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https://www.readbyqxmd.com/read/28101917/imaging-in-gynecological-disease-clinical-and-ultrasound-features-of-invasive-and-non-invasive-malignant-serous-ovarian-tumors
#1
F Moro, C Baima Poma, G F Zannoni, A Vidal Urbinati, T Pasciuto, M Ludovisi, M C Moruzzi, S Carinelli, D Franchi, G Scambia, A C Testa
OBJECTIVES: To describe clinical and ultrasound features of different subclasses of malignant serous ovarian tumors according to the WHO 2014 classification. METHODS: Patients with a histological diagnosis of borderline (BOT), non-invasive and invasive low grade serous carcinomas (LGSC) and high grade serous carcinoma (HGSC), who had undergone preoperative ultrasound examination, were retrospectively identified from two ultrasound centers. The masses were described using the terms of the International Ovarian Tumor Analysis group...
January 19, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28099743/professionally-responsible-advocacy-for-professional-liability-law
#2
(no author information available yet)
No abstract text is available yet for this article.
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28099738/professionalism-in-obstetric-and-gynecologic-practice
#3
(no author information available yet)
No abstract text is available yet for this article.
February 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28092915/malignant-mixed-m%C3%A3-llerian-tumour-of-the-uterus-analysis-of-44-cases
#4
Silvana Grasso, Vera Loizzi, Valentina Minicucci, Leonardo Resta, Anna Lina Camporeale, Ettore Cicinelli, Gennaro Cormio
OBJECTIVES: The aim of our study was to evaluate the clinicopathological features and prognostic factors of uterine carcinosarcoma. PATIENTS AND METHODS: In this retrospective study, the clinical characteristics of 44 patients with uterine MMMT were evaluated. Survival curves were estimated by the Kaplan-Meier method and compared by the log-rank test. RESULTS: Forty-four patients with uterine carcinosarcoma were referred to our unit between 1995 and 2015...
January 17, 2017: Oncology
https://www.readbyqxmd.com/read/28088836/upregulation-of-long-noncoding-rna-tug1-promotes-cervical-cancer-cell-proliferation-and-migration
#5
Yingying Hu, Xiangwei Sun, Chenchen Mao, Gangqiang Guo, Sisi Ye, Jianfeng Xu, Ruanmin Zou, Jun Chen, Ledan Wang, Ping Duan, Xiangyang Xue
Long noncoding RNAs (lncRNAs), a novel class of transcripts that have critical roles in carcinogenesis and progression, have emerged as important gene expression modulators. Recent evidence indicates that lncRNA taurine-upregulated gene 1 (TUG1) functions as an oncogene in numerous types of human cancers. However, its function in the development of cervical cancer remains unknown. The aim of this research was to investigate the clinical significance and biological functions of TUG1 in cervical cancer. TUG1 was found to be significantly upregulated in cervical cancer tissues and four cervical cancer cell lines by quantitative real-time polymerase chain reaction (qRT-PCR)...
January 15, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28074045/high-expression-of-stromal-cell-derived-factor-1-sdf-1-and-nf-%C3%AE%C2%BAb-predicts-poor-prognosis-in-cervical-cancer
#6
Zhiwang Song, Xia Zhang, Xiaojuan Ye, Chan Feng, Guang Yang, Yonglin Lu, Yun Lin, Chunyan Dong
BACKGROUND SDF-1 and NF-κB are associated with the prognosis of a wide range of cancers, but their value in cervical cancer remains controversial. The aim of this study was to investigate the expression of SDF-1and NF-κB in cervical cancer and their significance in clinical prognosis. MATERIAL AND METHODS The expression of SDF-1and NF-κB in 105 formalin-fixed, paraffin-embedded cervical cancer tissues and the adjacent tissues was examined by immunohistochemistry (IHC). The results were semi-quantitatively scored and analyzed by chi-square test...
January 11, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28073597/en-bloc-resection-of-the-pelvis-enbrp-in-patients-with-stage-iiic-iv-ovarian-cancer-a-10-steps-standardised-technique-surgical-and-survival-outcomes-of-primary-vs-interval-surgery
#7
Roberto Tozzi, Kieran Hardern, Kumar Gubbala, Riccardo Garruto Campanile, Hooman Soleymani Majd
OBJECTIVE: In this study we describe the technique of the En-bloc resection of the pelvis (EnBRP) in 10 standardised and reproducible steps, whereby all pelvic organs, except the bladder, are removed together with the peritoneum. In addition, we compare the surgical and survival outcomes of patients who underwent upfront vs. interval surgery. METHODS: Retrospective analysis of patients with FIGO Stage IIIC-IV ovarian cancer treated with Visceral Peritoneal Debulking (VPD) who had EnBRP...
January 7, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28068595/the-impact-of-lymphadenectomy-on-survival-endpoints-in-women-with-early-stage-uterine-endometrioid-carcinoma-a-matched-analysis
#8
Ahmed I Ghanem, Nadia T Khan, Meredith Mahan, Ahmed Ibrahim, Thomas Buekers, Mohamed A Elshaikh
OBJECTIVES: The role of pelvic lymphadenectomy (LA) in women with stage I endometrial carcinoma (EC) is controversial. The objective of this study is to investigate the prognostic impact of LA on survival endpoints in matched cohorts of women with stage I EC solely of endometrioid histology. Survival endpoints included recurrence-free (RFS), disease-specific (DSS) and overall survival (OS). METHODS AND MATERIALS: Patients with FIGO stage I EC who underwent hysterectomy with LA as part of their surgical staging between 1/1990 and 6/2015 were matched to a similar group that underwent hysterectomy without lymphadenectomy (NLA), based on stage, grade and adjuvant management...
December 28, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28065812/minimally-invasive-approach-in-type-ii-endometrial-cancer-it-is-wise-and-safe
#9
Giorgia Monterossi, Fabio Ghezzi, Enrico Vizza, Gian Franco Zannoni, Stefano Uccella, Giacomo Corrado, Stefano Restaino, Lorena Quagliozzi, Jvan Casarin, Giorgia Dinoi, Giovanni Scambia, Francesco Fanfani
STUDY OBJECTIVE: The aims of this study were to compare peri-operative and survival outcomes of Type II endometrial cancers patients staged by minimally invasive approaches versus laparotomy. DESIGN: A retrospective cohort study. DESIGN: Classification: Canadian Task Force classification II-2 SETTING: Catholic University of the Sacred Heart of Rome, University of Insubria, Varese and "Regina Elena" National Cancer Institute of Rome. PATIENTS: We enrolled 283 Type II endometrial cancer patients with clinical FIGO stage I-II and pathological stage III with apparent early-stage disease at the pre-operative instrumental examination...
January 5, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28060141/pd-l1-expression-in-premalignant-and-malignant-trophoblasts-from-gestational-trophoblastic-diseases-is-ubiquitous-and-independent-of-clinical-outcomes
#10
Pierre-Adrien Bolze, Sophie Patrier, Jérôme Massardier, Touria Hajri, Fatima Abbas, Anne Marie Schott, Fabienne Allias, Mojgan Devouassoux-Shisheboran, Gilles Freyer, François Golfier, Benoît You
OBJECTIVE: Recently reported expression of programmed cell death 1 ligand 1 (PD-L1) in gestational trophoblastic diseases (GTDs) suggests that the immune tolerance of pregnancy might be hijacked during neoplastic process. We assessed PD-L1 protein expression in premalignant and malignant GTD lesions and analyzed associations with disease severity and chemotherapy outcomes. METHODS: We included 83 GTD whole-tissue sections from 76 patients in different treatment settings...
January 4, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28057128/-expression-and-function-of-long-intergenic-non-protein-coding-rna-regulator-of-reprogramming-in-high-grade-ovarian-serous-cancer
#11
H H Jiang, Y H Lou, X Y Wang, Y Han, Z M Cui
Objective: To investigate the expression of long intergenic non-protein coding RNA-regulator of reprogramming (Linc-ROR) in high-grade ovarian serous cancer, and explore the relationship between Linc-ROR expression and biological function of high-grade ovarian serous cancer. Methods: A total of 34 high-grade ovarian serous cancer tissue samples and 19 normal fallopian tube tissue samples were collected between June 2014 and February 2016. Real-time reverse transcription (RT)-PCR was used to detect the Linc-ROR mRNA expression in different samples...
December 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28052947/primitive-neuroectodermal-tumour-of-the-cervix-a-rare-diagnosis
#12
Irfan Ahmad, Kundan Singh Chufal, Amit Bhargava, Irfan Bashir
A 48-year-old woman presented with symptoms of lower abdominal pain and vaginal discharge for 6 months. Clinical examination and pelvic ultrasound scan suggested a diagnosis of infected Gartner's cyst, for which she underwent vaginal cystectomy. However, histopathology and immunohistochemistry revealed a diagnosis of primitive neuroectodermal tumour of the cervix. Further investigations revealed the stage to be FIGO IIIB, which was inoperable. She received neoadjuvant chemotherapy (vincristine, adriamycin, cyclophosphamide alternating with ifosfamide, cisplatin and etoposide, every 21 days), but the tumour did not respond to treatment and she was started on radiotherapy with definitive intent (55...
January 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28052682/prognostic-significance-of-mapk-topo-ii%C3%AE-and-e-cadherin-immunoexpression-in-ovarian-serous-carcinomas
#13
D Sundov, B Petric Mise, I Mrklic, B Bacic, E Vrdoljak, S Tomis
Ovarian cancer accounts for only 3% of all cancers in women but is the most lethal gynaecologic malignancy. Low-grade and high-grade ovarian serous carcinomas (OSCs) represent two different diseases with different prognosis, approaches to detection and treatment. We assessed correlation between, MAPK, topoIIα, E-cadherin immunoexpression and clinicopathological features with overall survival (OS) in OSCs. The study included 81 patients undergoing surgery between January 1995 and December 2005.Formalin fixed paraffin embedded tumour sections were reviewed and examined immunohistochemically using antibodies against MAPK, topoIIα and E-cadherin...
January 5, 2017: Neoplasma
https://www.readbyqxmd.com/read/28042955/a-novel-nomogram-based-on-lodds-to-predict-the-prognosis-of-epithelial-ovarian-cancer
#14
Xue-Lian Xu, Hao Cheng, Meng-Si Tang, Hai-Liang Zhang, Rui-Yan Wu, Yan Yu, Xuan Li, Xiu-Min Wang, Jia Mai, Chen-Lu Yang, Lin Jiao, Zhi-Ling Li, Zhen-Mei Zhong, Rong Deng, Jun-Dong Li, Xiao-Feng Zhu
BACKGROUND: To develop and validate a nomogram based on log of odds between the number of positive lymph node and the number of negative lymph node (LODDS) in predicting the overall survival (OS) and cancer specific survival (CSS) for epithelial ovarian cancer (EOC) patients. MATERIALS AND METHODS: A total of 10,692 post-operative EOC patients diagnosed between 2004 and 2013 were obtained from the Surveillance, Epidemiology, and End Results (SEER) database and randomly divided into training (n = 7,021) and validation (n = 3,671) cohorts...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28039537/hyaluronic-acid-binding-protein-1-overexpression-is-an-indicator-for-disease-free-survival-in-cervical-cancer
#15
Ming Zhang, Na Li, Yannan Liang, Jinhui Liu, Yafeng Zhou, Chunying Liu
BACKGOUND: Hyaluronic acid binding protein 1 (HABP1) is reported to overexpress in various cancer tissues and may therefore contribute to oncogenesis. However, the status of HABP1 expression in cervical cancer (CC) remains unknown. The aim of this study was to investigate the role of HABP1 and its relationship with clinical characteristics in patients with CC. METHODS: Immunohistochemistry was used to explore the expression of HABP1 in 30 cervical intra-epithelial neoplasia (CIN) and 118 CC specimens compared to 10 normal cervical specimens...
December 30, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28039471/aneuploidy-related-transcriptional-changes-in-endometrial-cancer-link-low-expression-of-chromosome-15q-genes-to-poor-survival
#16
Karen Klepsland Mauland, Elisabeth Wik, Erling A Hoivik, Kanthida Kusonmano, Mari Kyllesø Halle, Anna Berg, Hans Kristian Haugland, Anne Margrete Øyan, Karl-Henning Kalland, Ingunn Marie Stefansson, Lars A Akslen, Camilla Krakstad, Jone Trovik, Henrica Maria Johanna Werner, Helga Birgitte Salvesen
Aneuploidy is a widely studied prognostic marker in endometrial cancer (EC), however, not implemented in clinical decision-making. It lacks validation in large prospective patient cohorts adjusted for currently standard applied prognostic markers, including estrogen/progesterone receptor status (ER/PR). Also, little is known about aneuploidy-related transcriptional alterations, relevant for understanding its role in EC biology, and as therapeutic target.We included 825 EC patients with available ploidy status and comprehensive clinicopathologic characterization to analyze ploidy as a prognostic marker...
December 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/28038476/single-site-robotic-radical-hysterectomy-and-sentinel-lymphnode-biopsy-in-cervical-cancer-a-case-report
#17
Alexandre Silva E Silva, Rodrigo Pinto Fernandes, Marcia Pereira de Araujo, João Paulo Mancusi de Carvalho, Filomena Marino Carvalho, Giovani Mastrantônio Favero, Jesus Paula Carvalho
Robotic surgeries for cervical cancer have several advantages compared with laparotomic or laparoscopic surgeries. Robotic single-site surgery has many advantages compared with the multiport approach, but its safety and feasibility are not established in radical oncologic surgeries. We report a case of a Federation of Gynecology and Obstetrics (FIGO) stage IB1 cervical carcinoma whose radical hysterectomy, sentinel lymph node mapping, and lymph node dissection were entirely performed by robotic single-site approach...
December 30, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28029448/long-term-results-from-a-prospective-database-on-high-dose-rate-hdr-interstitial-brachytherapy-for-primary-cervical-carcinoma
#18
Julia Fallon, Sang-Jung Park, Lisa Yang, Darlene Veruttipong, Mingle Zhang, Thanh Van, Pin-Chieh Wang, Alexandra M Fekete, Mauricio Cambeiro, Mitchell Kamrava, Michael L Steinberg, D Jeffrey Demanes
OBJECTIVE: Present long-term outcomes in primary cervical cancer treated with external beam and high dose rate interstitial brachytherapy. METHODS: High dose rate (HDR) interstitial (IS) brachytherapy (BT) and external beam (EBRT) were administered from 1992 to 2009 to 315 patients who were unsuitable for intracavitary (IC) BT alone. Histology was 89% squamous cell, 8% adenocarcinoma, and 3% adenosquamous. FIGO stage was I-14%, II-47%, III-34%, and IVA-5%. Median tumor size was 6cm...
October 29, 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/28024138/set-and-mynd-domain-containing-protein-3-smyd3-polymorphism-as-a-risk-factor-for-susceptibility-and-poor-prognosis-in-ovarian-cancer
#19
Ting-Ting Liu, Hui Xu, Wei-Ping Gao, Shu-Xiang Zhang, Xu-Hong Zhou, Juan Tang, Qiong-Na Liu
BACKGROUND We investigated the relationship of the polymorphisms of SET and MYND domain-containing protein 3 (SMYD3) with risk and prognosis of ovarian cancer. MATERIAL AND METHODS The polymerase chain reaction (PCR) amplification method was applied to detect the polymorphisms of variable number of tandem repeats (VNTR) in the SMYD3 gene promoter region for 156 patients with ovarian cancer (case group) and 174 healthy people (control group). Quantitative reverse transcription polymerase chain reaction and Western blot were applied to detect SMYD3 mRNA and protein expressions...
December 26, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28013346/the-expression-of-foxp3-and-tlr4-in-cervical-cancer-association-with-immune-escape-and-clinical-pathology
#20
Huijie Zhang, Shulan Zhang
PURPOSE: To explore the expression of forkhead/winged helix transcription factor p3(Foxp3) and toll-like receptor 4(TLR4) in cervical cancer and evaluate their clinical significance. METHODS: Foxp3 and TLR4 protein expression was detected in 105 cervical tissue specimens including cervical cancer, cervical intraepithelial neoplasia (CIN), and healthy control samples using immunohistochemistry. Their relationship with clinicopathologic parameters was also determined...
December 24, 2016: Archives of Gynecology and Obstetrics
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