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Michael Bourke

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https://www.readbyqxmd.com/read/28070216/metabolism-in-anoxic-permeable-sediments-is-dominated-by-eukaryotic-dark-fermentation
#1
Michael F Bourke, Philip J Marriott, Ronnie N Glud, Harald Hasler-Sheetal, Manoj Kamalanathan, John Beardall, Chris Greening, Perran L M Cook
Permeable sediments are common across continental shelves and are critical contributors to marine biogeochemical cycling. Organic matter in permeable sediments is dominated by microalgae, which as eukaryotes have different anaerobic metabolic pathways to prokaryotes such as bacteria and archaea. Here we present analyses of flow-through reactor experiments showing that dissolved inorganic carbon is produced predominantly as a result of anaerobic eukaryotic metabolic activity. In our experiments, anaerobic production of dissolved inorganic carbon was consistently accompanied by large dissolved H2 production rates, suggesting the presence of fermentation...
January 2017: Nature Geoscience
https://www.readbyqxmd.com/read/28061339/how-to-perform-high-quality-endoscopic-mucosal-resection-during-colonoscopy
#2
Amir Klein, Michael J Bourke
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/27986114/endoscopic-detection-of-large-and-advanced-colonic-lesions-are-we-missing-the-forest-for-the-trees
#3
EDITORIAL
David J Tate, Nicholas G Burgess, Michael J Bourke
No abstract text is available yet for this article.
January 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27931634/complications-of-endoscopic-polypectomy-endoscopic-mucosal-resection-and-endoscopic-submucosal-dissection-in-the-colon
#4
REVIEW
Michael X Ma, Michael J Bourke
Endoscopic resection (ER), including endoscopic polypectomy (EP), endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) are used to remove superficial neoplasms from the colon. Snare resection is used for EP and EMR, whereas endoscopic knives are used to perform dissection in the submucosal space in ESD. 80-90% colonic polyps are <10 millimetres (mm) and are effectively managed by conventional EP. Increasingly cold snare polypectomy is preferred. Large laterally spreading lesions (LSLs) and sessile polyps ≥20 mm are primarily removed by EMR...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27908600/adenoma-recurrence-after-piecemeal-colonic-emr-is-predictable-the-sydney-emr-recurrence-tool
#5
David J Tate, Lobke Desomer, Amir Klein, Gregor Brown, Luke F Hourigan, Eric Yt Lee, Alan Moss, Donald Ormonde, Spiro Raftopoulos, Rajvinder Singh, Stephen J Williams, Simon Zanati, Karen Byth, Michael J Bourke
BACKGROUND AND AIMS: Endoscopic mucosal resection (EMR) is the primary treatment of large laterally spreading colonic lesions (LSL). Residual or recurrent adenoma (RRA) is a major limitation. We aimed to identify a robust method to stratify risk of RRA. METHODS: Prospective multicenter data on consecutive LSL ≥ 20mm removed by piecemeal EMR from eight Australian tertiary centers was included (September 2008 until May 2016). A logistic regression model for endoscopically determined recurrence (EDR) was created on a randomly selected half of the cohort to yield the Sydney EMR Recurrence Tool (SERT), a 4-point score to stratify the incidence of RRA based on characteristics of the index EMR...
November 28, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27846606/emergence-and-spread-of-a-human-transmissible-multidrug-resistant-nontuberculous-mycobacterium
#6
Josephine M Bryant, Dorothy M Grogono, Daniela Rodriguez-Rincon, Isobel Everall, Karen P Brown, Pablo Moreno, Deepshikha Verma, Emily Hill, Judith Drijkoningen, Peter Gilligan, Charles R Esther, Peadar G Noone, Olivia Giddings, Scott C Bell, Rachel Thomson, Claire E Wainwright, Chris Coulter, Sushil Pandey, Michelle E Wood, Rebecca E Stockwell, Kay A Ramsay, Laura J Sherrard, Timothy J Kidd, Nassib Jabbour, Graham R Johnson, Luke D Knibbs, Lidia Morawska, Peter D Sly, Andrew Jones, Diana Bilton, Ian Laurenson, Michael Ruddy, Stephen Bourke, Ian C J W Bowler, Stephen J Chapman, Andrew Clayton, Mairi Cullen, Owen Dempsey, Miles Denton, Maya Desai, Richard J Drew, Frank Edenborough, Jason Evans, Jonathan Folb, Thomas Daniels, Helen Humphrey, Barbara Isalska, Søren Jensen-Fangel, Bodil Jönsson, Andrew M Jones, Terese L Katzenstein, Troels Lillebaek, Gordon MacGregor, Sarah Mayell, Michael Millar, Deborah Modha, Edward F Nash, Christopher O'Brien, Deirdre O'Brien, Chandra Ohri, Caroline S Pao, Daniel Peckham, Felicity Perrin, Audrey Perry, Tania Pressler, Laura Prtak, Tavs Qvist, Ali Robb, Helen Rodgers, Kirsten Schaffer, Nadia Shafi, Jakko van Ingen, Martin Walshaw, Danie Watson, Noreen West, Joanna Whitehouse, Charles S Haworth, Simon R Harris, Diane Ordway, Julian Parkhill, R Andres Floto
Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M...
November 11, 2016: Science
https://www.readbyqxmd.com/read/27809739/management-of-adverse-events-related-to-new-cancer-immunotherapy-immune-checkpoint-inhibitors
#7
Jack M Bourke, Michael O'Sullivan, Muhammad A Khattak
New immunotherapies have significantly improved survival in certain advanced cancers in recent years, particularly metastatic melanoma and lung cancer. The most effective of these therapies are the immune checkpoint inhibitors (ICIs) such as ipilimumab, nivolumab and pembrolizumab. The use of ICIs will continue to increase in the coming years as evidence of their benefit in a range of other cancers builds. ICIs are associated with novel immune-related adverse events (irAEs), which can involve a wide range of organs...
November 7, 2016: Medical Journal of Australia
https://www.readbyqxmd.com/read/27802153/expert-opinions-and-scientific-evidence-for-colonoscopy-key-performance-indicators
#8
REVIEW
Colin J Rees, Roisin Bevan, Katharina Zimmermann-Fraedrich, Matthew D Rutter, Douglas Rex, Evelien Dekker, Thierry Ponchon, Michael Bretthauer, Jaroslaw Regula, Brian Saunders, Cesare Hassan, Michael J Bourke, Thomas Rösch
Colonoscopy is a widely performed procedure with procedural volumes increasing annually throughout the world. Many procedures are now performed as part of colorectal cancer screening programmes. Colonoscopy should be of high quality and measures of this quality should be evidence based. New UK key performance indicators and quality assurance standards have been developed by a working group with consensus agreement on each standard reached. This paper reviews the scientific basis for each of the quality measures published in the UK standards...
October 8, 2016: Gut
https://www.readbyqxmd.com/read/27747280/mucosal-colonic-defect-post-emr-or-esd-to-close-or-not
#9
Nicholas G Burgess, Michael J Bourke
No abstract text is available yet for this article.
October 2016: Endoscopy International Open
https://www.readbyqxmd.com/read/27701839/breast-localization-techniques-and-margin-definitions-used-by-australian-and-new-zealand-surgeons
#10
Donna B Taylor, Anita G Bourke, Max M Hobbs, Glenys Dixon, Michael Phillips, Christobel M Saunders
No abstract text is available yet for this article.
October 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27697750/assessing-the-impact-and-cost-of-short-term-health-workforce-in-remote-indigenous-communities-in-australia-a-mixed-methods-study-protocol
#11
John Wakerman, John Humphreys, Lisa Bourke, Terry Dunbar, Michael Jones, Timothy A Carey, Steven Guthridge, Deborah Russell, David Lyle, Yuejen Zhao, Lorna Murakami-Gold
BACKGROUND: Remote Australia is a complex environment characterized by workforce shortages, isolated practice, a large resident Indigenous population, high levels of health need, and limited access to services. In recent years, there has been an increasing trend of utilizing a short-term visiting (fly-in/fly-out) health workforce in many remote areas. However, there is a dearth of evidence relating to the impact of this transitory workforce on the existing resident workforce, consumer satisfaction, and the effectiveness of current services...
October 3, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27671336/integrated-genetic-epigenetic-and-transcriptional-profiling-identifies-molecular-pathways-in-the-development-of-laterally-spreading-tumors
#12
Luke B Hesson, Benedict Ng, Peter Zarzour, Sameer Srivastava, Chau-To Kwok, Deborah Packham, Andrea C Nunez, Dominik Beck, Regina Ryan, Ashraf Dower, Caroline E Ford, John E Pimanda, Mathew A Sloane, Nicholas J Hawkins, Michael J Bourke, Jason W H Wong, Robyn L Ward
: Laterally spreading tumors (LST) are colorectal adenomas that develop into extremely large lesions with predominantly slow progression to cancer, depending on lesion subtype. Comparing and contrasting the molecular profiles of LSTs and colorectal cancers offers an opportunity to delineate key molecular alterations that drive malignant transformation in the colorectum. In a discovery cohort of 11 LSTs and paired normal mucosa, we performed a comprehensive and unbiased screen of the genome, epigenome, and transcriptome followed by bioinformatics integration of these data and validation in an additional 84 large, benign colorectal lesions...
December 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27528742/targeting-cancer-using-kat-inhibitors-to-mimic-lethal-knockouts
#13
REVIEW
James A L Brown, Emer Bourke, Leif A Eriksson, Michael J Kerin
Two opposing enzyme classes regulate fundamental elements of genome maintenance, gene regulation and metabolism, either through addition of an acetyl moiety by histone acetyltransferases (HATs) or its removal by histone de-acetyltransferases (HDAC), and are exciting targets for drug development. Importantly, dysfunctional acetylation has been implicated in numerous diseases, including cancer. Within the HAT superfamily the MYST family holds particular interest, as its members are directly involved in the DNA damage response and repair pathways and crucially, several members have been shown to be down-regulated in common cancers (such as breast and prostate)...
August 15, 2016: Biochemical Society Transactions
https://www.readbyqxmd.com/read/27464708/deep-mural-injury-and-perforation-after-colonic-endoscopic-mucosal-resection-a-new-classification-and-analysis-of-risk-factors
#14
Nicholas G Burgess, Milan S Bassan, Duncan McLeod, Stephen J Williams, Karen Byth, Michael J Bourke
OBJECTIVES: Perforation is the most serious complication associated with endoscopic mucosal resection (EMR). We propose a new classification for the appearance and integrity of the muscularis propria (MP) after EMR including various extents of deep mural injury (DMI). Risk factors for these injuries were analysed. DESIGN: Endoscopic images and histological specimens of consecutive patients undergoing EMR of colonic laterally spreading lesions ≥20 mm at a large Australian tertiary referral endoscopy unit were retrospectively analysed using our new DMI classification system...
July 27, 2016: Gut
https://www.readbyqxmd.com/read/27425801/emr-should-be-the-first-line-treatment-for-large-laterally-spreading-colorectal-lesions
#15
EDITORIAL
Eric Y Lee, Michael J Bourke
No abstract text is available yet for this article.
August 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27422674/prenatal-stress-induced-increases-in-hippocampal-von-willebrand-factor-expression-are-prevented-by-concurrent-prenatal-escitalopram
#16
Gretchen N Neigh, Christina L Nemeth, Sean D Kelly, Emily E Hardy, Chase Bourke, Zachary N Stowe, Michael J Owens
Prenatal stress has been linked to deficits in neurological function including deficient social behavior, alterations in learning and memory, impaired stress regulation, and susceptibility to adult disease. In addition, prenatal environment is known to alter cardiovascular health; however, limited information is available regarding the cerebrovascular consequences of prenatal stress exposure. Vascular disturbances late in life may lead to cerebral hypoperfusion which is linked to a variety of neurodegenerative and psychiatric diseases...
July 13, 2016: Physiology & Behavior
https://www.readbyqxmd.com/read/27296942/prediction-of-clinically-significant-bleeding-following-wide-field-endoscopic-resection-of-large-sessile-and-laterally-spreading-colorectal-lesions-a-clinical-risk-score
#17
Farzan F Bahin, Khalid N Rasouli, Karen Byth, Luke F Hourigan, Rajvinder Singh, Gregor J Brown, Simon A Zanati, Alan Moss, Spiro Raftopoulos, Stephen J Williams, Michael J Bourke
OBJECTIVES: Clinically significant bleeding (CSPEB) is the most frequent adverse event following wide-field endoscopic mucosal resection (WF-EMR) of large sessile and laterally spreading colorectal lesions (LSL). There is limited knowledge regarding accurate prediction of CSPEB. We aimed to derive a score to predict the risk of CSPEB. METHODS: Data on patient and lesion characteristics and outcomes from WF-EMRs of LSL ≥20 mm at 8 referral hospitals were analyzed...
August 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27267091/coronary-care-unit-to-cardiac-intensive-care-unit-acute-medical-cardiac-care-adapting-with-the-times
#18
Michael E Bourke
No abstract text is available yet for this article.
February 8, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/27189660/extended-endoscopic-mucosal-resection-does-not-reduce-recurrence-compared-with-standard-endoscopic-mucosal-resection%C3%A2-of-large-laterally-spreading%C3%A2-colorectal-lesions
#19
Farzan F Bahin, Maria Pellise, Stephen J Williams, Michael J Bourke
BACKGROUND AND AIMS: Effective interventions to prevent residual and/or recurrent adenoma (RRA) after EMR of large sessile and laterally spreading colorectal lesions (LSL) are yet to be determined. RRA may occur due to inconspicuous adenoma at the EMR margin. We aimed to determine the efficacy and safety of extended EMR (X-EMR) compared with standard EMR (S-EMR). METHODS: A single-center post hoc analysis of LSL ≥20 mm referred for treatment was performed. S-EMR was the standard sequential inject and resect method including a 1-mm to 2-mm margin of normal mucosa around the lesion...
May 14, 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/27151124/traditional-serrated-adenomas-not-all-serrations-are-the-same
#20
Nicholas G Burgess, Lobke Desomer, Duncan McLeod, Michael J Bourke
No abstract text is available yet for this article.
May 2016: American Journal of Gastroenterology
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