keyword
MENU ▼
Read by QxMD icon Read
search

Volunteer

keyword
https://www.readbyqxmd.com/read/27922883/infection-oxidative-stress-and-changes-in-circulating-regulatory-t-cells-of-heart-failure-patients-supported-by-continuous-flow-ventricular-assist-devices
#1
Nandan K Mondal, Michael A Sobieski, Si M Pham, Bartley P Griffith, Steven C Koenig, Mark S Slaughter, Zhongjun J Wu
The objective of this study was to investigate the changes in oxidative stress (OS) and circulating regulatory T cells (Tregs) of the immune system in CF-VAD patients with or without infection. We recruited 16 CF-VAD patients (5 with infection and 11 without infection) and 7 healthy volunteers. Generation of reactive oxygen species (ROS) from lymphocytes, superoxide dismutase (SOD) in erythrocyte, total antioxidant capacity (TAC) and oxidized low density lipoprotein (oxLDL) in plasma were measured. Circulating Tregs were evaluated by flow cytometry...
December 2, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27922769/see-test-treat-a-5-year-experience-of-pathologists-driving-cervical-and-breast-cancer-screening-to-underserved-and-underinsured-populations
#2
Barbarajean Magnani, Beth Harubin, Judith F Katz, Andrea L Zuckerman, William C Strohsnitter
CONTEXT: - See, Test & Treat is a pathologist-driven program to provide cervical and breast cancer screening to underserved and underinsured patient populations. This program is largely funded by the CAP Foundation (College of American Pathologists, Northfield, Illinois) and is a collaborative effort among several medical specialties united to address gaps in the current health care system. OBJECTIVE: - To provide an outline for administering a See, Test & Treat program, using an academic medical center as a model for providing care and collating the results of 5 years of data on the See, Test & Treat program's findings...
December 2016: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/27922739/tyrosine-kinase-aurora-kinase-and-leucine-aminopeptidase-as-attractive-drug-targets-in-anticancer-therapy-characterisation-of-their-inhibitors
#3
Joanna Ziemska, Jolanta Solecka
Cancers are the leading cause of deaths all over the world. Available anticancer agents used in clinics exhibit low therapeutic index and usually high toxicity. Wide spreading drug resistance of cancer cells induce a demanding need to search for new drug targets. Currently, many on-going studies on novel compounds with potent anticancer activity, high selectivity as well as new modes of action are conducted. In this work, we describe in details three enzyme groups, which are at present of extensive interest to medical researchers and pharmaceutical companies...
2016: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/27922566/the-placebo-analgesic-effect-in-healthy-individuals-and-patients-a-meta-analysis
#4
June Thorvaldsen Forsberg, Monica Martinussen, Magne Arve Flaten
OBJECTIVES: The present meta-analysis investigates whether the magnitude of placebo analgesia is different in patients compared to healthy individuals and whether placebo analgesia is different in experimentally induced pain compared to clinical pain in patients. METHODS: A literature search in Web of Science (ISI) on the terms "placebo analgesia" and "placebo analgesic" was conducted. The search resulted in 71 studies, including 4239 participants. Fifty-five studies included healthy individuals and 16 studies included patients...
December 2, 2016: Psychosomatic Medicine
https://www.readbyqxmd.com/read/27922320/discrimination-between-safe-and-unsafe-stimuli-mediates-the-relationship-between-trait-anxiety-and-return-of-fear
#5
Lindsay K Staples-Bradley, Michael Treanor, Michelle G Craske
Individuals with anxiety disorders show deficits in the discrimination between a cue that predicts an aversive outcome and a safe stimulus that predicts the absence of that outcome. This impairment has been linked to increased spontaneous recovery of fear following extinction, however it is unknown if there is a link between discrimination and return of fear in a novel context (i.e. context renewal). It is also unknown if impaired discrimination mediates the relationship between trait anxiety and either spontaneous recovery or context renewal...
December 6, 2016: Cognition & Emotion
https://www.readbyqxmd.com/read/27922194/pharmacodynamic-response-profiles-of-anxiolytic-and-sedative-drugs
#6
Xia Chen, Freerk Broeyer, Marieke de Kam, Joke Baas, Adam Cohen, Joop van Gerven
INTRODUCTION: Centrally-acting acutely anxiolytic drugs, like benzodiazepines, barbiturates and gabapentinoids, affect various central nervous system (CNS) functions, which reflect not only their anxiolytic effects but also neuropsychological side-effects. To validate the pharmacodynamic biomarkers for GABA-ergic anxiolytics, this study determined the pharmacodynamics of two anxiolytics and a non-anxiolytic control and linked them to their anxiolytic and sedative effects, during an anxiety-challenge study day...
December 6, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27921357/interrelationship-between-mini-mental-state-examination-scores-and-biochemical-parameters-in-patients-with-mild-cognitive-impairment-and-alzheimer-s-disease
#7
Ramasamy Vasantharekha, Hannah P Priyanka, Thangavel Swarnalingam, Avathvadi Venkatesan Srinivasan, Srinivasan ThyagaRajan
AIM: The aim of the present study was to provide first-hand information about the prevalence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Tamil Nadu, a southern state in India, and examine if there exists a relationship between cognitive functions and biochemical parameters in these patients. METHODS: Surveys were collected from adults, older men and women (n = 3126) from different regions of Tamil Nadu, which were followed up after 12 months for 1337 participants...
December 6, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27921121/a%C3%A2-4d-ultrasound-real-time-tracking-system-for-external-beam-radiotherapy-of-upper-abdominal-lesions-under-breath-hold
#8
Dwi Seno Kuncoro Sihono, Lena Vogel, Christel Weiß, Johannes Thölking, Frederik Wenz, Frank Lohr, Judit Boda-Heggemann, Hansjörg Wertz
BACKGROUND AND PURPOSE: To evaluate a novel four-dimensional (4D) ultrasound (US) tracking system for external beam radiotherapy of upper abdominal lesions under computer-controlled deep-inspiration breath-hold (DIBH). MATERIALS AND METHODS: The tracking accuracy of the research 4D US system was evaluated using two motion phantoms programmed with sinusoidal and breathing patterns to simulate free breathing and DIBH. Clinical performance was evaluated with five healthy volunteers...
December 5, 2016: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/27920999/frequency-of-y-chromosome-microdeletions-among-iranian-infertile-men-with-azoospermia-and-severe-oligozoospermia-a-meta-analysis
#9
Ehsan Yousefi-Razin, Mohammad Javad Nasiri, Mir Davood Omrani
BACKGROUND: While multiple factors can contribute to male infertility, genetic factors, such as chromosomal disorders or Y-chromosome microdeletion, are responsible for about 10% of male infertility. Considering the role of Y-chromosome micro-deletions in men with oligozoospermia who volunteer for in vitro fertilization (IVF), the prevalence of such microdeletions in each particular community needs to be exactly determined. Hence, the present study attempted to analyze the available literature on the frequency of chromosome microdeletion among Iranian infertile men...
October 2016: Journal of Reproduction & Infertility
https://www.readbyqxmd.com/read/27920888/development-of-a-high-resolution-melting-analysis-method-for-cyp2c19-17-genotyping-in-healthy-volunteers
#10
Zahra Ghasemi, Mehrdad Hashemi, Mahsa Ejabati, Seyyed Meisam Ebrahimi, Hamidreza Kheiri Manjili, Ali Sharafi, Ali Ramazani
BACKGROUND: Genetic polymorphisms of drug metabolisms by cytochrome P450 (P450s) could affect drug response, attracting particular interest in the pharmacogenetics. Due to the importance of CYP2C19* 17 allele and its capability of super- fast metabolism and also lack of information about distribution of the alleles in Iranian population, this research aimed to use High Resolution Melting (HRM) method compared to PCR-RFLP for genotyping healthy Iranian population. METHODS: Blood samples were collected from 100 healthy Iranian volunteers...
October 2016: Avicenna Journal of Medical Biotechnology
https://www.readbyqxmd.com/read/27920264/activities-in-dementia-care-a-comparative-assessment-of-activity-types
#11
Elizabeth Lokon, Philip E Sauer, Yue Li
This exploratory study compares the impact of five activity types on the well-being of institutionalized people with dementia: the intergenerational art program Opening Minds through Art, art and music therapies, creative activities, non-creative activities, and no activities at all. We validated the Scripps Modified Greater Cincinnati Chapter Well-Being Observational Tool, and used that instrument to systematically observe N = 67 people with dementia as they participated in different activity types. People with dementia showed the highest well-being scores during Opening Minds through Art compared to all other activities...
December 5, 2016: Dementia
https://www.readbyqxmd.com/read/27920258/the-effects-of-three-different-exercise-modalities-on-markers-of-male-reproduction-in-healthy-subjects-a-randomized-controlled-trial
#12
Behzad Hajizadeh Maleki, Bakhtyar Tartibian, Mohammad Chehrazi
The aim of this study was to investigate the effects of moderate-intensity continuous training (MICT), high-intensity continuous training (HICT) and high-intensity interval training (HIIT) on markers of male reproduction including seminal markers of oxidative stress and inflammation as well as semen quality and sperm DNA integrity in healthy human subjects. A total of 397 healthy male volunteers were screened and 280 were randomly assigned to one of the MICT (n = 70), HICT (n = 70), HIIT (n = 70) and non-exercise (NON-EX, n = 70) groups...
February 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/27919977/microrna-7-is-associated-with-malignant-potential-and-poor-prognosis-in-human-colorectal-cancer
#13
Yuka Nagano, Yuji Toiyama, Yoshinaga Okugawa, Hiroki Imaoka, Hiroyuki Fujikawa, Hiromi Yasuda, Shigeyuki Yoshiyama, Junichiro Hiro, Minako Kobayashi, Masaki Ohi, Toshimitsu Araki, Yasuhiro Inoue, Yasuhiko Mohri, Masato Kusunoki
Dysregulation pattern of microRNA-7 (miR-7) and the clinical significance of its expression in colorectal cancer (CRC) are unresolved. Here, we investigated the relationship between clinicopathological factors, including prognostic outcome, and miR-7 expression in CRC tissues. We analyzed miR-7 expression levels by real-time reverse transcription polymerase chain reaction in 210 colorectal tissues (196 CRCs and 14 normal mucosae from healthy volunteers). miR-7 expression levels were significantly up-regulated in CRC tissues compared to normal colorectal mucosae...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919960/dancr-acts-as-a-diagnostic-biomarker-and-promotes-tumor-growth-and-metastasis-in-hepatocellular-carcinoma
#14
Xiang Ma, Xin Wang, Chao Yang, Zusen Wang, Bing Han, Liqun Wu, Likun Zhuang
BACKGROUND: Long non-coding RNA differentiation antagonizing non-protein coding RNA (DANCR) is considered to be an oncogene in many cancer types. However, the role of DANCR in diagnosis and progression of hepatocellular carcinoma (HCC) is still unknown. PATIENTS AND METHODS: In this study, 146 participants including healthy volunteers (HVs) and patients with chronic hepatitis B (CHB), cirrhosis and HCC were recruited. RESULTS: Firstly, quantitative reverse transcription-PCR analysis showed that DANCR was up-regulated in tumor tissues and plasma of patients with HCC, and its expression was highly correlated with microvascular and liver capsule invasion of HCC...
December 2016: Anticancer Research
https://www.readbyqxmd.com/read/27919626/targeted-delivery-of-glucocorticoids-to-macrophages-in-a-mouse-model-of-multiple-sclerosis-using-inorganic-organic-hybrid-nanoparticles
#15
Elena Montes-Cobos, Sarah Ring, Henrike J Fischer, Joachim Heck, Judith Strauß, Markus Schwaninger, Sybille D Reichardt, Claus Feldmann, Fred Lühder, Holger M Reichardt
Glucocorticoids (GC) are widely used to treat acute relapses in multiple sclerosis (MS) patients, but their application is accompanied by side effects due to their broad spectrum of action. Here, we report on the therapeutic option to apply GC via inorganic-organic hybrid nanoparticles (IOH-NP) with the composition [ZrO](2+)[(BMP)0.9(FMN)0.1](2-) (designated BMP-NP with BMP: betamethasone phosphate; FMN: flavinmononucleotide). We found that these BMP-NP have an increased cell type-specificity compared to free GC while retaining full therapeutic efficacy in a mouse model of MS...
December 2, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27919546/brain-morphometry-predicts-individual-creative-potential-and-the-ability-to-combine-remote-ideas
#16
David Bendetowicz, Marika Urbanski, Clarisse Aichelburg, Richard Levy, Emmanuelle Volle
For complex mental functions such as creative thinking, inter-individual variability is useful to better understand the underlying cognitive components and brain anatomy. Associative theories propose that creative individuals have flexible semantic associations, which allows remote elements to be formed into new combinations. However, the structural brain variability associated with the ability to combine remote associates has not been explored. To address this question, we performed a voxel-based morphometry (VBM) study and explored the anatomical connectivity of significant regions...
November 15, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/27919522/quantitative-assessment-of-healthy-skin-elasticity-reliability-and-feasibility-of-shear-wave-elastography
#17
Xi Xiang, Feng Yan, Yujia Yang, Yuanjiao Tang, Liyun Wang, Jia Zeng, Li Qiu
The goal of this study was to investigate the reliability and feasibility of shear wave elastography by assessing the elasticity of the healthy skin of 40 volunteers. Young's moduli for bilateral fingers, forearms, anterior chest (sternum), and anterior abdomen were determined with both transverse and longitudinal sectional measurements. Reliability of measurements was evaluated using intra- and inter-class correlation coefficients with two observers. Our results revealed that the elastic modulus values of the skin between symmetric parts of fingers and forearms did not statistically different...
December 2, 2016: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/27918976/randomized-controlled-trial-of-a-family-oriented-self-management-program-to-improve-self-efficacy-glycemic-control-and-quality-of-life-among-thai-individuals-with-type-2-diabetes
#18
Nutchanath Wichit, George Mnatzaganian, Mary Courtney, Paula Schulz, Maree Johnson
AIMS: We evaluated a theoretically-derived family-oriented intervention aimed to improve self-efficacy, self-management, glycemic control and quality of life in individuals living with Type 2 diabetes in Thailand. METHODS: In a single-blinded randomized controlled trial, 140 volunteer individuals with Type 2 diabetes, recruited from a diabetes clinic in rural Thailand, were randomly allocated to intervention and control arms. Those in the intervention arm received routine care plus a family-oriented program that included education classes, group discussions, a home visit, and a telephone follow-up while the control arm only received routine care...
November 19, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27918880/racial-differences-in-hiv-and-hcv-risk-behaviors-transmission-and-prevention-knowledge-among-non-treatment-seeking-individuals-with-opioid-use-disorder
#19
Verena E Metz, Maria A Sullivan, Jermaine D Jones, Elizabeth Evans, Rachel Luba, Jonathan Vogelman, Sandra D Comer
In light of New York's recently reinforced strategy to end the AIDS epidemic by expanding testing, treatment, and access to pre-exposure prophylaxis (PrEP), we assessed drug use and sexual risk behaviors, along with HIV/Hepatitis C virus (HCV) transmission and prevention knowledge among non-treatment-seeking adults with opioid use disorder (OUD) in New York City. Over the course of 18 months, volunteers screening for research studies in the Opioid Laboratory at the New York State Psychiatric Institute completed a locally developed self-assessment questionnaire...
December 5, 2016: Journal of Psychoactive Drugs
https://www.readbyqxmd.com/read/27918749/correlation-of-nasal-mucosal-temperature-with-subjective-nasal-patency-in-healthy-individuals
#20
Ryan S Bailey, Kevin P Casey, Sachin S Pawar, Guilherme J M Garcia
Importance: Historically, otolaryngologists have focused on nasal resistance to airflow and minimum airspace cross-sectional area as objective measures of nasal obstruction using methods such as rhinomanometry and acoustic rhinometry. However, subjective sensation of nasal patency may be more associated with activation of cold receptors by inspired air than with respiratory effort. Objective: To investigate whether subjective nasal patency correlates with nasal mucosal temperature in healthy individuals...
December 1, 2016: JAMA Facial Plastic Surgery
keyword
keyword
8328
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"