keyword
MENU ▼
Read by QxMD icon Read
search

Placenta choline

keyword
https://www.readbyqxmd.com/read/29667177/adverse-placental-effects-of-valproic-acid-studies-in-perfused-human-placentas
#1
Miriam Rubinchik-Stern, Miriam Shmuel, Jacob Bar, Michal Kovo, Sara Eyal
OBJECTIVE: In utero exposure to valproic acid (VPA) has been associated with worse pregnancy outcomes compared to all other antiepileptic drugs. We have previously shown that VPA alters the expression of placental transporters for hormones and nutrients in vitro and in pregnant mice. Here, our aim was to characterize the effects of short exposure to VPA on the expression of carriers for compounds essential for fetal development in human placentas ex vivo, under controlled conditions...
April 17, 2018: Epilepsia
https://www.readbyqxmd.com/read/29611403/effect-of-placenta-derived-mesenchymal-stem-cells-in-a-dementia-rat-model-via-microglial-mediation-a-comparison-between-stem-cell-transplant-methods
#2
Jae Sung Cho, Jihyeon Lee, Da Un Jeong, Han Wool Kim, Won Seok Chang, Jisook Moon, Jin Woo Chang
PURPOSE: Loss of cholinergic neurons in the hippocampus is a hallmark of many dementias. Administration of stem cells as a therapeutic intervention for patients is under active investigation, but the optimal stem cell type and transplantation modality has not yet been established. In this study, we studied the therapeutic effects of human placenta-derived mesenchymal stem cells (pMSCs) in dementia rat model using either intracerebroventricular (ICV) or intravenous (IV) injections and analyzed their mechanisms of therapeutic action...
May 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29597262/maternal-choline-supplementation-during-normal-murine-pregnancy-alters-the-placental-epigenome-results-of-an-exploratory-study
#3
Sze Ting Cecilia Kwan, Julia H King, Jennifer K Grenier, Jian Yan, Xinyin Jiang, Mark S Roberson, Marie A Caudill
The placental epigenome regulates processes that affect placental and fetal development, and could be mediating some of the reported effects of maternal choline supplementation (MCS) on placental vascular development and nutrient delivery. As an extension of work previously conducted in pregnant mice, the current study sought to explore the effects of MCS on various epigenetic markers in the placenta. RNA and DNA were extracted from placentas collected on embryonic day 15.5 from pregnant mice fed a 1X or 4X choline diet, and were subjected to genome-wide sequencing procedures or mass-spectrometry-based assays to examine placental imprinted gene expression, DNA methylation patterns, and microRNA (miRNA) abundance...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29529267/a-crucial-role-for-maternal-dietary-methyl-donor-intake-in-epigenetic-programming-and-fetal-growth-outcomes
#4
Meghan McGee, Shannon Bainbridge, Bénédicte Fontaine-Bisson
The fetal origins of health and disease framework has identified extremes in fetal growth and birth weight as factors associated with the lifelong generation of chronic diseases such as obesity, diabetes, cardiovascular disease, and hypertension. Maternal nutrition plays a critical role in fetal and placental development, in part by providing the methyl groups required to establish the fetus's genome structure and function, notably through DNA methylation. The goal of this narrative review is to describe the role of maternal dietary methyl donor (methionine, folate, and choline) and cofactor (zinc and vitamins B2, B6, and B12) intake in one-carbon metabolism and DNA methylation in the fetus and placenta, as well as their impacts on fetal growth and lifelong health outcomes, with specific examples in animals and humans...
June 1, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29178045/considering-choline-as-methionine-precursor-lipoproteins-transporter-hepatic-promoter-and-antioxidant-agent-in-dairy-cows
#5
REVIEW
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Rab N Soomro, Mohamed E Abd El-Hack, Mervat A Abdel-Latif, Wen Li, Ren Hao, Feifei Sun, Bello M Bodinga, Khawar Hayat, Junhu Yao, Yangchun Cao
During the transition period, fatty liver syndrome may be caused in cows undergo negative energy balance, ketosis or hypocalcemia, retained placenta or mastitis problems. During the transition stage, movement of non-esterified fatty acids (NEFA) increases into blood which declines the hepatic metabolism or reproduction and consequently, lactation performance of dairy cows deteriorates. Most of studies documented that, choline is an essential nutrient which plays a key role to decrease fatty liver, NEFA proportion, improve synthesis of phosphatidylcholine, maintain lactation or physiological function and work as anti-oxidant in the transition period of dairy cows...
November 25, 2017: AMB Express
https://www.readbyqxmd.com/read/29122468/an-intronic-variation-in-slc52a1-causes-exon-skipping-and-transient-riboflavin-responsive-multiple-acyl-coa-dehydrogenation-deficiency
#6
Signe Mosegaard, Gitte Hoffmann Bruun, Karen Freund Flyvbjerg, Yngve Thomas Bliksrud, Niels Gregersen, Maja Dembic, Ellen Annexstad, Trine Tangeraas, Rikke Katrine Jentoft Olsen, Brage S Andresen
Vitamin B2, riboflavin is essential for cellular function, as it participates in a diversity of redox reactions central to human metabolism, through its role as precursor for the cofactors flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD), which are electron carriers. The electron transfer flavoprotein (ETF) and its dehydrogenase (ETFDH), uses FAD as cofactor. The ETF and ETFDH are forming the electron transport pathway for many mitochondrial flavoprotein dehydrogenases involved in fatty acid, amino acid and choline metabolism...
December 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28931587/maternal-choline-supplementation-modulates-placental-nutrient-transport-and-metabolism-in-late-gestation-of-mouse-pregnancy
#7
Sze Ting Cecilia Kwan, Julia H King, Jian Yan, Zhen Wang, Xinyin Jiang, Jason S Hutzler, Hallie R Klein, J Thomas Brenna, Mark S Roberson, Marie A Caudill
Background: Fetal growth is dependent on placental nutrient supply, which is influenced by placental perfusion and transporter abundance. Previous research indicates that adequate choline nutrition during pregnancy improves placental vascular development, supporting the hypothesis that choline may affect placental nutrient transport. Objective: The present study sought to determine the impact of maternal choline supplementation (MCS) on placental nutrient transporter abundance and nutrient metabolism during late gestation...
November 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28915389/choline-prevents-fetal-overgrowth-and-normalizes-placental-fatty-acid-and-glucose-metabolism-in-a-mouse-model-of-maternal-obesity
#8
Juha Nam, Esther Greenwald, Chauntelle Jack-Roberts, Tamara T Ajeeb, Olga V Malysheva, Marie A Caudill, Kathleen Axen, Anjana Saxena, Ekaterina Semernina, Khatia Nanobashvili, Xinyin Jiang
Maternal obesity increases placental transport of macronutrients, resulting in fetal overgrowth and obesity later in life. Choline participates in fatty acid metabolism, serves as a methyl donor and influences growth signaling, which may modify placental macronutrient homeostasis and affect fetal growth. Using a mouse model of maternal obesity, we assessed the effect of maternal choline supplementation on preventing fetal overgrowth and restoring placental macronutrient homeostasis. C57BL/6J mice were fed either a high-fat (HF, 60% kcal from fat) diet or a normal (NF, 10% kcal from fat) diet with a drinking supply of either 25 mM choline chloride or control purified water, respectively, beginning 4 weeks prior to mating until gestational day 12...
November 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28487022/maternal-choline-supplementation-during-murine-pregnancy-modulates-placental-markers-of-inflammation-apoptosis-and-vascularization-in-a-fetal-sex-dependent-manner
#9
Sze Ting Cecilia Kwan, Julia H King, Jian Yan, Xinyin Jiang, Emily Wei, Vladislav G Fomin, Mark S Roberson, Marie A Caudill
INTRODUCTION: Normal placental vascular development is influenced by inflammatory, angiogenic and apoptotic processes, which may be modulated by choline through its role in membrane biosynthesis, cellular signaling and gene expression regulation. The current study examined the effect of maternal choline supplementation (MCS) on placental inflammatory, angiogenic and apoptotic processes during murine pregnancy. METHOD: Pregnant dams were randomized to receive 1, 2 or 4 times (X) the normal choline content of rodent diets, and tissues were harvested on embryonic day (E) 10...
May 2017: Placenta
https://www.readbyqxmd.com/read/28436303/choline-supplementation-during-pregnancy-protects-against-gestational-lipopolysaccharide-induced-inflammatory-responses
#10
Min Zhang, Xinjia Han, Juejie Bao, Jinying Yang, Shao-Qing Shi, Robert E Garfield, Huishu Liu
OBJECTIVES: To estimate the effects and mechanisms of choline, an essential nutrient and a selective α7 nicotinic acetylcholine receptor (α7nAChR) agonist, on the prevention of symptoms and the effects on the cholinergic anti-inflammatory pathways (CAP) in a lipopolysaccharide (LPS)-induced inflammatory response in a rat model. METHODS: Inflammation was induced by LPS treatment (1.0 μg LPS/kg body weight) on gestational day (GD) 14. Nonpregnant and pregnant Sprague Dawley rats were placed on a normal choline diet (1...
January 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/28069796/high-dietary-folate-in-pregnant-mice-leads-to-pseudo-mthfr-deficiency-and-altered-methyl-metabolism-with-embryonic-growth-delay-and-short-term-memory-impairment-in-offspring
#11
Renata H Bahous, Nafisa M Jadavji, Liyuan Deng, Marta Cosín-Tomás, Jessica Lu, Olga Malysheva, Kit-Yi Leung, Ming-Kai Ho, Mercè Pallàs, Perla Kaliman, Nicholas D E Greene, Barry J Bedell, Marie A Caudill, Rima Rozen
Methylenetetrahydrofolate reductase (MTHFR) generates methyltetrahydrofolate for methylation reactions. Severe MTHFR deficiency results in homocystinuria and neurologic impairment. Mild MTHFR deficiency (677C > T polymorphism) increases risk for complex traits, including neuropsychiatric disorders. Although low dietary folate impacts brain development, recent concerns have focused on high folate intake following food fortification and increased vitamin use. Our goal was to determine whether high dietary folate during pregnancy affects brain development in murine offspring...
March 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28058480/everyman-s-prostate-phantom-kiwi-fruit-substitute-for-human-prostates-at-magnetic-resonance-imaging-diffusion-weighted-imaging-and-magnetic-resonance-spectroscopy
#12
Ullrich G Mueller-Lisse, Sophie Murer, Ulrike L Mueller-Lisse, Marissa Kuhn, Juergen Scheidler, Michael Scherr
OBJECTIVES: To apply an easy-to-assemble phantom substitute for human prostates in T2-weighted magnetic resonance imaging (T2WI), diffusion-weighted imaging (DWI) and 3D magnetic resonance spectroscopy (MRS). METHODS: Kiwi fruit were fixed with gel hot and cold compress packs on two plastic nursery pots, separated by a plastic plate, and submerged in tap water inside a 1-L open-spout plastic watering can for T2WI (TR/TE 7500/101 ms), DWI (5500/61 ms, ADC b50-800 s/mm2 map) and MRS (940/145 ms) at 3...
August 2017: European Radiology
https://www.readbyqxmd.com/read/27784933/gelatin-binding-proteins-in-reproductive-physiology
#13
REVIEW
Sanjay Kumar, Alex Tinson, Brendan Patrick Mulligan, Shreesh Ojha
In order to advance the assisted reproductive technologies used in animals and human beings, it is important to accumulate basic informations about underlying molecular mechanisms that shape the biological processes of reproduction. From within seminal plasma, proteins perform a wide variety of distinct functions that regulate major reproductive events such as fertilization. The ability of such proteins to bind and interact with different antagonistic ions and biomolecules such as polysaccharides, lipids, and other proteins present in the male and female reproductive tract define these capabilities...
December 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27707701/moderate-folic-acid-supplementation-and-mthfd1-synthetase-deficiency-in-mice-a-model-for-the-r653q-variant-result-in-embryonic-defects-and-abnormal-placental-development
#14
Karen E Christensen, Wenyang Hou, Renata H Bahous, Liyuan Deng, Olga V Malysheva, Erland Arning, Teodoro Bottiglieri, Marie A Caudill, Loydie A Jerome-Majewska, Rima Rozen
BACKGROUND: Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and fetus. Common polymorphisms in folate genes, such as methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase (MTHFD1) R653Q, may modulate the effects of elevated folic acid intake. OBJECTIVES: We investigated the effects of moderate folic acid supplementation on reproductive outcomes and assessed the potential interaction of the supplemented diet with MTHFD1-synthetase (Mthfd1S) deficiency in mice, which is a model for the R653Q variant...
November 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27647687/assessment-of-the-placenta-in-intrauterine-growth-restriction-by-diffusion-weighted-imaging-and-proton-magnetic-resonance-spectroscopy
#15
Fuzhen Song, Weibin Wu, Zhaoxia Qian, Guofu Zhang, Yingsheng Cheng
Placental insufficiency is a major cause of intrauterine growth restriction (IUGR) and seriously affects fetal development. When placental insufficiency happened, the diffusion of water molecule was restricted and the metabolic balance was destroyed in the placenta. In this prospective study, we aimed to evaluate the diagnostic value of diffusion-weighted imaging (DWI) in combination with proton magnetic resonance spectroscopy (1 H MRS) for placental insufficiency in IUGR. The apparent diffusion coefficient (ADC) values were calculated using DWI, and the metabolism of N-acetylaspartate (NAA), choline, and lipid and their ratios in the placenta were calculated using1 H MRS...
April 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/27638261/better-postpartal-performance-in-dairy-cows-supplemented-with-rumen-protected-methionine-compared-with-choline-during-the-peripartal-period
#16
RANDOMIZED CONTROLLED TRIAL
Z Zhou, M Vailati-Riboni, E Trevisi, J K Drackley, D N Luchini, J J Loor
The onset of lactation in dairy cows is characterized by high output of methylated compounds in milk when sources of methyl group are in short supply. Methionine and choline (CHOL) are key methyl donors and their availability during this time may be limiting for milk production, hepatic lipid metabolism, and immune function. Supplementing rumen-protected Met and CHOL may improve overall performance and health of transition cows. The objective of this study was to evaluate the effect of supplemental rumen-protected Met and CHOL on performance and health of transition cows...
November 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/27444754/knocking-down-of-heat-shock-protein-27-directs-differentiation-of-functional-glutamatergic-neurons-from-placenta-derived-multipotent-cells
#17
Yu-Che Cheng, Chi-Jung Huang, Yih-Jing Lee, Lu-Tai Tien, Wei-Chi Ku, Raymond Chien, Fa-Kung Lee, Chih-Cheng Chien
This study presents human placenta-derived multipotent cells (PDMCs) as a source from which functional glutamatergic neurons can be derived. We found that the small heat-shock protein 27 (HSP27) was downregulated during the neuronal differentiation process. The in vivo temporal and spatial profiles of HSP27 expression were determined and showed inverted distributions with neuronal proteins during mouse embryonic development. Overexpression of HSP27 in stem cells led to the arrest of neuronal differentiation; however, the knockdown of HSP27 yielded a substantially enhanced ability of PDMCs to differentiate into neurons...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27335139/vitamin-d-metabolism-varies-among-women-in-different-reproductive-states-consuming-the-same-intakes-of-vitamin-d-and-related-nutrients
#18
RANDOMIZED CONTROLLED TRIAL
Heyjun Park, Patsy M Brannon, Allyson A West, Jian Yan, Xinyin Jiang, Cydne A Perry, Olga V Malysheva, Saurabh Mehta, Marie A Caudill
BACKGROUND: The impact of the reproductive state on vitamin D metabolism and requirements is uncertain in part because of a lack of studies with controlled dietary intakes of vitamin D and related nutrients. OBJECTIVE: We aimed to quantify the impact of the reproductive state on a panel of vitamin D biomarkers among women of childbearing age consuming equivalent amounts of vitamin D and related nutrients. METHODS: Nested within a feeding study providing 2 doses of choline, healthy pregnant (26-29 wk gestation; n = 26), lactating (5 wk postpartum; n = 28), and control (nonpregnant/nonlactating; n = 21) women consumed a single amount of vitamin D (511 ± 48 IU/d: 311 ± 48 IU/d from diet and 200 IU/d as supplemental cholecalciferol) and related nutrients (1...
August 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27081315/effects-of-choline-on-dna-methylation-and-macronutrient-metabolic-gene-expression-in-in-vitro-models-of-hyperglycemia
#19
Xinyin Jiang, Esther Greenwald, Chauntelle Jack-Roberts
Choline is an essential nutrient that plays an important role in lipid metabolism and DNA methylation. Studies in rodents suggest that choline may adversely affect glycemic control, yet studies in humans are lacking. Using the human hepatic and placental cells, HepG2 and BeWo, respectively, we examined the interaction between choline and glucose treatments. In HepG2 cells, choline supplementation (1 mM) increased global DNA methylation and DNA methyltransferase expression in both low-glucose (5 mM) and high-glucose (35 mM) conditions...
2016: Nutrition and Metabolic Insights
https://www.readbyqxmd.com/read/27070784/metabolomics-of-human-amniotic-fluid-and-maternal-plasma-during-normal-pregnancy
#20
Magdalena Orczyk-Pawilowicz, Ewa Jawien, Stanislaw Deja, Lidia Hirnle, Adam Zabek, Piotr Mlynarz
Metabolic profiles of amniotic fluid and maternal blood are sources of valuable information about fetus development and can be potentially useful in diagnosis of pregnancy disorders. In this study, we applied 1H NMR-based metabolic profiling to track metabolic changes occurring in amniotic fluid (AF) and plasma (PL) of healthy mothers over the course of pregnancy. AF and PL samples were collected in the 2nd (T2) and 3rd (T3) trimester, prolonged pregnancy (PP) until time of delivery (TD). A multivariate data analysis of both biofluids reviled a metabolic switch-like transition between 2nd and 3rd trimester, which was followed by metabolic stabilization throughout the rest of pregnancy probably reflecting the stabilization of fetal maturation and development...
2016: PloS One
keyword
keyword
83292
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"