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https://www.readbyqxmd.com/read/27922289/assessing-the-risk-of-clinical-and-pathologic-factors-for-relapse-of-borderline-ovarian-tumours
#1
Chung Chang, Jiabin Chen, Wei-An Chen, Szu-Pei Ho, Wen Shiung Liou, An Jen Chiang
The objective of this study was to identify clinical and pathologic factors that are significant to relapse in borderline ovarian tumours (BOT). All patients with BOTs from 1997 to 2012 in our institute were identified. 115 patients were included in the study. The Cox proportional hazards model was used to identify significant factors. The median age was 42 years (range 14-85 years). The majority of the patients were at FIGO stage I (88.7%), and most of the patients had mucinous histology (66.1%), reflecting the predominant distribution of mucinous BOTs in East Asia...
December 6, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/27916168/preoperative-diagnosis-of-tumor-grade-and-type-in-endometrial-cancer-by-pipelle-sampling-and-hysteroscopy-results-of-a-french-study
#2
REVIEW
Juliette Phelippeau, Geoffroy Canlorbe, Sofiane Bendifallah, Iptissem Naoura, Marine Lefevre, Marcos Ballester, Emile Daraï
BACKGROUND: No data are available to establish whether operative hysteroscopy is superior to standard pipelle sampling to determine histological and grade status in endometrial cancer (EC). The aim of this study was to evaluate whether pipelle device sampling or operative hysteroscopy had an impact on preoperative determination of histological and grade status in EC and consequently on surgical management. METHODS: Data of 224 women with EC receiving primary surgical treatment between 2002 and 2014 were abstracted from a single institution with maintained database...
December 2016: Surgical Oncology
https://www.readbyqxmd.com/read/27916063/-clinical-application-of-adult-comorbidity-evaluation-27-in-endometrial-cancer
#3
W Y Tian, Y M Wang, Y Yan, J P Gao, D D Sun, S Jiang, Y Sheng, F Teng, F X Xue
Objective: To investigate the significant role of the clinical application of adult comorbidity evaluation-27 (ACE-27) in endometrial cancer (EC). Methods: A total of 847 EC patients were included during Jan. 1985 to Dec. 2015 from Tianjin Medical University General Hospital. The clinical data of the patients were collected and analyzed retrospectively. All of the patients were received operation with no chemotherapy and radiotherapy before operation. The average age was 57.6 years old (range from 25 to 85 years old)...
November 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27914244/surgical-treatment-and-histopathological-assessment-of-advanced-cervicovaginal-carcinoma-a-prospective-study-and-retrospective-analysis
#4
Michael Höckel, Benjamin Wolf, Bettina Hentschel, Lars-Christian Horn
BACKGROUND: Standard treatment of advanced cervicovaginal cancer [international federation of gynecology and obstetrics (FIGO) stages II(B), III(A, B), IVA] is (chemo-)radiation excluding the possibility of systematic histopathological assessment of locoregional tumour spread. Laterally extended endopelvic resection (LEER) and therapeutic lymph node dissection (tLND) are novel surgical treatment options for advanced cervicovaginal cancer. METHODS: The therapeutic efficacy of LEER for locally advanced primary and recurrent cervicovaginal cancer was reassessed by an update of the prospective observational trial at the University of Leipzig...
November 30, 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27900047/microrna-138-inhibits-proliferation-migration-and-invasion-through-targeting-htert-in-cervical-cancer
#5
Na Zhou, Dan Fei, Shan Zong, Mingyue Zhang, Ying Yue
A growing body of evidence suggests that microRNA-138 (miR-138) functions as a tumor suppressor, and is involved in tumor initiation, development and metastasis in certain types of human cancers. However, the function and underlying molecular mechanism of miR-138 in cervical cancer remains unclear. Therefore, the purpose of the present study was to investigate the clinical significance of miR-138 expression in cervical cancer, and to evaluate its role and underlying mechanisms in cervical cancer. The present study indicated that miR-138 expression was significantly downregulated in cervical cancer tissues and cell lines, and that the low miR-138 expression was negatively associated with advanced FIGO stage and lymph node metastasis (P<0...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899973/expression-patterns-of-maspin-and-mutant-p53-are-associated-with-the-development-of-gestational-trophoblastic-neoplasia
#6
Pengming Sun, Qibin Wu, Guanyu Ruan, Xiu Zheng, Yiyi Song, Jianfan Zhun, Lixiang Wu, Walter H Gotlieb
Gestational trophoblastic disease (GTD) is a group of conditions that originate from the abnormal proliferation of trophoblastic cells. GTDs encompass hydatidiform moles (HMs) and gestational trophoblastic neoplasia (GTN). GTNs are a group of malignant diseases that require chemotherapy, or more aggressive treatment. There is a requirement for more tumor markers to predict the development of GTN from HMs. The current study evaluated the expression of maspin and tumor protein p53 (p53) in GTD, and their role in predicting the development of GTN...
November 2016: Oncology Letters
https://www.readbyqxmd.com/read/27899255/long-non-coding-rna-anril-indicates-a-poor-prognosis-of-cervical-cancer-and-promotes-carcinogenesis-via-pi3k-akt-pathways
#7
Dongli Zhang, Guixia Sun, Hongxia Zhang, Jun Tian, Yanyun Li
Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are playing critical roles in tumorgenesis. LncRNA ANRIL has been reported to promote tumor progression in types of cancers. However, the expression and function of ANRIL in cervical cancer are still largely unclear. We measured the expression of ANRIL in cervical cancer tissues and cell lines and analyzed its association with clinicopathological features and prognosis. Loss-of-function experiments were used to identify the biological function of ANRIL...
November 26, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27898420/long-non-coding-rna-bancr-promotes-endometrial-cancer-cell-proliferation-and-invasion-by-regulating-mmp2-and-mmp1-via-erk-mapk-signaling-pathway
#8
Danni Wang, Danbo Wang, Ning Wang, Zaiqiu Long, Xuemei Ren
BACKGROUND/AIMS: Microarray screening had found BRAF-activated non-coding RNA (BANCR) was significantly upregulated in type 1 endometrial cancer (EC). This study aimed to assess the potential role of long non-coding RNA (lncRNA) BANCR in the pathogenesis and progression of type 1 EC. METHODS: Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to confirm the expression of BANCR in type 1 EC tissue, and analyze its clinical significance...
November 30, 2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27896515/outcome-after-sentinel-lymph-node-dissection-in-vulvar-cancer-a-subgroup-analysis-of-the-ago-care-1-study
#9
Rüdiger Klapdor, Peter Hillemanns, Linn Wölber, Julia Jückstock, Felix Hilpert, Nikolaus de Gregorio, Severine Iborra, Jalid Sehouli, Anika Habermann, Sophie Teresa Fürst, Hans Georg Strauß, Klaus Baumann, Falk Thiel, Alexander Mustea, Werner Meier, Philipp Harter, Pauline Wimberger, Lars Hanker, Barbara Schmalfeldt, Ulrich Canzler, Tanja Fehm, Alexander Luyten, Martin Hellriegel, Jens Kosse, Christoph Heiss, Peer Hantschmann, Peter Mallmann, Berno Tanner, Jacobus Pfisterer, Barbara Richter, Martin Jäger, Sven Mahner
PURPOSE: Analyzing the large patient cohort of the multicenter AGO-CaRE-1 study, we compared isolated sentinel lymph node dissection (SLND) with radical lymph node dissection (LND) of the groin in relation to recurrence rates and survival. METHODS: The AGO-CaRE-1 study retrospectively collected data on treatment patterns and follow-up of vulvar cancer patients [International Federation of Gynecology and Obstetrics (FIGO) stage ≥1B] treated at 29 gynecologic cancer centers between 1998 and 2008...
November 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27894164/preoperative-ca125-and-fibrinogen-in-patients-with-endometrial-cancer-a-risk-model-for-predicting-lymphovascular-space-invasion
#10
Xingchen Zhou, Husheng Wang, Xipeng Wang
OBJECTIVE: The aim of this study was to build a model to predict the risk of lymphovascular space invasion (LVSI) in women with endometrial cancer (EC). METHODS: From December 2010 to June 2013, 211 patients with EC undergoing surgery at Shanghai First Maternity and Infant Hospital were enrolled in this retrospective study. Those patients were divided into a positive LVSI group and a negative LVSI group. The clinical and pathological characteristics were compared between the two groups; logistic regression was used to explore risk factors associated with LVSI occurrence...
October 27, 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27890281/corrigendum-to-treatment-outcomes-in-patients-with-figo-stage-ib-iia-cervical-cancer-and-a-focally-disrupted-cervical-stromal-ring-on-magnetic-resonance-imaging-a-propensity-score-matching-study-gynecol-oncol-143-2016-77-82
#11
Tae-Wook Kong, Jung-Dong Lee, Joo-Hyuk Son, Jiheum Paek, Mison Chun, Suk-Joon Chang, Hee-Sug Ryu
No abstract text is available yet for this article.
November 24, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27888704/association-of-r156r-single-nucleotide-polymorphism-of-the-ercc2-gene-with-the-susceptibility-to-ovarian-cancer
#12
Hanna Romanowicz, Magdalena M Michalska, Dariusz Samulak, Jakub Malinowski, Tomasz Szaflik, Jan Bieńkiewicz, Beata Smolarz
AIM: The reported study was designed to explore associations between the ERCC2- R156R gene single nucleotide polymorphism (SNP) and the risk of ovarian cancer. MATERIAL AND METHODS: The R156R (C to A, rs238406) polymorphism of ERCC2 gene was investigated by the PCR-RFLP technique in 400 patients with ovarian carcinoma and 400 age- and sex matched non-cancer controls. Blood samples were obtained from patients treated at the Department of Surgical Gynaecology and Gynaecologic Oncology, Institute of Polish Mothers Memorial Hospital between the years 2000 and 2015...
November 15, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27887627/epha5-protein-a-potential-marker-for-distinguishing-histological-grade-and-prognosis-in-ovarian-serous-carcinoma
#13
Xiao Chen, Xuan Wang, Xue Wei, Jiandong Wang
BACKGROUND: Ovarian serous carcinoma (OSC) is the most common ovarian epithelial malignancy. Disregulation of Eph/ephrin signaling has been implicated in oncogenesis and tumor progression. EphA5 receptor is one of large families of Eph tyrosine kinase receptor and is documented in the development of nervous system. Till now, there is no published data about the role of EphA5 in ovarian epithelial neoplasmas. METHODS: This study aims to investigate the expression of EphA5 protein in ovarian serous carcinoma, and its relationship to clinical pathological characteristics...
November 25, 2016: Journal of Ovarian Research
https://www.readbyqxmd.com/read/27884514/less-radical-surgery-for-early-stage-cervical-cancer-can-conization-specimens-help-identify-patients-at-low-risk-for-parametrial-involvement
#14
Blair Smith, Georgia A McCann, Gary Phillips, Floor J Backes, David M O'Malley, David E Cohn, Jeffrey M Fowler, Larry J Copeland, Ritu Salani
OBJECTIVE: Radical hysterectomy for cervical cancer is associated with increased morbidity over an extrafascial hysterectomy. The goal of this study was to determine incidence of and risk factors for parametrial involvement (PI) based on conization specimen (CS) and to potentially identify candidates for less radical surgery. METHODS: Patients with FIGO IA2-IIA cervical cancer treated with radical hysterectomy and pelvic lymph node dissection (RH) from 2000 to 2010 were retrospectively identified...
November 21, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27882757/-contribution-of-sentinel-lymph-node-biopsy-to-treatment-of-locally-advanced-stages-of-cervical-cancers
#15
J Sláma, M Zikán, D Fischerová, R Kocián, A Germanová, F Frühauf, D Cibula
OBJECTIVE: Usage of sentinel lymph-node (SLN) concept in locally advanced cervical cancers might help to individualise management. According to SLN status could be patients refered to neoadjuvant chemotherapy (NAC) with subsequent surgery or to primary chemoradiation. The aim of our study was to evaluate sensitivity of SLN detection in locally advanced cervical cancers and to assess the impact of NAC on frequency of their metastatic involvement. DESIGN: Retrospective clinical study...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27881002/expression-of-orphan-gpr56-correlates-with-tumor-progression-in-human-epithelial-ovarian-cancer
#16
Z Liu, Z Huang, W Yang, Z Li, S Xing, H Li, B Hu, P Li
G protein-coupled receptor 56 (GPR56) has been demonstrated to be a significant prognostic predictor in several types of malignances, including melanoma, glioblastoma, breast cancer, colon cancer, and pancreatic cancer. GPR56 has a putative mucin-like extracellular domain, indicating functions for this receptor in the cell-cell interactions and triggering different downstream signaling pathways responsible for regulating cell survival, proliferation, adhesion, and migration. But the expression and clinical significance of GPR56 has not been elucidated in epithelial ovarian cancer (EOC)...
November 24, 2016: Neoplasma
https://www.readbyqxmd.com/read/27878258/microrna-362-is-downregulated-in-cervical-cancer-and-inhibits-cell-proliferation-migration-and-invasion-by-directly-targeting-six1
#17
Can Shi, Zhenyu Zhang
Cervical cancer is the second most common type of cancer in women accounting for 12% of all human cancers in the world. Mounting evidence demonstrates that microRNAs play important roles in the carcinogenesis and progression of cervical cancer. The aim of this study was to investigate the expression, roles and molecular mechanism of microRNA-362 (miR-362) in cervical cancer. According to the results, we found that expression level of miR-362 was significantly reduced in cervical cancer tissues and cell lines...
November 15, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27874289/epigenetic-changes-as-prognostic-predictors-in-endometrial-carcinomas
#18
Sanja A Farkas, Bengt G Sorbe, Torbjörn K Nilsson
Endometrial carcinoma is one of the most frequent gynecological malignancies of the female. The diagnostic and prognostic markers for the high-risk subgroups with unfavorable prognosis are under intense debate worldwide, and, therefore, the aim of this study was to identify new potential DNA methylation markers for the high-risk groups. We used the Illumina Infinium HumanMethylation450 BeadChip to analyze the DNA methylation pattern and investigated its association with clinicopathological features important for defining the high-risk (FIGO-grade 3) and low-risk (FIGO-grade 1) groups of patients with endometrial cancer (n = 31 and n = 39, respectively)...
November 22, 2016: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/27871269/institutionalizing-postpartum-intrauterine-device-iud-services-in-sri-lanka-tanzania-and-nepal-study-protocol-for-a-cluster-randomized-stepped-wedge-trial
#19
David Canning, Iqbal H Shah, Erin Pearson, Elina Pradhan, Mahesh Karra, Leigh Senderowicz, Till Bärnighausen, Donna Spiegelman, Ana Langer
BACKGROUND: During the year following the birth of a child, 40% of women are estimated to have an unmet need for contraception. The copper IUD provides safe, effective, convenient, and long-term contraceptive protection that does not interfere with breastfeeding during the postpartum period. Postpartum IUD (PPIUD) insertion should be performed by a trained provider in the early postpartum period to reduce expulsion rates and complications, but these services are not widely available. The International Federation of Obstetricians and Gynecologists (FIGO) will implement an intervention that aims to institutionalize PPIUD training as a regular part of the OB/GYN training program and to integrate it as part of the standard practice at the time of delivery in intervention hospitals...
November 21, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27869985/agreement-and-accuracy-using-the-figo-acog-and-nice-cardiotocography-interpretation-guidelines
#20
Susana Santo, Diogo Ayres-De-Campos, Cristina Costa-Santos, William Schnettler, Austin Ugwumadu, Luís Mendes Da Graça
INTRODUCTION: One of the limitations reported with cardiotocography (CTG) is the modest interobserver agreement observed in tracing interpretation. This study compared agreement, reliability and accuracy of CTG interpretation using the FIGO, ACOG and NICE guidelines. MATERIAL AND METHODS: A total of 151 tracings was evaluated by 27 clinicians from three centers where FIGO, ACOG and NICE guidelines were routinely used. Interobserver agreement was evaluated using the proportions of agreement (PA) and reliability with the kappa (k) statistic...
November 21, 2016: Acta Obstetricia et Gynecologica Scandinavica
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