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Lie detection

Federico Davini, Sara Ricciardi, Carmelina Cristina Zirafa, Ilenia Cavaliere, Gaetano Romano, Franca Melfi
Background: The incidental detection of solitary pulmonary nodule (SPN) is currently increasing due to the widespread use of computed tomography (CT) during the follow up in oncological patients or in screening trials. A quick and definitive histological diagnosis of these nodes is mandatory as, in case of primitive lung cancer, an early detection could improve both surgical results and prognosis. The minimally invasive pulmonary resection (MIPR) is the gold standard procedure for diagnosis and treatment of small lung nodules, but it can be difficult to localize deep nonpalpable nodes that lie in the lung parenchyma...
2018: Journal of Visualized Surgery
Lie Yao, Jichun Gu, Yishen Mao, Xinju Zhang, Xiaoyi Wang, Chen Jin, Deliang Fu, Ji Li
The main focus of the present study was to evaluate whether ABC transporter family promoter methylation predicted multidrug resistance in gemcitabine-resistant cancer cell lines (BxPC-3/Gem and PANC-1/Gem). Using low concentrations of gemcitabine, the cell lines acquired drug resistance with different initial gemcitabine concentrations. A novel technology, methylation-sensitive high-resolution melting, was used to monitor the dynamic changes of ABC transporter family promoter methylation, including ATP binding cassette subfamily B member 1 (ABCB1), ATP binding cassette subfamily C (ABCC) and ATP binding cassette subfamily G member 2 (ABCG2) mRNA expression...
April 2018: Oncology Letters
Barbara Diana, Valentino Zurloni, Massimiliano Elia, Cesare Cavalera, Olivia Realdon, Gudberg K Jonsson, M Teresa Anguera
Deception has evolved to become a fundamental aspect of human interaction. Despite the prolonged efforts in many disciplines, there has been no definite finding of a univocally "deceptive" signal. This work proposes an approach to deception detection combining cognitive load manipulation and T-pattern methodology with the objective of: (a) testing the efficacy of dual task-procedure in enhancing differences between truth tellers and liars in a low-stakes situation; (b) exploring the efficacy of T-pattern methodology in discriminating truthful reports from deceitful ones in a low-stakes situation; (c) setting the experimental design and procedure for following research...
2018: Frontiers in Psychology
Kristina H Haugaa, Øyvind H Lie
No abstract text is available yet for this article.
March 12, 2018: JACC. Cardiovascular Imaging
Per Peetz Nielsen, Ilaria Fontana, Karen Helle Sloth, Marcella Guarino, Harry Blokhuis
To validate the accuracy of 2 commercially available activity loggers in determining lying, standing, walking, and number of steps in dairy cows, 30 cows were fitted with the CowScout Leg (GEA Farm Technologies, Bönen, Germany) system and the IceTag (IceRobotics Ltd., Edinburgh, Scotland) system. The CowScout Leg logger reports standing and lying in 15-min periods, whereas the IceTag logger reports standing and lying every second. To make data comparable, the IceTag data were therefore also summarized over 15-min periods corresponding to the paired CowScout Leg sensor...
March 14, 2018: Journal of Dairy Science
Roland Opfer, Ann-Christin Ostwaldt, Christine Walker-Egger, Praveena Manogaran, Maria Pia Sormani, Nicola De Stefano, Sven Schippling
BACKGROUND: Measurements of brain volume loss (BVL) in individual patients are currently discussed controversially. One concern is the impact of short-term biological noise, like hydration status. METHODS: Three publicly available reliability MRI datasets with scan intervals of days to weeks were used. An additional cohort of 60 early relapsing multiple sclerosis (MS) patients with MRI follow-ups was analyzed to test whether after 1 year pathological BVL is detectable in a relevant fraction of MS patients...
March 16, 2018: Journal of Neurology
Ben A Wagstaff, Edward S Hems, Martin Rejzek, Jennifer Pratscher, Elliot Brooks, Sakonwan Kuhaudomlarp, Ellis C O'Neill, Matthew I Donaldson, Steven Lane, John Currie, Andrew M Hindes, Gill Malin, J Colin Murrell, Robert A Field
Prymnesium parvum is a toxin-producing microalga that causes harmful algal blooms globally, which often result in large-scale fish kills that have severe ecological and economic implications. Although many toxins have previously been isolated from P. parvum , ambiguity still surrounds the responsible ichthyotoxins in P. parvum blooms and the biotic and abiotic factors that promote bloom toxicity. A major fish kill attributed to P. parvum occurred in Spring 2015 on the Norfolk Broads, a low-lying set of channels and lakes (Broads) found on the East of England...
March 14, 2018: Biochemical Society Transactions
Chengxin Zhang, Wei Zheng, Peter L Freddolino, Yang Zhang
Homology-based transferal remains the major approach to computational protein function annotations, but it becomes increasingly unreliable when the sequence identity between query and template decreases below 30%. We propose a novel pipeline, MetaGO, to deduce Gene Ontology attributes of proteins by combining sequence homology-based annotation with low-resolution structure prediction and comparison, and partner's-homology based protein-protein network mapping. The pipeline was tested on a large-scale set of 1000 non-redundant proteins from the CAFA3 experiment...
March 10, 2018: Journal of Molecular Biology
Morteza Modarresi Asem, Iman Sheikh Oveisi, Mona Janbozorgi
Retinal blood vessels indicate some serious health ramifications, such as cardiovascular disease and stroke. Thanks to modern imaging technology, high-resolution images provide detailed information to help analyze retinal vascular features before symptoms associated with such conditions fully develop. Additionally, these retinal images can be used by ophthalmologists to facilitate diagnosis and the procedures of eye surgery. A fuzzy noise reduction algorithm was employed to enhance color images corrupted by Gaussian noise...
July 2018: Journal of Medical Imaging
You-Zhen Feng, Xiao-Qiao Chen, Juan Yu, Xiao-Ling Liu, Zhong-Yuan Cheng, Wei-Wei Ren, Lie Feng, Xiang-Ran Cai
PURPOSE: The purpose of this study was to evaluate the utility of intravoxel incoherent motion diffusion-weighted imaging (IVIM DWI) parameters in identifying early renal function changes in diabetics. METHODS: A total of 40 patients with type 2 diabetes mellitus and 20 healthy control subjects underwent multiple b value DWI. The diabetic patients were stratified into two groups based on albuminuria category: NAU (normal to mildly increased albuminuria; ACR < 30 mg/g) and MAU (moderately increased albuminuria; 30 ≤ ACR < 300 mg/g)...
March 10, 2018: Abdominal Radiology
Antonio Reis de Sá Junior, Arthur Guerra de Andrade, Laura Helena Andrade, Clarice Gorenstein, Yuan-Pang Wang
BACKGROUND: This study examines the response pattern of depressive symptoms in a nationwide student sample, through item analyses of a rating scale by both classical test theory (CTT) and item response theory (IRT). METHODS: The 21-item Beck Depression Inventory-II (BDI-II) was administered to 12,711 college students. First, the psychometric properties of the scale were described. Thereafter, the endorsement probability of depressive symptom in each scale item was analyzed through CTT and IRT...
March 3, 2018: Journal of Affective Disorders
Kalyani Khanra, Indranil Choudhuri, Nandan Bhattacharyya
Background: DNA polymerase β (pol β) is a key enzyme of base excision repair pathway. It is a 1-kb gene consisting of 14 exons. Its catalytic part lies between exon 8 and exon 14. Exon 12 has a role in deoxyribonucleotide triphosphate selection for nucleotide transferase activity. Methods: Genomic DNA was isolated from ovarian carcinoma samples. Single strand conformation polymorphism method was used to detect mutation in genomic DNA. Results: Twenty-four patients of the 152 pair of tumor samples (15...
March 10, 2018: Iranian Biomedical Journal
Xu Steven Xu, Min Yuan, Hao Zhu, Yaning Yang, Hui Wang, Honghui Zhou, Jinfeng Xu, Liping Zhang, Jose Pinheiro
OBJECTIVE: To clarify the hypothesis tests associated with the full covariate modeling (FCM) approach in population pharmacokinetic (PPK) analysis, investigate the potential impact of multiplicity in PPK analysis, and evaluate simultaneous confidence intervals (SCI) as an approach to control multiplicity. METHODS: Clinical trial simulations were performed using a simple one-compartment PK model. Different numbers of covariates, sample sizes, effect sizes of covariates, and correlations among covariates were explored...
March 9, 2018: British Journal of Clinical Pharmacology
Øivind Skare, Rolv T Lie, Øystein A Haaland, Miriam Gjerdevik, Julia Romanowska, Håkon K Gjessing, Astanand Jugessur
Background: Although both the mother's and father's alleles are present in the offspring, they may not operate at the same level. These parent-of-origin (PoO) effects have not yet been explored on the X chromosome, which motivated us to develop new methods for detecting such effects. Orofacial clefts (OFCs) exhibit sex-specific differences in prevalence and are examples of traits where a search for various types of effects on the X chromosome might be relevant. Materials and Methods: We upgraded our R-package Haplin to enable genome-wide analyses of PoO effects, as well as power simulations for different statistical models...
2018: Frontiers in Genetics
Lukas Everding, Jörg Conradt
In order to safely navigate and orient in their local surroundings autonomous systems need to rapidly extract and persistently track visual features from the environment. While there are many algorithms tackling those tasks for traditional frame-based cameras, these have to deal with the fact that conventional cameras sample their environment with a fixed frequency. Most prominently, the same features have to be found in consecutive frames and corresponding features then need to be matched using elaborate techniques as any information between the two frames is lost...
2018: Frontiers in Neurorobotics
Raquel Bello-Morales, Beatriz Praena, Carmen de la Nuez, María Teresa Rejas, Milagros Guerra, Marcos Galán, Manuel Izquierdo, Víctor Calvo, Claude Krummenacher, José Antonio López-Guerrero
Herpes simplex virus type 1 (HSV-1) is a neurotropic pathogen that can infect many types of cells and establishes latent infections in neurons of sensory ganglia. In some cases, the virus spreads into the CNS causing encephalitis or meningitis. Cells infected with several different types of viruses may secrete microvesicles containing viral proteins and RNAs. In some instances, extracellular microvesicles harboring infectious virus have been found. Here we describe the features of shedding microvesicles released by the human oligodendroglial HOG cell line infected with HSV-1 and their participation in the viral cycle...
March 7, 2018: Journal of Virology
Pankaj D Mehta, Bruce A Patrick, Marc Barshatzky, Sangita P Mehta, Janusz Frackowiak, Bozena Mazur-Kolecka, Jerzy Wegiel, Thomas Wisniewski, David L Miller
N-terminally truncated pyroglutamate amyloid-β (Aβ) peptide starting at position 3 represents a significant fraction of Aβ peptides (pE3-Aβ) in amyloid plaques of postmortem brains from patients with Alzheimer's disease (AD) and older persons with Down syndrome (DS). Studies in transgenic mouse models of AD also showed that pE3-Aβ is a major component of plaques, and mouse monoclonal antibody to pE3-Aβ appears to be a desirable therapeutic agent for AD. Since small peptides do not typically elicit a good immune response in mice, but do so favorably in rabbits, our aims were to generate and partially characterize a rabbit monoclonal antibody (RabmAb) to pE3-Aβ...
August 22, 2018: Journal of Alzheimer's Disease: JAD
Yuan Zhang, Shiqing Sun, Qi Xu, Weihua Feng, Haisong Chen
RATIONALE AND OBJECTIVES: The posterior inferior cerebellar artery aneurysm (PICAA), especially distal PICAA, is easily missed by a doctor, leading to misdiagnosis and treatment delays. The objective of this article is to report the computed tomography angiography (CTA) presentations of 30 cases of PICAA proved by digital subtraction angiography (DSA) or surgical operation, and analyze the causes of misdiagnosis of PICAA by CTA. MATERIALS AND METHODS: Thirty cases of patients with PICAA that were proved by DSA or surgical operation were included in this study, all of whom underwent CTA before surgical procedure...
March 1, 2018: Academic Radiology
Itsaso Colás, Almudena Capilla, Ana B Chica
The relation between attention and consciousness is a highly debated topic in Cognitive Neuroscience. Although there is an agreement about their relationship at the functional level, there is still no consensus about how these two cognitive processes interact at the neural level. According to the gateway hypothesis (Posner, 1994), attention filters the information accessing to consciousness, resulting in both neural and functional modulations. Contrary to this idea, the cumulative influence hypothesis (Tallon-Baudry, 2012) proposes that both attention and consciousness independently impact decision processes about the perception of stimuli...
March 1, 2018: Neuropsychologia
Zhihua Wang, Kai Wang, Yuan Dang, Xiaojuan Ouyang, Fan Zhang, Wenyuan Wang, Lie Wang, Qiaojia Huang
BACKGROUND: The current study determined the expression and clinical value of lncRNA AC010761.9 in human gastric adenocarcinoma (GA). METHODS: Real-time quantitative reverse transcription (qRT)-PCR was used to detect the level of lncRNA expression in 145 GA tissues and three GA cell lines, and the correlation between its level and clinicopathologic characteristics and potential corresponding mRNA of TNF receptor-associated factor 4 gene (TRAF4) was then evaluated...
March 2, 2018: World Journal of Surgical Oncology
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