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https://www.readbyqxmd.com/read/28143427/nomogram-prediction-of-individual-prognosis-of-patients-with-hepatocellular-carcinoma
#1
Gang Wan, Fangyuan Gao, Jialiang Chen, Yuxin Li, Mingfan Geng, Le Sun, Yao Liu, Huimin Liu, Xue Yang, Rui Wang, Ying Feng, Xianbo Wang
BACKGROUND: The purpose of this study was to develop an effective nomogram capable of estimating the individual survival outcomes of patients with hepatocellular carcinoma (HCC), and compare the predictive accuracy and discriminative ability with other staging systems. METHODS: The nomogram was established based on a retrospective study of 661 patients newly diagnosed with HCC at the Beijing Ditan Hospital (Beijing, China), Capital Medical University, between October 2008 and July 2012...
January 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/27990837/unusual-presentation-of-infection-by-helicobacter-pylori-gastritis-associated-with-russell-bodies-infrequent-and-poorly-understood-pathology
#2
Viviana Parra Vargas, Diego M Aponte, Eligio Antonio Álvarez
Russell bodies gastritis is a very rare disease, with few cases reported in literature, and characterized by the finding of plasma cells with eosinophilic intracytoplasmic inclusions in the gastric mucosa, called Mott cells. Although it has been partnered since its first description to Helicobacter pylori infection, it is important to considered differential diagnoses such as lymphoplasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT) lymphoma, plasmacytoma and signet ring cell carcinom. In this case report, we address a patient with histologic confirmation and her follow up...
January 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/27968849/a-novel-risk-score-mcct-to-guide-decision-for-treatment-of-advanced-hepatocellular-carcinoma-with-transarterial-chemoembolisation-a-derivation-and-validation-study
#3
Yong-Fa Zhang, Ming Shi, Rong-Ping Guo
BACKGROUND: Transarterial chemoembolisation (TACE) is still widely used to treat patients with advanced hepatocellular carcinoma who have no access to sorafenib in Asia. However, the indication of TACE for these patients has yet to be established. We established an objective point score to guide this decision in patients with advanced-stage hepatocellular carcinoma. METHODS: We developed a scoring system (MCCT score) based on preoperative data from a cohort of 422 patients receiving TACE as the first treatment for advanced hepatocellular carcinoma from 2006 to 2013 at Sun Yat-sen University Cancer Center, Guangzhou, China...
October 2016: Lancet
https://www.readbyqxmd.com/read/27825410/conventional-tumor-markers-in-cerebralspinal-fluid-in-patients-with-elevated-serum-br-tumor-markers-and-without-central-nervous-system-malignant-diseases
#4
Zhi-Jie Liu, Qiang Shi, Bin Lu, Zhen Zhang, Cheng-Lin Tian
Objective To explore the diffusion pattern of tumor markers (TM) from serum to cerebrospinal fluid (CSF) via the blood-brain barrier in patients with elevated serum tumor markers (TM).Methods Inpatients receiving lumbar puncture during hospitalization in our center from January 1, 2013 to December 31, 2015 were divided into study group (n=181) and control group (n=251). The study group consisted of patients with elevated serum TMs but without malignant central nervous system diseases. The control group consisted of patients with normal serum TM levels and without malignant diseases...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27713152/detection-of-cellular-senescence-within-human-invasive-breast-carcinomas-distinguishes-different-breast-tumor-subtypes
#5
Cristina L Cotarelo, Arno Schad, Charles James Kirkpatrick, Jonathan P Sleeman, Erik Springer, Marcus Schmidt, Sonja Thaler
Oncogene-induced senescence is thought to act as a barrier to tumorigenesis by arresting cells at risk of malignant transformation. Nevertheless, numerous findings suggest that senescent cells may conversely promote tumor progression through the development of the senescence-associated secretome they produce. It is likely that the composition and the physiological consequences mediated by the senescence secretome are dependent on the oncogenes that trigger the senescence program. Breast cancer represents a heterogenous disease that can be divided into breast cancer subtypes due to different subsets of genetic and epigenetic abnormalities...
October 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27568484/synthesis-molecular-modeling-and-biological-evaluation-of-4-alkoxyquinazoline-derivatives-as-novel-inhibitors-of-vegfr2
#6
Liang Lu, Ting-Ting Zhao, Tian-Bao Liu, Wen-Xue Sun, Chen Xu, Dong-Dong Li, Hai-Liang Zhu
A series of novel quinazoline derivatives have been designed and synthesized, and their inhibitory activities have also been tested against A549 (carcinomic human alveolar basal epithelial cell), MCF-7 (breast cancer) and HeLa (cervical cancer cell). Of these compounds, compound 4t showed the most potent inhibitory activity (IC50=0.22 µg/mL for HeLa, IC50=0.15 µg/mL for A549 and IC50=0.24 µg/mL for MCF-7). Docking simulation had been performed to position compound 4t into the vascular endothelial growth factor receptor (VEGFR) active site to determine the probable binding model...
November 1, 2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/26998418/role-of-natural-radiosensitizers-and-cancer-cell-radioresistance-an-update
#7
REVIEW
Arif Malik, Misbah Sultana, Aamer Qazi, Mahmood Husain Qazi, Gulshan Parveen, Sulayman Waquar, Abdul Basit Ashraf, Mahmood Rasool
Cancer originates from genetic mutations accumulation. Cancer stem cells have been depicted as tumorigenic cells that can differentiate and self-renew. Cancer stem cells are thought to be resistant to conventional therapy like chemotherapy and radiation therapy. Radiation therapy and chemotherapy damage carcinomic DNA cells. Because of the ability of cancer stem cells to self-renew and reproduce malignant tumors, they are the subject of intensive research. In this review, CSCs radioresistant mechanisms which include DNA damage response and natural radiosensitizers have been summed up...
2016: Analytical Cellular Pathology (Amsterdam)
https://www.readbyqxmd.com/read/26899006/-expression-and-clinical-significance-of-dyrk1b-in-the-specimens-and-cells-of-cervical-lesions
#8
Jiao Lin, Pengxin Zhang, Lu Pang, Jingying Chen, Wen Sun, Wenjing Qi, Yunyi Lyu, Hongwei Guan, Jingchun Gao
OBJECTIVE: To detect and explore the expression and clinical significance of dual specificity tyrosine phosphorylation regulated kinase1b (Dyrk1b) in the specimens and cells of cervical lesions. METHODS: (1) All the data were collected from 75 patients with cervical cancer and 52 cases with squamous intraepithelial lesion (SIL) admitted in the First Affiliated Hospital of Dalian Medical College during Jan. 2011 to Dec. 2013 and confirmed by pathological examination, included 60 cases of stage Ⅰ and 15 cases of stage Ⅱ, 12 cases with low-grade squamous intraepithelial lesion (LSIL) and 40 cases with high-grade squamous intraepithelial lesion (HSIL)...
January 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/26877519/p-209-severe-hyponatremia-revealing-a-small-cell-carcinoma
#9
K Batouche, I Mancini, B Filleul, D D Batouche
OBJECTIFS: Le but de ce bref rapport est de fournir des informations spécifiques pour la gestion de syndrome de sécrétion inappropriée d'hormone antidiurétique (SIADH) dans la pratique clinique en oncologie. MéTHODES: Nous rapportons un cas d'hyponatrémie sévère ayant entraîné une prise en charge en soins intensifs et en oncologie. RéSULTATS: Mme DJ 60 ans, aux antécédents d'HTA et tabagisme chronique, admise en janvier 2013 aux urgences de cardiologie pour une poussée d'HTA...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26395957/-signet-ring-cell-colorectal-carcinom-case-report
#10
Z Matkovčík, J Hlad
Signet ring cell colorectal carcinoma is a rare aggressive tumor. The incidence of this desease is very low in young patients and accounts up to 1% of all surgical patients with colorectal cancer. The infrequency of the disease among young patients makes the diagnosis more difficult and the prognosis less favourable. Biopsy results are crucial for verification of signet ring cell carcinoma. Treatment is similar as in other types of colorectal cancer. We report a case of signet ring cell colon cancer in a 22 years old female patient...
August 2015: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/25725438/prognostic-nomogram-for-patients-with-unresectable-hepatocellular-carcinoma-after-transcatheter-arterial-chemoembolization
#11
Li Xu, Zhen-Wei Peng, Min-Shan Chen, Ming Shi, Yao-Jun Zhang, Rong-Ping Guo, Xiao-Jun Lin, Wan-Yee Lau
BACKGROUND & AIMS: To establish an effective prognostic nomogram for patients with unresectable hepatocellular carcinoma (HCC) after transarterial chemoembolization (TACE). METHODS: The nomogram was constructed based on data obtained from a retrospective study on 2938 patients who received TACE as an initial therapy from 2000 to 2008. The predictive accuracy and discriminative ability of the nomogram were compared with seven current commonly used staging systems on HCC by using data obtained from a prospective study on a cohort of 647 patients treated from January 2011 to December 2011 at the same institution...
July 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25715593/-anti-tumour-activity-of-dinitrosyl-iron-complexes-with-glutathione
#12
A F Vanin, L A Ostrovskaia, D B Korman, R R Borodulin, L N Kubrina, M M Fomina, N V Bliukhterova, V A Rykova
The anti-tumour dose-dependent effect of binuclear dinitrosyl iron complexes with glutathione as NO donors on solid tumour in the mouse Lewis lung carcinome was detected. The complexes being injected at the doses of 21, 42, 105 mg/kg daily during 10 days blocked completely the development of the tumour for the first week after tumour cell implantation into animals. After that, the part of tumour cells which remained in intact alive state began to grow at the rate equal to that for control animals. The effect was proposed to be caused via the formation of the anti-nitrosative defense system in the cells as a response to NO attack to cells...
May 2014: Biofizika
https://www.readbyqxmd.com/read/25473368/the-protective-role-of-ellagitannins-flavonoids-pretreatment-against-n-nitrosodiethylamine-induced-hepatocellular-carcinoma
#13
Rasha H Hussein, Fares K Khalifa
Ellagitannins are esters of glucose with hexahydroxydiphenic acid; when hydrolyzed, they yield ellagic acid (EA), the dilactone of hexahydroxydiphenic acid. EA has been receiving the most attention, because it has potent antioxidant activity, radical scavenging capacity, chemopreventive and antiapoptotic properties. Hepatocellular carcinoma (HCC) is the most frequent primary malignancy of liver, and accounts for as many as one million deaths worldwide in a year. The aim of the present study was to evaluate the antioxidant and chemopreventive efficiency of ellagic acid against N-nitrosodiethylamine (NDEA) induced hepatocarcinogenesis in rats...
December 2014: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/25284616/causes-and-consequences-of-portal-vein-thrombosis-in-1-243-patients-with-cirrhosis-results-of-a-longitudinal-study
#14
RANDOMIZED CONTROLLED TRIAL
Filipe Nery, Sylvie Chevret, Bertrand Condat, Emmanuelle de Raucourt, Larbi Boudaoud, Pierre-Emmanuel Rautou, Aurelie Plessier, Dominique Roulot, Cendrine Chaffaut, Valerie Bourcier, Jean-Claude Trinchet, Dominique-Charles Valla
UNLABELLED: In cirrhosis, portal vein thrombosis (PVT) could be a cause or a consequence of the progression of liver disease. We analyzed data from a prospective trial of ultrasound screening for hepatocellular carcinoma in order to identify risk factors for and the impact of PVT in patients with cirrhosis. In all, 1,243 adults with cirrhosis without PVT were enrolled from 43 liver units in France and Belgium between June 2000 and March 2006. The mean follow-up was 47 months. Doppler ultrasonography was used to check the portal vein...
February 2015: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/24941680/-postoperative-radiation-therapy-in-lung-carcinom
#15
REVIEW
H Bouchaab, S Peters, M Ozsahin, N Peguret, M Gonzales, A Lovis
Locally advanced non-small-cell lung carcinoma (NSCLC) is a very heterogeous disease, the role of postoperative radiation therapy (PORT) in pN2 patients with completly resected NSCLC remains controversial. Although an improvment in local control has been described in several studies, the effect on survival has been contradictory or inconclusive. Retrospective evaluation suggest a positive effect of PORT in high risk patients with pN2 disease: RI-resected NSCLC, bulky and multilevel N2. However further evaluation of PORT in prospectively randomized studies in completely resected pN2 NSCLC is needed...
May 21, 2014: Revue Médicale Suisse
https://www.readbyqxmd.com/read/24793716/cell-uptake-and-oral-absorption-of-titanium-dioxide-nanoparticles
#16
G Janer, E Mas del Molino, E Fernández-Rosas, A Fernández, S Vázquez-Campos
Large efforts are invested on the development of in vitro tests to evaluate nanomaterial (NM) toxicity. In order to assess the relevance of the adverse effects identified in in vitro toxicity tests a thorough understanding of the biokinetics of NMs is critical. We used different in vitro and in vivo test methods to evaluate cell uptake and oral absorption of titanium dioxide nanoparticles (TiO2 NPs). These NPs were readily uptaken by A549 cells (carcinomic human alveolar basal epithelial cells) in vitro. Such rapid uptake contrasted with a very low oral absorption in a differentiated Caco-2 monolayer system (human epithelial colorectal adenocarcinoma cells) and after oral gavage administration to rats...
July 15, 2014: Toxicology Letters
https://www.readbyqxmd.com/read/24613269/comparative-study-of-staging-systems-for-hepatocellular-carcinoma-in-428-patients-treated-with-radioembolization
#17
COMPARATIVE STUDY
Khairuddin Memon, Laura M Kulik, Robert J Lewandowski, Edward Wang, Jonathan Wang, Robert K Ryu, Ryan Hickey, Michael Vouche, Talia Baker, Daniel Ganger, Vanessa L Gates, Ali Habib, Mary F Mulcahy, Riad Salem
PURPOSE: To compare the utility of different staging systems and analyze independent predictors of survival in patients with hepatocellular carcinoma (HCC) treated with yttrium-90 ((90)Y) radioembolization. MATERIALS AND METHODS: During the period 2004-2011, 428 patients with HCC were treated with (90)Y radioembolization. All patients were staged prospectively by the following staging systems: Child-Turcotte-Pugh (CTP), United Network for Organ Sharing, Barcelona Clinic Liver Cancer (BCLC), Okuda classification, Cancer of the Liver Italian Program (CLIP), Groupe d'Etude et de Traitement du Carcinome Hepatocellulaire, Chinese University Prognostic Index, and Japan Integrated Staging...
July 2014: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/24607276/selective-anticancer-effects-of-a-synthetic-flavagline-on-human-oct4-expressing-cancer-stem-like-cells-via-a-p38-mapk-dependent-caspase-3-dependent-pathway
#18
Fathi Emhemmed, Sarah Ali Azouaou, Frédéric Thuaud, Valérie Schini-Kerth, Laurent Désaubry, Christian D Muller, Guy Fuhrmann
Cancer stem cells (CSCs) are considered as the initiators of the carcinogenic process and are therefore emerging targets for innovative anticancer therapies. In order to evaluate the anticancer chemopreventive activity of flavagline derivatives, we used the pluripotent teratocarcinomal cell as a model of Oct4-expressing cancer stem-like cell and determined the underlying cellular and molecular mechanisms induced by a synthetic flavagline. We precisely investigated the effects of the flavagline derivative FL3 on the human embryonal carcinoma (EC) cell line NT2/D1 and compared the responses to those of a normal more restrictive pluripotent stem cell line (i...
May 15, 2014: Biochemical Pharmacology
https://www.readbyqxmd.com/read/24250076/immunohistochemical-expression-of-basement-membrane-laminin-in-histological-grades-of-oral-squamous-cell-carcinoma-a-semiquantitative-analysis
#19
R Shruthy, P Sharada, Uma Swaminathan, Br Nagamalini
BACKGROUND AND OBJECTIVES: To determine the immunohistochemical (IHC) localization of basement membrane component laminin in histological grades of oral squamous cell carcinoma (OSCC). The purpose of this study was to demonstrate the loss of continuity of the basement membrane in OSCC using an antibody directed against laminin using advanced polymer staining system. MATERIALS AND METHODS: A total of 30 cases of OSCC: 10 cases of well differentiated squamous cell carcinom (WDSCC), 10 cases of moderately differentiated squamous cell carcinoma (MDSCC), and 10 cases of poorly differentiated squamous cell carcinoma (PDSCC) were subjected to heat-induced antigen retrieval method using ethylene-di-amine-tetraacetic acid buffer in a microwave oven...
May 2013: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/24167997/-expression-of-il-17-in-laryngeal-squamous-cell-carcinoma-tissues-and-the-clinical-significance
#20
Yatang Wang, Jianming Yang, Haiyan Xu
OBJECTIVE: To investigate the expression of interleukin 17 in laryngeal squamous cell carcinoma tissues, and to evaluate the value of interleukin-17 in the biological behavior and prognosis of laryngeal squamous cell carcinom. METHOD: Expressions of IL-17 were analyzed in 71 laryngeal squamous cell carcinoma samples and 21 cases of adjacent tissues of carcinoma as control by immunohistochemistry. RESULT: The expression of IL-17 in laryngeal squamous cell carcinoma tissues was obviously higher than that in adjacent tissues (P < 0...
July 2013: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
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