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https://www.readbyqxmd.com/read/28526027/description-of-inter-institutional-referrals-after-admission-for-labor-and-delivery-a-prospective-population-based-cohort-study-in-rural-maharashtra-india
#1
Archana B Patel, Amber Abhijeet Prakash, Camille Raynes-Greenow, Yamini V Pusdekar, Patricia L Hibberd
BACKGROUND: In 2008, the Indian government introduced financial assistance to encourage health facility deliveries. Facility births have increased, but maternal and neonatal morbidity and mortality have not decreased raising questions about the quality of care provided in facilities and access to a quality referral system. We evaluated the potential role of inter-institutional transfers of women admitted for labor and delivery on adverse maternal and neonatal outcomes in an ongoing prospective, population-based Maternal and Newborn Health Registry in Central India...
May 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28521019/a-whole-system-approach-to-improving-mortality-associated-with-acute-kidney-injury
#2
Thangavelu Chandrasekar, Asheesh Sharma, Lucinda Tennent, Christopher Wong, Peter Chamberlain, Kottarathil A Abraham
BACKGROUND: Acute kidney injury (AKI) is in the main managed by non-nephrologists, many who feel challenged by or lack awareness of the complexity that the renal element adds to their patients' care. National reports have raised major concerns about the quality of care and have predicted that mortality reductions of 30% are achievable with good medical practice. AIM: This quality improvement project evaluated whether a whole system approach could improve outcomes for patients with AKI...
May 18, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28516797/blood-glucose-and-insulin-and-correlation-of-slc25a13-mutations-with-biochemical-changes-in-niccd-patients
#3
Chun-Ting Lu, Qi-Ping Shi, Ze-Jian Li, Jiong Li, Lie Feng
Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is a hereditary metabolic disease arising from biallelic mutations of SLC25A13. This study aimed to explore the characteristics of fasting blood glucose (FBG), fasting insulin (FINS) and C-peptide (C-P) levels in NICCD infants, analyze their SLC25A13 genetic mutations and further discuss the correlation between SLC25A13 genetic mutations and biochemical changes. Seventy-two cases of infants with cholestasis disease were gathered. Among them, 36 cases with NICCD diagnosis were case group...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28512457/the-25-26-nt-small-rnas-in-phytophthora-parasitica-are-associated-with-efficient-silencing-of-homologous-endogenous-genes
#4
Jinbu Jia, Wenqin Lu, Chengcheng Zhong, Ran Zhou, Junjie Xu, Wei Liu, Xiuhong Gou, Qinhu Wang, Junliang Yin, Cheng Xu, Weixing Shan
Small RNAs (sRNAs) are important non-coding RNA regulators, playing key roles in developmental regulation, transposon suppression, environmental response, host-pathogen interaction and other diverse biological processes. However, their roles in oomycetes are poorly understood. Here, we performed sRNA sequencing and RNA sequencing of Phytophthora parasitica at stages of vegetative growth and infection of Arabidopsis roots to examine diversity and function of sRNAs in P. parasitica, a model hemibiotrophic oomycete plant pathogen...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28511118/simultaneous-determination-of-selective-serotonin-reuptake-inhibitors-and-their-main-metabolites-in-human-breast-milk-by-liquid-chromatography-electrospray-mass-spectrometry
#5
Etienne Weisskopf, Alice Panchaud, Kim An Nguyen, Delphine Grosjean, Jean-Michel Hascoët, Chantal Csajka, Chin B Eap, Nicolas Ansermot
A bioanalytical method by high performance liquid chromatography coupled to electrospray mass spectrometry (HPLC-ESI-MS), adapted from a previously published method in plasma, was validated in breast milk for the simultaneous quantification of all antidepressants belonging to the class of selective serotonin reuptake inhibitors (citalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) and their major metabolites (desmethylcitalopram and norfluoxetine). Milk samples (250μl) first underwent protein precipitation followed by solid-phase extraction on a reversed phase/cation exchange sorbent...
April 27, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28508079/a-twofold-quantum-delayed-choice-experiment-in-a-superconducting-circuit
#6
Ke Liu, Yuan Xu, Weiting Wang, Shi-Biao Zheng, Tanay Roy, Suman Kundu, Madhavi Chand, Arpit Ranadive, Rajamani Vijay, Yipu Song, Luming Duan, Luyan Sun
Wave-particle complementarity lies at the heart of quantum mechanics. To illustrate this mysterious feature, Wheeler proposed the delayed-choice experiment, where a quantum system manifests the wave- or particle-like attribute, depending on the experimental arrangement, which is made after the system has entered the interferometer. In recent quantum delayed-choice experiments, these two complementary behaviors were simultaneously observed with a quantum interferometer in a superposition of being closed and open...
May 2017: Science Advances
https://www.readbyqxmd.com/read/28506420/update-on-the-role-of-ultrasound-guided-radiofrequency-ablation-for-thyroid-nodule-treatment
#7
Maija Radzina, Vito Cantisani, Madara Rauda, Michael Bachmann Nielsen, Caroline Ewertsen, Ferdinando D'Ambrosio, Peteris Prieditis, Salvatore Sorrenti
Thyroid nodules can be frequently detected in general population, most of them are benign, however malignant cases are rising in the past decades. Ultrasound (US) is the most common imaging modality to assess thyroid nodular lesions, plan patient work-up and guide minimally invasive treatment. The present review paper has been researched to evaluate the current status of radiofrequency ablation (RFA) treatment in order to evaluate indications, techniques, complications, limitations and outcome assessment in benign solid, partially cystic nodules and recurrent malignant nodules...
May 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28505006/myopericytomatosis-clinicopathologic-analysis-of-11-cases-with-molecular-identification-of-recurrent-pdgfrb-alterations-in-myopericytomatosis-and-myopericytoma
#8
Yin P Hung, Christopher D M Fletcher
Myopericytoma is a benign tumor of concentrically distributed perivascular myoid cells. Its molecular basis and relationship with myofibroma/myofibromatosis and other pericytic tumors are not fully understood. In our consultation/surgical files of over 1000 myopericytic lesions, we identified 11 cases with diffuse dermal/subcutaneous involvement by microscopic myopericytomatous nodules, a phenomenon we have termed myopericytomatosis. Myopericytomatosis affected mostly adults (female:male=8:3; median age, 37 y; range, 9 to 63 y) in the lower extremities (foot/ankle, 5; calf, 3; knee, 1; thigh, 1; neck, 1) over months to 25 years, ranging from 1...
May 12, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28504862/poly-adenine-modulated-dna-conformation-monitored-with-sers-on-multibranched-gold-nanoparticle-and-its-sensing-application
#9
Huangxian Ju, Jingxing Guo, Yunlong Chen, Yongjia Jiang
This work proposes a facile way to modulate the conformation of DNA from "Lie Down" to "Stand Up" on the surface of multibranched gold nanoparticles (AuNS), which is realized by regulating the length of polyA linked to the DNA sequence and/or the hybridization of this sequence with target DNA, and can be monitored with Raman signal owing to the excellent performance of AuNS as SERS substrate and the distance change between Raman reporter and the substrate. The probable mechanism that depends on the repulsion of polyA to the sequence and the tip assembly has been also raised by theoretical simulation with finite difference time domain method...
May 15, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28503215/fast-determination-of-structurally-cohesive-subgroups-in-large-networks
#10
Robert S Sinkovits, James Moody, B Tolga Oztan, Douglas R White
Structurally cohesive subgroups are a powerful and mathematically rigorous way to characterize network robustness. Their strength lies in the ability to detect strong connections among vertices that not only have no neighbors in common, but that may be distantly separated in the graph. Unfortunately, identifying cohesive subgroups is a computationally intensive problem, which has limited empirical assessments of cohesion to relatively small graphs of at most a few thousand vertices. We describe here an approach that exploits the properties of cliques, k-cores and vertex separators to iteratively reduce the complexity of the graph to the point where standard algorithms can be used to complete the analysis...
November 2016: Journal of Computational Science
https://www.readbyqxmd.com/read/28502972/distribution-innervation-and-cellular-organization-of-taste-buds-in-the-sea-catfish-plotosus-japonicus
#11
Tatsufumi Nakamura, Naoki Matsuyama, Masato Kirino, Masanori Kasai, Sadao Kiyohara, Takanori Ikenaga
The gustatory system of the sea catfish Plotosus japonicus, like that of other catfishes, is highly developed. To clarify the details of the morphology of the peripheral gustatory system of Plotosus, we used whole-mount immunohistochemistry to investigate the distribution and innervation of the taste buds within multiple organs including the barbels, oropharyngeal cavity, fins (pectoral, dorsal, and caudal), and trunk. Labeled taste buds could be observed in all the organs examined. The density of the taste buds was higher along the leading edges of the barbels and fins; this likely increases the chance of detecting food...
May 13, 2017: Brain, Behavior and Evolution
https://www.readbyqxmd.com/read/28501219/headspace-single-drop-microextraction-coupled-with-microvolume-fluorospectrometry-for-highly-sensitive-determination-of-bromide
#12
Adrián García-Figueroa, Francisco Pena-Pereira, Isela Lavilla, Carlos Bendicho
This work reports on the development of a novel methodology for bromide determination by combining headspace single-drop microextraction with microvolume fluorospectrometry. The method lies in the in situ generation of bromine, transfer of the volatile to the headspace and trapping/reaction onto a fluorescein-containing aqueous drop exposed to the gas phase. The decrease in the fluorescence intensity enabled the determination of bromide without dilution of the enriched microdrop. Experimental parameters influencing the performance of the method, namely, fluorescence parameters, extractant phase composition, bromine generation conditions and microextraction time, were evaluated and controlled...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28486694/differential-microrna-expression-in-cultured-palatal-fibroblasts-from-infants-with-cleft-palate-and-controls
#13
Christian Schoen, Jeffrey C Glennon, Shaghayegh Abghari, Marjon Bloemen, Armaz Aschrafi, Carine E L Carels, Johannes W Von den Hoff
Background: The role of microRNAs (miRNAs) in animal models of palatogenesis has been shown, but only limited research has been carried out in humans. To date, no miRNA expression study on tissues or cells from cleft palate patients has been published. We compared miRNA expression in palatal fibroblasts from cleft palate patients and age-matched controls. Material and Methods: Cultured palatal fibroblasts from 10 non-syndromic cleft lip and palate patients (nsCLP; mean age: 18 ± 2 months), 5 non-syndromic cleft palate only patients (nsCPO; mean age: 17 ± 2 months), and 10 controls (mean age: 24 ± 5 months) were analysed with next-generation small RNA sequencing...
May 9, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/28484763/electron-stimulated-desorption-from-condensed-pyrimidine-and-pyridazine
#14
L Ellis-Gibbings, A D Bass, P Cloutier, G García, L Sanche
Low energy electron (LEE) interactions and the formation of transient negative ions play a dominant role in radiation-induced dissociation of condensed-phase biomolecules (e.g. in radiotherapy). Here we present data on the LEE-induced dissociation and desorption of the DNA/RNA-base and radiosensitizing agent analogues pyrimidine and pyridazine. Vapors of each molecule were condensed on either a Pt or Ar substrate to form a multilayer film or a submonolayer molecular target, respectively. These were irradiated with electrons of 0-80 eV and the desorbing anionic and cationic fragments analysed via time of flight mass spectrometry...
May 9, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28481252/wearable-contactless-respiration-sensor-based-on-multi-material-fibers-integrated-into-textile
#15
Philippe Guay, Stepan Gorgutsa, Sophie LaRochelle, Younes Messaddeq
In this paper, we report on a novel sensor for the contactless monitoring of the respiration rate, made from multi-material fibers arranged in the form of spiral antenna (2.45 GHz central frequency). High flexibility of the used composite metal-glass-polymer fibers permits their integration into a cotton t-shirt without compromising comfort or restricting movement of the user. At the same time, change of the antenna geometry, due to the chest expansion and the displacement of the air volume in the lungs, is found to cause a significant shift of the antenna operational frequency, thus allowing respiration detection...
May 6, 2017: Sensors
https://www.readbyqxmd.com/read/28476759/hla-a-24-02-as-a-common-risk-factor-for-antiepileptic-drug-induced-cutaneous-adverse-reactions
#16
Yi-Wu Shi, Fu-Li Min, Dong Zhou, Bin Qin, Juan Wang, Fa-Yun Hu, Ying-Kit Cheung, Jin-Hua Zhou, Xiang-Shu Hu, Jue-Qian Zhou, Lie-Min Zhou, Zhong-Zheng Zheng, Jie Pan, Na He, Zhi-Sheng Liu, Yun-Qi Hou, Kheng-Seang Lim, Yang-Mei Ou, Amy Hui-Ping Khor, Ching-Ching Ng, Bi-Jun Mao, Xiao-Rong Liu, Bing-Mei Li, Yao-Yun Kuan, Yong-Hong Yi, Xue-Lian He, Xiao-Yan Deng, Tao Su, Patrick Kwan, Wei-Ping Liao
OBJECTIVE: To investigate the involvement of human leukocyte antigen (HLA) loci in aromatic antiepileptic drug-induced cutaneous adverse reactions. METHODS: A case-control study was performed to detect HLA loci involved in aromatic antiepileptic drug-induced Stevens-Johnson syndrome in a southern Han Chinese population. Between January 1, 2006, and December 31, 2015, 91 cases of Stevens-Johnson syndrome induced by aromatic antiepileptic drugs and 322 matched drug-tolerant controls were enrolled from 8 centers...
May 5, 2017: Neurology
https://www.readbyqxmd.com/read/28470652/laboratory-diagnostics-of-antiphospholipid-syndrome
#17
Vittorio Pengo, Elisa Bison, Gentian Denas, Seena Padayattil Jose, Giacomo Zoppellaro, Alessandra Banzato
Diagnosis of antiphospholipid syndrome (APS) lies in the recognition of antiphospholipid antibodies (aPL). As standardization of tests for the detection of aPL is far from being optimal and reference material is not available, inappropriate diagnoses of APS are not unusual. In the last few years, the concept of triple test positivity has emerged as a useful tool to identify patients with APS. Clinical studies on patients and carriers of triple positivity clearly show that these individuals are at high risk of thromboembolic events and pregnancy loss...
May 3, 2017: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/28463200/correlation-based-tracker-level-fusion-for-robust-visual-tracking
#18
Madan Rapuru, Sumithra Kakanuru, Pallavi Venugopal M, Deepak Mishra, Gorthi R F Subrahmanyam
Although visual object tracking algorithms are capable of handling various challenging scenarios individually, none of them are robust enough to handle all the challenges simultaneously. For any online tracking by detection method the key issue lies in detecting the target over the whole frame and updating systematically a target model based on the last detected appearance to avoid the drift phenomenon. This paper aims at proposing a novel robust tracking algorithm by fusing the frame level detection strategy of Tracking, Learning & Detection with the systematic model update strategy of Kernelized Correlation Filter tracker...
April 28, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28453973/determinants-of-children-s-exposure-to-pyrethroid-insecticides-in-western-france
#19
Philippe Glorennec, Tania Serrano, Morgane Fravallo, Charline Warembourg, Christine Monfort, Sylvaine Cordier, Jean-François Viel, Florent Le Gléau, Barbara Le Bot, Cécile Chevrier
Pyrethroids are insecticides frequently used in agriculture and in the home; exposure occurs through dietary and non-dietary pathways, including indoor and outdoor environmental contamination. Our objective was to study the potential determinants of pyrethroid metabolite concentrations measured in children's urine samples and in the dust of their homes. Specifically, we measured urinary metabolites from morning spot samples of 245 six-year-old children living in Brittany (France) in 2009-2012 and from dust vacuumed from the floor of their homes...
April 25, 2017: Environment International
https://www.readbyqxmd.com/read/28451046/-uncommon-mammary-type-myofibroblastoma-unlike-any-other-about-a-case
#20
Othmane Lahbali, Amine Azami, Mohammed Tbouda, Adil Elyamine, Fouad Zouaidia, Najat Mahassini
Mammary-type myofibroblastoma (MTMF) is a rare benign mesenchymal tumor, initially detected in the breast. Its diagnosis is based on a spectrum of clinical, radiological and possibly histological parameters. We here report the rare case of a 50 year old male patient with mammary-type myofibroblastoma located in the axillary region. The peculiarity of our case lies in the presence of numerous mitoses and this was rarely described in the literature. The aim of our case study was to raise the problem of differential diagnosis of this rare tumor...
2017: Pan African Medical Journal
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