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NGF, BDNF, alzheimer disease

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https://www.readbyqxmd.com/read/27540523/the-evaluation-of-nerve-growth-factor-over-expression-on-neural-lineage-specific-genes-in-human-mesenchymal-stem-cells
#1
Yousef Mortazavi, Fatemeh Sheikhsaran, Gholamreza Khamisipour Khamisipour, Masoud Soleimani, Ali Teimuri, Somayeh Shokri
OBJECTIVE: Treatment and repair of neurodegenerative diseases such as brain tumors, spinal cord injuries, and functional disorders, including Alzheimer's disease, are challenging problems. A common treatment approach for such disorders involves the use of mesenchymal stem cells (MSCs) as an alternative cell source to replace injured cells. However, use of these cells in hosts may potentially cause adverse outcomes such as tumorigenesis and uncontrolled differentiation. In attempt to generate mesenchymal derived neural cells, we have infected MSCs with recombinant lentiviruses that expressed nerve growth factor (NGF) and assessed their neural lineage genes...
July 2016: Cell Journal
https://www.readbyqxmd.com/read/27414248/potential-therapeutic-action-of-natural-products-from-traditional-chinese-medicine-on-alzheimer-s-disease-animal-models-targeting-neurotrophic-factors
#2
REVIEW
Shuyong Wei
Alzheimer's disease (AD) is a neurodegenerative disorder in which the death of brain cells leads to memory loss and cognitive decline. To reduce the death rate and improve the biological activity of neurocytes, neurotrophic factors (NTFs) exhibit therapeutic effect on AD. However, therapeutic application of exogenous NTFs in treatment of AD is largely limited due to short half-life, poor stability, etc. Various extracts of traditional Chinese medicine (TCM) have been shown to exhibit therapeutic effects on AD, and some of these effects are associated with regulation on the expression of nerve growth factor, brain-derived neurotrophic factor (BDNF), and glial cell line-derived neurotrophic factor (GDNF) and their associated receptors...
December 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/27356540/neurotrophins-modulation-by-olive-polyphenols
#3
REVIEW
Valentina Carito, Mauro Ceccanti, Luigi Tarani, Giampiero Ferraguti, George N Chaldakov, Marco Fiore
BACKGROUND: Polyphenols are probably the most known and investigated molecules of nutritional interest as micronutrients present in abundance in our diet. Some of the most important food sources of polyphenols in the Mediterranean diet are olives and olive oil. A growing body of evidence from animal models to clinical studies indicates that polyphenol compounds may have neuroprotective effects in several pathologies of the nervous system through the control of oxidative stress, inflammation, apoptosis and mitochondrial dysfunction...
2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/26976092/gpr40-receptor-activation-leads-to-creb-phosphorylation-and-improves-cognitive-performance-in-an-alzheimer-s-disease-mouse-model
#4
Muhammad Zahid Khan, Xuxu Zhuang, Ling He
Alzheimer's disease (AD) is a very complex neurodegenerative disorder as neuronal loss is a prominent and initial feature of AD. This loss correlates with cognitive deficits more closely than amyloid load. GPR40 receptor belongs to the class of G-protein coupled receptors, is expressed in wide parts of the brain including the hippocampus which is involved in spatial learning and memory. Till now, there are few studies investigating the functional role of GPR40 in brain. In this study, we evaluated the functional role of GPR40 receptor in the A-beta AD mice model...
May 2016: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/26425388/the-involvement-of-bdnf-ngf-and-gdnf-in-aging-and-alzheimer-s-disease
#5
REVIEW
Josiane Budni, Tatiani Bellettini-Santos, Francielle Mina, Michelle Lima Garcez, Alexandra Ioppi Zugno
Aging is a normal physiological process accompanied by cognitive decline. This aging process has been the primary risk factor for development of aging-related diseases such as Alzheimer's disease (AD). Cognitive deficit is related to alterations of neurotrophic factors level such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and glial cell-derived neurotrophic factor (GDNF). These strong relationship between aging and AD is important to investigate the time which they overlap, as well as, the pathophysiological mechanism in each event...
September 2015: Aging and Disease
https://www.readbyqxmd.com/read/26370080/effect-of-cholesterol-reduction-on-receptor-signaling-in-neurons
#6
Kenji Fukui, Heather A Ferris, C Ronald Kahn
Diabetes mellitus is associated with a variety of complications, including alterations in the central nervous system (CNS). We have recently shown that diabetes results in a reduction of cholesterol synthesis in the brain due to decreased insulin stimulation of SREBP2-mediated cholesterol synthesis in neuronal and glial cells. In the present study, we explored the effects of the decrease in cholesterol on neuronal cell function using GT1-7 hypothalamic cells subjected to cholesterol depletion in vitro using three independent methods: 1) exposure to methyl-β-cyclodextrin, 2) treatment with the HMG-CoA reductase inhibitor simvastatin, and 3) shRNA-mediated knockdown of SREBP2...
October 30, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26075266/phytochemicals-that-regulate-neurodegenerative-disease-by-targeting-neurotrophins-a-comprehensive-review
#7
REVIEW
Ramu Venkatesan, Eunhee Ji, Sun Yeou Kim
Alzheimer's disease (AD), characterized by progressive dementia and deterioration of cognitive function, is an unsolved social and medical problem. Age, nutrition, and toxins are the most common causes of AD. However, currently no credible treatment is available for AD. Traditional herbs and phytochemicals may delay its onset and slow its progression and also allow recovery by targeting multiple pathological causes by antioxidative, anti-inflammatory, and antiamyloidogenic properties. They also regulate mitochondrial stress, apoptotic factors, free radical scavenging system, and neurotrophic factors...
2015: BioMed Research International
https://www.readbyqxmd.com/read/25849905/brain-derived-neurotrophic-factor-ameliorates-learning-deficits-in-a-rat-model-of-alzheimer-s-disease-induced-by-a%C3%AE-1-42
#8
Lu Zhang, Yu Fang, Yajun Lian, Yuan Chen, Tianwen Wu, Yake Zheng, Huili Zong, Limin Sun, Ruifang Zhang, Zhenhua Wang, Yuming Xu
An emerging body of data suggests that the early onset of Alzheimer's disease (AD) is associated with decreased brain-derived neurotrophic factor (BDNF). Because BDNF plays a critical role in the regulation of high-frequency synaptic transmission and long-term potentiation in the hippocampus, the up-regulation of BDNF may rescue cognitive impairments and learning deficits in AD. In the present study, we investigated the effects of hippocampal BDNF in a rat model of AD produced by a ventricle injection of amyloid-β1-42 (Aβ1-42)...
2015: PloS One
https://www.readbyqxmd.com/read/25737042/decreased-neurotrophic-support-is-associated-with-cognitive-decline-in-non-demented-subjects
#9
Orestes Vicente Forlenza, Aline Silva Miranda, Izabela Guimar, Leda Leme Talib, Breno Satler Diniz, Wagner Farid Gattaz, Antonio Lucio Teixeira
BACKGROUND: There is evidence of decreased neurotrophic support in Alzheimer's disease (AD), including its prodromal stages, but it is not clear whether this abnormality represents a marker of this process. OBJECTIVE: To determine serum concentrations of a panel of neurotrophic factors (BDNF, NGF, and GDNF) in a cross-section of elderly patients with mild cognitive impairment (MCI) and AD compared to cognitively healthy controls, and to evaluate whether abnormal levels of these factors at baseline predict the transition from MCI to dementia...
2015: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/25526861/bone-marrow-derived-endothelial-progenitor-cells-protect-against-scopolamine-induced-alzheimer-like-pathological-aberrations
#10
Marwa M Safar, Hany H Arab, Sherine M Rizk, Shohda A El-Maraghy
Vascular endothelial dysfunction plays a key role in the pathogenesis of Alzheimer's disease (AD). Patients with AD have displayed decreased circulating endothelial progenitor cells (EPCs) which repair and maintain the endothelial function. Transplantation of EPCs has emerged as a promising approach for the management of cerebrovascular diseases including ischemic stroke, however, its impact on AD has been poorly described. Thus, the current study aimed at investigating the effects of bone marrow-derived (BM) EPCs transplantation in repeated scopolamine-induced cognitive impairment, an experimental model that replicates biomarkers of AD...
April 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/25407931/mir-126-regulates-growth-factor-activities-and-vulnerability-to-toxic-insult-in-neurons
#11
Woori Kim, Haneul Noh, Yenarae Lee, Jeha Jeon, Arthi Shanmugavadivu, Donna L McPhie, Kwang-Soo Kim, Bruce M Cohen, Hyemyung Seo, Kai C Sonntag
Dysfunction of growth factor (GF) activities contributes to the decline and death of neurons during aging and in neurodegenerative diseases. In addition, neurons become more resistant to GF signaling with age. Micro (mi)RNAs are posttranscriptional regulators of gene expression that may be crucial to age- and disease-related changes in GF functions. MiR-126 is involved in regulating insulin/IGF-1/phosphatidylinositol-3-kinase (PI3K)/AKT and extracellular signal-regulated kinase (ERK) signaling, and we recently demonstrated a functional role of miR-126 in dopamine neuronal cell survival in models of Parkinson's disease (PD)-associated toxicity...
January 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/25342942/noradrenergic-regulation-of-glial-activation-molecular-mechanisms-and-therapeutic-implications
#12
David Braun, Jose L M Madrigal, Douglas L Feinstein
It has been known for many years that the endogenous neurotransmitter noradrenaline (NA) exerts anti-inflammatory and neuroprotective effects both in vitro and in vivo. In many cases the site of action of NA are beta-adrenergic receptors (βARs), causing an increase in intracellular levels of cAMP which initiates a broad cascade of events including suppression of inflammatory transcription factor activities, alterations in nuclear localization of proteins, and induction of patterns of gene expression mediated through activity of the CREB transcription factor...
July 2014: Current Neuropharmacology
https://www.readbyqxmd.com/read/25044076/lamotrigine-attenuates-deficits-in-synaptic-plasticity-and-accumulation-of-amyloid-plaques-in-app-ps1-transgenic-mice
#13
Mao-Ying Zhang, Chuan-Yi Zheng, Ming-Ming Zou, Jian-Wei Zhu, Yan Zhang, Jing Wang, Chun-Feng Liu, Qi-Fa Li, Zhi-Cheng Xiao, Shao Li, Quan-Hong Ma, Ru-Xiang Xu
Hyperactivity and its compensatory mechanisms may causally contribute to synaptic and cognitive deficits in Alzheimer's disease (AD). Blocking the overexcitation of the neural network, with levetiracetam (LEV), a sodium channel blocker applied in the treatment of epilepsy, prevented synaptic and cognitive deficits in human amyloid precursor protein (APP) transgenic mice. This study has brought the potential use of antiepileptic drugs (AEDs) in AD therapy. We showed that the chronic treatment with lamotrigine (LTG), a broad-spectrum AED, suppressed abnormal spike activity, prevented the loss of spines, synaptophysin immunoreactivity, and neurons, and thus attenuated the deficits in synaptic plasticity and learning and memory in APP and presenilin 1 (PS1) mice, which express human mutant APP and PS1...
December 2014: Neurobiology of Aging
https://www.readbyqxmd.com/read/25026432/the-effect-of-neuropeptide-y-on-cell-survival-and-neurotrophin-expression-in-in-vitro-models-of-alzheimer-s-disease
#14
REVIEW
Francesco Angelucci, Francesca Gelfo, Marco Fiore, Nicoletta Croce, Aleksander A Mathé, Sergio Bernardini, Carlo Caltagirone
Alzheimer's disease (AD) is a disorder characterized by the accumulation of abnormally folded protein fragments in neurons, i.e., β-amyloid (Aβ) and tau protein, leading to cell death. Several neuropeptides present in the central nervous system (CNS) are believed to be involved in the pathophysiology of AD. Among them, neuropeptide Y (NPY), a small peptide widely distributed throughout the brain, has generated interest because of its role in neuroprotection against excitotoxicity in animal models of AD. In addition, it has been shown that NPY modulates neurogenesis...
August 2014: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/24948063/metrifonate-like-acetylcholine-up-regulates-neurotrophic-activity-of-cultured-rat-astrocytes
#15
Tina Mele, Damijana Mojca Jurič
BACKGROUND: Metrifonate is an inhibitor of acetylcholinesterase (AChE). Several studies confirmed its positive effects on cognitive impairment in Alzheimer's disease but it was due to adverse events withdrawn from clinical trials. Based on the importance of astrocytes in physiological and pathological brain activities we investigated the impact of metrifonate and, for comparison, acetylcholine on intrinsic neurotrophic activity in these cells. METHODS: Metabolic activity, intracellular adenosine 5'-triphosphate (ATP) levels and lactate dehydrogenase (LDH) release was measured to examine the impact of metrifonate on viability and integrity of cultured rat cortical astrocytes...
August 2014: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/24732467/igf2-ameliorates-amyloidosis-increases-cholinergic-marker-expression-and-raises-bmp9-and-neurotrophin-levels-in-the-hippocampus-of-the-appsweps1de9-alzheimer-s-disease-model-mice
#16
Tiffany J Mellott, Sarah M Pender, Rebecca M Burke, Erika A Langley, Jan Krzysztof Blusztajn
The development of an effective therapy for Alzheimer's disease (AD) is a major challenge to biomedical sciences. Because much of early AD pathophysiology includes hippocampal abnormalities, a viable treatment strategy might be to use trophic factors that support hippocampal integrity and function. IGF2 is an attractive candidate as it acts in the hippocampus to enhance memory consolidation, stimulate adult neurogenesis and upregulate cholinergic marker expression and acetylcholine (ACh) release. We performed a seven-day intracerebroventricular infusion of IGF2 in transgenic APPswe...
2014: PloS One
https://www.readbyqxmd.com/read/24576746/increased-plasma-levels-of-bdnf-and-inflammatory-markers-in-alzheimer-s-disease
#17
Mayara Chaves Faria, Gisele Santos Gonçalves, Natália Pessoa Rocha, Edgar Nunes Moraes, Maria Aparecida Bicalho, Marco Túlio Gualberto Cintra, Jonas Jardim de Paula, Luís Felipe José Ravic de Miranda, Alessandro Clayton de Souza Ferreira, Antônio Lúcio Teixeira, Karina Braga Gomes, Maria das Graças Carvalho, Lirlândia P Sousa
Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Neurotrophic factors and inflammatory markers may play considerable roles in AD. In this study we measured, through Enzyme-Linked Immunosorbent Assay, the plasma levels of brain derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF) and neuronal growth factor (NGF), as well as tumor necrosis factor-alpha soluble receptors, sTNFR1 and sTNFR2, and soluble intercellular adhesion molecule 1 (sICAM-1), in 50 AD patients, 37 patients with mild cognitive impairment (MCI) and 56 healthy elderly controls...
June 2014: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/24533803/peptide-therapeutics-in-neurodegenerative-disorders
#18
REVIEW
Shashi Kant Tiwari, Rajnish K Chaturvedi
Neurodegenerative diseases are characterized by selective and progressive degeneration of neuronal population in the brain, and associated behavioural, motor, psychiatric and cognitive impairments. Aggregation of pathogenic proteins, mitochondrial dysfunction, oxidative stress, transcriptional dysfunction and apoptosis play an important role in the pathogenesis of neurodegenerative disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease and Amyotrophic lateral sclerosis. Therefore, novel therapies that target each of these mechanisms may be effective in abating the symptoms and slow down the onset and progression of neurodegenerative disorders...
2014: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/24463293/use-of-genetically-modified-mesenchymal-stem-cells-to-treat-neurodegenerative-diseases
#19
REVIEW
Robert D Wyse, Gary L Dunbar, Julien Rossignol
The transplantation of mesenchymal stem cells (MSCs) for treating neurodegenerative disorders has received growing attention recently because these cells are readily available, easily expanded in culture, and when transplanted, survive for relatively long periods of time. Given that such transplants have been shown to be safe in a variety of applications, in addition to recent findings that MSCs have useful immunomodulatory and chemotactic properties, the use of these cells as vehicles for delivering or producing beneficial proteins for therapeutic purposes has been the focus of several labs...
January 23, 2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/24251394/dysregulation-of-neurotrophic-and-haematopoietic-growth-factors-in-alzheimer-s-disease-from-pathophysiology-to-novel-treatment-strategies
#20
REVIEW
Kateryna Sopova, Katerina Gatsiou, Konstantinos Stellos, Christoph Laske
Alzheimer's disease (AD) is the leading cause of dementia in the elderly. Growth factors have been demonstrated to act in a synergistic way in angiogenesis and neurogenesis contributing to self-healing powers of the adult human brain. A growing body of evidence demonstrates that levels of many growth factors (neurotrophins and hematopoietins) are altered in cerebrospinal fluid and peripheral blood from AD patients and in animal models of AD. The present review summarizes the role of several neurotrophic growth factors (e...
January 2014: Current Alzheimer Research
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