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Diabetes in elderly

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https://www.readbyqxmd.com/read/28634202/hemoglobin-a1c-variability-predicts-symptoms-of-depression-in-elderly-individuals-with-type-2-diabetes
#1
Ramit Ravona-Springer, Anthony Heymann, James Schmeidler, Erin Moshier, Elizabeth Guerrero-Berroa, Laili Soleimani, Mary Sano, Derek Leroith, Rachel Preiss, Ruth Tzukran, Jeremy M Silverman, Michal Schnaider Beeri
OBJECTIVE: This study aimed to analyze the relationship of variability in hemoglobin A1c (HbA1c) over years with subsequent depressive symptoms. RESEARCH DESIGN AND METHODS: Subjects (n = 837) were participants of the Israel Diabetes and Cognitive Decline (IDCD) study, which aimed to examine the relationship of characteristics of long-term type 2 diabetes with cognitive decline. All pertain to a diabetes registry established in 1998, which contains an average of 18 HbA1c measurements per subject...
June 20, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28631524/the-association-between-social-jetlag-the-metabolic-syndrome-and-type-2-diabetes-mellitus-in-the-general-population-the-new-hoorn-study
#2
Anitra D M Koopman, Simone P Rauh, Esther van 't Riet, Lenka Groeneveld, Amber A van der Heijden, Petra J Elders, Jacqueline M Dekker, Giel Nijpels, Joline W Beulens, Femke Rutters
Only a few studies have investigated the metabolic consequences of social jetlag. Therefore, we examined the association of social jetlag with the metabolic syndrome and type 2 diabetes mellitus in a population-based cohort. We used cross-sectional data from the New Hoorn Study cohort ( n = 1585, 47% men, age 60.8 ± 6 years). Social jetlag was calculated as the difference in midpoint sleep (in hours) between weekdays and weekend days. Poisson and linear regression models were used to study the associations, and age was regarded as a possible effect modifier...
June 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28631057/diabetes-mellitus-a-risk-factor-for-seizures-in-the-elderly-a-population-based-study
#3
Marta Baviera, Maria Carla Roncaglioni, Mauro Tettamanti, Tommaso Vannini, Ida Fortino, Angela Bortolotti, Luca Merlino, Ettore Beghi
AIMS: To evaluate the association between diabetes mellitus (DM) and risk of seizures in a well-defined elderly population. METHODS: The administrative databases of the Lombardy region (a 10 million population area in Northern Italy) were used to identify persons aged 65 years or older with DM (defined by prescription of antidiabetic drugs and/or through ICD-9 CM code and/or exemption code for diabetes) during the year 2002. Seizure-free DM subjects were followed until 2012 in search of individuals with incident seizures (identified through ICD-9 CM codes for epilepsy/seizures or ATC codes for antiepileptic drugs associated with the prescription of an electroencephalogram)...
June 19, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28630829/are-we-justified-doing-salvage-or-amputation-procedure-based-on-mangled-extremity-severity-score-in-mangled-upper-extremity-injury
#4
R Siva Kumar, Prahalad Kumar Singhi, M Chidambaram
INTRODUCTION: Mangled upper limb injuries are at surge because of industrialization, modernization, and severe motor vehicle accidents. The utility of various scoring systems are meant for decision making in mangled lower limb injuries, and the same have been extrapolated for mangled upper limb injuries to make a decision of salvage or amputation for the lack of separate scoring system. MATERIALS AND METHODS: We applied mangled extremity severity score (MESS) and mangled extremity syndrome index (MESI) scoring systems to 10 cases of mangled upper limb injuries during the period of November 2010 to September 2012 presented at our tertiary trauma care center...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28627865/the-value-of-color-doppler-ultrasound-in-the-diagnosis-of-lower-extremity-vascular-disease-in-type-2-diabetes-and-an-analysis-of-related-factors
#5
Le Jiang, Yuehua Zhao
BACKGROUND: The aim of this paper is to explore the application and clinical significance of color Doppler ultrasound (CDU) in diagnosing lower extremity vascular disease in type 2 diabetes mellitus (T2DM) patients. METHODS: The lower extremity arteries of 81 patients with T2DM and 50 control patients were examined by CDU for blood vessel diameter, intima-media thickness, plaque on the vessel wall, lumen stenosis and filling defect in blood flow. The occurrence of diabetes mellitus was investigated in additional T2DM patients of various ages...
September 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/28626178/hypoglycemic-coma-induced-by-the-use-of-succinic-acid-cibenzoline-in-frail-late-stage-elderly-subjects
#6
Yurie Hirata, Shinji Kamei, Fuminori Tatsumi, Masashi Shimoda, Akihito Tanabe, Junpei Sanada, Yoshiro Fushimi, Shintaro Irie, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
Succinic acid cibenzoline (CZ) is an antiarrhythmic agent often used for the treatment of tachyarrhythmia. However, hypoglycemia should be avoided in the treatment of diabetes. We herein report two late-stage elderly subjects who experienced a severe and prolonged hypoglycemic coma after the usage of CZ. These cases suggest that, when CZ is administered to elderly subjects with renal dysfunction and/or frailty, we should be aware of the possibility that this medicine may induce hypoglycemia and should adjust the dose as appropriate and monitor the concentration of CZ to avoid severe hypoglycemia...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28622335/psychotic-symptoms-in-older-people-without-dementia-from-a-brazilian-community-based-sample-a-seven-years-follow-up
#7
Walter Barbalho Soares, Eriton Barros Dos Santos, Cássio Machado de Campos Bottino, Helio Elkis
BACKGROUND: Studies of the incidence of psychotic symptoms in elderly people at risk of dementia are scarce. This is a seven year follow up study aiming to determine the incidence of psychotic symptoms and their correlation with other clinical aspects, in particular the rate of development of cognitive impairment. METHODS: Cohort study of a community-based sample of elderly subjects. At study entry in 2004, the sample was composed of 1,125 individuals aged 60 years and older...
2017: PloS One
https://www.readbyqxmd.com/read/28621703/pain-sensation-in-human-osteoarthritic-knee-joints-is-strongly-enhanced-by-diabetes-mellitus
#8
Annett Eitner, Julia Pester, Franziska Vogel, Ivan Marintschev, Thomas Lehmann, Gunther O Hofmann, Hans-Georg Schaible
The major burden of knee joint osteoarthritis (OA) is pain. Since in elder patients diabetes mellitus is an important comorbidity of OA we explored whether the presence of diabetes mellitus has a significant influence on pain intensity at the end stage of knee OA, and we aimed to identify factors possibly related to changes of pain intensity in diabetic patients. In 23 diabetic and 47 non-diabetic OA patients undergoing total knee arthroplasty, we assessed the pain intensity before the operation using the "Knee injury and Osteoarthritis Outcome score" (KOOS)...
June 8, 2017: Pain
https://www.readbyqxmd.com/read/28617703/using-self-reports-or-claims-to-assess-disease-prevalence-it-s-complicated
#9
Patricia St Clair, Étienne Gaudette, Henu Zhao, Bryan Tysinger, Roxanna Seyedin, Dana P Goldman
BACKGROUND: Two common ways of measuring disease prevalence include (1) using self-reported disease diagnosis from survey responses; (2) using disease-specific diagnosis codes found in administrative data. Because they do not suffer from self-report biases, claims are often assumed to be more objective. However, it is not clear that claims always produce better prevalence estimates. OBJECTIVE: Conduct an assessment of discrepancies between self-report and claims-based measures for 2 diseases in the US elderly to investigate definition, selection, and measurement error issues which may help explain divergence between claims and self-report estimates of prevalence...
June 14, 2017: Medical Care
https://www.readbyqxmd.com/read/28616498/xenotransplantation-a-special-case-of-one-health
#10
REVIEW
Joachim Denner
The chronic shortage of human transplants to treat tissue and organ failure has led to the development of xenotransplantation, the transplantation of cells, tissues and organs from another species to human recipients. For a number of reasons, pigs are best suited as donor animals. Successful, routine xenotransplantation would have an enormous impact on the health of the human population, including the young, who sometimes require a replacement organ or islet cells, but especially the elderly, who more often suffer the consequences of organ failure...
June 2017: One Health
https://www.readbyqxmd.com/read/28616435/impact-of-pharmacist-intervention-on-appropriate-insulin-pen-use-in-older-patients-with-type-2-diabetes-mellitus-in-a-rural-area-in-iran
#11
Aida Sefidani Forough, Parsa Riazi Esfahani
OBJECTIVE: The aim of this study was to evaluate the impact of pharmacist-conducted educational intervention on reducing errors related to inappropriate insulin pen use. METHODS: This was a prospective, before-after study with an educational intervention component. The study was conducted on 122 elderly diabetic patients. Data were collected through interviews using researcher-administered questionnaires as well as patients' medical records. Patients were asked about the preparation, injection, and storage techniques, they followed when using insulin pens...
April 2017: Journal of Research in Pharmacy Practice
https://www.readbyqxmd.com/read/28615996/international-society-of-sports-nutrition-position-stand-safety-and-efficacy-of-creatine-supplementation-in-exercise-sport-and-medicine
#12
REVIEW
Richard B Kreider, Douglas S Kalman, Jose Antonio, Tim N Ziegenfuss, Robert Wildman, Rick Collins, Darren G Candow, Susan M Kleiner, Anthony L Almada, Hector L Lopez
Creatine is one of the most popular nutritional ergogenic aids for athletes. Studies have consistently shown that creatine supplementation increases intramuscular creatine concentrations which may help explain the observed improvements in high intensity exercise performance leading to greater training adaptations. In addition to athletic and exercise improvement, research has shown that creatine supplementation may enhance post-exercise recovery, injury prevention, thermoregulation, rehabilitation, and concussion and/or spinal cord neuroprotection...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28615249/reduction-in-podocyte-sirt1-accelerates-kidney-injury-in-aging-mice
#13
Peter Y Chuang, Weijing Cai, Xuezhu Li, Lu Fang, Jin Xu, Rabi Yacoub, John Cijiang He, Kyung Lee
Both the incidence and prevalence of chronic kidney disease are increasing in the elderly population. Although aging is known to induce kidney injury, the underlying molecular mechanisms remain unclear. Sirtuin 1 (Sirt1), a longevity gene, is known to protect kidney cell injury from various cellular stresses. In previous studies, we showed that the podocyte-specific loss of Sirt1 aggravates diabetic kidney injury. However, the role of Sirt1 in aging-induced podocyte injury is not known. Therefore, in this study we sought to determine the effects of podocyte-specific reduction of Sirt1 in age-induced kidney injury...
June 14, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28614282/clinical-outcomes-of-cervical-spinal-surgery-for-cervical-myelopathic-patients-with-coexisting-lumbar-spinal-canal-stenosis-tandem-spinal-stenosis-a-retrospective-analysis-of-297-cases
#14
Tsuyoshi Yamada, Toshitaka Yoshii, Naoki Yamamoto, Takashi Hirai, Hiroyuki Inose, Tsuyoshi Kato, Shigenori Kawabata, Atsushi Okawa
STUDY DESIGN: Retrospective observational study. OBJECTIVE: We evaluated the prevalence and clinical characteristics of tandem spinal stenosis (TSS) in patients with cervical myelopathy including ossification of the posterior longitudinal ligament of the cervical spine (C-OPLL). SUMMARY OF BACKGROUND DATA: Concurrent cervical and lumbar spinal canal stenosis is generally reported as TSS. Most previous studies have used magnetic resonance imaging to evaluate spinal stenosis in the cervical and lumbar spine...
June 13, 2017: Spine
https://www.readbyqxmd.com/read/28613287/geriatric-syndromes-and-not-cardiovascular-risk-factors-are-associated-with-cognitive-impairment-among-mexican-community-dwelling-elderly-with-type-2-diabetes
#15
Omar Yaxmehen Bello-Chavolla, Carlos Alberto Aguilar-Salinas, José Alberto Avila-Funes
BACKGROUND: The association of cognitive impairment and type 2 diabetes has been consistently shown in several studies, yet its association with geriatric syndromes has not been fully explored. OBJECTIVE: To study the correlates of cognitive impairment among community-dwelling elderly with type 2 diabetes. METHODS: Cross-sectional study of 135 diabetic persons aged 70 years or older participating in the Coyoacán Cohort Study in Mexico City...
May 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28612915/how-to-predict-the-risk-of-postoperative-complications-after-coronary-artery-bypass-grafting-in-patients-under-50-and-over-80-years-old-a-retrospective-cross-sectional-study
#16
Jacek Piątek, Anna Kędziora, Grzegorz Kiełbasa, Marta Olszewska, Dorota Sobczyk, Bryan HyoChan Song, Janusz Konstanty-Kalandyk, Tomasz Darocha, Karol Wierzbicki, Irena Milaniak, Krzysztof Wróbel, Bogusław Kapelak
BACKGROUND: Coronary artery disease (CAD) remains the leading cause of death in developed countries and there is an increasing number of both young and elderly patients requiring surgical treatment. Despite improvement of conventional risk stratification scores (EuroSCORE II, STS risk score), all of the calculations are estimated based on the typical population and the studies emphasize that the scales may need further investigation and modernization, as demographic changes of the population suffering from CAD are unavoidable...
June 14, 2017: Kardiologia Polska
https://www.readbyqxmd.com/read/28610677/association-between-vitamin-d-status-and-asymmetric-dimethylarginine-adma-concentration-in-the-korean-elderly-population
#17
Hye Rin Choi, Seung Won Lee, Hyungseon Yeom, Da-Hye Jeon, Hyeon Chang Kim, Yoosik Youm
OBJECTIVES: Vitamin D deficiency has been reported to be associated with the risk of cardiovascular disease. We investigated the relationship between vitamin D status and asymmetric dimethylarginine (ADMA) concentration, a marker of endothelial dysfunction, in the Korean elderly population. STUDY DESIGN: A cross-sectional study was conducted on 269 men and 382 women (mean age, 71.6 years) enrolled in the Korean Social Life, Health, and Aging Project (KSHAP), a population-based longitudinal study of health determinants in elderly Koreans...
August 2017: Maturitas
https://www.readbyqxmd.com/read/28607863/immediate-regrafting-of-the-split-thickness-skin-graft-donor-site-assists-healing
#18
Brian P Bradow, Geoffrey G Hallock, Samuel P Wilcock
BACKGROUND: Delayed or even lack of healing of a split-thickness skin graft (STSG) donor site is a potential problem with elderly patients or those with poor wound healing capabilities. A proactive solution that may minimize this risk is to regraft that donor site using otherwise discarded skin graft remnants. METHODS: A prospective, nonrandomized, consecutive study was designed to compare the time to healing of the commonly used anterior thigh STSG donor site in patients who had routine dressings (n = 113) versus those with comorbidities known to adversely affect wound healing and had planned regrafting (n = 204)...
May 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28603515/factors-influencing-decision-making-for-carotid-endarterectomy-versus-stenting-in-the-very-elderly
#19
REVIEW
Sung Hyuk Heo, Cheryl D Bushnell
As the population ages worldwide, the number of elderly patients with carotid stenosis is also increasing. There have been many large clinical trials comparing carotid endarterectomy (CAE) versus stenting, but the inclusion criteria (i.e., symptomatic or asymptomatic), stenting methods (i.e., protection device), and primary end point (i.e., the definition of myocardial infarction and follow-up period) were different between trials. Therefore, the interpretation of those results is difficult and requires attention...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28600113/non-typhi-salmonella-enterica-urinary-tract-infections
#20
G Mellon, C Delanoe, A L Roux, B Heym, O Dubourg, P Hardy, B Chevallier, C Perronne, E Rouveix, J Salomon
OBJECTIVE: Non-typhi Salmonella enterica urinary tract infections (UTIs) are not frequent and rarely reported in the literature. We aimed to characterize clinical presentations and risk factors for the infection. PATIENTS AND METHODS: We performed a retrospective study of non-typhi Salmonella enterica strains isolated from urine cytobacteriological examinations (UCBE) collected between January 1, 1996 and October 30, 2014 and analyzed by the microbiology laboratories of the university hospitals of the western part of Île-de-France and of Paris, France...
June 6, 2017: Médecine et Maladies Infectieuses
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