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https://www.readbyqxmd.com/read/28718876/is-there-a-revision-needed-of-the-current-figo-staging-system
#1
Joseph Menczer
The FIGO staging system has undergone many modifications since it first appeared in about the middle of the previous century. Due to the use of modern diagnostic tools, namely computed tomography, magnetic resonance imaging, positron emission tomography, sentinel lymph node biopsy and of neoadjuvant chemotherapy, certain gynecological cancer cases cannot be allocated to a specific stage if one wishes to adhere strictly to FIGO requirements. In these circumstances such cases remain actually unstaged. This should prompt appropriate modifications of the current FIGO staging system so that it fulfills its aims...
July 18, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28716307/should-epithelial-ovarian-carcinoma-metastatic-to-the-inguinal-lymph-nodes-be-assigned-stage-ivb
#2
Dimitrios Nasioudis, Eloise Chapman-Davis, Melissa K Frey, Thomas A Caputo, Steven S Witkin, Kevin Holcomb
OBJECTIVE: According to the revised FIGO staging system women with ovarian carcinoma and inguinal lymph node (LN) metastases, formerly stage III, are now considered stage IVB. In this study we compare their survival to that of women with stage III and stage IV disease. METHODS: Women diagnosed with epithelial ovarian carcinoma were drawn from the Surveillance, Epidemiology, and End Results database (2004-2013). Four groups were formed: group 1 (stage IV due to positive inguinal nodes), group 2 (stage III with positive para-aortic/pelvic nodes), group 3 (stage IV with positive distant nodes) and group 4 (stage IV with distant metastases)...
July 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28716306/tertiary-cytoreductive-surgery-in-recurrent-epithelial-ovarian-cancer-a-multicentre-mito-retrospective-study
#3
F Falcone, G Scambia, P Benedetti Panici, M Signorelli, G Cormio, G Giorda, S Bogliolo, M Marinaccio, F Ghezzi, E Rabaiotti, E Breda, G Casella, F Fanfani, V Di Donato, U Leone Roberti Maggiore, S Greggi
OBJECTIVES: To evaluate the impact of tertiary cytoreductive surgery (TCS) on survival in recurrent epithelial ovarian cancer (EOC), and to determine predictors of complete cytoreduction. METHODS: A multi-institutional retrospective study was conducted within the MITO Group on a 5-year observation period. RESULTS: A total of 103 EOC patients with a ≥6month treatment-free interval (TFI) undergoing TCS were included. Complete cytoreduction was achieved in 71 patients (68...
July 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28716107/biomarkers-of-resistance-to-radiation-therapy-a-prospective-study-in-cervical-carcinoma
#4
P Moreno-Acosta, A Vallard, S Carrillo, O Gamboa, A Romero-Rojas, M Molano, J Acosta, D Mayorga, C Rancoule, M A Garcia, M Cotes Mestre, N Magné
BACKGROUND: Clinical parameters and proteins have recently been suggested as possible causes of radiotherapy (RT) resistance in cervical carcinoma (CC). The objective of the present study was to validate prognostic biomarkers of radiation resistance. METHODS: The present prospective study included patients undergoing RT with curative intent for histologically proven locally advanced squamous cell CC. Tissues and blood samples were systematically collected before RT initiation...
July 17, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28715088/clinical-limitations-of-the-international-federation-of-gynecology-and-obstetrics-figo-staging-of-uterine-fibroids
#5
Shannon K Laughlin-Tommaso, Gina K Hesley, Matthew R Hopkins, Kathleen R Brandt, Yunxiao Zhu, Elizabeth A Stewart
OBJECTIVE: To determine the reproducibility of classifying uterine fibroid using the 2011 International Federation of Gynecology and Obstetrics (FIGO) staging system. METHODS: The present retrospective cohort study included patients presenting for the treatment of symptomatic uterine fibroids at the Gynecology Fibroid Clinic at Mayo Clinic, Rochester, USA, between April 1, 2013 and April 1, 2014. Magnetic resonance imaging of fibroid uteri was performed and the images were independently reviewed by two academic gynecologists and two radiologists specializing in fibroid care...
July 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28710714/disseminated-tumor-cells-are-not-associated-with-established-risk-factors-l1cam-immunoreactivity-and-outcome-in-endometrial-carcinoma
#6
Stefan Kommoss, Andreas D Hartkopf, Bernhard Krämer, Anne-Kathrin Bunz, Friederike Grevenkamp, Felix Kommoss, Jana Pasternak, Sabine M Arbabi, Markus Wallwiener, Annette Staebler, Sigurd F Lax, Sara Y Brucker, Florin-Andrei Taran
PURPOSE: The presence of disseminated tumor cells (DTC) in the bone marrow of endometrial carcinoma patients has been demonstrated previously. In contrast to breast cancer, no prognostic significance or association with clinicopathological features was revealed for endometrial carcinoma so far. The aim of this study was to investigate DTC in a large patient cohort with in-depth pathology review data available and to study DTC occurrence in the context of L1CAM and long-term disease specific follow-up...
July 14, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28709703/extent-of-lymphovascular-space-invasion-may-predict-lymph-node-metastasis-in-uterine-serous-carcinoma
#7
Yushen Qian, Erqi L Pollom, Chika Nwachukwu, Kira Seiger, Rie von Eyben, Ann K Folkins, Elizabeth A Kidd
OBJECTIVES: Emerging evidence suggests that extent of lymphovascular space invasion (LVSI) predicts for risk of lymph node metastasis in endometrioid uterine cancers. However, this correlation remains unknown in the setting of uterine serous carcinoma (USC). We sought to examine the association between extent of LVSI and other histopathologic characteristics with risk of nodal metastasis for women with USC. MATERIALS/METHODS: Pathological data from all cases of uterine serous carcinoma between July 1998 to July 2015 at our institution were reviewed...
July 11, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28708791/self-reported-long-term-autonomic-function-after-laparoscopic-total-mesometrial-resection-for-early-stage-cervical-cancer-a-multicentric-study
#8
Alessandro Lucidi, Swetlana Windemut, Marco Petrillo, Margherita Dessole, Giulio Sozzi, Giuseppe Filiberto Vercellino, Kaven Baessler, Giuseppe Vizzielli, Jalid Sehouli, Giovanni Scambia, Vito Chiantera
OBJECTIVES: This multicentric retrospective study investigates the early and long-term self-reported urinary, bowel, and sexual dysfunctions in early-stage cervical cancer patients who submitted to laparoscopic total mesometrial resection (L-TMMR), total laparoscopic radical hysterectomy, vaginal-assisted laparoscopic radical hysterectomy, and laparoscopic-assisted radical vaginal hysterectomy. METHODS: Cervical cancer patients, FIGO (International Federation of Gynecology and Obstetrics) stage IA2-IB1/IIA1 who submitted to nerve-sparing radical hysterectomy were recruited...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708788/therapy-modalities-prognostic-factors-and-outcome-of-the-primary-cervical-carcinosarcoma-meta-analysis-of-extremely-rare-tumor-of-cervix
#9
Gunsu Kimyon Comert, Osman Turkmen, Alper Karalok, Derman Basaran, Dilek Bulbul, Taner Turan
OBJECTIVE: The aim of this study was to evaluate the prognostic factors, treatment options, and survival outcomes of primary carcinosarcomas of the uterine cervix. METHODS: An electronic search of the literature was conducted from 1951 to February 2017 to identify articles on primary cervical carcinosarcoma. After comprehensive evaluation of case series and case reports, 81 cases were included in the study. RESULTS: The most common clinical FIGO (International Federation of Gynecology and Obstetrics) stage was IB at 53% of cases...
July 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28708208/relationship-between-clinical-toxicities-and-ercc1-rs3212986-and-xrcc3-rs861539-polymorphisms-in-cervical-cancer-patients
#10
Sílvia Soares, Augusto Nogueira, Ana Coelho, Joana Assis, Deolinda Pereira, Isabel Bravo, Rui Medeiros
BACKGROUND: Several studies have suggested that there are single nucleotide polymorphisms (SNPs) that can be considered potential biomarkers in the prognosis and therapeutic response of cancer patients. The present study investigated the association between ERCC1 rs3212986 and XRCC3 rs861539 polymorphisms and clinical toxicities induced by chemoradiotherapy (CRT) in cervical cancer. METHODS: This hospital-based retrospective cohort study included 260 patients with cervical cancer, FIGO stages Ib2-IVa, who underwent CRT (cisplatin)...
July 8, 2017: International Journal of Biological Markers
https://www.readbyqxmd.com/read/28707541/concurrent-weekly-cisplatin-versus-triweekly-cisplatin-with-radiotherapy-for-locally-advanced-squamous-cell-carcinoma-of-the-cervix-a-retrospective-analysis-from-a-single-institution
#11
Yoshino Kinjyo, Yutaka Nagai, Takafumi Toita, Wataru Kudaka, Takuro Ariga, Yuko Shimoji, Tadaharu Nakasone, Yusuke Taira, Yoshihisa Arakaki, Tomoko Nakamoto, Akihiko Wakayama, Takuma Ooyama, Hitoshi Maemoto, Joichi Heianna, Yoichi Aoki
OBJECTIVES: To compare patients with cervical cancer who were primarily treated with concurrent chemoradiotherapy (CCRT) using 20 mg/m(2) CCDP for 5 days every 3 weeks with weekly regimens of 40 mg/m(2). METHODS: We retrospectively analyzed 185 patients with Stage IB to IVA squamous cell carcinoma of the cervix who were treated with CCRT between 2005 and 2013 at our hospital. The CCRT regimen consisted of cisplatin at 20 mg/m(2) for 5 days every 3 weeks or 40 mg/m(2) weekly, administered concomitantly with RT...
July 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28700422/cervical-squamous-carcinomas-with-prominent-acantholysis-and-areas-resembling-breast-lobular-carcinoma-an-aggressive-form-of-dedifferentation
#12
Kerry Scott, Gareth Bryson, Jackie Jamison, Michael Coutts, W Glenn McCluggage
There have been occasional reports of primary cervical adenocarcinoma with areas of dedifferentiation resulting in morphologic mimicry of breast lobular carcinoma. We describe 4 cases of primary cervical squamous carcinoma with prominent acantholysis (3 cases), areas resembling breast lobular carcinoma (3 cases) or both (2 cases). All 4 tumors showed positivity with p63 and CK5/6 and 3 of 4 exhibited block-type immunoreactivity with p16. Two of the 4 cases contained high-risk human papillomavirus (types 16 and 18) on molecular testing; of the 2 cases which were human papillomavirus negative, 1 exhibited patchy nonblock immunoreactivity with p16...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28699902/e-cadherin-expression-as-a-prognostic-factor-in-patients-with-ovarian-cancer-a-meta-analysis
#13
Chencheng Dai, Jian Cao, Yu Zeng, Sujuan Xu, Xuemei Jia, Pengfei Xu
The prognostic role of epithelial cadherin (E-cadherin) downregulation in ovarian cancer has been assessed for years while the results remain inconclusive. The aim of our study was to assess this issue. Eligible studies were identified through searches of PubMed, EMBASE and Cochrane Database. In total, 1562 patients from 17 studies were included to assess the association between E-cadherin expression and overall survival/progression-free survival and clinicopathological characteristics of ovarian cancer patients...
June 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28698755/primary-fallopian-tube-carcinoma-a-case-report-and-literature-review
#14
Meral Rexhepi, Elizabeta Trajkovska, Hysni Ismaili, Florin Besimi, Nagip Rufati
BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, and it is very difficult to diagnose preoperatively, because of its non-specific symptomatology. In most cases, it is an intraoperative finding or a histopathological diagnosis. It is a tumour that histologically and clinically resembles epithelial ovarian cancer. CASE PRESENTATION: We are reporting a case of a 62-year-old, postmenopausal women with primary fallopian tube carcinoma of the right fallopian tube in stage IA...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28691425/tolerance-of-combined-radiochemotherapy-in-cervical-cancer-patients
#15
Barbara Izmajłowicz, Małgorzata Rusiecka, Aleksandra Sztuder, Marcin Stępień, Agnieszka Ignatowicz- Pacyna, Beata Słocka- Romaniuk, Zbigniew Mazur, Jan Kornafel
BACKGROUND: Radiochemotherapy in cervical cancer was implemented to clinical practice based on five randomized clinical trials, published at the end of 20th century, which showed improvement in total and symptomless survivals by about 10 to 18 %. The increase of therapeutic index of such treatment can take place only at the advantage of the efficiency over the increase of its toxicity. Thus, it is necessary to monitor treatment reaction during radiochemotherapy. OBJECTIVES: The aim of this study is to assess the acute post-radiation reaction during radiochemotherapy for cervical cancer and the analysis of the reasons of the unplanned course of combined treatment...
June 27, 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28681218/cisplatin-with-dose-dense-paclitaxel-before-and-after-radical-hysterectomy-for-locally-advanced-cervical-cancer-a-prospective-multicenter-phase-ii-trial-with-a-dose-finding-study
#16
Maki Tanioka, Satoshi Yamaguchi, Muneaki Shimada, Shoji Nagao, Kazuhiro Takehara, Masato Nishimura, Satoshi Morita, Shunichi Negoro, Kiyoshi Fujiwara, Junzo Kigawa
The aim of this study is to evaluate the outcome and safety of the multidisciplinary strategy using cisplatin plus dose-dense paclitaxel (dose-dense TP) before and after radical hysterectomy (RH) for stage IB2, IIA2, or IIB patients with cervical cancer. In the dose-finding phase, 12 patients received 3 cycles of cisplatin (75 mg/m(2), day 1) with paclitaxel (70 or 80 mg/m(2), days 1, 8, and 15) every 21 days as neoadjuvant chemotherapy (NAC). In the phase II study, 51 patients received 3 cycles of dose-dense TP at the recommended dose as NAC, and another 2 cycles of the same regimen after RH...
August 2017: Medical Oncology
https://www.readbyqxmd.com/read/28678760/prognostic-value-of-intratumoral-metabolic-heterogeneity-on-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-locally-advanced-cervical-cancer-patients-treated-with-concurrent-chemoradiotherapy
#17
Gun Oh Chong, Won Kee Lee, Shin Young Jeong, Shin-Hyung Park, Yoon Hee Lee, Sang-Woo Lee, Dae Gy Hong, Jae-Chul Kim, Yoon Soon Lee
OBJECTIVE: To evaluate the prognostic value for predicting tumor recurrence of intratumoral metabolic heterogeneity and traditional quantitative metabolic parameters on pre-treatment F-18-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in patients with locally advanced cervical cancer treated with concurrent chemoradiotherapy (CCRT). MATERIALS AND METHODS: Ninety-three patients with biopsy-proven cervical cancer and treated with CCRT (FIGO stage IIB-IV) were enrolled in this study...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28668074/evidence-of-lower-oxygen-reserves-during-labour-in-the-growth-restricted-human-foetus-a-retrospective-study
#18
Silvia Parisi, Clara Monzeglio, Rossella Attini, Marilisa Biolcati, Bianca Masturzo, Manuela Mensa, Marina Mischinelli, Eleonora Pilloni, Tullia Todros
BACKGROUND: The aim of the present study is to test the hypothesis that Growth Restricted foetuses (FGR) have the tendency to develop more pathological cardiotocograpic tracings during labour than do appropriate for gestational age foetuses and that there is a shorter time lapse from the beginning of labour and the advent of a pathological cardiotocograpic tracing. METHODS: The study was carried out at the Maternal-Foetal Medicine Unit of the Sant'Anna University Hospital, Turin, Italy...
July 1, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28667682/dedifferentiated-carcinoma-with-clear-cell-carcinoma-of-the-endometrium-a-case-report
#19
Seung Eun Lee, Ha Young Park, Seung-Hyuk Shim, Wook Youn Kim
Endometrial dedifferentiated carcinoma consists of a combination of undifferentiated and differentiated carcinomas. To date, clear cell carcinoma components in endometrial dedifferentiated carcinoma have not been reported. We report the first case of endometrial dedifferentiated carcinoma with clear cell carcinoma in a 58-year-old woman. The uterine corpus was completely replaced and enlarged by a heterogeneous mass. The endometrial cut surface showed a yellowish papillary growing mass involving endometrium and deeper myometrium...
June 30, 2017: Pathology International
https://www.readbyqxmd.com/read/28666421/dickkopf-4-is-frequently-overexpressed-in-epithelial-ovarian-carcinoma-and-promotes-tumor-invasion
#20
Shizhuo Wang, Heng Wei, Shulan Zhang
BACKGROUND: Dickkopf-4 (DKK4), a member of DKK family, appears to be a divergent protein. It remained multi-biological functions in carcinogenesis. The effect of DKK4 on the ovarian cancer cells remains unclear. This study detected the clinical significance of DKK4 in epithelial ovarian cancer (EOC) patients and its role in invasion. METHODS: QRT-PCR and western blot analysis were used to examine the levels of DKK4 mRNA and protein in 33 EOC tissues and 33 benign ovarian tumors...
June 30, 2017: BMC Cancer
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