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https://www.readbyqxmd.com/read/28435490/correlation-of-physical-exam-findings-with-fever-in-patients-with-skin-and-soft-tissue-infections
#1
Jillian Mongelluzzo, Brian Tu, Barbara Grimes, Sharvina Ziyeh, Jonathan Fortman, Jersey Neilson, Robert M Rodriguez
INTRODUCTION: The objectives of this study were to determine the prevalence of fever in adult ED patients with skin and soft tissue infections (SSTI) and to determine which, if any, physical exam, radiograph and laboratory test findings were associated with fever. METHODS: We conducted a prospective, observational study at an urban county trauma center of adults who presented to the ED for evaluation of suspected SSTI. ED providers measured area of erythema and induration using a tape measure, and completed data sheets indicating comorbid conditions and the presence or absence of physical exam findings...
April 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28419202/genomic-characterization-of-usa300-mrsa-to-evaluate-intraclass-transmission-and-recurrence-of-ssti-among-high-risk-military-trainees
#2
Eugene V Millar, Gregory K Rice, Emad M Elassal, Carey D Schlett, Jason W Bennett, Cassie L Redden, Deepika Mor, Natasha N Law, David R Tribble, Theron Hamilton, Michael W Ellis, Kimberly A Bishop-Lilly
Background.: Military trainees are at increased risk for methicillin-resistant Staphylococcus aureus (MRSA) skin and soft tissue infection (SSTI). Whole genome sequencing (WGS) can refine our understanding of MRSA transmission and microevolution in congregate settings. Methods.: We conducted a prospective case-control study of SSTI among US Army Infantry trainees at Fort Benning, GA from July 2012-December 2014. We identified clusters of USA300 MRSA SSTI within select training classes and performed WGS on clinical isolates...
April 17, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28416258/-description-of-3-cases-of-skin-and-soft-tissue-infections-caused-by-streptococcus-pneumoniae
#3
Mónica Elisabeth Martínez, Sandra Liliana Grenón, Oscar Herminio López, Lorena Beatriz Leguizamón, Marta Eugenia Mollerach, Martha Helena von Specht
The role of Streptococcus pneumoniae as a causative agent of skin and soft tissue infections (SSTI) is unusual and its clinical interpretation is difficult. We describe here three cases of SSTI due to S. pneumoniae in patients admitted to the Provincial Pediatric Hospital of Misiones, Argentina that were detected during 10 years of invasive disease (ID) surveillance documented in 2010, 2011 and 2015. These cases involved two girls aged 8 and 7 months old, and a two-year-old male child with diagnoses of gluteal abscess, preseptal cellulites and pyoderma respectively...
April 14, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28385138/community-acquired-syndromes-causing-morbidity-and-mortality-in-australia%C3%A2
#4
Shweta Sharma, Emmy Sneath, Allen C Cheng, N Deborah Friedman
The clinical and economic burden of infectious diseases is a substantial public health problem. The determination of the relative contributions of these diseases to the overall healthcare burden can inform priority setting, planning, and decision-making in healthcare and establish a baseline for future comparisons. Few recent studies have presented definitive data on the incidence of infectious diseases requiring hospitalisation in the Southern Hemisphere. We identified the age-specific number of hospitalisations and severe infections requiring intensive care unit admissions in the Geelong region...
March 31, 2017: Communicable Diseases Intelligence Quarterly Report
https://www.readbyqxmd.com/read/28378613/diagnosis-and-management-of-skin-and-soft-tissue-infections-ssti-a-literature-review-and-consensus-statement-an-update
#5
S Esposito, M Bassetti, E Concia, G De Simone, F G De Rosa, P Grossi, A Novelli, F Menichetti, N Petrosillo, M Tinelli, M Tumbarello, M Sanguinetti, P Viale, M Venditti, C Viscoli
Skin and soft-tissue infections (SSTIs) are among the most common bacterial infections, posing considerable diagnostic and therapeutic challenges. Fourteen members of the Italian Society of Infectious Diseases, after a careful review of the most recent literature using Medline database and their own clinical experience, updated a previous paper published in 2011 by preparing a draught manuscript of the statements. The manuscript was successively reviewed by all members and ultimately re-formulated the present manuscript during a full day consensus meeting...
April 5, 2017: Journal of Chemotherapy
https://www.readbyqxmd.com/read/28377579/vlp-based-vaccine-induces-immune-control-of-staphylococcus-aureus-virulence-regulation
#6
Seth M Daly, Jason A Joyner, Kathleen D Triplett, Bradley O Elmore, Srijana Pokhrel, Kathryn M Frietze, David S Peabody, Bryce Chackerian, Pamela R Hall
Staphylococcus aureus is the leading cause of skin and soft tissue infections (SSTIs) and mounting antibiotic resistance requires innovative treatment strategies. S. aureus uses secreted cyclic autoinducing peptides (AIPs) and the accessory gene regulator (agr) operon to coordinate expression of virulence factors required for invasive infection. Of the four agr alleles (agr types I-IV and corresponding AIPs1-4), agr type I isolates are most frequently associated with invasive infection. Cyclization via a thiolactone bond is essential for AIP function; therefore, recognition of the cyclic form of AIP1 may be necessary for antibody-mediated neutralization...
April 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28363171/severe-soft-tissue-injuries-of-the-upper-extremity-in-motor-vehicle-crashes-involving-partial-ejection-the-protective-role-of-side-curtain-airbags
#7
Robert Kaufman, Laura Fraade-Blanar, Angelo Lipira, Jeffrey Friedrich, Eileen Bulger
INTRODUCTION: Partial ejection (PE) of the upper extremity (UE) can occur in a motor vehicle crash (MVC) resulting in complex and severe soft tissue injuries (SSTI). This study evaluated the relationship between partial ejection and UE injuries, notably SSTIs, in MVCs focusing on crash types and characteristics, and further examined the role of side curtain airbags (SCABs) in the prevention of partial ejection and reducing SSTI of the UE. METHODS: Weighted data was analyzed from the National Automotive Sampling System Crashworthiness Data System (NASS-CDS) from 1993 to 2012...
March 28, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28329590/concomitant-metastatic-cutaneous-tuberculous-abscesses-and-pott-disease-in-an-immunocompetent-patient
#8
Ana Marcos-Pinto, Tiago Marques, António Pedro Machado, Luís Soares-de-Almeida, Paulo Filipe
Tuberculosis affects one-third of the world's population. The incidence of extrapulmonary tuberculosis including cutaneous and skeletal manifestations has increased in the last decades. The authors report a clinical case of concomitant metastatic cutaneous abscesses and Pott disease in an immunocompetent patient, a rare presentation of tuberculosis.
October 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28319754/association-between-harm-reduction-intervention-uptake-and-skin-and-soft-tissue-infections-among-people-who-inject-drugs
#9
Karen Dunleavy, Alison Munro, Kirsty Roy, Sharon Hutchinson, Norah Palmateer, Tony Knox, David Goldberg, Avril Taylor
BACKGROUND: Bacterial skin and soft tissue infections (SSTIs) are a health issue for people who inject drugs (PWID). There is a lack of evidence on the associations between harm reduction (HR) uptake and SSTIs. This paper examines the associations between the uptake of injecting equipment (IE) and opiate substitution treatment (OST) on SSTIs among PWID, and the injecting behaviours associated with having had an SSTI. This is the first large-scale, national study to examine the association between IE uptake and SSTIs...
March 6, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28261635/association-of-serum-lipids-and-coronary-artery-disease-with-polymorphisms-in-the-apolipoprotein-ai-ciii-aiv-gene-cluster
#10
Himanshu Rai, Nakul Sinha, James Finn, Suraksha Agrawal, Sarabjit Mastana
Genetic variants are considered as one of the main determinants of the concentration of serum lipids and coronary artery disease (CAD). Polymorphisms in the Apolipoprotein (Apo) AI-CIII-AIV gene cluster has been known to affect the concentrations of various lipid sub-fractions and the risk of CAD. The present study assessed associations between polymorphisms of the Apo AI-CIII-AIV gene cluster, [ApoA-I,-75G > A, (rs1799837); ApoC-III 3238C > G, (SstI), (rs5128) and ApoA-IV, Thr347Ser(347A > T), (rs675)] with serum lipids and their contributions to CAD in North Indian population...
December 31, 2016: Cogent Medicine
https://www.readbyqxmd.com/read/28255603/intraoperative-diagnosis-of-staphylococcus-aureus-and-coagulase-negative-staphylococcus-using-xpert-mrsa-sa-ssti-assay-in-prosthetic-joint-infection
#11
Andrea Sambri, Giovanni Pignatti, Matteo Romagnoli, Davide Donati, Maurilio Marcacci, Matteo Cadossi
The aim of this prospective study was to evaluate the performance of the Polymerase Chain Reaction (PCR) tool Xpert MRSA/SA SSTI test (Cepheid, Sunnyvale, CA, USA) on periprosthetic samples from a cohort of patients with suspected prosthetic joint infection (PJI). Seventy adult patients were included in this prospective study. On the basis of the preoperative evaluation, 39 patients were clinically considered to have a PJI, whereas 31 were presumed to suffer from an aseptic mobilization of the implant. Xpert MRSA/SA SSTI identified 4 out of 4 MRSA, 7 out of 7 MSSA, and 14 out of 16 methicillin resistant CoNS...
March 1, 2017: New Microbiologica
https://www.readbyqxmd.com/read/28250859/-18-f-fdg-pet-ct-for-the-diagnosis-of-malignant-and-infectious-complications-after-solid-organ-transplantation
#12
Nastassja Muller, Romain Kessler, Sophie Caillard, Eric Epailly, Fabrice Hubelé, Céline Heimburger, Izzie-Jacques Namer, Raoul Herbrecht, Cyrille Blondet, Alessio Imperiale
PURPOSE: Infection and malignancy represent two common complications after solid organ transplantation, which are often characterized by poorly specific clinical symptomatology. Herein, we have evaluated the role of (18)F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography/computed tomography (PET/CT) in this clinical setting. METHODS: Fifty-eight consecutive patients who underwent FDG PET/CT after kidney, lung or heart transplantation were included in this retrospective analysis...
March 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28246361/new-mouse-model-for-chronic-infections-by-gram-negative-bacteria-enabling-the-study-of-anti-infective-efficacy-and-host-microbe-interactions
#13
Daniel Pletzer, Sarah C Mansour, Kelli Wuerth, Negin Rahanjam, Robert E W Hancock
Only a few, relatively cumbersome animal models enable long-term Gram-negative bacterial infections that mimic human situations, where untreated infections can last for weeks. Here, we describe a simple murine cutaneous abscess model that enables chronic or progressive infections, depending on the subcutaneously injected bacterial strain. In this model, Pseudomonas aeruginosa cystic fibrosis epidemic isolate LESB58 caused localized high-density skin and soft tissue infections and necrotic skin lesions for up to 10 days but did not disseminate in either CD-1 or C57BL/6 mice...
February 28, 2017: MBio
https://www.readbyqxmd.com/read/28210352/risk-of-skin-and-soft-tissue-infections-among-children-found-to-be-staphylococcus-aureus-mrsa-usa300-carriers
#14
Lilly Cheng Immergluck, Shabnam Jain, Susan M Ray, Robert Mayberry, Sarah Satola, Trisha Chan Parker, Keming Yuan, Anaam Mohammed, Robert C Jerris
INTRODUCTION: The purpose of this study was to examine community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) carriage and infections and determine risk factors associated specifically with MRSA USA300. METHODS: We conducted a case control study in a pediatric emergency department. Nasal and axillary swabs were collected, and participants were interviewed for risk factors. The primary outcome was the proportion of S. aureus carriers among those presenting with and without a skin and soft tissue infection (SSTI)...
February 2017: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28162873/comparison-of-loop-and-primary-incision-drainage-techniques-in-adult-patients-with-cutaneous-abscess-a-preliminary-randomized-clinical-trial
#15
İbrahim Ulaş Özturan, Nurettin Özgür Doğan, Onur Karakayalı, Asım Enes Özbek, Serkan Yılmaz, Murat Pekdemir, Selim Suner
OBJECTIVES: The aim of this study is to compare efficacy of loop drainage and standard incision & drainage (I&D) in adult patients with cutaneous abscess in the emergency department. METHODS: This study is an interventional, parallel group, randomized clinical trial. Adult patients with cutaneous abscess were randomized into loop drainage and standard I&D groups. The primary outcome was defined as change in diameter of abscess and cellulitis 7days after procedure...
January 22, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28073795/in-patients-presenting-to-the-emergency-department-with-skin-and-soft-tissue-infections-what-is-the-diagnostic-accuracy-of-point-of-care-ultrasonography-for-the-diagnosis-of-abscess-compared-to-the-current-standard-of-care-a-systematic-review-and-meta-analysis
#16
David Barbic, Jordan Chenkin, Dennis D Cho, Tomislav Jelic, Frank X Scheuermeyer
OBJECTIVES: The primary objective of this systematic review was to determine the accuracy of point-of-care ultrasonography (POCUS) in diagnosing abscess in emergency department (ED) patients with skin and soft tissue infections (SSTI). The secondary objective was the accuracy of POCUS in the paediatric population subgroup. SETTING: Prospective studies set in emergency departments. PARTICIPANTS: Emergency department patients (adult and paediatric) presenting with SSTI and suspected abscess...
January 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28055287/epidemiology-treatment-and-economics-of-patients-presenting-to-the-emergency-department-for-skin-and-soft-tissue-infections
#17
Kristin E Linder, David P Nicolau, Michael D Nailor
OBJECTIVES: Skin and soft tissue infections (SSTIs) are among the most common bacterial diseases and represent a significant disease burden. The purpose of this study was to describe the real-world management of patients with SSTIs presenting to the emergency department (ED). METHODS: This is a retrospective cohort study. Adult patients identified with a primary diagnosis of SSTI determined by ICD-9 codes were assessed from index presentation for up to 30 days...
February 2017: Hospital Practice (Minneapolis)
https://www.readbyqxmd.com/read/28052529/successful-salvage-and-reconstruction-of-a-finger-threatened-by-vibrio-vulnificus-necrotising-fasciitis-using-fenestrated-type-artificial-dermis-and-three-steps-of-topical-negative-pressure-wound-therapy
#18
Chi-Yu Wang, Hao-Yu Chiao, Chang-Yi Chou, Chien-Ju Wu, Chun-Kai Chang, Tzi-Shiang Chu, Niann-Tzyy Dai
Vibrio vulnificus can cause severe skin and soft tissue infection (SSTI). The pathogen is an opportunistic marine bacterium that is likely to infect patients with chronic liver disease, patients in an immunocompromised state, and those in end-stage renal disease. V. vulnificus gains entry through soft tissues by direct penetration of a wound by infected marine organisms, such as raw oysters, shellfish and other seafood, or by exposing a wound to contaminated water. Despite its ease of entry, V. vulnificus necrotising fasciitis with compartment syndrome has rarely been described...
January 4, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28031850/isolated-mycobacterium-kansasii-wound-infection-and-osteomyelitis-in-an-immunocompetent-patient
#19
Tarek Turk, Mohamed Faher Almahmoud, Khulood Raslan
Mycobacterium kansasii is a slow growing acid-fast non-tuberculosis mycobacterium. It most commonly causes pulmonary disease with tuberculosis-like manifestations. Mycobacterium kansasii-induced skin and soft tissue infections (SSTIs) are very uncommon, especially in the absence of obvious risk factors. In this report, we present a rare case of M. kansasii-associated SSTI complicated by tendonitis and osteomyelitis in an immunocompetent patient. This case highlights the importance of considering non-tuberculosis mycobacteria while investigating chronic, relapsing, non-healing SSTIs and osteomyelitis...
November 2016: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/28029490/factors-influencing-drainage-setting-and-cost-for-cutaneous-abscesses-among-pediatric-patients
#20
COMPARATIVE STUDY
Corrie E Chumpitazi, Chris A Rees, Elizabeth A Camp, Karina L Valdez, Benjamin Choi, Bruno P Chumpitazi, Faria Pereira
OBJECTIVE: To evaluate the clinical and microbiological factors associated with skin and soft tissue infections drained in the emergency department (ED) vs operative drainage (OD) in a tertiary care children's hospital. METHODS: This was a cross-sectional study among children aged 2 months to 17 years who required incision and drainage (I&D). Demographic information, signs and symptoms, abscess size and location, and wound culture/susceptibility were recorded. Patient-specific charges were collected from the billing database...
February 2017: American Journal of Emergency Medicine
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