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"ssti" OR "cutaneous abscess" OR "cutaneous abscesses"

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https://www.readbyqxmd.com/read/29453940/a-refractory-cutaneous-abscess
#1
Yuka Maya, Wataru Narasaki, Yoshiaki Maeda, Mitsuhito Ota
No abstract text is available yet for this article.
February 14, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29452993/an-in-vitro-evaluation-of-the-efficacy-of-tedizolid-implications-for-the-treatment-of-skin-and-soft-tissue-infections
#2
Pierre Delpech, Muna ALeryan, Brian Jones, Curtis Gemmell, Sue Lang
Skin and soft tissue infections (SSTI) are among the most commonly occurring infections and evidence suggests that these are increasing world-wide. The aetiology is diverse, but Staphylococcus aureus predominate and these are often resistant to antimicrobials that were previously effective. Tedizolid is a new oxazolidinone-class antibacterial indicated for the treatment of adults with SSTI caused by Gram-positive pathogens, including S. aureus. The aim of this study was to evaluate the in vitro efficacy of tedizolid in comparison to other clinically used antibacterials against antibiotic sensitive- and resistant-staphylococci, grown in planktonic cultures and as biofilms reflecting the growth of the microorganism during episodes of SSTI...
January 10, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29373647/eggerthella-lenta-bloodstream-infections-are-associated-with-increased-mortality-following-empiric-piperacillin-tazobactam-tzp-monotherapy-a-population-based-cohort-study
#3
Alejandra Ugarte-Torres, Mark R Gillrie, Thomas P Griener, Deirdre L Church
Background: Eggerthella lenta is a non-sporulating anaerobic gram-positive bacilli associated with polymicrobial intra-abdominal infections. Recently, E. lenta has been recognized as an important cause of anaerobic blood-stream infections (BSI) associated with high mortality. E. lenta has been reported to have high minimal inhibitory concentrations (MICs) to piperacillin-tazobactam (TZP), a broad-spectrum antibiotic with anaerobic coverage commonly used in multiple centers for empiric treatment of abdominal sepsis...
January 24, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29370771/characterization-of-staphylococcus-aureus-isolated-from-patients-with-burns-in-a-regional-burn-center-southeastern-china
#4
Kaisen Chen, Shirong Lin, Peiqun Li, Qiuyue Song, Dong Luo, Tao Liu, Lingbing Zeng, Wei Zhang
BACKGROUND: S.aureus is a predominant pathogen that causes infection in critically ill patients, but little information exists regarding the characterization of S. aureus from different sources in burn patients in southeastern China. METHODS: We enrolled 125 patients with S. aureus infection in burns center between Jan 2014 and Dec 2015. S. aureus isolates were characterized by antimicrobial susceptibility test, toxin gene detection, and molecular typing with multilocus sequence type, staphylococcal protein A (spa) type, and staphylococcal cassette chromosome mec (SCCmec) type...
January 25, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29354655/guidelines-vs-actual-management-of-skin-and-soft-tissue-infections-in-the-emergency-department
#5
Rahul S Kamath, Deepthi Sudhakar, Julianna G Gardner, Vagish Hemmige, Hossam Safar, Daniel M Musher
Background: Infections of skin and soft tissue (SSTI) commonly cause visits to hospital emergency departments (EDs). The Infectious Diseases Society of America (IDSA) has published guidelines for the management of SSTI, but it is unclear how closely these guidelines are followed in practice. Methods: We reviewed records of patients seen in the ED at a large tertiary care hospital to determine guidelines adherence in 4 important areas: the decision to hospitalize, choice of antibiotics, incision and drainage (I&D) of abscesses, and submission of specimens for culture...
January 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29351926/bet-1-is-routine-irrigation-of-a-cutaneous-abscess-necessary
#6
Joshua Badour, Matt Singh, Jeffrey Jones
A short cut review was carried out to establish whether the addition of irrigation of the abscess cavity improved outcomes after incision and drainage of a cutaneous abscess. One paper presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of this paper are tabulated. It is concluded that in adult patients with cutaneous abscesses routine irrigation during incision and drainage does not improve clinical outcomes...
February 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29346119/the-role-of-tedizolid-in-skin-and-soft-tissue-infections
#7
Emilio Bouza, Patricia Muñoz, Almudena Burillo
PURPOSE OF REVIEW: Tedizolid is a second-generation oxazolidinone with activity against Gram-positive bacteria, including MRSA isolates resistant to linezolid. Pivotal clinical trials showed that tedizolid at 200 mg once-daily for 6 days is not inferior to linezolid 600 mg twice daily for 10 days in patients with SSTI. The comparison of adverse events is favorable to tedizolid under the circumstances of the clinical trials. This is a review of recent literature on tedizolid, its use in special populations and potential adverse effects...
January 15, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29337704/the-what-when-and-how-in-performing-and-interpreting-microbiological-diagnostic-tests-in-skin-and-soft-tissue-infections
#8
Carolina Navarro-San Francisco, Patricia Ruiz-Garbajosa, Rafael Cantón
PURPOSE OF REVIEW: To summarize and classify the most recent and relevant microbiological studies for each type of skin and soft tissue infection (SSTI). RECENT FINDINGS: Following Infectious Diseases Society of America and Food and Drug Administration classifications of SSTIs, we differentiate between two large groups, the superficial or uncomplicated infections and the complicated infections with deep involvement. It is not usually necessary to obtain microbiological samples in uncomplicated infections, except in cases of recurrences or for epidemiological control purposes...
January 11, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29337217/peptide-drug-stability-the-anti-inflammatory-drugs-pep19-2-5-and-pep19-4lf-in-cream-formulation
#9
Nicole Kuhlmann, Lena Heinbockel, Wilmar Correa, Thomas Gutsmann, Torsten Goldmann, Uwe Englisch, Klaus Brandenburg
In previous years, we developed anti-infective drugs based on antimicrobial peptides (AMPs), which have been shown to effectively block severe infections and inflammation in vitro as well as in vivo. Besides systemic application, the occurrence of severe local infections necessitates a topical application for example in the case of severe skin and soft tissue infections (SSTI). Recent investigations show that the synthetic anti-lipopolysaccharide peptide (SALP) Pep19-2.5 (Aspidasept® I) and a variant called Pep19-4LF (Aspidasept® II) are able to supress inflammation reactions also in keratinocytes, Langerhans cells, and dendritic cells from the skin...
January 11, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29299899/clinical-guidelines-for-the-antibiotic-treatment-for-community-acquired-skin-and-soft-tissue-infection
#10
Yee Gyung Kwak, Seong Ho Choi, Tark Kim, Seong Yeon Park, Soo Hong Seo, Min Bom Kim, Sang Ho Choi
Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. This clinical guideline provides recommendations for the diagnosis and management of SSTI, including impetigo/ecthyma, purulent skin and soft tissue infection, erysipelas and cellulitis, necrotizing fasciitis, pyomyositis, clostridial myonecrosis, and human/animal bite. This guideline targets community-acquired skin and soft tissue infection occurring among adult patients aged 16 years and older...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29298107/longitudinal-case-series-of-staphylococcus-aureus-colonization-and-infection-in-two-cohorts-of-rural-iowans
#11
Tara C Smith, Emily J Hellwig, Shylo E Wardyn, Ashley E Kates, Dipendra Thapaliya
OBJECTIVE: Examine the relationship between colonization with Staphylococcus aureus in the community and symptomatic infection in two cohorts of Iowans. DESIGN: Case series within cohort study. PARTICIPANTS: Rural Iowans selected from the Keokuk Rural Health Study, the Agricultural Health Study, and the Iowa Voter Registry. METHODS: Longitudinal study within established cohorts evaluating documented S. aureus infections with samples available for molecular typing...
January 3, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29261764/pyoderma-outbreak-among-kindergarten-families-association-with-a-panton-valentine-leukocidin-pvl-producing-s-aureus-strain
#12
Rasmus Leistner, Axel Kola, Petra Gastmeier, Renate Krüger, Pia-Alice Hoppe, Sylke Schneider-Burrus, Irina Zuschneid, Nicoletta Wischnewski, Jennifer Bender, Franziska Layer, Michaela Niebank, Carmen Scheibenbogen, Leif G Hanitsch
OBJECTIVES: We report on an outbreak of skin and soft tissue infections (SSTI) among kindergarten families. We analyzed the transmission route and aimed to control the outbreak. METHODS: The transmission route was investigated by nasal screening for Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus (PVL-SA), subsequent microbiological investigation including whole genome sequencing and a questionnaire-based analysis of epidemiological information...
2017: PloS One
https://www.readbyqxmd.com/read/29261121/six-year-retrospective-review-of-hospital-data-on-antimicrobial-resistance-profile-of-staphylococcus-aureus-isolated-from-skin-infections-from-a-single-institution-in-greece
#13
Christina Stefanaki, Alexandra Ieronymaki, Theoni Matoula, Chrysseis Caroni, Evaggelia Polythodoraki, Stella-Eugenia Chryssou, George Kontochristopoulos, Christina Antoniou
Objective: To determine the prevalence of resistant strains of Staphylococcus aureus (S. aureus) isolated from Skin and soft tissue infections (SSTI) to various antibiotics. Material and Methods: All culture-positive results for S. aureus from swabs taken from patients presenting at one Greek hospital with a skin infection between the years 2010-2015 were examined retrospectively. Bacterial cultures, identification of S. aureus and antimicrobial susceptibility testing were performed using the disk diffusion method according to Clinical and Laboratory Standards Institute (CLSI) guidelines and European Committee on Antimicrobial testing (EUCAST) breakpoints...
December 20, 2017: Antibiotics
https://www.readbyqxmd.com/read/29223936/-relationship-between-crowding-and-community-acquired-skin-and-soft-tissues-infections
#14
Marcelo A Beltrán, Horacio J García Del Corro, Mónica Couso, María D Gallo, Antonio Lettieri, Patricia V Barna
The association of the spread of community infections with poverty and overcrowding is well known. In our hospital, located in José C. Paz, we assist sporadic cases of post-cesarean infections caused by community acquired methicillin-resistant Staphylococcus aureus (CaMRSA). In a prospective study of families treated at our hospital, we investigated the relationship between a history of skin and soft tissue infections (SSTI) and extreme overcrowding defined as households with unsatisfied basic needs type 3 (NBI 3)...
2017: Medicina
https://www.readbyqxmd.com/read/29222165/innate-sex-bias-of-staphylococcus-aureus-skin-infection-is-driven-by-%C3%AE-hemolysin
#15
Moriah J Castleman, Srijana Pokhrel, Kathleen D Triplett, Donna F Kusewitt, Bradley O Elmore, Jason A Joyner, Jon K Femling, Geetanjali Sharma, Helen J Hathaway, Eric R Prossnitz, Pamela R Hall
Numerous studies have reported sex bias in infectious diseases, with bias direction dependent on pathogen and site of infection. Staphylococcus aureus is the most common cause of skin and soft tissue infections (SSTIs), yet sex bias in susceptibility to S. aureus SSTI has not been described. A search of electronic health records revealed an odds ratio of 2.4 for S. aureus SSTI in males versus females. To investigate the physiological basis of this bias, we compared outcomes between male and female mice in a model of S...
December 8, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29164118/infections-caused-by-antimicrobial-drug-resistant-saprophytic-gram-negative-bacteria-in-the-environment
#16
Eva Raphael, Lee W Riley
Background: Drug-resistance genes found in human bacterial pathogens are increasingly recognized in saprophytic Gram-negative bacteria (GNB) from environmental sources. The clinical implication of such environmental GNBs is unknown. Objectives: We conducted a systematic review to determine how often such saprophytic GNBs cause human infections. Methods: We queried PubMed for articles published in English, Spanish, and French between January 2006 and July 2014 for 20 common environmental saprophytic GNB species, using search terms "infections," "human infections," "hospital infection...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/29162127/association-of-the-s2-allele-of-the-ssti-polymorphism-in-the-apoc3-gene-with-plasma-apociii-interacts-with-unfavorable-lipid-profiles-to-contribute-to-atherosclerosis-in-the-li-ethnic-group-in-china
#17
Minzeng Sun, Lin Chen, Hui Liu, Lihui Ma, Tiansong Wang, Yueli Liu
BACKGROUND: The SstI polymorphism in the apolipoprotein 3 gene (apoC3) has been identified in many ethnic groups. In addition, the S2 allele of the SstI polymorphism is shown to be associated with increased plasma triglyceride (TG) levels. Plasma apoCIII is an important atherogenic factor, which interrupts lipid metabolism and is positively associated with plasma TG levels. However, the existence of the SstI polymorphism in the Li ethnic group in China remains to be confirmed. The relationship between the S2 allele of the SstI polymorphism and plasma apoCIII or TG and their roles in atherosclerosis are also unknown...
November 21, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29124834/prevalence-and-characterisation-of-staphylococcus-aureus-causing-community-acquired-skin-and-soft-tissue-infections-on-java-and-bali-indonesia
#18
Dewi Santosaningsih, Sanarto Santoso, Nanik Setijowati, Harun A Rasyid, Nyoman S Budayanti, Ketut Suata, Dicky B Widhyatmoko, Priyo B Purwono, Kuntaman Kuntaman, Damayanti Damayanti, Cita R S Prakoeswa, Mitchell Laurens, Josephine W I van Nierop, Geraldine L Nanninga, Neline Oudenes, Michelle de Regt, Susan V Snijders, Henri A Verbrugh, Juliëtte A Severin
OBJECTIVES: To define the role of Staphylococcus aureus in community settings among patients with skin and soft tissue infections (SSTI) in Indonesia. METHODS: Staphylococcus aureus were cultured from anterior nares, throat and wounds of 567 ambulatory patients presenting with SSTI. The mecA gene and genes encoding Panton-Valentine leukocidin (PVL; lukF-PV and lukS-PV) and exfoliative toxin (ET; eta and etb) were determined by PCR. Clonal relatedness among methicillin-resistant S...
November 10, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29102120/antimicrobial-resistance-in-clinical-escherichia-coli-isolated-from-companion-animals-in-australia
#19
Sugiyono Saputra, David Jordan, Tahlia Mitchell, Hui San Wong, Rebecca J Abraham, Amanda Kidsley, John Turnidge, Darren J Trott, Sam Abraham
Multidrug-resistant (MDR) Escherichia coli have become a major public health concern to both humans and animal health. While the frequency of antimicrobial resistance (AMR) in clinical E. coli is monitored regularly in human medicine, current frequency of AMR in companion animals remains unknown in Australia. In this study we conducted antimicrobial susceptibility testing (AST) and where possible, determined potential risk factors for MDR infection among 883 clinical Escherichia coli isolated from dogs (n=514), cats (n=341) and horses (n=28)...
November 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/29090420/soft-tissue-infection-secondary-to-cellulitis-killed-st-john-of-the-cross-1542-1591
#20
Raffaella Bianucci, Otto Appenzeller, Peter Evans, Philippe Charlier, Antonio Perciaccante
PURPOSE: St. John of the Cross (1542-1591) died aged 49 years after 3 months of excruciating pain following a trivial lesion in his right foot. Erysipelas, a superficial bacterial infection of the skin, and subsequent sepsis were previously suggested as the cause of his death. Here, an alternative diagnosis is proposed. METHODS: An accurate perusal of his biography allowed the symptomatology, the clinical evolution, the depth of the infection and the associated systemic manifestations displayed by Fray John to be reconstructed...
October 31, 2017: Infection
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