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https://www.readbyqxmd.com/read/27913882/early-treatment-response-to-transcatheter-arterial-chemoembolization-is-associated-with-time-to-the-development-of-extrahepatic-metastasis-and-overall-survival-in-intermediate-stage-hepatocellular-carcinoma
#1
Sung Won Lee, Hae Lim Lee, Nam Ik Han, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon
PURPOSE: Transcatheter arterial chemoembolization (TACE) is the treatment of choice for intermediate-stage hepatocellular carcinoma (HCC). The absence of an early response to TACE might indicate alternative therapeutic strategies early in the course of the disease, thus improving outcomes. Therefore, our purpose was to identify the relationship between treatment response after two sessions of TACE and the time to the development of extrahepatic metastasis and overall survival. METHODS: In total, 108 treatment-naïve intermediate-stage HCC patients who received at least two consecutive sessions of TACE as the first-line treatment were analyzed...
December 2, 2016: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/27911268/texture-analysis-of-intermediate-advanced-hepatocellular-carcinoma-prognosis-and-patients-selection-of-transcatheter-arterial-chemoembolization-and-sorafenib
#2
Sirui Fu, Shuting Chen, Changhong Liang, Zaiyi Liu, Yanjie Zhu, Yong Li, Ligong Lu
Transcatheter arterial chemoembolization (TACE) and sorafenib combination treatment for unselected hepatocellular carcinoma (HCC) is controversial. We explored the potential of texture analysis for appropriate patient selection. There were 261 HCCs included (TACE group: n = 197; TACE plus sorafenib (TACE+Sorafenib) group n = 64). We applied a Gabor filter and wavelet transform with 3 band-width responses (filter 0, 1.0, and 1.5) to portal-phase computed tomography (CT) images of the TACE group. Twenty-one textural parameters per filter were extracted from the region of interests delineated around tumor outline...
November 29, 2016: Oncotarget
https://www.readbyqxmd.com/read/27909955/suppressive-effects-of-dabrafenib%C3%A2-on-endothelial-protein-c-receptor-shedding
#3
Sae-Kwang Ku, Jongdoo Kim, Sang Chan Kim, Jong-Sup Bae
Beyond its role in the activation of protein C, the endothelial cell protein C receptor (EPCR) plays an important role in the cytoprotective pathway. EPCR can be shed from the cell surface, which is mediated by tumor necrosis factor-α converting enzyme (TACE). Dabrafenib (DAB) is a B-Raf inhibitor and initially used for the treatment of metastatic melanoma therapy. However, little is known about the effects of DAB on EPCR shedding. We investigated this issue by monitoring the effects of DAB on phorbol-12-myristate 13-acetate (PMA)-, tumor necrosis factor (TNF)-α-, interleukin (IL)-1β-induced EPCR shedding in human umbilical vein endothelial cells (HUVECs), and cecal ligation and puncture (CLP)-mediated EPCR shedding in mice and underlying mechanism...
December 1, 2016: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/27905019/multi-disciplinary-concurrent-management-of-recurrent-hepatocellular-therapy-is-superior-to-sequential-therapy
#4
Tyler D Fields, Prejesh Philips, Charles R Scoggins, Cliff Tatum, Lawrence Kelly, Kelly M McMasters, Robert C G Martin
BACKGROUND: Recurrent hepatocellular carcinoma after a patient's initial therapy, whether it is transplantation, resection, or ablation, remains a challenging clinical problem. Since recurrence occurs in 70% of all initially treated disease within 5 years, optimal management to treat this recurrence is needed. Currently, a bias exists toward mono-therapy (i.e., ablation alone, hepatic arterial therapy alone, or sorafenib therapy alone) instead of concurrent sequential therapy-as is common in other primary and metastatic disease to the liver...
November 30, 2016: World Journal of Surgery
https://www.readbyqxmd.com/read/27904836/pulmonary-complications-of-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma
#5
Quan M Nhu, Harry Knowles, Paul J Pockros, Catherine T Frenette
Transarterial chemoembolization (TACE) is an effective palliative intervention that is widely accepted for the management of hepatocellular carcinoma (HCC). Post-TACE pulmonary complications resulting in acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) are rare events. Pulmonary complications after TACE are thought to be related to chemical injury subsequent to the migration of the infused ethiodized oil or chemotherapeutic agent to the lung vasculature, facilitated by arteriovenous (AV) shunts within the hyper-vascular HCC...
2016: World Journal of Respirology
https://www.readbyqxmd.com/read/27904450/survival-of-patients-with-intermediate-stage-hepatocellular-carcinoma-treated-with-superselective-transarterial-chemoembolization-using-doxorubicin-loaded-dc-bead-under-cone-beam-computed-tomography-control
#6
Peter Popovic, Borut Stabuc, Rado Jansa, Manca Garbajs
BACKGROUND: The purpose of this retrospective study was to evaluate treatment response, adverse events and survival rates of patients with intermediate stage HCC treated with superselective doxorubicin-loaded DC Bead transarterial chemoembolization (DEBDOX) under cone beam computed tomography (CBCT) control. PATIENTS AND METHODS: Between October 2010 and June 2012, 35 consecutive patients with intermediate stage HCC (32 male, 3 female; average age, 67.5 ± 7.8 years; 22 patients Child-Pugh class A, 8 class B, 5 without cirrhosis) were treated with DEBDOX TACE...
December 1, 2016: Radiology and Oncology
https://www.readbyqxmd.com/read/27899782/-trans-arterial-chemoembolization-therapy-for-giant-cholangiocellular-carcinoma-a-single-case-report
#7
Keita Yamashiro, Astushi Hori, Takeo Yuki, Ryosuke Ohira, Shinichi Hori
Here, we report a case of cholangiocellular carcinoma that was successfully treated with chemotherapy using a selective intra-arterial infusion technique. A 65-year-old man presented to our hospital to obtain a second opinion regarding his disease. The patient was diagnosed with cholangiocellular carcinoma. The giant tumor was located in the porta hepatis. Some small nodules that were considered to be metastatic lesions were also observed in the surroundingarea. The tumor was judged by the primary physician to be too large for surgical treatment...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27899780/-a-case-of-successful-drug-eluting-microsphere-transcatheter-arterial-embolization-for-hepatocellular-carcinoma-with-associated-tumor-thrombus-in-the-inferior-vena-cava-and-right-atrium
#8
Katsuya Takechi, Shinichi Hori, Keita Yamashiro, Takeo Yuki, Atsushi Hori
Hepatocellular carcinoma(HCC)with severe vascular invasion has a dismal prognosis, and there is no well-established effective therapy. We report an 84-year-old man who benefited from multiple transcatheter arterial chemoembolization (TACE)treatments for advanced HCC with severe vascular invasion. Initial CT revealed a recurrent, poorly differentiated HCC with tumor thrombus in the inferior vena cava(IVC)and right atrium(Vv3). Two cycles of TACE with 5-FU, DOC, MMC, and superabsorbent polymer microspheres(SAP-MS)with BV resulted in considerable reduction of the tumor thrombus...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27895495/predictive-values-of-diffusion-weighted-imaging-and-perfusion-weighted-imaging-in-evaluating-the-efficacy-of-transcatheter-arterial-chemoembolization-for-hepatocellular-carcinoma
#9
Min Lin, Man-Man Tian, Wei-Ping Zhang, Li Xu, Ping Jin
This study explored the predictive values of diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) in evaluating the efficacy of transcatheter arterial chemoembolization (TACE) for patients with hepatocellular carcinoma (HCC). A total of 118 HCC patients treated with TACE were selected from April 2013 to November 2015. T1-weighted imaging (T1WI)/T2-weighted imaging (T2WI), DWI, and PWI were performed on all patients before and after TACE. Efficacy was evaluated according to modified Response Evaluation Criteria in Solid Tumors 1...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27895433/complete-response-with-sorafenib-and-transcatheter-arterial-chemoembolization-in-unresectable-hepatocellular-carcinoma
#10
Michitoshi Takano, Takashi Kokudo, Yoshihiro Miyazaki, Yumiko Kageyama, Amane Takahashi, Katsumi Amikura, Hirohiko Sakamoto
Patients with advanced hepatocellular carcinoma (HCC) showing portal vein tumor thrombosis (PVTT) have an extremely poor prognosis. According to treatment guidelines, the only option for HCC patients with PVTT is sorafenib chemotherapy. However, in Asia, various treatments have been attempted and possible prolongation of overall survival has been repeatedly reported. We herein report the first case of a patient with an initially unresectable advanced HCC with PVTT who underwent curative hepatectomy after sorafenib and transcatheter arterial chemoembolization (TACE) showing complete histological response...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27894729/effect-of-diagnostic-cone-beam-computed-tomography-protocols-on-image-quality-patient-dose-and-lesion-detection
#11
Jijo Paul, Annamma Chacko, Paola Saccomandi, Thomas J Vogl, Nour-Eldin A Nour-Eldin
OBJECTIVE: To evaluate the effect of cone-beam computed tomography (CBCT) image acquisition protocols on image quality, lesion detection, delineation, and patient dose. METHODS: 100-patients and a CTDI phantom combined with an electron density phantom were examined using four different CBCT-image acquisition protocols during image-guided transarterial chemoembolization (TACE). Protocol-1 (time: 6s, tube rotation: 360°), protocol-2 (5s, 300°), protocol-3 (4s, 240°) and protocol-4 (3s, 180°) were used...
November 25, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27893491/role-of-low-molecular-weight-heparins-in-prevention-of-thromboembolic-complication-after-transarterial-chemoembolization-in-hepatocellular-carcinoma
#12
Osama Negm, Sabry Abou Saif, Mohamed El Gharib, Mohamed Yousef, Sherief Abd-Elsalam
BACKGROUND AND AIM: Portal vein thrombosis (PVT) is a common complication after transarterial chemoembolization (TACE) in hepatocellular carcinoma (HCC). This is the first clinical study to evaluate the role of low-molecular-weight heparins (LMWHs) with TACE in HCC for the prevention of thromboembolism complications (PVT). PATIENTS AND METHODS: This study was carried out on 40 patients with HCC requiring TACE who presented to the Tropical Medicine Department, Tanta University and Interventional Radiology Department of Ain-Shams University Hospitals starting from April 2015...
November 23, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27882236/improved-survival-with-double-platinum-therapy-transcatheter-arterial-infusion-using-cisplatin-and-transcatheter-arterial-chemoembolization-using-miriplatin-for-bclc-b-hepatocellular-carcinoma
#13
Toru Ishikawa, Satoshi Abe, Takayuki Watanabe, Yujiro Nozawa, Tomoe Sano, Akito Iwanaga, Keiichi Seki, Terasu Honma, Toshiaki Yoshida
Transcatheter arterial chemoembolization (TACE) is the standard therapy for Barcelona Clinic Liver Cancer (BCLC) classification intermediate stage B hepatocellular carcinoma (HCC). However, other transcatheter methods, such as transcatheter arterial infusion (TAI), also play an important role in the treatment of advanced HCC. Although it has been reported that TAI with a high concentration of a fine-powder formulation of cisplatin (DDP-H) reduced intrahepatic recurrence and improved survival, the combined use of TAI with DDP-H and TACE has not yet been investigated...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27880724/hepatic-resection-after-transarterial-chemoembolization-increases-overall-survival-in-large-multifocal-hepatocellular-carcinoma-a-retrospective-cohort-study
#14
Junwei Chen, Lisha Lai, Qu Lin, Wensou Huang, Mingyue Cai, Kangshun Zhu, Mingsheng Huang
To investigate the prognosis of transarterial chemoembolization (TACE) followed by hepatic resection (HR) in large/multifocal hepatocellular carcinoma (HCC), the medical records of consecutive HCC patients who underwent TACE between January 2006 and December 2010 were retrospectively analyzed. Patients who received TACE alone comprised the T group (61 patients), while those who received HR after TACE comprised the T+R group (49 patients). All the resections were successfully performed, and only one class V complication occurred...
November 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27874952/nox1-promotes-colon-cancer-cell-metastasis-via-activation-of-the-adam17-pathway
#15
H-P Wang, X Wang, L-F Gong, W-J Chen, Z Hao, S-W Feng, Y-B Wu, T Ye, Y-K Cai
OBJECTIVE: Reactive oxygen species (ROS) generated by endogenous metabolic enzymes are involved in a variety of pathology processes, including cancer. In particular, superoxide-generating NADPH oxidase 1 (Nox1), a member of Nox enzyme family, is highly expressed in the colon tissue and has been implicated in physiological and pathophysiological states of colon cancer. However, the underlying molecular mechanism of Nox1 in the regulation of colon cancer progression remains largely unknown...
November 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27872985/pharmacokinetics-and-histopathological-findings-of-chemoembolization-using-cisplatin-powder-mixed-with-degradable-starch-microspheres-in-a-rabbit-liver-tumor-model
#16
Takeshi Sato, Toshihiro Tanaka, Hideyuki Nishiofuku, Yasushi Fukuoka, Hiroshi Sakaguchi, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami, Masato Takano, Ichiro Yamato, Masayuki Sho, Chiho Ohbayashi, Toshiko Hirai, Kimihiko Kichikawa
PURPOSE: The purpose of this study is to evaluate the pharmacokinetics and histopathological findings of transarterial chemoembolization (TACE) using cisplatin powder mixed with degradable starch microspheres (DSM) (Cis/DSM-TACE) compared with cisplatin arterial infusion (Cis-AI). MATERIALS AND METHODS: Eighteen rabbits with VX2 liver tumors were divided into two groups: Cis/DSM-TACE (n = 9) and Cis-AI (n = 9) groups. In the Cis/DSM-TACE group, a mixture of cisplatin powder and DSM was injected until stasis of hepatic arterial flow was achieved...
November 21, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/27853648/endothelial-progenitor-cell-number-and-erk-phosphorylation-serve-as-predictive-and-prognostic-biomarkers-in-advanced-hepatocellular-carcinoma-patients-treated-with-sorafenib
#17
Suresh Gopi Kalathil, Amit Anand Lugade, Renuka Iyer, Austin Miller, Yasmin Thanavala
Sorafenib is an oral anti-angiogenic multi-kinase inhibitor used for systemic therapy in patients with advanced hepatocellular carcinoma (HCC) who are not suitable candidates for surgery or liver transplantation. An earlier study conducted with HCC tumor tissue suggested that ERK phosphorylation (pERK), a downstream target of sorafenib, may serve as a potential biomarker for therapeutic efficacy of sorafenib. However, no study thus far has utilized a minimal invasive procedure to predict HCC patient responsiveness to sorafenib...
2016: Oncoimmunology
https://www.readbyqxmd.com/read/27852742/soluble-tnf-regulates-tace-via-ap-2%C3%AE-transcription-factor-in-mouse-dendritic-cells
#18
Lisheng Ge, Nikola L Vujanovic
Dendritic cells (DCs), the essential immunoregulatory and APCs, are major producers of the central mediator of inflammation, soluble TNF-α (sTNF). sTNF is generated by TNF-α converting enzyme (TACE) proteolytic release of the transmembrane TNF (tmTNF) ectodomain. The mechanisms of TACE and sTNF regulation in DCs remain elusive. This study newly defines that sTNF regulates TACE in mouse DCs by engaging the AP-2α transcription factor. We found that the expression of AP-2α was higher, whereas the expression and activity of TACE were lower, in wild-type DCs (wtDCs) than in TNF knockout (TNFko) DCs...
November 16, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27835871/comparing-the-long-term-efficacy-of-standard-and-combined-minimally-invasive-procedures-for-unresectable-hcc-a-mixed-treatment-comparison
#19
Jianghai Zhao, Hui Zhang, Lunshou Wei, Shuping Xie, Zhimin Suo
A small proportion of hepatocellular carcinoma (HCC) patients are suitable for surgical resections and various minimally invasive procedures have been introduced as alternatives to surgical resections. However, the relative efficacy of minimally invasive procedures remains to be studied in the current literature. Several popular minimally invasive procedures (monotherapy or combined therapies) were selected for comparison and their relative long-term efficacy were determined by using the statistics of hazard ratio (HR) which evaluates the survival status of HCC patients in one, two, three and four years, respectively...
November 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27834009/predicting-outcomes-after-chemo-embolization-in-patients-with-advanced-stage-hepatocellular-carcinoma-an-evaluation-of-different-radiologic-response-criteria
#20
Andrew J Gunn, Rahul A Sheth, Brandon Luber, Minh-Huy Huynh, Niranjan R Rachamreddy, Sanjeeva P Kalva
PURPOSE: The purpse of this study was to evaluate the ability of various radiologic response criteria to predict patient outcomes after trans-arterial chemo-embolization with drug-eluting beads (DEB-TACE) in patients with advanced-stage (BCLC C) hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Hospital records from 2005 to 2011 were retrospectively reviewed. Non-infiltrative lesions were measured at baseline and on follow-up scans after DEB-TACE according to various common radiologic response criteria, including guidelines of the World Health Organization (WHO), Response Evaluation Criteria in Solid Tumors (RECIST), the European Association for the Study of the Liver (EASL), and modified RECIST (mRECIST)...
November 10, 2016: Cardiovascular and Interventional Radiology
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