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https://www.readbyqxmd.com/read/29140367/compact-bolometric-radiometer-for-free-electron-lasers-in-a-wavelength-range-from-extreme-ultraviolet-to-x-rays
#1
Takahiro Tanaka, Masahiro Kato, Norio Saito, Shigeki Owada, Kensuke Tono, Makina Yabashi, Tetsuya Ishikawa
A reliable diagnostic device for free-electron lasers (FELs) is essential for both users and the evaluation of FEL sources and beamline optics. Here, we propose a compact bolometric radiometer (CBR) that can operate at room temperature. The CBR is mainly designed for FELs in the wavelength range from the extreme-ultraviolet (EUV) to x-rays; moreover, we confirmed that the proposed device can also be applied to synchrotron radiation. As an application of the CBR, we evaluated an FEL beamline transmission by means of bolometric technique in the EUV range for the first time, to the best of our knowledge...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29137418/a-randomized-phase-ii-study-of-aromatase-inhibitors-plus-metformin-in-pre-treated-postmenopausal-patients-with-hormone-receptor-positive-metastatic-breast-cancer
#2
Yannan Zhao, Chengcheng Gong, Zhonghua Wang, Jian Zhang, Leiping Wang, Sheng Zhang, Jun Cao, Zhonghua Tao, Ting Li, Biyun Wang, Xichun Hu
Background: Everolimus significantly improves progression-free survival (PFS) and has been approved to use in aromatase inhibitor pretreated patients with hormone receptor positive advanced breast cancer. Metformin has been shown to inhibit mTOR pathway, with more favorable safety profile, leading to this hypothesis-generating trial to assess whether metformin enhances the efficacy of aromatase inhibitors. Methods: 60 postmenopausal women with hormone receptor positive locally advanced or metastatic breast cancer were randomly assigned 1:1 to aromatase inhibitor (exemestane 25mg/d or letrozole 2...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137414/salvage-lymph-node-dissection-after-68-ga-psma-or-18-f-fec-pet-ct-for-nodal-recurrence-in-prostate-cancer-patients
#3
Annika Herlemann, Alexander Kretschmer, Alexander Buchner, Alexander Karl, Stefan Tritschler, Lina El-Malazi, Wolfgang P Fendler, Vera Wenter, Harun Ilhan, Peter Bartenstein, Christian G Stief, Christian Gratzke
The management of patients with biochemical recurrence (BCR) after definitive treatment for prostate cancer remains controversial. Our aim was to determine survival rates and complications of salvage lymph node dissection (sLND) in patients with recurrent prostate cancer after radical prostatectomy, while evaluating biochemical response (BR) with two different positron emission tomography/computed tomography (PET/CT) tracers used for preoperative imaging. sLND was performed in 104 patients diagnosed with isolated nodal recurrence on either (18)F-fluoroethylcholine ((18)F-FEC) or (68)Ga-PSMA-HBED-CC ((68)Ga-PSMA) PET/CT...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29124328/efficacy-of-combination-chemotherapy-using-irinotecan-and-nedaplatin-for-patients-with-recurrent-and-refractory-endometrial-carcinomas-preliminary-analysis-and-literature-review
#4
Morikazu Miyamoto, Masashi Takano, Mika Kuwahara, Hiroaki Soyama, Kento Kato, Hiroko Matuura, Takahiro Sakamoto, Kazuki Takasaki, Tadashi Aoyama, Tomoyuki Yoshikawa, Kenichi Furuya
PURPOSE: We aimed to retrospectively evaluate the efficacy and toxicity of an irinotecan hydrochloride (CPT) and nedaplatin (N) combination therapy for recurrent and refractory endometrial carcinoma, administered based on UGT1A1 genotype. METHODS: Between 2009 and 2017, 21 patients who received CPT-N therapy for recurrent endometrial carcinoma as second- or third-line chemotherapy at our hospital were identified. The CPT-N regimen included 40-70 mg/m(2) of CPT-11 on days 1, 8, and 15, and 50 mg/m(2) of nedaplatin on day 1, q4 weeks...
November 9, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29117945/adipocytes-sequester-and-metabolize-the-chemotherapeutic-daunorubicin
#5
Xia Sheng, Jean-Hugues Parmentier, Jonathan Tucci, Hua Pei, Omar Cortez-Toledo, Christina M Dieli-Conwright, Matthew J Oberley, Michael Neely, Etan Orgel, Stan G Louie, Steven D Mittelman
Obesity is associated with poorer outcome for many cancers. Previously, we observed that adipocytes protect acute lymphoblastic leukemia (ALL) cells from the anthracycline, daunorubicin. In this study, it is determined whether adipocytes clear daunorubicin from the tumor microenvironment (TME). Intracellular daunorubicin concentrations were evaluated using fluorescence. Daunorubicin and its largely inactive metabolite, daunorubicinol, were analytically measured in media, cells, and tissues using liquid chromatography/mass spectrometry (LC/MS)...
November 8, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29110674/characterization-of-endocannabinoids-and-related-acylethanolamides-in-the-synovial-fluid-of-dogs-with-osteoarthritis-a-pilot-study
#6
Carmela Valastro, Debora Campanile, Mariarosaria Marinaro, Delia Franchini, Fabiana Piscitelli, Roberta Verde, Vincenzo Di Marzo, Antonio Di Bello
BACKGROUND: Cannabis-based drugs have been shown to be effective in inflammatory diseases. A number of endocannabinoids including N- arachidonoylethanolamide (anandamide, AEA) and 2-arachidonyl glycerol (2-AG) with activity at the cannabinoid receptors (CBR) CBR1 and CBR2, have been identified. Other structurally related endogenous fatty acid compounds such as oleoylethanolamide (OEA) and palmitoyl ethanolamide (PEA) have been identified in biological tissues. These compounds do not bind to CBR but might be involved in facilitating the actions of directly acting endocannabinoids and thus are commonly termed "entourage" compounds due to their ability to modulate the endocannabinoid system...
November 6, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29093546/socio-demographic-and-injury-related-factors-contributing-to-activity-limitations-and-participation-restrictions-in-people-with-spinal-cord-injury-in-bangladesh
#7
Manzur Kader, Nirmala K P Perera, Mohammad Sohrab Hossain, Redwanul Islam
STUDY DESIGN: Cross-sectional study. OBJECTIVES: To identify socio-demographic and injury-related factors that contribute to activity limitations and participation restrictions in people with spinal cord injury (SCI) in Bangladesh. SETTING: Centre for the Rehabilitation of the Paralysed (CRP), Savar, Dhaka, Bangladesh. METHODS: This study involved 120 (83% men) participants with SCI; their median (interquartile range) age and injury duration were 34 (25-43) years and 5 (2-10) years, respectively...
November 2, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29090664/pharmacogenetics-of-metabolic-genes-of-anthracyclines-in-acute-myeloid-leukemia
#8
Juan Eduardo Megias-Vericat, David Martinez-Cuadron, Maria Jose Herrero, Salvador F Alino, Jose Luis Poveda, Miguel Angel Sanz, Pau Montesinos
BACKGROUND: Anthracyclines in combination with cytarabine have been the standard therapy for acute myeloid leukemia (AML) for decades with high efficacy. However, the majority of patients will show initial resistance or will relapse after initial complete remission. Genetic variability in genes involved in anthracyclines metabolic pathway could be one of the causes of the interindividual differences in clinical outcomes. METHODS: A systematic review of published studies in AML cohorts was carried out in order to analyze the influence of polymorphisms in genes of anthracycline metabolism on efficacy and toxicity...
November 1, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/29075843/-optimal-suppression-as-a-solution-to-the-paradoxical-cost-of-multitasking-examination-of-suppression-specificity-in-task-switching
#9
Maayan Katzir, Bnaya Ori, Nachshon Meiran
Switching between tasks necessitates maintaining tasks in high readiness, yet readiness creates paradoxical interference from these tasks when they are not currently required. "Optimal suppression", which targets just the interfering information, provides a partial solution to this paradox. By examining the carryover of suppression of a competitor stimulus-response (S-R) set from Trial N - 1 to Trial N, Meiran, Hsieh  and colleagues (Meiran  et al., J Exp Psychol Learn mem cognit 36:992-1002, 2010; Cognit Affect Behav Neurosci 11:292-308, 2011, and Hsieh et al...
October 27, 2017: Psychological Research
https://www.readbyqxmd.com/read/29060557/evaluating-the-association-between-cardiac-and-peripheral-resistance-arms-of-the-baroreflex
#10
Alberto Porta, Vlasta Bari, Giovanni Ranuzzi, Beatrice De Maria, Mara Malacarne, Massimo Pagani, Daniela Lucini
The study proposes an extension of cardiac baroreflex (cBR) sequence analysis, traditionally performed over spontaneous fluctuations of heart period and systolic arterial pressure, to typify peripheral resistance baroreflex (prBR) from spontaneous variations of peripheral resistances and diastolic arterial pressure. The prBR baroreflex sensitivity (BRSprBR) and percentage of prBR sequences (SEQ%prBR) were computed along with analogous quantities assessed over cBR (i.e. BRScBR and SEQ%cBR). The cBR and prBR were typified in healthy subjects at rest (REST) and during light bicycle ergometer exercise at 10 percent of the maximal effort (EXE)...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29048702/time-kill-assays-of-amphotericin-b-plus-anidulafungin-against-candida-tropicalis-biofilms-formed-on-two-different-biomaterials
#11
Marcelo E Fernández-Rivero, José L Del Pozo, Paula Ramírez, Eulogio Valentín, Alba Ruiz-Gaitán, Javier Pemán, Emilia Cantón
PURPOSE: To determine the fungicidal activity by time-killing assays of amphotericin B (AMB) combined with anidulafungin (ANF) against biofilms of 2 clinical isolates of Candida tropicalis and the reference strain ATCC® 750, developed on polytetrafluoroethylene (PTFE) and titanium, using the CDC Biofilm Reactor (CBR) as an in vitro model. METHODS: Biofilms were developed for 24 hours on the disk surfaces and then exposed to AMB (40 mg/L), ANF (8 mg/L), alone and combined...
October 18, 2017: International Journal of Artificial Organs
https://www.readbyqxmd.com/read/29036790/predictors-for-the-efficacy-of-endostar-combined-with-neoadjuvant-chemotherapy-for-stage-iiia-n2-nsclc
#12
Xiaoliang Zhao, Xiaohua Wen, Wei Wei, Yanjun Su, Jian You, Liqun Gong, Zhenfa Zhang, Meng Wang, Jianyu Xiao, Xiyin Wei, Changli Wang
BACKGROUND: Endostar (rh-endostatin) is a new recombinant human endostatin, which could inhibit cell proliferation, angiogenesis, and tumor growth. OBJECTIVE: To explore anti-angiogenesis short-term efficacy combined with neoadjuvant chemotherapy for stage IIIA (N2) non-small cell lung cancer (NSCLC), and identify the potential predictive factors. METHODS: We pathologically examined 26 patients diagnosed with stage IIIA (N2) NSCLC who received NP chemotherapy alone or combined with Endostar, respectively...
September 29, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29034670/-community-based-research-in-therapeutic-patient-education-practices-and-contributions-a-literature-review
#13
Olivia Gross, Vincent de Andrade, Rémi Gagnayre
INTRODUCTION: Community-based research (CBR) in health involves both researchers and people concerned by the results of the research. It aims to empower populations, using their exposure to the phenomenon being studied as a starting point. The use of CBR in the field of therapeutic patient education (TPE) is of interest, as the two share such characteristics as the desire to foster self-reliance and participation and a culture of interdisciplinarity. AIM: To characterize CBR in the therapeutic patient education field...
October 2, 2017: Santé Publique: Revue Multidisciplinaire Pour la Recherche et L'action
https://www.readbyqxmd.com/read/29028513/occurrence-and-significance-of-morphologic-changes-in-patients-with-metastatic-triple-negative-breast-cancer-treated-with-cabozantinib
#14
Atul B Shinagare, Bhanusupriya Somarouthu, Hao Guo, Sara M Tolaney, Nikhil H Ramaiya
OBJECTIVE: To compare performance of RECIST1.1 and Choi criteria in assessment of patients with metastatic triple-negative breast cancer treated with cabozantinib. METHODS: Thirty patients with metastatic triple-negative breast cancer enrolled in phase 2 clinical trial received cabozantinib. Clinical benefit rates assessed by prospectively determined RECIST1.1 and retrospectively assessed Choi criteria were compared. RESULTS: Decreased tumor density (≥15%) at first follow-up was seen in 22/30(73%) patients...
September 28, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29018414/development-of-a-click-beetle-luciferase-reporter-system-for-enhanced-bioluminescence-imaging-of-listeria-monocytogenes-analysis-in-cell-culture-and-murine-infection-models
#15
Sadeeq Ur Rahman, Michael Stanton, Pat G Casey, Angela Spagnuolo, Giuliano Bensi, Colin Hill, Kevin P Francis, Mark Tangney, Cormac G M Gahan
Listeria monocytogenes is a Gram-positive facultative intracellular pathogen that is widely used as a model organism for the analysis of infection biology. In this context, there is a current need to develop improved reporters for enhanced bioluminescence imaging (BLI) of the pathogen in infection models. We have developed a click beetle red luciferase (CBR-luc) based vector (pPL2CBR(opt)) expressing codon optimized CBR-luc under the control of a highly expressed Listerial promoter (PHELP) for L. monocytogenes and have compared this to a lux-based system expressing bacterial luciferase for BLI of the pathogen using in vitro growth experiments and in vivo models...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28987410/variable-dual-carbon-bromine-stable-isotope-fractionation-during-enzyme-catalyzed-reductive-dehalogenation-of-brominated-ethenes
#16
Angela Woods, Kevin Kuntze, Faina Gelman, Ludwik Halicz, Ivonne Nijenhuis
The potential of compound-specific stable isotope analysis (CSIA) to characterize biotransformation of brominated organic compounds (BOCs) was assessed and compared to chlorinated analogues. Sulfurospirillum multivorans and Desulfitobacterium hafniense PCE-S catalyzed the dehalogenation of tribromoethene (TBE) to either vinyl bromide (VB) or ethene, respectively. Significantly lower isotope fractionation was observed for TBE dehalogenation by S. multivorans (εC = -1.3 ± 0.2‰) compared to D. hafniense (εC = -7...
September 27, 2017: Chemosphere
https://www.readbyqxmd.com/read/28977718/sustained-cell-body-reactivity-and-loss-of-neun-in-a-subset-of-axotomized-bulbospinal-neurons-after-a-chronic-high-cervical-spinal-cord-injury
#17
Fannie Darlot, Stéphane Vinit, Valéry Matarazzo, Anne Kastner
Following central nervous system lesion, the ability of injured axons to regrowth may depend on the level and duration of the injured cell body response (CBR). Therefore, in order to investigate whether axotomized brainstem neurons maintain a durable growth-competent state after spinal cord injury, we studied the effect of a chronic C2 hemisection in rats on the expression of various CBR markers involved in axon regeneration, such as c-Jun, ATF-3, HSP27, NO synthase (NOS), and also of the neural mature phenotype marker NeuN, in the bulbospinal respiratory neurons as compared to the Gigantocellularis nucleus...
October 4, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28964267/opportunities-for-human-resources-for-health-and-rehabilitation-a-response-to-jesus-et-al
#18
EDITORIAL
Jessica Power, Joanne McVeigh, Brynne Gilmore, Malcolm MacLachlan
We welcome Jesus et al.'s paper, which makes an important contribution to the under-researched area of the physical rehabilitation workforce. The authors present recommendations to "advance a policy and research agenda for ensuring that an adequate rehabilitation workforce can meet the current and future rehabilitation health needs" (p. 1). We argue that their perspective could however be strengthened by adopting a stronger global perspective, including consideration of the needs of low-resource settings. In particular, we highlight the integral role of more effective sector and inter-sectoral governance, the opportunity to support the development of community-based rehabilitation (CBR), the lessons that can be learnt from human resources for health (HRH) research and practice more generally, and the recent developments in the global provision of assistive technologies...
September 30, 2017: Human Resources for Health
https://www.readbyqxmd.com/read/28956187/phase-ib-trial-of-ixabepilone-and-vorinostat-in-metastatic-breast-cancer
#19
Thehang Luu, Kyu-Pyo Kim, Suzette Blanchard, Bean Anyang, Arti Hurria, Lixin Yang, Jan H Beumer, George Somlo, Yun Yen
PURPOSE: To translate promising preclinical data on the combination of vorinostat and ixabepilone for metastatic breast cancer (MBC) into clinical trials. METHODS: We conducted a randomized two-arm Phase IB clinical trial of ascending doses of vorinostat and ixabepilone in prior -treated MBC patients. To determine the maximum tolerated dose (MTD), 37 patients were randomized to schedule A: every-3-week ixabepilone + vorinostat (days 1-14), or schedule B: weekly ixabepilone + vorinostat (days 1-7; 15-21) Pharmacokinetics were assessed...
September 27, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28938909/a-study-of-human-resource-competencies-required-to-implement-community-rehabilitation-in-less-resourced-settings
#20
REVIEW
Brynne Gilmore, Malcolm MacLachlan, Joanne McVeigh, Chiedza McClean, Stuart Carr, Antony Duttine, Hasheem Mannan, Eilish McAuliffe, Gubela Mji, Arne H Eide, Karl-Gerhard Hem, Neeru Gupta
BACKGROUND: It is estimated that over one billion persons worldwide have some form of disability. However, there is lack of knowledge and prioritisation of how to serve the needs and provide opportunities for people with disabilities. The community-based rehabilitation (CBR) guidelines, with sufficient and sustained support, can assist in providing access to rehabilitation services, especially in less resourced settings with low resources for rehabilitation. In line with strengthening the implementation of the health-related CBR guidelines, this study aimed to determine what workforce characteristics at the community level enable quality rehabilitation services, with a focus primarily on less resourced settings...
September 22, 2017: Human Resources for Health
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