keyword
https://read.qxmd.com/read/38533418/association-between-spo-2-and-the-risk-of-death-in-elderly-t2dm-patients-with-cerebral-infarction-a-retrospective-cohort-study
#1
JOURNAL ARTICLE
Shuo Zhang, Jiaqi Ji, Siqi Gao, Shu Yang, Zeyi Song, Jianmin Li, Junjie Liu
OBJECTIVE: This study aimed to evaluate the SpO2 (transcutaneous oxygen saturation) -mortality link in elderly T2DM (diabetes mellitus type 2) patients with cerebral infarction and identify their optimal SpO2 range. METHODS: In this investigation, we employed a comprehensive approach. Initially, we screened the MIMIC-IV database, identifying elderly T2DM patients with cerebral infarction, utilizing specific ICD-9 and ICD-10 codes. We then harnessed the power of restricted cubic splines to craft a visual representation of the correlation between SpO2 and 1-year mortality...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38533285/the-hidden-battle-within-shedding-light-on-the-co-existence-of-sarcopenia-and-sarcopenic-obesity-among-participants-with-type-2-diabetes-in-a-tertiary-care-hospital-gujarat
#2
JOURNAL ARTICLE
M Yogesh, Mansi Mody, Naresh Makwana, Samarth Rabadiya, Jenish Patel, Samyak Shah
INTRODUCTION: Type 2 diabetes (T2DM) is characterised by chronic hyperglycaemia due to abnormal insulin secretion and/or utilisation. Currently, sarcopenia has emerged as a new complication of T2DM, which increases the risk of physical disability, and even death. The study aims to estimate the prevalence of sarcopenia and sarcopenic obesity (SO) as well as their association with various other factors related to T2DM. METHODS: The study was an observational hospital-based cross-sectional study conducted among diabetic patients who came to the non-communicable diseases (NCD) clinic of a tertiary care hospital in Gujarat, India, from April 2023 to June 2023...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38531890/highlighting-the-effects-of-high-intensity-interval-training-on-the-changes-associated-with-hypertrophy-apoptosis-and-histological-proteins-of-the-heart-of-old-rats-with-type-2-diabetes
#3
JOURNAL ARTICLE
Mohammad Rami, Amirhossein Ahmadi Hekmatikar, Samaneh Rahdar, Sayed Shafa Marashi, D Maryama Awang Daud
T2DM is known to cause disturbances in glucose homeostasis and negative changes in the heart muscle, while aging and diabetes are recognized risk factors for CVD. Given this, our study aims to investigate a method for controlling and managing CVDs induced by T2DM in elderly populations. To achieve this, we categorized 40 rats into 5 groups, including HAD (n = 8), HA (n = 8), AD (n = 8), AHT (n = 8), and ADT (n = 8). The exercise protocol consisted of eight weeks of HIIT (three sessions per week) performed at 90-95% of maximal speed...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38528197/calcium-polystyrene-sulfonate-induced-rectal-ulcer-causing-e-coli-native-valve-infective-endocarditis
#4
JOURNAL ARTICLE
Shinnosuke Fukushima, Hideharu Hagiya, Hiroyuki Honda, Tomoharu Ishida, Ryohei Shoji, Kou Hasegawa, Fumio Otsuka
Escherichia coli-associated native-valve infective endocarditis is a rare disease that affects elderly patients with underlying risk factors such as diabetes mellitus, malignancy, and renal failure. Long-term use of calcium polystyrene sulfonate is a potential risk factor for gastrointestinal mucosal damage or even colorectal ulcers. Herein, we describe a fatal case of a 66-year-old Japanese man with diabetes mellitus and renal failure who was prescribed calcium polystyrene sulfonate (CPS) for 11 years and developed a CPS-induced rectal ulcer, leading to E...
March 25, 2024: Clinical Journal of Gastroenterology
https://read.qxmd.com/read/38525744/tirzepatide-and-glycemic-control-metrics-using-continuous-glucose-monitoring-in-older-patients-with-type-2-diabetes-mellitus-an-observational-pilot-study
#5
Takuya Omura, Akemi Inami, Taiki Sugimoto, Shuji Kawashima, Takashi Sakurai, Haruhiko Tokuda
This observational pilot study aimed to investigate continuous glucose monitoring (CGM) metrics in older Japanese patients with type 2 diabetes mellitus (T2DM) using a CGM system (FreeStyle Libre Pro) during the first tirzepatide administration and compare the glycemic control measures before and after the initial injection. The four patients had a mean age of 79.5 years (standard deviation [SD]: 5.8), a mean body mass index of 24.6 kg/m2 (SD: 4.7), a mean glycated hemoglobin level of 9.1% (SD: 2.1), and a mean measurement period of 10...
February 26, 2024: Geriatrics
https://read.qxmd.com/read/38524931/glycemic-control-and-dementia-risk-in-patients-aged-above-and-below-75-years
#6
JOURNAL ARTICLE
Hae Hyuk Jung
BACKGROUND: There is a lack of data about the treatment effect of glycemic control on incident dementia in patients with advanced age. METHODS: In a nationwide Korean cohort of 79,076 diabetic patients 75 years or older and a representative cohort of 74,672 diabetics aged 50 to 74 years, multivariable-adjusted incidence of overt dementia was estimated across yearly-averaged on-treatment fasting blood glucose (FBG) levels. RESULTS: During 9-year follow-up, overt dementia was noted in 24,710 (31...
April 2024: Diabetology International
https://read.qxmd.com/read/38524154/adapted-diabetes-complications-severity-index-predicts-dementia-risk-in-ageing-type-2-diabetes-mellitus-patients
#7
JOURNAL ARTICLE
Mingyang Sun, Wan-Ming Chen, Szu-Yuan Wu, Jiaqiang Zhang
This study investigated the link between the adapted diabetes complication severity index at the time of type 2 diabetes mellitus diagnosis and diabetes-induced dementia risk in elderly patients. Elderly type 2 diabetes mellitus patients (age ≥ 60) were matched using propensity score matching. Cox regression was used to determine dementia hazard ratios; Kaplan-Meier method to assess cumulative incidence. The cohort included 256 214 elderly type 2 diabetes mellitus patients. Adapted diabetes complication severity index ≥ 1 showed higher dementia risk (adjusted hazard ratio: 1...
2024: Brain communications
https://read.qxmd.com/read/38524052/effect-of-low-dose-aspirin-on-the-elderly
#8
REVIEW
Ali Darraj
Aspirin is a recognized and affordable antiplatelet medicine. Low amounts of aspirin have been used to prevent cardiovascular events, and it is still widely used for primary and secondary stroke prevention. The purpose of this review article is to evaluate the effects of using low doses of aspirin among elderly people. Although taking large dosages of aspirin (500 mg daily) reduces the long-term risk of colorectal cancer, its effectiveness for long-term prevention may be limited by adverse effects. Studies have assessed the relationship between aspirin dosage, incidence, and death in patients with colorectal cancer...
February 2024: Curēus
https://read.qxmd.com/read/38522145/nutrition-of-aging-people-with-diabetes-mellitus-focus-on-sarcopenia
#9
REVIEW
Almog Shalit, Eleni Gerontiti, Georgios Boutzios, Eleni Korakianiti, Fotini Kanouta, Vasiliki Vasileiou, Theodora Psaltopoulou, Stavroula A Paschou
As populations age, chronic diseases accumulate, and new health conditions emerge. One noteworthy pair that warrants further evaluation is diabetes mellitus and sarcopenia, given that the latter occurs in 28 % of the population aged over 50 who have diabetes mellitus. The management of both entails nutritional interventions, making the development of unified dietary recommendations an alluring strategy. This review aims to elucidate the current recommendations for the combined management of sarcopenia and diabetes, while featuring elements that require further research...
March 21, 2024: Maturitas
https://read.qxmd.com/read/38520638/prediction-model-for-mild-cognitive-impairment-in-patients-with-type-2-diabetes-using-the-autonomic-function-test
#10
JOURNAL ARTICLE
Heeyoung Kang, Juhyeon Kim, Minkyeong Kim, Jin Hyun Kim, Gu Seob Roh, Soo Kyoung Kim
OBJECTIVE: Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive impairment, and reduced heart rate variability (HRV) has been correlated with cognitive impairment in elderly individuals. This study investigated risk factors and validated a predictive model for mild cognitive impairment (MCI) in patients with T2DM using an autonomic function test. METHODS: Patients with T2DM, 50-85 years of age, who attended the diabetes clinic at Gyeongsang National University Hospital between March 2018 and December 2019, were included...
March 23, 2024: Neurological Sciences
https://read.qxmd.com/read/38520603/validity-of-montreal-cognitive-assessment-to-detect-cognitive-impairment-in-individuals-with-type-2-diabetes
#11
JOURNAL ARTICLE
Anu Gupta, Alpesh Goyal, Roopa Rajan, Venugopalan Y Vishnu, Mani Kalaivani, Nikhil Tandon, Madakasira V P Srivastava, Yashdeep Gupta
INTRODUCTION: Guidelines recommend screening older people (> 60-65 years) with type 2 diabetes (T2D) for cognitive impairment, as it has implications in the management of diabetes. The Montreal Cognitive Assessment (MoCA) is a sensitive test for the detection of mild cognitive impairment (MCI) in the general population, but its validity in T2D has not been established. METHODS: We administered MoCA to patients with T2D (age ≥ 60 years) and controls (no T2D), along with a culturally validated neuropsychological battery and functional activity questionnaire...
March 23, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38519973/combined-impact-of-alcohol-consumption-and-metabolic-syndrome-on-liver-dysfunction-in-an-elderly-chinese-population
#12
JOURNAL ARTICLE
Yanrong Zhao, Xiaoxue Yuan, Tianxiang Lin, Qing Yang, Xuewen Jiang, Song Yang, Yinwei Qiu
Alcohol consumption and metabolic syndrome(MetS), both prevalent in the general population, frequently co-occur. They are recognized as significant contributors to liver dysfunction, yet their combined effect is often challenging to delineate. This study delves into the compounding influence of alcohol consumption and metabolic disorder on liver dysfunction within an elderly demographic in Zhejiang Province, China. Our findings spotlight a heightened risk of liver dysfunction among females, younger individuals, rural dwellers, those with minimal educational attainment, single individuals, and those diagnosed with MetS...
March 23, 2024: Diabetology & Metabolic Syndrome
https://read.qxmd.com/read/38516544/management-and-outcomes-of-necrotizing-otitis-externa-a-retrospective-cohort-study-in-a-tertiary-referral-center
#13
JOURNAL ARTICLE
Eleonora G M Vosbeek, Louise V Straatman, Arthur J A T Braat, Bart de Keizer, Hans G X M Thomeer, Adriana L Smit
OBJECTIVES: Necrotizing otitis externa (NOE) is a rare infection of the ear that causes osteomyelitis. We aimed to evaluate treatment outcomes and the role of imaging in diagnosing and monitoring disease resolution in a single-center study of patients with NOE. METHODS: In this retrospective cohort study, patients with NOE who were diagnosed and treated in a tertiary otology center in Utrecht, The Netherlands, between January 1, 2013 and August 1, 2022, were included...
December 2023: Otol Neurotol Open
https://read.qxmd.com/read/38515515/assessing-interstitial-fluid-dynamics-in-type-2-diabetes-mellitus-and-prediabetes-cases-through-diffusion-tensor-imaging-analysis-along-the-perivascular-space
#14
JOURNAL ARTICLE
Rukeye Tuerxun, Koji Kamagata, Yuya Saito, Christina Andica, Kaito Takabayashi, Wataru Uchida, Seina Yoshida, Junko Kikuta, Hiroki Tabata, Hitoshi Naito, Yuki Someya, Hideyoshi Kaga, Mari Miyata, Toshiaki Akashi, Akihiko Wada, Toshiaki Taoka, Shinji Naganawa, Yoshifumi Tamura, Hirotaka Watada, Ryuzo Kawamori, Shigeki Aoki
BACKGROUND AND PURPOSE: Glymphatic system in type 2 diabetes mellitus (T2DM) but not in the prodrome, prediabetes (Pre-DM) was investigated using diffusion tensor image analysis along the perivascular space (DTI-ALPS). Association between glymphatic system and insulin resistance of prominent characteristic in T2DM and Pre-DM between is yet elucidated. Therefore, this study delves into the interstitial fluid dynamics using the DTI-ALPS in both Pre-DM and T2DM and association with insulin resistance...
2024: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/38515201/interactive-virtual-assistance-for-mental-health-promotion-and-self-care-management-in-elderly-with-type-2-diabetes-ivam-ed-study-protocol-and-statistical-analysis-plan-for-a-randomized-controlled-trial
#15
JOURNAL ARTICLE
Frederico Ludwig da Costa, Lucas Strassburger Matzenbacher, Vicenzo Gheno, Maria Antônia Bertuzzo Brum, Laura Gomes Boabaid de Barros, Isabela Semmelmann Maia, Luiza Machado Blank, Lucas Friedrich Fontoura, Janine Alessi, Gabriela Heiden Telo
BACKGROUND: With one in five individuals aged 65 or older living with type 2 diabetes worldwide, it is crucial to acknowledge and address the challenges faced by this population. In this context, our study aims to evaluate the efficacy of a behavioral intervention model delivered through a smart speaker on mental health and diabetes self-care in the elderly with diabetes. METHODS: This is a single-center, pragmatic, parallel two-arm open randomized clinical trial involving elderly patients with type 2 diabetes...
March 21, 2024: Trials
https://read.qxmd.com/read/38513745/maf-5-predicts-liver-fibrosis-risk-and-outcome-in-the-general-population-with-metabolic-dysfunction
#16
JOURNAL ARTICLE
Laurens A van Kleef, Sven M Francque, Jhon E Prieto-Ortiz, Milan J Sonneveld, Carlos B Sanchez-Luque, Robin G Prieto-Ortiz, Wilhelmus J Kwanten, Luisa Vonghia, An Verrijken, Christophe De Block, Zouhir Gadi, Harry L A Janssen, Robert J de Knegt, Willem P Brouwer
BACKGROUND & AIMS: There is an unmet need for non-invasive tests to improve case-finding and aid primary care professionals in referring patients at high risk of liver disease. METHODS: A metabolic dysfunction-associated fibrosis (MAF-5) score was developed and externally validated in a total of 21,797 individuals with metabolic dysfunction, in population-based (NHANES2017-2020, NHANESIII, Rotterdam Study) as well as hospital-based cohorts (from Antwerp and Bogota)...
March 19, 2024: Gastroenterology
https://read.qxmd.com/read/38510951/longitudinal-association-of-premature-atrial-contractions-with-atrial-fibrillation-and-brain-ischemia-in-people-with-type-2-diabetes-the-hoorn-diabetes-care-system-cohort
#17
JOURNAL ARTICLE
Peter P Harms, Jelle C L Himmelreich, Marieke T Blom, Joline W J Beulens, Giel Nijpels, Petra Elders, Wim A M Lucassen
BACKGROUND: Premature atrial contractions (PACs) are potential markers for imminent onset of both atrial fibrillation (AF) and brain ischemia (BI; transient ischemic attack [TIA] or ischemic stroke). We investigated the association of PACs with incident AF and BI events separately, and of incident AF with BI events in people with type 2 diabetes (T2D) without pre-existing AF or cerebrovascular disease. METHODS: A prospective longitudinal study of 12,242 people with T2D without known AF or cerebrovascular disease from the Hoorn Diabetes Care System cohort...
October 2023: American heart journal plus: cardiology research and practice
https://read.qxmd.com/read/38510703/multi-omics-subgroups-associated-with-glycaemic-deterioration-in-type-2-diabetes-an-imi-rhapsody-study
#18
JOURNAL ARTICLE
Shiying Li, Iulian Dragan, Van Du T Tran, Chun Ho Fung, Dmitry Kuznetsov, Michael K Hansen, Joline W J Beulens, Leen M 't Hart, Roderick C Slieker, Louise A Donnelly, Mathias J Gerl, Christian Klose, Florence Mehl, Kai Simons, Petra J M Elders, Ewan R Pearson, Guy A Rutter, Mark Ibberson
INTRODUCTION: Type 2 diabetes (T2D) onset, progression and outcomes differ substantially between individuals. Multi-omics analyses may allow a deeper understanding of these differences and ultimately facilitate personalised treatments. Here, in an unsupervised "bottom-up" approach, we attempt to group T2D patients based solely on -omics data generated from plasma. METHODS: Circulating plasma lipidomic and proteomic data from two independent clinical cohorts, Hoorn Diabetes Care System (DCS) and Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS), were analysed using Similarity Network Fusion...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38510656/mechanism-of-traditional-chinese-medicine-in-elderly-diabetes-mellitus-and-a-systematic-review-of-its-clinical-application
#19
REVIEW
Qiqi Zhang, Shiwan Hu, Zishan Jin, Sicheng Wang, Boxun Zhang, Linhua Zhao
Objective: Affected by aging, the elderly diabetes patients have many pathological characteristics different from the young people, including more complications, vascular aging, cognitive impairment, osteoporosis, and sarcopenia. This article will explore their pathogenesis and the mechanism of Traditional Chinese medicine (TCM) intervention, and use the method of systematic review to evaluate the clinical application of TCM in elderly diabetes. Method: Searching for randomized controlled trials (RCTs) published from January 2000 to November 2023 in the following databases: Web of Science, Pubmed, Embase, Cochrane Library, Sinomed, China National Knowledge Internet, Wanfang and VIP...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38509766/frailty-in-clinical-drug-trials-frailty-assessments-subgroup-analyses-and-outcomes
#20
REVIEW
Tu N Nguyen, Fahed Ahmad, Richard I Lindley
With population ageing, drug trials are increasingly turning their attention to including older, frailer people. This review aimed to provide an overview of how frailty was assessed in published studies related to clinical pharmacological trials, and on the interaction of frailty on the efficacy of the treatments. We searched MEDLINE, EMBASE and Cochrane for clinical drug trials in older people. A total of 4031 abstracts were screened and 17 relevant studies were included in this review. We summarized the findings of these 17 trials into five main clinical areas: cardiovascular (eight studies), cognition (one study), vaccination (two studies), cancer (four studies) and other (two studies)...
March 21, 2024: British Journal of Clinical Pharmacology
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