989569/clinical-profile-of-diabetes-at-diagnosis-among-children-and-adolescents-at-an-endocrine-clinic-in-ghana
#5
Emmanuel Ameyaw, Serwah B Asafo-Agyei, Sumithira Thavapalan, Angela C Middlehurst, Graham D Ogle
AIM: To determine the clinical features of diabetes in children and adolescents in Ghana. METHODS: Retrospective review of clinical features of all children and adolescents with new-onset diabetes seen at the paediatric endocrinology clinic of Komfo Anokye Teaching Hospital in Kumasi, from February 2012 to Auguest 2016. RESULTS: One hundred and six subjects presented with diabetes. Ninety (84.9%) were diagnosed by clinical features and family history as type 1, and 16 (15...
September 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28987525/subgroup-analysis-of-antibiotic-treatment-for-skin%C3%A2-abscesses
#6
David A Talan, Gregory J Moran, Anusha Krishnadasan, Fredrick M Abrahamian, Frank Lovecchio, David J Karras, Mark T Steele, Richard E Rothman, William R Mower
STUDY OBJECTIVE: Two large randomized trials recently demonstrated efficacy of methicillin-resistant Staphylococcus aureus (MRSA)-active antibiotics for drained skin abscesses. We determine whether outcome advantages observed in one trial exist across lesion sizes and among subgroups with and without guideline-recommended antibiotic indications. METHODS: We conducted a planned subgroup analysis of a double-blind, randomized trial at 5 US emergency departments, demonstrating superiority of trimethoprim-sulfamethoxazole (320/1,600 mg twice daily for 7 days) compared with placebo for patients older than 12 years with a drained skin abscess...
October 4, 2017: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/28950196/a-therapeutic-polyelectrolyte-vitamin-c-nanoparticulate-system-in-polyvinyl-alcohol-alginate-hydrogel-an-approach-to-treat-skin-and-soft-tissue-infections-caused-by-staphylococcus-aureus
#7
Liya George, M C Bavya, K Vimal Rohan, R Srivastava
Staphylococcus aureus infections affecting the skin and soft tissues are of significant health concern and an unmet need to be addressed. The lack of drug penetration into the infectious site is the main clinical challenge. Once the pathogen invades the wounded skin, it attenuates biological response pathways, leading to chronic infection. Wound infections are associated with alkaline pH due to the presence of bacteria, whereas creation of an acidic environment around the wound bed promotes faster healing. Herein, we develop injectable drug loaded nanoparticulate system of vancomycin encapsulated polycaprolactone nanoparticles coated with polyelectrolyte-Vitamin C in polyvinyl alcohol-alginate gel (D-PCL-PVc-PVA(Alg)...
September 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28939137/autosomal-dominant-hyper-ige-syndrome-in-the-usidnet-registry
#8
Yael Gernez, Alexandra F Freeman, Steven M Holland, Elizabeth Garabedian, Niraj C Patel, Jennifer M Puck, Kathleen E Sullivan, Javeed Akhter, Elizabeth Secord, Karin Chen, Rebecca Buckley, Elie Haddad, Hans D Ochs, Ramsay Fuleihan, John Routes, Mica Muskat, Patricia Lugar, Julien Mancini, Charlotte Cunningham-Rundles
BACKGROUND: Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare condition. OBJECTIVE: Data from the USIDNET Registry provide a resource to examine the characteristics of patients with rare immune deficiency diseases. METHODS: A query was submitted to the USIDNET requesting deidentified data for patients with physician-diagnosed AD-HIES through July 2016. RESULTS: Data on 85 patients diagnosed with AD-HIES (50 males; 35 females) born between 1950 and 2013, collected by 14 physicians from 25 states and Quebec, were entered into the USIDNET Registry by July 2016...
September 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28938255/scabies-periorbital-cellulitis-and-recurrent-skin-abscesses-due-to-panton-valentine-leukocidin-positive-s-aureus-mimic-hyper-ige-syndrome-in-an-infant
#9
Renate Krüger, Leif G Hanitsch, Rasmus Leistner, Sylke Schneider-Burrus, Pia-Alice Hoppe, Sylvia Steinberg, Fabian Hauck, Horst von Bernuth
We describe the clinical course of a two-month-old infant that was evaluated for autosomal dominant Hyper IgE Syndrome based on eczema, periorbital cellulitis, skin abscesses, increased total IgE levels and blood eosinophilia. However, scabies and nasal colonization by Panton-Valentine Leucocidin positive S. aureus were eventually diagnosed. After specific treatment the child was asymptomatic.
September 20, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28919346/clinical-outcomes-in-patients-hospitalized-with-cellulitis-treated-with-oral-clindamycin-and-trimethoprim-sulfamethoxazole-the-role-of-weight-based-dosing
#10
Kristin K Cox, Bruce Alexander, Daniel J Livorsi, Brett H Heintz
OBJECTIVES: Trimethoprim/sulfamethoxazole (TMP/SMX) and clindamycin are frequently prescribed to treat cellulitis. The primary objective was to determine if weight-based dosing of these antibiotics is associated with better outcomes in cellulitis. The secondary objective was to assess variables associated with clinical failure among hospitalized patients with cellulitis with or without cutaneous abscess. METHODS: This multi-center retrospective cohort study was conducted from January 1, 2010 to September 4, 2014...
September 15, 2017: Journal of Infection
https://www.readbyqxmd.com/read/28903801/s-aureus-infections-in-chicago-2006-2014-increase-in-ca-mssa-and-decrease-in-mrsa-incidence
#11
M Ellen Acree, Ethan Morgan, Michael Z David
OBJECTIVE To examine trends in Staphylococcus aureus infections in adults and children at a single academic center in 2006-2014. DESIGN Retrospective cohort study. SETTING Inpatient, outpatient, and emergency department settings in a private, tertiary referral center. PATIENTS Patients with an infection culture that grew S. aureus in January 1, 2006, through March 31, 2014. METHODS The first isolate per year for each patient was classified as community-associated (CA-), healthcare-associated (HA-), or HA-community-onset S...
October 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28902844/melioidosis-in-lower-provincial-cambodia-a-case-series-from-a-prospective-study-of-sepsis-in-takeo-province
#12
Kevin L Schully, Catherine M Berjohn, Angela M Prouty, Amitha Fitkariwala, Tin Som, Darith Sieng, Michael J Gregory, Andrew Vaughn, Sim Kheng, Vantha Te, Christopher A Duplessis, James V Lawler, Danielle V Clark
Melioidosis is a severe infectious disease caused by the gram-negative soil bacterium Burkholderia pseudomallei. Melioidosis is well known to be a major cause of morbidity and mortality in Southeast Asia, particularly in Thailand. However, melioidosis remains underreported in surrounding areas such as Cambodia. We report a case series of melioidosis in seven patients from Takeo Province, Cambodia. The patients, aged 24-65 years, were enrolled from May 2014 to May 2015 during a one year prospective study of sepsis at Takeo Provincial Hospital...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28900424/the-impact-of-the-staphylococcus-aureus-virulome-on-infection-in-a-developing-country-a-cohort-study
#13
Marthe Lebughe, Patrick Phaku, Silke Niemann, Dieudonné Mumba, Georg Peters, Jean-Jacques Muyembe-Tamfum, Alexander Mellmann, Lena Strauß, Frieder Schaumburg
We performed a cohort study to analyze the virulome of Staphylococcus aureus from the Democratic Republic of the Congo using whole genome sequencing and to assess its impact on the course of S. aureus infections. Community-associated S. aureus from nasal colonization (n = 100) and infection (n = 86) were prospectively collected. Phenotypic susceptibility testing and WGS was done for each isolate. WGS data were used to screen for 79 different virulence factors and for genotyping purposes (spa typing, multilocus sequence typing)...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28859442/emerging-multidrug-resistance-in-community-associated-staphylococcus-aureus-involved-in-skin-and-soft-tissue-infections-and-nasal-colonization
#14
Grace C Lee, Steven D Dallas, Yufeng Wang, Randall J Olsen, Kenneth A Lawson, James Wilson, Christopher R Frei
Background: Staphylococcus aureus is a major pathogen causing significant morbidity and mortality worldwide. The emergence of MDR S. aureus strains in the community setting has major implications in disease management. However, data regarding the occurrence and patterns of MDR community-associated S. aureus sub-clones is limited. Objectives: To use whole-genome sequences to describe the diversity and distribution of resistance mechanisms among community-associated S...
September 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28859018/analysis-of-invasive-community-acquired-methicillin-susceptible-staphylococcus-aureus-infections-during-a-period-of-declining-ca-mrsa-infections-at-a-large-children-s-hospital
#15
Kristina G Hultén, Edward O Mason, Linda B Lamberth, Andrea R Forbes, Paula A Revell, Sheldon L Kaplan
BACKGROUND: The epidemiology of community acquired (CA) Staphylococcus aureus infections is changing in the United States. We investigated the current epidemiology of S. aureus infections at Texas Children's Hospital (TCH). METHODS: Patients with CA-S. aureus skin and soft tissue (SSTI) and invasive infections were retrospectively identified from 1/1/2007-12/31/2014. Invasive CA-MSSA isolates were characterized by PFGE, Spa typing, agr type and presence of lukSF-PV (pvl) genes...
August 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28852669/decreasing-incidence-of-skin-and-soft-tissue-infections-with-a-seasonal-pattern-at-an-academic-medical-center-2006-2014
#16
Ethan Morgan, Robert S Daum, Michael Z David
Background.  The incidence of skin and soft tissue infections (SSTIs) in the United States increased sharply after 2000 with the emergence of USA300 methicillin-resistant Staphylococcus aureus. We examined trends in SSTI incidence in 2006-2014 at the University of Chicago Medicine (UCM). Methods.  Data were obtained for patient encounters at UCM with an International Classification of Diseases, Ninth Revision-coded SSTI diagnosis between January 1, 2006 and March 31, 2014. Incidence density was calculated per 1000 encounters by quarter and year...
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28835332/prospective-observational-study-to-assess-the-need-for-postoperative-antibiotics-following-surgical-incision-and-drainage-of-skin-and-soft-tissue-abscess-in-pediatric-patients
#17
Ian C Glenn, Nicholas E Bruns, Oliver S Soldes, Todd A Ponsky
BACKGROUND: Post-operative antibiotics are often utilized for skin and soft tissue infection (SSTI) requiring surgical incision and drainage (I&D). We propose that antibiotics are unnecessary following I&D. METHODS: Patients aged 3months to 6years with SSTI of the buttocks, groin, thigh, and/or labia requiring I&D were prospectively enrolled. The primary outcome was the proportion of patients requiring re-drainage and/or antibiotics for SSTI recurrence, within 30days...
August 7, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28818282/the-obesity-paradox-in-patients-with-severe-soft-tissue-infections
#18
Arturo J Rios-Diaz, Elissa Lin, Katherine Williams, Wei Jiang, Vihas Patel, Naomi Shimizu, David Metcalfe, Olubode A Olufajo, Zara Cooper, Joaquim Havens, Ali Salim, Reza Askari
BACKGROUND: The "obesity paradox" has been demonstrated in chronic diseases but not in acute surgery. We sought to determine whether obesity is associated with improved outcomes in patients with severe soft tissue infections (SSTIs). METHODS: The 2006 to 2010 Nationwide Inpatient Sample was used to identify adult patients with SSTIs. Patients were categorized into nonobese and obese (nonmorbid [body mass index 30 to 39.9] and morbid [body mass index ≥ 40]). Logistic regression provided risk-adjusted association between obesity categories and inhospital mortality...
September 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/28811343/comparative-genomics-of-escherichia-coli-isolated-from-skin-and-soft-tissue-and-other-extraintestinal-infections
#19
Amit Ranjan, Sabiha Shaik, Nishant Nandanwar, Arif Hussain, Sumeet K Tiwari, Torsten Semmler, Savita Jadhav, Lothar H Wieler, Munirul Alam, Rita R Colwell, Niyaz Ahmed
Escherichia coli, an intestinal Gram-negative bacterium, has been shown to be associated with a variety of diseases in addition to intestinal infections, such as urinary tract infections (UTIs), meningitis in neonates, septicemia, skin and soft tissue infections (SSTIs), and colisepticemia. Thus, for nonintestinal infections, it is categorized as extraintestinal pathogenic E. coli (ExPEC). It is also an opportunistic pathogen, causing cross infections, notably as an agent of zoonotic diseases. However, comparative genomic data providing functional and genetic coordinates for ExPEC strains associated with these different types of infections have not proven conclusive...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28803587/the-rise-of-methicillin-resistant-staphylococcus-aureus-now-the-dominant-cause-of-skin-and-soft-tissue-infection-in-central-australia
#20
E Macmorran, S Harch, E Athan, S Lane, S Tong, L Crawford, S Krishnaswamy, S Hewagama
This study aimed to examine the epidemiology and treatment outcomes of community-onset purulent staphylococcal skin and soft tissue infections (SSTI) in Central Australia. We performed a prospective observational study of patients hospitalised with community-onset purulent staphylococcal SSTI (n = 160). Indigenous patients accounted for 78% of cases. Patients were predominantly young adults; however, there were high rates of co-morbid disease. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was the dominant phenotype, accounting for 60% of cases...
October 2017: Epidemiology and Infection
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