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https://www.readbyqxmd.com/read/28220250/differing-roles-for-sur-2-med23-in-c-elegans-and-c-briggsae-vulval-development
#1
Karley K Mahalak, Abdulrahman M Jama, Steven J Billups, Adriana T Dawes, Helen M Chamberlin
Normal vulval development in the nematode Caenorhabditis briggsae is identical to that in the related Caenorhabditis elegans. However, several experiments suggest that there are differences between the two species with respect to the contribution of EGF/Ras signaling. To investigate these differences genetically, we have characterized a C. briggsae mutant strain that phenocopies the effect observed when C. briggsae animals are treated with U0126, an inhibitor of the EGF pathway component MEK. We identify that the gene affected in the mutant strain is Cbr-sur-2, which encodes a MED23 mediator complex protein that acts downstream of EGF signaling in C...
February 20, 2017: Development Genes and Evolution
https://www.readbyqxmd.com/read/28209763/revisiting-suppression-of-interspecies-hybrid-male-lethality-in-caenorhabditis-nematodes
#2
Lauren E Ryan, Eric S Haag
Within the nematode genus Caenorhabditis, C. briggsae and C. nigoni are among the most closely related species known. They differ in sexual mode, with C. nigoni retaining the ancestral XO male-XX female outcrossing system, while C. briggsae recently evolved self-fertility and an XX-biased sex ratio. Wild-type C. briggsae and C. nigoni can produce fertile hybrid XX female progeny, but XO progeny are either 100% inviable (when C. briggsae is the mother) or viable but sterile (when C. nigoni is the mother). A recent study provided evidence suggesting that loss of the Cbr-him-8 meiotic regulator in C...
February 16, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28198153/chronic-stress-in-lizards-studies-on-the-behavior-and-benzodiazepine-receptors-in-liolaemus-koslowskyi-and-cnemidophorus-tergolaevigatus
#3
Alejandra Soloaga, Mariana Pueta, Félix Benjamín Cruz, Jackelyn Melissa Kembro, Raul Hector Marin
Behavioral and physiological adaptive responses of animals facing chronic exposure to a single stressor may allow them to overcome its negative effects for future exposures to similar stressful situations. At chemical level, the GABAA /benzodiazepine complex is considered one of the main receptor systems involved in the modulation of stress-induced responses. Here, we describe the behavioral responses of two different lizard species, Liolaemus koslowskyi and Cnemidophorus tergolaevigatus exposed to three potential chronic stressful treatments: (a) high temperature, (b) forced swimming, and (c) simulated predator...
December 2016: Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology
https://www.readbyqxmd.com/read/28197838/the-growing-role-of-cdk4-6-inhibitors-in-treating-hormone-receptor-positive-advanced-breast-cancer
#4
REVIEW
Ami N Shah, Massimo Cristofanilli
Single-agent endocrine therapy has been the standard therapeutic choice for the management of hormone receptor (HR)-positive, Her2-negative advanced breast cancer (ABC) for decades. However, the rapidly accumulating data regarding the biological role and safety of CDK4/6 inhibitors and the first-in-class approval of palbociclib have made these novel agents an essential component of treatment for HR-positive ABC. In the frontline setting, palbociclib in combination with endocrine therapy showed an improvement in progression-free survival (PFS) by 10 months to nearly 25 months when compared with endocrine therapy alone and a clinical benefit rate (CBR = stable disease >24 weeks + partial response + complete response) of 85%...
January 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28179312/mds-aml-del-11-q14-share-common-morphological-features-despite-different-chromosomal-breakpoints
#5
Irene Dambruoso, Rosangela Invernizzi, Marina Boni, Rita Zappatore, Ilaria Giardini, Maria Paola Cavigliano, Barbara Rocca, Celeste Calvello, Raffaella Bastia, Marilena Caresana, Francesca Pasi, Rosanna Nano, Paolo Bernasconi
In myelodysplatic syndromes and acute myeloid leukemia (MDS/AML) deletion of the 11q14 region is a rare chromosomal defect (incidence: 0.6-1.0%), included within the intermediate risk criteria by the International Prognostic Scoring System. No fluorescence in situ hybridization (FISH) study has yet been performed to identify a common breakpoint region (CBR). In our study through FISH with bacterial artificial chromosomes and commercial probes, we analyzed seven patients with MDS/AML harboring 11q14 deletion on conventional cytogenetic analysis...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28111645/rearrangement-of-bis-alkylidynyl-phosphines-to-phospha-acyls
#6
Annie L Colebatch, Yong-Shen Han, Anthony F Hill, Manab Sharma, Rong Shang, Jas S Ward
A range of bis(alkylidynyl)phosphines RP{C[triple bond, length as m-dash]M(CO)2(Tp*)}2 (M = Mo, W; R = Cl, Ph, Cy; Tp* = hydrotris(dimethylpyrazolyl)borate) are obtained from the reactions of [M([triple bond, length as m-dash]CLi)(CO)2(Tp*)] with Cl2PR or alternatively via the palladium(0)-mediated reactions of [W([triple bond, length as m-dash]CBr)(CO)2(Tp*)] with RPH2 (R = Py, Cy). The complexes RP{C[triple bond, length as m-dash]W(CO)2(Tp*)}2 rearrange slowly (R = Cl) or on heating (R = Ph) to afford the isomeric phospha-acyls [W2(μ:η(1)-C;η(2)-C,P-CCPR)(CO)4(Tp*)2]...
January 23, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28092733/enzymatic-synthesis-of-an-ezetimibe-intermediate-using-carbonyl-reductase-coupled-with-glucose-dehydrogenase-in-an-aqueous-organic-solvent-system
#7
Zhi-Qiang Liu, Si-Chuan Dong, Huan-Huan Yin, Ya-Ping Xue, Xiao-Ling Tang, Xiao-Jian Zhang, Jun-Yao He, Yu-Guo Zheng
(4S)-3-[(5S)-5-(4-Fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one ((S)-ET-5) is an important chiral intermediate in the synthesis of chiral side chain of ezetimibe. Recombinant Escherichia coli expressing carbonyl reductase (CBR) was successfully constructed in this study. The total E. coli biomass and the specific activity of recombinant CBR in 5L fermenter culture were 10.9gDCWL(-1) and 14900.3Ug(-1)DCW, respectively. The dual-enzyme coupled biocatalytic process in an aqueous-organic biphasic solvent system was first constructed using p-xylene as the optimal organic phase under optimized reaction conditions, and 150gL(-1) (4S)-3-[5-(4-fluorophenyl)-1,5-dioxophentyl]-4-phenyl-1,3-oxazolidin-2-one (ET-4) was successfully converted to (S)-ET-5 with a conversion of 99...
April 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28092019/urb597-and-the-cannabinoid-win55-212-2-reduce-behavioral-and-neurochemical-deficits-induced-by-mptp-in-mice-possible-role-of-redox-modulation-and-nmda-receptors
#8
Angel Escamilla-Ramírez, Esperanza García, Guadalupe Palencia-Hernández, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Julio Sotelo, Abel Santamaría
Several physiological events in the brain are regulated by the endocannabinoid system (ECS). While synthetic cannabinoid receptor (CBr) agonists such as WIN55,212-2 act directly on CBr, agents like URB597, a fatty acid amide hydrolase (FAAH) inhibitor, induce a more "physiological" activation of CBr by increasing the endogenous levels of the endocannabinoid anandamide (AEA). Herein, we compared the pre- and post-treatment efficacy of URB597 and WIN55,212-2 on different endpoints evaluated in the toxic model produced by the mitochondrial toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice...
January 14, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28073821/learning-from-cross-border-reproduction
#9
Emily Jackson, Jenni Millbank, Isabel Karpin, Anita Stuhmcke
Drawing upon the preliminary findings of an Australian empirical project on cross-border reproduction (CBR), this article argues that regulators and policymakers could learn from the experiences of those who travel overseas in order to access fertility treatment and surrogacy. It makes four principal observations. First, the distinction between so-called 'altruistic' and 'commercial' gamete donation and surrogacy is increasingly unsustainable and is not experienced as meaningful by many participants in CBR...
January 10, 2017: Medical Law Review
https://www.readbyqxmd.com/read/28065934/brain-cannabinoid-receptor-2-expression-function-and-modulation
#10
REVIEW
De-Jie Chen, Ming Gao, Fen-Fei Gao, Quan-Xi Su, Jie Wu
Cannabis sativa (marijuana) is a fibrous flowering plant that produces an abundant variety of molecules, some with psychoactive effects. At least 4% of the world's adult population uses cannabis annually, making it one of the most frequently used illicit drugs in the world. The psychoactive effects of cannabis are mediated primarily through cannabinoid receptor (CBR) subtypes. The prevailing view is that CB1Rs are mainly expressed in the central neurons, whereas CB2Rs are predominantly expressed in peripheral immune cells...
January 9, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28059083/behavioral-determinants-of-cannabinoid-self-administration-in-old-world-monkeys
#11
William S John, Thomas J Martin, Michael A Nader
Reinforcing effects of Δ(9)-tetrahydrocannabinol (THC), the primary active ingredient in marijuana, as assessed with self-administration (SA), has only been established in New World primates (squirrel monkeys). The objective of this study was to investigate some experimental factors that may enhance intravenous SA of THC and the cannabinoid receptor (CBR) agonist CP 55 940 in Old World monkeys (rhesus and cynomolgus), a species that has been used extensively in biomedical research. In one experiment, male rhesus monkeys (N=9) were trained to respond under a fixed-ratio 10 schedule of food presentation...
February 1, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28057111/-health-economic-evaluation-of-a-23-value-pneumococcal-polysaccharide-vaccination-pilot-programme-among-elderly-chronic-obstructive-pulmonary-disease-patients-in-china
#12
Y P Qiu, K Zhao, X Li, L W Shi, W D Guo, X R Qi, B Y Sui, R M Zhou
Objective: From the perspective of health economics, to evaluate 23 pneumococcal polysaccharide vaccination programme among chronic obstructive pulmonary disease (COPD) patient. Methods: In the pilot counties of the project of integrated care pathway for COPD patient (Hanbin district of Hanzhong city in Shanxi Province, Qianjian district of Qingqing city, Huandao district of Qindao city in Shangdong Province, Wen county of Jiaozuo city in Henan Province), information of insurance participants of New Rural Cooperative Medical System (NRCS) was collected by local NRCM information system, which included general information as well as records of medical care and medical fee...
December 6, 2016: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28004349/geotechnical-assessment-of-road-failure-and-slope-monitoring-along-nsukka-adoru-idah-highway-southeastern-nigeria
#13
Raphael Iweanya Maduka, Ogbonnaya Igwe, Nnadozie Onyekachi Ayogu, Chinero Nneka Ayogu, Martin Nwachukwu
The quality of highway pavement is greatly influenced by the subgrade materials, the general geology of the area, and the materials used for construction. Investigation into the 75-km Nsukka-Adoru-Idah highway revealed that the pavement was underlain by three lithological units-Imo, Nsukka, and Ajali formations. The geotechnical evaluation carried out in the study includes the particle size distribution, Atterberg limit, specific gravity, compaction tests, and California bearing ratio (CBR). The base course has clay/silt (7-14%), fine sand (1-4%), medium sand (6-13%), and coarse sand (65-86%), while the subgrade presented clay/silt (74-82%), fine sand (6-9%), medium sand (10-17%), and coarse sand (1-3%)...
January 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27999832/high-oxidation-state-bromocarbyne-complexes
#14
Anthony F Hill, Richard Y Kong
Bromination of the carbyne complexes [W([triple bond, length as m-dash]CR)Br(CO)2(dcpe)] (R = Ph, SiPh3; dcpe = 1,2-bis(dicyclohexylphosphino)ethane) provides high oxidation state derivatives [W([triple bond, length as m-dash]CPh)Br3(dcpe)] and [W([triple bond, length as m-dash]CBr)Br3(dcpe)], the latter via an unprecedented bromodesilylation process.
December 21, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27996220/understanding-community-based-rehabilitation-and-the-role-of-physical-and-rehabilitation-medicine-a-discussion-paper
#15
Vanessa Seijas, Luz H Lugo, Blanca Cano, Luz M Escobar, Carlos Quintero, Boya Nugraha, Christoph Gutenbrunner
BACKGROUND: Community Based Rehabilitation (CBR) is an accepted model to improve the delivery of rehabilitation in the community. It includes the access to health care, education, labor and accessible environments. The role of Specialists in Physical and Rehabilitation Medicine in this strategy (SPRM) is not very well defined. METHODS: On the occasion of the international consultation for the WHO Action Plan for persons with disabilities, a discussion about the meaning of CBR and the role of SPRM on CBR has occurred among the International Society of Physical and Rehabilitation medicine (ISPRM) members...
December 19, 2016: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/27931828/targeting-mtor-pathway-in-gynecological-malignancies-biological-rationale-and-systematic-review-of-published-data
#16
REVIEW
Loay Kassem, Omar Abdel-Rahman
BACKGROUND: mTOR inhibitors are widely used in different malignancies with several trials testing their efficacy and safety in gynecological malignancies. We aimed to review the current evidence that support the expansion of using such drugs in the treatment of advanced gynecological cancers. METHODS: A comprehensive systematic review of literature has been conducted to include prospective trials that used everolimus, temsirolimus or ridaforolimus in the management of gynecological cancers and have available efficacy and toxicity results...
December 2016: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/27914737/targeted-proteomics-of-cannabinoid-receptor-cb1-and-the-cb1b-isoform
#17
Soumita Ghosh, Isabel González-Mariscal, Josephine M Egan, Ruin Moaddel
Cannabinoid receptors (CBR), including CB1 and CB2 have been therapeutic targets for a number of conditions. Recently, splice variants of the CB1R have been identified in humans. The isoforms differ in their N-terminus sequence and pharmacological activity relative to the CB1R, as a result, the differentiation between the CB1 receptor and its isoform is required. As a result, a selected reaction monitoring mass spectrometry (SRM-MS) method was developed for the quantitation of CB1 and the CB1b isoform in CHO cells transduced with CB1 and CB1b...
November 11, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27909367/ethics-and-community-based-rehabilitation-eight-ethical-questions-from-a-review-of-the-literature
#18
Stephen Clarke, Jessica Barudin, Matthew Hunt
Purpose: This article reviews the literature regarding ethics and community-based rehabilitation (CBR) with the goal of identifying and analyzing ethical considerations associated with this approach. Method: We conducted a critical interpretive review of the academic literature related to CBR in low- and middle-income countries and to indigenous communities in high-income countries. Using an inductive analysis of the collected articles, we identified five key topic areas related to ethical considerations. We then critically appraised this literature and developed eight questions that reflect areas of ethical tension, uncertainty, or debate...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27896440/a-phase-iii-open-label-randomized-multicenter-controlled-trial-of-oral-versus-intravenous-treosulfan-in-heavily-pretreated-recurrent-ovarian-cancer-a-study-of-the-north-eastern-german-society-of-gynecological-oncology-noggo
#19
RANDOMIZED CONTROLLED TRIAL
Jalid Sehouli, Oliver Tomè, Desislava Dimitrova, Oumar Camara, Ingo Bernhard Runnebaum, Hans Werner Tessen, Beate Rautenberg, Radoslav Chekerov, Mustafa Zelal Muallem, Michael Patrick Lux, Tanja Trarbach, Gerald Gitsch
OBJECTIVE: In recurrent ovarian cancer (ROC), there is a high demand on effective therapies with a mild toxicity profile. Treosulfan is an alkylating agent approved as oral (p.o.) and intravenous (i.v.) formulation for the treatment of recurrent ovarian cancer. Data on safety and efficacy for either formulation are rare. For the first time we conducted a randomized phase III study comparing both formulations in women with ROC. METHODS: Patients having received at least two previous lines of chemotherapy were randomly assigned to one of two treatment arms: treosulfan i...
March 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/27890725/functional-selectivity-at-g-protein-coupled-receptors-advancing-cannabinoid-receptors-as-drug-targets
#20
REVIEW
Srikrishnan Mallipeddi, David R Janero, Nikolai Zvonok, Alexandros Makriyannis
The phenomenon of functional selectivity, whereby a ligand preferentially directs the information output of a G-protein coupled receptor (GPCR) along (a) particular effector pathway(s) and away from others, has redefined traditional GPCR signaling paradigms to provide a new approach to structure-based drug design. The two principal cannabinoid receptors (CBRs) 1 and 2 belong to the class-A GPCR subfamily and are considered tenable therapeutic targets for several indications. Yet conventional orthosteric ligands (agonists, antagonists/inverse agonists) for these receptors have had very limited clinical utility due to their propensity to incite on-target adverse events...
November 24, 2016: Biochemical Pharmacology
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