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Late life mood disorders

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https://www.readbyqxmd.com/read/28365469/the-impact-of-frailty-on-depressive-disorder-in-later-life-findings-from-the-netherlands-study-of-depression-in-older-persons
#1
R M Collard, M H L Arts, A H Schene, P Naarding, R C Oude Voshaar, H C Comijs
BACKGROUND: Physical frailty and depressive symptoms are reciprocally related in community-based studies, but its prognostic impact on depressive disorder remains unknown. METHODS: A cohort of 378 older persons (≥60 years) suffering from a depressive disorder (DSM-IV criteria) was reassessed at two-year follow-up. Depressive symptom severity was assessed every six months with the Inventory of Depressive Symptomatology, including a mood, motivational, and somatic subscale...
January 24, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28331326/lithium-in-late-life-mania-a-systematic-review
#2
REVIEW
Pasquale De Fazio, Raffaele Gaetano, Mariarita Caroleo, Maria Pavia, Giovanbattista De Sarro, Andrea Fagiolini, Cristina Segura-Garcia
The prevalence of mania among >65-year-olds ranges from 0.1% to 0.4% and its treatment is a particular challenge for clinicians. Although lithium is the treatment of choice for bipolar disorder (BD), its use in elderly population was recently questioned. This study provides a comprehensive review of literature on the efficacy and tolerability of lithium as a pharmacologic treatment for mania in elderly BD patients. We conducted a systematic review, based on PRISMA guidelines, of articles published between 1970 and August 2016 and indexed in the following databases: EMBASE, MEDLINE, Cochrane Library Databases and PsycINFO...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28306157/psychiatric-diagnoses-among-older-recipients-of-publicly-funded-mental-health-services
#3
Sarah T Stahl, Charles F Reynolds, Ellen M Whyte, Steven M Albert
OBJECTIVES: To compare the prevalence of psychiatric diagnoses among older recipients of publicly funded mental health services (county safety-net base services and Medicaid) to psychiatric diagnoses in an insured population of older adults from the same county. DESIGN: Secondary analysis of county human services claims data and claims from an insured population in the same county. SETTING: Inpatient and outpatient clinics in Allegheny County, PA...
March 17, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28161971/assessment-of-implicit-self-esteem-in-older-adults
#4
Ineke Demeyer, Nuria Romero, Rudi De Raedt
The interplay between actual and ideal self-esteem may be a key component in emotional disorders. Since automatic self-evaluations are not always consciously accessible, assessment through implicit measures is necessary. Given the lack of implicit self-esteem measures in late life, we aimed to identify a reliable measure and to clarify the role of actual and ideal self-esteem in mood and depressive symptoms in older adults. Forty-nine older adults completed two adapted Go/No go Association tasks measuring implicit actual and ideal self-esteem and measures of mood and depressive symptoms...
February 1, 2017: Assessment
https://www.readbyqxmd.com/read/28138119/the-normalization-of-brain-%C3%A2-%C3%A2-f-fluorodeoxy-d-glucose-positron-emission-tomography-hypometabolism-following-electroconvulsive-therapy-in-a-55-year-old-woman-with-treatment-resistant-late-onset-depression-a-case-report
#5
Jeongjae Bak, Sang Mi Lee, Young-Joon Kwon, Se-Hoon Shim, Joong Il Kim
Major depressive disorder, especially in later life, has heterogeneous clinical characteristics and treatment responses. Symptomatically, psychomotor retardation, lack of energy, and apathy tends to be more common in people with late-onset depression (LOD). Despite recent advances in psychopharmacologic treatments, 20% to 30% of patients with mood disorders experience inadequate responses to medication, often resulting in a trial of electroconvulsive therapy (ECT). However, the therapeutic mechanism of ECT is still unclear...
February 28, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27994004/biological-aging-and-the-future-of-geriatric-psychiatry
#6
Bret R Rutherford, Warren D Taylor, Patrick J Brown, Joel R Sneed, Steven P Roose
Advances in understanding the biological bases of aging have intellectually revitalized the field of geriatric psychiatry and broadened its scope to include promoting successful aging and studying resilience factors in older adults. To describe the process by which this paradigm shift has occurred and illustrate its implications for treatment and research of late-life brain disorders, late-life depression is discussed as a prototype case. Prior phases of geriatric psychiatry research were focused on achieving depressive symptom relief, outlining pharmacokinetic and pharmacodynamic differences between older and younger adults, and identifying moderators of treatment response...
March 1, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/27825555/neuroticism-traits-selectively-impact-long-term-illness-course-and-cognitive-decline-in-late-life-depression
#7
Kevin J Manning, Grace Chan, David C Steffens
OBJECTIVES: Neuroticism is a broad construct that conveys a predisposition to experience psychological distress and negative mood states. Vulnerability to stress (VS) is one neuroticism trait that has been linked to worse mood and cognitive outcomes in older adults. We hypothesized that elevated VS would be associated with worse illness course and cognitive decline in older adults with late-life major depression (LLD). DESIGN: Participants were enrolled in the Neurocognitive Outcomes of Depression in the Elderly (NCODE), a longitudinal investigation of the predictors of poor illness course and cognitive decline in LLD...
March 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27806704/vascular-depression-consensus-report-a-critical-update
#8
EDITORIAL
Howard J Aizenstein, Andrius Baskys, Maura Boldrini, Meryl A Butters, Breno S Diniz, Manoj Kumar Jaiswal, Kurt A Jellinger, Lev S Kruglov, Ivan A Meshandin, Milija D Mijajlovic, Guenter Niklewski, Sarah Pospos, Keerthy Raju, Kneginja Richter, David C Steffens, Warren D Taylor, Oren Tene
BACKGROUND: Vascular depression is regarded as a subtype of late-life depression characterized by a distinct clinical presentation and an association with cerebrovascular damage. Although the term is commonly used in research settings, widely accepted diagnostic criteria are lacking and vascular depression is absent from formal psychiatric manuals such as the Diagnostic and Statistical Manual of Mental Disorders, 5(th) edition - a fact that limits its use in clinical settings. Magnetic resonance imaging (MRI) techniques, showing a variety of cerebrovascular lesions, including extensive white matter hyperintensities, subcortical microvascular lesions, lacunes, and microinfarcts, in patients with late life depression, led to the introduction of the term "MRI-defined vascular depression"...
November 3, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27771245/early-and-late-onset-depression-in-late-life-a-prospective-study-on-clinical-and-structural-brain-characteristics-and-response-to-electroconvulsive-therapy
#9
Annemiek Dols, Filip Bouckaert, Pascal Sienaert, Didi Rhebergen, Kristof Vansteelandt, Mara Ten Kate, Francois-Laurent de Winter, Hannie C Comijs, Louise Emsell, Mardien L Oudega, Eric van Exel, Sigfried Schouws, Jasmien Obbels, Mike Wattjes, Frederik Barkhof, Piet Eikelenboom, Mathieu Vandenbulcke, Max L Stek
OBJECTIVE: The clinical profile of late-life depression (LLD) is frequently associated with cognitive impairment, aging-related brain changes, and somatic comorbidity. This two-site naturalistic longitudinal study aimed to explore differences in clinical and brain characteristics and response to electroconvulsive therapy (ECT) in early- (EOD) versus late-onset (LOD) late-life depression (respectively onset <55 and ≥55 years). METHODS: Between January 2011 and December 2013, 110 patients aged 55 years and older with ECT-treated unipolar depression were included in The Mood Disorders in Elderly treated with ECT study...
February 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27660450/late-life-bipolar-disorder-evolving-into-frontotemporal-dementia-mimic
#10
Annemiek Dols, Welmoed Krudop, Christiane Möller, Kenneth Shulman, Martha Sajatovic, Yolande Al Pijnenburg
OBJECTIVES: Although bipolar disorder has been understood classically as a cyclic disease with full recovery between mood episodes, in the last decade, evidence has accumulated supporting progressive features. The clinical picture of advanced or end-stage bipolar disorder is heterogeneous with possible deficits in cognition and behavior, as illustrated by our case series. CASES: From our neuropsychiatric outpatient clinic, we describe four cases with bipolar disorder gradually developing a clinical syndrome, including apathy, disinhibition, loss of empathy, stereotypical behavior, and compulsiveness, fulfilling the criteria for possible behavioral variant frontotemporal dementia...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27634147/post-retrieval-extinction-in-adolescence-prevents-return-of-juvenile-fear
#11
Carolyn E Jones, Marie-H Monfils
Traumatic experiences early in life can contribute to the development of mood and anxiety disorders that manifest during adolescence and young adulthood. In young rats exposed to acute fear or stress, alterations in neural development can lead to enduring behavioral abnormalities. Here, we used a modified extinction intervention (retrieval+extinction) during late adolescence (post-natal day 45 [p45]), in rats, to target auditory Pavlovian fear associations acquired as juveniles (p17 and p25). The effects of adolescent intervention were examined by assessing freezing as adults during both fear reacquisition and social transmission of fear from a cagemate...
October 2016: Learning & Memory
https://www.readbyqxmd.com/read/27601905/mood-disorders-in-the-elderly-prevalence-functional-impact-and-management-challenges
#12
REVIEW
Leandro da Costa Lane Valiengo, Florindo Stella, Orestes Vicente Forlenza
Despite the lower prevalence of severe mood disorders in the elderly as compared to younger adults, late-life depression and bipolar disorder (BD) are more strongly associated with negative outcomes related to the presence of medical comorbidities, cognitive deficits, and increased suicide risk and overall mortality. The mechanisms that contribute to these associations are probably multifactorial, involving pathological factors related directly and indirectly to the disease itself, ranging from biological to psychosocial factors...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27456243/the-endocannabinoid-system-and-post-traumatic-stress-disorder-ptsd-from-preclinical-findings-to-innovative-therapeutic-approaches-in-clinical-settings
#13
Andrea Berardi, Gustav Schelling, Patrizia Campolongo
Post-Traumatic Stress Disorder (PTSD) is a psychiatric chronic disease developing in individuals after the experience of an intense and life-threatening traumatic event. The post-traumatic symptomatology encompasses alterations in memory processes, mood, anxiety and arousal. There is now consensus in considering the disease as an aberrant adaptation to traumatic stress. Pharmacological research, aimed at the discovery of new potential effective treatments, has lately directed its attention towards the "so-called" cognitive enhancers...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27442457/screening-for-bipolar-disorders-a-public-health-issue
#14
REVIEW
M G Carta, J Angst
INTRODUCTION: Bipolar disorder (BD) is a public health issue; it is one of the leading causes of disability and its late diagnosis heightens the impact of the condition. Screening tools for early detection could be extremely useful. METHODS: Narrative review on screening of BD. RESULTS: Screening questionnaires have high sensitivity but relatively low specificity if DSM diagnoses are taken as the "gold standard". Critics maintain that an excess of false positives makes such tools unnecessary for identifying cases and of little use in screening studies consisting of two phases...
November 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27262639/retrospective-age-of-onset-and-projected-lifetime-prevalence-of-psychiatric-disorders-among-u-s-army-national-guard-soldiers
#15
David S Fink, Joseph R Calabrese, Israel Liberzon, Marijo B Tamburrino, Philip Chan, Greg H Cohen, Laura Sampson, Philip L Reed, Edwin Shirley, Toyomi Goto, Nicole D'Arcangelo, Thomas Fine, Sandro Galea
BACKGROUND: The study of military-related mental health has been disproportionately focused on current symptomology rather than potentially more informative life course mental health. Indeed, no study has assessed age-of-onset and projected lifetime prevalence of disorders among reservists. METHODS: Age-of-onset and projected lifetime DSM-IV anxiety, mood, and substance use disorders were assessed in 671 Ohio Army National Guard soldiers aged 17-60 years. Between 2008 and 2012, face-to-face clinical assessments and surveys were conducted using the Structured Clinical Interview for DSM-IV and Clinician-Administered PTSD Scale...
September 15, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27231841/prediction-of-late-onset-psychiatric-disorder-in-survivors-of-severe-injury-findings-of-a-latent-transition-analysis
#16
David Forbes, Nathan Alkemade, Angela Nickerson, Richard A Bryant, Mark Creamer, Derrick Silove, Alexander C McFarlane, Miranda Van Hoof, Andrea J Phelps, Susan Rees, Zachary Steele, Meaghan O'Donnell
OBJECTIVE: There is a growing body of evidence indicating that late or delayed onset of psychiatric disorder following traumatic injury and other psychological trauma is common. This research, however, has not examined factors that pose risks for delayed development of different types of psychopathology or at different time points. Such research has considerable implications for the development of screening, assessment, and intervention practices. This article investigates risk factors for late-onset disorders up to 72 months after a severe injury...
June 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27152905/alterations-in-event-related-potential-responses-to-empathy-for-pain-in-schizophrenia
#17
Cristina Gonzalez-Liencres, Elliot C Brown, Cumhur Tas, Anja Breidenstein, Martin Brüne
Lack of empathy is a critical factor impacting on social functioning and quality of life in schizophrenia. There is, however, a paucity of research into the underlying neurophysiological correlates of empathy deficits in this disorder. Accordingly, we sought: (1) to identify whether dysfunctional empathic abilities in schizophrenia are related to alterations in early or late brain processes, and (2) to explore the potential relationship between brain activity and mood, self-reported empathy and symptom severity...
July 30, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27067067/systematic-review-of-cognitive-effects-of-electroconvulsive-therapy-in-late-life-depression
#18
Sanjeev Kumar, Benoit H Mulsant, Angela Y Liu, Daniel M Blumberger, Zafiris J Daskalakis, Tarek K Rajji
OBJECTIVE: Late-life depression (LLD) is known to negatively impact cognition even after remission of mood symptoms. Electroconvulsive therapy (ECT) and newer nonconvulsive electrical and magnetic brain stimulation interventions have been shown to have cognitive effects in patients with neuropsychiatric disorders. METHODS: This review systematically assessed the effects of ECT on cognition in LLD. EMBASE, Ovid Medline, and PsycINFO were systematically searched through June 2015...
July 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27067066/decreased-brain-derived-neurotrophic-factor-in-older-adults-with-bipolar-disorder
#19
Aline T Soares, Ana C Andreazza, Soham Rej, Tarek K Rajji, Ariel G Gildengers, Beny Lafer, L Trevor Young, Benoit H Mulsant
OBJECTIVES: Decreased levels of brain derived neurotrophic factor (BDNF) have been found in adult patients with bipolar disorder (BD) compared with a comparison group, yet there are no data specifically examining this in geriatric patients. The objective of this study was to examine whether euthymic late-life BD patients have lower BDNF levels than healthy comparators. DESIGN: Cross-sectional study. SETTING: Clinics at the University of Pittsburgh and the Centre for Addiction and Mental Health (Toronto)...
August 2016: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/26874188/future-oriented-thought-patterns-associated-with-anxiety-and-depression-in-later-life-the-intriguing-prospects-of-prospection
#20
Beyon Miloyan, Nancy A Pachana, Thomas Suddendorf
Anxiety and mood disorders in later life are the focus of an increasing amount of intervention research, however basic mechanisms and paradigms explaining etiology and maintenance warrant further exploration. Research on future-oriented thought patterns associated with anxiety and depression in this age group may prove useful, as these disorders are both characterized by a tendency to generate and fixate on threat-related future scenarios that may or may not materialize. Additionally, depression is associated with a reduced expectancy of positive future events...
February 13, 2016: Gerontologist
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