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https://www.readbyqxmd.com/read/29778787/efficacy-of-palbociclib-combinations-in-hormone-receptor-positive-metastatic-breast-cancer-patients-after-prior-everolimus-treatment
#1
Ajay Dhakal, Christina M Matthews, Ellis Glenn Levine, Kilian Elizabeth Salerno, Fan Zhang, Kazuaki Takabe, Amy P Early, Stephen B Edge, Tracy O'Connor, Thaer Khoury, Jessica S Young, Mateusz Opyrchal
PURPOSE: Outcome data on hormone receptor positive (HR+ ), human epidermal growth factor receptor 2 (HER2) nonamplified (HER2- ) metastatic breast cancer (MBC) treated with palbociclib after treatment with everolimus are lacking. The PALOMA-3 trial, showing benefit of palbociclib plus fulvestrant compared to fulvestrant alone in HR+ HER2- MBC after progression while receiving endocrine therapy excluded women previously treated with everolimus. The objective of this study was to examine outcomes of HR+ HER2- MBC with prior exposure to everolimus while receiving palbociclib-based therapy...
April 28, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29766363/palbociclib-in-highly-pretreated-metastatic-er-positive-her2-negative-breast-cancer
#2
G Hoste, K Punie, H Wildiers, B Beuselinck, I Lefever, E Van Nieuwenhuysen, S N Han, P Berteloot, N Concin, R Salihi, I Vergote, P Neven
PURPOSE: We aimed to investigate the role of palbociclib, a first-in-class cyclin-dependent kinase 4 and 6 inhibitor, in postmenopausal women with highly pretreated endocrine therapy-resistant metastatic breast cancer (MBC). METHODS: Between 28 September 2015 and 14 March 2017, a compassionate use program was established in the University Hospitals Leuven in which 82 postmenopausal women with estrogen receptor-positive, HER2-negative MBC were included after at least four lines of systemic treatment...
May 16, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29755499/genetic-dissection-of-maize-embryonic-callus-regenerative-capacity-using-multi-locus-genome-wide-association-studies
#3
Langlang Ma, Min Liu, Yuanyuan Yan, Chunyan Qing, Xiaoling Zhang, Yanling Zhang, Yun Long, Lei Wang, Lang Pan, Chaoying Zou, Zhaoling Li, Yanli Wang, Huanwei Peng, Guangtang Pan, Zhou Jiang, Yaou Shen
The regenerative capacity of the embryonic callus, a complex quantitative trait, is one of the main limiting factors for maize transformation. This trait was decomposed into five traits, namely, green callus rate (GCR), callus differentiating rate (CDR), callus plantlet number (CPN), callus rooting rate (CRR), and callus browning rate (CBR). To dissect the genetic foundation of maize transformation, in this study multi-locus genome-wide association studies (GWAS) for the five traits were performed in a population of 144 inbred lines genotyped with 43,427 SNPs...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29745800/interaction-between-graviception-and-carotid-baroreflex-function-in-humans-during-parabolic-flight-induced-microgravity
#4
Shigehiko Ogoh, Michaël Marais, Romain Lericollais, Pierre Denise, Peter B Raven, Hervé Normand
The aim of the present study was to assess carotid baroreflex (CBR) during acute changes in otolithic activity in humans. To address this question, we designed a set of experiments to identify the modulatory effects of microgravity on CBR function at a tilt angle of -2{degree sign}, which was identified to minimize changes in central blood volume during parabolic flight. During parabolic flight at 0g and 1g, CBR function curves were modelled from the heart rate (HR) and mean arterial pressure (MAP) responses to rapid pulse trains of neck pressure (NP) and neck suction (NS) ranging from +40 to -80 Torr; CBR control of HR (carotid-HR) and MAP (carotid-MAP) baroreflex function curves, respectively...
May 10, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29731810/governing-well-in-community-based-research-lessons-from-canada-s-hiv-research-sector-on-ethics-publics-and-the-care-of-the-self
#5
Adrian Guta, Stuart J Murray, Carol Strike, Sarah Flicker, Ross Upshur, Ted Myers
In this paper, we extend Michel Foucault's final works on the 'care of the self' to an empirical examination of research practice in community-based research (CBR). We use Foucault's 'morality of behaviors' to analyze interview data from a national sample of Canadian CBR practitioners working with communities affected by HIV. Despite claims in the literature that ethics review is overly burdensome for non-traditional forms of research, our findings suggest that many researchers using CBR have an ambivalent but ultimately productive relationship with institutional research ethics review requirements...
November 2017: Public Health Ethics
https://www.readbyqxmd.com/read/29724009/ko-t-bu-as-a-single-electron-donor-revisiting-the-halogenation-of-alkanes-with-cbr%C3%A2-and-ccl%C3%A2
#6
Katie J Emery, Allan Young, J Norman Arokianathar, Tell Tuttle, John A Murphy
The search for reactions where KO t Bu and other tert -alkoxides might behave as single electron donors led us to explore their reactions with tetrahalomethanes, CX₄, in the presence of adamantane. We recently reported the halogenation of adamantane under these conditions. These reactions appeared to mirror the analogous known reaction of NaOH with CBr₄ under phase-transfer conditions, where initiation features single electron transfer from a hydroxide ion to CBr₄. We now report evidence from experimental and computational studies that KO t Bu and other alkoxide reagents do not go through an analogous electron transfer...
May 1, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29716869/delivery-of-risperidone-from-gels-across-porcine-skin-in-vitro-and-in-vivo-in-rabbits
#7
Yuming Ning, Xiaojin Chen, Zhenwei Yu, Wenquan Liang, Fanzhu Li
The purpose of this study was to develop and evaluate a transdermal delivery system for RIS using hydrogels. First, the effects of different concentrations of hydroxypropyl methylcellulose and Carbomer 934 (CBR) on RIS permeation were investigated in porcine skin. The optimized formulation was chosen as the base gel to screen for penetration enhancers. The pharmacokinetics of the optimized RIS formulation was then studied in vitro in rabbits. A formulation with 0.5% CBR showed the highest RIS permeation and was selected as the base gel...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29693773/regulation-of-the-sperm-to-oocyte-transition-in-caenorhabditis-briggsae-hermaphrodites-by-the-cbr-met-2-and-cbr-fem-3-genes
#8
Aaron Loomis Berenson, Scott Everet Baird
In Caenorhabditis briggsae hermaphrodites, spermatogenesis begins in the L4 larval stage and persists into early adulthood. Oogenesis begins after spermatogenesis the sperm-to-oocyte transition is irreversible. The timing of this transition is thought to have evolved in response to selection to maximize intrinsic growth rate. Sperm-to-oocyte transitions occurred early in Cbr-met-2 and Cbr-fem-3 mutants. These early transitions resulted in reduced brood sizes but had little or no impact on intrinsic growth rate...
April 25, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29658443/evaluation-of-the-effect-of-uremic-serum-on-hepatic-reductase-functional-expression
#9
Osama Y Alshogran, Esra A F Al-Obaidi, Belal A Al-Husein, Ashraf O Oweis
BACKGROUND: The nonrenal clearance of drugs mediated by hepatic reduction is selectively altered by kidney disease. This study evaluated the influence of uremic serum on the expression and activity of reductase enzymes. METHODS: Human hepatocellular carcinoma cells (HepG2) were incubated with 5% pooled serum collected from patients with hemodialysis (pre- and post-dialysis session) or control subjects. The mRNA expression of various aldo-keto (AKR1C) and carbonyl (CBR) reductases were measured...
April 16, 2018: Drug Metabolism Letters
https://www.readbyqxmd.com/read/29609148/debromination-of-polybrominated-diphenyl-ethers-pbdes-by-zero-valent-zinc-mechanisms-and-predicting-descriptors
#10
Ting Tang, Guining Lu, Rui Wang, Huan Chen, Yingcong Fang, Kaibo Huang, Jiayi Zheng, Mengyao Zou, Xueqin Tao, Hua Yin, Zhi Dang
Polybrominated diphenyl ethers (PBDEs) are a class of brominated flame retardants that are ubiquitous in the environment. The physical and chemical properties of PBDEs make them difficult to degrade, with the conventional remediation methods being relatively inefficient. In this study, the reactivity of zero valent zinc (ZVZ) toward 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) was evaluated under aqueous solution. First-order rate constants (kobs ) for BDE-47 disappearance increased with decreased pH, which is attributed to the dissolution of surface zinc oxides that promote the contact between the active site on zinc surface and BDE molecules...
March 21, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29594360/a-phase-ii-multicenter-single-arm-trial-of-eribulin-as-first-or-second-line-chemotherapy-for-her2-negative-advanced-or-metastatic-breast-cancer-evaluation-of-efficacy-safety-and-patient-reported-outcomes
#11
Kosei Kimura, Mitsuhiko Iwamoto, Satoru Tanaka, Daigo Yamamoto, Katsuhide Yoshidome, Hiroyuki Ogura, Risa Terasawa, Nobuki Matsunami, Yuko Takahashi, Toshikatsu Nitta, Takashi Morimoto, Hiroya Fujioka, Kanako Kawaguchi, Kazuhisa Uchiyama
PURPOSE: Although eribulin is a suitable option for early-line treatment of metastatic breast cancer (MBC), data on first- or second-line use of eribulin for human epidermal growth factor receptor 2 (HER2)-negative MBC are still limited. Therefore, we conducted a phase II trial to investigate the efficacy and safety of eribulin for first- or second-line chemotherapy for HER2-negative MBC. MATERIALS AND METHODS: We performed a phase II, open-label, single-arm, multicenter study in Japan...
March 28, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29578177/the-clinical-benefit-of-epidermal-growth-factor-receptor-and-human-epidermal-growth-factor-receptor-2-targeted-agents-adding-to-endocrine-therapy-in-hormone-receptor-positive-breast-cancer
#12
Huan Li, Qing Zhai, Bo Yu
Objectives: Studies have suggested that the crosstalk between estrogen receptor and ErbB receptor is involved in endocrine therapy (ET) resistance, which might be overcome by drugs-targeting ErbB receptor. However, the results of clinical studies remain controversial. The aim of this meta-analysis was to evaluate the efficacy and safety of ErbB (mainly epidermal growth factor receptor and human epidermal growth factor receptor 2 [HER2]) inhibitors added to ET for hormone receptor-positive breast cancer patients...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29524348/elotuzumab-and-dexamethasone-for-relapsed-or-refractory-multiple-myeloma-patients-a-retrospective-study
#13
Zachary Gross, Ashkon Rahbari, Eric Wirtschafter, Tanya M Spektor, Kyle A Udd, Sean Bujarski, Michael Ghermezi, Jason D Nosrati, Aleksandra Vidisheva, Benjamin Eades, Gary Cecchi, Tina Maluso, Regina Swift, James R Berenson
OBJECTIVE: To evaluate the efficacy and safety of elotuzumab and dexamethasone (Ed) for relapsed or refractory multiple myeloma (RRMM) patients. METHOD: This retrospective study evaluated the efficacy and safety of Ed treatment for 21 RRMM patients, 11 of whom were considered lenalidomide-refractory, and all of whom had progressed on at least 1 prior steroid-containing regimen. We also evaluated the efficacy of adding lenalidomide to a subset of patients following progression from Ed...
March 10, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29515767/efficacy-of-histology-agnostic-and-molecularly-driven-her2-inhibitors-for-refractory-cancers
#14
Luc Cabel, Alina Fuerea, Ludovic Lacroix, Capucine Baldini, Patricia Martin, Antoine Hollebecque, Sophie Postel-Vinay, Andrea Varga, Rastilav Balheda, Anas Gazzah, Jean-Marie Michot, Aurélien Marabelle, Etienne Rouleau, Eric Solary, Thierry De Baere, Eric Angevin, Jean-Pierre Armand, Stefan Michiels, Jean Yves Scoazec, Samy Ammari, Fabrice André, Jean-Charles Soria, Christophe Massard, Loic Verlingue
A targeted therapy is recommended in case of ERBB2 alteration for breast and gastric carcinomas, but miscellaneous other tumor types are ERBB2- altered at low prevalence. Broadening the administration of HER2 inhibitors across tumor types and genomic alterations could benefit to patients with refractory metastatic tumors. Targeted next-generation-sequencing (tNGS) and comparative genomic hybridization array (CGH) have been performed on fresh tumor biopsies of patients included in the MOSCATO-01 and ongoing MOSCATO-02 trials to administrate HER2 inhibitors in case of ERBB2 pathogenic mutation of amplification...
February 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29513769/cortical-bone-repositioning-technique-for-horizontal-alveolar-bone-augmentation-a-case-series
#15
Kensuke Yamauchi, Shinnosuke Nogami, Yoshihiro Kataoka, Shigeto Koyama, Bernd Lethaus, Tetsu Takahashi
The objective of this study was to present a novel procedure for cortical bone repositioning (CBR) that maintains a secure space under the periosteum by replacement of the lateral cortex via fixation, employing titanium screws. Seven systemically healthy patients presenting with horizontal alveolar bone defects in radiographs and CT images were enrolled for CBR technique for horizontal alveolar bone augmentation. A lateral cortical bone block was cut in the defects and freed from the original bony surface. A screw was inserted into the block, and the block was placed laterally to allow fixation...
March 7, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29513051/spinal-cord-injury-rehabilitation-and-pressure-ulcer-prevention-after-the-2005-south-asian-earthquake-a-cbr-case-study-from-pakistan
#16
Jawad Chishtie, Farrukh Chishtie, Karen Yoshida, Robert Balogh
BACKGROUND: The 2005 South Asian earthquake led to large-scale injuries and disabilities in northern Pakistan, which were dealt with using various approaches. In this regard, a community-based rehabilitation approach was initiated in the Muzaffarabad district of Pakistan in early 2006, focused on preventing complications among persons with Spinal Cord Injury. This case study briefly describes its development, aims and service provision components, in addition to the distribution of injuries from the disaster...
March 7, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29497836/the-influence-of-the-carotid-baroreflex-on-dynamic-regulation-of-cerebral-blood-flow-and-cerebral-tissue-oxygenation-in-humans-at-rest-and-during-exercise
#17
Sushmita Purkayastha, Kaitlyn Maffuid, Xiaojie Zhu, Rong Zhang, Peter B Raven
PURPOSE: This preliminary study tested the hypothesis that the carotid baroreflex (CBR) mediated sympathoexcitation regulates cerebral blood flow (CBF) at rest and during dynamic exercise. METHODS: In seven healthy subjects (26 ± 1 years), oscillatory neck pressure (NP) stimuli of + 40 mmHg were applied to the carotid baroreceptors at a pre-determined frequency of 0.1 Hz at rest, low (10 ± 1W), and heavy (30 ± 3W) exercise workloads (WLs) without (control) and with α - 1 adrenoreceptor blockade (prazosin)...
March 1, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29495646/ontology-based-method-for-fault-diagnosis-of-loaders
#18
Feixiang Xu, Xinhui Liu, Wei Chen, Chen Zhou, Bingwei Cao
This paper proposes an ontology-based fault diagnosis method which overcomes the difficulty of understanding complex fault diagnosis knowledge of loaders and offers a universal approach for fault diagnosis of all loaders. This method contains the following components: (1) An ontology-based fault diagnosis model is proposed to achieve the integrating, sharing and reusing of fault diagnosis knowledge for loaders; (2) combined with ontology, CBR (case-based reasoning) is introduced to realize effective and accurate fault diagnoses following four steps (feature selection, case-retrieval, case-matching and case-updating); and (3) in order to cover the shortages of the CBR method due to the lack of concerned cases, ontology based RBR (rule-based reasoning) is put forward through building SWRL (Semantic Web Rule Language) rules...
February 28, 2018: Sensors
https://www.readbyqxmd.com/read/29457935/customized-titanium-lattice-structure-in-three-dimensional-alveolar-defect-an-initial-case-letter
#19
Marcus Seiler, Peer W Kaemmerer, Michael Peetz, Amely Gundula Hartmann
The aim of this initial case report was to provide a new protocol for the clinical application of a patient-specific titanium lattice structure (Yxoss CBR®, ReOSS, Filderstadt, Germany) for customized bone regeneration. To obtain a 3-dimensional reconstruction of a posterior mandible segment in a 61-year-old woman, a patient-specific titanium customized lattice structure was used. As graft material autogenous bone tissue mixed with xenogenic alloplastic material (Bio Oss®, Geistlich Pharma, Wolhusen, Switzerland) was obtained for reconstruction...
February 19, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29435979/ibrutinib-alone-or-with-dexamethasone-for-relapsed-or-relapsed-and-refractory-multiple-myeloma-phase-2-trial-results
#20
Paul G Richardson, William I Bensinger, Carol Ann Huff, Caitlin L Costello, Nikoletta Lendvai, Jesus G Berdeja, Larry D Anderson, David S Siegel, Daniel Lebovic, Sundar Jagannath, Jacob P Laubach, Keith E Stockerl-Goldstein, Long Kwei, Fong Clow, Laurence Elias, Zeena Salman, Thorsten Graef, Elizabeth Bilotti, Ravi Vij
Novel therapies with unique new targets are needed for patients who are relapsed/refractory to current treatments for multiple myeloma. Ibrutinib is a first-in-class, once-daily, oral covalent inhibitor of Bruton tyrosine kinase, which is overexpressed in the myeloma stem cell population. This study examined various doses of ibrutinib ± low-dose dexamethasone in patients who received ≥2 prior lines of therapy, including an immunomodulatory agent. Daily ibrutinib ± weekly dexamethasone 40 mg was assessed in 4 cohorts using a Simon 2-stage design...
March 2018: British Journal of Haematology
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