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https://www.readbyqxmd.com/read/29044908/tumor-radiomic-heterogeneity-multiparametric-functional-imaging-to-characterize-variability-and-predict-response-following-cervical-cancer-radiation-therapy
#1
Stephen R Bowen, William T C Yuh, Daniel S Hippe, Wei Wu, Savannah C Partridge, Saba Elias, Guang Jia, Zhibin Huang, George A Sandison, Dennis Nelson, Michael V Knopp, Simon S Lo, Paul E Kinahan, Nina A Mayr
BACKGROUND: Robust approaches to quantify tumor heterogeneity are needed to provide early decision support for precise individualized therapy. PURPOSE: To conduct a technical exploration of longitudinal changes in tumor heterogeneity patterns on dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted imaging (DWI) and FDG positron emission tomography / computed tomography (PET/CT), and their association to radiation therapy (RT) response in cervical cancer...
October 16, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29042795/significant-association-of-the-exo1-rs851797-polymorphism-with-clinical-outcome-of-ovarian-cancer
#2
Tingyan Shi, Rong Jiang, Pan Wang, Yuan Xu, Sheng Yin, Xi Cheng, Rongyu Zang
BACKGROUND: Exonuclease 1 (EXO1), one of DNA mismatch repair pathway genes, functions in maintaining genomic stability and affects tumor progression. We hypothesized that genetic variations in EXO1 may predict clinical outcomes in epithelial ovarian cancer (EOC). METHODS: In this cohort study with 1,030 consecutive EOC patients, we genotyped four potentially functional polymorphisms in EXO1 by the Taqman assay and evaluated their associations with patients' survival...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29039544/formyl-peptide-receptor%C3%A2-2-expression-predicts-poor-prognosis-and-promotes-invasion-and-metastasis-in-epithelial-ovarian-cancer
#3
Xiaohui Xie, Mengyuan Yang, Yiling Ding, Ling Yu, Jianlin Chen
Formyl peptide receptor 2 (FPR2) has been identified as a member of the G protein-coupled chemoattractant receptor (GPCR) family and has been implicated as playing a role in both inflammation and cancer development. Epithelial ovarian cancer (EOC) has been suggested to be correlated with both infectious and non-infectious inflammation. To date, the role of FPR2 in EOC remains poorly understood and controversial. In the present study, we aimed to investigate the potential of FPR2 in regulating EOC. We performed immunohistochemistry and RT-qPCR to analyzed expression of FPR2 in EOC tissues and the correlation between FPR2 and EOC clinicopathological characteristics as well as prognosis were also analyzed...
October 13, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29039491/non-canonical-hedgehog-signaling-activation-in-ovarian-borderline-tumors-and-ovarian-carcinomas
#4
Petar Ozretić, Diana Trnski, Vesna Musani, Ivana Maurac, Držislav Kalafatić, Slavko Orešković, Sonja Levanat, Maja Sabol
Hedgehog signaling pathway has been implicated in the pathology of ovarian cancer, and Survivin (BIRC5) has been suggested as a novel target of this pathway. Herein we investigated the role of Hedgehog signaling pathway and Survivin in ovarian carcinoma and borderline tumor samples. We aimed to determine possible ways of pathway modulation on primary ovarian cancer cells and an established cell line. RNA was extracted from fresh tumors and control tissues and gene expression was examined using qRT-PCR. Pathway activity in cell lines was examined after treatment with cyclopamine, SHH protein, GANT-61 or lithium chloride using qRT-PCR, western blot and confocal microscopy...
October 12, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29036787/evaluation-of-serum-ccl18-as-a-potential-biomarker-for-ovarian-cancer
#5
Linjing Yuan, Jianxin Wan, Chumei Huang, Jingjing Liang, Min Liu, Caifeng Yue, Laisheng Li
BACKGROUND: Early detection and differentiation diagnosis of a pelvic mass (PM) is crucial in improving the prognosis of patients with epithelial ovarian cancer (EOC). C-C motif chemokine ligand 18 (CCL18) was reported as a chemokine-mediated tumor-related inflammation that can be detected in serum and may correlate with cancer patients' prognosis. OBJECTIVE: We performed this study to investigate the relationship between CCL18 levels and clinical characteristics of EOC patients, and to explore their diagnostic and prognostic values...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29032160/multimodal-treatment-including-hysterectomy-improves-survival-in-patients-with-locally-advanced-cervical-cancer-a-population-based-propensity-score-matched-analysis
#6
San-Gang Wu, Wen-Wen Zhang, Jia-Yuan Sun, Feng-Yan Li, Zhen-Yu He, Juan Zhou
BACKGROUND: To evaluate the therapeutic value of multimodal treatment including hysterectomy in locally advanced cervical squamous cell carcinoma (SCC). METHODS: We retrospectively reviewed patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stage IIB-III cervical SCC between 2000 and 2013 using the Surveillance, Epidemiology, and End Results (SEER) program. Propensity score-matching was used to balance baseline characteristics of included patients...
October 12, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29028098/down-regulation-of-mir-329-3p-is-associated-with-worse-prognosis-in-patients-with-cervical-cancer
#7
Y-H Chang, F Yin, G-F Fan, M Zhao
OBJECTIVE: miR-329-3p has been reported to serve as a tumor suppressor in the progression of cervical cancer (CC). The aim of this study was to investigate the clinical significance of miR-329-3p in human CC. PATIENTS AND METHODS: Quantitative RT-PCR (qRT-PCR) was used to detect miR-329-3p expression in CC tissue samples and matched normal cervical tissues. The x2 test was used to analyze the association between miR-329-3p expression and clinical features of CC patients...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29027399/early-stage-node-negative-cervical-adenocarcinoma-and-squamous-cell-carcinoma-show-similar-survival-outcomes-after-hysterectomy-a-population-based-study
#8
San Gang Wu, Jia Yuan Sun, Zhen Yu He, Qiong Hua Chen, Juan Zhou
OBJECTIVE: To investigate the clinicopathological features and outcomes between node-negative, early-stage cervical squamous cell carcinoma (SCC) and adenocarcinoma (AC) after hysterectomy. METHODS: Patients diagnosed with International Federation of Gynecology and Obstetrics (FIGO) stages I-IIA cervical SCC and AC between 1988 and 2013 were retrospectively reviewed using the Surveillance, Epidemiology, and End Results database. We used propensity score-matching to balance patient baseline characteristics...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027393/down-regulated-serum-microrna-101-is-associated-with-aggressive-progression-and-poor-prognosis-of-cervical-cancer
#9
Wei Jiang, Jia Jia Pan, Ying Hui Deng, Mei Rong Liang, Li Hua Yao
OBJECTIVE: MicroRNAs (miRNAs) play a vital role in pathogenesis and progression of many cancers, including cervical cancer. However, importance of serum level of miR-101 in cervical cancer has rarely been studied. In the present study, clinical significance and prognostic value of serum miR-101 for cervical cancer was investigated. METHODS: Association between miR-101 level in cervical cancer tissues and prognosis of patients was analyzed by using data retrieved from The Cancer Genome Atlas (TCGA) database, which was followed with our clinical study in which miR-101 serum level comparison between cervical cancer patients and healthy controls was conducted by real-time quantitative polymerase chain reaction (PCR)...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29017822/sub-optimal-primary-surgery-leads-to-unfavorable-immunological-changes-in-ovarian-cancer-patients
#10
Marek Nowak, Ewa Głowacka, Przemysław Lewkowicz, Małgorzata Banasik, Krzysztof Szyłło, Kinga Zimna, Katarzyna Bednarska, Magdalena Klink
Primary cytoreduction, followed by chemotherapy, is a standard treatment of patients with epithelial ovarian cancer (EOC). However, the effectiveness of this treatment depend on various elements e.g. type of operation. It is accepted that optimal surgery correlates with longer survival of patients. The other element, an efficiency of immune system after surgical intervention although important is less elucidated. The aim of this study was to establish the impact of optimal and sub-optimal operation on immunological status of EOC patients regarding also their overall survival (OS)...
October 5, 2017: Immunobiology
https://www.readbyqxmd.com/read/28993225/treatment-approach-and-prognosis-of-pediatric-and-adolescent-non-epithelial-malignant-ovarian-tumors-a-retrospective-prognosis-analysis
#11
Peili Liang, Xin Zhang, Zhenfeng Zhang, Guocai Xu, Xingsu Yu, Sijin Li, Yuanyuan Zhang, Lijuan Bian, Bingzhong Zhang
BACKGROUND: Non-epithelial malignant ovarian tumors are rare in the pediatric and adolescent population. AIM: To observe the spectrum of pathology, presentation, outcome, and risk factors for survival of pediatric non-epithelial malignant ovarian tumors in a Chinese pediatric population. METHODS: This was a retrospective study of 171 girls (median age at presentation of 14 years) diagnosed with primary malignant ovarian tumors between 1990 and 2014 at the Yat-Sen Memorial Hospital and Cancer Center of Sun Yat-sen University...
October 6, 2017: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/28991928/clinical-significance-of-pretreatment-serum-levels-of-vegf-and-its-receptors-il-8-and-their-prognostic-value-in-type-i-and-ii-endometrial-cancer-patients
#12
Beata Kotowicz, Malgorzata Fuksiewicz, Joanna Jonska-Gmyrek, Alicja Berezowska, Jakub Radziszewski, Mariusz Bidzinski, Maria Kowalska
OBJECTIVES: The study aimed to assess the usefulness of the determination of cytokines: IL-8, VEGF and its soluble receptors: VEGF-R1, VEGF-R2 in patients with endometrial cancer (EC). MATERIAL/METHODS: The study group consisted of 118 patients with EC subjected to surgical treatment. Before the treatment we determined the serum levels of cytokines IL-8, and VEGF as well as VEGFR1 and VEGFR2 receptors. For comparison, the concentration of CA 125 was also measured...
2017: PloS One
https://www.readbyqxmd.com/read/28990139/association-between-morphological-patterns-of-myometrial-invasion-and-cancer-stem-cell-markers-in-endometrial-endometrioid-carcinoma
#13
Ji Y Park, Daegy Hong, Ji Young Park
In endometrial endometrioid adenocarcinoma (EEC), the depth of myometrial invasion (MI) is an important parameter for determining whether additional treatment is warranted. The present study investigated the association between MI patterns, cancer stem cell (CSC) phenotypes, and their clinicopathological significance in EEC. A total of 73 cases of EEC with MI were examined in this study. Haematoxylin and eosin-stained tissue specimens were analysed for MI pattern, which was categorised as infiltrating; expansile; adenomyosis (AM)-like; or microcystic, elongated, and fragmented (MELF)-type...
October 8, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28988254/preoperative-thrombocytosis-as-a-prognostic-factor-in-endometrioid-type-endometrial-carcinoma
#14
Ahmed Abu-Zaid, Mohannad Alsabban, Mohammed Abuzaid, Osama AlOmar, Hany Salem, Ismail A Al-Badawi
BACKGROUND: The impact of preoperative thrombocytosis as a prognostic factor in endometrial carcinoma (EC) remains uncertain and has never been examined in Saudi Arabia. OBJECTIVES: To determine the prevalence of preoperative thrombocytosis (platelet count > 400 000/ μL), and its prognostic significance for clinicopathological factors and survival in Saudi patients with endometrioid-type EC. DESIGN: A retrospective cross-sectional study from January 2010 to December 2013...
September 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28984338/synchronous-cervical-minimal-deviation-adenocarcinoma-gastric-type-adenocarcinoma-and-lobular-endocervical-glandular-hyperplasia-along-with-stil-in-peutz-jeghers-syndrome-eliciting-oncogenesis-pathways
#15
Azfar Neyaz, Nuzhat Husain, Manish Deodhar, Rohini Khurana, Saumya Shukla, Aditi Arora
We describe an unusual case of a Peutz-Jeghers syndrome associated with a composite synchronous cervical neoplasia comprising precursor "lobular endocervical glandular hyperplasia (LEGH)", "minimal deviation adenocarcinoma (MDA)" and "gastric-type adenocarcinoma (GTA)" along with a serous tubal intraepithelial lesion (STIL) in the right fallopian tube. A 24-year-old woman presented with a white mucoid discharge and bleeding per vaginum for one year. Histopathological evaluation showed MDA & GTA in FIGO grade III with pelvic lymph node metastasis despite a deceptively bland tumour morphology and low Ki-67 index, indicating an aggressive tumour course and poor prognosis...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28983164/extensively-metastasizing-leiomyosarcoma-a-diagnostic-challenge
#16
Arvind Ahuja, Poojan Agarwal, Rohan Sardana, Suryanarayanan Bhaskar
Uterine leiomyosarcoma (ULMS) is a rare malignancy of the female genital tract and carries an extremely poor 5-year survival rate. It is known to metastasize early and to distant sites owing to a high propensity for hematogeneous spread. Lung, peritoneum, liver, and bone are relatively common sites of metastasis. Patient age, tumor size, FIGO stage, and grade of the tumor are important criteria for predicting metastasis. The incidence of ULMS is increasing, probably due to the use of improved imaging techniques and as a result of cancer patients' prolonged life expectancy...
July 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/28982877/the-impact-of-surgical-staging-on-the-prognosis-of-mucinous-borderline-tumors-of-the-ovaries-a-multicenter-study
#17
MULTICENTER STUDY
Kemal Gungorduk, Osman Asicioglu, Elena Ioana Braicu, Jumana Almuheimid, Sevki Goksun Gokulu, Nilufer Cetinkaya, Tayfun Gungor, Gonca Pakay, Elcin Uzmez Telli, Zeliha Firat Cuylan, Tayfun Toptas, Ahmet Bilgi, Ramazan Ozyurt, Elif Agacayak, Aykut Ozdemir, Nuri Yildirim, Salih Taskin, Tufan Oge, Onur Erol, Levent Akman, Anil Turan, Mehmet Sait Icen, Taylan Senol, Ozlem Irak Ovali, Burcu Yucesoy, Ozgu Gungorduk, Osman Temizkan, Muzaffer Sanci, Tayup Simsek, Mehmet Mutlu Meydanli, Mehmet Harma, Levent Yasar, Aysel Derbent Uysal, Ates Karateke, Firat Ortac, Sabit Sinan Ozalp, Jalid Sehouli, Mustafa Zelal Muallem
BACKGROUND/AIM: The purpose of this study was to prove the effect of complete surgical staging of patients with mucinous borderline ovarian tumors (mBOTs) especially appendectomy on progression-free survival (PFS) and overall survival (OS). PATIENTS AND METHODS: The database of 14 gynecological oncology departments from Turkey and Germany were comprehensively searched for women who underwent primary surgery for an ovarian tumor between January 1, 1998, and December 31, 2015, and whose final diagnosis was mBOT...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28981739/phase-iii-trial-to-confirm-the-superiority-of-pelvic-and-para-aortic-lymphadenectomy-to-pelvic-lymphadenectomy-alone-for-endometrial-cancer-japan-clinical-oncology-group-study-1412-sepal-p3
#18
Hidemichi Watari, Hiroshi Katayama, Taro Shibata, Kimio Ushijima, Toyomi Satoh, Takashi Onda, Daisuke Aoki, Haruhiko Fukuda, Nobuo Yaegashi, Noriaki Sakuragi
To prospectively investigate the survival benefit of para-aortic lymphadenectomy, we launched a new study, the JCOG1412. This is a randomized Phase III trial to confirm the superiority of pelvic and para-aortic lymphadenectomy to pelvic lymphadenectomy alone. Patients corresponding to possible FIGO Stage IB, II, IIIA, IIIB, and a part of IIIC1 are eligible for the first registration before surgery. Next, those patients without evidence of para-aortic lymph node metastasis and multiple pelvic lymph node metastasis during surgery will be included in the second registration and randomized to either the pelvic lymphadenectomy alone arm or the pelvic and para-aortic lymphadenectomy arm...
October 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28980832/figo-s-response-to-the-global-challenge-of-hyperglycemia-in-pregnancy-toward-a-global-consensus
#19
Anil Kapur, Tahir Mahmood, Moshe Hod
No abstract text is available yet for this article.
October 5, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28978897/serum-ca-125-level-after-neoadjuvant-chemotherapy-is-predictive-of-prognosis-and-debulking-surgery-outcomes-in-advanced-epithelial-ovarian-cancer
#20
Tomohiko Matsuhashi, Toshiyuki Takeshita, Akihito Yamamoto, Rieko Kawase, Takashi Yamada, Keisuke Kurose, Daisuke Doi, Katsuyuki Konnai, Ryo Onose, Hisamori Kato
Recently, neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS) has been recommended for selected patients with International Federation of Gynecology and Obstetrics (FIGO) stage III or IV disease and bulky tumors. The aim of this study was to evaluate associations between post-NACT serum CA 125 levels, surgical outcomes, and clinical outcomes in patients with advanced epithelial ovarian cancer. We retrospectively analyzed 107 patients with FIGO stage III or IV ovarian cancer who were treated with NACT-IDS at the Gynecology Department of Kanagawa Cancer Center between January 2001 and December 2012...
2017: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
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