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Diabetes in elderly

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https://www.readbyqxmd.com/read/28931126/cutaneous-mycobacterium-gordonae-infection-in-an-elderly-diabetic-returned-traveller
#1
Ibrahim Al-Busaidi, Daniel Wong, Andrea K Boggild
Mycobacterium gordonae, a low pathogenicity organism, is rarely implicated in skin and soft tissue infections. We present a 77-year-old returned diabetic traveler from rural Sudan with cutaneous M. gordonae infection. Several months of ciprofloxacin, rifampin and ethambutol led to resolution of his plaque, without signs of recurrence at 6-month follow-up.
September 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28926876/-advances-in-the-research-of-characteristics-and-treatment-of-burns-in-the-elderly
#2
R Liu, Z Y Li
With the development of society and the improvement of medical level, the average life span of human has been increasing year by year. The proportion of elderly burn patients is also increasing yearly, which has become a social problem that can not be ignored. Because of physiological characteristics, such as decreased function of heart, lung, and kidney, degenerative changes of neural system, reduced gastrointestinal function and immunological function, and mostly accompanied by primary diseases of diabetes and cardiovascular diseases, elderly burn patients suffer from high shock rate and mortality, and their wounds are not easy to heal...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28925048/the-association-between-insulin-resistance-metabolic-variables-and-depressive-symptoms-in-mexican-american-elderly-a-population-based-study
#3
Breno S Diniz, Susan Fisher-Hoch, Joseph McCormick
OBJECTIVE: Depressive symptoms are common among older adults with obesity and diabetes. Nonetheless, the mechanisms for this association are not clear but may involve changes in the insulin cascade signaling. We aimed to investigate the association, and potential mediators, between obesity, insulin resistance, and depressive symptoms among older adults from a homogenous cohort of Mexican-Americans. METHODS: We included a total of 500 Mexican-American older adults assessed in the Cameron County Health Study...
September 18, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28924128/igg4-related-hypophysitis-with-subtle-hypopituitarism-in-an-elderly-diabetic-patient-is-treatment-or-observation-preferable
#4
Motoki Kawasaki, Motoyoshi Tsujino, Fuminori Sato, Maya Sakurada, Kenji Nishida, Takayasu Kise, Yuko Hijioka, Mitsugu Ishizawa, Kazuaki Enatsu, Yoshihiro Ogawa
A 70-year-old man with diabetes mellitus presented with an enlarged pituitary stalk in 2014. IgG4-related parotitis and submandibular sialoadenitis were diagnosed in 2012. He denied any symptoms related to a pituitary mass. His visual field was intact, and his hypopituitarism was subtle. The serum IgG4 level was elevated. A lip biopsy revealed strong fibrosis and hyper-infiltration of IgG4-positive plasma cells. Based on these findings, IgG4-related hypophysitis was diagnosed. The patient was carefully followed without specific intervention...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28920861/pharmacotherapy-of-type-2-diabetes-an-update
#5
REVIEW
Jagriti Upadhyay, Stergios A Polyzos, Nikolaos Perakakis, Bindiya Thakkar, Stavroula A Paschou, Niki Katsiki, Patricia Underwood, Kyung-Hee Park, Jochen Seufert, Eun Seok Kang, Elliot Sternthal, Asterios Karagiannis, Christos S Mantzoros
Type 2 diabetes (T2DM) is a leading cause of morbidity and mortality worldwide and a major economic burden. The prevalence of T2DM is rising, suggesting more effective prevention and treatment strategies are necessary. The aim of this narrative review is to summarize the pharmacologic treatment options available for patients with T2DM. Each therapeutic class is presented in detail, outlining medication effects, side effects, glycemic control, effect on weight, indications and contraindications, and use in selected populations (heart failure, renal insufficiency, obesity and the elderly)...
September 8, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28918198/are-we-missing-hypoglycaemia-elderly-patients-with-insulin-treated-diabetes-present-to-primary-care-frequently-with-non-specific-symptoms-associated-with-hypoglycaemia
#6
Suzy V Hope, Phil J Taylor, Beverley M Shields, Andrew T Hattersley, Willie Hamilton
INTRODUCTION: We assessed if patients with known hypoglycaemia present on other occasions with non-specific symptoms associated with (but not diagnosed as) hypoglycaemia, potentially representing missed hypoglycaemia. METHODS: 335 primary care records (5/2/12-4/2/13) from patients aged >65 (79 on insulin, 85 on sulphonylureas, 121 on metformin only, 50 without diabetes) were assessed for hypoglycaemia episodes and consultations with non-specific symptoms, "hypo clues"...
September 11, 2017: Primary Care Diabetes
https://www.readbyqxmd.com/read/28917025/cardiac-rehabilitation-in-patients-who-underwent-primary-percutaneous-coronary-intervention-for-acute-myocardial-infarction-determinants-of-programme-participation-and-completion
#7
M Sunamura, N Ter Hoeve, M L Geleijnse, R V Steenaard, H J G van den Berg-Emons, H Boersma, R T van Domburg
BACKGROUND: Hospital length of stay after acute myocardial infarction (AMI) treated with primary percutaneous coronary intervention (pPCI) has reduced, resulting in more limited patient education during admission. Therefore, systematic participation in cardiac rehabilitation (CR) has become more essential. We aimed to identify patient-related factors that are associated with participation in and completion of a CR programme. METHODS: We identified 3,871 consecutive AMI patients who underwent pPCI between 2003 and 2011...
September 15, 2017: Netherlands Heart Journal
https://www.readbyqxmd.com/read/28915308/mutilating-purpura-fulminans-in-an-adult-with-meningococcal-sepsis
#8
María Elena Arnáiz-García, Ana María Arnáiz-García, Francisco Gutierrez-Diez, Juan Francisco Nistal, Jose María González-Santos, Ivana Pulitani, Carlos Amado-Diago, Javier Arnáiz
We report a dramatic case of meningococcal sepsis manifesting as purpura fulminans in an elderly diabetic woman. Hemodynamic instability and severe bilateral cutaneous lesions involving her hands and feet developed rapidly. Specific antibiotic therapy and the administration of inotropic and vasopressor drugs were initiated. The severity and extension of the cutaneous lesions (attributed to purpura fulminans) worsened because of the need for vasoconstrictors for the treatment of septic shock. Bilateral transmetatarsal and metacarpal amputations were required to stabilize the patient...
September 2017: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/28913629/atherogenic-index-of-plasma-is-positively-associated-with-the-risk-of-all-cause-death-in-elderly-women-a%C3%A2-10-year-follow-up
#9
Matej Bendzala, Peter Sabaka, Martin Caprnda, Andrea Komornikova, Maria Bisahova, Ruth Baneszova, Daniel Petrovic, Robert Prosecky, Luis Rodrigo, Peter Kruzliak, Andrej Dukat
BACKGROUND: The blood concentrations of total cholesterol and low-density lipoprotein (LDL) do not predict survival in patients older than 60 years. The atherogenic index of plasma (AIP) is a logarithm of the triacylglycerol to high-density lipoprotein (HDL) ratio and a surrogate for the concentration of small dense LDL. It might be a better reflection of the risk of all-cause death in elderly patients. METHODS: We conducted a prospective observational study of patients with arterial hypertension older than 60 years...
September 14, 2017: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/28911977/screening-for-sexual-dissatisfaction-among-people-with-type-2-diabetes-in-primary-care
#10
Anne Bijlsma-Rutte, Annemarie M J Braamse, Patricia van Oppen, Frank J Snoek, Paul Enzlin, Peter Leusink, Giel Nijpels, Petra J M Elders
AIMS: The identification and discussion of sexual care needs in people with type 2 diabetes mellitus (T2DM) in primary care is currently insufficient. The objective of this study was to determine the prevalence of sexual dissatisfaction, sexual problems and need for help by using a screening instrument among people with T2DM in primary care. METHODS: Data were collected in 45 general practices in the Netherlands from January 2015 to February 2016. The Brief Sexual Symptom Checklist (BSSC) was used to screen among 40-75 year old men and women...
August 4, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28910744/advanced-glycation-end-products-induced-il-6-and-vegf-a-production-and-apoptosis-in-osteocyte-like-mlo-y4-cells-by-activating-rage-and-erk1-2-p38-and-stat3-signalling-pathways
#11
Helin Chen, Wenjia Liu, Xiangnan Wu, Min Gou, Jiefei Shen, Hang Wang
Advanced glycation end products (AGEs) are involved in osteopenia in people with diabetes and the elderly. Interleukin-6 (IL-6) and vascular endothelial growth factor-A (VEGF-A) are potent regulators of bone metabolism, and in bone tissue, osteocytes are an important source of these regulators. However, whether AGEs can directly regulate IL-6 and VEGF-A secretion by osteocytes is unknown. In this study, we evaluated the effect of AGEs on IL-6 and VEGF- A production as well as apoptosis in osteocyte-like MLO-Y4 cells...
September 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28904260/impaired-%C3%AE-cell-function-and-decreased-insulin-sensitivity-in-subjects-with-normal-oral-glucose-tolerance-but-isolated-high-glycosylated-hemoglobin
#12
Qi Fu, Min Sun, Zhixiao Wang, Wei He, Yu Duan, Tao Yang
The pathophysiology is distinct in various state of glucose metabolism abnormalities. As the defect of individuals with normal oral glucose tolerance (NGT) but isolated high glycosylated hemoglobin (HbA1c), i.e. iHH, was ambiguous, we aimed to investigate the insulin sensitivity and β-cell function of iHH. According to the ADA criteria of HbA1c cut-off point (5.7%), 3,517 subjects with NGT screened from a total of 7,855 middle-aged and elderly Chinese without known diabetes were divided into two groups, 1,877 subjects with HbA1c < 5...
September 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28903724/resting-heart-rate-and-impaired-glucose-regulation-in-middle-aged-and-elderly-chinese-people-a-cross-sectional-analysis
#13
Zhen Yang, Weiwei Zhang, Lingfei Zhu, Ning Lin, Yixin Niu, Xiaoyong Li, Shuai Lu, Hongmei Zhang, Xuanchun Wang, Jie Wen, Guang Ning, Li Qin, Qing Su
BACKGROUND: Elevated resting heart rate (RHR) has been reported to be associated with metabolic syndrome and type 2 diabetes. The aim of this study was to explore whether a positive relationship exists between RHR and impaired glucose regulation (IGR) among middle-aged and older Chinese individuals. METHODS: We conducted a cross-sectional analysis that included a total of 9898 subjects (3194 men and 6704 women) in a Chinese population. The RHRs were derived from ECG recordings, and the subjects were stratified based on RHR quartiles...
September 13, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28902922/molecular-clustering-of-patients-with-diabetes-and-pulmonary-tuberculosis-a-systematic-review-and-meta-analysis
#14
Francles Blanco-Guillot, Guadalupe Delgado-Sánchez, Norma Mongua-Rodríguez, Pablo Cruz-Hervert, Leticia Ferreyra-Reyes, Elizabeth Ferreira-Guerrero, Mercedes Yanes-Lane, Rogelio Montero-Campos, Miriam Bobadilla-Del-Valle, Pedro Torres-González, Alfredo Ponce-de-León, José Sifuentes-Osornio, Lourdes Garcia-Garcia
INTRODUCTION: Many studies have explored the relationship between diabetes mellitus (DM) and tuberculosis (TB) demonstrating increased risk of TB among patients with DM and poor prognosis of patients suffering from the association of DM/TB. Owing to a paucity of studies addressing this question, it remains unclear whether patients with DM and TB are more likely than TB patients without DM to be grouped into molecular clusters defined according to the genotype of the infecting Mycobacterium tuberculosis bacillus...
2017: PloS One
https://www.readbyqxmd.com/read/28901796/efficacy-and-safety-of-saxagliptin-in-combination-with-insulin-in-japanese-patients-with-type-2-diabetes-mellitus-a-16-week-double-blind-randomized-controlled-trial-with-a-36-week-open-label-extension
#15
Takashi Kadowaki, Satsuki Muto, Yoshiumi Ouchi, Ryutaro Shimazaki, Yutaka Seino
BACKGROUND: We examined the efficacy and safety of saxagliptin as an add-on to insulin in Japanese patients with type 2 diabetes mellitus. RESEARCH DESIGN AND METHODS: We randomized 240 patients with type 2 diabetes mellitus on insulin monotherapy to 5-mg saxagliptin or placebo as add-on therapy for a 16-week, double-blind period. All patients received 5-mg saxagliptin and insulin for an additional 36 weeks (open-label extension). Change in hemoglobin A1c (HbA1c) at Week 16 was the main endpoint...
September 13, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28901251/case-report-severe-hematological-muscle-and-liver-toxicity-caused-by-drugs-and-artichoke-infusion-interaction-in-an-elderly-polymedicated-patient
#16
M G Campos, J Machado, M L Costa, S Lino, F Correia, F Maltez
Case report, in a patient with a history of diabetes and hypertension, treated with metformin, gliclazide, enalapril + hydrochlorothiazide, amlodipine, aspirin and diazepam, recently medicated for a gouty crisis with colchicine and clonixin without improvement. Believing it could help in the treatment of gouty crisis symptoms he took about 1.5 L of artichoke infusion (Cynara cardunculus). He felt better and did agriculture work but developed a distal muscle pain, severe anemia, standard biochemical liver cholestasis, increase of alkaline phosphatase and marked increase of inflammatory parameters (hyperleucocytosis) and enters in the emergency department at the hospital...
September 12, 2017: Current Drug Safety
https://www.readbyqxmd.com/read/28899681/comparative-degradomics-of-porcine-and-human-wound-exudates-unravels-biomarker-candidates-for-assessment-of-wound-healing-progression-in-trauma-patients
#17
Fabio Sabino, Fabian E Egli, Simonas Savickas, Jörg Holstein, Daniela Kaspar, Mika Rollmann, Jayachandran N Kizhakkedathu, Tim Pohlemann, Hans Smola, Ulrich Auf dem Keller
Impaired cutaneous wound healing is a major complication in elderly people and patients suffering from diabetes with raising rates in industrialized countries. Heterogeneity of clinical manifestations hampers effective molecular diagnostics and decisions for appropriate therapeutic regimens. Using a customized positional quantitative proteomics workflow, we have established a time-resolved proteome and N-terminome resource from wound exudates in a clinically relevant pig wound model that we exploited as robust template to interpret a heterogeneous dataset from patients undergoing the same wound treatment...
September 9, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28899347/case-report-of-hyperglycemic-nonketotic-chorea-with-rapid-radiological-resolution
#18
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: Hemichorea is a rare manifestation of nonketotic hyperglycemia that usually affects elderly Asian women with poor glycemic control. Non-contrast computerized Tomography and T1- weighted Magnetic Resonance Imaging shows characteristic hyperintense basal ganglia lesions. CASE PRESENTATION: A Fifty-seven year old Sri Lankan female presented with a two-day history of right upper limb chorea. She had been diagnosed with diabetes mellitus one year ago, but was not on any treatment and did not have any micro vascular or macro vascular complications...
September 12, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28894631/ethnopharmacological-survey-on-traditional-medicinal-plants-at-kalaroa-upazila-satkhira-district-khulna-division-bangladesh
#19
Oby Dulla, Farhana Israt Jahan
AIM: The traditional source of medicinal plants is an important way for daily curative uses in the rural area throughout Bangladesh. An ethnomedicinal survey was conducted in a randomized manner among traditional medicinal practitioners to find out about the medicinal plants of Kalaroa, Bangladesh. MATERIALS AND METHODS: The information was collected through conducting interviews, discussion, and field observations with herbal healers and knowledgeable elders of the study areas from November 01, 2015, to December 31, 2015, who pointed out various medicinal plants and described their uses, using semi-structured questionnaires...
July 2017: Journal of Intercultural Ethnopharmacology
https://www.readbyqxmd.com/read/28892959/prevalence-of-conventional-risk-factors-and-evaluation-of-baseline-indices-among-young-and-elderly-patients-with-coronary-artery-disease
#20
Arsalan Majeed Adam, Aiman Rehan, Nageen Waseem, Unzela Iqbal, Hira Saleem, Muhammad Armughan Ali, Ali Tariq Shaikh, Ansab Godil
INTRODUCTION: Coronary Artery Disease (CAD) is a leading cause of morbidity and mortality worldwide, manifesting in a variety of clinical spectrums such as an asymptomatic disease or acute coronary syndrome. It has become highly prevalent in Southeast Asia, including Pakistan. There has been little work done on the prevalence of traditional risk factors in different age groups and genders and there is a dire need to gauge the importance of baseline indices in CAD patients. AIM: To determine the prevalence of conventional risk factors and evaluate the variations in lipid profiles, electrolyte levels and haematological indices among patients with CAD in different age groups and gender...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
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