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https://www.readbyqxmd.com/read/29684249/standard-head-down-tilt-versus-modified-without-head-down-tilt-postural-drainage-in-infants-and-young-children-with-cystic-fibrosis
#1
REVIEW
Diana A Freitas, Gabriela Ss Chaves, Thayla A Santino, Cibele Td Ribeiro, Fernando Al Dias, Ricardo O Guerra, Karla Mpp Mendonça
BACKGROUND: Postural drainage is used primarily in infants with cystic fibrosis from diagnosis up to the moment when they are mature enough to actively participate in self-administered treatments. However, there is a risk of gastroesophageal reflux associated with this technique.This is an update of a review published in 2015. OBJECTIVES: To compare the effects of standard postural drainage (15º to 45º head-down tilt) with modified postural drainage (15º to 30º head-up tilt) with regard to gastroesophageal reflux in infants and young children up to six years old with cystic fibrosis in terms of safety and efficacy...
March 9, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29684129/insights-into-rna-processing-pathways-and-associated-rna-degrading-enzymes-in-archaea
#2
Béatrice Clouet-d'Orval, Manon Batista, Marie Bouvier, Yves Quentin, Gwennaele Fichant, Anita Marchfelder, Lisa-Katharina Maier
RNA processing pathways are at the center of regulation of gene expression. All RNA transcripts undergo multiple maturation steps in addition to covalent chemical modifications to become functional in the cell. This includes destroying unnecessary or defective cellular RNAs. In Archaea, information on mechanisms by which RNA species reach their mature forms and associated RNA-modifying enzymes is still fragmentary. To date, most archaeal actors and pathways have been proposed in light of information gathered from Bacteria and Eukarya...
April 19, 2018: FEMS Microbiology Reviews
https://www.readbyqxmd.com/read/29683997/pancreaticojejunostomy-versus-pancreaticogastrostomy-after-pancreaticoduodenectomy-an-up-to-date-meta-analysis-of-rcts-applying-the-isgps-2016-criteria
#3
Yunxiao Lyu, Ting Li, Yunxiao Cheng, Bin Wang, Liang Chen, Sicong Zhao
The goal of our study was to compare the impact of pancreaticogastrostomy (PG) versus pancreaticojejunostomy (PJ) on the incidence of complications after pancreaticoduodenectomy. A systematic search was performed using RevMan 5.3 software. A meta-analysis showed that PG was not superior to PJ in terms of postoperative pancreatic fistula (POPF). In multicenter randomized controlled trials, the incidence of POPF was lower in patients undergoing PG than in those undergoing PJ. However, PG was associated with an increased risk of postoperative intraluminal hemorrhage, but no significant difference was observed between 2-layer PG and PJ...
April 20, 2018: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/29683494/the-fragility-of-statistically-significant-findings-from-randomized-trials-in-head-and-neck-surgery
#4
Christopher W Noel, Caitlin McMullen, Christopher Yao, Eric Monteiro, David P Goldstein, Antoine Eskander, John R de Almeida
OBJECTIVES: The Fragility Index (FI) is a novel tool for evaluating the robustness of statistically significant findings in a randomized control trial (RCT). It measures the number of events upon which statistical significance depends. We sought to calculate the FI scores for RCTs in the head and neck cancer literature where surgery was a primary intervention. DATA SOURCES: Potential articles were identified in PubMed (MEDLINE), Embase, and Cochrane without publication date restrictions...
April 23, 2018: Laryngoscope
https://www.readbyqxmd.com/read/29683458/isolation-of-human-endothelial-cells-from-normal-colon-and-colorectal-carcinoma-an-improved-protocol
#5
Elisabeth Naschberger, Daniela Regensburger, Clara Tenkerian, Melanie Langheinrich, Felix B Engel, Carol Geppert, Arndt Hartmann, Robert Grützmann, Vera S Schellerer, Michael Stürzl
Primary cells isolated from human carcinomas are valuable tools to identify pathogenic mechanisms contributing to disease development and progression. In particular, endothelial cells (EC) constituting the inner surface of vessels, directly participate in oxygen delivery, nutrient supply, and removal of waste products to and from tumors, and are thereby prominently involved in the constitution of the tumor microenvironment (TME). Tumor endothelial cells (TECs) can be used as cellular biosensors of the intratumoral microenvironment established by communication between tumor and stromal cells...
April 4, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29683412/225-intracranial-aneurysms-treated-with-the-low-profile-visualized-intraluminal-support-lvis-stent-a-single-center-retrospective-study
#6
Wei Su, Yisen Zhang, Junfan Chen, Jian Liu, Gary Rajah, Xinjian Yang
Background For the treatment of intracranial aneurysms, the low-profile visualized intraluminal support (LVIS) stent is a new generation of highly visible-braided stent that was recently introduced in China. Here, we report our single-center retrospective experience of safety and efficacy utilizing LVIS for stent-assisted coiling of intracranial aneurysms. Methods We included 218 patients with intracranial aneurysms consecutively treated with LVIS SR stents at our center in this study. Postoperative and follow-up embolization scores, procedural complications, clinical and angiographic findings at mid-term follow-up, as well as recurrence rate, preoperative and follow-up mRS scores were analyzed...
April 23, 2018: Neurological Research
https://www.readbyqxmd.com/read/29682740/implications-of-false-positive-results-for-future-cancer-screenings
#7
Glen B Taksler, Nancy L Keating, Michael B Rothberg
BACKGROUND: False-positive cancer screening results may affect a patient's willingness to obtain future screening. METHODS: The authors conducted logistic regression analysis of 450,484 person-years of electronic medical records (2006-2015) in 92,405 individuals aged 50 to 75 years. Exposures were false-positive breast, prostate, or colorectal cancer screening test results (repeat breast imaging or negative breast biopsy ≤3 months after screening mammography, repeat prostate-specific antigen [PSA] test ≤3 months after PSA test result ≥4...
April 23, 2018: Cancer
https://www.readbyqxmd.com/read/29682495/obesity-and-overweight-among-brazilian-early-adolescents-variability-across-region-socioeconomic-status-and-gender
#8
Chris Fradkin, Nadia C Valentini, Glauber C Nobre, João O L Dos Santos
Introduction: As with most emerging nations, Brazil lacks up-to-date data on the prevalence of obesity and overweight among its children. Of particular concern is the lack of data on children in early adolescence, considered by many to be the crucial stage for weight-related healthcare. Objective: To assess regional, socioeconomic, and gender differences in the prevalence of obesity and overweight among Brazilian early adolescents. Methods: A cross-sectional study was conducted on a racially diverse sample of students aged 10-13 years, from schools in three geographic regions (north, northeast, south) ( N  = 1,738)...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29682469/conservative-management-versus-endovascular-or-open-surgery-in-the-spectrum-of-type-b-aortic-dissection
#9
Xun Yuan, Andreas Mitsis, Mohammed Ghonem, Ilias Iakovakis, Christoph A Nienaber
Background: Type B aortic dissection is a life-threatening acute aortic condition often with acute ischemic signs or symptoms. With initial management focusing on alleviating malperfusion and pain, and avoiding propagation of dissection or rupture both systolic blood and pulse pressure should be reduced initially by an aggressive medical approach. In the setting of persistent signs of complications endovascular strategies have replaced open surgery and led to a fourfold increase in early survival and better long-term outcomes...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29682298/tenofovir-alafenamide-versus-tenofovir-disoproxil-fumarate-is-there-a-true-difference-in-efficacy-and-safety
#10
EDITORIAL
Andrew Hill, Sophie L Hughes, Dzintars Gotham, Anton L Pozniak
Background: Higher plasma tenofovir concentrations are associated with higher risks of renal and bone adverse events. The pharmacokinetic boosters ritonavir (RTV) and cobicistat (COBI) significantly increase plasma area under the curve (AUC) concentrations of tenofovir disoproxil fumarate (TDF), by 25-37%. When combined with RTV or COBI, the dose of tenofovir alafenamide (TAF) is lowered from 25 mg to 10 mg daily, but the TDF dose is maintained at 300 mg daily. Objective: To assess the differences in safety and efficacy between tenofovir alafenamide (TAF) and tenofovir disoproxil fumarate (TDF) in regimens with and without the pharmacokinetic boosters RTV and COBI...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29682297/safety-and-pharmacokinetics-of-dolutegravir-in-hiv-positive-pregnant-women-a-systematic-review
#11
EDITORIAL
Andrew Hill, Polly Clayden, Claire Thorne, Rachel Christie, Rebecca Zash
Background: The integrase strand transfer inhibitor dolutegravir (DTG) is being introduced into low- and middle-income countries (LMICs) as an alternative to first-line treatment with non-nucleoside reverse transcriptase inhibitors. However, DTG is not yet widely recommended for use in pregnant women. The aim of this systematic review was to analyse all available data on birth outcomes and congenital anomalies in the infants of pregnant women treated with DTG. Methods: A PubMed and Embase search was conducted using the terms "dolutegravir" or "DTG" and "pregnancy" or "pregnant" from the earliest available date on the database to 26 July 2017...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29681480/outcome-of-endodontic-surgery-a-meta-analysis-of-the-literature-part-3-comparison-of-endodontic-microsurgical-techniques-with-2-different-root-end-filling-materials
#12
REVIEW
Meetu R Kohli, Homayon Berenji, Frank C Setzer, Su-Min Lee, Bekir Karabucak
INTRODUCTION: The aim of the present study was to investigate the influence of root-end preparation and filling material on endodontic surgery outcome. A systematic review and meta-analysis was conducted to determine the outcome of resin-based endodontic surgery (RES, the use of high-magnification preparation of a shallow and concave root-end cavity and bonded resin-based root-end filling material) versus endodontic microsurgery (EMS, the use of high-magnification ultrasonic root-end preparation and root-end filling with SuperEBA [Keystone Industries, Gibbstown, NJ], IRM [Dentsply Sirona, York, PA], mineral trioxide aggregate [MTA], or other calcium silicate cements)...
April 19, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29681452/risk-of-fractures-in-youths-with-celiac-disease-a-population-based-study
#13
Cristina Canova, Gisella Pitter, Loris Zanier, Lorenzo Simonato, Karl Michaelsson, Jonas F Ludvigsson
OBJECTIVE: To assess the risk of any fracture requiring hospital care in a cohort of individuals with celiac disease diagnosed in childhood/adolescence compared with reference individuals matched by age and sex. STUDY DESIGN: Our study cohort consisted of 213 635 people born and residing in Friuli-Venezia Giulia Region, Italy, in 1989-2011. We selected, through pathology reports, hospital discharge records, or co-payment exemptions, 1233 individuals with celiac disease (aged 0-17 years at diagnosis) and compared them with 6167 reference individuals matched by sex and year of birth...
April 19, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29681426/tumor-inherent-interferons-impact-on-immune-reactivity-and-immunotherapy
#14
Natasha K Brockwell, Belinda S Parker
Immunotherapy has revolutionized cancer treatment, with sustained responses to immune checkpoint inhibitors reported in a number of malignancies. Such therapeutics are now being trialed in aggressive or advanced cancers that are heavily reliant on untargeted therapies, such as triple negative breast cancer. However, responses have been underwhelming to date and are very difficult to predict, leading to an inability to accurately weigh up the benefit-to-risk ratio for their implementation. The tumor immune microenvironment has been closely linked to immunotherapeutic response, with superior responses observed in patients with T cell-inflamed or 'hot' tumors...
April 19, 2018: Cytokine
https://www.readbyqxmd.com/read/29680650/feeding-increasing-amounts-of-ruminally-protected-choline-decreased-fatty-liver-in-nonlactating-pregnant-holstein-cows-in-negative-energy-status
#15
M G Zenobi, T L Scheffler, J E Zuniga, M B Poindexter, S R Campagna, H F Castro Gonzalez, A T Farmer, B A Barton, J E P Santos, C R Staples
The objectives were to determine the optimal feeding amount of choline in a ruminally protected form to reduce the triacylglycerol (TAG) concentration in liver and to increase TAG in blood plasma of dairy cows. Pregnant, nonlactating multiparous Holstein cows (n = 77) were blocked by body condition score (3.59 ± 0.33) and assigned to treatment at 64 ± 10 d before calculated calving date. Dietary treatments were top-dressing of 0, 30, 60, 90, or 120 g/d of ruminally protected choline (RPC; Balchem Corp., New Hampton, NY) ions to supply the equivalent of 0, 6...
April 18, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29680328/epidemiology-of-ulnar-collateral-ligament-reconstruction-in-major-and-minor-league-baseball-pitchers-comprehensive-report-of-1429-cases
#16
Christopher L Camp, Stan Conte, John D'Angelo, Stephen A Fealy
BACKGROUND: The primary purpose of this work is to provide an epidemiologic report on every known ulnar collateral ligament (UCL) reconstruction performed in professional baseball with a special focus on outcomes and survivorship. METHODS: Three resources, including the Major League Baseball (MLB) injury tracking system, were combined and cross-referenced to identify all known professional baseball pitchers who had ever undergone UCL reconstruction from 1974 to 2016...
May 2018: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/29680111/boulder-food-rescue-an-innovative-approach-to-reducing-food-waste-and-increasing-food-security
#17
Craig A Sewald, Elena S Kuo, Hana Dansky
Food waste and food insecurity are both significant issues in communities throughout the U.S., including Boulder, Colorado. As much as 40% of the food produced in the U.S. goes uneaten and ends up in landfills. Nearly 13% of people in the Boulder region experience some level of food insecurity. Founded in 2011, Boulder Food Rescue supports community members to create their own food security through a participatory approach to an emergency food system. The organization uses a web-application "robot" to manage a schedule of volunteers...
May 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29679771/extracorporeal-photopheresis-improves-survival-in-hematopoietic-cell-transplant-patients-with-bronchiolitis-obliterans-syndrome-without-significantly-impacting-measured-pulmonary-functions
#18
Mehrdad Hefazi, Kimberly J Langer, Nandita Khera, Jill Adamski, Vivek Roy, Jeffrey L Winters, Dennis A Gastineau, Eapen K Jacob, Justin D Kreuter, Manish J Gandhi, William J Hogan, Mark R Litzow, Shahrukh K Hashmi, Hemang Yadav, Vivek N Iyer, J P Scott, Mark E Wylam, Rodrigo Cartin-Ceba, Mrinal M Patnaik
We carried out the first matched retrospective cohort study aimed at studying the safety and efficacy of extracorporeal photopheresis (ECP) for bronchiolitis obliterans syndrome (BOS) following allogeneic hematopoietic cell transplantation (HCT). Medical records of 1325 consecutive adult patients who underwent HCT between 2005 and 2015 were reviewed. Seventy-four patients (median age, 51 years) with a diagnosis of BOS were included in the study. After propensity-score matching for BOS severity, 26 patients who underwent ≥3 months of ECP were matched to 26 non-ECP-treated patients, who were assigned an index date corresponding to the ECP start date for their matched pairs...
April 18, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29679724/harvest-and-trade-of-caterpillar-mushroom-ophiocordyceps-sinensis-and-the-implications-for-sustainable-use-in-the-tibet-region-of-southwest-china
#19
Jun He
ETHNOPHARMACOLOGICAL RELEVANCE: caterpillar mushroom (Ophiocordyceps sinensis) is a unique medicinal fungi which is only found in alpine grasslands in Himalayan mountain regions and the Tibetan Plateau. Known locally as Yartsa Gunbu, it has been widely used in Tibetan and Chinese Medicine for centuries. It is crucial to understand local commercial harvest and trade practices of caterpillar mushroom to support the sustainable management of this valuable resource. However, data derived from empirically grounded research is currently limited, particularly in China...
April 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29679170/light-localization-with-low-contrast-targets-in-a-patient-implanted-with-a-suprachoroidal-transretinal-stimulation-retinal-prosthesis
#20
Takao Endo, Takashi Fujikado, Masakazu Hirota, Hiroyuki Kanda, Takeshi Morimoto, Kohji Nishida
PURPOSE: To evaluate the improvement in targeted reaching movements toward targets of various contrasts in a patient implanted with a suprachoroidal-transretinal stimulation (STS) retinal prosthesis. METHODS: An STS retinal prosthesis was implanted in the right eye of a 42-year-old man with advanced Stargardt disease (visual acuity: right eye, light perception; left eye, hand motion). In localization tests during the 1-year follow-up period, the patient attempted to touch the center of a white square target (visual angle, 10°; contrast, 96, 85, or 74%) displayed at a random position on a monitor...
April 20, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
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