keyword
https://read.qxmd.com/read/36905760/plasminogen-decreases-a%C3%AE-42-and-tau-deposition-and-shows-multi-beneficial-effects-on-alzheimer-s-disease-in-mice-and-humans
#21
JOURNAL ARTICLE
Chunying Guo, Ting Wang, Dongmei Zhang, Xiaojing Ge, Jinan Li
Alzheimer's disease (AD) is the most common neurodegenerative disorder in the world. The aggregation of both amyloid beta (Aβ) peptides extracellularly and Tau proteins intracellularly plays key roles in the pathological consequences of AD, which lead to cholinergic neurodegeneration and eventually death. Currently, there are no effective methods to stop the progression of AD. Using ex vivo, in vivo and clinical approaches, we investigated the functional effects of plasminogen on the widely used FAD, Aβ42 oligomer or Tau intracranial injection-induced AD mouse model and explored its therapeutic effects on patients with AD...
April 30, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/36834612/the-nerve-growth-factor-receptor-ngfr-p75-ntr-a-major-player-in-alzheimer-s-disease
#22
REVIEW
Francesco Bruno, Paolo Abondio, Alberto Montesanto, Donata Luiselli, Amalia C Bruni, Raffaele Maletta
Alzheimer's disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space ( amyloid plaques ) and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; tangles or neurofibrillary aggregates ). The Nerve growth factor receptor (NGFR/p75NTR ) represents a low-affinity receptor for all known mammalians neurotrophins (i...
February 6, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36402237/stimulation-of-functional-recovery-via-neurorepair-mechanisms-by-the-traditional-japanese-kampo-medicine-ninjin-yoeito-and-physical-exercise-in-a-rat-ischemic-stroke-model
#23
JOURNAL ARTICLE
Akira Tani, Harutoshi Sakakima, Shotaro Otsuka, Keita Mizuno, Kazuki Nakanishi, Kosuke Norimatsu, Seiya Takada, Teruki Matsuoka, Ryoma Matsuzaki, Tomomi Nakakogawa, Ikuro Maruyama
ETHNOPHARMACOLOGICAL RELEVANCE: Ninjin'yoeito (NYT), a traditional Japanese Kampo medicine consisting of 12 herbs, has been reported to improve cognitive dysfunction, depression, and neurological recovery in patients with neurovascular diseases such as Alzheimer's disease and stroke. Several studies have reported that the NYT components exert neurotrophic, neurogenic, and neuroprotective effects. In addition, exercise enhances neuroprotection and functional recovery after stroke. Rehabilitative exercises and pharmacological agents induce neurophysiological plasticity, leading to functional recovery in stroke patients...
November 16, 2022: Journal of Ethnopharmacology
https://read.qxmd.com/read/36369435/differentially-expressed-long-noncoding-rnas-and-mrnas-in-pc12-cells-under-lysophosphatidylcholine-stimulation
#24
JOURNAL ARTICLE
Wen Zhang, Su Dun, Yin Ping, Qingliang Wang, Siqin Tana, Aodong Tana, Si Qin, Xilinqiqige Bao, Alateng Qimuge, Tegexi Baiyin, Dezhi Yang, Siqin Bao, Seyin Baoyin, Wuhan Qimuge
Lysophosphatidylcholine (LPC) was previously found to show neuroprotective effect on nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) induced signalings. Also, numerous studies reported the emerging roles of long noncoding RNAs (LncRNAs) involved in neurodegenerative disease. However, the biological mechanism of LPC and expression profile of lncRNAs has not been reported. Here, lncRNAs in PC12 cells under LPC and NGF treatment were analyzed using high throughput sequencing technology for the first time...
November 11, 2022: Scientific Reports
https://read.qxmd.com/read/36362380/neurotrophic-and-immunomodulatory-lanostane-triterpenoids-from-wood-inhabiting-basidiomycota
#25
JOURNAL ARTICLE
Khadija Hassan, Blondelle Matio Kemkuignou, Marco Kirchenwitz, Kathrin Wittstein, Monique Rascher-Albaghdadi, Clara Chepkirui, Josphat C Matasyoh, Cony Decock, Reinhard W Köster, Theresia E B Stradal, Marc Stadler
Neurotrophins such as nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) play important roles in the central nervous system. They are potential therapeutic drugs for the treatment of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. In this study, we investigated the neurotrophic properties of triterpenes isolated from fruiting bodies of Laetiporus sulphureus and a mycelial culture of Antrodia sp. MUCL 56049. The structures of the isolated compounds were elucidated based on nuclear magnetic resonance (NMR) spectroscopy in combination with high-resolution electrospray mass spectrometry (HR-ESIMS)...
November 6, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36342585/effects-of-subchronic-aluminum-exposure-on-learning-memory-and-neurotrophic-factors-in-rats
#26
JOURNAL ARTICLE
Wei Liu, Jiaxi Liu, Jie Gao, Xiaoxu Duan, Lifeng Zhang
Aluminum (Al) is a neurotoxin that gradually accumulates in the brain in human life, resulting in oxidative brain injury related to Alzheimer's disease (AD) and other diseases. In this study, the learning and memory of rats exposed to different aluminum concentrations (0.0 g/L, 2.0 g/L, 4.0 g/L, and 8.0 g/L) were studied, and the learning and memory of rats were observed by shuttle box experiment. With hematoxylin and eosin staining, Western blot, immunofluorescence, and RT-PCR, the morphology of nerve cells in the hippocampus of rat brain were observed, and the levels of activator protein-1 (AP-1) gene and protein, nerve growth factor (NGF), neurotrophin-3 (NT3), glial cell line-derived neurotrophic factor (GDNF), and brain-derived neurotrophic factor (BDNF) gene and protein level, etc...
November 7, 2022: Neurotoxicity Research
https://read.qxmd.com/read/36284170/glial-cell-reactivity-and-oxidative-stress-prevention-in-alzheimer-s-disease-mice-model-by-an-optimized-nmda-receptor-antagonist
#27
JOURNAL ARTICLE
Júlia Companys-Alemany, Andreea L Turcu, Santiago Vázquez, Mercè Pallàs, Christian Griñán-Ferré
In Alzheimer's disease pathology, several neuronal processes are dysregulated by excitotoxicity including neuroinflammation and oxidative stress (OS). New therapeutic agents capable of modulating such processes are needed to foster neuroprotection. Here, the effect of an optimised NMDA receptor antagonist, UB-ALT-EV and memantine, as a gold standard, have been evaluated in 5XFAD mice. Following treatment with UB-ALT-EV, nor memantine, changes in the calcineurin (CaN)/NFAT pathway were detected. UB-ALT-EV increased neurotropic factors (Bdnf, Vgf and Ngf) gene expression...
October 25, 2022: Scientific Reports
https://read.qxmd.com/read/35921478/long-term-nucleus-basalis-cholinergic-depletion-induces-attentional-deficits-and-impacts-cortical-neurons-and-bdnf-levels-without-affecting-the-ngf-synthesis
#28
JOURNAL ARTICLE
Chiara Orciani, Hélène Hall, Rowan Pentz, Morgan K Foret, Sonia Do Carmo, Augusto Claudio Cuello
Basal forebrain cholinergic neurons (BFCNs) represent the main source of cholinergic innervation to the cortex and hippocampus and degenerate early in Alzheimer's disease (AD) progression. Phenotypic maintenance of BFCNs depends on levels of mature nerve growth factor (mNGF) and mature brain-derived neurotrophic factor (mBDNF), produced by target neurons and retrogradely transported to the cell body. Whether a reciprocal interaction where BFCN inputs impact neurotrophin availability and affect cortical neuronal markers remains unknown...
August 3, 2022: Journal of Neurochemistry
https://read.qxmd.com/read/35909451/neurotrophin-crosstalk-in-the-etiology-and-treatment-of-neuropsychiatric-and-neurodegenerative-disease
#29
REVIEW
Rajeev Joshi, Stephen R J Salton
This article reviews the current progress in our understanding of the mechanisms by which growth factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF), and select neurotrophin-regulated gene products, such as VGF (non-acronymic) and VGF-derived neuropeptides, function in the central nervous system (CNS) to modulate neuropsychiatric and neurodegenerative disorders, with a discussion of the possible therapeutic applications of these growth factors to major depressive disorder (MDD) and Alzheimer's disease (AD)...
2022: Frontiers in Molecular Neuroscience
https://read.qxmd.com/read/35850433/neurotrophin-targeted-therapeutics-a-gateway-to-cognition-and-more
#30
REVIEW
Gunnar Nordvall, Pontus Forsell, Johan Sandin
Neurotrophins, such as brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF), are small proteins expressed in the brain and peripheral tissues, which regulate several key aspects of neuronal function, including neurogenesis, synaptic plasticity and neuroprotection, but also programmed cell death. This broad range of effects is a result of a complex downstream signaling pathway, with differential spatial and temporal activation patterns further diversifying their physiological effects. Alterations in neurotrophin levels, or known polymorphisms in neurotrophin genes, have been linked to a variety of disorders, including depression and Alzheimer's disease (AD)...
July 16, 2022: Drug Discovery Today
https://read.qxmd.com/read/35732627/the-evolution-of-bdnf-is-defined-by-strict-purifying-selection-and-prodomain-spatial-coevolution-but-what-does-it-mean-for-human-brain-disease
#31
JOURNAL ARTICLE
Alexander G Lucaci, Michael J Notaras, Sergei L Kosakovsky Pond, Dilek Colak
Brain-Derived Neurotrophic Factor (BDNF) is an essential mediator of brain assembly, development, and maturation. BDNF has been implicated in a variety of brain disorders such as neurodevelopmental disorders (e.g., autism spectrum disorder), neuropsychiatric disorders (e.g., anxiety, depression, PTSD, and schizophrenia), and various neurodegenerative disorders (e.g., Parkinson's, Alzheimer's, etc.). To better understand the role of BDNF in disease, we sought to define the evolution of BDNF within Mammalia. We conducted sequence alignment and phylogenetic reconstruction of BDNF across a diverse selection of >160 mammalian species spanning ~177 million years of evolution...
June 22, 2022: Translational Psychiatry
https://read.qxmd.com/read/35625880/brain-derived-neurotropic-factor-in-neurodegenerative-disorders
#32
REVIEW
Abdallah Mohammad Ibrahim, Lalita Chauhan, Aditi Bhardwaj, Anjali Sharma, Faizana Fayaz, Bhumika Kumar, Mohamed Alhashmi, Noora AlHajri, Md Sabir Alam, Faheem Hyder Pottoo
Globally, neurodegenerative diseases cause a significant degree of disability and distress. Brain-derived neurotrophic factor (BDNF), primarily found in the brain, has a substantial role in the development and maintenance of various nerve roles and is associated with the family of neurotrophins, including neuronal growth factor (NGF), neurotrophin-3 (NT-3) and neurotrophin-4/5 (NT-4/5). BDNF has affinity with tropomyosin receptor kinase B (TrKB), which is found in the brain in large amounts and is expressed in several cells...
May 16, 2022: Biomedicines
https://read.qxmd.com/read/35607505/vrt-043198-ameliorates-surgery-induced-neurocognitive-disorders-by-restoring-the-ngf-and-bndf-expression-in-aged-mice
#33
JOURNAL ARTICLE
Qi Tang, Qiang Guo, Ke Li, Fan Fei
Background: Perioperative neurocognitive disorders (PND) are common surgical complications in the elderly. Pyroptosis-associated inflammation has been suggested to participate in a series of neurocognitive diseases, including Alzheimer's disease. Given that VRT-043198 can reportedly inhibit caspase-1-induced pyroptosis, this study sought to determine whether VRT-043198 reduced PND in a mouse model following abdominal exploratory laparotomy. Methods: 20-month-old male C57/BL mice were used to establish an abdominal exploratory laparotomy (AEL) model of PND...
2022: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/35516456/effects-of-pramipexole-combined-with-nerve-growth-factor-on-cognitive-impairment-and-urinary-ad7c-ntp-expression-in-patients-with-parkinson-s-disease
#34
JOURNAL ARTICLE
Zhengxin Wang, Saiyu Cheng
Objective: To explore the effects of pramipexole combined with nerve growth factor (NGF) on cognitive impairment and urinary Alzheimer-associated neural thread protein (AD7c-NTP) expression in patients with Parkinson's disease (PD). Methods: Fifty patients with PD treated in our hospital from February 2020 to April 2021 were enrolled. The patients were arbitrarily assigned into control group and study group. The former was treated with pramipexole, and the latter was treated with pramipexole combined with NGF...
2022: Computational and Mathematical Methods in Medicine
https://read.qxmd.com/read/35412281/retrograde-axonal-transport-of-neurotrophins-in-basal-forebrain-cholinergic-neurons
#35
JOURNAL ARTICLE
Arman Shekari, Margaret Fahnestock
Axonal transport is key for the survival and function of all neurons. This process is especially important in basal forebrain cholinergic neurons due to their extremely long and diffuse axonal projections. These neurons are critical for learning and memory and degenerate rapidly in age-related neurodegenerative disorders like Alzheimer's and Parkinson's disease. The vulnerability of these neurons to age-related neurodegeneration may be partially attributed to their reliance on retrograde axonal transport for neurotrophic support...
2022: Methods in Molecular Biology
https://read.qxmd.com/read/35064868/epigenetic-regulation-and-autophagy-modulation-debilitates-insulin-resistance-associated-alzheimer-s-disease-condition-in-rats
#36
JOURNAL ARTICLE
Violina Kakoty, Sarathlal K C, Sunil Kumar Dubey, Chih-Hao Yang, Sandhya Amol Marathe, Rajeev Taliyan
Insulin resistance (IR) and accumulation of amyloid beta (Aβ) oligomers are potential causative factor for Alzheimer's Disease (AD). Simultaneously, enhanced clearance level of these oligomers through autophagy activation bring novel insights into their therapeutic paradigm. Autophagy activation is negatively correlated with mammalian target of rapamycin (mTOR) and dysregulated mTOR level due to epigenetic alterations can further culminate towards AD pathogenesis. Therefore, in the current study we explored the neuroprotective efficacy of rapamycin (rapa) and vorinostat (vori) in-vitro and in-vivo...
April 2022: Metabolic Brain Disease
https://read.qxmd.com/read/34971085/development-and-validation-of-peg-pcl-based-nanoformulation-of-rosiglitazone-and-evaluation-of-its-brain-selectivity-in-mice-model-of-alzheimer-s-disease
#37
JOURNAL ARTICLE
Sarathlal K C, Violina K Kakoty, Rajeev Taliyan
BACKGROUND: Type-2 Diabetes Mellitus and insulin resistance increases the risk of Alzheimer's disease (AD). Recent studies highlighted the role of peroxisome proliferator-activated receptor-gamma (PPAR-γ) in modulation of AD. This study was designed to investigate the effect of rosiglitazone alone or in its nanoformulated form for an effective drug delivery in mice model of AD. METHOD: AD mice model was developed by intracerebroventricular (ICV) administration of streptozotocin (STZ)...
December 2021: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://read.qxmd.com/read/34917294/effects-of-eight-weeks-of-resistance-exercises-on-neurotrophins-and-trk-receptors-in-alzheimer-model-male-wistar-rats
#38
JOURNAL ARTICLE
Gholamhasan Jafarzadeh, Saeid Shakerian, Yaghoob Farbood, Mohsen Ghanbarzadeh
INTRODUCTION: This study evaluates the effects of 8 weeks of resistance exercises on the expression of neurotrophins and Trk receptors in Alzheimer model male Wistar rats. METHODS: For this purpose, 32 mature male Wistar rats with a mean weight of 230-280 g were chosen and divided into Alzheimer and Sham groups. The rats in the sham group received normal saline, while the ones in the Alzheimer group received streptomycin via intraventricular injection. These rats were then divided into the following four subgroups: 1) resting sham, 2) exercising sham, 3) resting Alzheimer, and 4) exercising Alzheimer...
May 2021: Basic and Clinical Neuroscience
https://read.qxmd.com/read/34826049/therapeutic-potential-of-neurotrophic-factors-in-alzheimer-s-disease
#39
REVIEW
Ava Nasrolahi, Fatemeh Javaherforooshzadeh, Mohsen Jafarzadeh-Gharehziaaddin, Javad Mahmoudi, Khadijeh Dizaji Asl, Zahra Shabani
INTRODUCTION: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia among the elderly population. AD is accompanied with the dysregulation of specific neurotrophic factors (NTFs) and their receptors, which plays a critical role in neuronal degeneration. NTFs are small proteins with therapeutic potential for human neurodegenerative diseases. These growth factors are categorized into four families: neurotrophins, neurokines, the glial cell line-derived NTF family of ligands, and the newly discovered cerebral dopamine NTF/mesencephalic astrocyte-derived NTF family...
March 2022: Molecular Biology Reports
https://read.qxmd.com/read/34798125/computational-model-of-brain-endothelial-cell-signaling-pathways-predicts-therapeutic-targets-for-cerebral-pathologies
#40
JOURNAL ARTICLE
Catherine M Gorick, Jeffrey J Saucerman, Richard J Price
Brain endothelial cells serve many critical homeostatic functions. In addition to sensing and regulating blood flow, they maintain blood-brain barrier function, including precise control of nutrient exchange and efflux of xenobiotics. Many signaling pathways in brain endothelial cells have been implicated in both health and disease; however, our understanding of how these signaling pathways functionally integrate is limited. A model capable of integrating these signaling pathways could both advance our understanding of brain endothelial cell signaling networks and potentially identify promising molecular targets for endothelial cell-based drug or gene therapies...
March 2022: Journal of Molecular and Cellular Cardiology
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