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https://www.readbyqxmd.com/read/28102954/dosimetric-impact-of-lipiodol-in-stereotactic-body-radiation-therapy-on-liver-after-trans-arterial-chemoembolization
#1
Daisuke Kawahara, Shuichi Ozawa, Akito Saito, Teiji Nishio, Tomoki Kimura, Tatsuhiko Suzuki, Kazunari Hioki, Takeo Nakashima, Yoshimi Ohno, Yuji Murakami, Yasushi Nagata
PURPOSE: Stereotactic body radiation therapy (SBRT) combining trans-arterial chemoembolization (TACE) with Lipiodol is expected to improve local control. This study is aimed to estimate the dose enhancement in Lipiodol's proximity and to evaluate the dose calculation accuracy of the Acuros XB (AXB) algorithm and anisotropic analytical algorithm (AAA) in the Eclipse treatment planning system (TPS) (ver. 11, Varian Medical Systems, Palo Alto, USA), compared with that of the Monte Carlo (MC) calculation (using BEAMnrc/DOSXYZnrc code) for a virtual phantom and a treatment plan for liver SBRT after TACE...
January 2017: Medical Physics
https://www.readbyqxmd.com/read/28100632/the-role-of-hepatic-trans-arterial-chemoembolization-in-metastatic-medullary-thyroid-carcinoma-a-specialist-center-experience-and-review-of-the-literature
#2
Simona Grozinsky-Glasberg, Allan Bloom, Naama Lev-Cohain, Alexander Klimov, Hashem Besiso, David Gross
BACKGROUND: Liver metastases are relatively common in patients with metastatic medullary thyroid carcinoma (MTC), carrying a negative impact on disease prognosis. The options for selective therapy of liver metastases in MTC patients are limited to catheter guided procedures such as trans-arterial chemoembolization (TACE). Data regarding the effectiveness and safety of this procedure in MTC is limited. AIM: To explore the clinical outcome, survival and safety profile of TACE for liver metastases in a group of MTC patients...
January 18, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28099930/efficacy-of-transcatheter-arterial-chemoembolization-for-liver-metastases-arising-from-pancreatic-cancer
#3
Jun-Hui Sun, Tan-Yang Zhou, Yue-Lin Zhang, Guan-Hui Zhou, Chun-Hui Nie, Tong-Yin Zhu, Sheng-Qun Chen, Bao-Quan Wang, Song Ye, Yan Shen, Hua Guo, Wei-Lin Wang, Shu-Sen Zheng
PURPOSE: The aim of the study was to evaluate the efficacy of transcatheter arterial chemoembolization (TACE) in treating patients with liver metastases from pancreatic cancer, and explore the prognostic risk factors. RESULTS: Three of the 27 patients were totally recovered, and 12 were partially alleviated. The total efficacy rate was 55.6% (15/27). The median survival time was 13.6 months, and the 0.5-, 1-, 2-, 3-, and 5-year survival rates were 70.4% (19/27), 48...
January 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/28099329/evaluation-of-efficacy-of-transcatheter-arterial-chemoembolization-combined-with-computed-tomography-guided-radiofrequency-ablation-for-hepatocellular-carcinoma-using-magnetic-resonance-diffusion-weighted-imaging-and-computed-tomography-perfusion-imaging-a
#4
Guo-Liang Shao, Jia-Ping Zheng, Li-Wen Guo, Yu-Tang Chen, Hui Zeng, Zheng Yao
BACKGROUND: The purpose of this study is to evaluate the efficacy of transcatheter arterial chemoembolization (TACE) combined with computed tomography-guided radiofrequency ablation (CT-RFA) in the treatment of hepatocellular carcinoma (HCC) using magnetic resonance diffusion weighted imaging (MR-DWI) and CT perfusion imaging (CT-PI). METHODS: From January 2008 to January 2014, a total of 522 HCC patients receiving TACE combined with CT-RFA were included in this study...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28097502/should-we-routinely-use-debtace-for-unresectable-hcc-ctace-versus-debtace-a-single-center-survival-analysis
#5
M Massani, T Stecca, C Ruffolo, N Bassi
Conventional trans-arterial chemoembolization (cTACE) for intermediate stage hepatocellular carcinoma (HCC) achieves a partial response in up to 72% of patients and improves median survival. Drug-eluting-beads-TACE (DEBTACE) improves treatment efficacy and tolerance as compared to cTACE. Our aim was to retrospectively evaluate our experience in the treatment of intermediate/advanced HCC with cTACE versus DEBTACE. Overall survival (OS) was the first endpoint. We retrospectively considered our department register data between 2006 and 2012...
January 17, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28097096/impact-of-different-embolic-agents-for-transarterial-chemoembolization-tace-procedures-on-systemic-vascular-endothelial-growth-factor-vegf-levels
#6
Andreas Schicho, Claus Hellerbrand, Kristina Krüger, Lukas P Beyer, Walter Wohlgemuth, Christoph Niessen, Ernst Hohenstein, Christian Stroszczynski, Philippe L Pereira, Philipp Wiggermann
Background and Aims: Intermediate stage hepatocellular carcinoma (HCC) can be treated by transarterial chemoembolization (TACE). However, there appear to be side effects, such as induction of proangiogenic factors, e.g. vascular endothelial growth factor (VEGF), which have been shown to be associated with a poor prognosis. This prospective study was designed to compare serum VEGF level response after TACE with different embolic agents in patients with HCC. Methods: Patients were assigned to one of three different TACE regimens: degradable starch microspheres (DSM) TACE, drug-eluting bead (DEBDOX) TACE or Lipiodol TACE (cTACE)...
December 28, 2016: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28081589/preemptive-antiviral-therapy-with-entecavir-can-reduce-acute-deterioration-of-hepatic-function-following-transarterial-chemoembolization
#7
Sun Hong Yoo, Jeong Won Jang, Jung Hyun Kwon, Seung Min Jung, Bohyun Jang, Jong Young Choi
BACKGROUND/AIMS: Hepatic damage during transarterial chemoembolization (TACE) is a critical complication in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC). Apart from its role in preventing HBV reactivation, there is some evidence for the benefits of preemptive antiviral therapy in TACE. This study evaluated the effect of preemptive antiviral therapy on acute hepatic deterioration following TACE. METHODS: This retrospective observational study included a prospectively collected cohort of 108 patients with HBV-related HCC who underwent TACE between January 2007 and January 2013...
December 2016: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28078806/prognostic-factors-of-hepatocellular-carcinoma-patients-with-portal-vein-tumor-thrombosis-treated-with-transcatheter-arterial-chemoembolization
#8
Hongyuan Liang, Peng Cui, Qiyong Guo, Xiaonan Mao, Feng Wen, Wei Sun, Ming Shan, Zaiming Lu
AIM: To investigate the factors that influence survival of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombosis (PVTT) following transarterial chemoembolization (TACE). METHODS: Retrospectively enrolled HCC patients with PVTT (n = 57). Patients received TACE, and the local tumor response was evaluated by modified response evaluation criteria in solid tumor (mRECIST). Overall survival and disease progression were evaluated using Kaplan-Meier survival curves...
January 12, 2017: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28076848/endovascular-brachytherapy-combined-with-portal-vein-stenting-and-transarterial-chemoembolization-improves-overall-survival-of-hepatocellular-carcinoma-patients-with-main-portal-vein-tumor-thrombus
#9
Tian-Zhu Yu, Wen Zhang, Qing-Xin Liu, Wen-Hui Li, Jing-Qin Ma, Zi-Han Zhang, Min-Jie Yang, Jian-Hua Wang, Bing Chen, Shao-Chong Zeng, Jian-Jun Luo, Ling-Xiao Liu, Zhi-Ping Yan
Hepatocellular carcinoma (HCC) patients with main portal vein tumor thrombus have a median survival time of only about 4 months. We therefore compared the safety and efficacy of endovascular brachytherapy (EVBT) and sequential three-dimensional conformal radiotherapy (3-DCRT). From a cohort of 176 patients, we treated 123 with EVBT using iodine-125 seed strands (group A) and the remaining 53 with sequential 3-DCRT (group B). Overall survival, progression free survival and stent patency characteristics were compared between the two groups...
January 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28070766/radiofrequency-ablation-combined-with-transarterial-chemoembolization-versus-hepatectomy-for-patients-with-hepatocellular-carcinoma-within-milan-criteria-a-retrospective-case-control-study
#10
A K Bholee, K Peng, Z Zhou, J Chen, L Xu, Y Zhang, M Chen
PROPOSAL: To compare the effectiveness of TACE + RFA with hepatectomy in patients with HCC within Milan criteria. METHODS: It is a retrospective matched case-control study from January 2006 to December 2010 in a tertiary cancer center. 74 patients with HCC within Milan criteria initially treated with TACE + RFA were identified and compared with 148 matched controls selected from a pool of 782 patients who received hepatectomy. Patients were matched with respect to age, gender, tumor size and number, AFP and liver function test...
January 9, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28070164/the-negative-effect-of-preoperative-transcatheter-arterial-chemoembolization-on-long-term-outcomes-for-resectable-hepatocellular-carcinoma-a-propensity-score-matching-analysis
#11
Masataka Amisaki, Soichiro Honjo, Masaki Morimito, Takehiko Hanaki, Yosuke Arai, Naruo Tokuyasu, Teruhisa Sakamoto, Yasufumi Ohuchi, Hiroaki Saito
BACKGROUND: Preoperative transcatheter arterial chemoembolization (TACE) is administered to improve long-term outcome after surgical resection of hepatocellular carcinoma (HCC). However, the survival benefit of preoperative TACE is controversial. We conducted a retrospective case-control study to evaluate the effect of preoperative TACE on prognosis. METHODS: A total of 121 patients who underwent curative resection of HCC were divided into two groups according to whether they received preoperative TACE...
December 2016: Yonago Acta Medica
https://www.readbyqxmd.com/read/28069044/effect-of-transcutaneous-electrical-acupoint-stimulation-combined-with-palonosetron-on-chemotherapy-induced-nausea-and-vomiting-a-single-blind-randomized-controlled-trial
#12
Jing Xie, Lei-Hua Chen, Zhou-Yu Ning, Chen-Yue Zhang, Hao Chen, Zhen Chen, Zhi-Qiang Meng, Xiao-Yan Zhu
BACKGROUND: Chemotherapy-induced nausea and vomiting adversely affects the quality of life of patients who receive chemotherapy via intravenous infusion or transcatheter arterial chemoembolization (TACE). This study aimed to investigate the clinical effects of transcutaneous electrical acupoint stimulation (TEAS) on nausea and vomiting after TACE. METHODS: A total of 142 patients who received TACE with cisplatin for primary or metastatic liver cancer were assigned to the active-acupuncture (n = 72) or placebo-acupuncture (n = 70) groups using a covariate-adaptive randomization at a ratio of 1:1...
January 10, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28056193/reduced-cd62l-expression-on-t-cells-and-increased-soluble-cd62l-levels-predict-molecular-response-to-tyrosine-kinase-inhibitor-therapy-in-early-chronic-phase-chronic-myelogenous-leukemia
#13
Sieghart Sopper, Satu Mustjoki, Deborah White, Timothy Hughes, Peter Valent, Andreas Burchert, Bjørn T Gjertsen, Günther Gastl, Matthias Baldauf, Zlatko Trajanoski, Frank Giles, Andreas Hochhaus, Thomas Ernst, Thomas Schenk, Jeroen J W M Janssen, Gert J Ossenkoppele, Kimmo Porkka, Dominik Wolf
Purpose Immunologic surveillance of minimal residual disease in chronic myelogenous leukemia (CML) may be relevant for long-term control or cure of CML. Little is known about immune-modulatory effects of nilotinib in vivo, potentially predicting response to therapy. Patients and Methods A prospective and comprehensive flow cytometry-based immunomonitoring program paralleled the ENEST1st clinical study, investigating 52 nilotinib-naïve patients with chronic-phase CML. Data were verified in independent validation cohorts...
January 10, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28053537/comparison-of-intra-arterial-chemoembolization-with-and-without-radiotherapy-for-advanced-hepatocellular-carcinoma-with-portal-vein-tumor-thrombosis-a-meta-analysis
#14
Qianqian Zhao, Kunli Zhu, Jinbo Yue, Zhonghua Qi, Shumei Jiang, Xiaoqing Xu, Rui Feng, Renben Wang
PURPOSE: Numerous studies have tried to combine transarterial chemoembolization (TACE) or hepatic arterial infusion chemotherapy (HAIC) with radiotherapy (RT) for the treatment of hepatocellular carcinoma (HCC) patients with portal vein tumor thrombus (PVTT). However, the efficacy of TACE or HAIC combined with RT versus TACE or HAIC alone remains controversial. Thus, we performed a meta-analysis to compare the efficacy and safety of intra-arterial chemoembolization combined with RT versus intra-arterial chemoembolization alone for the treatment of HCC patients with PVTT...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28052301/c-arm-cone-beam-computed-tomography-guidance-for-radiofrequency-ablation-in-hepatocellular-carcinoma
#15
Keizo Kato, Hiroshi Abe, Makiko Ika, Takeshi Yonezawa, Yoshiyuki Sato, Noriko Hanawa, Shohei Shimizu, Shinji Endo, Ryota Matsuo, Akihito Tsubota
OBJECTIVE: To assess the usefulness of C-arm cone beam computed tomography (CBCT) combined with ultrasound for the treatment of hepatocellular carcinoma (HCC) by radiofrequency ablation (RFA). METHODS: Patients underwent RFA following transcatheter arterial chemoembolization (TACE) or RFA alone under ultrasound or CBCT guidance combined with ultrasound-based techniques. They were divided into 2 groups based on the use (C group) and nonuse (NC group) of CBCT guidance...
January 5, 2017: Oncology
https://www.readbyqxmd.com/read/28048039/su-f-i-74-dose-evaluation-based-on-monte-carlo-simulation-of-three-dimensional-rotational-angiography-during-hepatic-transarterial-chemoembolization-procedures
#16
Y Hwang, K Lui, Y Lin, H Tsai
PURPOSE: This study was aimed to investigate the dose with patient performing three-dimensional (3D) angiography imaging during hepatic transarterial chemoembolization (TACE) procedures. METHODS: Organ doses and effective doses calculations were retrospectively performed in 88 patients (61 males and 27 females with averaged age of 65.4±12.6 years old) referred for hepatic TACE on a digital flat-panel angiography system (Bransist safire; Shimadzu) using software (PCXMC; Helsinki, Finland) based on Monte Carlo technique...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046479/we-ab-bra-05-pet-guided-delivery-quality-evaluation-of-yttrium-90-microsphere-radioembolizaton-for-hepatocellular-carcinoma-patients-the-optimal-sequence-of-radioembolizaton-and-chemoembolization-treatments
#17
M Lin, B Saboury
PURPOSE: Selective-internal-radiation-therapy (SIRT) and transarterial-chemoembolization (TACE) are commonly used for treatment of liver tumors. The use of TACE, which is macroembolic, prior to SIRT may cause hemodynamic changes in tumor vasculature that impair yttrium-90 (90Y) microsphere delivery to the targeted lesions. This work aims to quantify dosimetric tumor coverage using 90Y positron emission tomography (PET) dosimetry after SIRT alone compared to TACE followed by SIRT. METHODS: A total of 40 consecutive hepatocellular carcinoma (HCC) SIRT patients who had a post-SIRT 90Y PET/CT scan were evaluated...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28036272/chemoembolization-of-liver-cancer-with-drug-loading-microsphere-50-100%C3%AE-m
#18
Jun-Hui Sun, Guan-Hui Zhou, Yue-Lin Zhang, Chun-Hui Nie, Tan-Yang Zhou, Jing Ai, Tong-Yin Zhu, Wei-Lin Wang, Shu-Sen Zheng
Transcatheter arterial chemoembolization (TACE) is the mainstay of treatment for unresectable hepatocellular carcinoma (HCC). The efficacy of conventional TACE (cTACE) in liver metastases is not satisfactory, which might be due to the fact of embolic material used. Recently, as a new type of drug-loading microsphere, HepaSphere has been introduced in China. In this study, there were total 30 patients (18 males and 12 females) with liver cancer underwent embolization with Hepasphere microsphere. And a total of 44 TACE procedures were performed using 50-100μm HepaSphere...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28035432/chemoembolization-of-neuroendocrine-liver-metastases-using-streptozocin-and-tris-acryl-microspheres-embozar-embosphere%C3%A2-%C3%A2-zanosar-study
#19
Jean-Pierre Pelage, Audrey Fohlen, Emmanuel Mitry, Christine Lagrange, Alain Beauchet, Philippe Rougier
PURPOSE: The purpose of this prospective observational study was to evaluate the efficacy and tolerability of transarterial chemoembolization (TACE) for neuroendocrine liver metastases using a combination of streptozocin, Lipiodol, and tris-acryl microspheres. PATIENTS AND METHODS: A total of 16 men and 9 women aged 59.6 ± 11.3 years, all with predominant liver disease, underwent 54 courses of TACE using an emulsion of 1.5 g of streptozocin and 10 ml of Lipiodol...
December 29, 2016: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28033293/transarterial-embolization-chemoembolization-therapy-for-hepatocellular-carcinoma-fed-by-adrenal-artery-preliminary-results
#20
Shibing Hu, Jianfei Tu, Zhongzhi Jia, Yuanquan Huang, Guomin Jiang
To assess the value of transarterial embolization/chemoembolization (TAE/TACE) therapy via adrenal artery for patients with hepatocellular carcinoma (HCC). Patients with HCC who underwent TAE/TACE therapy via adrenal artery between May 2003 and October 2015 across 4 medical centers were identified. Clinical information, procedural data, and imaging data were analyzed to assess technical success, disease control, and survival rates. A t test was used to compare the differences in serum alpha-fetoprotein before and after treatment...
December 2016: Medicine (Baltimore)
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