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Michael Bourke

Josephine M Bryant, Dorothy M Grogono, Daniela Rodriguez-Rincon, Isobel Everall, Karen P Brown, Pablo Moreno, Deepshikha Verma, Emily Hill, Judith Drijkoningen, Peter Gilligan, Charles R Esther, Peadar G Noone, Olivia Giddings, Scott C Bell, Rachel Thomson, Claire E Wainwright, Chris Coulter, Sushil Pandey, Michelle E Wood, Rebecca E Stockwell, Kay A Ramsay, Laura J Sherrard, Timothy J Kidd, Nassib Jabbour, Graham R Johnson, Luke D Knibbs, Lidia Morawska, Peter D Sly, Andrew Jones, Diana Bilton, Ian Laurenson, Michael Ruddy, Stephen Bourke, Ian C J W Bowler, Stephen J Chapman, Andrew Clayton, Mairi Cullen, Owen Dempsey, Miles Denton, Maya Desai, Richard J Drew, Frank Edenborough, Jason Evans, Jonathan Folb, Thomas Daniels, Helen Humphrey, Barbara Isalska, Søren Jensen-Fangel, Bodil Jönsson, Andrew M Jones, Terese L Katzenstein, Troels Lillebaek, Gordon MacGregor, Sarah Mayell, Michael Millar, Deborah Modha, Edward F Nash, Christopher O'Brien, Deirdre O'Brien, Chandra Ohri, Caroline S Pao, Daniel Peckham, Felicity Perrin, Audrey Perry, Tania Pressler, Laura Prtak, Tavs Qvist, Ali Robb, Helen Rodgers, Kirsten Schaffer, Nadia Shafi, Jakko van Ingen, Martin Walshaw, Danie Watson, Noreen West, Joanna Whitehouse, Charles S Haworth, Simon R Harris, Diane Ordway, Julian Parkhill, R Andres Floto
Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M...
November 11, 2016: Science
Jack M Bourke, Michael O'Sullivan, Muhammad A Khattak
New immunotherapies have significantly improved survival in certain advanced cancers in recent years, particularly metastatic melanoma and lung cancer. The most effective of these therapies are the immune checkpoint inhibitors (ICIs) such as ipilimumab, nivolumab and pembrolizumab. The use of ICIs will continue to increase in the coming years as evidence of their benefit in a range of other cancers builds. ICIs are associated with novel immune-related adverse events (irAEs), which can involve a wide range of organs...
November 7, 2016: Medical Journal of Australia
Colin J Rees, Roisin Bevan, Katharina Zimmermann-Fraedrich, Matthew D Rutter, Douglas Rex, Evelien Dekker, Thierry Ponchon, Michael Bretthauer, Jaroslaw Regula, Brian Saunders, Cesare Hassan, Michael J Bourke, Thomas Rösch
Colonoscopy is a widely performed procedure with procedural volumes increasing annually throughout the world. Many procedures are now performed as part of colorectal cancer screening programmes. Colonoscopy should be of high quality and measures of this quality should be evidence based. New UK key performance indicators and quality assurance standards have been developed by a working group with consensus agreement on each standard reached. This paper reviews the scientific basis for each of the quality measures published in the UK standards...
October 8, 2016: Gut
Nicholas G Burgess, Michael J Bourke
No abstract text is available yet for this article.
October 2016: Endoscopy International Open
Donna B Taylor, Anita G Bourke, Max M Hobbs, Glenys Dixon, Michael Phillips, Christobel M Saunders
No abstract text is available yet for this article.
October 2016: ANZ Journal of Surgery
John Wakerman, John Humphreys, Lisa Bourke, Terry Dunbar, Michael Jones, Timothy A Carey, Steven Guthridge, Deborah Russell, David Lyle, Yuejen Zhao, Lorna Murakami-Gold
BACKGROUND: Remote Australia is a complex environment characterized by workforce shortages, isolated practice, a large resident Indigenous population, high levels of health need, and limited access to services. In recent years, there has been an increasing trend of utilizing a short-term visiting (fly-in/fly-out) health workforce in many remote areas. However, there is a dearth of evidence relating to the impact of this transitory workforce on the existing resident workforce, consumer satisfaction, and the effectiveness of current services...
October 3, 2016: JMIR Research Protocols
Luke B Hesson, Benedict Ng, Peter Zarzour, Sameer Srivastava, Chau-To Kwok, Deborah Packham, Andrea C Nunez, Dominik Beck, Regina Ryan, Ashraf Dower, Caroline E Ford, John Pimanda, Mathew A Sloane, Nicholas J Hawkins, Michael J Bourke, Jason W H Wong, Robyn L Ward
: Laterally spreading tumors (LSTs) are colorectal adenomas that develop into extremely large lesions with predominantly slow progression to cancer depending on lesion subtype. Comparing and contrasting the molecular profiles of LSTs and colorectal cancer (CRCs) offers an opportunity to delineate key molecular alterations that drive malignant transformation in the colorectum. In a discovery cohort of 11 LSTs and paired normal mucosa, we performed a comprehensive and unbiased screen of the genome, epigenome and transcriptome followed by bioinformatics integration of these data and validation in an additional 84 large benign colorectal lesions...
September 26, 2016: Molecular Cancer Research: MCR
James A L Brown, Emer Bourke, Leif A Eriksson, Michael J Kerin
Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de-acetyltransferases (HDAC), and are exciting targets for drug development. Importantly, dysfunctional acetylation has been implicated in numerous diseases, including cancer. Within the HAT superfamily the MYST family holds particular interest, as its members are directly involved in the DNA damage response and repair pathways and crucially, several members have been shown to be down-regulated in common cancers (such as breast and prostate)...
August 15, 2016: Biochemical Society Transactions
Nicholas G Burgess, Milan S Bassan, Duncan McLeod, Stephen J Williams, Karen Byth, Michael J Bourke
OBJECTIVES: Perforation is the most serious complication associated with endoscopic mucosal resection (EMR). We propose a new classification for the appearance and integrity of the muscularis propria (MP) after EMR including various extents of deep mural injury (DMI). Risk factors for these injuries were analysed. DESIGN: Endoscopic images and histological specimens of consecutive patients undergoing EMR of colonic laterally spreading lesions ≥20 mm at a large Australian tertiary referral endoscopy unit were retrospectively analysed using our new DMI classification system...
July 27, 2016: Gut
Eric Y Lee, Michael J Bourke
No abstract text is available yet for this article.
August 2016: Gastrointestinal Endoscopy
Gretchen N Neigh, Christina L Nemeth, Sean D Kelly, Emily E Hardy, Chase Bourke, Zachary N Stowe, Michael J Owens
Prenatal stress has been linked to deficits in neurological function including deficient social behavior, alterations in learning and memory, impaired stress regulation, and susceptibility to adult disease. In addition, prenatal environment is known to alter cardiovascular health; however, limited information is available regarding the cerebrovascular consequences of prenatal stress exposure. Vascular disturbances late in life may lead to cerebral hypoperfusion which is linked to a variety of neurodegenerative and psychiatric diseases...
July 12, 2016: Physiology & Behavior
Farzan F Bahin, Khalid N Rasouli, Karen Byth, Luke F Hourigan, Rajvinder Singh, Gregor J Brown, Simon A Zanati, Alan Moss, Spiro Raftopoulos, Stephen J Williams, Michael J Bourke
OBJECTIVES: Clinically significant bleeding (CSPEB) is the most frequent adverse event following wide-field endoscopic mucosal resection (WF-EMR) of large sessile and laterally spreading colorectal lesions (LSL). There is limited knowledge regarding accurate prediction of CSPEB. We aimed to derive a score to predict the risk of CSPEB. METHODS: Data on patient and lesion characteristics and outcomes from WF-EMRs of LSL ≥20 mm at 8 referral hospitals were analyzed...
August 2016: American Journal of Gastroenterology
Michael E Bourke
No abstract text is available yet for this article.
February 8, 2016: Canadian Journal of Cardiology
Farzan F Bahin, Maria Pellise, Stephen J Williams, Michael J Bourke
BACKGROUND AND AIMS: Effective interventions to prevent residual and/or recurrent adenoma (RRA) after EMR of large sessile and laterally spreading colorectal lesions (LSL) are yet to be determined. RRA may occur due to inconspicuous adenoma at the EMR margin. We aimed to determine the efficacy and safety of extended EMR (X-EMR) compared with standard EMR (S-EMR). METHODS: A single-center post hoc analysis of LSL ≥20 mm referred for treatment was performed. S-EMR was the standard sequential inject and resect method including a 1-mm to 2-mm margin of normal mucosa around the lesion...
May 14, 2016: Gastrointestinal Endoscopy
Nicholas G Burgess, Lobke Desomer, Duncan McLeod, Michael J Bourke
No abstract text is available yet for this article.
May 2016: American Journal of Gastroenterology
Nicholas G Burgess, Michael J Bourke
No abstract text is available yet for this article.
May 2016: Endoscopy
Farzan F Bahin, Khalid N Rasouli, Stephen J Williams, Eric Y T Lee, Michael J Bourke
BACKGROUND AND STUDY AIMS: Clinically significant bleeding (CSPEB) is the most common adverse event following endoscopic mucosal resection (EMR) of large sessile and laterally spreading colorectal lesions (LSLs), and is associated with morbidity and resource utilization. CSPEB occurs more frequently with proximal LSLs. Prophylactic clipping of the post-EMR defect may be beneficial in CSPEB prevention. The aim of this study was to determine the cost-effectiveness of a prophylactic clipping strategy...
August 2016: Endoscopy
Patrick F Forde, Mira Sadadcharam, Michael G Bourke, Thomas A Conway, Shane R Guerin, Marcel de Kruijf, Gerald C O'Sullivan, Joseph Impellizeri, Anthony J P Clover, Declan M Soden
BACKGROUND AND STUDY AIMS: Targeted delivery of specific chemotherapeutic drugs into tumors can be achieved by delivering electrical pulses directly to the tumor tissue. This causes a transient formation of pores in the cell membrane that enables passive diffusion of normally impermeant drugs. A novel device has been developed to enable the endoscopic delivery of this tumor permeabilizing treatment. The aim of the preclinical studies described here was to investigate the efficacy and safety of this nonthermal ablation system in the treatment of gastrointestinal cancer models...
May 2016: Endoscopy
Nicholas Tutticci, Amir Klein, Rebecca Sonson, Michael J Bourke
BACKGROUND AND STUDY AIMS: Endoscopic mucosal resection (EMR) is an established treatment for large (≥ 20 mm) laterally spreading lesions (LSLs). LSLs with complete or subtotal (> 90 %) circumferential extent (C-LSLs) are generally referred for surgery. Data on technique, efficacy, and safety of EMR for these lesions are absent. The aim of this study was to describe the technique and long-term outcomes of EMR for C-LSLs. PATIENTS AND METHODS: Prospective observational study of consecutive patients referred for EMR of LSL at a tertiary care center over 63 months to April 2015...
May 2016: Endoscopy
Michael Myint, Olaf Schouten, Victor Bourke, Shannon D Thomas, Andrew F Lennox, Ramon L Varcoe
PURPOSE: To evaluate the safety and midterm patency of the Supera interwoven nitinol stent in a real-world population and determine deployment and patient-related factors that may predispose to loss of patency. METHODS: A retrospective analysis was conducted of 111 consecutive limbs from 97 patients (mean age 75.3 years; 68 men) with severe atherosclerotic disease of the superficial femoral and popliteal arteries that were treated with Supera stents between June 2012 and October 2014...
June 2016: Journal of Endovascular Therapy
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