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https://www.readbyqxmd.com/read/28092864/augmentation-of-humoral-and-cellular-immunity-in-response-to-tetanus-and-diphtheria-toxoids-by-supercritical-carbon-dioxide-extracts-of-hippophae-rhamnoides-l-leaves
#1
Bindhya Jayashankar, Divya Singh, Himanshi Tanwar, K P Mishra, Swetha Murthy, Sudipta Chanda, Jigni Mishra, R Tulswani, K Misra, S B Singh, Lilly Ganju
Hippophae rhamnoides L. commonly known as Seabuckthorn (SBT), a wild shrub of family Elaegnacea, has extensively used for treating various ailments like skin diseases, jaundice, asthma, lung troubles. SBT leaves have been reported to possess several pharmacological properties including immunomodulatory, antioxidant, anti-inflammatory, antimicrobial and tissue regeneration etc. The present study was undertaken to evaluate the adjuvant property of supercritical carbon dioxide extracts (SCEs 300ET and 350ET) of SBT leaves in balb/c mice immunized with Tetanus and Diphtheria toxoids...
January 13, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28092808/antinociceptive-effect-of-co-administered-nmda-and-histamine-h4-receptor-antagonists-in-a-rat-model-of-acute-pain
#2
Renata Wolińska, Anna Leśniak, Małgorzata Żochowska, Mariusz Sacharczuk, Katarzyna Kieć-Kononowicz, Magdalena Bujalska-Zadrożny
BACKGROUND: The histamine H4 receptor (H4R) has attracted a lot of attention in terms of its role in antinociception. The N-Methyl-d-aspartic acid (NMDA) receptor is a well-characterized participant in pain pathways. However, it's influence on H4R signaling is poorly understood. Thus, in the present study we investigated the effect of a selective H4R antagonist JNJ7777120 (25mg/kg) and a NMDA receptor antagonist MK-801 (0.1-10μg) on nociceptive thresholds in a rat acute pain model. METHODS: The influence of intrathecally (it), intracerebroventricularly (icv) and intraplantarly (ipl) administered MK-801 co-injected with JNJ7777120 administered intraperitoneally (ip) was determined in the modified Randall-Selitto paw pressure, the tail flick and plantar tests...
October 29, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28092772/the-expression-of-endothelin-1-in-chronic-lymphocytic-leukemia-is-controlled-by-epigenetic-mechanisms-and-extracellular-stimuli
#3
Silvia Martinelli, Rossana Maffei, Stefania Fiorcari, Chiara Quadrelli, Patrizia Zucchini, Stefania Benatti, Leonardo Potenza, Mario Luppi, Roberto Marasca
Endothelin-1 (ET-1) is a hormone peptide widely expressed and is involved in several biological processes, important not only for normal cell function but also for tumor development, including cell proliferation, invasion, metastasis, angiogenesis and osteogenesis. In accordance, ET-1 was already shown to contribute to the growth and progression of many different solid cancers. We recently demonstrated that ET-1 has a role in the pathogenesis of chronic lymphocytic leukemia (CLL) where it is abnormally expressed...
December 30, 2016: Leukemia Research
https://www.readbyqxmd.com/read/28092587/learning-domain-invariant-subspace-using-domain-features-and-independence-maximization
#4
Ke Yan, Lu Kou, David Zhang
Domain adaptation algorithms are useful when the distributions of the training and the test data are different. In this paper, we focus on the problem of instrumental variation and time-varying drift in the field of sensors and measurement, which can be viewed as discrete and continuous distributional change in the feature space. We propose maximum independence domain adaptation (MIDA) and semi-supervised MIDA to address this problem. Domain features are first defined to describe the background information of a sample, such as the device label and acquisition time...
January 16, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28092579/cooperative-adaptive-output-regulation-for-second-order-nonlinear-multiagent-systems-with-jointly-connected-switching-networks
#5
Wei Liu, Jie Huang
This paper studies the cooperative global robust output regulation problem for a class of heterogeneous second-order nonlinear uncertain multiagent systems with jointly connected switching networks. The main contributions consist of the following three aspects. First, we generalize the result of the adaptive distributed observer from undirected jointly connected switching networks to directed jointly connected switching networks. Second, by performing a new coordinate and input transformation, we convert our problem into the cooperative global robust stabilization problem of a more complex augmented system via the distributed internal model principle...
January 11, 2017: IEEE Transactions on Neural Networks and Learning Systems
https://www.readbyqxmd.com/read/28092541/quality-assessment-of-sharpened-images-challenges-methodology-and-objective-metrics
#6
Lukas Krasula, Patrick Le Callet, Karel Fliegel, Milos Klima
Most of the effort in image quality assessment (QA) has been so far dedicated to the degradation of the image. However, there are also many algorithms in the image processing chain that can enhance the quality of an input image. These include procedures for contrast enhancement, deblurring, sharpening, up-sampling, denoising, transfer function compensation, etc. In this work, possible strategies for the quality assessment of sharpened images are investigated. This task is not trivial because the sharpening techniques can increase the perceived quality, as well as introduce artifacts leading to the quality drop (over-sharpening)...
January 10, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28092517/transformations-based-on-continuous-piecewise-affine-velocity-fields
#7
Oren Freifeld, Soren Hauberg, Kayhan Batmanghelich, John W Fisher
We propose novel finite-dimensional spaces of well-behaved Rn → Rn transformations. The latter are obtained by (fast and highly-accurate) integration of continuous piecewise-affine velocity fields. The proposed method is simple yet highly expressive, effortlessly handles optional constraints (e.g., volume preservation and/or boundary conditions), and supports convenient modeling choices such as smoothing priors and coarse-to-fine analysis. Importantly, the proposed approach, partly due to its rapid likelihood evaluations and partly due to its other properties, facilitates tractable inference over rich transformation spaces, including using Markov-Chain Monte-Carlo methods...
January 11, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28092462/adolescent-cardiovascular-functional-and-structural-outcomes-of-growth-trajectories-from-infancy-prospective-community-based-study
#8
Alanna N Hanvey, Fiona K Mensah, Susan A Clifford, Melissa Wake
BACKGROUND: Adult BMI trajectories outperform single BMI measurements as predictors of cardiovascular mortality; however, it is unknown whether this also holds in childhood. We aimed to identify BMI trajectory categories from birth to adolescence, and examine their associations with adolescent cardiovascular function and structure. METHODS: Adolescents from a community-based prospective birth cohort completed 11-16 BMI measurements between birth and adolescence...
January 16, 2017: Childhood Obesity
https://www.readbyqxmd.com/read/28092413/disruption-of-right-posterior-parietal-cortex-by-ctbs-alters-the-control-of-body-balance-in-quiet-stance
#9
David Kaulmann, Joachim Hermsdörfer, Leif Johannsen
Control of body balance relies on the integration of multiple sensory modalities. Lightly touching an earth-fixed reference augments the control of body sway. We aimed to advance the understanding of cortical integration of an afferent signal from light fingertip contact (LT) for the stabilisation of standing body balance. Assuming that right-hemisphere Posterior Parietal Cortex (rPPC) is involved in the integration and processing of touch for postural control, we expected that disrupting rPPC would attenuate any effects of light touch...
January 16, 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28092335/distribution-pattern-of-the-superior-and-the-inferior-labial-arteries-impact-for-safe-upper-and-lower-lip-augmentation-procedures
#10
Cotofana Sebastian, Pretterklieber Bettina, Lucius Runhild, Frank Konstantin, Haas Maximilian, Schenck L Thilo, Gleiser Corinna, Weyers Imke, Wedel Thilo, Pretterklieber Michael
BACKGROUND: Understanding the precise position and course of the superior and inferior labial arteries within the upper and the lower lip is crucial for safe and complication free applications of volumizing materials. METHODS: 193 anatomic head specimens (56.5% females) of Caucasian ethnicity were investigated in this large multi-centric anatomical study. In total six 3cm long vertical incisions were performed on each lip (midline and 1cm medial to the angles of the mouth) to identify the position of the superior and the inferior labial arteries in relation to the orbicularis oris muscle...
January 12, 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28092146/bovine-pericardium-graft-augmentation-versus-native-tissue-repair-in-anterior-prolapse-surgery-a-retrospective-study
#11
Rodolfo Milani, Matteo Frigerio, Carlo Beretta, Alice Cola, Federico Spelzini, Stefano Manodoro
No abstract text is available yet for this article.
January 13, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28092055/differentiating-emotional-processing-and-attention-in-psychopathy-with-functional-neuroimaging
#12
Nathaniel E Anderson, Vaughn R Steele, J Michael Maurer, Vikram Rao, Michael R Koenigs, Jean Decety, David S Kosson, Vince D Calhoun, Kent A Kiehl
Individuals with psychopathy are often characterized by emotional processing deficits, and recent research has examined the specific contexts and cognitive mechanisms that underlie these abnormalities. Some evidence suggests that abnormal features of attention are fundamental to emotional deficits in persons with psychopathy, but few studies have demonstrated the neural underpinnings responsible for such effects. Here, we use functional neuroimaging to examine attention-emotion interactions among incarcerated individuals (n = 120) evaluated for psychopathic traits using the Hare Psychopathy Checklist-Revised (PCL-R)...
January 16, 2017: Cognitive, Affective & Behavioral Neuroscience
https://www.readbyqxmd.com/read/28092019/urb597-and-the-cannabinoid-win55-212-2-reduce-behavioral-and-neurochemical-deficits-induced-by-mptp-in-mice-possible-role-of-redox-modulation-and-nmda-receptors
#13
Angel Escamilla-Ramírez, Esperanza García, Guadalupe Palencia-Hernández, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Julio Sotelo, Abel Santamaría
Several physiological events in the brain are regulated by the endocannabinoid system (ECS). While synthetic cannabinoid receptor (CBr) agonists such as WIN55,212-2 act directly on CBr, agents like URB597, a fatty acid amide hydrolase (FAAH) inhibitor, induce a more "physiological" activation of CBr by increasing the endogenous levels of the endocannabinoid anandamide (AEA). Herein, we compared the pre- and post-treatment efficacy of URB597 and WIN55,212-2 on different endpoints evaluated in the toxic model produced by the mitochondrial toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice...
January 14, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28091956/does-caffeine-influence-the-anticholinesterase-and-antioxidant-properties-of-donepezil-evidence-from-in-vitro-and-in-vivo-studies
#14
Ganiyu Oboh, Opeyemi Babatunde Ogunsuyi, Oluwaseyi Emmanuel Olonisola
Caffeine is adjudged world's most consumed pharmacologically active food component. With reports of the potential cognitive enhancing properties of caffeine, we sought to investigate if caffeine can influence the anticholinesterase and antioxidant properties of donepezil-a selective acetylcholinesterase (AChE) inhibitor used in the management of Alzheimer's disease (AD). In vitro, we investigated the effect of donepezil (DON), caffeine (CAF) and their various combinations on the activity of AChE in rat brain homogenate, as well as determined their antioxidant properties...
January 13, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28091777/ultrasonography-for-endotracheal-tube-position-in-infants-and-children
#15
REVIEW
Pooja Jaeel, Mansi Sheth, Jimmy Nguyen
: Ultrasonography (US) has been shown to be effective for verifying endotracheal tube (ETT) position in adults but has been less studied in infants and children. We review the literature regarding US for ETT positioning in the pediatric population. A literature search was conducted using the Ovid and MEDLINE databases with search terms regarding US relating to ETT intubation and positioning in infants and children. Most studies in neonates and infants used the midsagittal suprasternal view...
January 13, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28091656/synthesis-and-characterisation-of-p-block-complexes-of-biquinoline-at-different-ligand-charge-states
#16
Juha Hurmalainen, Akseli Mansikkamäki, Ian S Morgan, Anssi Peuronen, Heikki M Tuononen
The first examples of p-block coordination complexes of biquinoline, namely [(biq)BCl2]Cl and [(biq)BCl2]˙, were synthesized and structurally characterized. The acquired data allowed the estimation of the ligand charge state based on its metrical parameters. The subsequent use of this protocol, augmented with theoretical calculations, revealed ambiguities in the published data for transition metal complexes of biquinoline.
January 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28091578/temporal-dynamics-of-cerebellar-and-motor-cortex-physiological-processes-during-motor-skill-learning
#17
D Spampinato, P Celnik
Learning motor tasks involves distinct physiological processes in the cerebellum (CB) and primary motor cortex (M1). Previous studies have shown that motor learning results in at least two important neurophysiological changes: modulation of cerebellar output mediated in-part by long-term depression of parallel fiber-Purkinje cell synapse and induction of long-term plasticity (LTP) in M1, leading to transient occlusion of additional LTP-like plasticity. However, little is known about the temporal dynamics of these two physiological mechanisms during motor skill learning...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28091404/left-atrial-mechanical-function-and-aortic-stiffness-in-middle-aged-patients-with-the-first-episode-of-atrial-fibrillation
#18
Alev Kilicgedik, Suleyman Ç Efe, Ahmet S Gürbüz, Emrah Acar, Mehmet F Yılmaz, Aslan Erdoğan, Gökhan Kahveci, Ibrahim A Izgi, Cevat Kirma
BACKGROUND: In the early stages of atrial remodeling, aortic stiffness might be an indication of an atrial myopathy, in particular, atrial fibrosis. This study aimed to investigate the association between left atrial (LA) mechanical function, assessed by two-dimensional speckle tracking echocardiography, and aortic stiffness in middle-aged patients with the first episode of nonvalvular atrial fibrillation (AF). METHODS: This prospective study included 34 consecutive patients with the first episode of AF, who were admitted to Kartal Koşuyolu Research and Training Hospital between May 2013 and October 2015, and 31 age- and gender-matched healthy controls...
2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28090510/augmented-and-virtual-reality-in-surgery-the-digital-surgical-environment-applications-limitations-and-legal-pitfalls
#19
REVIEW
Wee Sim Khor, Benjamin Baker, Kavit Amin, Adrian Chan, Ketan Patel, Jason Wong
The continuing enhancement of the surgical environment in the digital age has led to a number of innovations being highlighted as potential disruptive technologies in the surgical workplace. Augmented reality (AR) and virtual reality (VR) are rapidly becoming increasingly available, accessible and importantly affordable, hence their application into healthcare to enhance the medical use of data is certain. Whether it relates to anatomy, intraoperative surgery, or post-operative rehabilitation, applications are already being investigated for their role in the surgeons armamentarium...
December 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28090317/all-trans-retinoic-acid-enhances-cytotoxic-effect-of-t-cells-with-an-anti-cd38-chimeric-antigen-receptor-in-acute-myeloid-leukemia
#20
Tetsumi Yoshida, Keichiro Mihara, Yoshifumi Takei, Kazuyoshi Yanagihara, Takanori Kubo, Joyeeta Bhattacharyya, Chihaya Imai, Tatsuji Mino, Yoshihiro Takihara, Tatsuo Ichinohe
We reported that T cells with anti-CD38-chimeric antigen receptors (CAR) eliminated B-cell lymphoma cells expressing CD38. To employ anti-CD38-CAR against acute myeloid leukemia (AML) blasts not expressing CD38, it is necessary to induce or increase the intensity of CD38 expression. A lactate dehydrogenase (LDH)-releasing assay and flow cytometry showed that anti-CD38-CAR T cells were cytotoxic against AML lines (THP-1 and CMK) expressing high CD38 levels (>99%), in time- and number of effector-dependent manners...
December 2016: Clinical & Translational Immunology
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