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https://www.readbyqxmd.com/read/29239819/lncrna-hoxd-as1-promotes-epithelial-ovarian-cancer-cells-proliferation-and-invasion-by-targeting-mir-133a-3p-and-activating-wnt-%C3%AE-catenin-signaling-pathway
#1
Ying Zhang, Yanbing Dun, Shumin Zhou, Xiang-Hua Huang
BACKGROUND: Long non-coding RNA (lncRNA) HOXD cluster antisense RNA 1 (HOXD-AS1) functions as a crucial regulator in the progression and development of tumors. The aim of this study is to unravel the underlying mechanisms of HOXD-AS1 on epithelial ovarian cancer (EOC). METHODS: 43 paired EOC tissues and adjacent non-tumor tissues were collected postoperatively from patients. QRT-PCR was used to explore HOXD-AS1 expression in both EOC tissues and cell lines. Cell proliferation and invasion were monitored by MTT assay and transwell invasion assay...
November 24, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29237910/clinical-significance-of-twist-e-cadherin-and-n-cadherin-protein-expression-in-endometrioid-adenocarcinoma
#2
Xinping Xie, Xiu Zheng, Jinhua Wang, Lihong Chen
OBJECTIVE: The aim of the study was to investigate the expression of Twist, E-cadherin, and N-cadherin both in normal endometrium and in endometrioid adenocarcinoma tissues (NET and EAT), and further discuss the relationship between the proteins expression and the clinical parameters. METHODS: Seventy-six EAT and 50 NET were collected from endometrioid adenocarcinoma patients and patients who received hysterectomy. We used immunohistochemistry (two steps methods) to detect the expression of Twist, E-cadherin, and N-cadherin proteins in EAT and NET...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29237907/long-noncoding-rna-activated-by-transforming-growth-factor-%C3%AE-promotes-cancer-development-and-is-a-prognostic-marker-in-cervical-cancer
#3
Weichun Cao, Tianfang Peng, Yi Zhou
BACKGROUND: Long noncoding RNAs (lncRNAs) have been highlighted as crucial elements in cancer biology. LncRNA activated by transforming growth factor-β (ATB) was identified to promote the development of multiple cancers and may serve as a potential therapeutic target in human cancers. However, to the best of our knowledge, the functional role of ATB in cervical cancer has not been verified yet. MATERIALS AND METHODS: The expression of lncRNA ATB was evaluated by quantitative reverse transcriptase-polymerase chain reaction assay in cervical cancer cell lines and clinical specimens...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29233120/prediction-of-5-year-overall-survival-in-cervical-cancer-patients-treated-with-radical-hysterectomy-using-computational-intelligence-methods
#4
Bogdan Obrzut, Maciej Kusy, Andrzej Semczuk, Marzanna Obrzut, Jacek Kluska
BACKGROUND: Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artificial intelligence models for 5-year overall survival prediction in patients with cervical cancer treated by radical hysterectomy. METHODS: The data set was collected from 102 patients with cervical cancer FIGO stage IA2-IIB, that underwent primary surgical treatment...
December 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29232805/value-of-imaging-study-in-predicting-pelvic-lymph-node-metastases-of-uterine-cervical-cancer
#5
Wonguen Jung, Kyung Ran Park, Kyung-Ja Lee, Kyubo Kim, Jihae Lee, Songmi Jeong, Yi-Jun Kim, Jiyoung Kim, Hai-Jeon Yoon, Byung-Chul Kang, Hae Soo Koo, Sun Hee Sung, Min-Sun Cho, Sanghui Park
Purpose: To evaluate the diagnostic accuracy of computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography/computed tomography (PET/CT) in predicting pelvic lymph node (LN) metastases in patients with cervical cancer. Materials and Methods: From January 2009 to March 2015, 114 patients with FIGO stage IA1-IIB uterine cervical cancer who underwent hysterectomy with pelvic lymphadenectomy and took CT, MRI, and PET/CT before surgery were enrolled in this study...
December 15, 2017: Radiation Oncology Journal
https://www.readbyqxmd.com/read/29232468/the-new-classifications-of-ovarian-fallopian-tube-and-primary-peritoneal-cancer-and-their-clinical-implications
#6
L R Duska, E C Kohn
The roles of histologic characterization and staging are to provide reproducible metrics for cancer classification with which to direct the most appropriate clinical care and to yield the most stable reliable system to allow both prospective and retrospective data analysis. Both the histologic and staging classifications of malignant ovarian/tubal/peritoneal cancers have recently changed. The World Health Organization sponsored a review and reclassification of the pathology of cancers of the ovaries, fallopian tubes, and peritoneum, and published these updates in 2014...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29231068/clinicopathological-and-prognostic-significance-of-platelet-count-in-patients-with-ovarian-cancer
#7
Q Zhou, F Huang, Z He, M-Z Zuo
AIM: Increasing evidence indicates that platelet count is a useful biomarker of long-term outcomes in patients with ovarian cancer. However, the prognostic value of platelet count in patients with ovarian cancer remains controversial. We therefore conducted a meta-analysis aimed to investigate the prognostic role of the platelet count in patients with ovarian cancer. METHOD: A comprehensive search was performed from the databases of PubMed, Embase and the Cochrane Library until June 20, 2017...
December 12, 2017: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29228737/reduced-m6a-mrna-methylation-is-correlated-with-the-progression-of-human-cervical-cancer
#8
Xiuli Wang, Zenghui Li, Beihua Kong, Chen Song, Jianglin Cong, Jianqing Hou, Shaoguang Wang
The m6A mRNA methylation involves in mRNA splicing, degradation and translation. Recent studies have revealed that reduced m6A mRNA methylation might promote cancer development. However, the role of m6A mRNA methylation in cervical cancer development remains unknown. Therefore, we investigated the role of m6A methylation in cervical cancer in the current study. We first evaluated the m6A mRNA methylation level in 286 pairs of cervical cancer samples and their adjacent normal tissues by dot blot assay. Then the role of m6A on patient survival rates and cervical cancer progression were assessed...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29223598/prognosis-and-treatment-of-positive-peritoneal-cytology-in-early-endometrial-cancer-matched-cohort-analyses-from-the-national-cancer-database
#9
Brandon-Luke L Seagle, Amy L Alexander, Taliya Lantsman, Shohreh Shahabi
BACKGROUND: While positive peritoneal cytology is no longer included among the endometrial cancer staging criteria, FIGO recommends continued collection of pelvic washings for cytology in order to produce additional data that may be used to determine the significance of positive cytology for prognosis and treatment of endometrial cancer. OBJECTIVES: To validate that positive cytology is a predictor of decreased survival in early endometrial cancer and to test if adjuvant chemotherapy for positive cytology is associated with increased survival...
December 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29223564/indocyanine-green-assisted-parametrial-dissection-during-type-c1-radical-hysterectomy-after-sentinel-lymph-node-biopsy-in-early-stage-cervical-cancer
#10
Nicolò Bizzarri, Valentina Ghirardi, Ali Kucukmetin
OBJECTIVES: The standard treatment for FIGO stage 1B1 cervical cancer is radical hysterectomy (RH) [1]. Indocyanine-green (ICG) is a drug injected within the cervical stroma to detect the sentinel lymph node (SLN) in cervical cancer [2,3]. ICG travels through the lymphatic channels in the lateral parametrium, which results enhanced with green, before reaching the SLNs. This could help identifying the surgical landmarks. The aim of this video is to propose a new approach to perform parametrial dissection as part of RH under the guidance of ICG...
December 6, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29222685/prediction-of-outcome-using-pretreatment-18f-fdg-pet-ct-and-mri-radiomics-in-locally-advanced-cervical-cancer-treated-with-chemoradiotherapy
#11
François Lucia, Dimitris Visvikis, Marie-Charlotte Desseroit, Omar Miranda, Jean-Pierre Malhaire, Philippe Robin, Olivier Pradier, Mathieu Hatt, Ulrike Schick
PURPOSE: The aim of this study is to determine if radiomics features from 18fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and magnetic resonance imaging (MRI) images could contribute to prognoses in cervical cancer. METHODS: One hundred and two patients (69 for training and 33 for testing) with locally advanced cervical cancer (LACC) receiving chemoradiotherapy (CRT) from 08/2010 to 12/2016 were enrolled in this study. 18F-FDG PET/CT and MRI examination [T1, T2, T1C, diffusion-weighted imaging (DWI)] were performed for each patient before CRT...
December 9, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29221135/silencing-of-bag3-inhibits-the-epithelial-mesenchymal-transition-in-human-cervical-cancer
#12
Fei Song, Geng Wang, Zhifang Ma, Yuebing Ma, Yingying Wang
Bcl2-associated athanogene 3 (BAG3) has been reported to be involved in aggressive progression of many tumors. In the present study, we examined the expression of BAG3 in human cervical cancer (CC) tissues and investigated the role of BAG3 in SiHa and HeLa cell growth, migration, and invasion. Here, we found that most of CC tissues highly expressed the protein and mRNA of BAG3, while their expression was obviously lower in paired normal tissues (all p<0.001). BAG3 expression was associated with FIGO stage and metastasis (all p<0...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218242/long-noncoding-rna-lncbrm-facilitates-the-proliferation-migration-and-invasion-of-ovarian-cancer-cells-via-upregulation-of-sox4
#13
Jie Xi, Jing Feng, Saitian Zeng
Ovarian cancer (OC) is one of the most fatal gynecological cancer in women worldwide. Long noncoding RNA (lncRNA) lncBRM was found to be associated with the progression and prognosis of hepatocellular carcinoma (HCC). However, the expression level, clinical significance and functions in OC tumorigenesis and progression remain unclear. Our present research demonstrated that lncBRM expression was significantly increased in OC tissues. Upregulation of lncBRM expression was correlated with histological grade, FIGO stages, lymph node metastasis and poor prognosis of patients with OC...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29215160/new-figo-and-swedish-intrapartum-cardiotocography-classification-systems-incorporated-in-the-fetal-ecg-st-analysis-stan-interpretation-algorithm-agreements-and-discrepancies-in-cardiotocography-classification-and-evaluation-of-significant-st-events
#14
Per Olofsson, Håkan Norén, Ann Carlsson
The updated intrapartum cardiotocography (CTG) classification system by FIGO in 2015 (FIGO2015) and the FIGO2015-approached classification by the Swedish Society of Obstetricians and Gynecologist in 2017 (SSOG2017) are not harmonized with the fetal ECG ST analysis (STAN) algorithm from 2007 (STAN2007). The study aimed to reveal homogeneity and agreement between the systems in classifying CTG and ST events, and relate to maternal and perinatal outcomes MATERIAL AND METHODS: Among CTG traces with ST events, 100 traces originally classified as normal, 100 as suspicious and 100 as pathological were randomly selected from a STAN database and classified by two experts in consensus...
December 7, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29211304/risk-of-recurrence-prognosis-and-follow-up-for-danish-women-with-cervical-cancer-in-2005-2013-a-national-cohort-study
#15
Gry Assam Taarnhøj, Ib Jarle Christensen, Henrik Lajer, Katrine Fuglsang, Mette Moustgaard Jeppesen, Henriette Strøm Kahr, Claus Høgdall
BACKGROUND: In developed countries, women attend follow-up after treatment for cervical cancer to detect recurrence. The aim of this study was to describe the Danish population of women with early-stage cervical cancer at risk for recurrence and death due to recurrence. METHODS: Data were extracted from 3 nationwide databases to find women diagnosed with stage 1A1 to 1B1 cervical cancer in 2005-2013. Recurrences were determined from data on oncological or surgical treatment more than 3 months after the initial diagnosis and were cross-checked with patient journals...
December 6, 2017: Cancer
https://www.readbyqxmd.com/read/29207663/microrna-218-inhibits-proliferation-and-invasion-in-ovarian-cancer-by-targeting-runx2
#16
Na Li, Lufei Wang, Guangyun Tan, Zhiheng Guo, Lei Liu, Ming Yang, Jin He
MicroRNA-218 (miR-218) has been implicated in the development and progression of multiple cancers. We investigated the role of miR-218 in ovarian cancer progression. We found that miR-218 expression levels were lower in ovarian cancer tissues and cell lines than in adjacent normal tissues or a normal ovarian cell line.miR-218 levels associated with International Federation of Gynecology and Obstetrics (FIGO) stage and lymph node metastasis. Exogenous expression of miR-218 inhibited cell proliferation, colony formation, migration, and invasion in vitro and suppressed tumor growth in a tumor-bearing nude mouse model...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29201921/selective-screening-strategies-for-gestational-diabetes-a-prospective-cohort-observational-study
#17
Sumaiya Adam, Paul Rheeder
Aim: We aimed to develop a prediction model for the diagnosis of gestational diabetes and to evaluate the performance of published prediction tools on our population. Methods: We conducted a cohort study on nondiabetic women < 26 weeks gestation at a level 1 clinic in Johannesburg, South Africa. At recruitment, participants completed a questionnaire and random basal glucose and HbA1c were evaluated. A 75 g 2-hour OGTT was scheduled between 24-28 weeks gestation, as per FIGO guidelines...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29198495/prognostic-value-of-peritoneal-cancer-index-in-primary-advanced-ovarian-cancer
#18
Antoni Llueca, Javier Escrig
BACKGROUND: Effective tumor debulking is a major factor associated with a favorable prognosis in patients with advanced ovarian cancer (AOC). However, FIGO staging fails to take full account of the extent of the disease in the peritoneum, making it difficult to plan appropriate surgical treatment. In contrast, the peritoneal cancer index (PCI) can provide more detailed information about peritoneal spread. METHOD: We evaluated the prognostic value of PCI and its association with clinicopathological features in patients with AOC...
November 23, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29194596/truncated-isoform-vav3-1-is-highly-expressed-in-ovarian-cancer-stem-cells-and-clinically-relevant-in-predicting-prognosis-and-platinum-response
#19
Daniel Reimer, Maximilian Boesch, Dominik Wolf, Christian Marth, Sieghart Sopper, Jiri Hatina, Peter Altevogt, Walther Parson, Hubert Hackl, Alain G Zeimet
Vav3 is a key modulator of GTP-hydrolases of the Rho/Rac family, which are crucially involved in cell proliferation. Vav3 is alternatively spliced in full-length Vav3-alpha and N-terminal truncated Vav3.1 lacking its self-regulatory domains. The aim of this study was to estimate the clinical impact of Vav3 and all other Vav family members in ovarian cancer. Purification of a stem-cell like side-population (SP) from ovarian cancer cell lines was performed by flow cytometry/FACS. Differences in gene expression between SP and NSP were assessed by Gene Array analysis and confirmed by RT-PCR and immunoblot...
December 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29192416/mig-7-expression-and-vasculogenic-mimicry-in-malignant-ovarian-tumors
#20
Artur Czekierdowski, Sylwia Czekierdowska, Norbert Stachowicz, Tomasz Łoziński, Grzegorz Gurynowicz
OBJECTIVES: To investigate the possible association of vasculogenic mimicry (VM), VE-cadherin and MIG-7 expression with clinicopathological features of women with malignant ovarian masses. MATERIAL AND METHODS: VM was studied with the PAS reaction and VE-cadherin was assessed with immunohistochemistry in 108 women with malignant ovarian tumors. Additionally, quantitative expression of MIG-7 mRNA was performed in 52 ovarian cancers with qRT-PCR. RESULTS: VM was found in 48/108 cases (44%), more often in higher FIGO stage tumors (83% cases; 40 vs...
2017: Ginekologia Polska
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