Read by QxMD icon Read

Diabetes in elderly

Jiadela Teliewubai, Bin Bai, Yiwu Zhou, Yuyan Lu, Shikai Yu, Chen Chi, Jue Li, Jacques Blacher, Yawei Xu, Yi Zhang
Objective: Secreted frizzled related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that is implicated in metabolic and cardiovascular disease (CVD). However, little is known about the relevance of SFRP5 with asymptomatic hypertensive target organ damages (TODs). We aimed to investigate the association between SFRP5 and TOD in a large population. Clinical trial registration: NCT02368938. Methods: A total of 1,745 community-dwelling elderly subjects aged over 65 years from northern Shanghai were recruited in the study...
2018: Clinical Interventions in Aging
Jae-Min Park, Jae-June Dong, Ji-Won Lee, Jae-Yong Shim, Yong-Jae Lee
BACKGROUND/AIMS: This study aimed to investigate the relationship between employment status and insulin resistance in the Korean elderly population. METHODS: The study included 2325 healthy participants (862 men and 1463 women) who did not have diabetes, were 60-74 years old, and participated in the 2007-2010 Korea National Health and Nutrition Examination Survey. Their employment status was categorized as employed or unemployed. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to assess insulin sensitivity...
March 16, 2018: Aging Clinical and Experimental Research
Su Mi Kim, Ho Geun Youn, Ji Yeong An, Yoon Young Choi, Sung Hoon Noh, Seung Jong Oh, Tae Sung Sohn, Sung Kim
PURPOSE: The purpose of this study was to estimate surgical outcomes of elderly patients older than 80 years who received laparoscopic or open gastrectomy for gastric cancer and to identify risk factors for postoperative complications. METHODS: Two hundred forty-two elderly patients older than 80 years underwent gastric cancer surgery between January 2010 and December 2016 in three tertiary hospitals. They were divided into two groups: laparoscopic gastrectomy (N = 59) and open gastrectomy (N = 183)...
March 16, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Martin M Grajower
Hypoglycemia is the major side effect of insulin therapy. The elderly are especially vulnerable to episodes of hypoglycemia, and with greater risks of complications such as falls. Two new long-acting basal insulins, glargine-300 (Gla-300) and degludec, are associated with lower incidences of hypoglycemia than previously available basal insulins. One of them, Gla-300, was studied in the elderly and has a lower incidence of hypoglycemia in patients over 65 years old. These new data should be incorporated into decision making when treating the elderly patient with insulin, whether they have type 1 or 2 diabetes...
March 2018: Endocrine Practice
Ayesha Fawad, Andreas Bergmann, Joachim Struck, Peter M Nilsson, Marju Orho-Melander, Olle Melander
Context: The gut hormone neurotensin promotes fat absorption, diet-induced weight gain and liver steatosis. Its stable precursor-hormone fragment "proneurotensin" predicts cardiometabolic disease in middle-aged populations, especially in women. Objective: To test if proneurotensin predicts cardiovascular disease (CVD) and diabetes development in an elderly population and whether there are gender differences in this respect. Design, Setting and Participants: Fasting proneurotensin was measured in plasma from 4804 participants (mean age 69±6 years) of the Malmö Preventive Project (MPP) and subjects were followed up for development of CVD and diabetes during 5...
March 13, 2018: Journal of Clinical Endocrinology and Metabolism
Lu Liu, Qiu Li, Zhongshang Yuan, Meng Zhao, Xu Zhang, Haiqing Zhang, Dongmei Zheng, Jin Xu, Ling Gao, Qingbo Guan, Jiajun Zhao, Christopher G Proud, Xuemin Wang, Xu Hou
AIMS/INTRODUCTION: Limited data are available regarding the performance of non-high-density lipoprotein cholesterol (non-HDL) in predicting incident diabetes. We aimed to analyze the association between non-HDL and development of diabetes, and to estimate the cut-off point of non-HDL for discriminating incident diabetes in people with normal glucose tolerance (NGT). MATERIALS AND METHODS: Of 3653 middle aged and elderly Chinese with NGT at enrollment, 1,025 men and 1,805 women returned to the 3-year follow-up and involved in the fianl analysis...
March 14, 2018: Journal of Diabetes Investigation
Líliam Barbosa Silva, Sônia Maria Soares, Patrícia Aparecida Barbosa Silva, Joseph Fabiano Guimarães Santos, Lívia Carvalho Viana Miranda, Raquel Melgaço Santos
OBJECTIVE: to evaluate the quality of care provided to older people with diabetes mellitus and/or hypertension in the Primary Health Care (PHC) according to the Chronic Care Model (CCM) and identify associations with care outcomes. METHOD: cross-sectional study involving 105 older people with diabetes mellitus and/or hypertension. The Patient Assessment of Chronic Illness Care (PACIC) questionnaire was used to evaluate the quality of care. The total score was compared with care outcomes that included biochemical parameters, body mass index, pressure levels and quality of life...
March 8, 2018: Revista Latino-americana de Enfermagem
Anna Karla de Oliveira Tito Borba, Ana Paula de Oliveira Marques, Vânia Pinheiro Ramos, Márcia Carrera Campos Leal, Ilma Kruze Grande de Arruda, Roberta Souza Pereira da Silva Ramos
This study aimed to investigate factors associated with the treatment adherence of 150 elderly diabetics assisted in gerontogeriatric outpatient service in northeastern Brazil. Full adherence to therapy was self-reported by 27.3% of the elderly. In the bivariate analysis, adherence was associated with self-perceived health, beliefs in the use of medication, understanding explanations about diabetes and professional responsible for treatment guidance. After analysis adjustment, only beliefs in medicine were significant when comparing non-adherence with full adherence (OR = 9...
March 2018: Ciência & Saúde Coletiva
Darlene Mara Dos Santos Tavares, Alisson Fernandes Bolina, Flavia Aparecida Dias, Pollyana Cristina Dos Santos Ferreira, Nilce Maria de Freitas Santos
This study aimed to verify the association of overweight with functional disability, self-reported morbidities and quality of life (QoL) among rural elderly dwellers. This is a domestic and cross-sectional survey conducted in the rural region of a municipality of Southeast Brazil. Three hundred seventy non-overweight elderly people and 192 overweight elderly people were evaluated with the following tools: semi-structured; Katz and Lawton and scales; World Health Organization Quality of Life - BREF and World Health Organization Quality of Life Assessment for Older Adults...
March 2018: Ciência & Saúde Coletiva
Erika Aparecida Silveira, Liana Lima Vieira, Jacqueline Danesio de Souza
Rapid population aging and abdominal obesity (AO) are worldwide public health problems among the elderly and have been insufficiently investigated. This article sets out to identify the prevalence of AO among the elderly, its association with different morbidities, sociodemographic variables, and lifestyle according to sex. It is a cross-sectional study with a representative sample of elderly people resident in Goiânia, Brazil. Home visits were conducted to measure weight, height, waist circumference (WC), blood pressure, and to fill out a standardized form...
March 2018: Ciência & Saúde Coletiva
Ronaldo Lira-Junior, Sigvard Åkerman, Björn Klinge, Elisabeth A Boström, Anders Gustafsson
BACKGROUND: Analysis of saliva is emerging as a promising tool to diagnose and monitor diseases which makes determination of the salivary microbial profile in different scenarios essential. OBJECTIVE: To evaluate the effects of age, periodontal disease, sex, smoking, and medical conditions on the salivary microbial profile. DESIGN: A randomly selected sample of 441 individuals was enrolled (51% women; mean age 48.5±16.8). Participants answered a health questionnaire and underwent an oral examination...
2018: PloS One
Steven Morrison, Karl M Newell
This study was designed to examine the effect of increasing age and type 2 diabetes on the average responses and inter- and intraindividual variability of falls risk, reaction time, strength, and walking speed for healthy older adults and older persons with type 2 diabetes (T2DM). Seventy-five older individuals (controls) and 75 persons with T2DM aged between 50 and 79 years participated in the study. Assessments of falls risk, reaction time (RT), knee extension strength, and walking speed were conducted. The results revealed that advancing age for both control and T2DM groups was reflected by a progressive increase in falls risk, decreased leg strength and a decline (i...
March 14, 2018: Journal of Motor Behavior
Shinsaku Imashuku, Miyako Kobayashi, Yoichi Nishii, Keisuke Nishimura
Diagnosis and treatment of Langerhans cell histiocytosis (LCH) in elderly patients are often difficult. We report here a 61-year-old female suffering from a refractory axillary ulcer for nearly a year, whose biopsy revealed LCH. It was also noted that the patient had other cutaneous papulovesicular eruptions of LCH as well as central diabetes insipidus. The patient was first successfully treated with multiagent chemotherapy (cytosine arabinoside/vinblastine/prednisolone). DDAVP also well controlled diabetes insipidus; however, the axillary ulcer and cutaneous LCH relapsed...
2018: Case Reports in Dermatological Medicine
Izabela Wróblewska, Iwona Zborowska, Anna Dąbek, Robert Susło, Zuzanna Wróblewska, Jarosław Drobnik
Background: The incidence of chronic diseases increases with age; about 73% of people who are aged ≥60 years suffer from at least 1 chronic disease, and among those older than 70 years, chronic diseases afflict more than >84% of the population. According to epidemiological data, at least 4 chronic disease types coexist in senior citizens, causing their disability. These are mainly cardiovascular diseases; motor system diseases; ophthalmological, auditory, neurological, and mental diseases; and mental impairment...
2018: Clinical Interventions in Aging
Ramesh Khadka, Wei Jun Tian, Hao Xin, Rakshya Koirala
To review literature addressing determination of the risk factor, early diagnosis and overall survival on outcome among patient of pancreatic cancer associated with diabetes mellitus from the perspective of pancreatic surgery. To identify recent guidelines, clinical pathogenesis, pathological classification, screening methodology and advances in surgical management. It identifies those clinical and surgical variables to predict excellent prognosis in respect of life style changes, ongoing advancement in therapeutic and surgical treatment and postoperative follow up...
March 10, 2018: International Journal of Surgery
L Li, Q Mo, T Mo, Y Liu, J L Tian, Z Wan
Objective: To investigate the clinical characteristics and pharmaceutical therapy of elderly patients with chronic heart failure (CHF). Methods: Using the multi-center retrospective cross-sectional survey, we analyzed 1 799 hospitalized patients with CHF as the main cause and NYHA heart function classification Ⅱ-Ⅳ from nine tertiary hospitals of Tianjin during March 2014 to February 2016. According to age, we divided them into non- elderly group(age<65 years), normal elderly group (age ≥65-79 years), and the old elderly group(age≥80 years)...
March 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Siti Khuzaimah Ahmad Sharoni, Hejar Abdul Rahman, Halimatus Sakdiah Minhat, Sazlina Shariff-Ghazali, Mohd Hanafi Azman Ong
BACKGROUND: Self-care behaviour is essential in preventing diabetes foot problems. This study aimed to evaluate the effectiveness of health education programs based on the self-efficacy theory on foot self-care behaviour for older adults with diabetes. METHODS: A randomised controlled trial was conducted for 12 weeks among older adults with diabetes in elderly care facility in Peninsular Malaysia. Six elderly care facility were randomly allocated by an independent person into two groups (intervention and control)...
2018: PloS One
Diego Z Carvalho, Erik K St Louis, David S Knopman, Bradley F Boeve, Val J Lowe, Rosebud O Roberts, Michelle M Mielke, Scott A Przybelski, Mary M Machulda, Ronald C Petersen, Clifford R Jack, Prashanthi Vemuri
Importance: Aging is associated with excessive daytime sleepiness (EDS), which has been linked to cognitive decline in the elderly. However, whether EDS is associated with the pathologic processes of Alzheimer disease remains unclear. Objective: To investigate whether EDS at baseline is associated with a longitudinal increase in regional β-amyloid (Aβ) accumulation in a cohort of elderly individuals without dementia. Design, Setting, and Participants: This prospective analysis included participants enrolled in the Mayo Clinic Study of Aging, a longitudinal population-based study in Olmsted County, Minnesota...
March 12, 2018: JAMA Neurology
Junichi Hoshino, Takayuki Hamano, Masanori Abe, Takeshi Hasegawa, Atsushi Wada, Yoshifumi Ubara, Kenmei Takaichi, Masaaki Inaba, Shigeru Nakai, Ikuto Masakane
Background: For glycemic control in diabetic patients on dialysis it was unclear what level of glycated albumin (GA) was associated with the lowest mortality and GA's utility. Accordingly, we examined the difference in association between GA and hemoglobin A1c (HbA1c) with 1-year mortality in a cohort of the Japanese Society for Dialysis Therapy. Methods: We examined 84 282 patients with prevalent diabetes who were on maintenance hemodialysis (HD) (female 30.3%; mean age 67...
March 8, 2018: Nephrology, Dialysis, Transplantation
David A Scott, Lisbeth Evered, Paul Maruff, Andrew MacIsaac, Sarah Maher, Brendan S Silbert
BACKGROUND: Hospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization (LHC) before the procedure and the incidence of cognitive decline to 3 months afterwards. METHODS AND RESULTS: We conducted a prospective, observational, clinical investigation of elderly participants undergoing elective LHC. Cognition was assessed using a battery of written tests and a computerized cognitive battery before the LHC and then at 3 months afterwards...
March 10, 2018: Journal of the American Heart Association
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"