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Treatment of bipolar disorder

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https://www.readbyqxmd.com/read/29220679/interaction-between-pre-treatment-drug-use-and-heterogeneity-of-psychiatric-diagnosis-predicts-outcomes-in-outpatients-with-co-occurring-disorders
#1
Oladunni Oluwoye, Katherine Hirchak, Emily Leickly, Jordan Skalisky, Sterling McPherson, Debra Srebnik, John M Roll, Richard K Ries, Michael G McDonell
We examined whether the interaction of baseline stimulant use, assessed by urine drug tests, and type of serious mental illness (SMI) diagnosis predicted stimulant use in a trial of contingency management (CM). The interaction between baseline stimulant use and SMI diagnoses was significant in the overall sample (p=0.002) when controlling for the main effects of treatment condition, baseline stimulant use, and SMI diagnosis. Similar results were also found within the CM sample. Individuals with bipolar disorder were more or less likely, depending on their baseline stimulant-drug test results, to use stimulants during treatment compared to those with other SMI diagnoses...
November 29, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29216484/beliefs-about-the-causes-of-and-treatments-for-depression-and-bipolar-disorder-among-south-koreans
#2
Subin Park, Hyesue Jang, Adrian Furnham, Mina Jeon, Se Jin Park
Public beliefs about psychiatric disorders are important for understanding help-seeking behaviours. We investigated factors that affect South Koreans' beliefs about the causes and treatment of depression and bipolar disorder. We recruited 654 participants aged 15-54 years using an online panel survey. Participants completed two questionnaires: 34 possible causes of and 33 possible treatments for depression and bipolar disorder. For both disorders, the questionnaires about causes revealed four factors: social-environmental, God/fate, heath/lifestyle, and biological; the questionnaires about treatments revealed five factors: self-help/stress management, physical treatment/health management, seeking mental health services, religious help, and resting...
November 21, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29212563/clinically-relevant-and-simple-immune-system-measure-is-related-to-symptom-burden-in-bipolar-disorder
#3
Ole Köhler-Forsberg, Louisa Sylvia, Thilo Deckersbach, Michael Joshua Ostacher, Melvin McInnis, Dan Iosifescu, Charles Bowden, Susan McElroy, Joseph Calabrese, Michael Thase, Richard Charles Shelton, Mauricio Tohen, James Kocsis, Edward Friedman, Terence Ketter, Andrew Alan Nierenberg
OBJECTIVE: Immunological theories, particularly the sickness syndrome theory, may explain psychopathology in mood disorders. However, no clinical trials have investigated the association between overall immune system markers with a wide range of specific symptoms including potential gender differences. METHODS: We included two similar clinical trials, the lithium treatment moderate-dose use study and clinical and health outcomes initiatives in comparative effectiveness for bipolar disorder study, enrolling 765 participants with bipolar disorder...
December 7, 2017: Acta Neuropsychiatrica
https://www.readbyqxmd.com/read/29208408/personalized-management-of-bipolar-disorder
#4
REVIEW
Martin Alda, Mirko Manchia
Bipolar disorder (BD) is one of the most serious psychiatric disorders. The rates of disability, the risk of suicide attempts and their high lethality, as well as frequent and severe psychiatric and medical comorbidities, put it among the major causes of mortality and disability worldwide. At the same time, many patients can do well when treated properly. In this review, we focus on those aspects of the clinical care that offer the potential of individualized approach, in the context of the recent technology driven advances in the comprehension of the neurobiological underpinnings of BD...
December 2, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29202862/coping-with-unusual-experiences-for-12-18-year-olds-cues-a-transdiagnostic-randomised-controlled-trial-of-the-effectiveness-of-cognitive-therapy-in-reducing-distress-associated-with-unusual-experiences-in-adolescent-mental-health-services-study-protocol-for
#5
Suzanne Jolley, Sophie Browning, Richard Corrigall, Kristin R Laurens, Colette Hirsch, Karen Bracegirdle, Kimberley Gin, Francesca Muccio, Catherine Stewart, Partha Banerjea, Elizabeth Kuipers, Philippa Garety, Majella Byrne, Juliana Onwumere, Evanthia Achilla, Paul McCrone, Richard Emsley
BACKGROUND: Childhood 'unusual experiences' (such as hearing voices that others cannot, or suspicions of being followed) are common, but can become more distressing during adolescence, especially for young people in contact with Child and Adolescent Mental Health Services (CAMHS). Unusual experiences that are distressing or have adverse life impact (UEDs) are associated with a range of current and future emotional, behavioural and mental health difficulties. Recommendations for psychological intervention are based on evidence from adult studies, with some support from small, pilot, child-specific evaluations...
December 4, 2017: Trials
https://www.readbyqxmd.com/read/29200571/adolescent-onset-x-linked-adrenoleukodystrophy-presenting-as-treatment-resistant-bipolar-disorder
#6
Anirban Ray, Satish Chandra Girimaji, Rose Dawn Bharath
A small proportion of bipolar disorder of adolescent onset can be secondary to underlying neurological disorder (secondary mania). We report a case of treatment-resistant mania secondary to cerebral form of adrenoleukodystrophy of adolescent onset. This case demonstrates the need for clinicians to be alert to the possibility of rare neurological diseases that can present with psychiatric manifestations.
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29200560/a-cross-sectional-study-to-estimate-cardiovascular-risk-factors-in-patients-with-bipolar-disorder
#7
Swetha Reddy Damegunta, Prasad Rao Gundugurti
Background: There is increasing recognition of cardiovascular mortality and comorbidity in bipolar disorder (BD) in the recent times. Framingham 10 years risk of coronary heart disease (CHD) has been a widely accepted as a reliable estimate of cardiovascular risk in the general population. A few studies have estimated the relative risk of developing CHD in BDs, in India. We attempt to present a cross-sectional data from a prospective study to estimate the 10 years cardiovascular risk in BD population...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29200553/sociodemographic-and-clinical-predictors-of-response-in-manic-episodes-a-naturalistic-prospective-cohort-study
#8
Jasmin Garg, Ajeet Sidana, B S Chavan, Shikha Goel
Background: Response to treatment of a manic episode is dependent on several sociodemographic and clinical factors as reported by researchers from other countries. The prescription of mood stabilizers and/or antipsychotics for manic episode depends on these factors. There is a lack of availability of data from India on this topic. Hence, this study was planned to identify the predictors of pharmacological response. Materials and Methods: Forty-two patients with a diagnosis of bipolar affective disorder current episode manic were enrolled and assessed for sociodemographic variables and clinical variables such as age of onset, family history, comorbidities, index episode, and number of past episodes...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29199810/ketamine-as-treatment-for-depression
#9
Tero Taiminen
Ketamine infusions administered intravenously 1 to 3 times per week are the quickest and most effective treatment for depression. Short-course ketamine medication is established treatment both for unipolar depression and depressive episodes of bipolar affective disorder. Ketamine is suitable for initiating the treatment for treatment-resistant depression, alleviation of suicidal tendencies, and treatment of depressive patients suffering from simultaneous pain. The safety of prolonged treatment with ketamine is not known to sufficient degree...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29199760/effectivity-and-cost-effectivity-of-the-maintenance-electroconvulsive-therapy-a-mirror-naturalistic-analysis
#10
Albert Cosculluela, Jesús Cobo, Erika Martínez-Amorós, Montse Paños, Angel M Santiago, Sara Crivillés, María Camposo, Joan C Oliva, Albert Granero, Diego J Palao
INTRODUCTION: Maintenance Electroconvulsive Therapy (mECT) is a biological long-term treatment in which patients receive ECT on periods from 2 to 4 weeks, during a variable period of time, usually for more than 6 months. Recent studies showed the efficacy of mECT in prevention of relapse and recurrences. Our study wants to demostrate the effectivity and cost-effectivity of this therapy in the naturalistic conditions of our area. METHODOLOGY: HASH(0x4649b70) DESIGN: Retrospective longitudinal study, with mirror analysis in naturalistic conditions...
November 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29199496/recent-trends-on-the-role-of-epigenomics-metabolomics-and-noncoding-rnas-in-rationalizing-mood-stabilizing-treatment
#11
Claudia Pisanu, Theodora Katsila, George P Patrinos, Alessio Squassina
Mood stabilizers are the cornerstone in treatment of mood disorders, but their use is characterized by high interindividual variability. This feature has stimulated intensive research to identify predictive biomarkers of response and disentangle the molecular bases of their clinical efficacy. Nevertheless, findings from studies conducted so far have only explained a small proportion of the observed variability, suggesting that factors other than DNA variants could be involved. A growing body of research has been focusing on the role of epigenetics and metabolomics in response to mood stabilizers, especially lithium salts...
December 4, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/29196390/network-meta-analysis-drawing-conclusions-regarding-trials-of-psychosocial-interventions-for-bipolar-disorder
#12
EDITORIAL
David J Miklowitz, Andrea Cipriani, Guy M Goodwin
Network meta-analysis (NMA) is a statistical technique for making direct and indirect comparisons between different treatment and control groups. Despite its many advantages, NMA may be misleading when evaluating networks that are disconnected, inconsistent or of low reliability and validity. We review how well the analysis of trials of adjunctive psychosocial treatment in bipolar disorder is served by NMA. We conclude with recommendations for future treatment trials in bipolar disorder and guidelines for NMAs...
December 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/29195773/cognitive-deficits-in-bipolar-disorders-implications-for-emotion
#13
REVIEW
Isabela M M Lima, Andrew D Peckham, Sheri L Johnson
Prominent cognitive deficits have been documented in bipolar disorder, and multiple studies suggest that these deficits can be observed among non-affected first-degree relatives of those with bipolar disorder. Although there is variability in the degree of cognitive deficits, these deficits are robustly relevant for functional outcomes. A separate literature documents clear difficulties in emotionality, emotion regulation, and emotion-relevant impulsivity within bipolar disorder, and demonstrates that these emotion-relevant variables are also central to outcome...
November 21, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29195125/effects-of-continuation-electroconvulsive-therapy-on-quality-of-life-in-elderly-depressed-patients-a-randomized-clinical-trial
#14
W Vaughn McCall, Sarah H Lisanby, Peter B Rosenquist, Mary Dooley, Mustafa M Husain, Rebecca G Knapp, Georgios Petrides, Matthew V Rudorfer, Robert C Young, Shawn M McClintock, Martina Mueller, Joan Prudic, Robert M Greenberg, Richard D Weiner, Samuel H Bailine, Nagy A Youssef, Laryssa McCloud, Charles H Kellner
We examined whether electroconvulsive therapy (ECT) plus medications ("STABLE + PHARM" group) had superior HRQOL compared with medications alone ("PHARM" group) as continuation strategy after successful acute right unilateral ECT for major depressive disorder (MDD). We hypothesized that scores from the Medical Outcomes Study Short Form-36 (SF-36) would be higher during continuation treatment in the "STABLE + PHARM" group versus the "PHARM" group. The overall study design was called "Prolonging Remission in Depressed Elderly" (PRIDE)...
November 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29195035/obstructive-sleep-apnea-as-a-complication-of-bipolar-disorder-and-its-treatment-a-review-and-approach-to-management
#15
Surinder S Moonga, David Mischoulon, John W Winkelman, Theodore A Stern
No abstract text is available yet for this article.
November 30, 2017: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29191037/the-treatment-of-bipolar-disorder-integrative-clinical-strategies-and-future-directionsedited-by-andr%C3%A3-f-carvalho-and-eduard-vieta-new-york-oxford-university-press-2017-528-pp-64-95-paperback
#16
https://www.readbyqxmd.com/read/29188907/prescribing-patterns-in-a-psychiatrically-referred-sample-of-youth-with-autism-spectrum-disorder
#17
Julia Shekunov, Janet Wozniak, Kristina Conroy, Elizabeth Pinsky, Maura Fitzgerald, Melissa F de Leon, Abigail Belser, Joseph Biederman, Gagan Joshi
OBJECTIVE: The aim of this study was to examine the pattern of psychopharmacologic interventions in a psychiatrically referred sample of youth with autism spectrum disorder (ASD). METHODS: This retrospective chart review aimed at collecting demographic and clinical information, including data on DSM-IV-TR criteria-based psychiatric disorders and related current medication treatment and response. Data were collected in December 2011. Clinicians identified the target disorder for each medication and any adverse events...
November 28, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29188027/recent-advances-in-the-understanding-and-management-of-bipolar-disorder-in-adults
#18
REVIEW
Janusz K Rybakowski
This article focuses on some aspects of recent progress in the neurobiology and treatment of bipolar disorder (BD) in adults. A molecular-genetic approach to the etiopathogenesis of the illness resulted in the findings of a genetic overlap between BD and other major psychiatric disorders. Furthermore, a poly-gene-environmental interaction in the development of the illness has been demonstrated. For the management of BD, new drugs with putative mood-stabilizing properties have been introduced in the past two decades...
2017: F1000Research
https://www.readbyqxmd.com/read/29184969/out-of-pocket-health-expenditures-in-patients-with-bipolar-disorder-anxiety-schizophrenia-and-other-psychotic-disorders-findings-from-a-study-in-a-psychiatry-outpatient-clinic-in-turkey
#19
Duygu Islek, Bulent Kilic, Berna Binnur Akdede
PURPOSE: The aim of this study is to explore the amount of OOP health expenditures and their determinants in patients with bipolar disorder, anxiety, schizophrenia and other psychotic disorders in a psychiatry outpatient clinic of Turkey. METHODS: The study group was 191 patients who attended to the Psychiatry Outpatient Clinic in June 2014. All patients were previously diagnosed with either 'bipolar disorder', 'anxiety disorder' or 'schizophrenia and other psychotic disorders'...
November 28, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29179662/patient-experience-with-healthcare-services-among-older-adults-with-serious-mental-illness-compared-to-the-general-older-population
#20
Karen L Fortuna, Matthew C Lohman, John A Batsis, Elizabeth A DiNapoli, Peter R DiMilia, Martha L Bruce, Stephen J Bartels
Objective To compare patient experience with healthcare services and providers among older patients (≥50 years old) with and without serious mental illness. Methods Using secondary data from the Medical Expenditures Panel Survey from 2003 through 2013, we compared adults aged 50 years and older with schizophrenia spectrum disorder ( n = 106), mood disorders (i.e., major depressive disorder and bipolar disorder) ( n = 419), and no serious mental illness ( n = 34,921). Results Older adults with schizophrenia spectrum disorder reported significantly worse provider communication than older adults without serious mental illness...
July 2017: International Journal of Psychiatry in Medicine
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