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https://www.readbyqxmd.com/read/29793140/effectiveness-of-a-voluntary-family-befriending-service-a-mixed-methods-evaluation-using-the-donabedian-model
#1
S V Gentry, E F J Powers, N Azim, M Maidrag
OBJECTIVES: Voluntary befriending schemes operate in many countries, promoting public health by supporting vulnerable individuals and families. Use of third sector and voluntary services to complement health and social care provision is increasingly important globally in the context of economic and demographic challenges, but the evidence base around such collaborations is limited. This article reports the results of operational evaluation research seeking to use robust routine work to generate transferable findings for use by those commissioning and providing services...
May 21, 2018: Public Health
https://www.readbyqxmd.com/read/29792765/exploring-the-relationship-between-volunteering-and-hospice-sustainability-in-the-uk-a-theoretical-model
#2
Ros Scott, Divya Jindal-Snape, Gaye Manwaring
AIM: To explore the relationship between volunteering and the sustainability of UK voluntary hospices. METHODS: A narrative literature review was conducted to inform the development of a theoretical model. Eight databases were searched: CINAHL (EBSCO), British Nursing Index, Intute: Health and Life Sciences, ERIC, SCOPUS, ASSIA (CSA), Cochrane Library and Google Scholar. RESULTS: A total of 90 documents were analysed. Emerging themes included the importance of volunteering to the hospice economy and workforce, the quality of services, and public and community support...
May 2, 2018: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/29792213/rate-of-presence-of-11-thoracic-vertebrae-and-6-lumbar-vertebrae-in-asymptomatic-chinese-adult-volunteers
#3
Ying-Zhao Yan, Qing-Ping Li, Cong-Cong Wu, Xiang-Xiang Pan, Zhen-Xuan Shao, Shao-Qing Chen, Ke Wang, Xi-Bang Chen, Xiang-Yang Wang
BACKGROUND: An increasing number of studies on spinal morphology in asymptomatic Asian and Western patients have been reported. Variation in spinal anatomy among patients is considered as the cause of wrong-level surgery in up to 40% of cases. The present study examined the rate of presence of 11 thoracic vertebrae and 6 lumbar vertebrae in 293 asymptomatic Chinese adult volunteers. METHODS: From May 27, 2016, to November 11, 2017, a cohort of 325 asymptomatic Chinese adults meeting the study exclusion criteria was recruited...
May 23, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29792116/the-epistemic-culture-in-an-online-citizen-science-project-programs-antiprograms-and-epistemic-subjects
#4
Dick Kasperowski, Thomas Hillman
In the past decade, some areas of science have begun turning to masses of online volunteers through open calls for generating and classifying very large sets of data. The purpose of this study is to investigate the epistemic culture of a large-scale online citizen science project, the Galaxy Zoo, that turns to volunteers for the classification of images of galaxies. For this task, we chose to apply the concepts of programs and antiprograms to examine the 'essential tensions' that arise in relation to the mobilizing values of a citizen science project and the epistemic subjects and cultures that are enacted by its volunteers...
May 1, 2018: Social Studies of Science
https://www.readbyqxmd.com/read/29792078/ethical-values-of-academic-nurses-a-pilot-study
#5
Yıldız Denat, Yurdanur Dikmen, Gülşah Gürol Arslan
BACKGROUND: While academics contribute to the development of society through all the subjects that they work on, they also have other important tasks to fulfill, such as being role models for their students and society. Therefore, the place of academic ethical values is a significant topic for academic nurses. OBJECTIVE: The main objective of this research was to examine the attitudes of academic nurses toward academic ethics. RESEARCH DESIGN: This descriptive and cross-sectional research study was conducted between March and June 2017 in three different public universities in Turkey...
January 1, 2018: Nursing Ethics
https://www.readbyqxmd.com/read/29792047/annals-express-phenotyping-and-relative-quantification-of-vitamin-d-binding-protein-in-a-pediatric-population-by-liquid-chromatography-tandem-mass-spectrometry
#6
Ana Isabel Cillero, Eduardo Martínez-Morillo, Laura Mantecón, Mª Agustina Alonso, Helena Gil-Peña, Fernando Santos, Francisco V Alvarez
BACKGROUND: Adequate levels of vitamin D are required to ensure bone health and minimize the incidence of multiple extraskeletal diseases. Although total 25-hydroxyvitamin D (25OHD) remains the recommended biomarker for assessing vitamin D status, it has been speculated that free 25OHD correlates better with clinical outcomes. The calculation of free 25OHD depends on the levels of vitamin D binding protein (DBP), the determination of which involves different immunoassays and has led to varying results and conclusions...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29791588/microrna-451a-microrna-34a-5p-and-microrna-221-3p-as-predictors-of-response-to-antidepressant-treatment
#7
Wei-Hong Kuang, Zai-Quan Dong, Lian-Tian Tian, Jin Li
Aberrant expression of microRNAs (miRNAs) has been shown to be involved in early observations of depression. The aim of this study was to determine if serum levels of miRNA-451a, miRNA-34a-5p, and miRNA-221-3p can serve as indicators of disease progression or therapeutic efficacy in depression. We collected data from 84 depressed patients and 78 control volunteers recruited from the medical staff at the West China Hospital. Depression severity was rated using the 24-item Hamilton Depression Scale (HAMD). Serum miRNA-451a, miRNA-34a-5p, and miRNA-221-3p levels were determined in samples from the depressed patients before and 8 weeks after antidepressant treatment as well as in samples from controls...
2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29791320/modelling-the-cerebral-haemodynamic-response-in-the-physiological-range-of-paco-sub-2-sub
#8
Jatinder Singh Minhas, Ronney B Panerai, Thompson G Robinson
Objective
 Arterial CO<sub>2</sub> (PaCO<sub>2</sub>) has a strong effect on cerebral blood flow (CBF), but its influence on CBF regulatory mechanisms and circulatory systemic variables has not been fully described over the entire physiological range of PaCO<sub>2</sub>. 
 
 Approach
 CBF velocity (CBV, transcranial Doppler), blood pressure (BP, Finometer) and end-tidal CO<sub>2</sub> (EtCO<sub>2</sub>, capnography) were measured in 45 healthy volunteers (19 male, mean age 37...
May 23, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29791260/assessment-of-the-power-required-for-optimal-use-of-current-inhalation-devices
#9
Gerhard Pohlmann, Jens M Hohlfeld, Peter Haidl, Jelena Pankalla, Rolf Michael Cloes
BACKGROUND: Inhalation of medications is the cornerstone in the treatment of patients with lung diseases. A variety of inhalation devices exists and each device has specific requirements to achieve optimum inhalation of the drug. The goal of this study was to establish a clear overview on performance requirements of standard inhalation devices that should be met by the patient's breathing power and to develop a new method to measure the individual performance data. MATERIALS AND METHODS: An optimum and still acceptable required breathing power (P in watts) was calculated for each device with the aid of individual device flow rates (determined by a literature search) and the flow resistances (by measuring the pressure drop over the different inhalation devices)...
May 23, 2018: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/29791029/development-of-a-3d-ultrasound-guidance-system-for-permanent-breast-seed-implantation
#10
Justin Michael, Daniel Morton, Deidre Batchelar, Michelle Hilts, Juanita Crook, Aaron Fenster
PURPOSE: Permanent breast seed implantation (PBSI) is a promising radiotherapy technique for early-stage breast cancer, completed in a single visit by permanently implanting 103 Pd seeds using needles inserted through a template and guided by 2D ultrasound (US). However, operator dependence has been highlighted as a limitation of this procedure. Consequently, we propose and have developed an intraoperative guidance system using 3D US and an instrumented mechanical arm to provide intraoperative 3D imaging and needle template tracking...
May 23, 2018: Medical Physics
https://www.readbyqxmd.com/read/29790821/effects-of-immuno-related-gene-polymorphisms-on-a-bispecific-antibody-targeting-colorectal-cancer-cell
#11
Cong-Min Zhang, Lin-Yu Yu, Jin-Feng Lv, Liang Gong, Hong-Hao Zhou, Xiao-Ping Chen, Lan Fan
BACKGROUND: Colorectal cancer (CRC) represents the third most common type of cancer and the third leading cause of death from cancer around the world. M701 is a CD3/EpCAM bispecific antibody that shows promising cytotoxicity toward CRC cells. AIM: To investigate the influence of immuno-related gene polymorphisms on M701 mediated cytotoxicity to CRC cell HCT116. METHOD: We analyzed the influence of the effect of M701 on the activation and cytotoxicity of peripheral mononuclear blood cells from 129 healthy volunteers with different genotypes...
May 23, 2018: Personalized Medicine
https://www.readbyqxmd.com/read/29790701/the-clinical-importance-of-changes-in-treg-and-th17-lymphocyte-subsets-in-splenectomized-patients-after-spleen-injury
#12
Witold Zgodziński, Ewelina Grywalska, Dorota Siwicka-Gieroba, Agata Surdacka, Krzysztof Zinkiewicz, Dariusz Szczepanek, Grzegorz Wallner, Jacek Roliński
BACKGROUND: Splenectomized patients are more prone to bacterial infections due to their immunocompromised status. Little is known about the role of T helper 17 (Th17) and T regulatory cells (Treg) in the immune system of patients after the removal of the spleen. OBJECTIVES: The aim of the present study was to analyze possible changes in CD4+ lymphocyte T subsets, especially Treg and Th17, in patients who had undergone splenectomy. MATERIAL AND METHODS: The study included a group of 67 male patients (41...
May 22, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790695/elevated-beta-thromboglobulin-and-mean-platelet-volume-levels-may-show-persistent-platelet-activation-in-systemic-lupus-erythematosus-patients
#13
Seyit Uyar, Gul Babacan Abanonu, Seval Masatlioglu Pehlevan, Cumali Karatoprak, Meral Ulukoylu Menguc, Alper Daskin, Suleyman Dolu, Refik Demirtunc
BACKGROUND: Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombotic events. Platelets become more active and they enlarge to release proteins from alpha granules for aggregation during the plaque formation period. Beta-thromboglobulin is one of the proteins released from alpha-granules when platelets are activated and used as a marker of platelet activation in vivo. OBJECTIVES: The aim of this study was to evaluate the plasma levels of beta-thromoglobulin and mean platelet volume as markers of the presence of platelet activation in systemic lupus erythematosus patients compared with healthy controls...
May 17, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29790648/anxiety-sensitivity-mediates-the-relationship-between-exercise-frequency-and-anxiety-and-depression-symptomology
#14
Joshua J Broman-Fulks, Chelsea M Abraham, Kelsey Thomas, Will H Canu, David C Nieman
The anxiolytic and antidepressant effects of regular physical exercise have been well documented, though the mechanisms through which exercise alleviates symptoms of emotion disorders require further investigation. Mounting research indicates that exercise reduces anxiety sensitivity, a known vulnerability factor for the development and maintenance of psychological disorders, presumably via repeated exposure to feared somatic sensations. The purpose of the present study was to examine whether anxiety sensitivity mediates the relation between exercise frequency and symptoms of anxiety and depression...
May 23, 2018: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/29790264/immune-responses-against-tumor-associated-antigen-derived-cytotoxic-t-lymphocyte-epitopes-in-cholangiocarcinoma-patients
#15
Akihiko Kida, Eishiro Mizukoshi, Toshikatsu Tamai, Takeshi Terashima, Masaaki Kitahara, Kuniaki Arai, Tatsuya Yamashita, Kazumi Fushimi, Masao Honda, Shuichi Kaneko
BACKGROUND & AIMS: Immunotherapy is a promising treatment option for cholangiocarcinoma. We compared cytotoxic T lymphocyte (CTL) responses against several tumor-associated antigen (TAA)-derived epitopes in cholangiocarcinoma patients to identify candidate epitopes for immunotherapy. METHODS: Twenty-six TAAs were selected, and the expression of TAAs in 6 cholangiocarcinoma cell lines and 9 specimens were measured using real-time polymerase chain reaction (PCR)...
May 23, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29790260/endogenous-glp-1-alters-postprandial-functional-connectivity-between-homeostatic-and-reward-related-brain-regions-involved-in-the-regulation-of-appetite-in-healthy-lean-males-a-pilot-study
#16
Anne Christin Meyer-Gerspach, Huynh Giao Ly, Stefan Borgwardt, Patrick Dupont, Christoph Beglinger, Lukas Van Oudenhove, Bettina K Wölnerhanssen
AIMS: Peripheral infusion of glucagon-like peptide-1 (GLP-1) can affect brain activity in areas involved in the regulation of appetite, including hypothalamic and reward-related brain regions. In contrast, the physiological role of endogenous GLP-1 in the central regulation of appetite has hardly been investigated. MATERIALS AND METHODS: The study was performed as randomized, cross-over trial. Twelve healthy volunteers received an intragastric (ig) glucose (gluc) load with or without intravenous (iv) exendin9-39 (ex9-39; specific GLP-1 receptor antagonist)...
May 22, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29790083/point-quantification-elastography-in-the-evaluation-of-liver-elasticity-in-healthy-volunteers-a-reliability-study-based-on-operator-expertise
#17
Cristina Felicani, Chiara De Molo, Horia Stefanescu, Fabio Conti, Elena Mazzotta, Veronica Gabusi, Elena Nardi, Antonio Maria Morselli-Labate, Pietro Andreone, Carla Serra
PURPOSE: The assessment of liver fibrosis is essential in the management of patients with chronic liver diseases. Liver biopsy is considered the gold standard procedure for this purpose, though the recent development of new elastosonographic techniques to measure liver stiffness (LS) noninvasively is promising. Point quantification elastography (PQE) showed good results but less is known about the level of skill needed to obtain reliable results. The aim of the study was to evaluate the reproducibility of PQE in assessing LS in healthy subjects comparing three operators with different expertise...
May 22, 2018: Journal of Ultrasound
https://www.readbyqxmd.com/read/29790062/analysis-of-pulse-signals-based-on-array-pulse-volume
#18
Ji Cui, Li-Ping Tu, Jian-Feng Zhang, Shao-Liang Zhang, Zhi-Feng Zhang, Jia-Tuo Xu
OBJECTIVE: To collect and analyze multi-dimensional pulse diagram features with the array sensor of a pressure profile system (PPS) and study the characteristic parameters of the new multi-dimensional pulse diagram by pulse diagram analysis technology. METHODS: The pulse signals at the Guan position of left wrist were acquired from 105 volunteers at the Shanghai University of Traditional Chinese Medicine. We obtained the pulse data using an array sensor with 3×4 channels...
May 22, 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29790036/variability-of-native-t1-values-implication-for-defining-regional-myocardial-changes-using-mri
#19
Kai Lin, Kenichiro Suwa, Heng Ma, Jeremy D Collins, Michael Markl, James C Carr
The aim of the present study was to establish T1 variation (T1v) thresholds for duplicated measurements of regional T1 values in left ventricle (LV) using magnetic resonance imaging (MRI). Eighteen healthy volunteers were recruited to undergo two consecutive cardiac MRI scans using modified Look-Locker Inversion recovery (MOLLI) with two spatial resolutions on different days to repeat T1 measurements on LV. The absolute differences (d) and standard deviations (SDs) of regional T1 values were acquired with the two scans and two readers...
May 22, 2018: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29789946/outcome-of-arthroscopic-slap-repair-using-knot-tying-suture-anchors-compared-with-knotless-suture-anchors-in-athletes
#20
Y Reinig, F Welsch, R Hoffmann, D Müller, K F Schüttler, E Zimmermann, Thomas Stein
INTRODUCTION: Arthroscopic repair is one option for the surgical treatment of type II superior labrum tears from anterior to posterior (SLAP) lesions in athletes' shoulders. MATERIALS AND METHODS: Sixty-one of 78 (78.2%) athletes were retrospectively examined after isolated arthroscopic SLAP repair (group 1/G1: 28x knot-tying anchors; group 2/G2: 33 knotless anchors; follow-up 24 months) and compared to two specific, separate matched volunteer athlete control groups (group 3/G3: 28 athletes matched to G1; group 4/G4: 33 athletes matched to G2)...
May 22, 2018: Archives of Orthopaedic and Trauma Surgery
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