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JOURNAL ARTICLE
C E Hilberdink, M van Zuiden, M Olff, T J Roseboom, S R de Rooij
People commonly face adverse circumstances throughout life, which increases risk for psychiatric disorders, such as anxiety, depression, psychosis, and posttraumatic stress disorder (PTSD). Adversities may occur during different periods in life. Especially adversity during early periods has been suggested to put individuals at risk for adverse mental health outcomes. Here, we investigated whether timing of adversity during the prenatal period, childhood, or mid-to-late adulthood differentially impacted classification into late adulthood symptom profiles...
July 21, 2023: Journal of Developmental Origins of Health and Disease
#22
JOURNAL ARTICLE
Ahmad Pour-Rashidi, Mohamad Namvar, Arad Iranmehr, Allegra Carpaneto, Sara Hanaei, Nima Rezaei
Central nervous system (CNS) tumors are mainly diagnosed by physical symptoms such as paralysis, visual field defect, seizure, and loss of consciousness. The psychological and psychiatric background of CNS tumors, whether in preoperative or postoperative period, has long been a neglected topic; however, lately, many authors and researchers have paid more attention to these manifestations. Neurocognition is a subset of parameters, including attention, memory, mood, emotions, language production, personality, executive function, problem-solving, calculation, and spatial cognition, making up the patient's cognitive performance...
2023: Advances in Experimental Medicine and Biology
#23
JOURNAL ARTICLE
Rafae A Wathra, Xiaoyu Men, Samar S M Elsheikh, Victoria S Marshe, Tarek K Rajji, Jennifer I Lissemore, Benoit H Mulsant, Jordan F Karp, Charles F Reynolds, Eric J Lenze, Zafiris J Daskalakis, Daniel J Müller, Daniel M Blumberger
Late-life depression (LLD) is a heterogenous mood disorder influenced by genetic factors. Cortical physiological processes such as cortical inhibition, facilitation, and plasticity may be markers of illness that are more strongly associated with genetic factors than the clinical phenotype. Thus, exploring the relationship between genetic factors and these physiological processes may help to characterize the biological mechanisms underlying LLD and improve diagnosis and treatment selection. Transcranial magnetic stimulation (TMS) combined with electromyography was used to measure short interval intracortical inhibition (SICI), cortical silent period (CSP), intracortical facilitation (ICF), and paired associative stimulation (PAS) in 79 participants with LLD...
June 30, 2023: Translational Psychiatry
#24
RANDOMIZED CONTROLLED TRIAL
Chirag M Vyas, David Mischoulon, Grace Chang, Nancy R Cook, Alison Weinberg, Trisha Copeland, Jae H Kang, Vadim Bubes, Georgina Friedenberg, Meryl S LeBoff, I-Min Lee, Julie E Buring, JoAnn E Manson, Charles F Reynolds, Olivia I Okereke
Objective: To test vitamin D3 and omega-3 fatty acids (omega-3s) for late-life depression prevention under the National Academy of Medicine framework for indicated (targeting subthreshold depression) and selective (targeting presence of high-risk factors) prevention. Methods: The VITamin D and OmegA-3 TriaL (VITAL) is a 2 × 2 factorial trial of vitamin D3 (2,000 IU/d) and/or omega-3s (1 g/d) for cardiovascular and cancer prevention (enrollment: November 2011-March 2014; end date: December 31, 2017)...
June 26, 2023: Journal of Clinical Psychiatry
#25
Anna K McKenzie, Rishab Chawla, Bhargav Patel, Reddy B Shashank
Bipolar I disorder is characterized by the presence of at least one manic episode (DSM-5). Despite a decent percentage of individuals being diagnosed later in life, there currently exist no formal treatment guidelines for late-onset bipolar disorder (LOBD), which remains poorly understood. Typically, manic or manic-like episodes in elderly individuals can be thought of as arising from a secondary, physical cause. However, in the absence of a pre-existing neurological disorder - and when laboratory, imaging, and exam findings do not fully support a neurological picture - the determination of a structural versus primary etiology for LOBD becomes challenging...
May 2023: Curēus
#26
JOURNAL ARTICLE
Maria Elena Bacchin, Giovanna Vitaliti, Cristina Malaventura, Silvia Meggiolaro, Vincenzo Zanardo, Elisa Ballardini, Elisa Cainelli, Agnese Suppiej
BACKGROUND: Psychopathology has not yet been studied beyond pediatric age for all degrees of prematurity, including late-preterm, particularly in those who grew up with no apparent neurodevelopmental sequelae. This study aimed to examine psychopathological outcome following preterm birth and admission to neonatal intensive care in young adults without major neurodevelopmental and psychopathological problems that emerged during childhood. METHODS: An Italian single-center prospective cohort study...
June 8, 2023: European Journal of Paediatric Neurology: EJPN
#27
JOURNAL ARTICLE
Karen L Fortuna, Rebecca Heller, Hannah Crowe-Cumella, Andrew Bohm
OBJECTIVE: This study aimed to estimate gaps in supportive housing services for racially and ethnically diverse older adults with SMI residing in supportive housing. METHODS: This study had a total of 753 respondents split into two diagnostic groups, the Delusional and Psychotic Disorders Group, and the Mood (Affective) Disorder Group. Demographic and primary ICD diagnosis data (F2x and F3x) were extracted from medical records. Three elements were measured: supportive housing service needs, fall prevention, and activities in daily living and instrumental activities in daily living...
April 19, 2023: American Journal of Geriatric Psychiatry
#28
JOURNAL ARTICLE
Mafalda Simões Cunha, Rita Amaral, Ana Margarida Pereira, Rute Almeida, Magna Alves-Correia, Cláudia Chaves Loureiro, Cristina Lopes, Joana Carvalho, Carmelita Ribeiro, Carmen Vidal, Dario Antolín-Amérigo, Diana Pinto, Manuel Ferreira-Magalhães, Maria João Vasconcelos, Carlos Lozoya, Natacha Santos, Francisca Cardia, Luís Taborda-Barata, Rosário Ferreira, Pedro Morais Silva, Tania Monteiro Ferreira, Raquel Câmara, Eurico Silva, Diana Bordalo, Cristina Guimarães, Maria José Calix, Sofia da Silva, Maria Luís Marques, Ana Morete, Carlos Nunes, Cláudia Vieira, Rosália Páscoa, Adelaide Alves, José Varanda Marques, Bruno Reis, Luís Monteiro, Rosário Monteiro, Margarida Cepa, Bruno Valentim, Daniela Sousa Coelho, Sara Fernandes, Patrícia Meireles, Margarida Abreu Aguiar, Ana Rita Mourão, Joao A Fonseca, Cristina Jácome
OBJECTIVES: Anxiety and depression are relevant comorbidities in asthma, but, in Portugal and Spain, data on this topic are scarce. We assessed, in patients with asthma, the frequency of anxiety and depression using the Hospital Anxiety and Depression Scale (HADS) and the European Quality of Life Five Dimension Questionnaire (EQ-5D); the level of agreement between these questionnaires, and the factors associated with these symptoms. METHODS: This is a secondary analysis of the INSPIRERS studies...
May 5, 2023: BMJ Open
#29
REVIEW
Kurt A Jellinger
Depression is frequent in older individuals and is often associated with cognitive impairment and increasing risk of subsequent dementia. Late-life depression (LLD) has a negative impact on quality of life, yet the underlying pathobiology is still poorly understood. It is characterized by considerable heterogeneity in clinical manifestation, genetics, brain morphology, and function. Although its diagnosis is based on standard criteria, due to overlap with other age-related pathologies, the relationship between depression and dementia and the relevant structural and functional cerebral lesions are still controversial...
August 2023: Journal of Neural Transmission
#30
JOURNAL ARTICLE
Aswin Ratheesh, Dylan Hammond, Caroline Gao, Steven Marwaha, Andrew Thompson, Jessica Hartmann, Christopher Davey, Stanley Zammit, Michael Berk, Patrick McGorry, Barnaby Nelson
Staging models with transdiagnostic validity across mood, psychotic, and anxiety disorders could advance early intervention efforts as well as our understanding of the common underpinnings of such psychopathology. However, there are few well-supported operationalisations for such transdiagnostic models, particularly in community-based samples. We aimed to explore the inter-relationships among mood, psychotic, and anxiety symptom stages, and their common risk factors to develop data-informed transdiagnostic stages...
March 29, 2023: Translational Psychiatry
#31
JOURNAL ARTICLE
Margot J Wagenmakers, Mardien L Oudega, Federica Klaus, David Wing, Gwendolyn Orav, Laura K M Han, Julia Binnewies, Aartjan T F Beekman, Dick J Veltman, Didi Rhebergen, Eric van Exel, Lisa T Eyler, Annemieke Dols
BACKGROUND: Severe depression is associated with accelerated brain aging. BrainAge gap, the difference between predicted and observed BrainAge, was investigated in patients with late-life depression (LLD). We aimed to examine BrainAge gap in LLD and its associations with clinical characteristics indexing LLD chronicity, current severity, prior to electroconvulsive therapy (ECT) and ECT outcome. METHODS: Data was analyzed from the Mood Disorders in Elderly treated with Electroconvulsive Therapy (MODECT) study...
June 1, 2023: Journal of Affective Disorders
#32
REVIEW
Victor Ruggieri
Autism is a neurodevelopmental disorder characterized by a qualitative alteration in social interaction and communication, associated with restricted interests and stereotyped behaviors. It can be associated with medical problems such as epilepsy, gastrointestinal dysfunction, sleep disorders, other neurodevelopmental disorders such as language impairment, intellectual disability, sensory dysfunction, ADH/D, motor clumsiness, and/or neuropsychiatric disorders such as anxiety, depression, catatonia, schizophrenia, obsessive-compulsive disorders, behavioral and impulsive disorders, among others...
March 2023: Medicina
#33
JOURNAL ARTICLE
Ilex Beltran-Najera, Andrea Mustafa, Desmond Warren, Zach Salling, Maria Misiura, Steven Paul Woods, Vonetta M Dotson
Depression and cardiovascular disease are common and associated with one another in HIV disease. This study aimed to determine the frequency and everyday functioning implications of the clinical syndrome of vascular depression among people living with HIV (PLWH). Participants in this cross-sectional study included 536 PLWH and 272 seronegative individuals who completed a biomedical and psychiatric research evaluation. Vascular depression was operationalized as the current presence of: 1) two or more vascular conditions; and 2) depression as determined by a normative elevation on the Depression/Dejection subscale of the Profile of Mood States or a diagnosis of Major Depressive Disorder per the Composite International Diagnostic Interview...
February 6, 2023: Journal of Psychiatric Research
#34
JOURNAL ARTICLE
Helle B Krogh, Maj Vinberg, Gitte Lee Mortensen, Ditte Skakke, Dorthe Nielsen, Annamaria Giraldi
BACKGROUND: Individuals with mental health disorders have a higher risk of sexual problems impacting intimate relations and quality of life. For individuals with bipolar disorder (BD) the mood shifts might to a particular degree affect their sexual function with possible hypersexual interest during manic episodes and low sexual interest during depressive episodes. The diagnosis is often given in late adolescence, which may impact sexual identity and development. Only a few studies have looked at BD and sexual life, with no qualitative research on the topic...
February 3, 2023: International Journal of Bipolar Disorders
#35
REVIEW
Meysam Amidfar, Michelle Lima Garcez, Yong-Ku Kim
An association with circadian clock function and pathophysiology of aging, major depressive disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed as a factor in the development of these diseases. Depression and changes in circadian rhythm have been increasingly suggested as the two primary overlapping and interpenetrating changes that occur with aging. The relationship between AD and depression in late life is not completely understood and probably is complex. Patients with major depression or AD suffer from disturbed sleep/wake cycles and altered rhythms in daily activities...
April 20, 2023: Progress in Neuro-psychopharmacology & Biological Psychiatry
#36
REVIEW
Carla Piel, Arnim Quante
BACKGROUND: Depression in the elderly requires different treatment options because therapies that are commonly used for depression in younger patients show different effects later in life. Treatment options for late-life depression (LLD) are summarized in this article. METHODS: A literature search in Medline/PubMed performed in June 2020 identified 83 relevant studies. RESULTS: Pharmacotherapy with selective serotonin reuptake inhibitors can be an effective first-line treatment in LLD, but >50% of elderly patients do not adequately respond...
January 1, 2023: Journal of Psychiatric Practice
#37
REVIEW
Maria Devita, Rossella De Salvo, Adele Ravelli, Marina De Rui, Alessandra Coin, Giuseppe Sergi, Daniela Mapelli
Depression is one of the most common mood disorders in the late-life population and is associated with poor quality of life and increased morbidity, disability and mortality. Nevertheless, in older adults, it often remains undetected and untreated. This narrative review aims at giving an overview on the main definitions, clinical manifestations, risk and protective factors for depression in the elderly, and at discussing the main reasons for its under/misdiagnosis, such as cognitive decline and their overlapping symptomatology...
2022: Neuropsychiatric Disease and Treatment
#38
JOURNAL ARTICLE
Ryan Ahmed, Brian D Boyd, Damian Elson, Kimberly Albert, Patrick Begnoche, Hakmook Kang, Bennett A Landman, Sarah M Szymkowicz, Patricia Andrews, Jennifer Vega, Warren D Taylor
BACKGROUND: Late-life depression (LLD) is characterized by differences in resting state functional connectivity within and between intrinsic functional networks. This study examined whether clinical improvement to antidepressant medications is associated with pre-randomization functional connectivity in intrinsic brain networks. METHODS: Participants were 95 elders aged 60 years or older with major depressive disorder. After clinical assessments and baseline MRI, participants were randomized to escitalopram or placebo with a two-to-one allocation for 8 weeks...
December 9, 2022: Psychological Medicine
#39
JOURNAL ARTICLE
Haipeng Cai, Ruonan Du, Kebing Yang, Wei Li, Zhiren Wang
BACKGROUND: Depressive disorder is a chronic mental illness that is vulnerable to relapse, imposes a huge economic burden on society and patients, and is a major global public health problem. Depressive disorders are characterized by depressed mood, decreased energy and interest, and suicidal ideation and behavior in severe cases. They can be treated through pharmacotherapy and psychotherapy or physical treatments such as electroconvulsive therapy (ECT). In patients with suicidal ideation, behavior, or refractory depressive disorder ECT has a faster onset of action and better efficacy than pharmacotherapy...
2022: Frontiers in Human Neuroscience
#40
JOURNAL ARTICLE
Anna Plachti, William F C Baaré, Louise Baruël Johansen, Wesley K Thompson, Hartwig R Siebner, Kathrine Skak Madsen
Adolescence is characterized by significant brain development and marks a period of the life span with an increased incidence of mood disorders, especially in females. The risk of developing mood disorders is also higher in individuals scoring high on neuroticism, a personality trait characterized by a tendency to experience negative and anxious emotions. We previously found in a cross-sectional study that neuroticism is associated with microstructural left-right asymmetry of the fronto-limbic white matter involved in emotional processing, with opposite effects in female and male adolescents...
November 25, 2022: Human Brain Mapping
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