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chemotherapy and cardiotoxicity

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https://www.readbyqxmd.com/read/29458045/aldose-reductase-inhibitor-fidarestat-prevents-doxorubicin-induced-endothelial-cell-death-and-dysfunction
#1
Himangshu Sonowal, Pabitra Pal, Kirtikar Shukla, Ashish Saxena, Satish K Srivastava, Kota V Ramana
Despite doxorubicin (Dox) being one of the most widely used chemotherapy agents for breast, blood and lung cancers, its use in colon cancer is limited due to increased drug resistance and severe cardiotoxic side effects that increase mortality associated with its use at high doses. Therefore, better adjuvant therapies are warranted to improve the chemotherapeutic efficacy and to decrease cardiotoxicity. We have recently shown that aldose reductase inhibitor, fidarestat, increases the Dox-induced colon cancer cell death and reduces cardiomyopathy...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29450683/common-adverse-effects-of-novel-therapies-for-multiple-myeloma-mm-and-their-management-strategies
#2
REVIEW
Kristen B McCullough, Miriam A Hobbs, Jithma P Abeykoon, Prashant Kapoor
PURPOSE OF REVIEW: The purpose of this review was to evaluate management strategies for common adverse effects of novel therapies in multiple myeloma (MM), including immunomodulatory drugs, proteasome inhibitors, monoclonal antibodies, and a histone deacetylase inhibitor. RECENT FINDINGS: There are several adverse effects that occur across multiple classes of antimyeloma drugs, including rash, peripheral neuropathy, infusion reactions, and cardiotoxicity, but most can be managed without complete discontinuation of the agent or abandonment of the class...
February 15, 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29440899/aptamer-drug-conjugate-targeted-delivery-of-doxorubicin-in-a-her3-aptamer-functionalized-liposomal-delivery-system-reduces-cardiotoxicity
#3
Xiao-Qian Dou, Hua Wang, Jing Zhang, Fang Wang, Gui-Li Xu, Cheng-Cheng Xu, Huan-Hua Xu, Shen-Si Xiang, Jie Fu, Hai-Feng Song
Introduction: The toxic side effects of doxorubicin (DOX) have limited its use in chemotherapy. Neither liposomal DOX nor pegylated liposomal DOX are able to completely resolve this issue. This is a proof-of-concept study testing aptamer-drug conjugate (ApDC) targeted delivery systems for chemotherapeutic drugs. Methods: Aptamer library targeting human epidermal growth factor receptor 3 (HER3) was screened and affinity was determined by enzyme-linked immunosorbent assay...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29434549/protective-mechanism-of-hydrogen-sulfide-against-chemotherapy-induced-cardiotoxicity
#4
REVIEW
Shuxu Du, Yaqian Huang, Hongfang Jin, Tianyou Wang
Over the past few decades, the number of long term survivors of childhood cancers has been increased exponentially. However, among these survivors, treatment-related toxicity, especially cardiotoxicity, is becoming the essential cause of morbidity and mortality. Thus, preventing the treatment-related adverse effects is important to increase the event free survival during the treatment of cancer in children and adolescents. Accumulating evidence has demonstrated that hydrogen sulfide (H2S) exerts a protective role on cardiomyocytes through a variety of mechanisms...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29413646/assessment-of-left-ventricular-function-by-echocardiography-the-case-for-routinely-adding-global-longitudinal-strain-to-ejection-fraction
#5
REVIEW
Elizabeth Potter, Thomas H Marwick
Left ventricular (LV) ejection fraction (LVEF) is a simple measure of global systolic function that pervades the risk evaluation and management of many cardiovascular diseases. However, this parameter is limited not only by technical challenges, but also by pathophysiological entities where the ratio of stroke volume to LV cavity size is preserved. The assessment of global longitudinal strain (GLS) from speckle-tracking analysis of 2-dimensional echocardiography has become a clinically feasible alternative to LVEF for the measurement of myocardial function...
February 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29413379/left-ventricular-dysfunction-in-cancer%C3%A2-treatment-is-it-relevant
#6
REVIEW
Benjamin Kenigsberg, Anton Wellstein, Ana Barac
Contemporary cancer therapies have dramatically improved cancer-free and overall survival but have been accompanied by increasing cancer treatment-related cardiovascular toxicity, including left ventricular (LV) systolic dysfunction. Previously, systemic chemotherapy with anthracyclines and radiation therapy were the only cancer treatments with significant cardiotoxicity. However, modern targeted cancer therapies, including HER2 inhibitors, tyrosine kinase inhibitors (TKIs), proteasome inhibitors, and immune checkpoint inhibitors, have all been associated with adverse cardiovascular events...
February 2018: JACC. Heart Failure
https://www.readbyqxmd.com/read/29402309/embryonic-stem-cell-derived-cardiomyocytes-for-the-treatment-of-doxorubicin-induced-cardiomyopathy
#7
Danúbia Silva Dos Santos, Guilherme Visconde Brasil, Isalira Peroba Rezende Ramos, Fernanda Cristina Paccola Mesquita, Tais Hanae Kasai-Brunswick, Michelle Lopes Araújo Christie, Gustavo Monnerat Cahli, Raiana Andrade Quintanilha Barbosa, Sandro Torrentes da Cunha, Jonathas Xavier Pereira, Emiliano Medei, Antonio Carlos Campos de Carvalho, Adriana Bastos Carvalho, Regina Coeli Dos Santos Goldenberg
BACKGROUND: Doxorubicin (Dox) is a chemotherapy drug with limited application due to cardiotoxicity that may progress to heart failure. This study aims to evaluate the role of cardiomyocytes derived from mouse embryonic stem cells (CM-mESCs) in the treatment of Dox-induced cardiomyopathy (DIC) in mice. METHODS: The mouse embryonic stem cell (mESC) line E14TG2A was characterized by karyotype analysis, gene expression using RT-PCR and immunofluorescence. Cells were transduced with luciferase 2 and submitted to cardiac differentiation...
February 5, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29392625/detection-of-chemotherapy-induced-cardiotoxicity-with-antimyosin-pretargeted-imaging
#8
EDITORIAL
H William Strauss, Giuliano Mariani
No abstract text is available yet for this article.
February 1, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29392452/ysa-conjugated-mesoporous-silica-nanoparticles-effectively-target-epha2-overexpressing-breast-cancer-cells
#9
Zhi Liu, Zijian Tao, Qing Zhang, Song Wan, Fenglin Zhang, Yan Zhang, Guanyu Wu, Jiandong Wang
PURPOSE: Neoadjuvant chemotherapy is commonly used to treat patients with locally advanced breast cancer and a common option for primary operable disease. However, systemic toxicity including cardiotoxicity and inefficient delivery are significant challenges form any chemotherapeutics. The development of targeted treatments that lower the risk of toxicity has, therefore, become an active area of research in the field of novel cancer therapeutics. Mesoporous silica nanoparticles (MSNs) have attracted significant attention as efficient drug delivery carriers, due to their high surface area and tailorable mesoporous structures...
February 1, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29381962/effects-of-treatment-with-chemotherapy-and-or-tamoxifen-on-the-biomarkers-of-cardiac-injury-and-oxidative-stress-in-women-with-breast-cancer
#10
Fabricio Bragança Silva, Walckiria Garcia Romero, Ana Ligia Rodrigues de Abreu Carvalho, Gleyce Ariadne Alves Souza, Erick Roberto Gonçalves Claudio, Glaucia Rodrigues Abreu
There has been an increase in deaths from cardiovascular diseases following breast cancer therapy. Evidence has shown that this outcome is, in part, associated with cardiotoxicity induced by the chemotherapeutic drugs and the increase in oxidative stress. The aim of this study was to evaluate the effects of chemotherapy and hormone therapy with tamoxifen on the biomarkers of cardiac injury and oxidative stress in women with breast cancer.Thirty women were followed-up for 1 year and were divided into 3 groups according to the treatment protocol: women treated only with tamoxifen and clinical follow up for 12 months (Tam, n = 10); women treated only with chemotherapy for 6 months with clinical follow up for an additional 6-month period (Chemo, n = 10); and women who received chemotherapy for 6 months followed by a 6-month period only with tamoxifen therapy and clinical follow up (Chemo + Tam, n = 10)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29377985/cancer-therapy-induced-cardiomyopathy-can-human-induced-pluripotent-stem-cell-modelling-help-prevent-it
#11
Jonathan P Stack, Javid Moslehi, Nazish Sayed, Joseph C Wu
Cardiotoxic effects from cancer therapy are a major cause of morbidity during cancer treatment. Unexpected toxicity can occur during treatment and/or after completion of therapy, into the time of cancer survivorship. While older drugs such as anthracyclines have well-known cardiotoxic effects, newer drugs such as tyrosine kinase inhibitors, proteasome inhibitors, and immunotherapies also can cause diverse cardiovascular and metabolic complications. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly being used as instruments for disease modelling, drug discovery, and mechanistic toxicity studies...
January 25, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29374719/phase-ii-study-of-s-1-plus-trastuzumab-for-her2-positive-metastatic-breast-cancer-gbccsg-01
#12
Takaaki Fujii, Jun Horiguchi, Yasuhiro Yanagita, Yukio Koibuchi, Fumihiro Ikeda, Nobuyuki Uchida, Morihiko Kimura
AIM: Treatment strategies for patients with human epidermal growth factor 2 (HER2)-positive metastatic breast cancer (MBC) have significantly progressed. The use of trastuzumab, a monoclonal antibody targeting the HER2 (human epidermal growth factor 2) protein, in combination with chemotherapy improves survival in patients with HER2-positive breast cancer. S-1, an oral combination of fluorouracil derivatives, is widely used in Japan and is more convenient than intravenous drugs. However, little is known about the combination of S-1 and trastuzumab in patients with HER2-positive MBC...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29361617/-cardiotoxicity-of-cancer-chemotherapy-mechanisms-and-therapeutic-approach
#13
Hiroshi Akazawa
Recent progress in cancer chemotherapy has improved the long-term outcome for cancer patients. Under such circumstances, it is increasingly of clinical importance to manage the cardiovascular complications, which are related to both cancer itself and adverse effects of cancer therapies. Among the most concerning as cardiovascular complications of cancer therapies is chemotherapy-induced cardiotoxicity or chemotherapy-related cardiac dysfunction(CTRCD). CTRCD has been intuitively classified according to the extent of structural abnormalities and degree of reversibility; type 1 is irreversible and dose-dependent with structural abnormalities, and type 2 is reversible after cessation of treatment and dose-independent without structural abnormalities...
December 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29339701/subclinical-reduction-in-left-ventricular-function-using-triplane-and-2d-speckle-tracking-echocardiography-after-anthracycline-exposure-in-children
#14
Erman Çilsal, Ayşe Deniz Oğuz, Fatma Sedef Tunaoğlu, Serdar Kula, Ayhan Pektaş
OBJECTIVE: Speckle tracking echocardiography (STE) enables global and regional evaluation of the left ventricle (LV); therefore, it is the most useful method for detecting subclinical dysfunction in patients exposed to cardiotoxic agents. A novel technique triplane (3P) echocardiography also allows single beat assessment of LV global longitudinal strain values. We firstly aimed to demonstrate both two-dimensional (2D)- and 3PSTE-derived LV global longitudinal strain measurements in children after anthracycline exposure...
January 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29329420/pyrrolidine-dithiocarbamate-reverses-bcl-xl-mediated-apoptotic-resistance-to-doxorubicin-by-inducing-paraptosis
#15
Seok Soon Park, Dong Min Lee, Jun Hee Lim, Dongjoo Lee, Sang Jun Park, Hwan Myung Kim, Seonghyang Sohn, Gyesoon Yoon, Young Woo Eom, Seong-Yun Jeong, Eun Kyung Choi, Kyeong Sook Choi
Elevated Bcl-xL expression in cancer cells contributes to DOX resistance, leading to failure in chemotherapy. In addition, the clinical use of high-dose doxorubicin (DOX) in cancer therapy has been limited by issues with cardiotoxicity and hepatotoxicity. Here, we show that co-treatment with pyrrolidine dithiocarbamate (PDTC) attenuates DOX-induced apoptosis in Chang-L liver cells and human hepatocytes, but overcomes DOX resistance in Bcl-xL-overexpressing Chang-L cells and several hepatocellular carcinoma (HCC) cell lines with high Bcl-xL expression...
January 10, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29321375/highly-potent-visnagin-derivatives-inhibit-cyp1-and-prevent-doxorubicin-cardiotoxicity
#16
Aarti Asnani, Bahoui Zheng, Yan Liu, You Wang, Howard H Chen, Anita Vohra, An Chi, Ivan Cornella-Taracido, Huijun Wang, Douglas G Johns, David E Sosnovik, Randall T Peterson
Anthracyclines such as doxorubicin are highly effective chemotherapy agents used to treat many common malignancies. However, their use is limited by cardiotoxicity. We previously identified visnagin as protecting against doxorubicin toxicity in cardiac but not tumor cells. In this study, we sought to develop more potent visnagin analogs in order to use these analogs as tools to clarify the mechanisms of visnagin-mediated cardioprotection. Structure-activity relationship studies were performed in a zebrafish model of doxorubicin cardiomyopathy...
January 11, 2018: JCI Insight
https://www.readbyqxmd.com/read/29316094/integrated-multifunctional-micelles-co-self-assembled-from-polypeptides-conjugated-with-natural-ferulic-acid-and-lipoic-acid-for-efficient-and-bioresponsive-doxorubicin-delivery
#17
Zhiyuan Zhong, Tao Chen, Min Qiu, Jian Zhang, Huanli Sun, Chao Deng
How to develop safe, easily accessible, and multifunctional nanocarriers is a big theme for nanomedicine research. Here, integrated multifunctional micelles (IMM) were developed by co-self-assembly of poly(ethylene glycol)-b-poly(L-lysine) derivatives with natural ferulic acid or lipoic acid. FA confers IMM with intrinsic antitumor activity, improved loading of doxorubicin (DOX) via π-π stacking, and reduced DOX cardiotoxicity. LA provides IMM with reversible crosslinking property which leads to a high colloidal stability with inhibited drug leakage and triggered intracellular DOX release...
January 9, 2018: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/29315967/curcumin-ameliorates-doxorubicin-induced-cardiotoxicity-by-abrogation-of-inflammation-apoptosis-oxidative-dna-damage-and-protein-oxidation-in-rats
#18
Fulya Benzer, Fatih Mehmet Kandemir, Mustafa Ozkaraca, Sefa Kucukler, Cuneyt Caglayan
Doxorubicin (DXR) is a highly effective drug for chemotherapy. However, cardiotoxicity reduces its clinical utility in humans. The present study aimed to assess the ameliorative effect of curcumin against DXR-induced cardiotoxicity in rats. Rats were subjected to oral treatment of curcumin (100 and 200 mg/kg body weight) for 7 days. Cardiotoxicity was induced by single intraperitoneal injection of DXR (40 mg/kg body weight) on the 5th day and the rats sacrificed on 8th day. Curcumin ameliorated DXR-induced lipid peroxidation, glutathione depletion, decrease in antioxidant (superoxide dismutase, catalase, and glutathione peroxidase) enzyme activities, and cardiac toxicity markers (CK-MB, LDH, and cTn-I)...
January 5, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29286579/systematic-review-of-pharmacogenomics-and-adverse-drug-reactions-in-paediatric-oncology-patients
#19
REVIEW
Rachel Conyers, Subalatha Devaraja, David Elliott
Many paediatric patients with cancer experience significant chemotherapy side effects. Predisposition to drug reactions is governed by single nucleotide polymorphisms (SNPs). We performed a systematic review of the literature from 2006 through 2016. Outcomes of interest included patient characteristics, cancer type drug of interest, genes investigated, toxicity identified and genetic polymorphisms implicated. The primary toxicities studied were neurotoxicity cardiotoxicity, osteonecrosis, and thromboembolism and hypersensitivity reactions...
December 29, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29284775/l-arginine-is-an-effective-medication-for-prevention-of-endothelial-dysfunction-a-predictor-of-anthracycline-cardiotoxicity-in-patients-with-acute-leukemia
#20
I Skrypnyk, G Maslova, T Lymanets, I Gusachenko
AIM: To evaluate the effectiveness of L-arginine in the prevention of endothelial dysfunction, which may be a predictor of anthracycline-induced myocardial injury, in patients with acute leukemia (AL) on the background of anthracycline antibiotics low cumulative doses from 100 to 200 mg/m2. MATERIALS AND METHODS: A total of 81 adult AL patients (38 males and 43 females with the age of 16-59 years) were studied. The patients were divided into two groups: group I (n = 34), AL patients treated with chemotherapy (CT) and L-arginine hydrochloride; group II (n = 47) - AL patients treated with CT only...
December 2017: Experimental Oncology
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