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https://www.readbyqxmd.com/read/29444520/remodeling-of-wall-mechanics-and-the-myogenic-mechanism-of-rat-intramural-coronary-arterioles-in-response-to-a-short-term-daily-exercise-program-role-of-endothelial-factors
#1
Mária Szekeres, György L Nádasy, Gabriella Dörnyei, Annamária Szénási, Akos Koller
PURPOSE: Exercise elicits early adaptation of coronary vessels enabling the coronary circulation to respond adequately to higher flow demands. We hypothesized that short-term daily exercise induces biomechanical and functional remodeling of the coronary resistance arteries related to pressure. METHODS: Male rats were subjected to a progressively increasing 4-week treadmill exercise program (over 60 min/day, 1 mph in the final step). In vitro pressure-diameter measurements were performed on coronary segments (119 ± 5 μm in diameter at 50 mm Hg) with microarteriography...
February 14, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29444489/continuous-directed-evolution-for-strain-and-protein-engineering
#2
REVIEW
Simon d'Oelsnitz, Andrew Ellington
Continuous directed evolution is the 'while loop' of synthetic biology, autonomous cycles of mutation, selection, and self-replication that can lead to the rapid development of industrially relevant organisms, pathways, or molecules. Although this engineering strategy requires particular mutagenesis methods and well-defined selections, recent advances have facilitated its implementation. Control over selection pressure has been augmented by novel cost-effective continuous culturing devices with open source designs...
February 11, 2018: Current Opinion in Biotechnology
https://www.readbyqxmd.com/read/29444433/microrna-223-suppresses-the-canonical-nf-%C3%AE%C2%BAb-pathway-in-basal-keratinocytes-to-dampen-neutrophilic-inflammation
#3
Wenqing Zhou, Arpita S Pal, Alan Yi-Hui Hsu, Theodore Gurol, Xiaoguang Zhu, Sara E Wirbisky-Hershberger, Jennifer L Freeman, Andrea L Kasinski, Qing Deng
MicroRNA-223 is known as a myeloid-enriched anti-inflammatory microRNA that is dysregulated in numerous inflammatory conditions. Here, we report that neutrophilic inflammation (wound response) is augmented in miR-223-deficient zebrafish, due primarily to elevated activation of the canonical nuclear factor κB (NF-κB) pathway. NF-κB over-activation is restricted to the basal layer of the surface epithelium, although miR-223 is detected throughout the epithelium and in phagocytes. Not only phagocytes but also epithelial cells are involved in miR-223-mediated regulation of neutrophils' wound response and NF-κB activation...
February 13, 2018: Cell Reports
https://www.readbyqxmd.com/read/29444369/rotaviral-non-structural-protein-4-triggers-dynamin-related-protein-1-dependent-mitochondrial-fragmentation-during-infection
#4
Arpita Mukherjee, Upayan Patra, Rahul Bhowmick, Mamta Chawla-Sarkar
Dynamic equilibrium between mitochondrial fission and mitochondrial fusion serves as an important quality control system within cells ensuring cellular vitality and homeostasis. Viruses often target mitochondrial dynamics as a part of their obligatory cellular reprogramming. The present study was undertaken to assess the status and regulation of mitochondrial dynamics during rotavirus (RV) infection. Distinct fragmentation of mitochondrial syncytia was observed during late hours of RV (SA11, Wa, A5-13) infection...
February 14, 2018: Cellular Microbiology
https://www.readbyqxmd.com/read/29444219/complex-cases-of-acquired-pulmonary-vein-stenosis-after-radiofrequency-ablation-is-surgical-repair-an-option
#5
Katharina Schoene, Philipp Sommer, Arash Arya, Martin Kostelka, Friedrich W Mohr, Martin Misfeld, Marcel Vollroth, Andreas Bollmann, Julia Lurz, Gerhard Hindricks, Joerg Seeburger
Aims: Results of catheter based interventional treatment for pulmonary vein stenosis (PVS) following radiofrequency ablation (RFA) for atrial fibrillation remain suboptimal. Surgical repair may represent an alternative therapy, though long-term results have not been thoroughly investigated. Methods and results: We retrospectively assessed all patients in our centre undergoing surgical repair for radiofrequency-induced PVS. Data regarding surgical technique, clinical outcome, and rate of pulmonary vein (PV) restenosis were collected and analysed...
February 12, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29444215/long-term-outcomes-of-laparoscopic-large-hiatus-hernia-repair-with-nonabsorbable-mesh
#6
A C Gordon, C Gillespie, J Son, T Polhill, S Leibman, G S Smith
The use of mesh to augment suture repair of large hiatus hernias remains controversial. Repair with mesh may help reduce the recurrence rate of primary repair, but concerns about the potential for serious complications, such as mesh erosion or stricturing, continue to limit its use. We aim to evaluate the long-term outcome of primary hiatus hernia repair with lightweight polypropylene mesh (TiMesh) specifically looking at rates of clinical recurrence, dysphagia, and mesh-related complications. From a prospectively maintained database, 50 consecutive patients who underwent elective primary laparoscopic hiatal hernia repair with TiMesh between January 2005 and December 2007 were identified...
February 9, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29444198/alveolar-ridge-augmentation-with-three-dimensional-printed-hydroxyapatite-devices-a-preclinical-study
#7
Joseph P Fiorellini, Michael R Norton, Kevin WanXin Luan, David Minjoon Kim, Kei Wada, Hector L Sarmiento
The objective of this study was to evaluate the effectiveness of precise three-dimensional hydroxyapatite printed micro- and macrochannel devices for alveolar ridge augmentation in a canine model. All grafts induced minimal inflammatory and fibrotic reactions. Examination of undecalcified sections revealed that both types of grafts demonstrated bone ingrowth. The majority of the bone growth into the block graft was into the channels, though a portion grew directly into the construct in the form of small bony spicules...
February 14, 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29443989/optical-see-through-maxwellian-near-to-eye-display-with-an-enlarged-eyebox
#8
Seong-Bok Kim, Jae-Hyeung Park
We propose a Maxwellian near-to-eye display implemented using a multiplexed holographic optical element. Maxwellian configuration removes the focal cue of the displayed virtual image completely, presenting an always-focused image to the observer regardless of the focal length of the eye. The transparent property of the holographic optical element enables the optical see-through feature, making the proposed near-to-eye display suitable for augmented reality applications. The multiplexing of multiple concave mirrors into a single holographic optical element enlarges the effective eyebox, relaxing the limitation of the conventional Maxwellian displays...
February 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29443957/bone-cement-augmented-short-segment-pedicle-screw-fixation-for-k%C3%A3-mmell-disease-with-spinal-canal-stenosis
#9
Yan-Sheng Huang, Chao-Yuan Ge, Hang Feng, Hai-Ping Zhang, Xing-Bang Niu, Shao-Yan Shi, Zi-Qi Zhu, Ding-Jun Hao
BACKGROUND This study aimed to explore the feasibility and efficacy of bone cement-augmented short-segmental pedicle screw fixation in treating Kümmell disease. MATERIAL AND METHODS From June 2012 to June 2015, 18 patients with Kümmell disease with spinal canal stenosis were enrolled in this study. Each patient was treated with bone cement-augmented short-segment fixation and posterolateral bone grafting, and posterior decompression was performed when needed. All patients were followed up for 12-36 months...
February 14, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29443862/red-tides-mass-casualty-and-whole-blood-at-sea-red-tides
#10
Benjamin T Miller, Andrew H Lin, Susan C Clark, Andrew P Cap, Joseph J Dubose
BACKGROUND: The U.S. Navy's casualty-receiving ships provide remote damage control resuscitation (RDCR) platforms to treat injured combatants deployed afloat and ashore. We report a significant mass casualty incident aboard the USS Bataan, and the most warm fresh whole blood (WFWB) transfused at sea for traumatic hemorrhagic shock since the Vietnam War. METHODS: Casualty-receiving ships have robust medical capabilities, including a frozen blood bank with packed red blood cells (pRBC) and fresh frozen plasma (FFP)...
February 13, 2018: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/29442878/nanoparticle-structures-with-un-hydrogenated-castor-oil-as-hydrophobic-paper-coating
#11
Pieter Samyn, Leo Vonck, Dirk Stanssens, Henk Van den Abbeele
The encapsulation of vegetable oils within an aqueous dispersion of polymer nanoparticles provides an alternative route to create functional paper coatings from renewable resources, by combining the presentation of hydrophobic moieties together with variations in roughness at the paper surface. The effects of two selected vegetable oil types, i.e., castor oil and hydrogenated castor oil (wax), are compared in terms of nanoparticle synthesis, coating hydrophobicity and surface gloss. The nanoparticles were synthesized by adding 50 wt...
May 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442709/radiosensitization-by-liposome-encapsulated-fullerenes-to-mitochondria-dna-damages-on-human-melanoma-cells
#12
Shinya Kato, Tetsuro Yoshimura, Nobuhiko Miwa
The polyhydroxy small-gap fullerenes [C120O30(OH)30 · 30H2O · 25Na+: SGFs] were encapsulated in multilamellar liposomes (Lpsm) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-phospho-l-serine (DOPS), which are designated as LpsmSGFs (DOPC/DOPS/SGFs = 35 mM:15 mM:246-445 μM, diameter = 141.2 nm, ζ-potential = -35.65 mV). Radiosensitization by LpsmSGFs under X-ray irradiation was evaluated on human melanoma HMV-II cells. On 7th day after X-ray irradiation, cell proliferation degree assessed by WST-8 decreased more markedly on cells pretreated with LpsmSGFs than Lpsm or free-SGFs...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29442609/caveat-emptor-folate-in-unipolar-depressive-illness-a-systematic-review-and-meta-analysis
#13
Emmert Roberts, Ben Carter, Allan H Young
BACKGROUND: International guideline recommendations for the use of folate and its derivatives in the treatment of unipolar depressive disorders are confused and contradictory, perhaps reflecting wide variations in the underpinning evidence base. INTRODUCTION: We discuss differing methods of evidence synthesis in the formulation of international guideline recommendations. As an example we evaluated the efficacy of folate and its derivatives in unipolar depression via systematic review and meta-analysis...
February 1, 2018: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/29442461/central-aortic-pressure-arterial-stiffness-and-echocardiographic-parameters-of-children-with-overweight-obesity-and-arterial-hypertension
#14
Jerzy Wójtowicz, Aleksandra Łempicka, Włodzimierz Łuczyński, Wojciech Szczepański, Aleksandra Zomerfeld, Kornel Semeran, Artur Bossowski
BACKGROUND: A non-invasive estimation of central aortic pressure and echocardiographic parameters, and appropriate interpretation thereof make it possible to determine the status of the vascular wall and myocardium. These parameters are early markers of unfavorable remodeling of the cardiovascular system. OBJECTIVES: The aim of this study was to analyze the central aortic pressure and echocardiographic parameters of overweight/obese children (with or without concomitant arterial hypertension)...
December 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/29441940/il-1%C3%AE-mediated-nf-%C3%AE%C2%BAb-signaling-augments-the-osteosarcoma-cell-growth-through-modulating-mir-376c-tgfa-axis
#15
Bo Liu, Yu Zhou, Xia Chen, Dan Peng
Overexpression of IL-1β, one of the most well-known pro-inflammatory cytokines, is related to a plenty of diseases including cancer. Diversion of microRNAs exposed to pro-inflammatory cytokines have been noted in cancer cells, however, their functions in inflammation stress are still to be further studied. In our previous study, we reported that miR-376c inhibited the growth of osteosarcoma (OS) cells by targeting TGFA. Here, we revealed that miR-376c was downregulated in OS tissues and cells while IL-1β, NF-κB and TGFA were upregulated in OS tissues and cells...
July 3, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441683/cardiovascular-safety-of-prokinetic-agents-a-focus-on-drug-induced-arrhythmias
#16
REVIEW
J R Giudicessi, M J Ackerman, M Camilleri
BACKGROUND: Gastrointestinal sensorimotor dysfunction underlies a wide range of esophageal, gastric, and intestinal motility and functional disorders that collectively constitute nearly half of all referrals to gastroenterologists. As a result, substantial effort has been dedicated toward the development of prokinetic agents intended to augment or restore normal gastrointestinal motility. However, the use of several clinically efficacious gastroprokinetic agents, such as cisapride, domperidone, erythromycin, and tegaserod, is associated with unfavorable cardiovascular safety profiles, leading to restrictions in their use...
February 14, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29441616/augmenting-photoinduced-transport-in-a-single-component-gel-system-through-room-temperature-controlled-in-situ-gel-crystal-transformation
#17
Sitakant Satapathy, Palani Prabakaran, Edamana Prasad
Smart single component materials with versatile functions requires pre-programming of a higher order molecular assembly. The contribution here introduces an electroactive supergelator (c = 0.07 wt%), i.e., triphenyl amine core appended poly(aryl ether) dendron (TPAPAE), where the substantial dendritic effect improves the order and crystallinity by switching the local minimum from self-assembled molecular wires to thermodynamically favourable global minimum of ordered crystals, ripened within the fibers. Controlled in situ phase change at room temperature ultimately stabilized the mixed valence states in the single component supramolecular assembly with an amplified photoluminescence and photoinduced charge transport by two orders of magnitude...
February 14, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29441610/a-cross-sectional-single-institution-study-of-quality-of-life-in-adult-patients-with-spina-bifida
#18
Caitlin T Coco, Bhalaajee Meenakshi-Sundaram, Ahmed Eldefrawy, Millard L Henry, Tanya Watts, Christopher E Aston, Jennifer Lewis, Dominic C Frimberger, Gennady Slobodov
OBJECTIVE: To describe and compare differences in perception of independence, urinary continence, and quality of life in an adult spina bifida (SB) population. METHODS: We collected data on adult neurogenic bladder patients which included demographics, relevant procedures, and quality of life (QoL) questionnaires. QoL and functional outcomes were assessed using spinal cord independence measure (SCIM) and SF-8 health questionnaire. International consultation of incontinence questionnaire (ICIQ) was used to assess incontinence...
February 14, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29441476/augmented-renal-clearance-in-critically-ill-patients-a-systematic-review
#19
REVIEW
Idoia Bilbao-Meseguer, Alicia Rodríguez-Gascón, Helena Barrasa, Arantxazu Isla, María Ángeles Solinís
BACKGROUND: Traditionally, renal function in critically ill patients has been assessed to identify renal dysfunction, and dose adjustment is generally accepted in such a context. Nevertheless, augmented renal clearance (ARC) is a less well-studied phenomenon that could lead to faster elimination of drugs, resulting in subtherapeutic concentrations and poorer clinical outcomes when standard dosage guidelines are followed. OBJECTIVE: The aim of this systematic review was to gather and summarise all the available evidence on ARC in critically ill patients, including its definition, underlying mechanisms, epidemiology, diagnosis and impact on both drug pharmacokinetics and clinical outcomes...
February 13, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29441279/externally-applied-compression-therapy-for-fontan-patients
#20
Joseph Hernandez, Steven G Chopski, Sam Lee, William B Moskowitz, Amy L Throckmorton
Background: Limited therapeutic options are available for Fontan patients with dysfunctional or failing single ventricle physiology. This study describes the evaluation of an alternative, non-invasive, at-home therapeutic compression treatment for Fontan patients. Our hypothesis is that routinely administered, externally applied compression treatments to the lower extremities will augment systemic venous return, improve ventricular preload, and thus enhance cardiac output in Fontan patients...
January 2018: Translational Pediatrics
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