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Treatment of bipolar disorder

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https://www.readbyqxmd.com/read/28734929/aripiprazole-prevents-renal-ischemia-reperfusion-injury-in-rats-probably-through-nitric-oxide-involvement
#1
Hanieh Gholampour, Leila Moezi, Hamed Shafaroodi
Renal ischemia/reperfusion (I/R) injury is strongly related to morbidity and mortality. Oxidative stress, inflammation, and apoptosis play key roles in renal dysfunction following renal I/R. Aripiprazole is an atypical antipsychotic which used for the treatment of schizophrenia and bipolar disorder. Recent studies have reported aripiprazole as displaying certain anti-inflammatory effects. Regarding the underlying mechanisms of renal ischemia-reperfusion, therefore, nephroprotective effects might be predicted to be seen with aripiprazole...
July 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28731778/a-pharmacologic-algorithm-for-youth-who-are-at-high-risk-for-bipolar-disorder
#2
Christopher D Schneck, Kiki D Chang, Manpreet K Singh, Melissa P DelBello, David J Miklowitz
OBJECTIVE: Depression and brief periods of manic symptoms are linked to a significant risk of progression to bipolar disorder (BD) in children who have a first-degree relative with BD I or II. However, little evidence exists to guide the pharmacologic management of children with these high-risk phenotypes. We propose a pharmacological treatment algorithm for high-risk youth and present results on its use in a study of children with a first-degree relative with BD. METHODS: Subjects were 40 youth (mean 12...
July 21, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28730183/aberrant-cerebellar-connectivity-in-bipolar-disorder-with-psychosis
#3
Ann K Shinn, Youkyung S Roh, Caitlin T Ravichandran, Justin T Baker, Dost Öngür, Bruce M Cohen
BACKGROUND: The cerebellum, which modulates affect and cognition in addition to motor functions, may contribute substantially to the pathophysiology of mood and psychotic disorders, such as bipolar disorder. A growing literature points to cerebellar abnormalities in bipolar disorder. However, no studies have investigated the topographic representations of resting state cerebellar networks in bipolar disorder, specifically their functional connectivity to cerebral cortical networks. METHODS: Using a well-defined cerebral cortical parcellation scheme as functional connectivity seeds, we compared ten cerebellar resting state networks in 49 patients with bipolar disorder and a lifetime history of psychotic features and 55 healthy control participants matched for age, sex, and image signal-to-noise ratio...
July 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28728937/the-impact-of-machine-learning-techniques-in-the-study-of-bipolar-disorder-a-systematic-review
#4
REVIEW
Diego Librenza-Garcia, Bruno Jaskulski Kotzian, Jessica Yang, Benson Mwangi, Bo Cao, Luiza Nunes Pereira Lima, Mariane Bagatin Bermudez, Manuela Vianna Boeira, Flávio Kapczinski, Ives Cavalcante Passos
Machine learning techniques provide new methods to predict diagnosis and clinical outcomes at an individual level. We aim to review the existing literature on the use of machine learning techniques in the assessment of subjects with bipolar disorder. We systematically searched PubMed, Embase and Web of Science for articles published in any language up to January 2017. We found 757 abstracts and included 51 studies in our review. Most of the included studies used multiple levels of biological data to distinguish the diagnosis of bipolar disorder from other psychiatric disorders or healthy controls...
July 17, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28726159/diagnosis-and-treatment-delays-among-elderly-breast-cancer-patients-with-pre-existing-mental-illness
#5
Kristy Iglay, Melissa L Santorelli, Kim M Hirshfield, Jill M Williams, George G Rhoads, Yong Lin, Kitaw Demissie
PURPOSE: This study aimed to compare diagnosis and treatment delays in elderly breast cancer patients with and without pre-existing mental illness. METHODS: A retrospective cohort study was conducted using the Surveillance, Epidemiology and End Results-Medicare data including 16,636 women 68+ years, who were diagnosed with stage I-IIIa breast cancer in the United States from 2005 to 2007. Mental illness was identified using International Classification of Diseases, Ninth Revision, Clinical Modification codes recorded on inpatient and outpatient claims during the 3 years prior to breast cancer diagnosis...
July 19, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28726075/effectiveness-adverse-effects-and-drug-compliance-of-long-acting-injectable-risperidone-in-children-and-adolescents
#6
Mehmet Fatih Ceylan, Betül Erdogan, Selma Tural Hesapcioglu, Esra Cop
BACKGROUND AND OBJECTIVES: Although the use of oral risperidone in children and adolescents has been well studied, there is little information on the intramuscular use of long-acting injectable risperidone (LAIR). The aims of this study were to investigate the effectiveness and adverse effects of LAIR in children and adolescents with conduct disorder, bipolar disorder, and schizophrenia. METHODS: In total, 42 patients (age range 12-17 years) who were non-adherent to oral antipsychotic drugs, received 25 mg/day of LAIR intramuscularly every 2 weeks...
July 19, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28725956/non-suicidal-self-injury-in-pediatric-bipolar-disorder-clinical-correlates-and-impact-on-psychosocial-treatment-outcomes
#7
Heather A MacPherson, Sally M Weinstein, Amy E West
Non-suicidal self-injury (NSSI) in childhood is not well documented, especially among youth with pediatric bipolar disorder (PBD). The current study evaluated prevalence and correlates of NSSI, and its impact on intervention response, in a randomized trial of Child- and Family-Focused Cognitive-Behavioral Therapy (CFF-CBT) versus Treatment As Usual (TAU), adjunctive to pharmacotherapy. This study included 72 children ages 7-13 (58% male) with PBD. NSSI and correlates were assessed at baseline; mood and psychiatric severity were measured longitudinally...
July 20, 2017: Journal of Abnormal Child Psychology
https://www.readbyqxmd.com/read/28724129/association-of-cost-sharing-with-mental-health-care-use-involuntary-commitment-and-acute-care
#8
Bastian Ravesteijn, Eli B Schachar, Aartjan T F Beekman, Richard T J M Janssen, Patrick P T Jeurissen
Importance: A higher out-of-pocket price for mental health care may lead not only to cost savings but also to negative downstream consequences. Objective: To examine the association of higher patient cost sharing with mental health care use and downstream effects, such as involuntary commitment and acute mental health care use. Design, Setting, and Participants: This difference-in-differences study compared changes in mental health care use by adults, who experienced an increase in cost sharing, with changes in youths, who did not experience the increase and thus formed a control group...
July 19, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/28724024/stigma-related-to-bipolar-disorder-in-the-perception-of-psychiatrists-from-belo-horizonte-minas-gerais-state-brazil
#9
Adauto Silva Clemente, Wagner Jorge Dos Santos, Rodrigo Nicolato, Josélia Oliveira Araújo Firmo
This research sought to understand meanings and implications of the stigma related to bipolar disorder in relation to social processes and local cultural value systems. Seven semidirected individual interviews were performed with psychiatrists (from Belo Horizonte city, Minas Gerais State, Brazil) and analyzed with referential from the Medical Anthropology. Some potential stigmatizing views about bipolar disorder patients were endorsed by respondents related to biomedical model of bipolar disorder. They claimed about the extreme trivialization of this diagnosis nowadays and observed that, in spite of the mitigation of stigma related to bipolar disorder over time, it remains an important issue, especially at labor fields and as a cause of refusal of treatment...
July 13, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28720617/protocol-for-an-online-randomised-controlled-trial-to-evaluate-the-clinical-and-cost-effectiveness-of-a-peer-supported-self-management-intervention-for-relatives-of-people-with-psychosis-or-bipolar-disorder-relatives-education-and-coping-toolkit-react
#10
Fiona Lobban, Heather Robinson, Duncan Appelbe, Johanna Barraclough, Emma Bedson, Lizzie Collinge, Susanna Dodd, Sue Flowers, Mahsa Honary, Sonia Johnson, Ceu Mateus, Barbara Mezes, Valerie Minns, Elizabeth Murray, Andrew Walker, Paula Williamson, Catherine Wintermeyer, Steven Jones
INTRODUCTION: Despite clinical guidelines recommendations, many relatives of people with psychosis or bipolar disorder do not currently receive the support they need. Online information and support may offer a solution. METHODS AND ANALYSIS: This single-blind, parallel, online randomised controlled trial will determine clinical and cost-effectiveness of the Relatives Education And Coping Toolkit (REACT) (including an online resource directory (RD)), compared with RD only, for relatives of people with psychosis or bipolar disorder...
July 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28715727/efficacy-and-safety-of-long-term-antidepressant-treatment-for-bipolar-disorders-a-meta-analysis-of-randomized-controlled-trials
#11
Bangshan Liu, Yan Zhang, Han Fang, Jin Liu, Tiebang Liu, Lingjiang Li
OBJECTIVE: Efficacy and safety of long-term use of antidepressants (AD) in bipolar disorder (BD) patients remains highly controversial. Here we performed a meta-analysis of randomized controlled trials (RCTs) exploring the efficacy and safety of long-term AD use in BD patients. METHODS: English-written literature published in peer-reviewed journal was systematically searched from Pubmed, EMBASE, CENTRAL, PsycINFO and Clinicaltrials.gov. Each database was searched from its first available time to August 31, 2016...
July 11, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28715621/electroconvulsive-therapy-during-pregnancy
#12
Aubrey Thyen, Puneet Narang, Simrat Sarai, Gulay Tegin, Steven Lippmann
Women often experience worsening mood disorder symptoms during pregnancy. Women with mood disorders have an increased risk for suboptimal prenatal care, inadequate weight gain, and more substance abuse during pregnancy. It is often difficult to balance pharmacotherapy risks to a developing fetus versus not medicinally treating maternal mental health conditions. Electroconvulsive therapy (ECT) is a rapid and effective treatment option that can be an appropriate intervention in some women during pregnancy. This report presents an overview of ECT in pregnancy and the case of a 28-year-old pregnant woman with bipolar mania who responded well to ECT...
July 13, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/28714575/rate-and-predictors-of-conversion-from-unipolar-to-bipolar-disorder-a-systematic-review-and-meta-analysis
#13
REVIEW
Lars Vedel Kessing, Inge Willer, Per Kragh Andersen, Jens Drachman Bukh
OBJECTIVES: For the first time to present a systematic review and meta-analysis of the conversion rate and predictors of conversion from unipolar disorder to bipolar disorder. METHODS: A systematic literature search up to October 2016 was performed. For the meta-analysis, we only included studies that used survival analysis to estimate the conversion rate. RESULTS: A total of 31 studies were identified, among which 11 used survival analyses, including two register-based studies...
July 17, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28712531/the-role-of-tryptophan-metabolism-and-food-craving-in-the-relationship-between-obesity-and-bipolar-disorder
#14
N Dalkner, M Platzer, S A Bengesser, A Birner, F T Fellendorf, R Queissner, A Painold, H Mangge, D Fuchs, B Reininghaus, H P Kapfhammer, S J Holasek, E Z Reininghaus
BACKGROUND & AIMS: Individuals with bipolar disorder (BD) have a significantly increased risk of obesity-related conditions. The imbalance between food intake and energy expenditure is assumed to be a major risk factor for obesity in BD. This study analyzed food craving in relation to anthropometric, metabolic, and neurobiological parameters in a well-characterized cohort of euthymic individuals with BD. METHODS: One-hundred-thirty-five patients completed the Food-Craving Inventory assessing four categories of food craving (fat, fast-food, sweets and carbohydrate craving)...
July 4, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28711743/is-a-simple-smartphone-application-capable-of-improving-biological-rhythms-in-bipolar-disorder
#15
Diego Hidalgo-Mazzei, María Reinares, Ainoa Mateu, Mario F Juruena, Allan H Young, Víctor Pérez-Sola, Eduard Vieta, Francesc Colom
BACKGROUND: Biological rhythms (BR) disturbance has been suggested as a potential mediator of mood episodes in Bipolar Disorder (BD). The Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) was designed as an assessment tool to evaluate BR domains comprehensively. In the context of a trial evaluating a smartphone application delivering personalized psychoeducational contents for BD (SIMPLe 1.0), the main aim of this study is to evaluate the potential impact of SIMPLe 1...
July 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28711473/interaction-of-reelin-and-stress-on-immobility-in-the-forced-swim-test-but-not-dopamine-mediated-locomotor-hyperactivity-or-prepulse-inhibition-disruption-relevance-to-psychotic-and-mood-disorders
#16
Michael J Notaras, Billie Vivian, Carey Wilson, Maarten van den Buuse
RATIONALE: Psychotic disorders, such as schizophrenia, as well as some mood disorders, such as bipolar disorder, have been suggested to share common biological risk factors. One such factor is reelin, a large extracellular matrix glycoprotein that regulates neuronal migration during development as well as numerous activity-dependent processes in the adult brain. The current study sought to evaluate whether a history of stress exposure interacts with endogenous reelin levels to modify behavioural endophenotypes of relevance to psychotic and mood disorders...
July 13, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28709116/morbidity-persistence-and-comorbidity-of-mood-anxiety-and-eating-disorders-among-preoperative-bariatric-patients
#17
Leorides Severo Duarte-Guerra, Bruno Mendonça Coêlho, Marco Aurélio Santo, Francisco Lotufo-Neto, Yuan-Pang Wang
The current study investigates the patterns of disease persistence and comorbidity of psychiatric disorders among patients with class III obesity in pre-operative period. For 393 treatment-seeking patients with severe obesity recruited from a bariatric center, we ascertained their psychiatric diagnosis through Structured Clinical Interview for DSM-IV (SCID-I). Following, the frequency, persistence and comorbidity pattern of psychiatric disorders in this sample were determined. Current psychiatric disorders were observed in over half of patients during preoperative period, being anxiety disorders the most frequent diagnosis...
July 10, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28709024/neurocognition-in-patients-with-psychotic-and-non-psychotic-bipolar-i-disorder-a-comparative-study-with-individuals-with-schizophrenia
#18
Estela Jiménez-López, Ana Isabel Aparicio, Eva Maria Sánchez-Morla, Roberto Rodriguez-Jimenez, Eduard Vieta, José Luis Santos
BACKGROUND: It has been suggested that patients with bipolar disorder with psychotic symptoms (BD-P) have larger neurocognitive impairment than patients with bipolar disorder without a history of psychotic symptoms (BD-NP). The objective of this study was to compare neurocognitive performance of BD-P and BD-NP relative to a group of patients with schizophrenia (SZ), and healthy controls (HC). METHODS: Neurocognitive function was examined in 100 subjects with bipolar I disorder (50 BD-P, 50 BD-NP), 50 SZ, and 51 HC...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28709018/adhd-research-in-india-a-narrative-review
#19
REVIEW
Pooja Patnaik Kuppili, Harshini Manohar, Raman Deep Pattanayak, Rajesh Sagar, Balaji Bharadwaj, Preeti Kandasamy
INTRODUCTION: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with no clear etiopathogenesis. Owing to unique socio cultural milieu of India, it is worthwhile reviewing research on ADHD from India and comparing findings with global research. Thereby, we attempted to provide a comprehensive overview of research on ADHD from India. METHODS: A boolean search of articles published in English from September 1966 to January 2017 on electronic search engines Google Scholar, PubMed, IndMED, MedIND, using the search terms "ADHD", "Attention Deficit and Hyperactivity Disorder", "Hyperactivity" ,"Child psychiatry", "Hyperkinetic disorder", "Attention Deficit Disorder", "India"was carried out and peer - reviewed studies conducted among human subjects in India were included for review...
July 5, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28706563/quality-of-life-in-children-and-adolescents-with-bipolar-i-depression-treated-with-olanzapine-fluoxetine-combination
#20
Daniel J Walker, Melissa P DelBello, John Landry, Deborah N D'Souza, Holland C Detke
BACKGROUND: We examined the efficacy of olanzapine/fluoxetine combination (OFC) in improving health-related quality of life (QoL) in the treatment of bipolar depression in children and adolescents. METHODS: Patients aged 10-17 years with bipolar I disorder, depressed episode, baseline children's depression rating scale-revised (CDRS-R) total score ≥40, Young Mania Rating Scale (YMRS) total score ≤15, and YMRS-item 1 ≤ 2 were randomized to OFC (6/25-12/50 mg/day olanzapine/fluoxetine; n = 170) or placebo (n = 85) for up to 8 weeks of double-blind treatment...
2017: Child and Adolescent Psychiatry and Mental Health
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