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NGF, BDNF, alzheimer disease

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https://www.readbyqxmd.com/read/29890314/active-components-derived-from-kai-xin-san-a-herbal-formula-increase-the-expressions-of-neurotrophic-factor-ngf-and-bdnf-on-mouse-astrocyte-primary-cultures-via-camp-dependent-signaling-pathway
#1
Cheng Cao, Junyuan Xiao, Mengqiu Liu, Zishuo Ge, Renjie Huang, Mingzhu Qi, Hongliang Zhu, Jin-Ao Duan, Yue Zhu
ETHNOPHARMACOLOGICAL RELEVANCE: Kai-Xin-San (KXS), an ancient formula composed of Ginseng Radix et Rhizoma, Polygalae Radix, Acori Tatarinowii Rhizoma and Poria, was frequently applied for Alzheimer's disease and major depression disorders for thousands of years. However, its active components and molecular mechanism have not clearly been investigated. AIM OF THE STUDY: We aimed to reveal the active components of KXS on regulating neurotrophic factor NGF and BDNF expressions and its mechanisms on mouse astrocyte primary cultures...
June 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29728920/l-3-n-butylphthalide-regulates-proliferation-migration-and-differentiation-of-neural-stem-cell-in-vitro-and-promotes-neurogenesis-in-app-ps1-mouse-model-by-regulating-bdnf-trkb-creb-akt-pathway
#2
Hui Lei, Yu Zhang, Longjian Huang, Shaofeng Xu, Jiang Li, Lichao Yang, Ling Wang, Changhong Xing, Xiaoliang Wang, Ying Peng
Alzheimer's disease (AD) is characterized by extracellular accumulation of β-amyloid peptides (Aβ) and intracellular neurofibrillary tangles, along with cognitive decline and neurodegeneration. The cognitive deficit is considered to be due to the dysfunction of hippocampal neurogenesis. Although L-3-n-butylphthalide (L-NBP) has been shown beneficial effects in multiple AD animal models, the underlying molecular mechanisms are still elusive. In this study, we investigated the effects of L-NBP on neurogenesis both in vitro and in vivo...
May 4, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29708824/the-short-term-improvements-of-enriched-environment-in-behaviors-and-pathological-changes-of-app-ps1-mice-via-regulating-cytokines
#3
Yuwei Zhang, Ge Wang, Lin Wang, Jian Zhao, Rui Huang, Qianying Xiong
OBJECTIVE: To study the effect of enriched environment (EE) on cognitive function and pathological changes in Alzheimer's disease (AD) mice. METHOD: 6-month-old of the male mice were divided into 3 groups (n = 8), the wild type C57BL/6 mice in the control group, the APP/PS1 transgenic mice of AD reared in either the standard environment or the EE. Mice were feeding for 8 weeks, and then moved into standard environment. The activity and cognitive function were measured by Open-field test and Morris-water Maze...
April 30, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/28865749/differential-deregulation-of-ngf-and-bdnf-neurotrophins-in-a-transgenic-rat-model-of-alzheimer-s-disease
#4
M Florencia Iulita, M Beatriz Bistué Millón, Rowan Pentz, Lisi Flores Aguilar, Sonia Do Carmo, Simon Allard, Bernadeta Michalski, Edward N Wilson, Adriana Ducatenzeiler, Martin A Bruno, Margaret Fahnestock, A Claudio Cuello
Evidence from human neuropathological studies indicates that the levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) are compromised in Alzheimer's disease. However, the causes and temporal (pathology-dependent) evolution of these alterations are not completely understood. To elucidate these issues, we investigated the McGill-R-Thy1-APP transgenic rat, which exhibits progressive intracellular and extracellular amyloid-beta (Aβ) pathology and ensuing cognitive deficits...
December 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28852153/ethyl-acetate-extract-components-of-bushen-yizhi-formula-provides-neuroprotection-against-scopolamine-induced-cognitive-impairment
#5
Shi-Jie Zhang, Dan Luo, Lin Li, Rui-Rong Tan, Qing-Qing Xu, Jie Qin, Lei Zhu, Na-Chuan Luo, Ting-Ting Xu, Rong Zhang, Lei Yang, Qi Wang
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder and there is no effective cure for this devastating disease to date. Bushen Yizhi Formula (BSYZ-F), a Chinese herbal compound, has proved to be effective for AD. In this study, we further investigate the effective part of BSYZ-F, ethyl acetate extract components of BSYZ-F (BSYZ-E), protects scopolamine (SCOP)-induced cognitive impairment, which shows a similar effect to BSYZ-F. We also find that BSYZ-E could protect against SCOP-induced cholinergic system dysfunction...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28670271/white-matter-tract-integrity-in-alzheimer-s-disease-vs-late-onset-bipolar-disorder-and-its-correlation-with-systemic-inflammation-and-oxidative-stress-biomarkers
#6
Ariadna Besga, Darya Chyzhyk, Itxaso Gonzalez-Ortega, Jon Echeveste, Marina Graña-Lecuona, Manuel Graña, Ana Gonzalez-Pinto
Background: Late Onset Bipolar Disorder (LOBD) is the development of Bipolar Disorder (BD) at an age above 50 years old. It is often difficult to differentiate from other aging dementias, such as Alzheimer's Disease (AD), because they share cognitive and behavioral impairment symptoms. Objectives: We look for WM tract voxel clusters showing significant differences when comparing of AD vs. LOBD, and its correlations with systemic blood plasma biomarkers (inflammatory, neurotrophic factors, and oxidative stress)...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28499898/antidepressant-drugs-for-beta-amyloid-induced-depression-a-new-standpoint
#7
Stefania Schiavone, Paolo Tucci, Emanuela Mhillaj, Maria Bove, Luigia Trabace, Maria Grazia Morgese
Mounting evidence suggests that depression represents a risk factor and an early manifestation of Alzheimer's disease (AD). Neuropsychiatric symptoms may derive from neurobiological changes in specific brain areas and may be considered prodromal of dementia. We have previously reported the depressive-like profile in rats receiving a single intracerebroventricular injection of soluble amyloid beta protein (ßA). Here, we verified the effect of different classes of antidepressants on the ßA-induced depressive behavior and on cortical monoamine levels...
August 1, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28498887/sex-differences-in-risk-for-alzheimer-s-disease-related-to-neurotrophin-gene-polymorphisms-the-cache-county-memory-study
#8
COMPARATIVE STUDY
Joshua Matyi, JoAnn T Tschanz, Gail B Rattinger, Chelsea Sanders, Elizabeth K Vernon, Chris Corcoran, John S K Kauwe, Mona Buhusi
Neurotrophins, including nerve-growth factor and brain-derived neurotrophic factor, have been implicated in Alzheimer's disease (AD). Associations between AD and neurotrophin signaling genes have been inconsistent, with few studies examining sex differences in risk. We examined four single-nucleotide polymorphisms (SNPs) involved in neurotrophin signaling (rs6265, rs56164415, rs2289656, rs2072446) and risk for AD by sex in a population-based sample of older adults. Three thousand four hundred and ninety-nine individuals without dementia at baseline [mean (standard deviation) age = 74...
November 9, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28442348/upregulation-of-neurotrophins-by-s-47445-a-novel-positive-allosteric-modulator-of-ampa-receptors-in-aged-rats
#9
Francesca Calabrese, Elisa Savino, Elisabeth Mocaer, Sylvie Bretin, Giorgio Racagni, Marco A Riva
At molecular levels, it has been shown that aging is associated with alterations in neuroplastic mechanisms. In this study, it was examined if the altered expression of neurotrophins observed in aged rats could be corrected by a chronic treatment with S 47445 (1-3-10mg/kg, p.o.), a novel selective positive allosteric modulator of the AMPA receptors. Both the mRNA and the protein levels of the neurotrophins Bdnf, NT-3 and Ngf were specifically measured in the prefrontal cortex and hippocampus (ventral and dorsal) of aged rats...
July 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28390878/protective-effects-of-different-exercise-modalities-in-an-alzheimer-s-disease-like-model
#10
Dilek Özbeyli, Gülce Sarı, Naziye Özkan, Betül Karademir, Meral Yüksel, Özlem Tuğçe Çilingir Kaya, Özgür Kasımay Çakır
Our aim was to investigate the probable protective effects of aerobic, resistance and combined exercise methods on ovariectomy and d-galactose induced Alzheimer's Disease (AD)-like model. d-galactose (100mg/kg) or saline were administered intraperitoneally for 6 weeks to ovariectomized or sham-operated rats (n=8/group). Aerobic (AE), resistance (RE) and combined exercises (CE) (aerobic+resistance) were performed for 3 times a week for 6 weeks. Anxiety level and cognitive functions were evaluated via hole-board and object recognition tests...
June 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28336494/minocycline-reduces-inflammatory-parameters-in-the-brain-structures-and-serum-and-reverses-memory-impairment-caused-by-the-administration-of-amyloid-%C3%AE-1-42-in-mice
#11
Michelle Lima Garcez, Francielle Mina, Tatiani Bellettini-Santos, Franciellen Gonçalves Carneiro, Aline Pereira Luz, Gustavo Luis Schiavo, Matheus Scopel Andrighetti, Maylton Grégori Scheid, Renan Pereira Bolfe, Josiane Budni
Alzheimer's disease (AD) is a neurodegenerative disorder and the most common type of age-related dementia. Cognitive decline, beta-amyloid (Aβ) accumulation, neurofibrillary tangles, and neuroinflammation are the main pathophysiological characteristics of AD. Minocycline is a tetracycline derivative with anti-inflammatory properties that has a neuroprotective effect. The aim of this study was to evaluate the effect of minocycline on memory, neurotrophins and neuroinflammation in an animal model of AD induced by the administration of Aβ (1-42) oligomer...
July 3, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/27984078/anti-inflammatory-and-protective-effects-of-mt-031-a-novel-multitarget-mao-a-and-ache-buche-inhibitor-in-scopolamine-mouse-model-and-inflammatory-cells
#12
Wei Liu, Alon Rabinovich, Yuval Nash, Dan Frenkel, Yuqiang Wang, Moussa B H Youdim, Orly Weinreb
Previous study demonstrated that the novel multitarget compound, MT-031 preserved in one molecule entity the beneficial properties of its parent drugs, rasagiline and rivastigmine, and exerted high dual potencies of monoamine oxidase-A (MAO-A) and cholinesterase (ChE) inhibition in acute-treated mice and neuroprotective effects against H2 O2 -induced neurotoxicity in human neuroblastoma SH-SY5Y cells. The present study aimed to further investigate the anti-inflammatory and protective effects of MT-031 in scopolamine mouse model and inflammatory cell cultures...
February 2017: Neuropharmacology
https://www.readbyqxmd.com/read/27540523/the-evaluation-of-nerve-growth-factor-over-expression-on-neural-lineage-specific-genes-in-human-mesenchymal-stem-cells
#13
Yousef Mortazavi, Fatemeh Sheikhsaran, Gholamreza Khamisipour Khamisipour, Masoud Soleimani, Ali Teimuri, Somayeh Shokri
OBJECTIVE: Treatment and repair of neurodegenerative diseases such as brain tumors, spinal cord injuries, and functional disorders, including Alzheimer's disease, are challenging problems. A common treatment approach for such disorders involves the use of mesenchymal stem cells (MSCs) as an alternative cell source to replace injured cells. However, use of these cells in hosts may potentially cause adverse outcomes such as tumorigenesis and uncontrolled differentiation. In attempt to generate mesenchymal derived neural cells, we have infected MSCs with recombinant lentiviruses that expressed nerve growth factor (NGF) and assessed their neural lineage genes...
July 2016: Cell Journal
https://www.readbyqxmd.com/read/27414248/potential-therapeutic-action-of-natural-products-from-traditional-chinese-medicine-on-alzheimer-s-disease-animal-models-targeting-neurotrophic-factors
#14
REVIEW
Shuyong Wei
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells leads to memory loss and cognitive decline. To reduce the death rate and improve the biological activity of neurocytes, neurotrophic factors (NTFs) exhibit therapeutic effect on AD. However, therapeutic application of exogenous NTFs in treatment of AD is largely limited due to short half-life, poor stability, etc. Various extracts of traditional Chinese medicine (TCM) have been shown to exhibit therapeutic effects on AD, and some of these effects are associated with regulation on the expression of nerve growth factor, brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) and their associated receptors...
December 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27356540/neurotrophins-modulation-by-olive-polyphenols
#15
REVIEW
Valentina Carito, Mauro Ceccanti, Luigi Tarani, Giampiero Ferraguti, George N Chaldakov, Marco Fiore
BACKGROUND: Polyphenols are probably the most known and investigated molecules of nutritional interest as micronutrients present in abundance in our diet. Some of the most important food sources of polyphenols in the Mediterranean diet are olives and olive oil. A growing body of evidence from animal models to clinical studies indicates that polyphenol compounds may have neuroprotective effects in several pathologies of the nervous system through the control of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26976092/gpr40-receptor-activation-leads-to-creb-phosphorylation-and-improves-cognitive-performance-in-an-alzheimer-s-disease-mouse-model
#16
Muhammad Zahid Khan, Xuxu Zhuang, Ling He
Alzheimer's disease (AD) is a very complex neurodegenerative disorder as neuronal loss is a prominent and initial feature of AD. This loss correlates with cognitive deficits more closely than amyloid load. GPR40 receptor belongs to the class of G-protein coupled receptors, is expressed in wide parts of the brain including the hippocampus which is involved in spatial learning and memory. Till now, there are few studies investigating the functional role of GPR40 in brain. In this study, we evaluated the functional role of GPR40 receptor in the A-beta AD mice model...
May 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/26425388/the-involvement-of-bdnf-ngf-and-gdnf-in-aging-and-alzheimer-s-disease
#17
REVIEW
Josiane Budni, Tatiani Bellettini-Santos, Francielle Mina, Michelle Lima Garcez, Alexandra Ioppi Zugno
Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event...
September 2015: Aging and Disease
https://www.readbyqxmd.com/read/26370080/effect-of-cholesterol-reduction-on-receptor-signaling-in-neurons
#18
Kenji Fukui, Heather A Ferris, C Ronald Kahn
Diabetes mellitus is associated with a variety of complications, including alterations in the central nervous system (CNS). We have recently shown that diabetes results in a reduction of cholesterol synthesis in the brain due to decreased insulin stimulation of SREBP2-mediated cholesterol synthesis in neuronal and glial cells. In the present study, we explored the effects of the decrease in cholesterol on neuronal cell function using GT1-7 hypothalamic cells subjected to cholesterol depletion in vitro using three independent methods: 1) exposure to methyl-β-cyclodextrin, 2) treatment with the HMG-CoA reductase inhibitor simvastatin, and 3) shRNA-mediated knockdown of SREBP2...
October 30, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26075266/phytochemicals-that-regulate-neurodegenerative-disease-by-targeting-neurotrophins-a-comprehensive-review
#19
REVIEW
Ramu Venkatesan, Eunhee Ji, Sun Yeou Kim
Alzheimer's disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem. Age, nutrition, and toxins are the most common causes of AD. However, currently no credible treatment is available for AD. Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties. They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25849905/brain-derived-neurotrophic-factor-ameliorates-learning-deficits-in-a-rat-model-of-alzheimer-s-disease-induced-by-a%C3%AE-1-42
#20
Lu Zhang, Yu Fang, Yajun Lian, Yuan Chen, Tianwen Wu, Yake Zheng, Huili Zong, Limin Sun, Ruifang Zhang, Zhenhua Wang, Yuming Xu
An emerging body of data suggests that the early onset of Alzheimer's disease (AD) is associated with decreased brain-derived neurotrophic factor (BDNF). Because BDNF plays a critical role in the regulation of high-frequency synaptic transmission and long-term potentiation in the hippocampus, the up-regulation of BDNF may rescue cognitive impairments and learning deficits in AD. In the present study, we investigated the effects of hippocampal BDNF in a rat model of AD produced by a ventricle injection of amyloid-β1-42 (Aβ1-42)...
2015: PloS One
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