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Inflammatory bowel disease

Ruth Ann Marrie, Randy Walld, James M Bolton, Jitender Sareen, Scott B Patten, Alexander Singer, Lisa M Lix, Carol A Hitchon, Renée El-Gabalawy, Alan Katz, John D Fisk, Charles N Bernstein
OBJECTIVE: We determined the association between any common mental disorder (CMD: depression, anxiety disorder, bipolar disorder) and mortality and suicide in three immune-mediated inflammatory diseases (IMID), inflammatory bowel disease (IBD), multiple sclerosis (MS) and rheumatoid arthritis (RA), versus age-, sex- and geographically-matched controls. METHODS: Using administrative data, we identified 28,384 IMID cases (IBD: 8695; MS: 5496; RA: 14,503) and 141,672 matched controls...
June 7, 2018: General Hospital Psychiatry
Xiaoying S Zhong, John H Winston, Xiuju Luo, Kevin T Kline, Syed Z Nayeem, Yingzi Cong, Tor C Savidge, Roderick H Dashwood, Don W Powell, Qingjie Li
Background & Aims: Early life adversity is considered a risk factor for the development of gastrointestinal diseases, including inflammatory bowel disease. We hypothesized that early life colonic inflammation causes susceptibility to aggravated overexpression of interleukin (IL)1β. Methods: We developed a 2-hit rat model in which neonatal inflammation (NI) and adult inflammation (AI) were induced by trinitrobenzene sulfonic acid. Results: Aggravated immune responses were observed in NI + AI rats, including a sustained up-regulation of IL1β and other cytokines...
2018: Cellular and Molecular Gastroenterology and Hepatology
Lori M Gawron
No abstract text is available yet for this article.
March 2018: Gastroenterology & Hepatology
Guy H T Worley, Nicola S Fearnhead, Steven R Brown, Austin G Acheson, Matthew J Lee, Omar D Faiz
INTRODUCTION: The second ACPGBI Ileoanal Pouch Registry (IPR) report was released in July 2017 following a first report in 2012. This article provides a summary of data derived from the most recent IPR report (1). METHOD: The IPR is an electronic database of voluntarily submitted data including patient demographics, disease, intra and post-operative factors submitted by consultant surgeons or delegates. Data up to 31st March 2017 have been analysed for this report...
June 21, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
Christina Ong, Marion M Aw, Maria Janelle Liwanag, Quak Seng Hock, Phua Kong Boo
BACKGROUND AND AIMS: Epidemiological studies on pediatric-onset inflammatory bowel disease (PIBD) are scarce in Southeast Asia (SEA). Phenotypes of PIBD in Asian were reportedly more complicated than Caucasian in the same western centres. This study aims to evaluate the incidence trend and clinical characteristics of PIBD in a SEA cohort in Singapore over a 22-year period (1994-2015). METHODS: Case records of PIBD ≤ 18years from the only two tertiary pediatric hospitals in Singapore were reviewed for relevant data...
June 21, 2018: Journal of Digestive Diseases
Gertrude van den Brink, Martha A C van Gaalen, Marieke Zijlstra, Lissy de Ridder, C Janneke van der Woude, Johanna C Escher
AIM: It can be difficult for adolescents with inflammatory bowel disease (IBD) to make the transition from paediatric to adult care. We studied the outcomes of this process and defined what constituted a successful transition. METHODS: In 2008, 50 adolescents who attended our IBD transition clinic completed IBD-yourself, a self-efficacy questionnaire that we had previously developed and validated. We approached the subjects in 2014, two to six years after they transferred to adult care, and 35 agreed to take part in the current study...
June 21, 2018: Acta Paediatrica
Feng Zhu, Dengyu Feng, Tenghui Zhang, Lili Gu, Weiming Zhu, Zhen Guo, Yi Li, Nan Lu, Jianfeng Gong, Ning Li
BACKGROUND: Patients with inflammatory bowel disease (IBD) have higher incidence of developing nephrolithiasis. Increased uric acid production induced by Saccharomyces cerevisiae exacerbates colitis in mice. We aimed to evaluate the association between serum uric acid level and disease activity in IBD population. METHODS: Four hundred and thirty-five patients enrolled in Jinling Hospital from Jan 1, 2015 to Aug 31, 2017 were included in the retrospective study. Clinical parameters were collected and compared to non-IBD matched controls (n = 51)...
June 21, 2018: Journal of Gastroenterology and Hepatology
Xiao-Meng Wang, Tong Zhao, Xiang Cheng, Ning Guo, Ling-Ling Zhu, Ming Shi, Kui-Wu Wu
OBJECTIVE: To investigate the effects of deficiency of CHL1 in inflammatory bowel disease (IBD). METHODS: Dextran Sulfate Sodium (DSS)-induced colitis model was used to study the effects of deficiency of CHL1 on the development of IBD. Ten CHL1(+/+) mice in C57/BL6 background were randomly divided into CHL1(+/+) group and DSS-induced CHL1(+/+) group. Ten CHL1(-/-) mice in C57/BL6 background were randomly divided into CHL1(-/-) group and DSS-induced CHL1(-/-) group...
January 8, 2018: Chinese Journal of Applied Physiology
Patrícia Guedes Garcia, Liliana Andrade Chebli, Tarsila Campanha da Rocha Ribeiro, Pedro Duarte Gaburri, Fabio Heleno de Lima Pace, Kátia Valéria Bastos Dias Barbosa, Lívia Almeida Costa, William de Almeida Cruz, Isabelle Carvalho de Assis, Bernardo Rodriguez Mendes Moraes, Alexandre Zanini, Julio Maria Fonseca Chebli
PURPOSE: The prospective assessment of Clostridium difficile infection (CDI) impact in inflammatory bowel disease (IBD) flare in outpatient setting has been poorly investigated. We aimed to evaluate the prevalence and the associated factors with CDI in IBD outpatients presenting colitis flares as well as the outcomes following treatment. METHODS: In this prospective cohort study, conducted from October, 2014, to July, 2016, 120 IBD patients (55% presenting colitis flare) and 40 non-IBD controls were assessed for CDI...
June 21, 2018: International Journal of Colorectal Disease
Erin K Crowley, Caitriona M Long-Smith, Amy Murphy, Elaine Patterson, Kiera Murphy, Denise M O'Gorman, Catherine Stanton, Yvonne M Nolan
Accumulating evidence demonstrates that dietary supplementation with functional food ingredients play a role in systemic and brain health as well as in healthy ageing. Conversely, deficiencies in calcium and magnesium as a result of the increasing prevalence of a high fat/high sugar "Western diet" have been associated with health problems such as obesity, inflammatory bowel diseases, and cardiovascular diseases, as well as metabolic, immune, and psychiatric disorders. It is now recognized that modulating the diversity of gut microbiota, the population of intestinal bacteria, through dietary intervention can significantly impact upon gut health as well as systemic and brain health...
June 20, 2018: Marine Drugs
Eva Karaskova, Jana Volejnikova, Dusan Holub, Maria Velganova-Veghova, Lucie Sulovska, Vladimír Mihal, Monika Horvathova, Dagmar Pospisilova
AIM: Hepcidin is a central regulator of iron homeostasis. Its production is also influenced by systemic inflammation. The aims of this study were to compare hepcidin levels in paediatric patients newly diagnosed with Crohn's disease (CD) and ulcerative colitis (UC) and to determine the association of hepcidin levels with laboratory and clinical parameters of inflammatory bowel disease (IBD) activity. METHODS: Children with newly diagnosed IBD between January 2012 and September 2016 were enrolled in this comparative cross-sectional study...
June 20, 2018: Journal of Paediatrics and Child Health
Yoichi Kakuta, Yosuke Kawai, Daisuke Okamoto, Tetsuya Takagawa, Kentaro Ikeya, Hirotake Sakuraba, Atsushi Nishida, Shoko Nakagawa, Miki Miura, Takahiko Toyonaga, Kei Onodera, Masaru Shinozaki, Yoh Ishiguro, Shinta Mizuno, Masahiro Takahara, Shunichi Yanai, Ryota Hokari, Tomoo Nakagawa, Hiroshi Araki, Satoshi Motoya, Takeo Naito, Rintaro Moroi, Hisashi Shiga, Katsuya Endo, Taku Kobayashi, Makoto Naganuma, Sakiko Hiraoka, Takayuki Matsumoto, Shiro Nakamura, Hiroshi Nakase, Tadakazu Hisamatsu, Makoto Sasaki, Hiroyuki Hanai, Akira Andoh, Masao Nagasaki, Yoshitaka Kinouchi, Tooru Shimosegawa, Atsushi Masamune, Yasuo Suzuki
BACKGROUND: Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs. To clarify the best pharmacogenetic test to be used clinically, we performed association studies of NUDT15 variants and haplotypes with AEs, genome-wide association study (GWAS) to discover additional variants, and ROC analysis to select the model to predict severe AEs...
June 19, 2018: Journal of Gastroenterology
Rosa Rosania, Ulrike Von Arnim, Alexander Link, Mirjana Rajilic-Stojanovic, Caspar Franck, Ali Canbay, Peter Malfertheiner, Marino Venerito
BACKGROUND AND AIMS: A negative association between H. pylori and inflammatory bowel disease (IBD) has been previously reported. There were also case reports suggesting a new onset of IBD 6-12 months after H. pylori eradication therapy. In a case-control study we investigated whether previous H. pylori eradication therapy was associated with the risk of developing IBD. METHODS: IBD outpatients with both Crohn´s disease (CD) and ulcerative colitis (UC) were enrolled...
June 2018: Journal of Gastrointestinal and Liver Diseases: JGLD
Tadashi Yokoyama, Akihiko Ohta, Satoshi Motoya, Masakazu Takazoe, Toshitaka Yajima, Masataka Date, Masahiro Nii, Péter Nagy, Yasuo Suzuki, Toshifumi Hibi
Background: US and European guidelines recommend budesonide for the treatment of mild-to-moderate active ileocolic Crohn's disease (CD). However, budesonide has not been approved, and mesalazine is widely used as first-line treatment in Japan. The objective of this study was to evaluate the efficacy and safety of budesonide in patients with mild-to-moderate active CD in Japan. Methods: In this phase 3 noninferiority study (NCT01514240), 112 patients with a baseline Crohn's Disease Activity Index (CDAI) score of 180-400 were randomized to budesonide or mesalazine for 8 weeks...
March 2018: Inflammatory Intestinal Diseases
Cristina O Mǎrginean, Lorena E Meliţ, Maria O Mǎrginean
Segmental colitis associated with diverticulosis (SCAD) is manifested by active chronic inflammation of the colonic segments affected by diverticulosis, luminal-mucosal inflammation, independent of the presence of inflammation within and/or around the diverticula, and it usually spares the rectum. We present the case of a 15-year-old female admitted to our clinic due to lower digestive hemorrhage and abdominal pain in the previous week, associated with fever 1 day prior to admission. The patient had pallor, painful abdomen upon palpation, accelerated bowel movements, and macroscopic evidence of blood in the stools...
2018: Frontiers in Pediatrics
Alain P Gobert, Nicole T Al-Greene, Kshipra Singh, Lori A Coburn, Johanna C Sierra, Thomas G Verriere, Paula B Luis, Claus Schneider, Mohammad Asim, Margaret M Allaman, Daniel P Barry, John L Cleveland, Christina E Destefano Shields, Robert A Casero, M Kay Washington, M Blanca Piazuelo, Keith T Wilson
Polyamines have been implicated in numerous biological processes, including inflammation and carcinogenesis. Homeostatic regulation leads to interconversion of the polyamines putrescine and the downstream metabolites spermidine and spermine. The enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, contributes to regulation of polyamine levels, but can also have other effects. We have implicated SMOX in gastric inflammation and carcinogenesis due to infection by the pathogen Helicobacter pylori ...
2018: Frontiers in Immunology
Annika Reinhardt, Immo Prinz
γδ T cells, αβ T cells, and innate lymphoid cells (ILCs) are capable of producing interleukin (IL)-17A, IL-17F, and IL-22. Among these three families of lymphocytes, it is emerging that γδ T cells are, at least in rodents, the main source of these key pro-inflammatory cytokines. γδ T cells were implicated in multiple inflammatory and autoimmune diseases, including psoriasis, experimental autoimmune encephalomyelitis and uveitis, colitis, and rheumatoid arthritis. Recent findings pointed toward a central role of γδ T cells in the pathogenesis of spondyloarthritis (SpA), a group of inflammatory rheumatic diseases affecting the axial skeleton...
2018: Frontiers in Immunology
Yuxia Zhang, Jovana Maksimovic, Bing Huang, David Peter De Souza, Gaetano Naselli, Huan Chen, Li Zhang, Kai Weng, Hanquan Liang, Yanhui Xu, John M Wentworth, Nicholas D Huntington, Alicia Oshlack, Sitang Gong, Axel Kallies, Peter Vuillermin, Min Yang, Leonard C Harrison
How T cells differentiate in the neonate may critically determine the ability of the infant to cope with infections, respond to vaccines and avert allergies. Previously, we found that naïve cord blood CD4+ T cells differentiated toward an IL-4-expressing phenotype when activated in the presence of TGF-β and monocyte-derived inflammatory cytokines, the latter are more highly secreted by infants who developed food allergy. Here, we show that in the absence of IL-2 or IL-12, naïve cord blood CD8+ T cells have a natural propensity to differentiate into IL-4-producing non-classic TC 2 cells when they are activated alone, or in the presence of TGF-β and/or inflammatory cytokines...
2018: Frontiers in Immunology
Mira Y Friedman, Maya Leventer-Roberts, Joseph Rosenblum, Nir Zigman, Iris Goren, Vered Mourad, Natan Lederman, Nurit Cohen, Eran Matz, Doron Z Dushnitzky, Nirit Borovsky, Moshe B Hoshen, Gili Focht, Malka Avitzour, Yael Shachar, Yehuda Chowers, Rami Eliakim, Shomron Ben-Horin, Shmuel Odes, Doron Schwartz, Iris Dotan, Eran Israeli, Zohar Levi, Eric I Benchimol, Ran D Balicer, Dan Turner
Background: Before embarking on administrative research, validated case ascertainment algorithms must be developed. We aimed at developing algorithms for identifying inflammatory bowel disease (IBD) patients, date of disease onset, and IBD type (Crohn's disease [CD] vs ulcerative colitis [UC]) in the databases of the four Israeli Health Maintenance Organizations (HMOs) covering 98% of the population. Methods: Algorithms were developed on 5,131 IBD patients and 2,072 controls, following independent chart review (60% CD and 39% UC)...
2018: Clinical Epidemiology
Kai Wang, Qinqin Yang, Quanxin Ma, Bei Wang, Zhengrui Wan, Minli Chen, Liming Wu
Salvianolic acid A (SAA) is an active phenolic acid derived from Salvia miltiorrhiza Bunge (Danshen). To explore whether SAA has a therapeutic effect against inflammatory bowel disease (IBD), an acute colitis model was induced in rats by administering 3% dextran sodium sulphate (DSS) for one week. SAA in doses of 4 and 8 mg/kg/day was given by tail vein injection during DSS administration. Both dosages of SAA ameliorated the colitis symptoms, with decreases observed in the disease activity index. A high dosage of SAA (8 mg/kg/day) promoted a longer colon length and an improved colonic tissue structure, compared with the DSS-treated rats not receiving SAA...
June 19, 2018: Nutrients
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